ライフサイエンスコーパス: replacement of

1 Replacement of 1 serving/d of yogurt with 1 serving/d of

2 for 5 wk every 4 mo for 3 y or to daily meal replacements of 1-2 meals for 3 y [regular (RE) group].

3 onance spectroscopy (MRS) resulting from the replacement of (1)H with (2)H.

4 In analyses modeling dietary substitutions, replacement of 100 kcal/d from red and processed meat wi

5 spark interest in this field and enable the replacement of (3)He counters by semiconductor-based neu

6 Replacement of 394 with alanine or restoration of the co

7 stem cells (MSCs) appeared to contribute in replacement of 40% and 13% host hepatocytes, respectivel

8 h Africa by ~2500 BCE and, by ~2000 BCE, the replacement of 40% of Iberia's ancestry and nearly 100%

9 The replacement of 75% of fat, for both types of mucilage, h

10 s9 strategy, in which two guide RNAs promote replacement of a candidate gene with a resistance gene;

11 Replacement of a conserved Lys residue with Ala abolishe

12 ) was analyzed, as well as the impact of the replacement of a conventional external nonpolar solvent

13 major challenge facing the discipline is the replacement of a generation of clinical microbiologists.

14 The ongoing efforts dedicated to the replacement of a lab-based detector by a cellphone with

15 Herein, we report that the replacement of a methylene unit of the adamantane group

16 Phosphorothioation (PT) involves the replacement of a nonbridging phosphate oxygen on the DNA

17 Replacement of a phenol, present in our previously repor

18 Through careful SAR, the successful replacement of a polar pyrazole group by a simple chloro

19 ation typically dominates over the selective replacement of a single C-F bond, hindering the developm

20 e of therapy, as in most cases, they require replacement of a single deficient hepatic enzyme, and mu

21 e, we disclose a photoredox protocol for the replacement of a single fluorine atom with hydrogen in e

22 Regiospecific replacement of a single phosphate (PO2) by a dithiophosp

23 e report a comprehensive study of systematic replacement of a single phosphate with an amide linkage

24 ed novel CF(3)-alkoxy groups as bioisosteric replacements of a fluorinated phenyl ring and properties

25 -low-dose oral anticoagulation, and even its replacement of acetylsalicylic acid in the presence of a

26 Site-specific replacement of active-site amino acids revealed the pres

27 f the obtained building blocks for isosteric replacement of alkyl-substituted isoxazole and pyrazole

28 wave at 60,000 years ago and the subsequent replacement of all indigenous populations, is in need of

29 to explore the impact of broadly distributed replacement of alpha-amino acid residues with beta-amino

30 siderable potential with special emphasis on replacement of amino acids.

31 cular nucleophilic aromatic substitution and replacement of an alkyl group by the nucleophilic alpha-

32 anisms leading to extracellular matrix (ECM) replacement of areas of glomerular capillaries in histol

33 Replacement of Arg-177 in PKG1alpha with alanine or meth

34 stal structure of human VPS33A predicts that replacement of arginine 498 by tryptophan will de-stabil

35 olding conformation triggered by the Glu-145 replacement of Asp.

36 Replacement of Asp506 and Asp571 for alanine residues ab

37 Partial replacement of barley malt by adjuncts is a common pract

38 gon secretion with somatostatin infusion and replacement of basal plasma insulin and glucagon concent

39 lacial cycles, likely causing rapid regional replacement of biota.

40 el in the early 20th century, the repair and replacement of blood vessels have been key to treating a

41 h their combined role in hydrophobic gating, replacement of both Leu residues with the isosteric but

42 Furthermore, replacement of both salt bridge partners in the ion-bind

43 or mitochondrial DNA phylogenies, indicating replacement of both the mitochondrial and Y chromosomal

44 This decline was mainly caused by the replacement of BPA by BPS in thermal paper and the lower

45 Remarkably, in a proto-HCN background, the replacement of breakpoint serine with a bulky hydrophobi

46 The selective replacement of C-H bonds in complex molecules, especiall

47 Thus, replacement of C-H by C-D raises the hydrogen atom abstr

48 n, treatment with spironolactone allowed for replacement of calcification by hyalinosis.

