ライフサイエンスコーパス: repair mechanism

1 EJ) is a major DNA double-strand break (DSB) repair mechanism.

2 es are side-byproducts unassociated with the repair mechanism.

3 es place by a highly efficient base excision repair mechanism.

4 ronment subsequent to compromised injury and repair mechanism.

5 entially connected to a replicative mismatch repair mechanism.

6 ium sensor involved in the lysosome-mediated repair mechanism.

7 mutations is not because of defects in this repair mechanism.

8 rivative, was also employed to probe the ICL repair mechanism.

9 through an EGCG-induced IL-12-dependent DNA repair mechanism.

10 arcinogenesis through an IL-12-dependent DNA repair mechanism.

11 observed role of Ca(2+) is to engage a wound repair mechanism.

12 hese interactions contribute to the mismatch repair mechanism.

13 lap endonuclease processing via a long patch repair mechanism.

14 n-tunneling pathway that is critical for the repair mechanism.

15 cular control, including integrity check and repair mechanisms.

16 crucial to understand how to improve natural repair mechanisms.

17 he expression of genes that act in different repair mechanisms.

18 elivery and the overlap of cancer and neural repair mechanisms.

19 what extent their formation depends upon DSB repair mechanisms.

20 scular disease and dysfunctional endothelial repair mechanisms.

21 modulation of cellular stress responses and repair mechanisms.

22 oliferation in an attempt to initiate innate repair mechanisms.

23 ptations of membranes, proton pumps, and DNA repair mechanisms.

24 ly-ADP ribose polymerase (PARP)-mediated DNA repair mechanisms.

25 ic, as has its relationship to canonical DNA repair mechanisms.

26 ic sex development from existing prokaryotic repair mechanisms.

27 on, damage that is not amenable to the usual repair mechanisms.

28 ion following acute lung injury to elucidate repair mechanisms.

29 ng in fixed mutations via host-dependent DNA repair mechanisms.

30 suppression of inflammation and promotion of repair mechanisms.

31 m the DNA lesion and activates intrinsic DNA repair mechanisms.

32 st likely reflecting the role of PNKP in DNA-repair mechanisms.

33 ocus in the genome and invoke endogenous DNA repair mechanisms.

34 eted as a therapeutic approach for enhancing repair mechanisms.

35 anslates into an impairment of PSC-dependent repair mechanisms.

36 tresses, bacteria induce both resistance and repair mechanisms.

37 could be involved in the MRL/MpJ spinal cord repair mechanisms.

38 ould be core components of the mitochondrial repair mechanisms.

39 el, mainly through stimulation of endogenous repair mechanisms.

40 T(H)17, and IL36 responses and skin barrier repair mechanisms.

41 n) are often considered to reflect different repair mechanisms.

42 s, which in turn signal downstream epidermal repair mechanisms.

43 ry responses, while sparing host defense and repair mechanisms.

44 mary cultures, including cells with impaired repair mechanisms.

45 nsitivity to promotional stimuli, like wound repair mechanisms.

46 posed roles in DNA pairing and recombination/repair mechanisms.

47 nds designed to enhance barrier function and repair mechanisms.

48 DNA, which are then substrates for cellular repair mechanisms.

49 potential roles in telomere biology and DNA repair mechanisms.

50 ultiple independent DNA damage avoidance and repair mechanisms.

51 d joining that can provide insights into DNA repair mechanisms.

52 rs by targeting alpha-synuclein-mediated DNA repair mechanisms.

53 Surviving infection requires immune and repair mechanisms.

54 chemokine receptor CXCR4 promote epithelial repair mechanisms.

55 by driving initial symptoms, but by altering repair mechanisms.

56 that are crucial in coordinating DNA damage repair mechanisms.

57 gions of chromatin that are deficient in DNA repair mechanisms.

58 onal function, cilia, epithelial growth, and repair mechanisms.

59 reatment and are central regulators of renal repair mechanisms.

60 ole-genome sequencing analysis to define DNA repair mechanisms.

61 matory signals and enhance endogenous tissue repair mechanisms.

62 of innate immunity, and promotion of tissue repairing mechanisms.

