ライフサイエンスコーパス: replication factor C

1 yeast CHL12 and has similarity to mammalian replication factor C.

2 teracts with multiple subunits of Drosophila replication factor C.

3 al DNA template was dependent on PCNA and on replication factor C.

4 nt on proliferating cell nuclear antigen and replication factor C.

5 ncy in stimulation of the ATPase activity of replication factor C.

6 imase, DNA polymerase alpha, DNA ligase, and replication factor C.

7 provides a binding site for the clamp-loader Replication Factor C.

8 lity of PCNA to be loaded onto primed DNA by replication factor C.

9 egions of homology with the five subunits of Replication factor C.

10 pha, proliferating cell nuclear antigen, and replication factor C activate MutLalpha endonuclease to

11 The identification of both replication factor C and DNA helicases as critical for s

12 h three- and four-subunit complexes required replication factor C and proliferating cell nuclear anti

13 dition of M. thermoautotrophicum homologs of replication factor C and proliferating cell nuclear anti

14 rms a replication complex in the presence of replication factor C and proliferating cell nuclear anti

15 PCNA, together with replication factor C and replication protein A, stimulat

16 n A, proliferating cell nuclear antigen, and replication factor C and was active in the SV40 DNA repl

17 quirements for DNA polymerase alpha-primase, replication factor C, and PCNA.

18 ntenance (MCM) 3' --> 5' DNA helicase, PolB, replication factor C, and proliferating cell nuclear ant

19 sence of proliferating cell nuclear antigen, replication factor C, and single-stranded binding protei

20 d circular DNA do in fact support MutSbeta-, replication factor C-, and PCNA-dependent activation of

21 Three distinct forms of replication factor C are known to play vital roles in ge

22 ly loaded around effector DNA by its loader, replication factor C, are ubiquitinated.

23 These functions include loading onto DNA by replication factor C, as well as Okazaki fragment synthe

24 athway, FEN1 was functional without PCNA and replication factor C but required the DNA synthesis, whi

25 PCNA is loaded onto DNA by replication factor C, but it has been unknown how PCNA i

26 structural gene for the large subunit of DNA replication factor C (cdc44/rfc1) causes striking increa

27 ith mutations affecting the large subunit of replication factor C (Cdc44p or Rfc1p) in Saccharomyces

28 repair protein (248kDa) and the five-subunit replication factor C clamp loader (250 kDa).

29 and essential DNA polymerase, and a modified Replication Factor C clamp--loader complex.

30 esis, and the localization and activation of replication factor C complex (RFC) subunits.

31 tion in the large subunit of the replicative replication factor C complex (rfc1-1) increased the expa

32 ase delta/proliferating cell nuclear antigen/replication factor C complex on telomeric templates that

33 pendent phosphorylation; associates with the replication factor C complex, a critical component of th

34 ion: proliferating cell nuclear antigen, the replication factor C complex, DNA polymerase delta, flap

35 FC3 encode three of the five subunits of the replication factor C complex, which is required to load

36 rotein family, which include subunits of the Replication factor C complex.

37 of proteins including components of the DNA replication factor C complex.

38 ohesion establishment factor, the Ctf18-RFC (replication factor C) complex.

39 rase epsilon, replication protein A, and two replication factor C complexes on chromatin.

40 action of FEN1 in the presence of PCNA and a replication factor C-containing fraction.

41 ved in spindle-associated, Ctf18-alternative replication factor C (Ctf18-RFC) clamp loader complex, a

42 log 6, Exonuclease 1, replication protein A, replication factor C-Delta1N, proliferating cell nuclear

43 liferating cell nuclear antigen clamp loader replication factor C, DNA polymerase delta, and DNA liga

44 re assembled around DNA by the clamp loader, replication factor C, efficiently.