49 a public health approach has focused on the replacement of carbohydrates with unsaturated fats.

50 The replacement of carbon atoms at the zigzag periphery of a

51 Whether replacement of cisplatin with cetuximab-an antibody agai

52 perovskites can decrease by ca. 50 GPa upon replacement of Cl with Br.

53 protein turnover, which involves removal and replacement of claudins both in the steady state and dur

54 events were required to prevent disease, and replacement of Clostridia rescued obesity.

55 a robust new approach for acute removal and replacement of cMyBP-C in situ.

56 novel cut and paste approach for removal and replacement of cMyBP-C N'-terminal domains (C0-C7) in de

57 The (formal) replacement of Co in cobalamin (Cbl) by Ni(II) generates

58 lectrocatalysts and is very flexible for the replacement of cobalt by other transition metals.

59 ains unclear, however, and it is likely that replacement of colonized water reservoirs may be require

60 r this organelle can be achieved through the replacement of conventional N-alkylated pyridinium moiet

61 Metasurfaces have facilitated the replacement of conventional optical elements with ultrat

62 Degradable polymers are desirable for the replacement of conventional organic polymers that persis

63 The replacement of current petroleum-based plastics with sus

64 Surprisingly, in AOX1A, replacement of CysI by alanine, which cannot form a (thi

65 Replacement of cysteine 86 with a serine (VbrK C86S muta

66 This mutation, c.705G>C, causes replacement of cysteine at position 53 of the 191-amino-

67 established that there was a displacement or replacement of cytoplasmic gross cystic disease fluid pr

68 e remodeling is essential for the repair and replacement of damaged and old bone.

69 Epithelial tissues require the removal and replacement of damaged cells to sustain a functional bar

70 Sertoli cells often lead to infertility, but replacement of defective cells has been limited by the i

71 peutic strategy in treatment of ALS would be replacement of defective glia.

72 lls (hPSCs) are a promising resource for the replacement of degenerated ventral midbrain dopaminergic

73 driving events in neurodegenerative disease, replacement of degenerating cell populations, and compou

74 of improved esthetics, marked by the gradual replacement of dental amalgam with dental composite and

75 The main reason cited for the replacement of dental composite restorations is the recu

76 nd IHD mortality for theoretical, isocaloric replacement of dietary fatty acids (FAs) in quintiles (1

77 pplications such as the precise insertion or replacement of DNA fragments that contain the coding reg

78 taphylococcus epidermidis Importantly, while replacement of DNABII proteins within the NTHI biofilm m

79 nstrates their turnover kinetics and gradual replacement of donor-derived HSPCs from a circulating po

80 itive detection of dsDNA based on the strand replacement of dsDNA by peptide nucleic acid (PNA) and t

81 Due to the strand replacement of dsDNA by PNA, dsDNA can be directly detec

82 Replacement of each of four candidates for the proximal

83 Remarkably, double replacement of eArg-8 with Glu and of gGlu-83 with Lys r

84 Thus, replacement of either Leu-395 or Phe-396 with Ala led to

85 Phenylalanine replacement of either of these residues decreased aldola

86 BP1 SGs depended on G3BP1 RNA binding; thus, replacement of endogenous G3BP1 with the K376Q mutant or

87 Moreover, replacement of endogenous WT CEP131 with an S78D phospho

88 The replacement of ethambutol with moxifloxacin did not sign

89 ifference is significantly reduced by either replacement of extracellular Ca(2+) with Mg(2+) or the a

90 is is supported by further observations that replacement of extracellular Cl(-) with gluconate(-) dim

91 nerate free holes (p-type doping), while the replacement of Fe(2+) by Ga(3+) cations, taking place in

92 Replacement of fishmeal in feeds is critical for sustain

93 twork structure changed significantly as the replacement of forbs by grasses resulted in changes in r

94 symbiosis has a key role in accelerating the replacement of formerly dominant moss communities by vas

95 concentrations were beneficially affected by replacement of fructose with glucose.