63 The repair mechanisms acting on DNA interstrand crosslinks (

64 t transplanted stem cells enhance endogenous repair mechanisms activated after cerebral ischaemia.

65 ing properties of NK314, to evaluate the DNA repair mechanisms activated in cells that may lead to re

66 further, indicating that HR is the major DNA repair mechanism after G2/M phase arrest.

67 se to physiological stress and an endogenous repair mechanism after ischemic injury.

68 could bridge a major gap in knowledge of the repair mechanism after myocardial injury.

69 Mismatch correction occurs by an excision-repair mechanism and has been shown to depend on the 5'

70 our findings lend insights into a basic DNA repair mechanism and how the precise location of a DSB m

71 helicase gene resulted in defects in the DNA repair mechanism and was reported to be associated with

72 modeling, as they enhance endogenous cardiac repair mechanisms and decrease cardiomyocyte apoptosis.

73 mediated by polymorphisms in genes governing repair mechanisms and inflammation in the peripheral ner

74 suggesting a trade-off between highly active repair mechanisms and late-life pathology in females.

75 ely relies on the mobilization of endogenous repair mechanisms and local factors that control them.

76 one of the most frequently used cellular DNA repair mechanisms and modulates many human pathophysiolo

77 In this review, we discuss DNA repair mechanisms and strategies used to target them in

78 lities such as dependencies on 'superfluous' repair mechanisms and the induction of tumor-specific an

79 vitamin D can positively modify endothelial repair mechanisms and thus endothelial function in a pop

80 tions in this process, the co-option of DNA 'repair' mechanisms and AID evolution.

81 esource useful for studying DNA breakage and repair mechanisms, and for analyzing the genetic basis o

82 l of the cell cycle, response to stress, DNA repair mechanisms, and more.

83 refractory alveolar damage, ineffective lung repair mechanisms, and systemic inflammation with associ

84 metabolic state of the cells as well as DNA repair mechanisms, and that small changes in these condi

85 tical cell cycle events are halted while DNA repair mechanisms are activated to restore genome integr

86 normal in patients with SLE, and endothelial repair mechanisms are also impaired.

87 We hypothesize that recombination-based DNA-repair mechanisms are at least partially responsible for

88 ective neuroprotection and enhance intrinsic repair mechanisms are central goals for future therapy o

89 rates in vivo or in cell lines where all DNA repair mechanisms are functional.

90 DNA repair mechanisms are fundamental for B cell development

91 DNA repair mechanisms are less able to repair DSBs compared

92 Because endogenous cardiac repair mechanisms are not sufficient for meaningful tiss

93 ing this procatabolic stimulus such that the repair mechanisms are ultimately overwhelmed by degradat

94 of stem cells and their progeny, though the repair mechanisms are unclear.

95 se activity in synthesis associated with DNA repair mechanisms as the cause of local increase in poin

96 ur results will inform investigations of DSB repair mechanisms as well as the design of CRISPR/Cas9 e

97 snake toxins to cope with different membrane repair mechanisms at the cellular levels.

98 , stress/senescence marker proteins, and DNA repair mechanisms at the gene expression level.

99 hich take advantage of homology-directed DNA repair mechanisms at the site of nuclease action.

100 Damage repair mechanisms at transcriptionally active sites duri

101 It is well established that cardiovascular repair mechanisms become progressively impaired with age

102 ssODN, demonstrating the specificity of the repair mechanism being recruited.

103 overexpression of caveolin-1 inhibits muscle repair mechanisms both in vitro and in vivo.

104 Ruxolitinib inhibited 2 major DSB repair mechanisms, BRCA-mediated homologous recombinatio

105 HR is the most accurate DSB repair mechanism but is generally restricted to the S an

106 important discoveries about DNA breakage and repair mechanisms, but also offer important clues about

107 e hypothesize this endogenous liver fibrosis repair mechanism can be leveraged for liver metastasis t

108 nism was used so that the cell's "choice" of repair mechanism can have profound genetic consequences.

109 hila, to show that the relative usage of DSB repair mechanisms can change substantially as an organis

110 singly, inherited or sporadic defects in DNA repair mechanisms can give rise to cellular outcomes tha

111 nd react to DNA damage; the induction of DNA repair mechanisms can lead to genomic restoration or, if

112 ts a relatively rare but very unfaithful DSB repair mechanism causing chromosomal aberrations.

