ライフサイエンスコーパス: repopulating

1 vitro and show strikingly increased in vivo repopulating abilities after single or sequential bone m

2 In BALB/cByJ (BALB) mice, repopulating abilities decline with age; DR ameliorates

3 6J (B6) and (BALB x B6) F1 hybrid (F1) mice, repopulating abilities increase with age; DR maintains t

4 on of murine HSPCs with short- and long-term repopulating abilities.

5 ic grafts mobilized with NSAIDs had superior repopulating ability and long-term engraftment.

6 to cytoablative stress, and exhibit superior repopulating ability and self-renewal upon serial transp

7 on display decreased frequency and defective repopulating ability as well as decreased lymphoid but i

8 of its rich content of cells with sustained repopulating ability in spite of an apparent deficiency

9 stem cells (HSCs) had decreased multilineage repopulating ability in vivo compared with WT controls i

10 A precise definition of the repopulating ability is needed to define which HSC subpo

11 its and progressive decline in hematopoietic repopulating ability of double-knockout (dKO) HSCs.

12 empol treatment did not adversely affect the repopulating ability of FA hematopoietic stem cells.

13 he influence of Flt3 expression on long-term repopulating ability of HSC subpopulations.

14 PC numbers but had only minor effects on the repopulating ability of HSCs.

15 ser extent HIF-1alpha, impedes the long-term repopulating ability of human CD34(+) umbilical cord blo

16 g dilution analysis, to assess the long-term repopulating ability of putative murine EpiSC population

17 The self-renewal and long-term repopulating ability of these cells was shown in serial-

18 ipients significantly impaired the long-term repopulating ability of transplanted mouse HSCs shortly

19 marrow function results from a major loss in repopulating ability per HSC.

20 region, to maintain hematopoietic stem cell repopulating ability through a miR-675-Igf1r signaling c

21 xpression of which in ESCs confers long-term repopulating ability to ESC-derived HSCs.

22 , DR increases or maintains increased marrow repopulating ability with age in the 3 different genotyp

23 n 8-fold reduction in multilineage long-term repopulating ability, a defect not seen in marrow cells

24 olling the balance between proliferation and repopulating ability, a finding of importance in clinica

25 ex differences were noted in HSC competitive repopulating ability, but not HPC numbers, in TIP110(TG)

26 stem cell (HSC) subtypes with self-renewable repopulating ability, but with different haematopoietic

27 Likely underlying the increased repopulating ability, FOXP3 expressing HSC showed signif

28 a p38 MAPK inhibitor significantly increased repopulating ability, supporting an integral role of p38

29 rs at the expense of reduced bone marrow HSC repopulating ability, thereby limiting potential therape

30 y for keratinocyte stem cells with long-term repopulating ability.

31 ative signals, can lead to exhaustion of HSC repopulating ability.

32 ions into immunodeficient mice to test their repopulating ability.

33 Aging dramatically reduced HSC in vivo-repopulating activity and lymphoid potential while incre

34 al human hematopoietic cells with short-term repopulating activity cells (STRCs) are needed to facili

35 otype ( approximately 10% HSCs with >6-month repopulating activity in immunodeficient mice) displayed

36 SPCs exhibit testicular repopulating activity in vivo and maintain the ability i

37 rial replating in vitro and long-term serial repopulating activity in vivo.

38 Functionally, the repopulating activity of Fancc(-/-) stem cells from reco

39 igration, niche retention, and hematopoietic repopulating activity of hematopoietic stem and progenit

40 lantations showed no change in the long-term repopulating activity of HSCs from mice exposed to recom

41 activity, its expression is required for the repopulating activity of human HSCs.

42 a microenvironmental defect that reduces the repopulating activity of wild-type HSCs.

43 -state in vivo hematopoiesis or on long-term repopulating activity of Wnt-deficient hematopoietic ste

44 mice to demonstrate that aged ECs impair the repopulating activity of young HSCs and impart a myeloid

45 eficient bone marrow had defective long-term repopulating activity that correlated with increased cel

46 creased endogenous competitive long-term HSC repopulating activity, and permitted efficient and durab

47 ar, HSC number, cell cycle status, long-term repopulating activity, and self-renewal capacity were no

48 We validated that Foxa3 is required for HSC repopulating activity, as Foxa3(-/-) HSC fails to repopu

49 t 1 in 65 000 zebrafish marrow cells contain repopulating activity, consistent with mammalian HSC fre

50 ciated with a marked loss of HSCs, long-term repopulating activity, HSC quiescence and common lymphoi

51 (HSCs) in older mice have decreased per-cell repopulating activity, self-renewal and homing abilities

52 cells results in a modest loss of long-term repopulating activity.