96 of the brain this only leads to insufficient replacement of functionally important dopaminergic neuro

97 The latter suggests ongoing allelic replacement of functionally relevant amino acid variants

98 Replacement of G29 with A, D, F, K, M, and T, to differe

99 In contrast, replacement of G29 with P, a turn-prone residue with a s

100 In this study, we showed that while replacement of G29, a residue at the edge of the recepto

101 anced to early phase clinical trials for the replacement of G6Pase in GSD Ia and GAA in GSD II (Pompe

102 her insertion of exogenous DNA (knock-in) or replacement of genomic segments is very poor.

103 -glycine can serve as a reliable and general replacement of glycine in triple helical collagen.

104 nt starch and dietary fiber content with the replacement of green banana flour (up to a fivefold impr

105 that the thermodynamics can be optimized by replacement of H in the -OH group of cyclohexanol and ph

106 Theoretical calculations reveal that replacement of H with a metal leads to a reduction of th

107 Although replacement of H2A with the evolutionarily conserved H2A

108 Replacement of H2Q with the higher-potential EPTM, 2-chl

109 a major defect in CD4 binding induced by the replacement of H375 by a serine.

110 Replacement of Hg with non-toxic Au based catalysts for

111 t years, the food industry is working on the replacement of high energy methodologies with more susta

112 In contrast, any replacement of His(237), lining the metal exit route, lo

113 The strategic replacement of hydrogen with deuterium can affect both t

114 mosaic process of modern human dispersal and replacement of indigenous Neanderthal populations.

115 eins were observed, and illegal addition and replacement of ingredients were discovered, i.e. undecla

116 The replacement of inorganic semiconductors with molecule-ba

117 inal sections in 10-week-old dKO mice showed replacement of intervertebral disk structures (annulus f

118 fusion (pre-F) conformation, with or without replacement of its transmembrane and cytoplasmic tail do

119 ough careful synthesis and characterization, replacement of KBe2 BO3 F2 (KBBF) by a Be-free DUV NLO m

120 ream across the region, as well as continued replacement of large-stream fishes by small-stream fishe

121 (iv) Replacement of LAT with the cpIAP gene does not cause up

122 virus inhibitor of apoptosis (cpIAP) because replacement of LAT with the cpIAP gene resulted in a dif

123 In this study, the replacement of late Mousterian industries by Aurignacian

124 still help prioritize both leak repairs and replacement of leak-prone sections of distribution lines

125 Remarkably, replacement of Leu in 1 and in derivatives of 1 by Trp t

126 Replacement of Leu193 in the substrate C3 pocket with th

127 Strikingly, replacement of leucine(973) in the juxtamembrane region

128 ould be increased by more than 200-fold upon replacement of liposomes with bacteriophage Qbeta virus-

129 versatile methods for targeted insertion or replacement of long sequences and genes, which are neede

130 Replacement of lost beta cells in patients with diabetes

131 An example of such a barrier is that replacement of lost neurons may be insufficient because

132 Cell replacement of lost neurons using enteric neural stem ce

133 YAP(S127A)-induced tumorigenesis, a gradual replacement of LSECs by CECs was associated with dynamic

134 among the analyzed virus strains, except for replacement of lysine with arginine at 378th position of

135 ple clades successively drove the demise and replacement of mackerel sharks due to a failure to origi

136 at products are prone to adulteration by the replacement of meat from more expensive animal species w

137 The replacement of Met76 to Val76 in certain HLA-DPB1 allele

138 tion bonding in M/COF-DB allows for the easy replacement of metal ions through a postsynthetic exchan

139 In the setting of stable CDI incidence, replacement of metronidazole with oral vancomycin is unl

140 In the setting of stable CDI incidence, replacement of metronidazole with oral vancomycin is unl

141 ific therapies, can be prevented by targeted replacement of mitochondrial creatine kinase or mitochon

142 pical diphyodont mammalian system with tooth replacement of most positions.

143 advances in genome engineering, the targeted replacement of mouse genomic regions with orthologous hu

144 ished its virulence enhancement ability, and replacement of mucin with iron significantly enhanced th

145 and valve repair or replacement surgery, the replacement of multiple valves, aortic root reconstructi

146 muscles, thus providing a mechanism for the replacement of muscle by fibrosis and fat.

147 trategies based on AAV are being adapted for replacement of mutant disease-causing genes, knockdown o

148 hmias, myocardial dysfunction and fibrofatty replacement of myocardial tissue.