113 show that MYCC (c-Myc) expression alters DNA repair mechanisms, cell cycle checkpoints, and karyotypi

114 likely participates in a viral base excision repair mechanism, characterized by low fidelity.

115 gh the LINC complex may serve as an input to repair mechanism choice and efficiency.

116 xin sensitivity, indicating that back-up DSB repair mechanisms compensate for Rad18 deficiency.

117 As such, cells have a robust wound repair mechanism comprised of dynamic membrane resealing

118 Whether additional general DNA repair mechanisms contribute to ribonucleotide removal f

119 ls (BMCs) are critically involved in cardiac repair mechanisms contributing to preserved cardiac func

120 Many DNA repair mechanisms cooperate in cells to fight DNA damage

121 ytochalasin D, which inhibits membrane actin repair mechanisms, crocidolite or applied Fe(3+)/H(2)O(2

122 umulate mutations and lacks conventional DNA repair mechanisms, deleterious mutations are exceedingly

123 DNA double-strand break (DSB) repair mechanisms differ in their requirements for a hom

124 regeneration for injuries for which natural repair mechanisms do not deliver functional recovery and

125 Such DNA repair mechanisms either stall the cell cycle to allow r

126 We propose that elucidation of DNA repair mechanisms elicited by different irradiation dosi

127 y, and the robust and flexible nature of DNA repair mechanisms elicited by telomere dysfunction.

128 Restoration of DNA repair mechanisms emerges as an important therapeutic ta

129 ost physiologically predominant forms of DNA repair mechanisms, emerging lines of evidence suggest th

130 A (mtDNA) is prone to mutation and few mtDNA repair mechanisms exist, crippling mitochondrial mutatio

131 multiple steps of the essential S-phase ICL repair mechanism fail when the Fanconi anemia pathway is

132 effects can also result from activating DNA repair mechanisms following damage.

133 by perturbing cell cycle progression and DNA repair mechanisms following DNA damage, we examined the

134 provides a model for a replication-dependent repair mechanism for double-strand breaks (DSBs) at rear

135 interpret this increase with repetition as a repair mechanism for strengthening the internal represen

136 port suggests a role for a non-base excision repair mechanism for the removal of 8-oxo-7,8-dihydrogua

137 tegies that might improve the body's natural repair mechanisms for treating patients with wound-closu

138 merous complex and redundant replication and repair mechanisms function in tandem with the core repli

139 Deficiency in DNA double-strand break (DSB) repair mechanisms has been widely exploited for the trea

140 unprecedented quantitative insight into DNA repair mechanisms has come from the new-found ability to

141 esion synthesis (TLS, a post-replication DNA repair mechanism) has been suggested, but the basis for

142 Two scenarios for the repair mechanism have been suggested that differ in the

143 DNA damage repair mechanisms have been most thoroughly explored in

144 Approaches that enable innate repair mechanisms hold great potential for tissue repair

145 One such DNA repair mechanism, homologous recombination, has the capa

146 promotes unfaithful recombination-dependent repair mechanisms HRR and SSA, and enhances the loss of

147 Nucleotide excision repair is a major DNA repair mechanism in all cellular organisms.

148 membrane lesions, which could be part of the repair mechanism in hair cells after noise damage.

149 The most common DSB repair mechanism in human cells, non-homologous end join

150 ghlight the significance of the abnormal DNA repair mechanism in male infertility.

151 provide evidence for a homology-directed DNA repair mechanism in mitochondria that is directly linked

152 ascularization is an important physiological repair mechanism in response to ischemic injury, and its

153 -NHEJ) was originally identified as a backup repair mechanism in the absence of classical NHEJ (c-NHE

154 Our results show a self-repair mechanism in the mammalian brain and may have imp

155 transposition, and may hint at a common gap-repair mechanism in these diverse transposons.

156 ICLs in various DNA structures via a genuine repair mechanism in which complex DNA lesions can be rem

157 A interstrand crosslinks and determine their repair mechanism in Xenopus egg extracts.

158 existence of endogenous cardiac renewal and repair mechanisms in adult mammalian hearts that could c

159 integrity of DSB recognition, signaling, and repair mechanisms in B lymphoblastoid cell lines derived

160 are not subject to p53-mediated DNA excision repair mechanisms in B-CLL cells.

