ライフサイエンスコーパス: repair response

1 ritical regulator of the cellular DNA damage repair response.

2 which might represent an intrinsic host CNS repair response.

3 ng in a saturation of DNA-PK-mediated damage repair response.

4 ing potential mechanisms for this endogenous repair response.

5 hase checkpoint and for efficient DNA damage repair response.

6 n to be the initiator of the endogenous bone repair response.

7 romatic regions of the genome and in the DNA repair response.

8 s Mdm2 to the Mre11-Nbs1-Rad50-regulated DNA repair response.

9 fission at the injury site help polarize the repair response.

10 the initial stages of the wound defense and repair response.

11 to examine a potential role for WRN in this repair response.

12 checkpoints is essential to a robust damage-repair response.

13 l was adapted for mice to study the fibrotic repair response.

14 t growth factor mediators participate in the repair response.

15 specific signals to activate the appropriate repair response.

16 in macrophages, which orchestrate the tissue repair response.

17 cal to the mammalian DNA double-strand break repair response.

18 gated by a poorly characterized, maladaptive repair response.

19 protein that presides over the cell membrane repair response.

20 ivating an endogenous, germline-specific DNA repair response.

21 ment with fibronectin restored the epidermal repair response.

22 ouble-strand breaks (DSBs) and trigger a DNA repair response.

23 idermis are the primary signal inducing this repair response.

24 ted gene 45, two molecules linked to the DNA repair response.

25 ebride the site of injury and coordinate the repair response.

26 man skin and is an important part of a wound repair response.

27 blebbing, lysosomal exocytosis, and membrane repair response.

28 ges are critical in orchestrating the tissue-repair response.

29 int signaling due to the double-strand break repair response.

30 nappropriately activating the DNA damage and repair responses.

31 evealed Clld7 target genes that regulate DNA repair responses.

32 regarding the potential function of P2RX7 in repair responses.

33 required for appropriate DSB recruitment and repair responses.

34 tory responses and less well-understood host repair responses.

35 of genes involved in inflammation and tissue-repair responses.

36 apy due to their ability to induce favorable repair responses.

37 riggers global epithelial-mesenchymal tissue repair responses.

38 on proxies for ineffectual epithelial injury/repair responses.

39 tant drivers of both inflammatory and tissue repair responses.

40 rocesses, including cellular development and repair responses.

41 ed in OS tumors, accompanied by enhanced DNA repair responses.

42 emonstrates the ability of SENP2 to tune DSB repair responses.

43 eries, focusing on double-strand break (DSB) repair responses.

44 ke in both central nervous system injury and repair responses.

45 thesis and degradation are key to initiating repair responses.

46 d control intestinal inflammation and injury/repair responses.

47 an important role in liver regeneration and repair responses.

48 NM uptake and, thus, varying DNA damages and repair responses.

49 l cells can create scars that inhibit neural repair responses.

50 persistent inflammation and defective tissue repair responses.

51 ment for p53 in regulating the base excision repair response, a novel finding of great potential impo

52 e of differentiated tissues and enhances the repair response after injury.

53 ll recruitment during the nascent biological repair response after myocardial damage.

54 ation is an essential process for mounting a repair response after myocardial infarction (MI).

55 nal macrophage production of critical tissue repair responses after damage.

56 at a single immune receptor is essential for repair responses after SCI, and the potential mechanisms

57 asmic reticulum calcium efflux, ROS, and DNA repair responses after UV irradiation.

58 asmic reticulum calcium efflux, ROS, and DNA repair responses after UV irradiation.

59 0/Nbs1 DNA repair complex, and a delayed DNA repair response all indicate that Runx2 deficiency leads

60 l functions of inflammatory cells during the repair response and compare data from other tissues, the

61 EcoRI methyltransferase induces the SOS DNA repair response and greatly reduces viability of recA56,

62 K4a in homologous recombination-mediated DNA repair response and imply p16INK4a status as an independ

63 ix-associated signaling propagates the wound repair response and promotes lung fibrosis characterized

64 n-resident T cells in the UVR-associated DNA repair response and underscore the importance of skin-re

65 e diseases are driven by dysregulated tissue repair responses and are a major cause of morbidity and

66 ir, and the connection between defective DNA-repair responses and specific neurological disease.