149 Muscle loss due to fibrotic or adipogenic replacement of myofibers is common in muscle diseases an

150 which this situation results from functional replacement of native by foreign genes, functional mitoc

151 rienced an unprecedented level of functional replacement of native genes by foreign copies.

152 ional replacements occurred via the physical replacement of native genes by foreign genes.

153 al relevance in human evolution, the time of replacement of Neandertals by modern humans during the L

154 ey location in determining the timing of the replacement of Neanderthals by anatomically modern human

155 his leads to clogging, malodor, and possible replacement of nonwater urinals with flush urinals.

156 s of Hox11 function at adult stages leads to replacement of normal lamellar bone with an abnormal wov

157 f cell growth were primarily met through the replacement of nutrients consumed during net macromolecu

158 rom the basal side; this is followed by slow replacement of older claudins in the strands.

159 fense; this process contributes to deficient replacement of olfactory sensory neurons.

160 disorders of the CNS.SIGNIFICANCE STATEMENT Replacement of oligodendroglia and myelin regeneration h

161 Moreover, the replacement of one Calpha-stereogenic center by a nitrog

162 The replacement of one chemical motif with another that is b

163 The formal replacement of one dialkylamino group in rhodamines with

164 Here we show that replacement of one of the main DNA replicases in human c

165 the sites of ubiquitination and showed that replacement of one of them with acetylation-mimicking gl

166 Replacement of p73alpha with p73beta results in the depl

167 alcohol and smoking cessation, pain control, replacement of pancreatic insufficiency, or mechanical d

168 Muscle MRI revealed fat replacement of paraspinal and proximal leg muscles; card

169 sions can be achieved through use of partial replacement of PC with mineral admixtures.

170 ycin-resistant enterococci (VRE) through the replacement of peptidoglycan (PG) stem terminal d-Ala-d-

171 plete structural understanding and potential replacement of pharmaceutically relevant PEGs by alterna

172 Replacement of PICH with its translocase-deficient mutan

173 he routine surveillance, changing policy and replacement of polymyxins by polymyxin derivatives, mole

174 cused on questions related to the repeal and replacement of portions of the Affordable Care Act (ACA)

175 Replacement of R401W with leucine and then lysine progre

176 vestigation was conducted, with the eventual replacement of radiotracers with stable isotopically lab

177 26B1 inhibits injury-induced and age-related replacement of RALDH(-) supporting cells with RALDH1(+)

178 omologues may diverge evolutionarily through replacement of, rather than tinkering with, their ancest

179 Replacement of regular salt with potassium-enriched subs

180 made resistant to ROS activation by knock-in replacement of regulatory domain methionines with valine

181 tween stability and plasticity, facilitating replacement of replisomal components dependent on their

182 ion-coupled histone H3 turnover, driving the replacement of resident H3 nucleosomes with CENP-A(Cnp1)

183 stabilize sharp bends in target DNA, and why replacement of residue 848 by arginine during RAG domest

184 ures include loss of myocytes and fibrofatty replacement of right ventricular myocardium; biventricul

185 terial SRP RNA, providing an example for the replacement of RNA function by proteins during the evolu

186 In contrast, replacement of saturated fat with mostly refined carbohy

187 This method has been used as a replacement of SDS-PAGE for purity analysis of adeno-ass

188 A complete replacement of seasonal vaccines with universal vaccines

189 g, alanine-scanning mutagenesis involves the replacement of selected residues with alanine to determi

190 Taste bud maintenance depends on continuous replacement of senescent taste cells with new ones gener

191 ey have found particular use as bioisosteric replacements of several heteroatomic functional groups,

192 Epidemiologic research has shown that replacement of SFAs with unsaturated fat, but not refine

193 ons, large deletions, targeted insertions or replacements of short sequences, and precise base change

194 antibody fragments by genetic site-specific replacement of single tyrosine residues with photocaged

195 heterozygosity (LOH) events that lead to the replacement of single, functional tumor suppressor genes

196 ide one mechanism to explain the directional replacement of small-ranged species within sites and thu

197 The objective was to evaluate replacement of sodium erythorbate with a natural antioxi

198 ion results in an overall loss and extensive replacement of soil micro- and mesofaunal biodiversity,

