ライフサイエンスコーパス: repair enzyme

1 d reaction mechanism for this intriguing DNA repair enzyme.

2 B points to its candidacy as a tRNA splicing/repair enzyme.

3 ls that PE exemplifies a unique class of DNA repair enzyme.

4 function as a general 3'-end-processing DNA repair enzyme.

5 functions as a uracil DNA glycosylase (UDG) repair enzyme.

6 bition of poly(ADP-ribose) polymerase, a DNA repair enzyme.

7 NA, implicating it as a flavin-dependent DNA repair enzyme.

8 p2 are more toxic than in cells lacking this repair enzyme.

9 erichia coli exonuclease III (ExoIII), a DNA repair enzyme.

10 e when the damaged base binds to its cognate repair enzyme.

11 ndonuclease 1 (Ape1), the major oxidized DNA repair enzyme.

12 e exonuclease into a recombination-promoting repair enzyme.

13 TOP1-mediated protein-linked DNA break (PDB) repair enzyme.

14 ed into DNA damage sites using type-specific repair enzymes.

15 at may serve as a recognition signal for DNA repair enzymes.

16 in the initial recognition of damaged DNA by repair enzymes.

17 to strains deficient in other base excision repair enzymes.

18 actor receptor (EGFR) overexpression and DNA repair enzymes.

19 vement of nucleotide excision repair or UVDE repair enzymes.

20 ble and not regulated by the availability of repair enzymes.

21 ATM activation and inhibiting DNA binding of repair enzymes.

22 base pairing and their interactions with DNA repair enzymes.

23 d association with DNA damage checkpoint and repair enzymes.

24 which may reduce DNA lesion accessibility to repair enzymes.

25 repair via interaction with a number of DNA repair enzymes.

26 repair of these adducts by the base excision repair enzymes.

27 ng after possible down-regulation of the DNA repair enzymes.

28 n and excision of damaged nucleobases by DNA repair enzymes.

29 ut the impact of higher order folding on DNA repair enzymes.

30 ich Chk2 protein regulates expression of DNA repair enzymes.

31 gh the relation between nitric oxide and DNA repair enzymes.

32 significant reduction in levels of excision repair enzymes.

33 ducts by DNA transcription, replication, and repair enzymes.

34 found to be a target of nucleotide excision repair enzymes.

35 a variety of proteins, including several DNA repair enzymes.

36 n-helix DNA-binding motif found in other DNA repair enzymes.

37 , and thereby prime it for processing by DNA repair enzymes.

38 g intermediates may be a common theme in DNA repair enzymes.

39 FTO), but only a subset functions as DNA/RNA repair enzymes.

40 esents one of the greatest challenges to DNA repair enzymes.

41 e tumor mutational burden and defects in DNA repair enzymes.

42 helicases, polymerases, recombinases and DNA repair enzymes.

43 m photolyases, bacterial light-activated DNA repair enzymes.

44 en members of this class of replication fork-repair enzymes.

45 mapping of modified nucleobases with cognate repair enzymes.

46 sting that they are removed by a "metabolite repair" enzyme.

47 demonstrate this method using the human DNA repair enzyme 3-methyladenine DNA glycosylase (AAG).

48 d identification of VPg unlinkase as the DNA repair enzyme, 5'-tyrosyl-DNA phosphodiesterase-2 (TDP2)

49 Furthermore, the base excision repair enzyme 7,8-dihydro-8-oxoguanine glycosylase (OGG1

50 markably dependent on a single base excision repair enzyme, 7,8-dihydro-8-oxoguanine-DNA glycosylase

51 (oxo8dG) levels and the activity of the DNA repair enzyme 8-oxoguanine DNA glycosylase (Ogg1) in rat

52 ast cancer by genetically modulating the DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1) in the

53 Using histone demethylase JMJD1A and DNA repair enzyme ABH2 as examples, we show that this family

54 ptamer selection to a medically relevant DNA repair enzyme, ABH2.

55 echanism to coordinate the activities of DNA repair enzymes across the genome.