45 ng cell nuclear antigen and the clamp loader replication factor C facilitated DNA synthesis with Dpo3

46 ticipation that the discovery of this unique replication factor C homolog will lead to critical insig

47 Human replication factor C (hRFC) is a five-subunit protein co

48 Human replication factor C (hRFC) is a multi-subunit protein c

49 a its non-conserved C-terminal domain (CTD); replication factor C interaction results in approximatel

50 Replication factor C is required to load proliferating c

51 Eukaryotic replication factor C is the heteropentameric complex tha

52 conformations matching the helical pitch of Replication Factor C, it is not biased toward a right-ha

53 Here we show that the Elg1 replication factor C-like complex (Elg1-RLC) functions i

54 factor is loaded onto DNA by the Rad24-RFC (replication factor C-like complex with Rad24) clamp load

55 es now present data strongly implicating the replication factor C-like complex, Elg1/ATAD5-RLC, in th

56 Then replication factor C loads a proliferating cell nuclear

57 the nascent strand from polymerase alpha to replication factor C, one possibility is that this step

58 tant showed a defect in the interaction with replication factor C or in loading by this complex.

59 ix purified human proteins: AP endonuclease, replication factor C, PCNA, flap endonuclease 1 (FEN1),

60 S. pombe Uve1p, Rad2p, DNA polymerase delta, replication factor C, proliferating cell nuclear antigen

61 system comprised of MutS alpha, MutL alpha, replication factor C, proliferating cell nuclear antigen

62 th the 9-1-1 heterotrimer reminiscent of the replication factor C/proliferating cell nuclear antigen

63 Condensin, minichromosome maintenance, and replication factor C protein complexes were identified a

64 subunits of the origin recognition complex, replication factor C proteins, MCM DNA-licensing factors

65 ating cell nuclear antigen (PCNA) loading by replication factor C, providing a potential mechanism fo

66 The human DNA damage sensors, Rad17-replication factor C (Rad17-RFC) and the Rad9-Rad1-Hus1

67 ation factors, and the clamp loader complex (replication factor C) remained tethered to chromatin.

68 Replication factor C (RF-C) and proliferating cell nucle

69 The five subunit replication factor C (RF-C) complex plays a critical rol

70 Replication factor C (RF-C) complex plays an important r

71 Replication factor C (RF-C) is a five subunit DNA polyme

72 Yeast replication factor C (RF-C) is a heteropentamer encoded

73 Eukaryotic replication factor C (RF-C) is a heteropentameric comple

74 Replication factor C (RF-C), a complex of five subunits,

75 Replication factor C (RF-C), a complex of five subunits,

76 ating cell nuclear antigen (PCNA) loading by replication factor C (RFC) acts as the initial sensor of

77 oliferating cell nuclear antigen (PCNA), and replication factor C (RFC) and a reconstituted Mlh1-Pms1

78 , proliferating cell nuclear antigen (PCNA), replication factor C (RFC) and DNA polymerase delta.

79 plication clamp PCNA is loaded around DNA by replication factor C (RFC) and functions in DNA replicat

80 Replication factor C (RFC) and proliferating cell nuclea

81 Fractions that contained replication factor C (RFC) and proliferating cell nuclea

82 en (PCNA), and show that PCNA, together with replication factor C (RFC) and replication protein A (RP

83 The human clamp loader replication factor C (RFC) and sliding clamp proliferati

84 PCNA loading is catalyzed by Replication factor C (RFC) and the Ctf18 RFC-like comple

85 Replication factor C (RFC) and the proliferating cell nu

86 Replication factor C (RFC) and the proliferating cell nu

87 of the Saccharomyces cerevisiae clamp loader Replication Factor C (RFC) bound to its cognate sliding

88 Replication factor C (RFC) catalyzes assembly of circula

89 The eukaryotic equivalents are the replication factor C (RFC) clamp loader and the prolifer

90 The eukaryotic replication factor C (RFC) clamp loader is an AAA+ spira

91 However, unlike the loading of PCNA by the replication factor C (RFC) clamp loader onto 3'-recessed

92 We find that the replication factor C (RFC) clamp loader specifically inh

93 , and D subunits of Saccharomyces cerevisiae replication factor C (RFC) clamp loader, respectively, a

