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1 l cultures, the entire flavonoid pathway was repressed.
5 phage lambda expressing a programmable dCas9 represses a targeted E. coli gene in the mammalian gut.
6 studies, SHP inhibited miR-210 expression by repressing a transcriptional activator, Kruppel-like fac
8 L-5, a major ILC2 product, was sufficient to repress aging-associated neuroinflammation and alleviate
12 e loss of epidermal homeostasis and uniquely repressed an IFN-inducible coexpression module activated
14 al polysomes, here we report translationally repressed and derepressed mRNA isoforms during neocortic
15 become quiescent, endothelial glycolysis is repressed, and GLUT1 expression increases in a Notch-dep
16 ith MAT2alpha to promote DNA methylation and represses antioxidant and anti-inflammatory transcriptio
18 s Salmonella enterica and Vibrio cholerae by repressing AraC-type transcriptional regulators in patho
19 1 or MMP12 suppression in ALI-inflicted mice repress arterial stress and brake MMP12 release by trans
21 gely a consequence of the ability of ClpS to repress ATP hydrolysis by ClpA, but several lines of evi
22 lic-di-GMP with FlrC(C) Excess cyclic-di-GMP repressed ATPase activity of FlrC(C) through destabiliza
25 t of Tcfs, whereas on other enhancers, Sox17 represses beta-catenin/Tcf-mediated transcription to spa
26 ntiated state and prevents renal fibrosis by repressing beta-catenin activity, whereas KCTD1 deficien
29 ruitment of polycomb repressive complex 2 to repress branching-inhibitory genes via H3K27me3 modifica
31 main conjugation promoter, Pc, is by default repressed by a regulator RcopLS20 involving DNA looping.
32 e potent than RA in rescuing RA/RAR activity repressed by albumin, high glucose, angiotensin II, aldo
33 ails in mutants for Pentagone (pent), a gene repressed by Dpp that encodes a diffusible protein that
35 s Cbfa2t3 and Jdp2 The large number of genes repressed by gain of E protein function leads to the dow
36 ion of the licT-blgPB operon was found to be repressed by glucose and induced by the beta-glucoside s
37 and lack oligodendroglial programs, actively repressed by GSX2/DLX-mediated cell fate specification.
38 mitochondrial fatty acid (FA) transport, is repressed by hypoxia-inducible factors (HIFs), reducing
40 nes that are activated by MYC:MAX dimers are repressed by MNT:MAX dimers, MNT is considered a transcr
44 his +4 antral SC is Notch1(low)/ Numb(+) and repressed by signaling from gastrin-expressing endocrine
45 In euchromatin, a set of conserved genes is repressed by Su(var)2-10/SetDB1-induced H3K9 trimethylat
46 the female lethality of FL3#2 was partially repressed by supplying tetracycline to the parental gene
47 ts that CALCOCO1 and ZC3H10 are target genes repressed by the HOTAIR regulatory element and that both
48 ions revealed that spxA1 transcription is co-repressed by the metalloregulators PerR and SloR while s
49 components of heterochromatin are themselves repressed by this pathway, providing a negative feedback
50 e-acquisition genes pho1, pho84 and tgp1 are repressed by upstream lncRNAs and are sensitive to chang
51 cer cells, in which hMATE1 is epigenetically repressed, can be sensitized to compound 1 by priming th
53 otects against metabolic diseases and aging, represses cancer growth and improves cancer therapy.
56 creased expression of miR-1185-1 and further repressed CD24 translation and colorectal cancer stemnes
59 Even when UL128-131 was transcriptionally repressed, cell-to-cell spread of ME was still more effi
60 YAP was proposed to inhibit skeletal size by repressing chondrocyte proliferation and differentiation
62 domain clusters with a zonal organization of repressed chromatin domains in the interior and transcri
63 results strongly suggest that removal of the repressed chromatin flanking the GAA tract might contrib
67 uction AlgU (a sigma(E) orthologue) and AlgR repress CRISPR-Cas activity during planktonic and surfac
69 other alginate regulator(6), is triggered to repress CRISPR-Cas immunity upon surface association.
