ライフサイエンスコーパス: replication machinery

1 elps solve a wide range of challenges to the replication machinery.

2 on viral factors E1 and E2 and the cellular replication machinery.

3 lear antigen and other components of the DNA replication machinery.

4 tes and interacts with the components of the replication machinery.

5 matin pose significant challenges to the DNA replication machinery.

6 ichromosomes that are replicated by the host replication machinery.

7 s stimulated by interaction of Eco1 with the replication machinery.

8 rus encodes most, if not all, of its own DNA replication machinery.

9 ing the virus to gain access to the cellular replication machinery.

10 merase holoenzyme is a unique feature of the replication machinery.

11 active process, not a titration of maternal replication machinery.

12 essential role at the core of the minicircle replication machinery.

13 emphasizing their functional role in T4 DNA replication machinery.

14 ynthesis of the C strand by the conventional replication machinery.

15 nable to productively interact with the Con1 replication machinery.

16 ntigen (PCNA), an essential component of the replication machinery.

17 t and interacts with components of the viral replication machinery.

18 with components of the viral translation and replication machinery.

19 and polymerase that is seen in the bacterial replication machinery.

20 iting primase, an essential component of the replication machinery.

21 nism that is coupled to the conventional DNA replication machinery.

22 at each is a critical component of the viral replication machinery.

23 SF1 is important for the processivity of the replication machinery.

24 e DNA loaded gp45 coupled late transcription-replication machinery.

25 of the genome as accessory helicases to the replication machinery.

26 at functions in organizing the mutagenic DNA replication machinery.

27 cation forks and directly interacts with the replication machinery.

28 ns as a stimulatory regulator of NS5B in HCV replication machinery.

29 rus DNA can be replicated solely by the host replication machinery.

30 opoisomerases may also function ahead of the replication machinery.

31 ecruitment to DNA lesions encountered by the replication machinery.

32 lycosides with stem-loop I (SLI) of the IncB replication machinery.

33 NA lesions that block the progression of the replication machinery.

34 e question of how they are recognized by the replication machinery.

35 ly associates with any components of the DNA replication machinery.

36 the replication fork are key elements of the replication machinery.

37 binding protein (OBP) that recruits the core replication machinery.

38 lesions in the template strand block the DNA replication machinery.

39 and they serve to concentrate the viral RNA replication machinery.

40 that MUM2 influences the function of the DNA replication machinery.

41 ng of PCNA, a requisite component of the DNA replication machinery.

42 en clamp loader/sliding clamp complex of the replication machinery.

43 could play a role in lesion bypass by the T4 replication machinery.

44 usly unrecognized function of the eukaryotic replication machinery.

45 been replicated in their entirety by the T4 replication machinery.

46 V light-induced DNA lesions block the normal replication machinery.

47 the expression of specific components of the replication machinery.

48 mma B, a core component of the mitochondrial replication machinery.

49 ia might also be recognized by borrelial DNA replication machinery.

50 ic chromatin structure, and the conventional replication machinery.

51 ognized viral strategy to access the nuclear replication machinery.

52 after inducing the accumulation of host DNA replication machinery.

53 rentiation program and inducing the host DNA replication machinery.

54 ure that aids DNA to segregate away from the replication machinery.

55 prevent deleterious effects on the cellular replication machinery.

56 olve interference with this component of the replication machinery.

57 (DHFR), as well as the components of the DNA replication machinery.

58 y and functioning of the viral transcription/replication machinery.

59 s of infected cells to set up the functional replication machinery.

60 ex) helicase and triggers disassembly of the replication machinery.

61 te interactions with other components of the replication machinery.

62 l coordination between the transcription and replication machinery.

63 amage and secondary structures can stall the replication machinery.

64 nclear if they interact differently with the replication machinery.

65 ng interactions with other components of the replication machinery.

66 use them for the construction of functional replication machinery.

67 spatially distinct from that occupied by the replication machinery.

68 Twinkle disease variants and the core mtDNA replication machinery.

69 lesions and their recognition by the E. coli replication machinery.

70 inds the DNA double helix ahead of the other replication machinery.

71 constitutes an inevitable challenge for the replication machinery.

72 arities between the bacterial and eukaryotic replication machineries.

73 y block the progression of transcription and replication machineries.

74 quires the separate trafficking of the viral replication machinery, a matrix protein (M) and a glycop

75 y creates a requirement for reloading of the replication machinery, a potentially mutagenic process.

