ライフサイエンスコーパス: repair of

1 Cas9-mediated cleavage and NHEJ-mediated DSB repair of 6872 synthetic target sequences, introduced in

2 ed genes, and error-free double-strand break repair of a 3'-phosphate-containing terminally gapped, l

3 We also determined MutY-mediated repair of A analogues paired with OG within the context

4 s (GFs), the nSC scaffolds induce successful repair of a critical-sized calvarium defect in a rabbit

5 esses that counteract its activity along the repair of a DNA adduct.

6 sphorylation is controlled by PP4 during the repair of a DNA lesion and demonstrate that the attenuat

7 avoid Rad53 hyper-phosphorylation during the repair of a double-strand break, a process that impacts

8 One of the most central questions about the repair of a double-strand DNA break (DSB) concerns how t

9 a mechanistic basis for the homeostasis and repair of a fast-turnover ectodermal appendage.

10 ohort of 141 patients who underwent surgical repair of a full-thickness rotator cuff tear at a single

11 d 18 years and older with open anterior mesh repair of a primary inguinal hernia between January 1, 2

12 women were included, of whom 2113 underwent repair of a primary ventral hernia.

13 istone H3 (H3K18 and H3K27) and measured the repair of a site-specifically positioned 2'-deoxyuridine

14 es in both replication of the genome and the repair of a wide range of lesions.

15 ves genome integrity by promoting error-free repair of abasic sites in single-stranded DNA.

16 transcription factors, are caused by faulty repair of abasic sites.

17 However, the repair of acetaldehyde-induced crosslinks results in inc

18 ytosing microglia/macrophages determines the repair of acutely demyelinated lesions.

19 (+)CD4(+) regulatory T (Treg) cells promotes repair of acutely or chronically injured skeletal muscle

20 novel approaches to enhance maintenance and repair of aged or diseased tissues.

21 ne the transient kinetics of recognition and repair of alkylated DNA by AlkB.

22 stent with an expanded role of yeast Mag1 in repair of alkylation damage.

23 Elective endovascular repair of an abdominal aortic aneurysm results in lower

24 During follow-up, repair of an aneurysmal evolution of the false lumen dis

25 unclear etiology after abdominal surgery for repair of an aortic aneurysm requiring multiple therapeu

26 ngle patient who died of COVID-19 after open repair of an aortic dissection, complicated by hypoxic r

27 Discovery and repair of an evolutionarily lost lipid A modifying enzym

28 he 8% MDM scaffolds promoted the integrative repair of an in vitro meniscal defect.

29 em cells that is known to participate in the repair of an injured tooth, and its properties can be af

30 case of chronic retinal detachment following repair of an open globe injury were examined immunohisto

31 had 34% reduced odds of receipt of surgical repair of an RRD (odds ratio [OR] 0.66, 95% confidence i

32 Compared with non-mesh repair, mesh repair of anterior compartment prolapse was associated w

33 ndard MRI showed incomplete cartilage defect repair of apoptotic MASIs at 24 weeks.

34 lerosis progression and leads to a defect in repair of arteries after cholesterol reduction, a proces

35 eks after infection between the frequency of repair of attenuated Nef-STOP virus to pathogenic Nef-OP

36 The repair of base lesions generally requires five enzymatic

37 e effects on bone regeneration when used for repair of bone defects.

38 e (AAG) is thought to initiate base excision repair of both 1,N (6)-ethenoadenine (eA) and 1,N (2)-et

39 sistent with this, PNKP is implicated in the repair of both DNA single-strand breaks (SSBs) and DNA d

40 uently insufficiently processive to complete repair of breaks in microhomology-poor, AT-rich regions.

41 hers result from DNA replication or aberrant repair of breaks in sequence-specific contexts.

42 Repair of broken DNA by homologous recombination require

43 quence-specific restriction modification and repair of bulky adducts and interstrand crosslinks.

44 the coding CTG strand and arise by blocking repair of CAG slip-outs.

45 bioprinting is a promising approach for the repair of cartilage tissue after damage due to injury or

46 are a better candidate than PA MSCs for the repair of cartilaginous tissue.