71 Mechanistically, the presence of 6mA could repress DNA binding and bending by mitochondrial transcr
72 Cdk1 activity during ESC differentiation de-represses Dot1l, thereby allowing coordinated expression
74 f lncRNAs, but not protein-coding mRNAs, are repressed during diet-induced obesity (DIO) and refeedin
75 ctive in quiescent oocytes invariably become repressed during meiotic re-entry, whereas transcripts r
78 nsferase Dot1l has an antifibrotic effect by repressing Edn1, which encodes endothelin 1 in the conne
79 rks that stabilize Treg cellular identity by repressing effector T cell transcriptional programs.
84 esulting from D14L signalling activation, de-represses essential symbiotic programmes and increases s
85 reated ER-positive breast cancer patients by repressing estrogen signaling and inducing cell death re
86 beta-insulin/IGF1 relay to target tissues to repress expression of catalases and other hydrogen perox
88 rofiling during reprogramming reveals CoREST represses expression of enzymes that degrade juvenile ho
89 subsequent modifier screen reveal that pdm3 represses expression of the synaptogenesis gene Msp300 t
90 hosphate (c-di-GMP) by posttranscriptionally repressing expression of crvA, a gene encoding an interm
91 ith wild-type EGFR (EGFR(WT)) to EGFR TKI by repressing expression of liver kinase B1 (LKB1), a maste
92 so restrains B cell access to T cell help by repressing expression of the T cell chemokines CCL3 and
94 silencing is genetically required by FCA to repress FLC Overall, our work provides insights into RNA
95 f-antigen: instead of becoming tolerized and repressed from secreting autoantibody, Pik3cd gain-of-fu
96 positively regulate plant salt tolerance by repressing GALS1 expression and beta-1,4-galactan accumu
97 Molecular analyses suggest that pi6 piRNAs repress gene expression by cleaving messenger RNAs encod
98 cate that cheRNAs may function to promote or repress gene expression in a context-dependent manner.
99 structure of DNA or RNA which can enhance or repress gene expression, yet the underlying molecular me
100 tivators such as enhancers, but regions that repress gene expression-silencers-have not been systemat
103 this study, we demonstrate that Ezh2, which represses gene expression through methylation of histone
104 cellular stress protection by activating or repressing gene transcription in response to protein mis
105 tion, Gcn2 phosphorylates eIF2alpha, thereby repressing general translation while enhancing translati
106 Additionally, a subset of PIF-activated, AHL-repressed genes are directly bound by both SOB3 and PIFs
107 ltiple histone marks: H3K27me3, a marker for repressed genes, and H3K4me1 and H3K4me3, which are indi
113 suggest that AP2 controls meristem arrest by repressing genes related to axillary bud dormancy in the
114 rocess, promoting cytokinin biosynthesis but repressing gibberellin production to condition a replica
115 previous in vitro studies have shown that Mn repressed GLAST and GLT-1 via activation of transcriptio
119 gion of SSX confers preferential affinity to repressed, H2AK119Ub-marked nucleosomes, underlying the
124 uce double-stranded RNA to activate RNAi and repress host gene expression, thereby altering bee physi
125 lize specific CNS abdominal neurons where de-repressed Hth compromises virgin behavior in BX-C miRNA
127 hat beta-glucan-induced innate immune memory represses IL-1beta-mediated inflammation and support its
128 , which indicated exclusion of metabolically repressed immune cells from the tumor-immune boundary.
129 scriptional activity and nuclear import were repressed in DeltaBbOhmm cells and affected by intracell
131 sis, FA and membrane lipid biosynthesis were repressed in GmLEC2a-OE but increased in GmWRI1b-OE hair
134 ission yeast phosphate homeostasis genes are repressed in phosphate-rich medium by transcription of u
137 catabolize less preferred carbon sources is repressed in the presence of a preferred carbon source.
138 e antiviral genes induced by type I IFNs are repressed in the presence of butyrate, resulting in incr
139 he control of a transcription factor that is repressed in the presence of the superior carbon source.