76 anifested in coordinated mobilization of the replication machinery, a process that we hypothesize may

77 the replication compartment allow the virus replication machinery an access to plentiful ATP, facili

78 (poliota), like poleta, associates with the replication machinery and accumulates at stalled replica

79 alpha as an essential component of the mtDNA replication machinery and as the first component of the

80 protein NSP2 is a component of the rotavirus replication machinery and binds single-stranded RNA coop

81 ell division will occur and which places the replication machinery and chromosomal loci at defined lo

82 Collisions between the DNA replication machinery and co-transcriptional R-loops can

83 t replication forks to avoid stalling of the replication machinery and consequent genomic instability

84 hese genomes are fully dependent on the host replication machinery and contribute few, if any, replic

85 in interphase nuclei to both engage the host replication machinery and enable the plasmids to adhere

86 l conservation of some components of the DNA replication machinery and enzymes for DNA precursor bios

87 o0A are genes encoding components of the DNA replication machinery and genes that govern flagellum bi

88 es is significant, since dissociation of the replication machinery and inability to efficiently recov

89 sequence of T. litoralis with a focus on the replication machinery and inteins.

90 proteins are critical components of the DNA replication machinery and mark the site of initiation.

91 progression, and Claspin interacts with the replication machinery and might therefore monitor normal

92 mited by incompatibilities between the viral replication machinery and orthologs of essential host fa

93 a large dsDNA virus that encodes its own DNA replication machinery and other enzymes involved in DNA

94 entire process of TLS in vitro using E. coli replication machinery and Pol IV, we observed that a rep

95 Comparing the DNA replication machinery and processes of parasites and the

96 ion through distinct pathways to inhibit the replication machinery and provide evidence that stepwise

97 must also be copied by the conventional DNA replication machinery and replenished by telomerase, sug

98 s of chromosomal replication can disrupt the replication machinery and result in mutagenesis or letha

99 ncluding other transcribing polymerases, the replication machinery and several types of DNA damage, s

100 udes cellular repair pathways can arrest the replication machinery and stall the cell cycle.

101 replication origins) modulate the ubiquitous replication machinery and supports an emerging model tha

102 nce of DNA "ends" poses problems for the DNA replication machinery and the cell's damage response sys

103 e mutagenic, their interference with the DNA replication machinery and the elicited DNA damage respon

104 the combined action of the conventional DNA replication machinery and the reverse transcriptase, tel

105 We also discuss adaptations of the replication machinery and the role of chromatin modifica

106 action of telomerase, the semi-conservative replication machinery and the stabilization of the repli

107 an essential and conserved component of the replication machinery, and a DNA structure reveals a mec

108 dence that the YSS is essential to the viral replication machinery, and contributes to replication en

109 een histone methylation and the metazoan DNA replication machinery, and defining a pivotal aetiologic

110 eracts with PCNA, a central component of the replication machinery, and is recruited to sites of DNA

111 dc45, MCM2-7 and PCNA, components of the DNA replication machinery, and is required for normal replic

112 known E. coli DNA polymerases, parts of the replication machinery, and RecA recombinase.

113 ltiple cellular pathways, including cellular replication machinery, and recruits them to the viral or

114 erative DNA binding, recruitment of cellular replication machinery, and replication function.

115 r DNA amplification, emulating the bacterial replication machinery, and resembling PCR but under isot

116 , is co-expressed with components of the DNA replication machinery, and that Donson is essential for

117 (PCNA), the platform for assembly of the DNA replication machinery, and that unloading of Rad51 by Sr

118 ted cells by parasitism of the intact virus' replication machinery, and through replication with the

119 , archaea have only a subset of the eukaryal replication machinery, apparently needing fewer polypept

120 nded DNA-binding proteins (SSBs) and the DNA replication machinery are found in all organisms, but th

121 er, several core components of the bacterial replication machinery are unrelated or only distantly re

122 hich the high-fidelity DNA polymerase in the replication machinery arrested at the primer terminus is

123 interaction between the cohesin ring and the replication machinery as well as failure to establish SM

124 nition complex 2 (Orc2), a member of the DNA replication machinery, as a Plk1 substrate and have show

125 re we review how cohesin is regulated by the replication machinery, as well as recent evidence that c

126 synthate produced by plants, and viruses use replication machinery at the host's expense.

127 gulation of CDK activity interfaces with the replication machinery at two discrete execution points.

