ライフサイエンスコーパス: repeat

1 0 and the base pair A43-U66 in the GAUC/GAUC repeat.

2 g methylation status of X-linked polymorphic repeats.

3 noglobulin domain and alpha-actinin spectrin repeats.

4 of denaturation declined with the removal of repeats.

5 erestingly, Sig-1Rs directly bind (G4C2)-RNA repeats.

6 es+RG endfoot ratchets down, and the process repeats.

7 e glycoprotein with multiple O-glycosylation repeats.

8 nding element (EBE) consists of three direct repeats.

9 erize because their breakpoints map to large repeats.

10 amyloid formation upon deleting at least two repeats.

11 echanical unfolding of dystrophin's spectrin repeat 1 and related the changes in the protein's struct

12 s.HIV or placebo), and those injections were repeated 12 weeks later.

13 with cervical cancer underwent baseline and repeat (18)F-FDG PET/CT imaging within 7 d.

14 O-S binding sites to the microtubule binding repeat 2 (R2) and proline-rich region 2 (PRR2) of tau.

15 Imaging was repeated 6-8 wk after TACE.

16 This dynamic repeats across scales, forming remarkably strong, hierar

17 sex chromosomes contain multiple palindromic repeats across the non-recombining region that show sequ

18 s for treating immune-mediated diseases, but repeated administration can induce the formation of anti

19 apeutic protein expression in the absence of repeated administration of pharmacological agents.

20 efficiency of the purification levels during repeated adsorption desorption processes.

21 ts received 700mg leronlimab subcutaneously, repeated after seven days in 17/23 patients still hospit

22 nd developed tolerance to the sedation after repeated alcohol administrations.

23 Fifteen patients repeated all tests 12 months after the surgery.

24 xplored confirmatory re-testing scenarios of repeating all initial tests, initially positive tests, i

25 We repeated analyses using linear mixed models to examine a

26 e TRIO sequence, one in the seventh spectrin repeat and one in the RAC1-activating GEFD1.

27 cells transition between the two sites in a repeated and stochastic manner, and average dwell times

28 Winnowmap improves mapping accuracy within repeats and achieves these results with sparser sampling

29 tering strategy that has difficulty handling repeats and homology sequences.

30 p methylation patterns across complex tandem repeats and satellite arrays.

31 Here we describe how unexpanded CGG repeats and their translation play conserved roles in re

32 ), specific for N-acetyllactosamine (LacNAc) repeats, and previous studies have shown transport-depen

33 siRNAs corresponding to palindromic repeats are independent of the ADARs and ERI-6/7, and ar

34 Tandem repeats are proposed to contribute to human-specific tra

35 absence of WRN, the expanded TA-dinucleotide repeats are susceptible to cleavage by the MUS81 nucleas

36 ferent FapC variants with varying numbers of repeats as a function of the concentration of FA.

37 egating dipeptide repeat proteins (DPRs) via repeat associated non-AUG (RAN) translation.

38 94 miRNAs, 2197 miRNA-target genes, and 3730 repeat-associated siRNAs (mostly targeting Class I/Copia

39 processes and progressive downregulation of repeat-associated siRNAs following genome merger and gen

40 SPECT MBF was measured in 30 patients and repeated at a mean interval of 18 days.

41 elphis) was initially conducted in May 2017 (repeated August 2018).

42 Very short tandem repeats bear substantial genetic, evolutional, and patho

43 arriers also confer stability of the OLED to repeated bending and to extensive postprocessing, e.g. v

44 ival implant surface debridement followed by repeated bi-weekly supragingival plaque removal and chlo

45 ith a histologic activity index <=1 or >1 in repeated biopsies, respectively.

46 Repeated bolus injections are associated with higher cos

47 activity (MUA) in the cortex in response to repeated brief optogenetic stimulation of thalamocortica

48 nalysis indicates that several long-terminal-repeat bursts that occurred from 5.7 million years ago t

49 ered regularly interspaced short palindromic repeats)/Cas9 is evolving rapidly.