142 , HDAC3 operates in conjunction with KLF4 to repress inappropriate expression of Tgm1, Krt16, and Aqp
143 icient to rescue cell viability of autophagy-repressed infected monocytes, suggesting that autophagy
145 for the first time HIV-1 LTR model featuring repressed, intermediate, and activated LTR states is int
146 st that the ability of H-NS-like proteins to repress intragenic transcription is a universal function
147 is genes of V. cholerae c2-HDA significantly repressed invasion gene expression by Salmonella in the
149 regulation, that is the ability of a gene to repress its own synthesis, is the most abundant regulato
152 Y5) binds to the DEWAX promoter elements and represses its expression to promote the anthocyanin bios
153 cing temperature, binds the Kdm6b locus, and represses Kdm6b transcription, blocking the male pathway
155 ation by HPV16 E7 and PTPN14 CRISPR knockout repress keratinocyte differentiation-related genes.
160 TNBC cell invasion and metastatic growth by repressing MBNL1-directed splicing of ITGA6 Our findings
161 re, we identify a translational pathway that represses metabolism to safeguard genome integrity.
164 Here we show that repetitive DNA becomes de-repressed more rapidly in old male flies relative to fem
166 ophila AGO1 functions outside of the RISC to repress Myc transcription and inhibit developmental cell
169 ectly up-regulates skeletal muscle genes and represses non-muscle genes through affecting regional ep
170 1 co-distributed with c-MYC and specifically repressed nuclear-encoded mitochondrial and splicing-ass
172 putative binding sites in the HSV-1 genome, repress numerous viral genes spanning all three kinetic
174 that Mycl is expressed in immature cDC1s but repressed on maturation, concomitant with Mxd1 induction
176 directed to P granules to be translationally repressed, or do they accumulate there as a consequence
177 Our findings indicate that NLR signaling represses osmotic stress responses and that BON proteins
179 upting MDM2-p53 interaction and subsequently repressing p53 ubiquitination, whereas knockdown of RBM1
180 K1 is required by the BRAF-ERK1/2 pathway to repress PARK2 expression and promoter activity in melano
181 lectively, our results demonstrate that AHLs repress petiole growth by antagonizing PIF-mediated tran
182 forward genetic screen for mutations that de-repress Pho1 acid phosphatase expression in CTD-T4A cell
184 data, we propose a mechanism for how CsMAF1 represses Pol III transcription and how phosphorylation
186 sition transcription factor SLUG to directly repress pro-apoptotic BMF, limiting drug-induced apoptos
187 echanistically, miR-15a/16-1 translationally represses pro-angiogenic factors VEGFA, FGF2, and their
188 sis showed that ADAR1 suppression profoundly repressed proliferation, invasion, and migration in thyr
189 anslationally regulated targets USP3 and SCD repressed proliferation-revealing a dedicated tRNA-regul
190 hypothalamic arcuate nucleus and that MKRN3 repressed promoter activity of human KISS1 and TAC3, 2 k
191 ntegrity appeared compromised at a subset of repressed promoters, suggesting a source of cyclin C tha
192 ver, analogous experiments showed that SRRP1 represses psbA ribosome association in the dark, repress
193 ch LuxR serves as a counter-silencer at H-NS-repressed quorum sensing loci by disrupting H-NS nucleop
197 sm is linked to the microbiota's capacity to repress responses to the phytohormone abscisic acid in t
200 Also, inactivating the small RNA RybB which represses rluD led to faster persister resuscitation.
201 nal tests suggest that H gained its trichome-repressing role late in the history of eudicots and that
202 Knockdown of AMPKalpha1 or/and AMPKalpha2 repressed Rspos-induced inhibition on cholesterol synthe
204 cipates in the responses to biotic stress by repressing salicylic acid (SA) accumulation and SA-media
205 similar efficacy to the BET inhibitor JQ1 at repressing SE-dependent MYC expression and AML growth in
206 trated that PIFs accumulated in darkness and repressed seedling photomorphogenesis, and that PIFs lin
208 imultaneous targeting of these activated and repressed signaling pathways may be necessary to combat
209 reast cancer cohort, FGFR4-induced and FGFR4-repressed signatures each predicted overall survival.