53 s short- and long-term in vivo hematopoietic repopulating activity.

54 ll growth and a loss of short- and long-term repopulating activity.

55 enhanced frequency, competence and long-term repopulating activity.

56 n 1/100th of the infused cells had long-term repopulating activity.

57 th both short-term and long-term bone marrow repopulating activity.

58 expression of Bmi-1 and enhanced competitive repopulating activity.

59 The expanded BM showed a distinct repopulating advantage when tested in serial competitive

60 d robust self-renewal capacity and exhibited repopulating advantages over wild-type HSCs.

61 of phenotypically corrected HSPCs capable of repopulating and developing proliferation advantage in i

62 mbers in culture, as measured in competitive repopulating assays.

63 -cohort study, we evaluated the phenotype of repopulating B cells and its correlation with donor-spec

64 The characteristics of the repopulating B cells are currently unknown.

65 We show here that repopulating bone marrow cells in certain mouse strains

66 pool, and elevates short-term and long-term repopulating capabilities, leading to the development of

67 elevated Notch signaling and reduced mammary repopulating capability upon transplantation.

68 progenitors, and exhibited reduced long-term repopulating capacity as well as hyper granulocyte-colon

69 Psigma substantially increased long-term HSC-repopulating capacity compared with BM cells from contro

70 owever, certain acinar subpopulations have a repopulating capacity during regeneration, raising the h

71 t derived xenografts we demonstrate that the repopulating capacity in normal mammary epithelial cells

72 Conversely, young ECs restored the repopulating capacity of aged HSCs but were unable to re

73 quiescence of dormant HSCs and the long-term repopulating capacity of HSC.

74 TPsigma(-) cells substantially increased the repopulating capacity of human HSCs compared with CD34(+

75 ysical and chemical insults compromising the repopulating capacity of the epithelial stem cell compar

76 -derived stem cells demonstrate a diminished repopulating capacity relative to that of purified bone

77 Furthermore, long-term repopulating capacity was also present in a compartment

78 /-) LSK cells had an increased hematopoietic repopulating capacity with an altered cell differentiati

79 ant loss of quiescence and decline in serial repopulating capacity, but no substantial difference in

80 (-/-) HSCs exhibited decreased hematopoietic repopulating capacity, with skewed cell differentiation

81 lation with severe combined immunodeficiency-repopulating capacity.

82 rly demonstrate the necessity of Shp2 in HSC repopulating capacity.

83 that BCR-ABL(+) cells had long-term in vivo repopulating capacity.

84 , greater competence, and enhanced long-term repopulating capacity.

85 elf-renewal and a severe loss of competitive repopulating capacity.

86 tem cells with enhanced homing and long-term repopulating capacity.

87 Attenuation in the extent of acute damage by repopulating cardiomyocytes and vessels decreased signif

88 Extracardiac progenitor cells are capable of repopulating cardiomyocytes at very low levels in the hu

89 Repopulating CD4+ but not CD8+ T cells significantly dim

90 liferation, resulting in increased long-term repopulating cell (LTRC) and competitive repopulating un

91 human SCID (severe combined immunodeficient) repopulating cell (SRC) transduction 3- to 4-fold, resul

92 eased severe combined immunodeficient (SCID)-repopulating cell counts in culture, compared to input a

93 were those in the CD34(-) Flt3R(-) long-term repopulating cell fraction.

94 ement membrane vs. non-basement membrane) on repopulating cell phenotype and function has important i

95 articularly in the most primitive, long-term repopulating cell population.

96 achieved, neither Notch1 nor Notch2 affected repopulating cell self-renewal.

97 human severe combined immunodeficient (SCID)-repopulating cells (SRCs) by transplantation into the no

98 both PMF HPCs, short-term and long-term SCID repopulating cells (SRCs), are JAK2V617F(+) and that JAK

99 reatment resulted in a dramatic loss of SCID-repopulating cells (SRCs), treatment with OKT3 or UCHT1

100 to mobilize murine LTR cells and human SCID repopulating cells (SRCs).