161 initial airway inflammatory, remodeling, and repair mechanisms in CF lung disease.

162 Due to the loss of DNA repair mechanisms in colorectal cancer (CRC) with micros

163 pproaches to restore the impaired epithelial repair mechanisms in COPD, which is still a high medical

164 Its interaction with DNA activates damage repair mechanisms in cultured cells and causes DNA stran

165 des a foundation for further explorations of repair mechanisms in different chromatin domains.

166 metabolite damages not only DNA but also DNA repair mechanisms in human cells.

167 pplications and facilitates the study of DNA repair mechanisms in mammalian cells.

168 Although DSB repair in nDNA is well studied, repair mechanisms in mitochondria are not characterized.

169 The reasons for the eventual failure of repair mechanisms in multiple sclerosis are unknown.

170 ions on nanoparticle-mediated DNA damage and repair mechanisms in plants.

171 ys in which the cell differentially utilizes repair mechanisms in response to both changes in the gen

172 G) to establish a model for investigation of repair mechanisms in salivary glands (SGs).

173 , E or E+P increased gene expression for DNA repair mechanisms in serotonin neurons, thereby renderin

174 e dysregulation of endogenous cardiovascular repair mechanisms in the aging heart and vasculature.

175 y may have important implications for injury/repair mechanisms in the CF airway.

176 enzymes that are involved in both injury and repair mechanisms in the CNS.

177 mplicates both major DNA double-strand break repair mechanisms in the generation of 8p alterations.

178 We explored DSB repair mechanisms in the yeast Saccharomyces cerevisiae

179 s of this review is on the comparison of DNA repair mechanisms in young versus old.

180 ovide the first example of an intramolecular repairing mechanism in synthetic molecules in solution,

181 models for the mammalian NER-independent ICL repair mechanism, in which a DNA endonuclease(s) unhooks

182 Repair mechanisms include the participation of endogenou

183 It coincides with activation of repair mechanisms, including accumulation of extracellul

184 t during HR with the unique aspects of these repair mechanisms, including mutagenesis and template sw

185 are essential for structural and functional repair mechanisms, including regeneration of cerebral wh

186 ic and found that the oxidative stress-break repair mechanism increased the emergence of antibiotic-r

187 Among double-strand break repair mechanisms induced by oncogenic stress, the highl

188 The complexity of DNA repair mechanisms infers that xenobiotics, derived from

189 onuclease, followed by mending of the DNA by repair mechanisms inherent in cells.

190 type of ssODN used and by modulation of the repair mechanism involved in the correction process.

191 nd theory it is demonstrated that the acting repair mechanism involves proton transfer from the proto

192 ICLs, possibly in a transcription-associated repair mechanism involving SNM1A, and that defects in th

193 however, the recent discovery of endogenous repair mechanisms involving hematopoietic stem and other

194 Our study shows that the choice of repair mechanism is continuously adjusted throughout the

195 lls, indicating that the nucleotide excision repair mechanism is involved in EGCG-mediated DNA repair

196 The damage repair mechanism is modeled by an expanded reaction-rate

197 Our ribose-protonated repair mechanism is not only energetically more preferab

198 Redundancy of TOP1-mediated repair mechanisms is a major challenge facing the effici

199 described here is that the character of the repair-mechanisms is reflected by the secondarily built

200 ecombination (HR), although an important DNA repair mechanism, is dangerous to the cell if improperly

201 a DSB; and as a functional component of DNA repair mechanism itself.

202 itches based on CRISPR/Cas9 (Ca) and the DNA repair mechanism known as single-strand annealing (SSA).

203 Dysregulated or insufficient organ repair mechanisms limit restoration of homeostasis and c

204 the rate of replication and functionality of repair mechanisms; little is known, however, about the c

205 turn, DNA damage activates a variety of DNA repair mechanisms, many of which are activated in vascul

206 Elucidation of the PSII repair mechanism may reveal the occurrence of hitherto u

207 n, the exploitation of endogenous brain self-repair mechanisms may also yield therapeutic strategies.