50 ered regularly interspaced short palindromic repeats-Cas9 (CRISPR-Cas9) and transposon vectors to dis

51 In vivo, HSCs were activated by repeated CCl(4) administration to rats every 3 days for

52 Participants made repeated choices between harmful and safe options, each

53 physical techniques, we show here that Aap B-repeat constructs assemble further into zinc-dependent f

54 These are: limiting interaction to a few repeated contacts akin to forming social bubbles; seekin

55 ures, ranging from solo LTRs to tandem dRemp repeats containing several internal LTRs, suggestive of

56 des a nucleotide-binding domain leucine-rich-repeat-containing (NLR) protein.

57 s cg03566881 located within the leucine-rich repeat-containing G-protein coupled receptor 6 (LGR6) (F

58 enin signaling in cells lacking leucine-rich repeat-containing G-protein coupled receptors (LGRs) 4,

59 Recently, we discovered that WD repeat-containing protein 5 (WDR5) binds to MYC and is a

60 em-resistant K. pneumoniae, resulting in the repeated convergence of virulence and carbapenem resista

61 om primary transcripts that contain tandemly repeated copies of the viral genome.

62 ive, protocol-based monitoring consisting of repeated coronary angiographies together with systematic

63 ial, with the length of new genes and tandem repeat corrections amounting to approximately 3.8% of th

64 nown disease-relevant STRs, normal ranges of repeat counts for most STRs in human populations are not

65 or become antibiotic-dependent, and require repeated courses or prolonged periods of antibiotic ther

66 red, regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) genes, a di

67 ered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology holds enormous potential for

68 ered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system and a transposon-disrupted

69 ered regularly interspaced short palindromic repeats (CRISPR).

70 ered regularly-interspaced short palindromic repeats/CRISPR-associated protein 9) to correct the GBE1

71 ho provided an anal swab sample as part of a repeated cross-sectional survey, VE against HPV-16/18 wa

72 s schlosseri regenerates the germline during repeated cycles of asexual reproduction.

73 w conditions, this formation and dissolution repeats cyclically.

74 duced hyperactivity on Days 4 to 7 after the repeated daily dosing of the drug.

75 Insertion of an ERV into an A-repeat deficient Xist rescues binding of Xist RNA to Spe

76 an those removed by FEN1, thereby leading to repeat deletion.

77 e precisely associated with the shape of CAG repeat dependence over time, among which 5 pairs with a

78 vectors and the spread of resistance through repeated deployment of insecticide treated nets (ITNs),

79 that functional MLH1 is required for the CAG repeat destabilizing effect of FAN1 loss.

80 The rate of SGF of repeat DMEK was higher than that of primary DMEK (P < .0

81 RNAs, cel-miR-71-5p and bma-lin-4, and O-150 repeat DNA were assessed.

82 xonal tension buffer by reversibly unfolding repeat domains of the spectrin tetramers to release exce

83 Intramammarily inoculation of repeated doses of 2.5 x 10(7) allogenic AT-MSCs did not

84 Severe anaphylaxis and/or the need for repeated doses of epinephrine to treat anaphylaxis are r

85 ata has evolved specific adaptation in the C-repeat/DREB binding factor (CBF)-dependent and CBF-indep

86 ric transcripts initiated from long terminal repeats during zygotic genome activation.

87 l times of sound waves that are generated by repeating earthquakes.

88 ed a bicistronic biosensor encoding distinct repeat epitopes in two open reading frames (ORFs), one t

89 Statistical analyses considering repeated events or event severity showed that ticagrelor

90 ippocampal place cells code for periodically repeating events and that the rate code can flexibly tra

91 a 46 h infusion of fluorouracil 2400 mg/m(2) repeated every 2 weeks (regimen one), or oxaliplatin 130

92 acupoints for 0.5 h at 7 days and thereafter repeated every 3 days for 6 times.

93 tabine 1000 mg/m(2) twice daily on days 1-14 repeated every 3 weeks (regimen two).

94 s from the same sequencing data, obfuscating repeated evolutionary patterns.

95 Such repeated evolutionary trajectories hold the potential to

96 lotype among this cohort suggests this novel repeat expansion configuration is a founder effect in th

97 The Fragile X-related disorders (FXDs) are Repeat Expansion Diseases, genetic disorders that result

98 otemporal dementia (FTD) is a hexanucleotide repeat expansion in C9orf72 (C9-HRE).

99 d neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene.