56 pair pathways for more defined lesions, NHEJ repair enzymes act iteratively, act in any order, and ca

57 Direct measurement of DNA repair enzyme activities is important both for the basic

58 extended for analysis of a wide range of DNA repair enzyme activities.

59 adioactive and quantitative determination of repair enzyme activity at individual steps and over mult

60 sin protein nanopore was used to monitor DNA repair enzyme activity based on base-specific interactio

61 The Escherichia coli DNA repair enzyme AlkB is a 2-oxoglutarate (2OG)-dependent F

62 s express nine paralogs of the bacterial DNA repair enzyme AlkB, an iron/2-oxoglutarate-dependent dio

63 quantitative mechanistic scheme for the DNA repair enzyme AlkB.

64 d into a substrate (ZP1BG) for the human DNA repair enzyme alkylguaninetransferase (AGT or SNAP-Tag).

65 igated our hypothesis that the base excision repair enzyme alkylpurine-DNA-N-glycosylase (APNG), whic

66 The use of an inhibitor of a DNA repair enzyme alone to selectively kill a tumour, in the

67 rporation of HIF-1 and the bi-functional DNA repair enzyme and transcriptional coactivator, Ref-1/Ape

68 E3 to antagonize select postreplication DNA repair enzymes and activates the DNA damage checkpoint i

69 d light on the interplay between central DNA repair enzymes and an essential molecular chaperone.

70 Factor for DNA (DNA-SPF), using specific DNA repair enzymes and antibodies, and Sun Protection Factor

71 , alone and in complexes with a suite of DNA repair enzymes and antibodies, to directly quantify UVA

72 Because BLBC exhibits alterations in DNA repair enzymes and cell-cycle checkpoints, elucidation o

73 erized by mutations in numerous nucleic acid repair enzymes and elevated IFN levels.

74 insights into metal inhibition of other DNA repair enzymes and glycosylases.

75 le-strand break using purified base excision repair enzymes and human whole cell extracts.

76 The data suggests that IL-6 activates mtDNA repair enzymes and induces cell cycle arrest allowing ti

77 r repairing molecular damage by means of DNA-repair enzymes and protein-repair enzymes such as methyl

78 ent interactions of HIV-1 and HIV-2 with DNA repair enzymes and SAMHD1 imply that these viruses use d

79 e response involves the rapid recruitment of repair enzymes and the activation of signal transducers

80 ion endonucleases and many recombination and repair enzymes) and the HNH superfamily (found in an equ

81 proteins, by side reactions of base excision repair enzymes, and by cellular exposure to bifunctional

82 spanning DNA damage, molecular structures of repair enzymes, and clinical studies on inhibition of DN

83 vation-induced cytidine deaminase (AID), DNA repair enzymes, and post-class-switch expression of IgA

84 The follow-on base excision repair enzyme, AP endonuclease 1 (APE1), stimulates the

85 he abasic site in the recognition by the DNA repair enzyme Ape1 is discussed.

86 Besides its prominent role as a DNA repair enzyme, APE1 was separately identified as a prote

87 xpression of the essential base excision DNA repair enzyme apurinic endonuclease 1 (Ape1) in response

88 evated levels of the essential base-excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1

89 eraldehyde-3-phosphate dehydrogenase and DNA repair enzyme apurinic/apyrimidinic endonuclease I prote

90 owever, mice deficient for the base excision repair enzyme, apurinic/apyrimidinic endonuclease 2 (APE

91 dition to repairing mismatched DNA, mismatch repair enzymes are known in higher eukaryotes to directl

92 Two other DNA repair enzymes are known to repair epsilon-base lesions,

93 Host repair enzymes are predicted to complete this process.

94 Its effects on polymerases and repair enzymes are unknown.

95 ansposases, recombinases, integrases and DNA repair enzymes) are being harnessed or modified for the

96 The presence of a repair enzyme as a component of the viral replication ma

97 e demonstrate that, when bound to DNA, these repair enzymes become redox-active; binding to DNA shift

98 are (i) low false-positive rates because DNA repair enzyme binding is required for genome edits to oc

99 Biochemical analysis reveals a single repair enzyme-binding site on 9-1-1 that can be blocked

100 ridges between RNA polymerase, ribosome, and repair enzymes, blurring boundaries between separate inf

101 cancer 1 early onset gene codes for the DNA repair enzyme, breast cancer type 1 susceptibility prote

102 d in the co-evolution of DNMTs and ALKB2 DNA repair enzymes, but its mechanism remained elusive.