47 Compared to the Late group, Early repair of CDH on ECMO was associated with a lower mortal

48 ERCC1-XPF is primarily involved in the repair of chemically induced helix-distorting and bulky

49 was to evaluate the outcome of endovascular repair of chronic aortic arch dissecting aneurysms with

50 d cell cycle checkpoints in combination with repair of cisplatin-DNA lesions in vivo using RNAi nanoc

51 ltered mutational spectrum compared with the repair of cisplatin-induced crosslinks.

52 cAMP-enhanced repair of cisplatin-induced DNA damage was dependent on

53 ecules that may be further optimized for the repair of CNS damage.

54 NB3 are annealing helicases that mediate the repair of collapsed DNA replication forks.

55 ntration of ATP, likely performs its role in repair of complex 8OG-containing DSBs using ribonucleoti

56 editing of genomic DNA can be achieved upon repair of CRISPR-induced DNA double-stranded breaks (DSB

57 Healthy repair of cutaneous injury is a coordinated response of

58 rs directly controlling the accumulation and repair of damage are the most important factors affectin

59 , cohesin and condensin activity inhibit the repair of damage caused by DNA topological stress.

60 of enzymes and protein cofactors that hasten repair of damaged DNA bases.

61 2-Phosphoglycolate is generated during repair of damaged DNA ends, 2-phospho-L-lactate is a pro

62 adiation resistance is enhanced by efficient repair of damaged DNA.

63 vely inhibits Th17 accumulation and promotes repair of damaged intestinal epithelium in inflamed colo

64 The repair of damaged Ni-based superalloy single-crystal tur

65 mechanisms that facilitate stabilization and repair of damaged sarcolemmal membranes following myocar

66 fficacy in BRCA1-deficient cells and altered repair of damaged telomeres, can be explained from this

67 undamental process in normal development and repair of damaged tissues and organs.

68 Observational study including primary repairs of degenerative AAAs in the Netherlands between

69 The proper repair of deleterious DNA lesions such as double strand

70 stimulation of sterol synthesis boosted the repair of demyelinated lesions, suggesting novel therape

71 are crucially involved in the formation and repair of demyelinated lesions.

72 otection and restoration of function through repair of demyelinated lesions.

73 ates with FANCD2 to promote the HR-dependent repair of directly induced DNA double-stranded breaks.

74 These observations suggest that the repair of distinct damages induced during diverse transc

75 encing (XR-seq) to study nucleotide excision repair of DNA adducts in humans, mice, Arabidopsis thali

76 ordinates the identification, signaling, and repair of DNA damage caused by endogenous or exogenous f

77 Nucleosomes inhibit excision repair of DNA damage caused by ultraviolet (UV) light, a

78 Accurate and efficient repair of DNA damage preserves genome integrity, which i

79 The repair of DNA damage requires the ordered recruitment of

80 irradiation is dependent upon EGFR-mediated repair of DNA damage via activation of DNA-PKcs.

81 chromosome segregation, gene expression, and repair of DNA damage.

82 stability, which results from the inaccurate repair of DNA damage.

83 n cells as essential for the recognition and repair of DNA damage.

84 d essential for both DNA replication and the repair of DNA damage.

85 t to Prkdc, a gene involved in detection and repair of DNA damage.

86 BER) maintains genomic stability through the repair of DNA damage.

87 ng to deficiency in homologous recombination repair of DNA damage.

88 prioritize completion of cell division over repair of DNA damage.

89 The repair of DNA double strand breaks (DSBs) that arise fro

90 ted during the homologous recombination (HR) repair of DNA double strand breaks (DSBs).

91 ll living organisms that allows the faithful repair of DNA double strand breaks, through the exchange

92 Repair of DNA double-strand breaks (DSB) is performed by

93 to operate in homologous recombination (HR) repair of DNA double-strand breaks (DSB); however, its p

94 A proper balance between the repair of DNA double-strand breaks (DSBs) by homologous

95 mation of new replication origins (cSDR) and repair of DNA double-strand breaks (DSBs) in E. coli sha

96 Timely repair of DNA double-strand breaks (DSBs) is essential t

97 Efficient repair of DNA double-strand breaks (DSBs) is of critical

98 Repair of DNA double-strand breaks (DSBs) must be orches

99 Efficient repair of DNA double-strand breaks (DSBs) requires a coo

100 tic crossovers result from homology-directed repair of DNA double-strand breaks (DSBs).