128 ssion of the nascent DNA or migration of the replication machinery away from the blocking lesion to a

129 estigated whether they induce pausing of the replication machinery before serving as the template bas

130 e data indicate that the activity of the DNA replication machinery, beyond TP53 mutation status, dete

131 genomes are translated to produce the viral replication machinery but must then serve as a template

132 e ORF3 sequence, were tolerated by the viral replication machinery, but infectious virus could not be

133 Although known components of the replication machinery can influence telomere length equi

134 ovel insight into the mechanism by which the replication machinery can switch between replication, pr

135 argest RNA viruses, and their genomes encode replication machinery capable of efficient replication o

136 components of the mitochondrial DNA (mtDNA) replication machinery cause mtDNA depletion syndromes (M

137 DNA damage and perturbation of replication machinery causes replication stress, charact

138 NA hybrids (R-loops) and collisions with the replication machinery causing replication stress and DNA

139 propose that MutS directly contacts the DNA replication machinery, causing a dynamic change in the o

140 genome increases the error frequency of the replication machinery, causing mutations that contribute

141 ir of the damage but also changes in the DNA replication machinery, chromatin, and transcription that

142 to the inherent limitations of the canonical replication machinery, chromosomes gradually lose termin

143 syltransferase PARP14 interacts with the DNA replication machinery component PCNA and promotes replic

144 The viral replication machinery consists of four nonstructural pro

145 These findings suggest the presence of replication machinery-coupled and -independent pathways

146 or is more feasible both in the light of the replication machinery currently found in cells and the c

147 How the transcription and replication machineries deal with the presence of cohesi

148 tylation occurs only in association with the replication machinery: disruption of the interaction bet

149 quently, prophage DNA is spooled through the replication machinery, drawing the prophage ends togethe

150 s thought that stalling of the mitochondrial replication machinery during DNA synthesis is a prominen

151 predicted to come into contact with the DNA replication machinery during fork arrest.

152 ransits from being dependent on the cellular replication machinery during latency to commandeering bo

153 sable phage Mu and the host Escherichia coli replication machinery during repair of Mu insertions, wh

154 nthesized histones and components of the DNA replication machinery during the S phase of the cell div

155 The E. coli replication machinery employs a beta clamp that tethers

156 anism of mtDNA replication predicts that the replication machinery encounters dsDNA and unique physic

157 ssociation between PI4KIIIbeta and the viral replication machinery exists and, if it does, whether as

158 ssion of the six components of the EBV lytic replication machinery failed to rescue replication by Z(

159 confront cellular repair, transcription, and replication machinery following exposure to TPZ and offe

160 DNAzyme sequences are implemented as nicking/replication machineries for the amplified, multiplexed a

161 ly in order to concentrate and arrange viral replication machinery for efficient viral RNA synthesis.

162 avirus type 1 (BPV1) depends heavily on host replication machinery for genome duplication.

163 tivating and highjacking the host cell's DNA replication machinery for its own reproduction purposes

164 E2, papillomaviruses depend heavily on host replication machinery for replication of their viral gen

165 a as nuclear plasmids and rely upon the host replication machinery for replication.

166 ncer elements work together with the general replication machinery for site-specific origin utilizati

167 The DNA replication machinery frequently encounters impediments

168 asmid was constructed containing the plasmid replication machinery from a representative Escherichia

169 Our results indicate that the core DNA replication machinery from plants is more similar to ver

170 malian telomeres pose a challenge to the DNA replication machinery, giving rise to replication-depend

171 The Escherichia coli DNA replication machinery has been used as a road map to unc

172 Presumably, either the plastid replication machinery has means of removing nucleoid pro

173 bble and promoting the assembly of the viral replication machinery; however, direct confirmation of t

174 on the synthesis of components of the 29 DNA replication machinery (i.e., terminal protein and DNA po

175 i/regions pose greater challenges to the DNA replication machinery (i.e., the replisome) than others.

176 RTP, and suggest that RTP interacts with the replication machinery in a manner that directly contribu

177 The simplified replication machinery in archaea may provide a simplifie

178 icative polymerases, suggesting that the DNA replication machinery in bacteria arose independently.

179 y to encode additional components of the DNA replication machinery in C. elegans.

180 receptor tyrosine kinase to the nuclear DNA replication machinery in cancer cells.

181 , (R)-sBu and (S)-sBu, are recognized by DNA replication machinery in HEK293T human embryonic kidney

182 provide a comprehensive view of the core DNA replication machinery in plants.

183 alkyl-PTE lesions are recognized by the DNA replication machinery in prokaryotic cells and reveal th

184 s, and of the functional organization of the replication machinery in response to replication stress.

185 deletion mutant parasitism of the wild-type replication machinery in superinfected cells.

186 e progression and activate the host cell DNA replication machinery in these cells, changes essential

187 hysically associated with the lagging-strand replication machinery in these complexes.

188 ing the differences and peculiarities of the replication machinery in trypanosomatids, including how

189 acts with the processivity factor of the DNA replication machinery in vivo and in vitro.