208 We show that although end-joining repair mechanisms may cause the system to break down, un

209 modulating sprouting, a naturally occurring repair mechanism, may be a more attainable therapeutic g

210 A differential DNA repair mechanism might protect certain non-Ig loci such

211 Given the central role of translation, such repair mechanisms might be widespread in nature.

212 Failure of dermal protection or repair mechanisms might lead to visibly aged skin.

213 Recently, a third, less characterized repair mechanism, named microhomology-mediated end joini

214 tions between inflammation signaling and DNA repair mechanisms now elucidate how epigenetic therapy e

215 us DNA end joining (NHEJ) is the predominant repair mechanism of any type of DNA double-strand break

216 the inverse dependence of anions in the self-repair mechanism of Co-OECs.

217 ons and deletions consistent with a hAT-type repair mechanism of hairpin formation and non-homologous

218 not, thanks to the presence of an efficient repair mechanism of PSII.

219 ifferent efficiencies of photoprotection and repair mechanisms of algal food sources play a role in t

220 ng an essential role in oxidative DNA damage repair mechanisms of GAS, dual functions predicted to co

221 crucial in order to understand the intrinsic repair mechanisms of the brain, and key to designing the

222 These mutations arise by different repair mechanisms of the double-strand break produced by

223 to understand aspects of the robust pattern repair mechanisms of the Drosophila embryonic epidermal

224 ntegrity, organisms have evolved several DSB repair mechanisms, of which nonhomologous end-joining (N

225 h the activation of pathways responsible for repair mechanisms, often resulting in a delay/arrest in

226 All known abasic site repair mechanisms operate only when the damage is in dou

227 dystrophy type 1, and suggests a common DNA repair mechanism operates in both repeat expansion disea

228 ormation may reflect an endogeneous neuronal repair mechanism, or it could be a by-product of radiati

229 s recognized by sensor proteins that trigger repair mechanisms, or, if repair is unsuccessful, initia

230 lular damage is beyond the capability of the repair mechanisms, p53 induces apoptosis or cell cycle a

231 It can be expected that DNA repair mechanisms play important roles in cpDNA survival

232 de excision repair is a highly conserved DNA repair mechanism present in all kingdoms of life.

233 high mutation rate of the mtDNA and limited repair mechanisms present in the mitochondrion.

234 In summary, HO-1 modulates muscle repair mechanisms preventing its uncontrolled accelerati

235 ethality and that in its absence alternative repair mechanisms promote cell survival.

236 We have found that the repair mechanisms propagated in the literature to this d

237 PARP in the context of defects in other DNA repair mechanisms provide a tumor specific way to kill c

238 tory profile that can accelerate deleterious repair mechanisms rather than support proper vascular re

239 ses RecA action and participates in some DNA repair mechanisms, RecBCD exonuclease, which degrades do

240 DNA damage repair mechanisms remained defective in these BRCA1 K898

241 cy of standard chemotherapy by targeting DNA repair mechanisms remains an important area of research.

242 In these cases, replication-coupled repair mechanisms remove the mistake or repair the templ

243 FA), for example, has elucidated a novel DNA repair mechanism required for maintaining genomic stabil

244 role for MTDH in male fertility and the DNA repair mechanisms required for normal spermatogenesis.

245 The second repair mechanism requires replication fork convergence,

246 ion of N(6)-CMdA, suggesting the presence of repair mechanism(s) for the rapid clearance of this lesi

247 Repair mechanisms such as ingrowth of RPE/drusenoid mate

248 ial DNA (mtDNA), which has far less reliable repair mechanisms than chromosomal DNA, might produce ne

249 ystematically faster compensation and damage repair mechanisms than individual tolerance.