67 link SUMO modifying machinery to DNA damage repair responses and transcriptional modulation in neuro

68 ear site involved in DNA damage recognition, repair response, and cell cycle checkpoint activation.

69 ures for cell cycle regulation, inflammatory/repair response, and extracellular matrix (ECM) remodeli

70 roid formation, oxidative stress, DNA damage repair response, and mTOR signaling pathway in vitro.

71 iated with increased DNA damage, reduced DNA repair responses, and elevated cellular senescence.

72 age and molecular mechanisms underlying this repair response are incompletely understood.

73 ith wild-type bone marrow showed an improved repair response, as seen by a profound increase in proli

74 serve as an important mediator of growth and repair responses, associated with development of angioge

75 to the occurrence of inflammatory and injury/repair responses at different mucosal sites.

76 ng the activation of aberrant DNA damage and repair responses at telomeres.

77 To execute an appropriate repair response, BER components must be distributed to a

78 postischemic mouse kidneys and compared the repair response between control (wild-type) and muMT (B

79 te tumor suppressor that accelerates the DNA repair response, binds to androgen receptor at the ERG g

80 ssue injury is unlikely to contribute to the repair response but rather is a participatory factor in

81 hat activates not only homology-directed DNA repair responses but also cell cycle checkpoint control.

82 epidermis triggers an immune reaction and a repair response, but it is not clear how these are coord

83 -13 amplifies multiple aspects of the tissue repair response, but many of these pathways are highly r

84 re known to promote fibrosis, an overzealous repair response, but their contribution to healthy wound

85 in annexin A7 is part of the plasma membrane repair response by enabling assembly of the endosomal so

86 ccompanied by delayed induction of the nerve repair response by Schwann cells and delayed clearance o

87 RSL3 subdued DNA damage repair response by suppressing phosphorylation of nucleo

88 Thus, the lysosomal repair response can also protect cells against pathogens

89 a misdirected macrophage-orchestrated tissue repair response can result in chemoresistance, but in ot

90 greater matrix damage combined with a slower repair response could lead to injury propagation if relo

91 rleukin-1 family of cytokines in the barrier repair response, cytokine production was stimulated in a

92 Repair responses define the ultimate outcomes of liver d

93 iciency in fibrous tissues results in a poor repair response due to the accumulation of aggrecan in t

94 MR machinery and sustained by a constant DNA repair response, establishing a potential mechanistic li

95 Despite mobilizing the DNA repair response, even very low levels of DNA damage resu

96 rentiation and proliferation in the adaptive repair response following AKI.

97 Moreover, chondrocytes exhibit a potential repair response following this procatabolic stimulus suc

98 uences both susceptibility and nature of the repair responses following injury.

99 This is the first characterization of a DNA repair response from expression of a non-long terminal r

100 t tumors secrete factors that elicit a wound-repair response from TAMs and TANs and that this respons

101 BACH1 in controlling a broad spectrum of the repair response genes in macrophages upon injury.

102 he regulation of the DNA double-strand break repair response, genomic stability, and transformation t

103 inoglycoside damage paradigm, the epithelial repair response halted.

104 of the vertebrate nervous system and tissue-repair responses has hindered identification of the prec

105 stress induces apoE synthesis as part of the repair response; however, when apoE4 is expressed in neu

106 gion of cardiac infarction and can augment a repair response in damaged tissue.

107 ased ENMs induced relatively weak DNA damage repair response in E. coli, but more severe DNA double s

108 damage and the nature of the subsequent DNA repair response in germ cells, which ensures faithful tr

109 Studying this dysregulated tendon repair response in human pathophysiology has been histor

110 n the form of selenomethionine induces a DNA repair response in normal human fibroblasts in vitro, an

111 l suppression of mTOR pathway and DNA damage repair response in preclinical in vitro model of TC supp

112 egulates the extent of the innate neurogenic repair response in the SVZ after stroke.

113 KO tubular epithelial cells had an increased repair response in vitro, as seen by an increased abilit

114 The Ca(2+) flux triggers a wounded membrane-repair response in which internal vesicles, including ly

115 target cell that triggers a wounded membrane repair response in which lysosomes and endosomes donate

116 in the personalized management of injury and repair responses in critical illness.

