ライフサイエンスコーパス: replacement

1 jacent Borcs7 gene was humanized by syntenic replacement.

2 ng transplant via transcatheter aortic valve replacement.

3 of the risks associated with surgical valve replacement.

4 assigned to undergo either TAVR or surgical replacement.

5 m for which the main treatment remains joint replacement.

6 pace width, 3D joint shape, and future joint replacement.

7 transfusion after transcatheter aortic valve replacement.

8 iated with risk of aortic valve stenosis and replacement.

9 the nearest traditional PCI patient without replacement.

10 endently associated with repeat mitral valve replacement.

11 ant 56 days after transcatheter aortic valve replacement.

12 f factor VIII (FVIII), is treated by protein replacement.

13 ivalent) at most recent follow-up after lens replacement.

14 ailable treatment strategy is surgical valve replacement.

15 rates vary in both pattern and type of tooth replacement.

16 FFR for coronary evaluation pre-aortic valve replacement.

17 diversification potential using bioisosteric replacement.

18 he same emm type had an identical amino acid replacement.

19 tion required elective surgical mitral valve replacement.

20 sorption and requires oral pancreatic enzyme replacement.

21 both associated with a need for repeat valve replacement.

22 tients undergoing transcatheter aortic valve replacement.

23 nufacturing and adoption of tissue and organ replacements.

24 There were 47 primary end points (41 valve replacement, 1 death, and 5 hospitalizations-1 chest pai

25 th BPVT had a higher probability of valve re-replacement (68% vs. 24% at 10 years' post-BPVT; log-ran

26 Aegean; and there was large-scale population replacement after the Bronze Age.

27 ications to the trifluoroethoxy bioisosteric replacement allowed rebalancing of properties, such as l

28 insect vectors, and population modification (replacement/alteration) approaches, which interfere with

29 envisioned to aid the development of protein replacement and gene correction therapeutics in targeted

30 Preclinical advances in cell-based, protein replacement and gene therapies are paving the way for cl

31 All survivors were off immunoglobulin replacement and had protective vaccine responses to teta

32 Current treatment includes immunoglobulin replacement and immunosuppressive agents.

33 -deep sequencing analysis, and to serve as a replacement and improvement over previous suffix-array b

34 njury early after transcatheter aortic valve replacement and is an independent predictor of 30-day mo

35 Substitution site-specific replacement and network analysis revealed that chemicall

36 f a complete PEG rupture with the succeeding replacement and recovery of the fractured segments conse

37 ay have implications for the timing of valve replacement and the role of adjunctive medical therapy a

38 ransform medical device manufacturing, organ replacement, and the treatment of diseases and physiolog

39 cal therapy, surgical mitral valve repair or replacement, and, in the setting of advanced heart failu

40 Using a molecular replacement approach in mouse hippocampal neurons, we sh

41 We herein report an enzyme replacement approach to treat PA using a combination of

42 for transfemoral transcatheter aortic valve replacement as agreed by the heart team were randomly as

43 tients undergoing transcatheter aortic valve replacement at 445 hospitals were analyzed.

44 ead minnows were cage deployed pre- and post-replacement at sites with varying proximities to the WWT

45 PqqE variants with nondestructive ligand replacements at AuxII also show that the reduction poten

46 ples were collected bimonthly, pre- and post-replacement, at 11 sites along the Colorado River upstre

47 arkinson disease features that dopamine cell replacement based on generating neurons from human pluri

48 tools that provide a mechanism for incumbent-replacement between species filling similar ecological r

49 A handful of novel drop-in replacement biofuels for conventional transportation fue

50 herapeutic strategy is proposed, where blood replacement (BR) robustly reduces infarctions and improv

51 183 were forecasted to have a TFR lower than replacement by 2100.

52 iscrete transcriptome subtypes for HGSOC and replacement by a more realistic model of continuous tumo

53 Thus, metastable oligomers antagonize their replacement by amyloid fibrils both by competing for mon

54 reus, yet they have a limited life span with replacement by bone marrow derived monocytes.

55 The results indicated that FO replacement by dietary AM did not change the levels of m

56 Degradation of damaged D1 and its replacement by nascent D1 are at the heart of a PSII rep

57 verall carriage rates remain stable owing to replacement by non-PCV serotypes.