94 PCNA sliding clamps are loaded onto DNA by a replication factor C (RFC) clamp loader.

95 ell nuclear antigen (PCNA) sliding clamp and replication factor C (RFC) clamp-loading complex, using

96 ELG1 protein, which comprises an alternative replication factor C (RFC) complex and plays an importan

97 The multi-subunit replication factor C (RFC) complex loads circular prolif

98 visiae, this process involves an alternative replication factor C (RFC) complex that contains the fou

99 oliferating cell nuclear antigen (PCNA), the replication factor C (RFC) complex, DNA polymerase delta

100 Central to this process is the replication factor C (RFC) complex, encompassing five su

101 s, sliding clamps are loaded onto DNA by the replication factor C (RFC) complex, which consists of fi

102 igated the communication between subunits in replication factor C (RFC) from Archaeoglobus fulgidus.

103 e Methanosarcina acetivorans clamp loader or replication factor C (RFC) homolog.

104 of the Saccharomyces cerevisiae clamp loader Replication Factor C (RFC) in absence of sliding clamp o

105 s that are loaded onto DNA by clamp loaders [replication factor C (RFC) in eukaryotes].

106 Replication factor C (RFC) is a five-subunit complex tha

107 Replication factor C (RFC) is a five-subunit protein com

108 Replication Factor C (RFC) is a five-subunit protein com

109 Replication factor C (RFC) is a heteropentameric AAA+ pr

110 ing cell nuclear antigen loading onto DNA by replication factor C (RFC) is a key step in eukaryotic D

111 Replication factor C (RFC) is an AAA+ heteropentamer tha

112 netic experiments reveal that ATP binding to replication factor C (RFC) is sufficient for loading the

113 tural studies of the eukaryotic clamp loader replication factor C (RFC) revealed that it functions us

114 Rad17 homologs have extensive homology with replication factor C (RFC) subunits (p36, p37, p38, p40,

115 tin by a complex of Rad17 and the four small replication factor C (RFC) subunits (Rad17-RFC) in respo

116 d DNA binding site in the yeast clamp loader replication factor C (RFC) that aids in binding to nicke

117 Pase, is the bacterial homolog of eukaryotic replication factor C (RFC) that loads the sliding clamp

118 24 interacts with the four small subunits of replication factor C (RFC) to form the RFC-Rad24 complex

119 Additionally, we show a unique ability of replication factor C (RFC) to stimulate Poldelta lesion

120 The Ctf18-RFC PCNA loader, a replication factor C (RFC) variant, is specific to the l

121 ometry to contain Rfc2 and Rfc3, subunits of replication factor C (RFC), a five subunit protein that

122 Replication factor C (RFC), a heteropentamer of RFC1-5,

123 In addition, DNA replication factor C (RFC), a protein complex that facil

124 and DNA binding by Saccharomyces cerevisiae replication factor C (RFC), and present the first kineti

125 tein A (RFA), the 3' primer binding complex, replication factor C (RFC), and proliferating cell nucle

126 l nuclear antigen (PCNA) and show that PCNA, replication factor C (RFC), and replication protein A (R

127 y the Saccharomyces cerevisiae clamp loader, replication factor C (RFC), and the DNA damage checkpoin

128 The clamp loader, replication factor C (RFC), can reverse this mark by unl

129 When loaded onto primed DNA templates by replication factor C (RFC), PCNA acts to tether the poly

130 the processivity factor PCNA and its loader, replication factor C (RFC), preventing normal fork resta

131 tionation of these crude extracts identified replication factor C (RFC), proliferating cell nuclear a

132 several DNA replication proteins, including replication factor C (RFC), proliferating cell nuclear a

133 on, hLigI interacts with and is inhibited by replication factor C (RFC), the clamp loader complex tha

134 is study, we describe an association between replication factor C (RFC), the clamp loader, and DNA li

135 l nuclear antigen, a DNA sliding clamp, and, replication factor C (RFC), the clamp loader.