190 are made accessible to the transcription and replication machinery in vivo.

191 HSV-1's replication machinery includes a trimeric helicase-prima

192 en the bacterial and the archaeal/eukaryotic replication machineries, including but not limited to de

193 the normal progression of the mitochondrial replication machinery, including DNA unwinding by Twinkl

194 a large dsDNA virus that encodes its own DNA replication machinery, including enzymes involved in nuc

195 ism by which essential components of the DNA replication machinery interact with the replication chec

196 with the cell membrane to release the viral replication machinery into the host cell's cytoplasm.

197 DNA-replication machinery introduces intertwining and superc

198 The DNA replication machinery invariably encounters obstacles th

199 The DNA replication machinery is an important target for antibio

200 nome duplication, the progression of the DNA replication machinery is challenged by limitations in nu

201 This analysis establishes that the core DNA replication machinery is highly conserved across plant s

202 Assembly of the replication machinery is highly conserved and tightly re

203 The replication machinery is highly regulated by replication

204 icance of the components of the rabies virus replication machinery is incomplete.

205 How the replication machinery is loaded at origins of DNA replic

206 lymerases (pol) iota and Rev1 at the stalled replication machinery is mediated by the ubiquitin-bindi

207 tion between DnaA bound at each site and the replication machinery is not required for regulation of

208 A unique topological challenge to the replication machinery is posed by RNA-DNA hybrids, commo

209 plication of the latent genome, the cellular replication machinery is recruited.

210 strongly supports a hypothesis that the DNA replication machinery is required for proper sister chro

211 DNA replication machinery is responsible for accurate and ef

212 Since virus lacks its own replication machinery, it utilizes the cellular proteins

213 weight (24K) protease, in the absence of the replication machinery (K.

214 ocess requires de novo assembly of the viral replication machinery, large ribonucleoprotein complexes

215 DNA damage can stall the DNA replication machinery, leading to genomic instability.

216 nd two templates T(A) and T(B) and a nicking/replication machinery leads to the cleavage of the hairp

217 ker scaffolds coupled to the polymerase/dNTP replication machinery leads, in the presence of a primer

218 Components of the DNA replication machinery localize into discrete subnuclear

219 en either the template DNA is damaged or the replication machinery malfunctions.

220 y provides the first suggestion that the DNA replication machinery may have redox-sensitive activitie

221 n the opposite direction, at which stage the replication machinery may simply dissociate before the n

222 t, it has been proposed that the herpesvirus replication machinery might replicate AAV DNA.

223 owever, the access of TLS polymerases to the replication machinery must be kept tightly in check to a

224 ich during re-synthesis of resected DNA, the replication machinery must catch up with the preceding p

225 The Escherichia coli DNA replication machinery must frequently overcome template

226 ed during early eukaryote evolution from the replication machinery of a retrotransposable element.

227 ential to invert is probably inherent in the replication machinery of all herpesviruses, irrespective

228 Molecular parasites that utilize the replication machinery of cells or of in vitro amplificat

229 AR co-sedimented with components of the DNA replication machinery of cells that entered S phase.

230 Virophages are viruses that rely on the replication machinery of other viruses to reproduce with

231 H endonuclease superfamily, we show that the replication machinery of the CRESS-DNA viruses evolved,

232 In the case of adenovirus coinfection, the replication machinery of the host cell performs AAV DNA

233 Satellite RNAs usurp the replication machinery of their helper viruses, even thou

234 t Activation (INPACT) system is based on the replication machinery of tobacco yellow dwarf mastreviru

235 ackaging into BV virions may depend upon the replication machinery of wasps.

236 gin proximal genes, but interaction with the replication machinery or other features of DNA structure

237 The mechanism by which the eukaryotic DNA-replication machinery penetrates condensed chromatin str

238 The DNA replication machinery plays additional roles in S phase

239 prevents the collision of transcription and replication machineries, plays a key role in maintaining

240 ors of chromatin assembly/remodeling and DNA replication machineries (POLE3/CHRAC17 and POLE4), the s

241 The bacterial DNA replication machinery presents new targets for the devel

242 ve a simplified subset of the eukaryotic DNA replication machinery proteins and possess initiators th

243 y role in assembling and recruiting the core replication machinery proteins in the initial stages of

244 transient cotransfection, the six KSHV core replication machinery proteins successfully replicated a

245 xtures of the purified T4 late transcription-replication machinery proteins: gp45 (sliding clamp), gp

246 vitro reconstitution of the bacteriophage T4 replication machinery provides a novel system for fast a

247 hromatin, the physiological substrate of DNA replication machinery, regulates DNA replication remains

248 ic double-strand break demonstrated that the replication machinery (replisome) and DNA synthesis are

249 through origin-independent reloading of the replication machinery (replisome) to ensure complete dup

250 foci in positions similar to that of the DNA replication machinery (replisome).