101 etic/severe combined immunodeficiency (SCID)-repopulating cells (SRCs).

102 nhanced clonal outputs from human short-term repopulating cells (STRCs) without affecting their engra

103 Tumour-repopulating cells (TRCs) are a self-renewing, tumorigen

104 Tumor-repopulating cells (TRCs) are cancer stem cell (CSC)-lik

105 tem-like cells that repopulate tumors (tumor-repopulating cells (TRCs)).

106 Recently we have shown that tumor-repopulating cells (TRCs), a highly tumorigenic subpopul

107 , including a 17-fold increase in short-term repopulating cells and a net 23-fold ex vivo expansion o

108 D34+ cells produced a greater number of SCID-repopulating cells and established multilineage hematopo

109 al pitfall of antibody-mediated clearance of repopulating cells and is important for any groups worki

110 ene therapy since they efficiently transduce repopulating cells and may be safer than more commonly u

111 Human repopulating cells are thought to express CD34 and lack

112 creasingly used to assay human hematopoietic repopulating cells as well as leukemia-initiating cells.

113 0-fold increase in the frequency of NOD/SCID repopulating cells compared with CD133+Lin- cells, sugge

114 d in long-term culture, initiating cells and repopulating cells compared with controls.

115 in lineage cells represent a major source of repopulating cells for reconstitution of the intraglomer

116 id markers, are expressed on human long-term repopulating cells from cord blood and bone marrow.

117 red lentiviral transduction of hematopoietic repopulating cells from either stem cell factor (SCF)- a

118 the cell-surface phenotype of hematopoietic repopulating cells from murine yolk sac, aorta-gonad-mes

119 ction efficiency for long-term hematopoietic repopulating cells in humanized mice and rhesus macaques

120 ng hematopoiesis by giving rise to long-term repopulating cells in recipient mice with an unexpected

121 vectors to transduce long-term hematopoietic repopulating cells in the dog, a clinically relevant lar

122 fficiently transduce and/or expand long-term repopulating cells in vivo are needed for treatment of d

123 ly posttransplant, and 3% to 5% in long-term repopulating cells over 6 months following HSPC transpla

124 CM niche is capable of directing behavior of repopulating cells remains relatively unexplored.

125 the perivascular niche, where proposed tumor-repopulating cells reside.

126 proximately 3.5% to 33% in myeloid long-term repopulating cells resulting in a functional cure.

127 transduction of canine CD34(+) hematopoietic repopulating cells using a very short, 18-hour transduct

128 efficient lentiviral transduction of canine repopulating cells using an overnight transduction proto

129 tailed macaque (Macaca nemestrina) long-term repopulating cells using VSV-G-pseudotyped HIV-based len

130 Furthermore, enhanced generation of NOD/SCID repopulating cells was seen following culture with lower

131 resence of DL yielded enhanced generation of repopulating cells with higher levels of engraftment of

132 in a multilineage increase in gene-modified repopulating cells with marking levels of greater than 9

133 ry, they efficiently transduce hematopoietic repopulating cells, and self-inactivating (SIN) designs

134 to a pronounced increase in the frequency of repopulating cells, as assessed by extreme limiting dilu

135 betic/severe combined immunodeficiency mouse repopulating cells, compared with day 0 CD34(+)CD38(-)li

136 g NOD.Cg-Prkdc(scid) IL2rg(tm1Wjl) /SzJ mice repopulating cells, induced by combination treatment.

137 need for caution in genetic manipulation of repopulating cells, particularly when the transgene migh

138 Hematopoietic repopulating cells, red blood cells, and T cells have re

139 to the expansion of CD34(+) cells and marrow-repopulating cells, treatment of IM CD34(+) cells result

140 f BIO5192 and plerixafor mobilized long-term repopulating cells, which successfully engraft and expan

141 in vivo expansion of corrected hematopoietic repopulating cells.

142 contained normal multilineage hematopoietic repopulating cells.

143 fficient at transducing rhesus hematopoietic repopulating cells.

144 types in vitro, and (5) transplantable liver-repopulating cells.

145 atopoietic stem cell numbers or expansion of repopulating cells.

146 lizumab-treated subjects also contained SCID-repopulating cells.

147 transduction of multipotential hematopoietic repopulating cells.

148 ve advantage of corrected FA-A hematopoietic repopulating cells.

149 the basal compartment, which harbors mammary repopulating cells.