199 Replacement of some residues in the juxtamembrane region

200 th solubles (DDGS) as a mixture in a partial replacement of soybean meal (SBM) in broiler finisher di

201 ed us to identify the gain, loss, and strain replacement of specific species and link these events to

202 y, nuclear pores are maintained by piecemeal replacement of subunits, resulting in mosaic complexes c

203 Remarkably, the replacement of sulfur with other heteroatoms results in

204 hioxotriazinoindole cemtirestat by isosteric replacement of sulfur with oxygen in combination with va

205 old of the novel AR inhibitor cemtirestat by replacement of sulfur with oxygen.

206 a rational genomic design based on multiple replacements of synonymous codons.

207 Clonal replacement of T cells was preferentially observed in ex

208 MRI is an imaging measure that reflects the replacement of T2 lesions by cerebrospinal fluid spaces

209 the albumin bound PTX, represents a superior replacement of Taxol(R) that mitigates the side effects

210 eurodevelopment protein 1 (NDE1) gene showed replacement of terminal exon 9 with a mutually exclusive

211 Replacement of testosterone effectively normalized the t

212 Here, we report the successful replacement of tetrathiafulvalene (TTF) with a nickel gl

213 and registry the outcomes after aortic valve replacement of the 4 flow-gradient groups.

214 ates, necrosis and connective tissue and fat replacement of the affected muscles.

215 The replacement of the Al- by an Fe atom leads to a planar b

216 Replacement of the alpha-glucopyranosyl motif in the nat

217 Further optimization through replacement of the amide with a variety of five- and six

218 structural changes to 1 include bioisosteric replacement of the amide with oxadiazole and alpha,alpha

219 Replacement of the amino acid lysine to arginine within

220 issections are often treated with prosthetic replacement of the ascending aorta.

221 t of mitochondria from axon terminals allows replacement of the axon terminal population within a day

222 ls of enantioselectivity are maintained upon replacement of the bulky tert-butyl substituents on the

223 The net replacement of the C1 pro-R hydrogen of 1 by its C2 oxyg

224 hetic collagen is difficult and requires the replacement of the canonical amino acids (4R)-hydroxypro

225 a preclinical model of disease suggest that replacement of the Chkb gene or upregulation of endogeno

226 Replacement of the diseased cells with a healthy donor e

227 Self-replacement of the dominant tree species was only preval

228 n-drug interaction parameters, including the replacement of the drug-albumin adduct by a competitive

229 consequence of skin stripping from the daily replacement of the electrodes.

230 Our proof-of-concept experiments show that replacement of the entire cytoplasm of oocytes from a se

231 homology-directed repair (HDR), resulting in replacement of the excised region with a donor template

232 Hemiarthroplasty (prosthetic replacement of the femoral head) fixation via bony growt

233 y gradually switching from FPP to GPP, until replacement of the final alpha-helix, whereupon cyclopro

234 a 3D-printed nasopharyngeal (3DP) swab as a replacement of the FLNP swab.

235 coli strains were evolved in parallel after replacement of the genes pgi or tpiA with orthologous DN

236 lation of L-type calcium current, as well as replacement of the hERG current model.

237 Chronic GVHD is fundamentally caused by replacement of the host's immune system with donor cells

238 We previously found that replacement of the human-origin PA gene segment in avian

239 A two-pronged strategy, which focused on replacement of the imidazole scaffold and the design of

240 Replacement of the imidazopyridine hinge binding motif p

241 Our findings suggest that replacement of the InBios ZIKV MAC-ELISA with the InBios

242 nt infection (PJI) usually requires surgical replacement of the infected joint and weeks of antibioti

243 A systematic SAR study further revealed that replacement of the key oxygen atom in the linker of the

244 Here, we show that the replacement of the larval epithelia by the adult one in

245 s elegant approach and describe the galvanic replacement of the liquid metal alloy galinstan with Ag

246 Replacement of the LIZ with alanine resulted in dramatic

247 a Monte Carlo simulation framework, partial replacement of the LSL was predicted to result in releas

248 nt by suppression of the immune response and replacement of the microbiota through fecal microbiota t

249 Results suggest that replacement of the Moab WWTP achieved a significant redu

250 Alanine replacement of the motif I residues (AA-E-D; four nucleo

251 cardiac disease characterized by fibrofatty replacement of the myocardium, resulting in heart failur

252 result in chronic inflammation or adipogenic replacement of the myofibers.

