ライフサイエンスコーパス: replication competence

1 4V, thereby restoring both Rb regulation and replication competence.

2 maintenance-2 (MCM2) protein was tested for replication competence.

3 thogenic lesions correlated with a defect in replication competence.

4 complex [3], which is necessary to establish replication competence.

5 nt variants was constructed and analyzed for replication competence.

6 eam effector of lamina assembly in promoting replication competence.

7 , although other mutations were required for replication competence.

8 g p53, retinoblastoma, and p107, yet retains replication competence.

9 are relevant for assessing virus tropism and replication competence.

10 l replicons and thus were not sufficient for replication competence.

11 HEL as well as HEL and NS2B are required for replication competence.

12 nd to block replicated DNA from re-acquiring replication competence [2].

13 To assess the in vivo replication competence, all viruses contained a stop cod

14 tance mutations resulted in moderate loss of replication competence, although several (V36A/L/M, R109

15 h a prototype human MERS-CoV to assess virus replication competence and cell tropism in ex-vivo cultu

16 ro-activated cells, we also investigated the replication competence and pathogenic potential of these

17 y to examine age-associated human islet cell replication competence and reveal mechanisms underlying

18 4E10 recognition sequences in gp41 retained replication competence and were used for neutralization

19 ichromosome maintenance (MCM)-2, a marker of replication competence, and mounted in medium containing

20 While proviral replication competence appeared to be associated with th

21 Future studies assessing FL HIV-provirus and replication competence are needed to further evaluate th

22 (i) the YPDL L domain of p9 is required for replication competence (assembly and infectivity) in equ

23 c factors contribute to the establishment of replication competence at OriP.

24 capability; then it finally acquires optimal replication competence by additional mutations when the

25 Replication competence can be restored in these nuclei,

26 Replication competence could be rescued by reinsertion o

27 How oocytes lose and regain replication competence during meiosis are important ques

28 that limit the establishment of the oocyte's replication competence during meiosis.

29 stem of the 3'SL are primary determinants of replication competence for flavivirus genomes.

30 ype CA resulted in significant disruption of replication competence in "chimeric" virions.

31 of individual genes necessary for conferring replication competence in a heterologous host is importa

32 mmune response than NYVAC-C, indicating that replication competence in a poxvirus may improve upon th

33 y to bind retinoblastoma but retaining viral replication competence in cancer cells with a defective

34 e in the central nervous system but maintain replication competence in dividing cell populations, suc

35 horylation also decreased cell-free SV40 DNA replication competence in extracts of treated cells.

36 irus strain NYVAC or a variant with improved replication competence in human cells, termed NYVAC-KC.

37 ted oocytes resume meiosis, re-establish DNA replication competence in meiosis I shortly after germin

38 ingly, the Delta p48 mutant viruses retained replication competence in the apparent absence of p48 fo

39 dapted, variant coxsackievirus A21 exhibited replication competence in the lungs of hICAM-1 transgeni

40 omplete p9 protein were required to maintain replication competence in transfected equine cells; prov

41 dromedary MERS-CoV strains had similar viral replication competence in Vero-E6 cells and respiratory

42 und the nsp6 L232F conferred increased viral replication competence in vitro, in cultures of the uppe

43 strate that despite no overt loss of overall replication competence in vivo, this mutation results in

44 ts antisense ZIKV RNA (asRNA) to assess ZIKV replication competence in ZIKV RNA-positive semen sample

45 Xenopus, the only component missing for DNA replication competence is CDC6, which is synthesized fro

46 Selection for replication competence makes it possible to amplify and

47 Neither recovery of replication competence nor reversal of RPA effects occur

48 The similarity of virus tropism and replication competence of human and dromedary MERS-CoV f

49 ing and demonstrate that Cdt1 influences the replication competence of loaded Mcm2-7 helicases.

50 onential growth in culture does not preclude replication competence of reactivated HIV, and ultrasens

51 The observed replication competence of SHIV(CHN19) requires the full

52 eceived CD8-depleting antibody to assess the replication competence of the residual reservoir.

53 the wild-type WN 3'SL markedly enhanced the replication competence of WN virus in mosquito cells but

54 (4) Replication competence: Polymerase chain reaction (PCR)

55 Despite this loss of replication competence, purified NS5B-C316A protein was

56 HCECs from the peripheral area retain higher replication competence, regardless of donor age.

57 Acquisition of DNA replication competence requires protein synthesis, but t

58 nd that HIV-1 lacking Nef can revert to full replication competence simply by losing the ability to a

59 er component required for acquisition of DNA replication competence that is absent in mouse oocytes.

60 teraction is sufficient to confer autonomous replication competence to AAV in 293 cells.

61 ify sequences that could confer cell culture replication competence to replicons derived from chimpan

62 Replication competence was determined using coculture, w

63 in-treated cells, indicated that reduced DNA replication competence was due to the presence of a tran

64 Replication competence was maintained following either a

65 ave more complex mechanisms to establish DNA replication competence when compared to their Xenopus co

66 These mutations substantially enhanced replication competence when introduced into HRV-14 RNAs