117 ed role for ZEB1 regulating inflammatory and repair responses in dystrophic and acutely injured muscl

118 lay an important role in restricting dynamic repair responses in mammalian vestibular epithelia.

119 Tissue repair responses in metazoans are highly coordinated by

120 ng wing disc appears to cause non-autonomous repair responses in the neighbouring wild-type epitheliu

121 R) in asthmatic bronchial mucosa and studied repair responses in vitro.

122 w a possible mechanism for the inducible DNA repair response, in which enhanced repair complex format

123 toma SK-N-SH revealed that PGJ2 triggered a "repair" response including increased expression of heat

124 of genes involved in inflammatory and tissue-repair responses, including neutrophil-specific chemokin

125 atrix degradation that activates maladaptive repair responses, including pro-inflammatory pathways of

126 ng RNAiR5-bearing vectors showed far greater repair responses: increased neuronal proliferation, and

127 ates with greater matrix damage and a slower repair response increasing the risk of reinjury, and a f

128 radiation-induced DNA damage, integrate DNA repair responses into the cell cycle programme.

129 elial cells, triggering damage signaling and repair response involving ATM.

130 l, these studies identify how a dysregulated repair response involving interactions between IL-33+ fi

131 is and other stratified epithelia triggers a repair response involving the rapid induction of several

132 B-cell permeabilization triggers PM repair responses involving lysosomal exocytosis, and B-c

133 , and one of the key signals initiating this repair response is a decrease in the concentration of ca

134 The cell wound repair response is an example of how specific pathways c

135 standing the variable central nervous system repair response is crucial to identifying "at risk" infa

136 The bladder epithelial repair response is cumulative and aberrant as, after mul

137 A conserved DNA repair response is defective in the human genetic illnes

138 et-cell membrane integrity by triggering the repair response is necessary for target cells subjected

139 The induction of a DNA repair response is protective against Abeta42 toxicity,

140 However, this endogenous repair response is suboptimal and may account for the pe

141 for ATM/ATR activity, we found that the DSB repair response is surprisingly dynamic at the site of D

142 Mice lacking SFRP1 exhibited a rapid repair response leading to aberrant proliferation of dif

143 We propose that these differential DNA repair responses maintain the unique structure that defi

144 Triggering of the membrane repair response may help cells to replace distorted plas

145 ers following seizures suggests that the DNA repair response may not be sufficient to prevent excitot

146 Components of the cellular DNA damage repair response may represent potential targets for anti

147 odulatory actions, while abnormal epithelial repair responses may contribute to remodelling of the ai

148 hanisms that affect ECM composition and cell repair responses may facilitate the development of nonan

149 m of disease severity; however, dysregulated repair responses may lead to chronic lung dysfunction.

150 s likely a key component of inflammatory and repair response mechanisms, and involves the processing

151 The repair response must re-establish the epithelial barrier

152 se alterations may contribute to the delayed repair response of aging.

153 The purpose of this study was to compare the repair response of bioactive glass synthetic bone graft

154 pulation of oxygen levels might equalize the repair response of each tissue, we exposed mice to hyper

155 itope in hip OA cartilage indicates a lesser repair response of hip OA compared with knee OA cartilag

156 Therefore, SigG does not control the DNA repair response of M. tuberculosis H37Rv.

157 on-resolving lipid mediators and induced the repair response of synovial fibroblasts in vitro.

158 tive and qualitative biosensor of the injury repair response of the heart.

159 However, the anti-viral and repair responses of the bronchial epithelium in children

160 tolerate oxidative stress, cells enable DNA repair responses often sensitive to poly(ADP-ribose) (PA

161 microcephaly genes implicated in either DNA repair responses or centrosomal function may act in comm

162 such as cell-cycle control, DNA-damage and -repair responses, p53 and HIF1alpha.

163 Hepatic regenerative/tissue repair responses prevail during the later stages of acut

164 a complex network of inflammatory and wound repair responses, prompting Dvorak's characterization of

165 but not hypertrophy, suggests that apoJ is a repair response protein.

166 associated proteins and increased DNA damage/repair response proteins.

167 igh depth exome sequencing of 124 DNA damage repair/response (repairome) genes in 63 tumors and match

168 orting OL myelination and limiting astrocyte repair responses, suggesting therapeutic strategies bala

169 m, but cells survive by mounting a polarized repair response targeted to the wound site.