253 t chronic muscle inflammation and adipogenic replacement of the myofibers.

254 Replacement of the N-terminal Aib residue of 1 with a De

255 The results indicate that the replacement of the Na(+) counterion by bmim(+) in AOT RM

256 Replacement of the native sequence downstream of a gene

257 rn humans into the rest of Eurasia and their replacement of the Neanderthals.

258 he transport mechanism of GlcP(Se) A neutral replacement of the negatively charged Asp(22) led to pos

259 Replacement of the nucleophilic serine of serine beta-la

260 d mucous membrane grafting (MMG), prosthetic replacement of the ocular surface ecosystem (PROSE) cont

261 inhibits the serine protease trypsin due to replacement of the P1 Leu(15) in the reactive loop with

262 COUPY fluorophores can be fine-tuned through replacement of the para-pyridinium moiety with several h

263 w oligonucleotide monomers was developed for replacement of the phosphodiester backbone of RNA by a s

264 This significant advance was achieved by the replacement of the poorly understood hexamethyldisilazan

265 of noncanonical amino acid mutagenesis, that replacement of the proline residue at position 28 of the

266 ive endocarditis with or without the need of replacement of the pulmonary valve.

267 The intron conversion is formed by a replacement of the segment of DNA within intron 2 of hCY

268 Replacement of the signal peptide of the Spike protein w

269 Replacement of the single biotin by the biotin-Si-NPs bo

270 The IFNAR1*557Gluext*46 resulted in replacement of the stop codon with 46 additional codons

271 Unexpectedly, the replacement of the structural bridging Cl(-) with the mo

272 rophin modulators, based on the bioisosteric replacement of the sulfone group with a phosphinate este

273 Isosteric replacement of the tetrazole ring with a carboxyl group

274 In agreement, pausing was lost upon replacement of the TFIID complex with TATA-binding prote

275 tic methods have been developed that involve replacement of the thioester with a more stable amide or

276 (AML) within three months, characterized by replacement of the thymus with leukemic myeloblasts.

277 of insects extracts standardized for protein replacement of the traditional insect diet with polystyr

278 Replacement of the transmembrane domain of CD74 or the a

279 of TRPswitch were elucidated and allowed for replacement of the TRPswitch azobenzene with a next-gene

280 cursors, which enables selective removal and replacement of the uppermost chalcogen layer, thus trans

281 Replacement of the X residue with the most frequent amin

282 Here, we show that replacements of the positively-charged residues that con

283 rnover throughout life, causing the constant replacement of their synaptic contacts.

284 The slow replacement of these enzymes in spite of young age of mi

285 ved following removal of the ECM/glycocalyx, replacement of these glycosylated asparagines, or remova

286 Replacement of these residues with alanine results in de

287 new method for the selective and sequential replacement of three C-H bonds at the allylic position o

288 However, replacement of TM2 by the transmembrane domain of CD4, t

289 Iran has had the replacement of traditional practices with modern medical

290 2013-2018 began with the synchronized global replacement of trivalent OPV (tOPV) with bivalent OPV (b

291 uantum chemical calculations showed that the replacement of U with Psi affected the intrinsic stackin

292 The replacement of up to 50% tomato pulp by strawberry pulp

293 banion derivatives as potential bioisosteric replacements of ureas and related functional groups.

294 Replacement of V(D)J recombinase targets at two differen

295 e by utilizing nanoliter-sized droplets as a replacement of wells.

296 oped a Burkitt's lymphoma system that allows replacement of wild-type MYC for mutants that are defect

297 kinase inhibition, and CRISPR-Cas9-mediated replacement of WT KRAS with a mutant allele sensitized h

298 Our findings reveal that replacement of XEN cells with ESCs transiently expressin

299 a lower risk of all-cause mortality, whereas replacement of yogurt with red meat, processed meat (wom

300 inine-to-serine change (R764S) in ZF9 and by replacement of ZF11 with two other fingers, yielding 14