101 ions from generation of genetic diversity to repair of DNA double-strand breaks (DSBs).

102 RAD9A, two proteins that facilitate accurate repair of DNA double-strand breaks and prevent chromosom

103 In the repair of DNA double-strand breaks by homologous recombi

104 The repair of DNA double-strand breaks by homologous recombi

105 Repair of DNA double-strand breaks by the nonhomologous

106 Repair of DNA double-strand breaks have been shown to en

107 s recombination (HR) mediates the error-free repair of DNA double-strand breaks to maintain genomic s

108 In bacteria, repair of DNA double-strand breaks uses a highly conserv

109 s has revealed mechanisms of recognition and repair of DNA double-strand breaks, DNA interstrand cros

110 PK) has been shown to play a crucial role in repair of DNA double-strand breaks, facilitating nonhomo

111 ed by RecBCD proteins often enables accurate repair of DNA double-strand breaks.

112 ta (Pol zeta) and Rev1 are essential for the repair of DNA interstrand crosslink (ICL) damage.

113 oteins FANCI and FANCD2, is required for the repair of DNA interstrand crosslinks (ICL) and related l

114 e tumor suppressor BRCA1, is crucial for the repair of DNA interstrand crosslinks (ICL), a highly tox

115 monoubiquitination, an essential step in the repair of DNA interstrand crosslinks.

116 r machinery fulfill overlapping roles in the repair of DNA lesions, the mechanisms coordinating diffe

117 dicines, firefly luminescence, and reductive repair of DNA photodamage.

118 The repair of DNA strand breaks improves, as do serum protei

119 densin are linked to both the generation and repair of DNA topological-stress-linked damage in these

120 is essential for chromosome segregation, the repair of DNA-damage, and the regulation of gene express

121 lear metalloprotease that is involved in the repair of DNA-protein crosslinks (DPCs).

122 important role in double-strand break (DSB) repair of DNA.

123 st, transcript RNA was shown to template DSB repair of DNA.

124 Repair of double strand DNA breaks (DSBs) can result in

125 SSA) is thought to mediate homology-directed repair of double-strand breaks (DSBs) between two repeat

126 ing nonhomologous end joining (NHEJ) for the repair of double-strand breaks (DSBs) caused by reactive

127 on, an essential step for homology-dependent repair of double-strand breaks (DSBs), and by attenuatin

128 A replication, high-level transcription, and repair of double-strand breaks coalesce into foci, altho

129 Bacterial recombinational repair of double-strand breaks often begins with creatio

130 ligation, revealing the initial step in the repair of double-strand DNA breaks.

131 , the maintenance of telomeres and rDNA, and repair of double-stranded breaks (DSBs) induced by genot

132 /2-mutant tumours are often deficient in the repair of double-stranded DNA breaks by homologous recom

133 rates with Mre11 and Rad50 to coordinate the repair of double-stranded DNA breaks.

134 t TDP1 defines a minor backup pathway in the repair of DPCs.

135 to allowing direct acetylation by PCAF, and repair of DSBs by homologous recombination.

136 e conditions, we find that homology-directed repair of DSBs is delayed, indicating antagonism between

137 Therefore, efficient repair of DSBs is especially vital for maintaining cellu

138 52 protein played only a back-up role in the repair of DSBs performing an error-prone single strand a

139 phase that promotes DSB formation and biases repair of DSBs to homologs over sister chromatids.

140 chromatin, permitting correct placement and repair of DSBs.

141 cally disordered protein RBM14 for efficient repair of DSBs.

142 of DNA damage factors and homology directed repair of dysfunctional telomeres lacking POT1-TPP1.

143 the knockout of disease-causing genes or the repair of endogenous mutated genes.

144 While A-EJ-mediated repair of endonuclease-generated breaks requires DNA end

145 een preliminarily reported in patients after repair of esophageal atresia (EA), but the basis of this

146 sed outcomes of thoracoscopic to thoracotomy repair of esophageal atresia.

147 rther modified the method to measure precise repair of excision junctions and allele-specific excisio

148 Mechanisms underlying the repair of extrahepatic biliary tree (EHBT) after injury

149 acterial survival, but it remains unclear if repair of Fe-S clusters is also important for bacterial

150 le printing approach may be used towards the repair of focal defects in articular cartilage or broadl

151 w that ssDNA intermediates formed during the repair of gamma-induced bursts of double-strand breaks (

152 control of the cell cycle allows for timely repair of genetic material prior to replication.