58 vaccine serotypes (VT) has declined, partial replacement by non-vaccine serotypes (NVT) was observed

59 ead seabream offspring through fish oil (FO) replacement by vegetable oils (VO) in the broodstock die

60 severely impacted aortic valves that require replacement, catheter-based bioprosthetic valve deployme

61 However, the galvanic replacement chemistry of alkali metals has rarely been e

62 monly reported in transcatheter aortic valve replacement clinical trials.

63 s is exploited to identify suitable cysteine replacements compatible with protein activity and stabil

64 luoropropylene oxide-dimer acid (HFPO-DA), a replacement compound for perfluorooctanoic acid (PFOA),

65 We applied scaffold hopping and bioisosteric replacement concepts to eliminate unwanted structural mo

66 m, clinically used valve-sparing aortic root replacement conduit configurations have comparable hemod

67 nwich Bay, Connecticut, was valued using the replacement cost methodology and allocated by municipal

68 lative to baseline trends, the odds of valve replacement decreased by 4.0% per quarter (odds ratio [O

69 ng of the mechanisms involved in this tissue replacement, development and pathology.

70 Whether VD replacement during and after DAA therapy can improve hep

71 ht percent of FMT-driven changes were strain replacements, emphasizing the importance of detailed pro

72 The replacement feature selected can be identical for all re

73 of late gadolinium enhancement suggestive of replacement fibrosis or focal necrosis.

74 ac morphology and function, left ventricular replacement fibrosis, and pre-post contrast T1 mapping t

75 y and long-term costs associated with device replacement, follow-up, and healthcare utilization were

76 nd the PV is usually the site for prosthetic replacement following a Ross operation.

77 corporating oleogels into cookies as a fully replacement for commercial shortenings.

78 on-toxic, and should find broad utility as a replacement for diazomethane.

79 Valve repair is preferable over replacement for rheumatic mitral regurgitation but is no

80 risk of reaching a clinical end point (valve replacement for symptoms, hospitalization, or cardiovasc

81 uthentication of cancer cell lines and not a replacement for the STR method.

82 agnosis, nutritional intervention and enzyme replacement for these infants, allowing most infants wit

83 ended to vinyl heterocycles meant to provide replacements for the irreversible reactive "warheads" of

84 studies in the near term, and in some cases replacements for them in the longer term.

85 tients undergoing transcatheter aortic valve replacement from November 1, 2011 to June 30, 2016.

86 he biofabrication of large- and small-vessel replacements, functional microvasculature has been parti

87 segment (D290V) of hnRNPA2 suggests that the replacement fundamentally alters the fibril structure to

88 iggyback group (40.3%) compared to the caval replacement group (51.8%, P < 0.001).

89 maintains cell fate while, in contrast, the replacement H3.3 variant opposes cell differentiation du

90 nd balance after supporting cells regenerate replacement hair cells.

91 end points after transcatheter aortic valve replacement has been conducted to date.

92 Antithrombin (AT) replacement has been suggested to prevent venous thrombo

93 Surgical valve repair or replacement has been the standard of care for patients w

94 edic or abdominal surgery including hip/knee replacement, hepatobiliary, colorectal, gynecology oncol

95 ts support the hypothesis of an active clade replacement, implying that direct competition with angio

96 every year, exceeding surgical aortic valve replacement in 2019 (72,991 vs. 57,626), and it is now p

97 wed low endocardial voltages and fibro-fatty replacement in areas of late gadolinium enhancement pres

98 ials (Surgical or Transcatheter Aortic Valve Replacement in Intermediate-Risk Patients) to 100% Medic

99 ial fibrillation; transcatheter aortic valve replacement in patients with symptomatic severe aortic v

100 g as an alternative to surgical mitral valve replacement in selected high-risk patients.

101 tients undergoing transcatheter aortic valve replacement in the US, vascular complications and in-hos

102 lve replacement versus surgical aortic valve replacement in the whole cohort and within each flow-gra

103 y all analyzed strains had single amino acid replacements in penicillin-binding protein 2X (PBP2X), a

104 thodological innovations, including subphase replacement, in situ Langmuir-Blodgett transfer, and rea

105 Before the WWTP replacement, in vitro ER (24 ng 17beta-estradiol equival

106 ations that have plagued traditional hormone replacement interventions.