103 ange the levels or activity of base excision repair enzymes, but significantly reduced chromatin DNA

104 polymerases stalled at DNA lesions obstruct repair enzymes, but this situation is turned to the adva

105 lfur cluster in DinG and likely in other DNA repair enzymes by NO may contribute to NO-mediated genom

106 Our findings suggest that RNA repair enzymes can evolve their specificities to suit a

107 enotype, such that animals lacking all 3 DNA repair enzymes cannot survive even a single bout of chem

108 The activity of repair enzymes carries its own risk, however, because th

109 dividual archaeal PCNA subunits for selected repair enzyme 'clients', and provides insights into the

110 ded lesions affects their recognition by DNA repair enzymes, clustered damages are more difficult to

111 Surprisingly, deficiency in all 3 DNA repair enzymes confers a massively synergistic phenotype

112 An array of DNA-repair enzymes constitutes an essential part of the line

113 Endonuclease III (EndoIII), a base excision repair enzyme, cooperate at long-range using DNA charge

114 Cleavage assays with lesion-specific DNA repair enzymes coupled to ligation-mediated PCR showed p

115 otein TP53I3, transcription factor ATF3, DNA repair enzyme DDB2, and the beta-adrenergic receptor ADB

116 The DNA base excision repair enzyme DNA polymerase (pol) beta is presented wit

117 structures of the R283K mutant of human DNA repair enzyme DNA polymerase beta (pol beta) differing i

118 crystal structure of the human base excision repair enzyme DNA polymerase beta (Pol beta) in complex

119 We identified two promising genes in the DNA repair enzyme DNA polymerase beta and in the neuroendocr

120 ated for inhibitory activity against the DNA repair enzyme DNA-dependent protein kinase (DNA-PK), wit

121 The DNA repair enzyme, DNA polymerase beta (Pol beta), is among

122 erozygous for the critical DNA base excision repair enzyme, DNA polymerase beta.

123 cells show elevated activation of a key DSB repair enzyme, DNA-dependent protein kinase catalytic su

124 Fe-S incorporation into MMS19-dependent DNA repair enzymes, DNA repair capacity, sensitivity to DNA-

125 ation plays an important role in controlling repair enzymes during the DNA damage response (DDR).

126 tional formamidopyrimidine glycosylase (Fpg) repair enzyme (E) that recognizes an 8-oxodG lesion with

127 leases (e.g., T7 gene 6 exonuclease) and DNA repair enzymes (e.g., uracil-DNA glycosylase).

128 ted and probed with the Escherichia coli DNA repair enzyme endonuclease IV (endo IV), which recognize

129 intramolecular electron transfer in the DNA-repair enzyme, Escherichia coli photolyase, a protein cl

130 nding protein-interacting protein (CtIP) DNA repair enzyme, establishing a role for CtIP in regulatin

131 Our understanding of how repair enzymes excise modified bases without acting on u

132 a coli RecQ, a central DNA recombination and repair enzyme, exhibits differential processing of DNA s

133 n replication and for the essential role of "repair" enzyme ExoIII in demethylation leading to the re

134 h as temozolomide lose their efficacy if DNA repair enzyme expression is upregulated.