153 n extreme old age, with implications for the repair of geriatric muscle.

154 ity replication, chromosome segregation, and repair of germ cell genomes remain incompletely understo

155 ruption of gut epithelium and explored rapid repair of gut epithelium at the intersection of microbia

156 mammalian hair cells do not regenerate, the repair of hair cell damage is important for continued au

157 ocessed and toxic joint DNA molecules during repair of ICL-induced DNA damage.

158 ed with ODP, conversion in 62.2%, surgically repair of incisional hernias in 21% after LDP, or an ave

159 nique allows minimally invasive transhernial repair of incisional hernias using large retromuscular/p

160 The repair of inflamed, demyelinated lesions as in multiple

161 l progenitor cells [sprocs]) with diminished repair of injured LSECs and whether restoring signaling

162 e study shows that capillarization is due to repair of injured LSECs by BM endothelial progenitors th

163 h of neurites is important for enhancing the repair of injured nerves and understanding the developme

164 or challenge in regenerative medicine is the repair of injured neurons.

165 nti-inflammatory molecules to accelerate the repair of injured or diseased tissues.

166 nse to injury, but they are also involved in repair of injury.

167 nate immune response to injury as well as in repair of injury.

168 EVAR should be considered the first line for repair of intact descending thoracic aortic aneurysms in

169 We studied all repairs of intact or symptomatic cAAA in the Vascular Qu

170 al stem cell (MSC) therapy to accelerate the repair of ischemically damaged human kidneys during 24 h

171 igh-strength bioactive scaffolds for in-situ repair of large bone defects is challenging because of t

172 The repair of large cranial defects with bone is a major cli

173 been reported in up to 30% of patients after repair of large hiatus hernias, and mesh repair has been

174 est a model where BAF is critical for timely repair of large ruptures in the nuclear membrane, potent

175 relies exclusively on prophylactic operative repair of larger aneurysms.

176 Microglial repair of leaky blood vessels was blocked by a peptide t

177 of the viral genome, which is formed by the repair of lesion-bearing HBV relaxed circular DNA delive

178 latform for ex vivo assessment and potential repair of marginal organs.

179 Nevertheless, repair of mC deamination is important because the result

180 herichia coli However, we found that in vivo repair of methyl methanesulfonate (MMS)-induced alkylati

181 gamma is responsible for the replication and repair of mitochondrial DNA (mtDNA).

182 In this adequately powered randomized trial, repair of mitral prolapse with either leaflet resection

183 flet resection and preservation for surgical repair of mitral regurgitation caused by prolapse.

184 C, whereas Rdh54 retains its function in the repair of MMS-induced DNA damage even when recruited to

185 clinically relevant treatment strategy aids repair of motor circuits after SCI.

186 ollapsed replication forks, and mediates the repair of multiple classes of DNA lesions.

187 ratase (NAXD) is essential for intracellular repair of NAD(P)HX.

188 of BER intermediates that occurs during the repair of naked DNA substrates differs significantly fro

189 The requirement for DksA in repair of nalidixic acid (Nal)-induced DSBs or for the f

190 ologue, Ddes_1165, that is implicated in the repair of nitrosative damage.

191 al a new role for BAF in the response to and repair of nuclear ruptures.

192 eficient cancers, indicating that asymmetric repair of nucleosomal DNA imposes a strand polarity on U

193 tric acid (CA) and tetracycline (TCN) on the repair of onlay bone grafts.

194 the base excision repair pathway during the repair of opposing base damage, and in particular DNA po

195 CD271+ MSCs and improved early stage tissue repair of osteochondral lesions when transplanted, along

196 n, with implications for the maintenance and repair of other barrier tissues.

197 t play a central role in the maintenance and repair of our bones are formed from bone marrow myeloid

198 cision repair (BER) is the major pathway for repair of oxidative DNA base damage 8-oxoguanine (8-oxoG

199 pendent PAR stabilization promotes efficient repair of oxidative DNA damage.

200 use MUTYH has a well-established role in the repair of oxidative DNA lesions.

