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1 ll potential that allows them to self-renew, repopulate a damaged tissue, and then undergo differenti
2 esn't impair their ability to engraft and to repopulate a functional multilineage hematopoietic syste
3 of larvae (e.g., the refugia hypothesis) to repopulate a select subset of the shallow water (<30 m)
4 ertheless, the capacity of cultured cells to repopulate a wounded monolayer is markedly accelerated b
7 to cytoablative stress, and exhibit superior repopulating ability and self-renewal upon serial transp
8 of its rich content of cells with sustained repopulating ability in spite of an apparent deficiency
11 ser extent HIF-1alpha, impedes the long-term repopulating ability of human CD34(+) umbilical cord blo
12 g dilution analysis, to assess the long-term repopulating ability of putative murine EpiSC population
14 ipients significantly impaired the long-term repopulating ability of transplanted mouse HSCs shortly
15 region, to maintain hematopoietic stem cell repopulating ability through a miR-675-Igf1r signaling c
17 stem cell (HSC) subtypes with self-renewable repopulating ability, but with different haematopoietic
19 rs at the expense of reduced bone marrow HSC repopulating ability, thereby limiting potential therape
21 ulating activity, as Foxa3(-/-) HSC fails to repopulate ablated hosts efficiently, implicating for th
23 al human hematopoietic cells with short-term repopulating activity cells (STRCs) are needed to facili
24 otype ( approximately 10% HSCs with >6-month repopulating activity in immunodeficient mice) displayed
26 igration, niche retention, and hematopoietic repopulating activity of hematopoietic stem and progenit
28 -state in vivo hematopoiesis or on long-term repopulating activity of Wnt-deficient hematopoietic ste
29 mice to demonstrate that aged ECs impair the repopulating activity of young HSCs and impart a myeloid
30 ar, HSC number, cell cycle status, long-term repopulating activity, and self-renewal capacity were no
31 We validated that Foxa3 is required for HSC repopulating activity, as Foxa3(-/-) HSC fails to repopu
32 ciated with a marked loss of HSCs, long-term repopulating activity, HSC quiescence and common lymphoi
40 bset of horizontal basal cells (HBCs), which repopulate all microvillar cells and Bowman's glands dur
42 interactions and of microbial strategies to repopulate and survive in the soil are largely unexplore
43 n microglia were eliminated prior to RSD and repopulated and mice were subjected to acute stress, the
45 of phenotypically corrected HSPCs capable of repopulating and developing proliferation advantage in i
46 receptor antagonism (PLX5622) and allowed to repopulate, and responses to acute stress or immune chal
49 -cohort study, we evaluated the phenotype of repopulating B cells and its correlation with donor-spec
53 that in healthy allografts, protective ILC3s repopulate by 2-4 weeks postoperatively, but in rejectin
55 of the allograft, fall as the graft becomes repopulated by hematopoietic cells of the NOD2 mutant re
56 nocyte-depleted interfollicular epidermis is repopulated by melanocyte precursors from hair follicle
58 er times, the ablated skin was progressively repopulated by non-recombined Chk1-expressing cells and
60 progenitors, and exhibited reduced long-term repopulating capacity as well as hyper granulocyte-colon
61 Psigma substantially increased long-term HSC-repopulating capacity compared with BM cells from contro
62 owever, certain acinar subpopulations have a repopulating capacity during regeneration, raising the h
63 t derived xenografts we demonstrate that the repopulating capacity in normal mammary epithelial cells
66 TPsigma(-) cells substantially increased the repopulating capacity of human HSCs compared with CD34(+