100 ohort for CANVAS and identified a novel RFC1 repeat expansion motif, (ACAGG)exp, in three affected in

101 s necessitate specific types of test such as repeat expansion testing.

102 ecedented opportunity to study mechanisms of repeat expansion, and a framework for evaluating the rol

103 GGGGCC hexanucleotide repeat expansions (HREs) in C9orf72 cause amyotrophic la

104 veal an etiological relationship between HTT repeat expansions and FTD/ALS syndromes and indicate tha

105 man-specific traits, and more than 40 tandem repeat expansions are known to cause neurological diseas

106 RNA repeat expansions are responsible for more than 30 incur

107 Repeat expansions are responsible for over 40 monogenic

108 Disease-associated repeat expansions in other TFs (HOXA13, RUNX2, and TBP)

109 disease is often seen in SCA2, and ATXN2 CAG repeat expansions in the long normal range increase ALS

110 cluding nine recently reported non-reference repeat expansions not discoverable via existing methods.

111 c disorders, and undoubtedly more pathogenic repeat expansions remain to be discovered.

112 enetic screening of FTD/ALS patients for HTT repeat expansions should be considered.

113 id not develop resistance to auranofin after repeated exposure for two weeks via a multi-step resista

114 Here we evaluate the effects of repeated exposure to Delta9-tetrahydrocannabinol (THC) i

115 working memory impairment and is specific to repeated exposure to multiple stressors.

116 cognitive impairment.SIGNIFICANCE STATEMENT Repeated exposure to stress profoundly impairs cognitive

117 This was repeated five times with intervals of 3-4 days between U

118 This method was repeated for a second larger set to build prediction and

119 and just one of these four is known to emit repeating FRBs(9).

120 ubes, storage-time, storage-temperature, and repeated freeze-thaw cycles on circulating BDNF concentr

121 e metagenome-assembled genomes often exclude repeated genomic elements, such as mobile genetic elemen

122 au, our findings support the hypothesis that repeated glacial and landslide damming in this region in

123 efinition: 1) infected children had positive repeat HCV-RNA testing or positive anti-HCV at age >=24

124 ctors of 1-year mortality after incident and repeated HFHs, respectively.

125 lished a clinical and technical protocol for repeated home collection of blood in patients with rheum

126 The alpha has high interspecific repeat homogeneity and was mapped to the centromeres of

127 , presence of preexisting comorbidities, and repeat ICU admission.

128 enerative disorder caused by an expanded CAG repeat in the HTT gene.

129 We demonstrate here the activity of these repeats in heterochromatin formation and maintenance.

130 We assessed 9 SNP and cytosine-adenine (CA) repeats in IFNG by nucleotide sequencing in 647 patients

131 genetic cause, which is an expansion of CAG repeats in the coding region of the causative genes that

132 t the formation of template induced 1-1 diad repeats in the polymer main chain shedding unique light

133 large expansions of 41 out of 44 pathogenic repeats, including nine recently reported non-reference

134 Sig-1R knockout exacerbates, the (G4C2)-RNA repeats-induced aberrant cytoplasmic accumulation of Ran

135 Here, we show that the microcephalin 1/BRCT-repeats inhibitor of hTERT (MCPH1/BRIT1) protein, mutate

136 Repeated injection of HoxB8 progenitors also allowed us

137 e treatment and to recognize any conceivable repeating injuries.

138 Repeat instability emerges first, followed by larger abe

139 dicator would be revealed by its response to repeated interrogation with a laser system, enabling the

140 us consisting of short, repeated sequences ('repeats') interspersed with short, variable sequences ('

141 Seven eyes (10.6%) required repeat intervention for IOP control with median time of

142 Following repeated intrarectal marginal-dose challenges with SIVma

143 In fission yeast, the inverted repeats IR-L and IR-R function as boundary elements at t

144 nging from 3.1 to 742 kb flanked by inverted repeats (IRs) up to 134 kb long.

145 polymerase zeta, and polymerase slippage at repeat junctions - on the generation of MNVs.

146 urgery are associated with increased risk of repeated keratoplasty.