107 Although aortic valve replacement is associated with a major benefit in high-g

108 We propose that this replacement is linked to the transition from two ancestr

109 were changes in biomedical (Rotterdam Renal Replacement Knowledge Test living donation subscale, R3K

110 G), lung resection, or lower extremity joint replacement (LEJR) were identified in the 2016-2017 Medi

111 were forecasted to have a TFR lower than the replacement level (TFR <2.1), and 183 were forecasted to

112 A sustained TFR lower than the replacement level in many countries, including China and

113 he suitability of polylactic acid (PLA) as a replacement material to PDMS for microfluidic cell cultu

114 pausal symptoms, in which testosterone (TES) replacement may play a potential role.

115 ngs, we propose that SinI utilizes a residue replacement mechanism to block SinR multimerization, res

116 esults show that general and dynamic feature replacement methods achieve a higher performance than cl

117 understand dynamics of the residual VTs and replacement NVT serotypes post-PCV.

118 Herein, we report that the replacement of a methylene unit of the adamantane group

119 ation typically dominates over the selective replacement of a single C-F bond, hindering the developm

120 e, we disclose a photoredox protocol for the replacement of a single fluorine atom with hydrogen in e

121 Site-specific replacement of active-site amino acids revealed the pres

122 Replacement of Arg-177 in PKG1alpha with alanine or meth

123 The selective replacement of C-H bonds in complex molecules, especiall

124 established that there was a displacement or replacement of cytoplasmic gross cystic disease fluid pr

125 e remodeling is essential for the repair and replacement of damaged and old bone.

126 pplications such as the precise insertion or replacement of DNA fragments that contain the coding reg

127 Thus, replacement of either Leu-395 or Phe-396 with Ala led to

128 twork structure changed significantly as the replacement of forbs by grasses resulted in changes in r

129 concentrations were beneficially affected by replacement of fructose with glucose.

130 Although replacement of H2A with the evolutionarily conserved H2A

131 fusion (pre-F) conformation, with or without replacement of its transmembrane and cytoplasmic tail do

132 Remarkably, replacement of Leu in 1 and in derivatives of 1 by Trp t

133 ould be increased by more than 200-fold upon replacement of liposomes with bacteriophage Qbeta virus-

134 among the analyzed virus strains, except for replacement of lysine with arginine at 378th position of

135 ific therapies, can be prevented by targeted replacement of mitochondrial creatine kinase or mitochon

136 which this situation results from functional replacement of native by foreign genes, functional mitoc

137 disorders of the CNS.SIGNIFICANCE STATEMENT Replacement of oligodendroglia and myelin regeneration h

138 ion-coupled histone H3 turnover, driving the replacement of resident H3 nucleosomes with CENP-A(Cnp1)

139 Taste bud maintenance depends on continuous replacement of senescent taste cells with new ones gener

140 ed us to identify the gain, loss, and strain replacement of specific species and link these events to

141 old of the novel AR inhibitor cemtirestat by replacement of sulfur with oxygen.

142 Here, we report the successful replacement of tetrathiafulvalene (TTF) with a nickel gl

143 and registry the outcomes after aortic valve replacement of the 4 flow-gradient groups.

144 The replacement of the Al- by an Fe atom leads to a planar b

145 Self-replacement of the dominant tree species was only preval

146 homology-directed repair (HDR), resulting in replacement of the excised region with a donor template

147 Hemiarthroplasty (prosthetic replacement of the femoral head) fixation via bony growt

148 a 3D-printed nasopharyngeal (3DP) swab as a replacement of the FLNP swab.

