ライフサイエンスコーパス: repression

1 rbon sources is shut down, due to catabolite repression.

2 re generally associated with transcriptional repression.

3 p50 binding lacking p65 with transcriptional repression.

4 zed EZH2 and SOX2 activity, balancing toward repression.

5 their activity is primarily regulated by GLI repression.

6 rochromatin protein 1 (HP1) are hallmarks of repression.

7 d that is important for this transcriptional repression.

8 RNA and mitigate miR-21-mediated translation repression.

9 c imprinting and homeobox (Hox) gene cluster repression.

10 cus illustration of both gene activation and repression.

11 gulates alternative organ fates including by repression.

12 , E-cadherin, and HNF1alpha) and cause their repression.

13 genes, coinciding with their transcriptional repression.

14 sustains female fates independently of Dmrt1 repression.

15 sor complex to MERVL LTR for transcriptional repression.

16 H-PHD-CPL2 complex (BPC) for transcriptional repression.

17 y is required for tiRNA-mediated translation repression.

18 knock out or modulate through activation and repression.

19 SOR and MPP8 domains necessary for transgene repression.

20 while ARID1A binding is associated with gene repression.

21 dicating a common mechanism of translational repression.

22 encoding many proinflammatory proteins, was repression.

23 ons that are associated with transcriptional repression.

24 artially separated from its function in gene repression.

25 RNAs) to identify targets of transcriptional repression.

26 IC proteins that confer trans-activation or -repression.

27 nd the extent of the induced transcriptional repression.

28 ical for brain function, and transcriptional repression.

29 thelial cilia, implicating deficient pathway repression.

30 RNA and prevents miR-21-mediated translation repression.

31 n of the GLI2 promoter is necessary for GLI2 repression.

32 acterial histidine kinase and mediates T3SS1 repression.

33 that are a major contributor to translation repression.

34 stone modification that correlates with gene repression.

35 ey accumulate there as a consequence of this repression?

36 associated protein with death domain protein repression along with decreased T-cell infiltration.

37 rted to promote miRNA-mediated translational repression, amp1 did not prevent the translational repre

38 ostery can be manifested as a combination of repression and activation in multidomain proteins allowi

39 atenin signaling drives both widespread gene repression and activation.

40 In conclusion, type-2 cytokine-mediated gene repression and blockade of KC differentiation are multif

41 echanisms governing alternative lineage gene repression and commitment in lymphocytes are largely unk

42 domains of Gfi1, but not its transcriptional repression and DNA binding activities, were required for

43 lopment is accompanied by increased Polycomb repression and EZH2-mediated redistribution of H3K27me3

44 o identify the mechanism of Pumilio-mediated repression and find that it accelerates degradation of t

45 m responsible for SRF stabilization and KLF4 repression and is required for the establishment of the

46 a peripheral subdomain enforces stable gene repression and maintains heterochromatin in a heritable

47 arental-specific domains correlate with gene repression and participate in parentally biased gene exp

48 strategies were taken to eliminate ammonium repression and place nitrogenase expression under the co

49 pand our understanding of HSF1-mediated gene repression and provide key insights into HSF1 regulation

50 unit 8 (IntS8) is critical for transcription repression and required for association with protein pho

51 at hyperinsulinemia induces sirtuin1 (SIRT1) repression and stimulates NF-kappaB p65 nuclear transloc

52 where it is associated with transcriptional repression, and at CAG trinucleotides in embryonic stem

53 sis regulator nuclear receptor corepressor 2 repression, and chromatin immunoprecipitation assays ide

54 ast, ligand-induced corepressor-dependent NR repression appears to occur through structurally diverse

55 We discovered that both Cic-DNA binding and repression are rapidly reinstated in the absence of ERK

56 hibition of substrate binding and its ATPase repression are separable activities.

57 ies DNA-methylation-mediated transcriptional repression as a backup system for post-translational pro

58 he authors did not consider PAX7 target gene repression as a marker of FSHD progression.