150 action contain both short-term and long-term repopulating cells.

151 ing cells, and both long-term and short-term repopulating cells.

152 t identifies both murine and human long-term repopulating cells.

153 n stable myeloid-B-T multilineage, long-term repopulating clones.

154 mouse, opening a door to the possibility of repopulating damaged sensory epithelia in humans.

155 Here we create heart constructs by repopulating decellularized mouse hearts with human indu

156 ngineering of humanized intestinal grafts by repopulating decellularized rat intestinal matrix with h

157 injured epithelia promotes BMP7 signaling in repopulating, dedifferentiated epithelia.

158 KLF7, and loss of CDKN1A does not rescue the repopulating defect.

159 ound thrombocytopenia and a severe stem cell-repopulating defect.

160 Notably, in the absence of p16INK4a, HSC repopulating defects and apoptosis were mitigated, impro

161 re-HSCs capable of developing into long-term repopulating definitive HSCs.

162 an undergo reprogramming to become long-term repopulating epidermal progenitors following wounding.

163 spensable for the maintenance of established repopulating epidermal stem cells and for the differenti

164 tial (DPsim(hi)) were enriched for long-term repopulating EpiSCs versus unfractionated cells (3.9- an

165 ing dilution transplantation and competitive repopulating experiments demonstrated a dramatic reducti

166 Competitive repopulating experiments show that SCF(+)DLK(+) cells su

167 a novel purification of HSCs with long-term repopulating function and may be considered an alternati

168 types (CD34+CD38-) and demonstrated enhanced repopulating function in recipients of serial, secondary

169 ells, a phenotype previously associated with repopulating function.

170 gh ALDH activity further purified cells with repopulating function.

171 s) and establish that P-SSCs are a long-term repopulating, functionally distinct SSC subset responsib

172 However, its application to long-term repopulating haematopoietic stem cells (HSCs) has remain

173 ffect the homing and the number of long-term repopulating haematopoietic stem cells, haematopoietic s

174 ger age and persistence of higher VCN in the repopulating hematopoietic cells are associated with bet

175 The first adult-repopulating hematopoietic stem cells (HSCs) emerge in t

176 support the ex vivo expansion of short-term repopulating hematopoietic stem cells (HSCs), the ex viv

177 ic progenitor cells (HPCs) at the expense of repopulating hematopoietic stem cells (HSCs).

178 ent of CD34(+) cells that contains long-term repopulating hematopoietic stem cells (HSCs).

179 Multipotent long-term repopulating hematopoietic stem cells (LT-HSCs) can self

180 Retention of long-term repopulating hematopoietic stem cells (LT-HSCs) in the b

181 scription factors that can amplify long-term repopulating hematopoietic stem cells in a controlled wa

182 en reported to identify functional long-term repopulating hematopoietic stem cells, and has been dete

183 tion of the edited CD34+ cells are long-term repopulating hematopoietic stem cells, demonstrating the

184 he maintenance of immunophenotypic long-term repopulating hematopoietic stem cells, suggesting that a

185 rial transplantation, hallmarks of long-term repopulating hematopoietic stem cells.

186 d colonizes the liver by E10.5, before adult-repopulating hematopoietic stem cells.

187 bility of AMD3100 to mobilize true long-term repopulating hematopoietic stem cells.

188 A delay in functional maturity of repopulating HLA-specific B cells, and in particular tho

189 ying the relative frequencies of hundreds of repopulating HPSC clones in a nonhuman primate.

190 75% of cells in a highly enriched long-term repopulating HSC (LT-HSC) pool (Lin(-)Sca1(+)c-Kit(hi)CD

191 In contrast, long-term, but not short-term, repopulating HSC engraftment was impaired significantly,

192 opic miR-193b expression restricts long-term repopulating HSC expansion and blood reconstitution.

193 rophin caused a marked increase in long-term repopulating HSC numbers in culture, as measured in comp

194 xpanded 3-fold and maintained this long-term repopulating HSC phenotype.

195 IFN-gamma is sufficient to promote long-term repopulating HSC proliferation in vivo; furthermore, HSC

196 However, long-term repopulating HSCs (LT-HSCs) persist when Runx1 is condit

197 ined for a population enriched for long-term repopulating HSCs (LT-HSCs) versus their more differenti

198 sis and detected Id1 expression in long-term repopulating HSCs (LT-HSCs).