149 coli strains were evolved in parallel after replacement of the genes pgi or tpiA with orthologous DN

150 We previously found that replacement of the human-origin PA gene segment in avian

151 Replacement of the native sequence downstream of a gene

152 Replacement of the single biotin by the biotin-Si-NPs bo

153 In agreement, pausing was lost upon replacement of the TFIID complex with TATA-binding prote

154 Replacement of V(D)J recombinase targets at two differen

155 Our findings reveal that replacement of XEN cells with ESCs transiently expressin

156 omologues may diverge evolutionarily through replacement of, rather than tinkering with, their ancest

157 ey have found particular use as bioisosteric replacements of several heteroatomic functional groups,

158 ons, large deletions, targeted insertions or replacements of short sequences, and precise base change

159 Here, we show that replacements of the positively-charged residues that con

160 indane bicyclic system followed by thiazole replacement on sulfonamide led to identification of lead

161 open questions about the effect of dopamine replacement on the prioritization of memories by reward

162 s deciphering the effect of functional group replacements on Gibbs binding energies DeltaG.

163 understanding the dispersal process and the replacement or assimilation of indigenous human populati

164 S onset and progression and propose that ANG replacement or stabilization would benefit pre-symptomat

165 additional patients underwent surgical valve replacement or valve-in-valve TPVR.

166 ness evidence about strategies such as fluid replacement, oxygen, glucocorticosteroids, methylxanthin

167 ry artery bypass surgery; heart valve repair/replacement; percutaneous coronary intervention; or hear

168 pared with only one metric related to kidney replacement planning and two related to patient-reported

169 fter transfemoral transcatheter aortic valve replacement; propensity score-matching identified pairs

170 te the good clinical outcomes of total joint replacements, prosthetic joint infections still remain a

171 experiments, we demonstrate that a galvanic replacement reaction (GRR) between the Ga seeds and a co

172 These dopamine (DA) replacement-resistant symptoms are associated with losse

173 al risk ratios for aortic valve stenosis and replacement, respectively, of 1.52 (95% CI: 1.23 to 1.87

174 Transformation-mediated gene replacement resulted in two putative CpRbp1-null mutants

175 We have developed a new class of FVIII replacement, rFVIIIFc-VWF-XTEN (BIVV001), that is physic

176 and may be superior to surgical aortic valve replacement (SAVR) for mortality, stroke, and rehospital

177 sonable alternative to surgical aortic valve replacement (SAVR) for patients with severe aortic steno

178 aortic stenosis after surgical aortic valve replacement (SAVR) or transcatheter aortic valve replace

179 cement (TAVR) and redo surgical aortic valve replacement (SAVR) represent the 2 treatments for aortic

180 lacement [TAVR] versus surgical aortic valve replacement [SAVR]) using trial-adjudicated outcomes ver

181 ently shown to remain stable post-PCV due to replacement serotypes, there was no change in diversity

182 linically used for valve-sparing aortic root replacement, some specifically focused on recapitulating

183 We utilized a molecular replacement strategy in which exogenous SV2A was express

184 cedures of the hindfoot; and the design of a replacement subtalar joint prosthesis.

185 are a serious adverse event following joint replacement surgeries; antibiotics are usually added to

186 ve-in-valve (VIV) transcatheter aortic valve replacement (TAVR) and redo surgical aortic valve replac

187 evice (LVAD), and transcatheter aortic valve replacement (TAVR) are expensive cardiovascular technolo

188 the pivotal evaluations of transcatheter AV replacement (TAVR) devices.

189 isturbances after transcatheter aortic valve replacement (TAVR) has been elusive.

190 Transcatheter aortic valve replacement (TAVR) has emerged as a reasonable alternati

191 The role of transcatheter aortic valve replacement (TAVR) in this high-risk population is debat

192 sults showed that transcatheter aortic valve replacement (TAVR) is noninferior and may be superior to

193 e phenomena after transcatheter aortic-valve replacement (TAVR) is not known.

194 olic events after transcatheter aortic-valve replacement (TAVR) is unclear.

195 The effect of transcatheter aortic valve replacement (TAVR) on kidney function stage in patients

196 and 1 year after transcatheter aortic valve replacement (TAVR) or surgery.

197 Two competing transcatheter aortic valve replacement (TAVR) technologies are currently available.

198 he indication for transcatheter aortic valve replacement (TAVR) to low-risk patients with symptomatic

199 Transcatheter aortic valve replacement (TAVR) use is increasing in patients with lo

200 enosis undergoing transcatheter aortic valve replacement (TAVR).

201 acement (SAVR) or transcatheter aortic valve replacement (TAVR).

202 on is common post-transcatheter aortic valve replacement (TAVR).