135 DNA replication and repair enzyme Flap Endonuclease 1 (FEN1) is vital for ge

136 isoaspartate O-methyltransferase activity, a repair enzyme for isoAsp residues in vivo, remains stabl

137 yrosyl-DNA phosphodiesterase 1 (TDP1), a key repair enzyme for trapped Top1cc, hydrolyzes the phospho

138 elong to a family of flavoproteins acting as repair enzymes for UV-B-induced DNA lesions (photolyases

139 DNA mismatch repair enzymes (for example, MSH2) maintain genomic inte

140 and its normal counterpart, guanine, by the repair enzyme, formamidopyrimidine-DNA glycosylase (Fpg)

141 f DNA with histones in chromatin impedes DNA repair enzymes from accessing DNA lesions.

142 ine DNA Glycosylase (TDG) is a base excision repair enzyme functioning in DNA repair and epigenetic r

143 ated demethylation promoted by Base Excision Repair enzymes further modifies methylation of the repai

144 ed by high rates of occurrence or defects in repair enzymes, has been implicated in multiple diseases

145 Several human DNA replication and repair enzymes have recently been shown to be acetylated

146 Targeting the DNA repair enzyme human 8-oxoguanine DNA glycosylase (hOGG1)

147 ssion vector containing the gene for the DNA repair enzyme human 8-oxoguanine DNA glycosylase/apurini

148 The DNA repair enzyme human uracil DNA glycosylase (UNG) scans s

149 therapeutics as inhibitors of a critical DNA repair enzyme, human AP endonuclease.

150 rase lambda (pol lambda), a low-fidelity DNA repair enzyme in the X-family that fills short nucleotid

151 The presence of multiple versions of DNA repair enzymes in a single organism is usually thought t

152 importance of RecA and DNA recombination and repair enzymes in conferring resistance to H(2)O(2) dama

153 looping in CSR, and the roles of certain DNA-repair enzymes in CSR.

154 f alpha-KG/Fe(II)-dependent proteins-the DNA repair enzymes in the AlkB family, which include ALKBH2,

155 track that allows long-range sliding of DNA repair enzymes in their search for rare damage sites in

156 Analysis of the involvement of DNA repair enzymes in trimethoprim-induced cytotoxicity clea

157 n of DNA repair pathways and the function of repair enzymes in vivo have remained unclear because of

158 yrosyl-DNA-phosphodiesterase 1 (TDP1), a DNA repair enzyme, in ATL cells.

159 adaptive processing of the DNA damage by DNA repair enzymes, in particular by MutM and MutY DNA glyco

160 ons are further processed by downstream DNA "repair" enzymes including error-prone translesion polyme

161 Because many DNA methyltransferases and DNA repair enzymes induce similar DNA distortions, these res

162 Therefore, targeting DNA repair enzymes into beta-cell mitochondria could be a po

163 purinic/apyrimidinic endonuclease 1 is a DNA repair enzyme involved in genome stability and expressio

164 ve characterized meningococcal base excision repair enzymes involved in the recognition and removal o

165 DNA 'sliding' by human repair enzymes is considered to be important for DNA dam

166 The promiscuity of DNA repair enzymes is particularly important, because it ena

167 A hallmark of these and other DNA repair enzymes is their use of base flipping to sequeste

168 oly(ADP-ribose) polymerase-1 (PARP-1), a DNA repair enzyme, is involved in the induction of necrosis

169 stream activities of the major base excision repair enzymes, it may act as a regulator for the base e

170 phoesterase (PE) domain of the bacterial DNA repair enzyme LigD possesses distinctive manganese-depen

171 Thus, induction of DNA repair enzymes may be a unique strategy for neuroprotect

172 their processing by cellular replication and repair enzymes may be differentially affected by their a

173 illing by HOCl, whereas over-expression of a repair enzyme, methionine sulfoxide reductase A, rendere

174 Mutant forms of the DNA repair-enzyme methylguanine methyltransferase in particu

175 The mismatch repair enzymes MSH2, MSH3, and MSH6, implicated in repea

176 structurally elucidated a base-excision DNA repair enzyme, MutM, at the stage of initial encounter w

177 t overexpression of catalase or DNA mismatch repair enzyme, MutS, and antioxidant pretreatment limit

178 oxidative DNA damage, expression of the DNA repair enzyme MutS2, and mutations in cagY, demonstratin

179 rol of the N-glycosylase reaction by the DNA repair enzyme, MutY, entails the organization of solvent

180 ds to oxidation of a DNA-bound base excision repair enzyme, MutY.