213 C arrests NK maturation by transcriptionally repressing STAT1/2 and secretion of Type I Interferons (
215 lyses suggest that these topological changes repress stemness and invasion programs while inducing an
217 (i) manipulating antigen presentation, (ii) repressing T cell-activating costimulatory molecules, an
221 f canonical AUX/IAA proteins, which normally repress the activity of auxin response transcription fac
222 by developmental and reproductive cues that repress the activity of proteostasis-related pathways in
224 ealed that the HOXA5-9 transcription factors repress the Ealpha enhancer at early stages of T cell di
226 mpletely defined mechanisms, CovR/S and RocA repress the expression of more than a dozen immunomodula
227 ssing cells and that MNT-MAX dimers bind and repress the MNT promoter, an effect that depends on one
228 tures because of an inability to effectively repress the movement of specific mobile DNA elements tha
229 ith this observation, we show that ZBED2 can repress the pancreatic progenitor transcriptional progra
230 the light and vegetative shade and that they repress the rapid PIF-induced expression of PIF-DTGs tri
231 in planta, the majority of these regulators repress the transcription of genes encoding class A ARFs
232 of polycomb-repressive-complex 2 (PRC2), to repress the transcriptional program associated with nega
234 s of plant defense secondary metabolites and repressed the accumulation of proteins involved in photo
235 assays, ACh and non-hydrolysable ACh analogs repressed the expression of connexin43 and connexin45 he
236 ke factor 3 (KLF3), which, in turn, directly repressed the expression of the NF-kappaB family member
239 PRDM16 binds to cis-regulatory elements and represses the expression of region-specific neuronal dif
242 r binds ferrous iron, and the iron-bound Fur represses the genes encoding for iron uptake systems and
245 that P. infestans subverts host immunity by repressing the AS of positive regulators of plant immuni
246 rs of salicylic acid (SA)-mediated immunity, repressing the biosynthesis of SA in healthy plants.
247 nce of co-stimulation and do so, in part, by repressing the expression of BATF and, consequently, MYC
248 ate that AHL4 suppresses lipid catabolism by repressing the expression of specific genes involved in
253 functions not by scavenging H(2)O(2), but by repressing the nutrient signaling Ras-cAMP-PKA pathway a
256 ed repressor form to Zur box operator sites, repressing the transcription of zinc uptake transporters
257 a toxic gain of function in the cytoplasm by repressing the translation of mRNA at polyribosomes.
258 associated with some of these NLR genes and repress their expression likely through reducing the ace
262 eins, we show that ubiquitylation is tightly repressed throughout elongation by the Y-shaped DNA stru
263 or of macrophage pro-inflammatory responses, represses Toll-like receptor 3 and virus-induced express
264 n and mTORC1 effector that has been shown to repress TOP mRNA translation in a few specific cases.
265 des the transcript of TRAILR4, which in turn represses TRAILR4 expression and inhibits the aggressive
266 sue identified miR-203 as a matrix stiffness-repressed transcript that is downregulated by collagen d
267 d human intestinal organoids, MTG8 and MTG16 repress transcription in the earliest progenitor cells t
268 otifs, thereby serving to either activate or repress transcription of specific genes involved in nick
269 nregulation of the type I IFN pathway due to repressed transcription and lower chromatin accessibilit
276 site-dependent manner: Monomer Gsx2 binding represses transcription, whereas homodimer binding stimu
277 moves them from the translatable pool; these repressed transcripts are stabilized and stored until P-
279 all ORFs in 5' UTRs (upstream (u)ORFs) often repress translation of the canonical ORF within the same
280 of encoded FMRP, an RNA binding protein that represses translation of some of its target transcripts.
281 a single gene, Hairy (H), which is needed to repress trichome fate, underlies variation in trichome p
287 ion genes - pho1, pho84, and tgp1 - that are repressed under phosphate-replete conditions by 5' flank
291 by counteracting c-Myc and transcriptionally repressing vascular endothelial growth factor A (VEGFA)
292 fined that the microRNA-377 precursor, which represses Vegfa messenger RNA translation, is druggable
293 known whether host transcription factors can repress viral genes more proximately to promote latency
295 ompR overexpression in wild-type cells also repressed virulence through aphB We further show that om
299 esses psbA ribosome association in the dark, represses ycf1 ribosome association, and promotes accumu
300 activated by DUX and post-transcriptionally represses ZMYM2 and its partner LSD1, and ZMYM2 recruits