203 xplantation after transcatheter aortic valve replacement (TAVR).

204 condary access in transcatheter aortic valve replacement (TAVR).

205 ts in futility of transcatheter aortic valve replacement (TAVR).

206 ct patients after transcatheter aortic valve replacement (TAVR).

207 ions 1 year after transcatheter aortic valve replacement (TAVR).

208 eatment arms (eg, transcatheter aortic valve replacement [TAVR] versus surgical aortic valve replacem

209 cava preserving piggyback technique or caval replacement technique without veno-venous bypass or shun

210 rve, >0.9), indicating a potential role as a replacement test for biopsy in selected patients.

211 ficiently accurate, MRI may play a role as a replacement test for biopsy.

212 The replacement texture of olivine is unambiguous evidence o

213 Cell-replacement therapies have long been an attractive prosp

214 Cell replacement therapies hold great therapeutic potential.

215 biology have allowed the development of cell-replacement therapies that comprise dopamine neurons der

216 ly, self-regulated insulin delivery and cell replacement therapies, hydrogels are employed to mitigat

217 ights toward the development of future tooth replacement therapies.

218 of mechanical ventilation (23.2%) and renal replacement therapy (6.6%) but the lowest rates of remde

219 o, 1.01; 95% CI, 1.00-1.03; p = 0.02), renal replacement therapy (adjusted odds ratio, 1.81; 95% CI,

220 umatic and non-traumatic AKI requiring renal replacement therapy (AKI-RRT).

221 Ls) and brain infarctions and whether enzyme replacement therapy (ERT) changes this risk.

222 Enzyme replacement therapy (ERT) is a standard therapeutic opti

223 diovascular events, and initiation of kidney replacement therapy (KRT).

224 interventions are not recommended: oestrogen replacement therapy (Level A2) and acetylcholinesterase

225 risk group were more likely to require renal replacement therapy (odds ratio, 10.4; 95% CI, 5.9-18.1)

226 of HUS (primary outcome) and need for renal replacement therapy (RRT) (secondary outcome) in STEC-in

227 independent predictor of the need for renal replacement therapy (RRT) in the first month post-LT.

228 AKI, or on the need for postoperative renal replacement therapy after adjustments for confounders.

229 risk for falls do not benefit from dopamine replacement therapy and often result in long-term hospit

230 ltration (UF(NET))) during continuous kidney replacement therapy are associated with increased mortal

231 g] vs 28% [placebo]) and 1 trial of nicotine replacement therapy at 12 months (n = 257; 8.1% vs 8.2%)

232 vely associated with the initiation of renal replacement therapy at admission.

233 epted surgical technique for subretinal gene replacement therapy delivery in pediatric patients exist

234 A regimen of intermittent enzyme replacement therapy dosing with rhbeta-Gal, followed by

235 process could serve as an effective protein replacement therapy for LAMA2-CMD.

236 aminin-111 can serve as an effective protein-replacement therapy for LAMA2-CMD.

237 It is still a challenge to develop gene replacement therapy for retinal disorders caused by muta

238 gene editing and messenger RNA-based protein replacement therapy hold tremendous potential to effecti

239 s first-line treatment for continuous kidney replacement therapy in critically ill patients, the evid

240 bout the cognitive effects of early dopamine-replacement therapy in neurological disorders.

241 risk of acute kidney injury requiring renal replacement therapy in SOT vs. non-SOT patients (37% vs.

242 ngs do not support the use of HES for volume replacement therapy in such patients.

243 These findings suggest that continuous renal replacement therapy initiated early and continued or lon

244 Continuous renal replacement therapy is associated with reduced ammonia c

245 sk of mortality is high, especially if renal replacement therapy is needed.

246 Enzyme replacement therapy is one therapeutic option, but since

247 Acute kidney injury requiring renal replacement therapy occurred in 20% of SOTr compared to

248 X chromosome genomic imprinting and hormone replacement therapy on brain development.

249 ease modelling, and examining novel cellular replacement therapy strategies.

250 that could signal a new class of factor VIII replacement therapy with a weekly treatment interval.

251 ccurrence and optimize the outcomes of tooth replacement therapy with dental implants in this specifi

252 imic led to change in management (eg, enzyme replacement therapy) or family screening in all cases.

