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2 nonpolar (D76V and D76I) residues increased replicational accuracy, while substitutions with negativ
5 formation, and the various components of the replicational and transcriptional machinery may be inter
6 substitutions displayed transcriptional and replicational asymmetries consistent with mutations resu
7 and delta, respectively, and show that post-replicational bypass of UV-damaged DNA is severely inhib
9 tions favour the view that the process is co-replicational: DNA replication forks are anchored at the
10 recombination and sex has been selection for replicational fidelity and viability; without the recomb
11 sitive determinants of both dNTP binding and replicational fidelity within the highly conserved motif
12 appear symmetrical in both replichores (i.e. replicational halves of circular chromosomes) and most s
14 Our findings suggest the possibility of co-replicational or co-transcriptional folding of G-quadrup
16 nalogies between the genome organization and replicational requirements of plant closteroviruses and
20 ighlight the potential importance of chronic replicational stress in promoting cancer development.
21 the ATR/Chk1- and 53BP1-mediated signal from replicational stress is received, BLM functions in multi
23 own that exposure of cells to high levels of replicational stress leads to permanent proliferation ar
24 y of mutant p53 to prevent arrest induced by replicational stress per se is primarily dependent on pr
28 es to therapeutically relevant low levels of replicational stress that allow limited proliferation.
29 the ERCC1-XPF endonuclease, is important for replicational stress tolerance in both budding and fissi
31 ests that, in response to DNA damage and DNA replicational stress, Chk1 and Chk2 may phosphorylate Cd