67 ysical and chemical insults compromising the repopulating capacity of the epithelial stem cell compar
69 /-) LSK cells had an increased hematopoietic repopulating capacity with an altered cell differentiati
70 ant loss of quiescence and decline in serial repopulating capacity, but no substantial difference in
71 (-/-) HSCs exhibited decreased hematopoietic repopulating capacity, with skewed cell differentiation
76 ement membrane vs. non-basement membrane) on repopulating cell phenotype and function has important i
78 reatment resulted in a dramatic loss of SCID-repopulating cells (SRCs), treatment with OKT3 or UCHT1
79 nhanced clonal outputs from human short-term repopulating cells (STRCs) without affecting their engra
84 , including a 17-fold increase in short-term repopulating cells and a net 23-fold ex vivo expansion o
85 D34+ cells produced a greater number of SCID-repopulating cells and established multilineage hematopo
86 ene therapy since they efficiently transduce repopulating cells and may be safer than more commonly u
88 in lineage cells represent a major source of repopulating cells for reconstitution of the intraglomer
89 ction efficiency for long-term hematopoietic repopulating cells in humanized mice and rhesus macaques
90 ng hematopoiesis by giving rise to long-term repopulating cells in recipient mice with an unexpected
91 fficiently transduce and/or expand long-term repopulating cells in vivo are needed for treatment of d
92 ly posttransplant, and 3% to 5% in long-term repopulating cells over 6 months following HSPC transpla
95 to a pronounced increase in the frequency of repopulating cells, as assessed by extreme limiting dilu
96 g NOD.Cg-Prkdc(scid) IL2rg(tm1Wjl) /SzJ mice repopulating cells, induced by combination treatment.
103 in DNA-bound insulator proteins that rapidly repopulate chromatin as the bodies disassemble upon retu
111 ngineering of humanized intestinal grafts by repopulating decellularized rat intestinal matrix with h
114 nal stem/progenitor-like cells, were able to repopulate different nephron portions of renal extracell
115 d that Ly49G2(high) single-positive NK cells repopulated, displayed an activated phenotype, and were
116 viduals upon which natural selection acts to repopulate ecosystems with offspring, the proposed mater
118 inking the rates with which breeding females repopulated ecosystems, to the stability of ecosystems.
120 proliferative Lgr5(-) cells that are able to repopulate entire glands, including the base, upon deple
121 tial (DPsim(hi)) were enriched for long-term repopulating EpiSCs versus unfractionated cells (3.9- an
122 ing dilution transplantation and competitive repopulating experiments demonstrated a dramatic reducti
123 ellularized human liver cubic scaffolds were repopulated for up to 21 days using human cell lines hep
125 s) and establish that P-SSCs are a long-term repopulating, functionally distinct SSC subset responsib
127 ffect the homing and the number of long-term repopulating haematopoietic stem cells, haematopoietic s
128 ger age and persistence of higher VCN in the repopulating hematopoietic cells are associated with bet
134 scription factors that can amplify long-term repopulating hematopoietic stem cells in a controlled wa
135 en reported to identify functional long-term repopulating hematopoietic stem cells, and has been dete
136 tion of the edited CD34+ cells are long-term repopulating hematopoietic stem cells, demonstrating the
137 he maintenance of immunophenotypic long-term repopulating hematopoietic stem cells, suggesting that a
139 75% of cells in a highly enriched long-term repopulating HSC (LT-HSC) pool (Lin(-)Sca1(+)c-Kit(hi)CD
140 In contrast, long-term, but not short-term, repopulating HSC engraftment was impaired significantly,
141 opic miR-193b expression restricts long-term repopulating HSC expansion and blood reconstitution.