199 lays a critical role in preserving long-term repopulating HSCs (LT-HSCs).

200 rogeny, including closely related short-term repopulating HSCs (ST-HSCs) and fully differentiated lym

201 Similar to freshly isolated HSCs, repopulating HSCs after culture were positive for the st

202 bient oxygen decreases recovery of long-term repopulating HSCs and increases progenitor cells, a phen

203 l cells results in a deficiency of long-term repopulating HSCs and intra-aortic cluster cells.

204 tro increased the recovery of both long-term repopulating HSCs and progenitor cells, and systemic adm

205 ermediate blood progenitors but of long-term repopulating HSCs as well.

206 d promotes in vitro propagation of long-term repopulating HSCs by preventing differentiation.

207 A clonal analysis of repopulating HSCs demonstrates that lymphoid-biased HSCs

208 ession and is required to generate long-term repopulating HSCs in the AGM.

209 HSC cycling and reduces functional long-term repopulating HSCs in the bone marrow.

210 ant and increased the frequency of long-term repopulating HSCs present in murine bone marrow after li

211 n, that an increased proportion of long-term repopulating HSCs proliferate during M. avium infection,

212 Long-term repopulating HSCs reside in several, perhaps overlapping

213 udies showed that the expansion of long-term repopulating HSCs was accompanied by synchronized expans

214 Thus, the full repertoire of repopulating HSCs was covered.

215 nitor cells, although selection of long-term repopulating HSCs was not seen.

216 rtantly, upon macrophage depletion, no adult-repopulating HSCs were detected, thus implicating a role

217 lantation assays demonstrated that long-term repopulating HSCs were highly enriched within the gata2a

218 t NPM promotes the self-renewal of long term repopulating HSCs while attenuated their commitment to m

219 self-renewal, the highest being on long-term repopulating HSCs, and decreases with differentiation, w

220 ls (HSCs), the ex vivo survival of long-term repopulating HSCs, and the prolonged in vivo expansion o

221 egress of murine HSPCs, including long-term repopulating HSCs, over mature leukocytes.

222 progenitor cells (MPPs) as well as long-term repopulating HSCs, while delaying myeloid differentiatio

223 ecreased ability to support the expansion of repopulating HSCs.

224 ecreased ability to support the expansion of repopulating HSCs.

225 antation confirmed transduction of long-term repopulating HSCs.

226 - KSL fraction, which is highly enriched for repopulating HSCs.

227 sulted in an approximate 8-fold expansion of repopulating HSCs.

228 a net 23-fold ex vivo expansion of long-term repopulating HSCs.

229 ture that characterizes functional long-term repopulating HSCs.

230 that the estimated minimum number of active, repopulating HSPCs (which ranged from 2000 to 50 000) wa

231 ts an approximately 20-fold net expansion of repopulating human cord blood HSCs, a number potentially

232 SDS scaffolds were toxic to repopulating human mesenchymal stem cells (hMSC).

233 of CML cells, as well as their efficiency in repopulating immunodeficient mice, both in the presence

234 alysis aimed at revealing their identity and repopulating in vivo capacity.

235 CAM(+) cells are true progenitors capable of repopulating injured rat liver.

236 Interestingly, repopulating irradiated control mice with bone marrow de

237 staining revealed approximately 5% to 10% of repopulating liver cells expressing human alpha1-antitry

238 These factors in turn reprogrammed the repopulating liver macrophage enhancer landscape to conv

239 zed transcriptomic and epigenetic changes in repopulating liver macrophages following acute Kupffer c

240 in vitro, and markedly eliminated long-term repopulating LSCs and infiltrating blast cells, conferri

241 ession on large vessel endothelial cells and repopulating LSECs.

242 Long-term repopulating (LT) hematopoietic stem cells (HSCs) are th

243 AMD3100 also mobilized murine long-term repopulating (LTR) cells that engrafted primary and seco

244 for the maintenance of established long-term repopulating (LTR) HSCs in the adult.

245 es expansion of multipotent cells capable of repopulating lymphoid and megakaryocyte lineages, which

246 in a transplantable, premalignant, long-term repopulating, MDS-initiating cell.

247 The beneficial effects of these repopulating microglia are critically dependent on inter

248 Using a long-term repopulating model, they demonstrate that epidermal stem

249 Extracardiac progenitor cells are capable of repopulating most major cell types in the heart, but the

250 , dendritic cells, and monocytes/macrophages repopulating mouse tissues.