136 dogenous and transfected Brd4 interacts with replication factor C (RFC), the conserved five-subunit c

137 utation in RFC4, encoding a small subunit of replication factor C (RFC), was found to display allele-

138 around DNA by the ATP-dependent clamp loader replication factor C (RFC), which acts at single-strande

139 Unlike replication factor C (RFC), which uses the 3' primer/tem

140 A function, we have designed a new assay for replication factor C (RFC)-catalyzed loading of PCNA ont

141 proliferating cell nuclear antigen (PCNA) in replication factor C (RFC)-catalyzed loading of the clam

142 e-molecule analysis, we demonstrate that the replication factor C (RFC)-CTF18 clamp loader (RFC(CTF18

143 hat Ctf18, Ctf8, and Dcc1, the subunits of a Replication Factor C (RFC)-like complex, are essential f

144 loaded onto the primer-template junction by replication factor C (RFC).

145 gment synthesis by the AAA(+) heteropentamer replication factor C (RFC).

146 with proliferating cell nuclear antigen and replication factor C (RFC).

147 nctions by a clamp loader molecular machine, replication factor C (RFC).

148 tf18, a homologue of the p140 subunit of the replication factor C (RFC).

149 interact with their associated clamp loader, replication factor C (RFC).

150 r antigen (PCNA), and hRad17 has homology to replication factor C (RFC).

151 tead stabilizes the site, protecting it from replication factor C (RFC)/PCNA-induced melting.

152 DNA requires the activity of a clamp-loader [replication factor C (RFC)] complex and the energy deriv

153 a nucleotide-bound eukaryotic clamp loader [replication factor C (RFC)] revealed a different and mor

154 Human replication factor C (RFC, also called activator 1) is a

155 Replication factor C (RFC, also called activator 1), in

156 Replication factor C (RFC, also called Activator I) is p

157 ating cell nuclear antigen (PCNA, clamp) and replication factor C (RFC, clamp loader), we have examin

158 The DNA damage clamp loader replication factor C (RFC-Rad24) consists of the Rad24 p

159 Replication-Factor-C (RFC) and RFC-like complexes (RLCs)

160 CTF7/ECO1, POL30 (PCNA), and CHL12/CTF18 (a replication factor C [RFC] homolog) genetically interact

161 loader gamma complex (homolog of eukaryotic Replication Factor C, RFC).

162 re of the five-protein clamp loader complex (replication factor-C, RFC) of the yeast Saccharomyces ce

163 the structural gene for the large subunit of replication factor C (rfc1), which loads PCNA onto DNA,

164 s two similar small subunits (M. acetivorans replication factor C small subunit (MacRFCS)) and one la

165 ucturally homologous proteins, including the replication factor-C small subunit (RFCS).

166 lelic intronic AAGGG repeat expansion in the replication factor C subunit 1 (RFC1) gene as the cause

167 repeat sequence motifs are possible in RFC1 (replication factor C subunit 1), encoding the DNA replic

168 ding proteins have been reported previously: replication factor C (the PCNA clamp loader), family B D

169 loaded onto the template-primer junction by replication factor C, the C-terminal domain of PCNA medi

170 this process through a pathway that includes replication factor C, the chromatin assembly factor Asf1

171 mplex, leading to ineffective recruitment of replication factor C to initiate DNA replication.

172 The ATPase activity of replication factor C was characterized and found to be s

173 a circular substrate without the addition of replication factor C, which is the protein responsible f

174 nterfaces by the ATP-dependent clamp loader, Replication Factor C, whose clamp-interacting sites form

175 loaded onto DNA by a dedicated complex, the replication factor C, whose mechanism has been studied i

176 Complexes of replication factor C with a N-terminal truncation (Delta

177 gammaS), a nonhydrolyzable analog of ATP, to replication factor C with a N-terminal truncation (Delta

178 Our results demonstrate that S. cerevisiae Replication Factor C (yRFC) can load yPCNA onto 5'-ssDNA