144 ined for a population enriched for long-term repopulating HSCs (LT-HSCs) versus their more differenti
146 rogeny, including closely related short-term repopulating HSCs (ST-HSCs) and fully differentiated lym
147 bient oxygen decreases recovery of long-term repopulating HSCs and increases progenitor cells, a phen
149 tro increased the recovery of both long-term repopulating HSCs and progenitor cells, and systemic adm
154 udies showed that the expansion of long-term repopulating HSCs was accompanied by synchronized expans
155 rtantly, upon macrophage depletion, no adult-repopulating HSCs were detected, thus implicating a role
156 lantation assays demonstrated that long-term repopulating HSCs were highly enriched within the gata2a
160 that the estimated minimum number of active, repopulating HSPCs (which ranged from 2000 to 50 000) wa
161 entiation and myofilament formation from the repopulated human multipotential cardiovascular progenit
164 reases the ability of the cells to long-term repopulate immunodeficient mice compared with equivalent
165 of CML cells, as well as their efficiency in repopulating immunodeficient mice, both in the presence
166 hitosan/gelatin composite, could transiently repopulate immunologically compromised mice skin to rega
168 ate that distinct stem/progenitor cell pools repopulate injured tissue depending on the extent of the
172 gesting a model wherein a parasite reservoir repopulates itself indefinitely, whereas some progeny ar
173 ensively after transplantation and therefore repopulate large parts of the recipient's hematopoietic
175 zed transcriptomic and epigenetic changes in repopulating liver macrophages following acute Kupffer c
176 ution returned to normal in 2 weeks, but the repopulated livers were unable to fully respond to drug-
177 in vitro, and markedly eliminated long-term repopulating LSCs and infiltrating blast cells, conferri
179 the GFP sorted cells failed to give rise to repopulated mammary glands in de-epithelialized recipien
180 tion prevented the behavioral decline in the repopulated mice, and it supported behavioral recovery i
187 served numbers of long-term HSCs, yet cannot repopulate nor sustain itself after transplantation agai
189 ith intact subunits in sucrose gradients and repopulate polysomes after a short starvation-induced tr
190 y less capable than more naive phenotypes of repopulating postdepletion, providing a potential mechan
197 f-2alpha-deficient HSCs and their ability to repopulate primary recipients, indicating that Hif-1alph
198 ain large numbers of mouse mitochondria that repopulate recipient mouse cells along with the injected
199 M niche has a role in modulating response of repopulating recipient cells toward AR-BP scaffolds for
200 via an unexpected proliferative response to repopulate residual tumours between chemotherapy cycles,
202 base edits could be produced in multilineage-repopulating self-renewing human HSCs with high frequenc
204 rsor cells proliferate and mature adipocytes repopulate skin wounds following inflammation and in par
205 t allow lingering immunosuppressive cells to repopulate small pockets of residual disease quickly.
207 erentiate into the less primitive short-term repopulating stem cells (ST-HSCs), which themselves prod
208 plexes preferentially expressed in long-term repopulating stem cells, is essential for adult hemopoie
210 y is associated with long-lasting effects on repopulated T cells and subsequent increased rates of in
211 veral studies have analyzed the phenotype of repopulated T-lymphocytes following alemtuzumab inductio
212 tor-transduced progenitor cells were able to repopulate the B-cell compartment with a normal distribu
214 plant, HSPCs need to expand substantially to repopulate the BM and replenish the peripheral blood cel
215 se progenitors can migrate out of the lungs, repopulate the bone marrow, completely reconstitute bloo
216 i; PAR(2) mobilization and de novo synthesis repopulate the cell surface with intact receptors and su
218 ed depletion rapidly enter the cell cycle to repopulate the cortex with altered spatial distribution.
219 buffering it to a level such that Zn(2+) can repopulate the defective binding site, but how it accomp
223 estigated whether cells of renin lineage can repopulate the glomerulus after podocyte injury and serv
226 epatic stem/progenitor cells can effectively repopulate the liver with advanced fibrosis/cirrhosis.