253 tilation, 81 (3.2%) were treated with kidney replacement therapy, and 553 (21%) died.

254 y of breast cancer, body mass index, hormone replacement therapy, and use of tobacco and alcohol.

255 by renal failure requiring continuous renal replacement therapy, hypertension (systolic blood pressu

256 ated in Parkinson's disease (PD) by dopamine replacement therapy, often with detrimental consequences

257 a composite of in-hospital mortality, renal replacement therapy, or severe right ventricular failure

258 at 7 days, the need for postoperative renal replacement therapy, postoperative red blood cell transf

259 e in ICU patients requiring continuous renal replacement therapy.

260 amylin, and holds promise as a dual-hormone replacement therapy.

261 ther their incidence is increased by hormone replacement therapy.

262 surgery without requiring pancreatic enzyme replacement therapy.

263 ributing to the development of an LPL enzyme replacement therapy.

264 ictive therapy and decisions regarding renal replacement therapy.

265 removal using ultrafiltration during kidney replacement therapy.

266 ill patients treated with continuous kidney replacement therapy.

267 severe symptomatic AS awaiting aortic valve replacement, there has been a trend of increasing wait t

268 Nearly 100,000 people underwent total hip replacement (THR) in the United Kingdom in 2018, and mos

269 ographs in patients who underwent total knee replacement (TKR) and matched control patients who did n

270 However, for autologous cell replacement to be effective, manufacturing strategies wi

271 To facilitate adoption of MNW networks as a replacement to ITO, they must overcome their inherent st

272 compound, we utilized sequential structural replacements to improve the potency (IC(50)), pharmacoki

273 Transcatheter pulmonary valve replacement (TPVR) is associated with a risk of procedur

274 n genetically engineered human APOE targeted replacement (TR) mice following repeated mild TBI (rmTBI

275 Regular immunoglobulin replacement treatment reduced the incidence of invasive

276 XLA, revealing that although immunoglobulin replacement treatment reduces the incidence of invasive

277 eys with urine recirculation (URC) and urine replacement (UR).

278 oing transfemoral transcatheter aortic valve replacement, use of CS compared with GA resulted in simi

279 ge aortic annuli, transcatheter aortic valve replacement using 29-mm Sapien-3 and 34-mm ER is safe an

280 Transcatheter mitral valve replacement using aortic transcatheter heart valves has

281 ences between individuals destined for joint replacement versus controls at regions of the joint that

282 al events between transcatheter aortic valve replacement versus surgical aortic valve replacement in

283 Replacement was also influenced by management intensity,

284 n (eg, transcatheter aortic and mitral valve replacements) was further elucidated in large-cohort out

285 Piggyback technique, compared with caval replacement, was associated with a reduced incidence of

286 lso occurred and multiple pathways of forest replacement were observed for some species.

287 which includes membrane repair, removal, and replacement, were detected in model systems of lysosomal

288 strate that embryonic ECM undergoes constant replacement, which is likely necessary to maintain netwo

289 s turn into conical teeth and undergo cyclic replacement, while those added labially achieve a stella

290 annuli underwent transcatheter aortic valve replacement with 29-mm Sapien-3 (n=640) or 34-mm ER (n=1

291 3.9 +/- 1.3% and 41.1 +/- 8.7% Pt following replacement with 4.1 and 1.6 nm diameter Au NPs, respect

292 ior tooth (premolar or molar) and subsequent replacement with a dental implant were recruited and ran

293 ganic structure-directing agent, whereas its replacement with an organic results in a nonclassical mo

294 Analogous to C(5)H replacement with N and to a much greater extent than dec

295 alpha1 subunit transmembrane domain and part-replacement with nonsense residues.

296 As) down-regulate MISTR1(NDUFA4) followed by replacement with paralogs MItochondrial STress Response

297 access method, to transcatheter aortic valve replacement with the first generation Portico valve and

298 a total of 22 876 referrals for aortic valve replacement, with (N=8098) TAVR and (N=14 778) SAVR refe

299 mental iron more tightly allow complete iron replacement within 15-60 min in one visit.

300 Our results show that this replacement yields very good results for a number of che