181 Higher expression of the human DNA repair enzyme MUTYH has previously been shown to be stro

182 chondrial topoisomerase TOP1MT, the mismatch repair enzyme MUTYH, and the apurinic-apyrimidinic endon

183 ation in the gene encoding the base excision repair enzyme Nei endonuclease VIII-like 3 (NEIL3) that

184 Editing of the pre-mRNA for the DNA repair enzyme NEIL1 causes a lysine to arginine change i

185 The DNA repair enzyme NEIL1 is a DNA glycosylase that is involve

186 d using a lentiviral vector encoding the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AG

187 Expression of the DNA repair enzyme O(6)-methylguanine-DNA methyltransferase (

188 olomide; however, gliomas expressing the DNA repair enzyme O(6)-methylguanine-DNA methyltransferase (

189 ce gene, such as the P140K mutant of the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MG

190 The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MG

191 oduct 8-oxoG and increased levels of the DNA repair enzyme OGG-1.

192 the injury by increased production of mtDNA repair enzymes (OGG-1, Neil 1) and check point (p21, p53

193 r studying the activity of Klenow exo(-) and repair enzymes on templates containing the lesion.

194 es over DNA, the ionic dependence of the DNA repair enzyme PARP1 in DNA binding, and the interaction

195 inflammation, cellular infiltration, tissue repair enzymes, pathways of oxidative stress, and altere

196 The DNA repair enzyme photolyase provides a natural system that

197 quence identity with the light-activated DNA repair enzyme photolyase.

198 The same is also true for the DNA repair enzyme, photolyase.

199 ial cells, which, in turn, activates the DNA repair enzyme poly(ADP)-ribose polymerase.

200 labelled small-molecule inhibitor of the DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP1) for

201 Inhibition of the DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP1) with

202 ivation of caspase-3 and the cleavage of DNA repair enzyme poly(ADP-ribose) polymerase were inhibited

203 Inhibition of the DNA repair enzyme poly(ADP-ribose) polymerase-1 (PARP-1) has

204 dels, possibly through inhibition of the DNA repair enzyme poly-ADP-ribose polymerase and prevention

205 tol also resulted in cleavage of the nuclear repair enzyme, poly(ADP-ribose) polymerase (PARP) and in

206 nexin V binding, the inactivation of the DNA repair enzyme, poly(ADP-ribose) polymerase, and the acti

207 This may be due to the activation of the DNA repair enzyme, poly(ADP-ribose) polymerase, in response

208 itinating activity regulate the cellular DNA repair enzyme polymerase eta and recruit it to potential

209 ase II subunit A (POLR2A), ataxin-3, the DNA repair enzyme polynucleotide-kinase-3'-phosphatase (PNKP

210 The dual function mammalian DNA repair enzyme, polynucleotide kinase (PNK), facilitates

211 se (AID) and is completed by error-prone DNA repair enzyme processing of AID-generated uracils.

212 Plant andphage tRNA repair enzymes protect yeast from gamma-toxin because th

213 t that Cry1 and Cry2, which evolved from DNA repair enzymes, protect genomic integrity via coordinate

214 f isoAsp in cells is limited by a ubiquitous repair enzyme, protein l-isoaspartyl methyltransferase (

215 two nonmembrane-bound ABC proteins, the DNA repair enzyme Rad50 and a structural maintenance of chro

216 marker of double-strand breaks) and the DNA-repair enzyme RAD51.