147 derive by combining the multiple patterns of repeated kicking, on the one hand, with synergies result

148 Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of lat

149 ered regularly interspaced short palindromic repeats) knockouts of individual 15q13.3 microdeletion g

150 progressive loss of central vein access, and repeated life-threatening central venous catheter-associ

151 they describe how long interspersed nuclear repeat (LINE1) transcripts are recruited together with a

152 Many of the tandem repeat loci that we detected correlated with cytogenetic

153 We identified rapid and repeated loss of olfactory capacities synchronously asso

154 Plant nucleotide-binding (NB) leucine-rich repeat (LRR) receptor (NLR) proteins function as intrace

155 ::GUS transgenic plants for all leucine-rich repeat (LRR)-RLKs in Arabidopsis and analyzed their expr

156 test for cognitive flexibility dependent on repeated LTP.

157 ructural discovery of complete long terminal repeat (LTR) retroelements, which are widespread in euka

158 oring active versus restricted long terminal repeats (LTRs) revealed that the gene expression pattern

159 nd fine movements progressively changed with repeated manipulations.

160 We show that repeated mating reduced the sperm pool and increased the

161 precedented structural plasticity of helical repeats may be a general regulatory mechanism of HEAT-re

162 Repeated MCAM administration decreased fentanyl self-adm

163 or white) and CSF cryptococcal antigen or by repeat ME panel testing.

164 urements in a prospective cohort study using repeated measurements and physical examinations of 11652

165 Using a repeated measures design, we exposed small colonies of i

166 Most of differences between repeated measures did not exceed 0.5 mm (82% of S and 10

167 n heifers (200 kg) were used in a factorial, repeated measures experiment with two treatments and two

168 We took repeated measures of oculomotor and ocular performance f

169 The dependency in the data due to repeated measures was accounted for by a random intercep

170 just for correlation between fellow eyes and repeated measures within eyes.

171 in linear mixed-effects models adjusted for repeated measures, experimental variables, age, and inte

172 e complex designs, such as designs involving repeated measures.

173 istors with stable switching behaviors after repeated mechanical bending as well as organic synapses

174 , a class of ncRNAs of the B2 family of SINE repeats, mediate through their processing the transcript

175 POE targeted replacement (TR) mice following repeated mild TBI (rmTBI) using a lateral fluid percussi

176 n y ago due to a mammalian-wide interspersed repeat (MIR) transposition into the 5' leader sequence o

177 The d(CGA) triplet repeat motif is structurally dynamic and can transition

178 disorder-to-order transition of the ankyrin repeat motifs in the substrate binding domain of cpSRP43

179 ng limited ability to sequence homopolymers, repeated motifs or long-range structural variation, and

180 follow-up assessment of the same muscle with repeat MRI and muscle biopsy.

181 Here we examined the effect of exposure to repeated multiple concurrent stressors (RMS) on the conn

182 for CO(2) methanation as the process can be repeated multiple times.

183 Like other integration hubs, it contains repeated neurochemical motifs with distinct inputs: GABA

184 ohormone and nucleotide-binding-leucine-rich-repeat (NLR) networks, to regulate immunity pathways aga

185 In organotypic slice cultures, repeated NPY treatment reduces the complexity of the den

186 nt differences between individual CAFOs with repeat observations were also observed for both CH(4) an

187 Repeated observations for the same individuals allow dis

188 Understanding how transcription of these repeats occurs has implications for therapeutics in mult

189 The repeated OCTA acquisitions were used to assess the test-

190 We found that repeated odorant sampling differentially affected respon

191 rrogate how the differentially spliced alpha repeat of the PGANT9A and PGANT9B O-glycosyltransferases

192 y of using RepeatHMM-DB, we evaluate the CAG repeats of ATXN3 for 20 patients with spinocerebellar at

193 nds of chromosomes frequently contain tandem repeats of guanine nucleotides that can form stacked str

194 tes, the presence of nearly perfect inverted repeats of ~100 bp near the 5' end of vlsE, and an excee

195 The fact that TR-1 repeats often co-occur with knob180 repeats suggests tha

196 the rate of somatic expansion of the HTT CAG repeat or altering the resulting CAG threshold length-tr

197 o assess the reliability of the findings and repeat or build upon the work of other researchers.

198 egulation of nucleotide-binding leucine rich repeat or Nod-Like Receptor (NLR) genes as an important

199 Deletion of the entire IR-R repeat or, to a lesser degree, deletion of just the B bo

200 ning of a nonselective cation channel; while repeated or prolonged exposure induces formation of a tr

201 ding of gene content, isoform diversity, and repeat organization.