227 planted in vivo into wild-type stroma, fully repopulate the mammary gland fat pad, undergo unperturbe
229 urther, we demonstrate that the B cells that repopulate the MZ in aged bumble mice were distinct from
231 In chronic infection, HIV-1 escape mutants repopulate the plasma, and V3 and CD4bs nAbs emerge that
232 tic cell transplantation (HCT) is applied to repopulate the recipient myeloid compartment, including
234 endothelial cell progenitor cells (BM SPCs) repopulate the sinusoid as liver sinusoidal endothelial
235 ith reduced capacity to repair myofibers and repopulate the stem cell reservoir in vivo following tra
237 n may allow them to survive chemotherapy and repopulate the tumor after exposure to chemotherapeutics
238 with the exclusive ability to self-renew and repopulate the tumor and have been reported to be less s
239 t reservoir of mutant cells that can expand, repopulate the tumor, and result in the rapid emergence
243 rescued as newly generated immature neurons repopulated the granule cell layer upon termination of t
245 rred in a hematopoietic stem cell (HSC) that repopulated the myeloid but not the lymphoid lineage.
246 oke patients without tPA treatment gradually repopulated the numbers of circulating regulatory T cell
247 ctive B cells that had escaped depletion and repopulated the periphery through homeostatic expansion.
249 ours after injection of dimethylnitrosamine, repopulated the sinusoid as LSECs and reduced liver inju
251 othelial cells, and these T-cell progenitors repopulated the thymus and differentiated into mature T-
252 pulation selected from a population of cells repopulated the whole original basin of attraction withi
253 A very limited number of HSC clones (<10) repopulated the xenografted thymus, with further restric
255 lar triplet-state 'reservoir' that thermally repopulates the photoluminescent state of CdSe through e
259 hlight an ERG-regulated mechanism capable of repopulating the parent tumor through the transient gene
260 ation of functional pulmonary vasculature by repopulating the vascular compartment of decellularized
262 st for extremely long periods of time and to repopulate their own pool size through homeostatic self-
263 seeks to rehabilitate degraded ecosystems by repopulating them with large animals, thereby re-establi
267 s in blood after cessation of therapy, which repopulated tissues throughout the body; (b) that multip
268 -) mice in which the peripheral T cells were repopulated to a normal level by syngeneic bone marrow t
271 arbon flow direction in stem-like cells that repopulate tumors (tumor-repopulating cells (TRCs)).
272 expression enabled prostate cancer cells to repopulate tumors in orthotopic and heterotopic tissues.
274 ble for maintaining the capacity of HSPCs to repopulate under steady-state conditions, by activating
275 nstrated a dramatic reduction of competitive repopulating units and progressive decline in hematopoie
276 erial transplantation of long-term epidermal repopulating units derived from CD133(+) and CD133(+)Del
277 he potential of hematopoietic progenitors to repopulate upon adoptive transfer or after 5-fluorouraci
278 onditions, Cdk6(-/-) HSCs do not efficiently repopulate upon competitive transplantation, and Cdk6-de
280 ng of a decellularized lung scaffold that is repopulated with a patient's own cells could provide des
281 ver/thymus humanized mice, lung implants are repopulated with autologous human hematopoietic cells.
282 nt phenomenon allows for the construct to be repopulated with cells and to be connected to the blood
284 G mice backcrossed to the NOD background and repopulated with huHeps and human red blood cells suppor
287 re combined immunodeficient mice with livers repopulated with human hepatocytes (humanized livers).
288 plicating and in mice whose livers have been repopulated with human hepatocytes and infected with HBV
289 hat homozygous PIRF mouse livers are readily repopulated with human hepatocytes, and when the murine
293 n regions of CD11b-HSVTK transgenic mice are repopulated with new Iba-1-positive cells within 2 wk.
294 the nonobese diabetic (FRGN) background were repopulated with primary human hepatocytes from differen
295 Once in the body, these biomaterials are repopulated with somatic cells of various phenotypes who
296 sing a decellularized deceased donor trachea repopulated with the recipient's respiratory epithelium
298 that the microglia-depleted brain completely repopulates with new microglia within 1 week of inhibito
299 as in cartilage injured by blunt impact were repopulated within 7-14 days by cells that appeared to m
300 eveals that re-epithelializing keratinocytes repopulate wounds by TGF-beta- and integrin-dependent la