251 Collisions between cellular DNA replication machinery (replisomes) and damaged DNA or im

252 ously visualized replication origins and the replication machinery (replisomes) inside live cells.

253 tions that mimic those in cycling cells, the replication machinery showed substantial stalling at sit

254 To appropriate the cellular DNA replication machinery, simian virus 40 (SV40) large T an

255 ould alter a key functional component of the replication machinery, specifically DnaG primase.

256 ch these DNA polymerases are targeted to the replication machinery stalled at a lesion site has remai

257 that the targeting of this polymerase to the replication machinery stalled at a lesion site is achiev

258 e manner by which hPoleta is targeted to the replication machinery stalled at a lesion site remains u

259 votal role in the targeting of Poleta to the replication machinery stalled at DNA lesions, interactio

260 a repair enzyme as a component of the viral replication machinery suggests that, for poxviruses, DNA

261 airpins and to the activation of the nicking/replication machineries that synthesize two "genes", e.g

262 components of the kinetoplastid nuclear DNA replication machinery - the factors that demarcate sites

263 ir coupling to a nicking/polymerization/dNTP replication machinery, the amplified high-throughput eme

264 nt proteins to M and to a constituent of the replication machinery, the phosphoprotein (P).

265 ombe exploits the intrinsic asymmetry of DNA replication machinery--the difference between the replic

266 Movement of the DNA replication machinery through the double helix induces a

267 Depriving viruses of crucial replication machinery, TIPs would reduce viral loads.

268 viruses are small DNA viruses that use plant replication machinery to amplify their genomes.

269 sating for the inability of conventional DNA replication machinery to completely duplicate the ends o

270 nding, where the virus utilizes the host DNA replication machinery to establish itself as a low-copy-

271 on-like [KIL-d] element reprograms the viral replication machinery to induce mutagenesis and genomic

272 However, how FANCM interacts with the replication machinery to promote traverse remains unclea

273 damage tolerance process that allows the DNA replication machinery to replicate past nucleotide lesio

274 ction(s) can be compensated by the bacterial replication machinery to support the PCV DNA replication

275 e case), strongly indicating attempts by the replication machinery to surpass the stalled replication

276 ind boxes I and II, permitting access of the replication machinery to the Ori(s) sequences.

277 face that may be critical for recruitment of replication machinery to the oriP Our results reveal a n

278 nstead, KSHV LANA recruits the host cell DNA replication machinery to the replication origin.

279 CMG helicase powers ahead of the eukaryotic replication machinery to unwind DNA, in a process that r

280 e results indicate the ability of alphavirus replication machinery to use a multitude of AU-rich RNA

281 der to propagate, AAV relies on the cellular replication machinery together with functions supplied b

282 -stranded DNA genome that relies on cellular replication machinery together with functions supplied b

283 est a spatial reorganization of the host DNA replication machinery upon HPV DNA replication or E1 and

284 to Escherichia coli, and that the endogenous replication machinery uses them to accurately replicate

285 The DNA replication machinery, various regions of the chromosome

286 nce for a direct recruitment of UHRF1 by the replication machinery via DNA ligase 1 (LIG1).

287 lt, whereby proteins can be recruited to the replication machinery via the back of PCNA and be held i

288 o direct interaction of IFI35 with the viral replication machinery was observed, we found that IFI35

289 and downstream components of the processive replication machinery was specifically disrupted.

290 ial physical interaction of ATM with the DNA replication machinery, we found that ATM co-precipitates

291 iated proteins that are not part of the core replication machinery were shown to affect the timing of

292 the interplay between the recombination and replication machinery when recombination intermediates a

293 evidence that poleta targets poliota to the replication machinery, where it may play a general role

294 DNA replication depends on host cellular DNA replication machinery, whereas lytic cycle DNA replicati

295 plification (cHDA) system is based on the T7 replication machinery, which includes the processive T7

296 d stably maintaining the architecture of the replication machinery while keeping the fork moving.

297 -chromatin contacts allow passage of the DNA replication machinery while PSC-PSC interactions prevent

298 n and to study the interactions of the viral replication machinery with the host cell innate immune s

299 molecules to measure the activity of the DNA-replication machinery with the visualization of fluoresc

300 n of telomeres requires the conventional DNA replication machinery, yet little is known about how DNA