201 sylases/lyases NEIL1 and NEIL2, which act in repair of oxidative lesions and in epigenetic demethylat

202 of PARP1 auto-ADP-ribosylation and defective repair of oxidative lesions, in cells with increased Ban

203 S have defective PARP1 activity and impaired repair of oxidative lesions.

204 insight into Banf1-regulated, PARP1-directed repair of oxidative lesions.

205 PNKP; an XRCC1 protein partner important for repair of oxidative SSBs.

206 Proper repair of oxidatively damaged DNA bases is essential to

207 outcomes negatively, particularly if primary repair of patients with open-globe injuries is delayed.

208 these LMC progenitors during maintenance and repair of PLVs, along with their function in other lymph

209 glycosylase (tag) genes responsible for the repair of point mutations.

210 recombination factor required for efficient repair of PRDM9-dependent DSBs and for pairing of homolo

211 mic and visual outcomes in both TPR and NTPR repair of primary RD.

212 as a mediator of the RAD51 recombinase in HR repair of programmed DNA double-strand breaks (DSB).

213 hromosome rearrangements are mediated by the repair of programmed DNA double-strand breaks (DSBs) as

214 g meiotic recombination, homologue-templated repair of programmed DNA double-strand breaks (DSBs) pro

215 Crossovers arise from recombination-mediated repair of programmed DNA double-strand breaks (DSBs).

216 Crossovers generated during the repair of programmed meiotic double-strand breaks must b

217 We suggest that new origin formation and DNA repair of protein adducts with DSBs may both involve the

218 at this group of proteins is not involved in repair of protein isoD residues.

219 xpression regulation and also influences the repair of radiation-induced DNA damage.

220 much of the cell cycle, is an impediment to repair of radiation-induced lesions in this organism, an

221 lights the relevance of this pathway for the repair of radiotherapy-induced damage.

222 e Hedgehog (Hh) pathway, is required for the repair of rDNA DSBs.

223 les into a thermoplastic polymer enables the repair of regions damaged by electrical treeing and the

224 CSB and RAD52 are required for the efficient repair of ROS-induced telomeric DSBs.

225 l in 2019 United States dollars) for primary repair of RRD in facility and nonfacility settings were

226 ss whether sex-related differences in timely repair of ruptured abdominal aortic aneurysm (rAAA) were

227 a protein involved in adaptive response and repair of S (p)-Me-PTE in E. coli, however, was essentia

228 Repair of similar DSBs via single-strand annealing of sh

229 othesis that PARP inhibition will impair the repair of single stranded breaks, causing synthetic leth

230 tween DNA polymerases and DNA ligases in the repair of single- and double-strand DNA breaks, and disc

231 te and locally deliver essential factors for repair of single-strand DNA breaks in replication region

232 important in wound healing, we examined the repair of skin wounds in knockout (KO) mice lacking cPLA

233 ntial targets to improve the maintenance and repair of spinal tissues.

234 n is required for maintaining ploidy and the repair of spontaneous DNA damage in placental cells, sug

235 damage is thought to arise from the aberrant repair of spontaneous replication stress, however succes

236 Fourth, PTMs take part in the repair of stress-induced damage (e.g., by reducing Met a

237 Repair of such damage by tyrosyl DNA phosphodiesterase 2

238 Defective repair of such oxidative damage in the fertilized oocyte

239 mice of both sexes, suggest that spontaneous repair of synapses after noise depends on the level of V

240 P7C3-A20, electron microscopy revealed full repair of TBI-induced breaks in cortical and hippocampal

241 t ATRX deletion from mouse cells altered the repair of telomeric double-strand breaks (DSBs) and indu

242 Thus, ROS-induced telomeric R-loops promote repair of telomeric DSBs through CSB-RAD52-POLD3-mediate

243 ragile telomeres can arise from BIR-mediated repair of telomeric DSBs.

244 addition, we document a role for DAXX in the repair of telomeric DSBs.

245 y-five patients aged median 12.0 years after repair of tetralogy of Fallot and similar lesions were s

246 the role of two demineralizing agents in the repair of the 8-mm critical-size defects in rats' calvar

247 urysms to either endovascular repair or open repair of the aneurysm.

248 nor myeloid recovery is necessary for timely repair of the BBB.