250 Thus, BRCA1/SETX complexes support a DNA repair mechanism that addresses R-loop-based DNA damage

251 ponse (DDR) is a DNA damage surveillance and repair mechanism that can limit the effectiveness of rad

252 process lead to activation of an alternative repair mechanism that depends on MUS81-catalyzed cleavag

253 steps of base excision repair, the principal repair mechanism that identifies and removes endogenous

254 ting chromosome breakage and elucidate a DNA repair mechanism that is critical to maintain chromosome

255 G repeats may be mediated by a recombination-repair mechanism that is influenced by DNA structure.

256 t pathway is a conserved and fundamental DNA repair mechanism that protects the genome from genotoxic

257 tress, impacting gene expression via the DNA repair mechanism that reads and ultimately erases the ox

258 excision repair (TC-NER) is an important DNA repair mechanism that removes RNA polymerase (RNAP)-stal

259 lication (BIR), a genome rearrangement-prone repair mechanism that requires the Pol32/POLD3 subunit o

260 Revascularization is an adaptive repair mechanism that restores blood flow to undersuppli

261 metazoans possess robust homology-dependent repair mechanisms that can be harnessed for recombineeri

262 otentially deleterious homology-directed DSB repair mechanisms that can impair genome integrity.

263 and increases utilization of error-prone DNA repair mechanisms that could contribute to disease progr

264 Focal cerebral ischemia initiates self-repair mechanisms that include the production of neurotr

265 n important component of double-stranded DNA-repair mechanisms that interacts with both BRCA1 and BRC

266 Maladaptive repair mechanisms that persist following the acute phase

267 type 2 ILCs (ILC2s) have been implicated in repair mechanisms that restore tissue integrity after in

268 ) coordinate cell cycle checkpoints with DNA repair mechanisms that together maintain genome stabilit

269 In combination with DNA repair mechanisms, the system produces targeted mutation

270 in mussels suggesting that ACC is used as a repair mechanism to combat shell damage under OA.

271 ondria lack a functional nucleotide excision repair mechanism to repair DNA adducts and are sensitive

272 a model for testing the contribution of DNA repair mechanisms to cisplatin ototoxicity.

273 CRISPR-Cas9 and endogenous homology-directed repair mechanisms to convert heterozygous genotypes to h

274 e target gene sequences and then utilize DNA repair mechanisms to permit precise yet versatile geneti

275 tes the efficiency and fidelity of major DSB repair mechanisms to protect leukemia cells from apoptos

276 inst ribonucleotides, and by the capacity of repair mechanisms to remove incorporated ribonucleotides

277 tely, hematopoietic cells have sophisticated repair mechanisms to suppress such translocations.

278 Little was known about DPC-specific repair mechanisms until the recent identification of a D

279 toenzymatic repair (PER) is an important DNA repair mechanism used by marine microorganisms occupying

280 tioner caspase activation is a normal tissue repair mechanism usurped to promote oncogene-driven over

281 model, the impact of hyperglycemia on brain repair mechanisms was investigated.

282 TOPO-II-alpha), which is associated with DNA repair mechanisms, was also overexpressed by these cells

283 Despite differences in the replication and repair mechanism, we show that the human polymerase effi

284 and for proteins involved in DNA damage and repair mechanisms, we conclude that the lack of PTIP res

285 ally, differences in these PSC-dependent NMJ repair mechanisms were MU type dependent, thus reflectin

286 hin a genome is crucial to understanding the repair mechanisms which protect this integrity.

287 ed an ever more detailed dissection of these repair mechanisms, which are described here.

288 nuclear rupture and activation of DNA damage repair mechanisms, which are rescued by exogenous reexpr

289 unately, FTKs compromise the fidelity of DNA repair mechanisms, which contribute to the accumulation

290 the genomes of cancer cells may enhance DNA repair mechanisms, which in turn limit the accumulation

291 argeting this complex thanks to an efficient repair mechanisms, while if PSI is affected, there are d

292 ions by activating cell cycle checkpoint and repair mechanisms, while multicellular animals have acqu

293 eactivity was complicated by the presence of repair mechanisms whose extent and relative importance w

294 e our understanding of stem cell biology and repair mechanisms will provide a platform for therapeuti

295 air is an important and highly conserved DNA repair mechanism with an exceptionally large range of ch

296 cation of injection, which suggests that any repair mechanism with this disease model must trigger a

297 lar response to DNA damage, thus linking DNA repair mechanisms with DNA methylation.

298 ionizing radiation despite sharing most DNA repair mechanisms with other eukaryotes.

299 e functional interplay between SIRT6 and DNA repair mechanisms, with implications for both tumorigene

300 ite expansion, and describe an inherent self-repairing mechanism working against expansion.