170 unabated, MRN elicits a double-strand break repair response that blocks viral DNA replication and li

171 stromal, and BEC results in a dysmorphogenic repair response that eventually leads to cirrhosis.

172 a heightened basal and wound site DNA damage/repair response that is also common to classical regener

173 oss of ceramide synthase 4 induced a barrier repair response that largely recapitulates molecular pro

174 ion of the permeability barrier stimulates a repair response that leads to the restoration of barrier

175 tic cells evoke a persistent pseudo-membrane repair response that likely redistributes lysosomal-deri

176 nct processes: 1) induction of an epithelial repair response that maintains the protective barrier an

177 These DSBs induce an endogenous DSB repair response that results in small insertions or dele

178 apoptosis could activate a "pseudo"-membrane repair response that results in the fusion of lysosomes

179 Myocardial infarction (MI) induces a repair response that ultimately generates a stable fibro

180 response and precedes the tissue renewal and repair responses that are initiated by innate immune cel

181 ite a compensatory transcriptional epidermal repair response, the protective epidermal function was i

182 geted pharmacologically to modulate survival/repair responses, the transport inhibitor N-(4-hydroxyph

183 erase (PARP) plays a significant role in DNA repair responses; therefore, this enzyme is targeted by

184 al role in regulating the early inflammatory repair response to acute myocardial injury by facilitati

185 venile mice, which may impact the injury and repair response to brain trauma.

186 BM SPC recruitment is a repair response to dimethylnitrosamine liver injury in r

187 n-edited strand, manipulate the cellular DNA repair response to favour desired base-editing outcomes,

188 The tissue repair response to hypoxic stimuli during wound healing

189 ssion of 394 transcripts associated with the repair response to injury, including many epithelium-lik

190 histones, are likely to cripple the cellular repair response to promote cell death in this novel casp

191 e I (TOP1) has been suggested to be a unique repair response to TOP1-mediated DNA damage.

192 as well as being rate-limiting in the tissue repair response to wounding and during cancer progressio

193 ter are related to aberrant regeneration and repair responses to acute death of premyelinating late o

194 oliferation and ductular reaction, which are repair responses to cholestatic injury.

195 se, but also modulates tissue remodeling and repair responses to endogenous ligands released during l

196 regulating damage-associated checkpoint and repair responses to HSP90 inhibitors, and identify BRCA1

197 in inflamed colon, neutrophils shape the DSB-repair responses to impact CRC progression and sensitivi

198 factor-beta signaling pathways that mediate repair responses to injuries.

199 ed individuals often demonstrate exaggerated repair responses to injury.

200 ution of macrophage HO-2 to inflammatory and repair responses to injury.

201 s are required for cell cycle checkpoint and repair responses to ionizing radiation, implicating ubiq

202 counted for 70% of all calcium ion-dependent repair responses to streptolysin O and perfringolysin O,

203 , but relatively little role for p21, in DNA repair responses to UV radiation.

204 Here we show that the beneficial DNA repair response triggered by these two genome caretakers

205 drial matrix and activate nuclear DNA damage/repair responses via interferon-stimulated gene products

206 le arrest in G2/M phase and an increased DNA repair response were observed in IR-exposed miR-15b/16-2

207 (MMS), suggesting that PARP activity and DNA repair responses were impaired.

208 escence do not exhibit a BRCA1-dependent DNA repair response when exposed to DNA damage.

209 catalytic activity to mount a cell survival repair response, whereas persistent PARP-1 hyperactivati

210 TM is primarily required for the meiotic DSB repair response, which includes functions in DNA damage

211 ther hand underpinning beneficial epithelial repair responses, which may confound responses in clinic

212 dult ECs survive through a plasmalemmal self-repair response, while neonatal ECs are predisposed to d

213 Stress pathways coordinate a cytoprotective repair response, while simultaneously initiating signali

214 respiratory viruses may impede or alter the repair response will be important areas of research for

215 survival first phase of the HIF1alpha injury repair response with metabolism and the mitochondrial ne

216 However, this damage also stimulates DNA repair responses with subsequent blocks to cell prolifer

217 The loss of auditory hair cells triggers repair responses within the population of nonsensory sup