249 from the O (6) position of guanine, whereas repair of the branched-chain lesions relied on nucleotid

250 nes and human primary cells and demonstrated repair of the clinically relevant PiZZ mutation, which c

251 mechanisms that underlie the maintenance and repair of the continuously growing mouse incisor.

252 The Y-family DNA polymerase REV1 completes repair of the crosslink, culminating in a distinct mutat

253 o cause single-cell damage in gastroids, and repair of the damage was monitored over time; complete r

254 l enrichment selectively enhances endogenous repair of the developing white matter by promoting oligo

255 Proper function and repair of the digestive system are vital to most animals

256 eling, cell-cycle checkpoint activation, and repair of the DSB.

257 nal protective effects of retinoic acid, and repair of the endogenous retinoic acid pathway offers an

258 Repair of the endothelial cell barrier after inflammator

259 Strategies are needed for rapid repair of the epithelium to protect intestinal microenvi

260 role of developmental proangiogenic cues in repair of the established vasculature is largely unknown

261 roteinases with critical roles in damage and repair of the extracellular matrix.

262 conclusion, acute GVHD damages and prevents repair of the FRC network, thus disabling an essential p

263 Upon injury, repair of the gastrointestinal barrier is mediated by co

264 Here we show that repair of the inactivated C16L/B22R gene of MVA enhances

265 Cholecystectomy and Bassini's repair of the inguinal hernia were performed safely.

266 The ensuing in situ repair of the interface by electrolyte, either regenerat

267 induces a significant delay in recovery and repair of the intestinal epithelium of up to 2 wk post t

268 and circulating cell types during injury and repair of the kidney.

269 sferase (MGMT) is responsible for the direct repair of the main TMZ-induced toxic DNA adduct, the O6-

270 e position of target elements and subsequent repair of the nicked phosphate backbone that remains fol

271 adian clock with a single phase at which the repair of the nontranscribed strand (NTS) and the rest o

272 after 2 days, whereas weeks are required for repair of the NTS and the rest of the genome.

273 insertion of a ST-AMG for reconstruction or repair of the ocular surface.

274 urodegenerative disorders are focused on the repair of the primary affected cell type.

275 ogenitors needed for growth, maintenance and repair of the skeleton.

276 cells are potential targets to improve self-repair of the spinal cord.

277 e negative pressure device immediately after repair of the surgical incision (n = 816), or receive st

278 via transcription-directed repair, controls repair of the transcribed strand (TS) of these genes in

279 Repair of the traumatically injured brain has been envis

280 ablish a role for the RecQ4 helicases in the repair of these detrimental DNA lesions.

281 an cells sense the presence and regulate the repair of these lesions, we employed a quantitative prot

282 e distorted by the error-prone or error-free repair of these uracils and by selection pressures.

283 We recently showed that, in mice, repair of this adduct 2 h following injection is control

284 Upon repair of this polymorphism to the sequence present in Y

285 Angiogenesis is a critical process in repair of tissue injury that is regulated by a delicate

286 consider mechanisms that facilitate healthy repair of tissue injury.

287 fore an important layer of regulation in the repair of TOP2 poison-induced DNA damage.

288 Here, we show that proteasome-mediated repair of TOP2cc is highly error-prone.

289 the alarmone molecule is dispensable for the repair of topoisomerase type II (Top II) DNA adducts and

290 ignificantly decreased global transcription, repair of transcribed genes, and error-free double-stran

291 showed omega-3 fatty acid (omega-3)-mediated repair of unfolded protein response and here we show muc

292 we use genome-wide repair data to show that repair of UV damage in nucleosomes is asymmetric.

293 f genes in an asymmetric manner, with faster repair of UV damage occurring on the 5' side of the nucl

294 Repair of UV-induced DNA damage requires chromatin remod

295 of UV-induced DNA damage and stimulated the repair of UV-induced DNA damage.

296 Repair of virally induced oxidative damage by the DNA MM

297 associated with the generation of DSBs, the repair of which is likewise essential for the activation

298 olates harbor T6SS-abrogating mutations, the repair of which, in some cases, rendered the isolates re

299 There were 3719 rAAA repairs, of which 797 (21%) were performed in women.

300 The repair of white matter damage is of paramount importance