217 ed by the impaired recruitment of a core DNA repair enzyme, RAD51, to replication-induced DNA damage

218 strikingly reminiscent of one subset of DNA-repair enzymes, raising important mechanistic and drug-d

219 pacts are discussed in terms of differential repair enzyme recognition, processing and translesion sy

220 DNA repair enzymes recognize and remove damaged bases that a

221 The process by which DNA repair enzymes recognize and selectively excise damaged

222 The co-transcription factor and DNA repair enzyme, Redox effector factor-1/apurinic/apyrimid

223 g DNA-mediated electron transfer among these repair enzymes; redox activation upon DNA binding and ch

224 ion and the role of host double-strand break repair enzymes remain unknown.

225 studies Tomas Lindahl has shown how specific repair enzymes remove and replace damaged parts of DNA i

226 helicase is one of several recombination or repair enzymes required for efficient levels of pilin Av

227 tion enzymes, restriction endonucleases, DNA-repair enzymes, resolvases, intron splicing factors and

228 sferase, thioredoxin, glutaredoxins, and DNA repair enzymes responded most strongly to cadmium and ch

229 uanine glycosylase (OGG1) is a base excision repair enzyme responsible for the recognition and remova

230 ally and biomedically important group of DNA repair enzymes responsible for initiating base excision

231 -methylcytosine, and follow-on base excision repair enzymes restore a G.C pair.

232 ng-standing questions about the way in which repair enzymes search for DNA lesions and form protein c

233 r109c and human FGGY could act as metabolite repair enzymes, serving to re-phosphorylate free d-ribul

234 covalent DNA-protein cross-links (DPCs) with repair enzymes such as DNA polymerase beta (polbeta).

235 DNA repair enzymes such as human uracil-DNA glycosylase (hUN

236 e by means of DNA-repair enzymes and protein-repair enzymes such as methyltransferase is found to be

237 -oxidized abasic site with Klenow exo(-) and repair enzymes suggest that the lesion will be mutagenic

238 eveals a previously unsuspected role for the repair enzyme TDG as a repressor of smooth muscle differ

239 hylated cytosines requires the base excision repair enzyme TDG, but the mechanism by which TDG-depend

240 nteracts with and requires the base excision repair enzymes TDG and APE1 for active demethylation.

241 The DNA repair enzyme telomerase maintains chromosome stability

242 vealed that AlkB is a much faster alkylation repair enzyme than previously reported and that it is si

243 cosylase) is one such silenced base excision repair enzyme that can restore DNA integrity.

244 nd a DNA 3' phosphate and functions as a DNA repair enzyme that cleaves stalled topoisomerase I-DNA c

245 The NEIL3 DNA glycosylase is a base excision repair enzyme that excises bulky base lesions from DNA.

246 acil DNA glycosylase (UNG) is a powerful DNA repair enzyme that has been shown to stabilize a glycosy

247 cil DNA glycosylase (UNG2) is a cellular DNA repair enzyme that is essential for a number of diverse

248 oss-complementation group 1 (ERCC1) is a DNA repair enzyme that is frequently defective in non-small

249 lease 1 (APE1) is an essential base excision repair enzyme that is upregulated in a number of cancers

250 ive site complex with DNA polymerase beta, a repair enzyme that plays an important role in base excis

251 uanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that protects cells from carcinogenic effe

252 il DNA glycosylase (UNG) is an important DNA repair enzyme that recognizes and excises uracil bases i

253 recognition by Escherichia coli AlkB, a DNA repair enzyme that removes methyl adducts and some large

254 yrosyl-DNA phosphodiesterase (TDP1) is a DNA repair enzyme that removes peptide fragments linked thro

255 alkyltransferase (AGT) is a single-cycle DNA repair enzyme that removes pro-mutagenic O(6)-alkylguani

256 Ribonuclease H2 (RNase H2) is a nucleic acid repair enzyme that removes unwanted ribonucleotides from

257 e kinetic and thermodynamic parameters for a repair enzyme that targets nucleic acid substrates conta

258 Contrary to many DNA repair enzymes that can directly reject non-target sites

259 Archeoglobus fulgidus, are all base excision repair enzymes that contain the [4Fe-4S](2+) cofactor.

260 onserved substrate recognition domain in DNA repair enzymes that couples ATP-hydrolysis to remodeling