251 Immunophenotypic analysis showed that repopulating mucosal CD4+ T cells were predominantly of

252 enhanced the rate of formation of short-term repopulating multipotential progenitor cells (MPPs) as w

253 port the expansion of human cells capable of repopulating non-obese diabetic/severe combined immunode

254 t stem cell that gives rise to the long-term repopulating of hematopoietic stem cells, mesenchymal st

255 C is influenced by both short- and long-term repopulating populations and that Flt3 expression may be

256 y less capable than more naive phenotypes of repopulating postdepletion, providing a potential mechan

257 1 regulation of HSC quiescence and long-term repopulating potential and hematopoietic lineage develop

258 Deletion of Slug enhances HSC repopulating potential but not its homing and differenti

259 enance of hematopoietic functions, including repopulating potential by up-regulating Notch-mediated s

260 g deficiency increases HSC proliferation and repopulating potential in vivo after myelosuppression an

261 f the HSC pool and a marked reduction of HSC repopulating potential in vivo.

262 CFU expansion and marrow repopulating potential of cultured Lineage(-)Sca-1(+)CD1

263 By contrast, the clonogenic and repopulating potential of normal hematopoietic stem and

264 macological inhibition of EZH2 decreases the repopulating potential of p53 mutant HSPCs.

265 r cell cycle greatly impaired the short-term repopulating potential of SKP2 null HSC and their abilit

266 d progressive depletion, defective long-term repopulating potential, and hematopoietic lineage develo

267 adult murine liver that possess potent blood-repopulating potential, approaching that of BM HSCs.

268 irradiated recipients, and enhanced in vivo repopulating potential.

269 bers of cell divisions retained their marrow repopulating potential.

270 isions in vitro while retaining their marrow-repopulating potential.

271 ng to aggressive lymphomas with an increased repopulating potential.

272 had a severely reduced competitive long-term repopulating potential.

273 ny of these CB CD34+ cells lose their marrow-repopulating potential.

274 M niche has a role in modulating response of repopulating recipient cells toward AR-BP scaffolds for

275 tem cells as a therapeutic strategy aimed at repopulating regions of bowel, where enteric neurones ar

276 base edits could be produced in multilineage-repopulating self-renewing human HSCs with high frequenc

277 icient mice reflecting recovery of long-term repopulating, self-renewing HSCs.

278 dose, suggesting involvement of a short-term repopulating stem cell or an early myeloid progenitor.

279 erentiate into the less primitive short-term repopulating stem cells (ST-HSCs), which themselves prod

280 plexes preferentially expressed in long-term repopulating stem cells, is essential for adult hemopoie

281 sistent long-term engraftment of isogenic WT repopulating stem cells.

282 ed myeloerythroid progenitors and functional repopulating stem cells.

283 6 weeks and efficient targeting of long-term repopulating stem cells.

284 gorously self-renew, expanding in number and repopulating the host muscle with new satellite cells.

285 The procedure is aimed at ablating and repopulating the immune repertoire by sequentially mobil

286 disassembling sarcomeres, proliferating, and repopulating the injured area remain unclear.

287 Recently, it has been suggested that cells repopulating the ischemically injured tubule derive from

288 y, and the residual symbionts began growing, repopulating the light organ.

289 recently described a regulatable system for repopulating the liver of immunodeficient mice (specific

290 ells remained in the circulation rather than repopulating the mucosa of the small intestine.

291 s from fetal liver that are fully capable of repopulating the normal adult liver.

292 hlight an ERG-regulated mechanism capable of repopulating the parent tumor through the transient gene

293 ets displayed a specific growth advantage in repopulating the spleen in competitive replacement bone

294 ation of functional pulmonary vasculature by repopulating the vascular compartment of decellularized

295 s as the primary source of endothelial cells repopulating the vessel wall following injury.

296 seeks to rehabilitate degraded ecosystems by repopulating them with large animals, thereby re-establi

297 erm repopulating cell (LTRC) and competitive repopulating unit (CRU) frequency.

298 nstrated a dramatic reduction of competitive repopulating units and progressive decline in hematopoie

299 erial transplantation of long-term epidermal repopulating units derived from CD133(+) and CD133(+)Del

300 We measured at the clonal level repopulating waves, populations' sizes and dynamics, act