202 ated stress-exposed mice with imipramine and repeated our multi-OMIC analyses.

203 r, (iii) Zn uptake by lettuce increased with repeated OW applications, and (iv) no radical change in

204 ve patients were prospectively enrolled, and repeated peripheral blood collections were performed.

205 stionnaire administered at enrollment and at repeated phone interviews in the period 22 th April to A

206 In plants, it is not clear if palindromic repeats play a role in maintaining sequence conservation

207 fications are modulated by pentatricopeptide repeat (PPR) Kinetoplast Polyadenylation Factors (KPAFs)

208 We estimated associations of repeated pre- and postnatal serum PFAS concentrations wi

209 eralized estimating equations to account for repeat pregnancies and adjusting for potential confounde

210 e argue that this DLP sequence was caused by repeated pressurization of volatiles exsolved through cr

211 il, nucleotide-binding site and leucine-rich repeat protein (CNL).

212 tes to eight nucleotide-binding leucine-rich repeat protein (NLR)-encoding genes.

213 nome-derived nucleotide-binding leucine-rich repeat protein repertoire involved in disease resistance

214 d to the production of aggregating dipeptide repeat proteins (DPRs) via repeat associated non-AUG (RA

215 ay be a general regulatory mechanism of HEAT-repeat proteins.

216 solid food introduction were collected using repeated questionnaires at 1, 3, 6, 9 and 12 months.

217 essing either of two arginine-rich dipeptide repeats (R-DPRs), poly(GR) and poly(PR).

218 13 well-known repeats show that the inferred repeat ranges provide good estimation to repeat ranges r

219 red repeat ranges provide good estimation to repeat ranges reported in literature from population-sca

220 Plants use leucine-rich repeat receptor kinases (LRR-RKs) to sense sequence dive

221 In embryophytes, the leucine-rich repeat receptor-like kinases (LRR-RLKs) are signal recep

222 We found that the armadillo-repeat region 6 to 9 (ARM6-9) of KAP3, required for its

223 erally elicited by RTS,S to the central NANP repeat region of CSP.

224 y lysine residues in the microtubule-binding repeat region of tau.

225 sion protein, contains the archetypal heptad repeat regions 1 (HR1) and 2 (HR2).

226 the corresponding genes contain long tandem repeat regions.

227 S)3-responsive genes were located in the MDV repeat regions.

228 e made substantial corrections within tandem repeat regions.

229 esults reveal a mechanism by which satellite repeats regulate global gene expression in trans via piR

230 (HR 2.99 [95% CI 1.66-5.39]; p=0.0002); and repeat revascularisation was estimated in 17% after PCI

231 Repeat revascularization was more frequent with FFR-guid

232 ical validation within the workflow included repeated runs of stochastic steps and cell subsampling.

233 This exoskeleton is composed of repeating saccharides covalently cross-linked by peptide

234 In participants with repeated samples, the median decrease in fluoroether lev

235 ed in detail only in animal models, in which repeated sampling and tissue collection is possible.

236 imaging of cells in the organ chips and the repeated sampling of both the vascular and interstitial

237 ootstrap of children to adjust estimates for repeated sampling.

238 epresentations that were more distinct after repeated sampling.

239 main of Aedes aegypti Nbr adopts a HEAT-like repeat scaffold with basic patches constituting an RNA-b

240 Despite modest sensitivity, low-cost, repeat screening of the entire population could be cost-

241 The CDR was higher for repeat screening with DBT+SM than for the control group

242 P < .01) and was not significantly lower for repeat screening with FFDM (3.5 per 1000 women screened

243 The TCRalphabeta-Jurkat libraries enabled repeated screening and panning for antigen-reactive TCRs

244 Here, we investigated whether repeated scruff restraint, intraperitoneal (IP) injectio

245 persistent alteration of eCB signaling after repeated seizures may contribute to the development of e

246 paired using multiple distinct long inverted repeat sequences.