261 The Rh-PPO mechanism is reminiscent of DNA repair enzymes that displace mismatched bases, and is di

262 for the ubiquitous [4Fe-4S] clusters in DNA repair enzymes that involves redox chemistry and provide

263 ise a ubiquitous superfamily of nucleic acid repair enzymes that join 3'-OH and 5'-PO4 DNA or RNA end

264 minated purine nucleobases are essential DNA repair enzymes that protect the genome, and at the same

265 t recognize nucleobases, including other DNA repair enzymes that recognize other types of extrahelica

266 is a class of ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobase

267 ate that the method, in conjunction with DNA repair enzymes that remove damaged bases to produce alde

268 by DNA polymerases work in parallel with DNA repair enzymes that remove lesions produced by modified

269 NA editing ligases exemplify a family of RNA repair enzymes that seal 3'OH/5'PO(4) nicks in duplex RN

270 .TTC repeat during transcription attract DNA repair enzymes that then facilitate the expansion proces

271 ssed by uracil base excision and/or mismatch repair enzymes that ultimately generate switch region DN

272 ERASE (PIMT) is a widely distributed protein-repairing enzyme that catalyzes the conversion of abnorm

273 required for stabilization of base excision repair enzymes, the failure of cells to downregulate Mul

274 apparent lack of the normal set of mismatch repair enzymes, the results from this study may suggest

275 and its derivatives in DNA are bound by DNA repair enzymes through hydrogen bonding and pi-pi stacki

276 FAN1 encodes a DNA repair enzyme, thus implicating abnormalities in DNA rep

277 Human (h) DNA repair enzyme thymine DNA glycosylase (hTDG) is a key DN

278 have shown previously that the base excision repair enzyme thymine DNA glycosylase (TDG) acts as a po

279 We reasoned that the base excision repair enzyme thymine DNA glycosylase (TDG) could be suc

280 nockout or catalytic inactivation of the DNA repair enzyme thymine DNA glycosylase (TDG) leads to emb

281 hOGG1-Tat fusion protein to target the hOGG1 repair enzyme to mitochondria and enhance mtDNA repair.

282 trategies for modulating the levels of mtDNA repair enzymes to delay or stall metastatic progression.

283 ktracking and recruiting nucleotide excision repair enzymes to exposed lesions.

284 RNA polymerase, allowing nucleotide excision repair enzymes to gain access to sites of damage.

285 containing the lesion to a form that allows repair enzymes to remove the blocking lesion and DNA syn

286 1 from a family of ancestral promiscuous RNA repair enzymes to the highly selective enzymes needed fo

287 tin requires mechanisms that allow access of repair enzymes to the lesions.

288 A classic example is the DNA repair enzyme uracil DNA glycosylase (UDG) which recogni

289 reported Vpr interactions with base excision repair enzyme uracil DNA glycosylase (UNG2) and crossove

290 oretical study showed that the base excision repair enzyme uracil-DNA glycosylase (UDG) exploits elec

291 in are for T4 polynucleotide kinase, the DNA repair enzymes uracil-DNA glycosylase (UDG) and formamid

292 21 years ago, the DNA Repair Enzyme was declared "Molecule of the Year".

293 of the two mammalian uracil-DNA glycosylase repair enzymes, we were able to test this model of FU cy

294 ay is sensitive enough to detect kinetics of repair enzymes when confronted with DNA mismatches or DN

295 unique pathway by focusing on the human APE1 repair enzyme, which catalyzes the incision of phosphodi

296 s, mitochondrial proteins, histones, and DNA repair enzymes, which have not been associated with diff

297 ents is limited because of the action of DNA repair enzymes, which mitigate the damage induced by the

298 Thus, RtcB is a bona fide RNA repair enzyme with broad physiological actions.

299 el to show that there is an optimum level of repair enzymes within cells which optimises the cell's r

300 an increased nuclear localization of the DNA repair enzyme XPA.