247 array, a genomic locus consisting of short, repeated sequences ('repeats') interspersed with short,

248 Average word error rates across a held-out repeat set are as low as 3%.

249 Evaluation on 13 well-known repeats show that the inferred repeat ranges provide goo

250 was greater after initial SLT compared with repeat SLT (mean difference, 1.0 mmHg; 95% CI, 0.2-1.8 m

251 We describe how repeat soil surveys are used to estimate changes in SOC

252 had been reported in Sprague-Dawley rats and repeated some of the above measures in that strain.

253 %) patients indicated willingness to undergo repeat SRFA with little to no fear in 292 (80.7%) patien

254 5-2.06, and 6.05 between the simple sequence repeat (SSR) markers umc1165-bnlg1017, umc1065-umc1637,

255 Trondelag region of Norway participated with repeated standardized body mass index (BMI) measurements

256 than distal inputs and fail to depress with repeated stimulation.

257 to the start of head movement decreased with repeated stimuli and this effect generalized to other st

258 Structural variants (SVs) and short tandem repeats (STRs) comprise a broad group of diverse DNA var

259 We performed repeated structural and functional brain MRI in 108 Barc

260 ive grammar generating sequences following a repeat structure (e.g., AB | AB, ABC | ABC), the latter

261 hat TR-1 repeats often co-occur with knob180 repeats suggests that the current role of the TRKIN/TR-1

262 y, approximately 20% of BCS patients require repeat surgery due to inadequate margins at the initial

263 the patients in the surgery group underwent repeat surgery.

264 simple power-law model for the frequency of repeat syntheses and assess the validity of this model u

265 prised of three potential GalNAc recognition repeats termed alpha, beta, and gamma.

266 Repeat testing 3-4 weeks later at four shelters document

267 he conversion rate (negative to positive) on repeat testing was one percent.

268 structural variant classes and short tandem repeats that are associated with gene expression and hum

269 g sequence bias in major and minor satellite repeats that is consistent with DNMT3A and DNMT3B specif

270 rm an auditory task where the probability to repeat the previous stimulus category is varied in trial

271 hort-lived migrants are known or believed to repeat the same migratory patterns throughout their live

272 A second observer repeated the measurements.

273 We repeated these analyses by type of immunocompromising co

274 maximum and minimum aortic area measurements repeated three times by three readers at three aortic le

275 If repeated today, such rapid mass loss to the ocean would

276 We first show that in response to repeated tones pyramidal (Pyr) neurons in male mouse aud

277 nt neurons, CGG RAN-blocking ASOs suppressed repeat toxicity and prolonged survival.

278 s well as a domain rich in tetratricopeptide repeats (TPRs).

279 rNMPs, including sites within trinucleotide-repeat tracts.

280 Over a period of repeated training sessions, mice received either paired

281 is suggested with respect to laser power and repeat treatments.

282 ase (Bhmt) mRNA and protein levels following repeated treatments were greater at 28 days compared to

283 However, repeated treatments with alpha-galactosylceramide, the p

284 sidual disease (MRD), leading to relapse and repeated treatments.

285 DNA trinucleotide repeats (TRs) can exhibit dynamic expansions by integer

286 If this result holds up and can be repeated under nonsterile conditions and with a broader

287 lusively of arginine-aspartic acid dipeptide repeats undergo length-dependent condensation and speckl

288 The large size of the repeat unit in this VNTR, along with our multiplexed seq

289 n assigned atomic mobility value within each repeat unit.

290 ce (mm) between surface reconstructions from repeated US was [Formula: see text] and from US and CT w

291 Tissue morphogenesis relies on repeated use of dynamic behaviors at the levels of intra

292 nse to an addictive substance can facilitate repeated use: That is, individuals experiencing more pos

293 res and were both associated with a need for repeat valve replacement.

294 South African guidelines recommend repeat viral load testing within 6 months when human imm

295 ly 32 forward, 34 tandem, and 17 palindromic repeats were detected.

296 s of delta revealed novel pentameric folding repeats, which we term beta-bracelets, in the intermedia

297 Each scenario was then repeated while reading a 2-minute script, simulating a t

298 s often associated with LC and disorder, but repeats, while compositionally biased, might also induce

299 Ts performed on nasopharyngeal specimens and repeated within 90 days after initial testing were analy

300 2 and NR2C2, can bind to (TCAGGG)(n) variant repeats within telomeres and it has been proposed that t