59 These results implicate transcriptional repression as a means to deliver essential maternal tran

60 Moreover, they identified FBP1 repression as an important downstream mechanism of PRC2-

61 he inactivation of UPF1 led to translational repression, as manifested by a global shift in mRNAs fro

62 of heterologous sequences into rDNA leads to repression associated with reduced expression in individ

63 We further confirm that PAX7 target gene repression associates with clinical correlates of FSHD d

64 Here, we report that YtgR repression at P(trpBA) is also dependent on tryptophan b

65 c activation disappeared when hTERT promoter repression became relieved because of the loss of distal

66 P granules is not required for translational repression but is required to enrich mRNAs in the germ l

67 Transcriptional repression by B1 is the major determinant of awn suppres

68 elta mutation, demonstrating a role for SOD1 repression by Mac1p in preserving respiration.

69 3-phosphate and G6P and also mimics the G6pc repression by metformin.

70 fication of histone marks, and translational repression by miRNA (microRNA)-673/menin.

71 gulator is primed for rapid activation while repression by multiple TFs mediating Tup1-Cyc8 recruitme

72 Thus, facilitation of miRNA-mediated repression by neural APA is required for virgin females

73 thway, which primarily serves to counter GLI repression by processing GLI proteins into transcription

74 ns and demonstrate that prevention of active repression by the context of the enzyme and not H3K4 tri

75 new transcriptional circuit (a-specific gene repression by the homeodomain protein Matalpha2) evolved

76 the decapping enzyme, Dcp2, participates in repression by the N-terminus of Pumilio.

77 regulation is crucial for global translation repression by various stresses, including the unfolded p

78 While the mechanism of transcription repression by Zur is well-studied, little is known on ho

79 also demonstrate that CRISPR-mediated Myd88 repression can act as a prophylactic measure against sep

80 primarily a result from global translational repression caused by R-DPRs.

81 stone H3 lysine 27 (H3K27me3) regulates gene repression, cell-fate determination and differentiation.

82 the functional categories of transcriptional repression, chromatin modification, or DNA repair, delin

83 cer activity in which an HDAC-associated GLI repression complex regulates target genes by altering th

84 Incorporating both activation and repression components into the mechanism of tissue regen

85 coli by incorporating CRISPR activation and repression (CRISPRar) simultaneously in a single cell.

86 produced varying degrees of transcriptional repression critical for uncovering novel antibiotic resi

87 tumor-normal pairs, we discover broad genic repression domains (BGRD) on chromatin as an epigenetic

88 f target mRNAs, mediated by three N-terminal Repression Domains (RDs), which are unique to Pumilio or

89 two orientations, our prior studies detected repression due to multiple DNA loops.

90 is associated with heterochromatin and gene repression during cell-fate change(5), whereas histone H

91 ylene response factor-associated amphiphilic repression (EAR) motif in the coding region of the apple

92 lement binding factor-associated amphiphilic repression (EAR) motifs.

93 erochromatin which maintains transcriptional repression established during early development in many

94 5, although lacks a transcription activation/repression function, participates in E2-driven cellular

95 chromatin architecture, and transcriptional repression, how H3K9me3 regulates genome higher-order or

96 of metabolism and cardiac function, and its repression improves the outcome of the chronically stres

97 directly link endosomal dysfunction to RV de-repression in an FTD-ALS model without TDP-43 pathology.

98 s of dynamics and control of transcriptional repression in development.

99 However, the EIN3-mediated transcriptional repression in ethylene response is unknown.

100 We now quantitatively characterize gene repression in living E. coli by a collection of individu

101 worked more effectively than shRNAs for Pten repression in rat neural crest-derived PC-12 cells, and

102 tically, miR-142 directly targets Tgfbr1 for repression in regulatory T cells (T(REG) ).

103 nd in vivo experiments, the CRY-PER-mediated repression in vivo seemed in conflict with the in vitro

104 AGO and RNA are poorly correlated with gene repression in wild-type versus knockout cells.

105 of genes with apparent post-transcriptional repression in young adult mouse HSCs.

106 Several factors mediate this repression, in particular, factors associated with inact

107 Here we demonstrate that PAX7 target gene repression increases in these paired FSHD samples from y

108 Lipolysis is increased due to mTORC2 repression, increasing fatty acids to support cell survi

109 ng allergic disease, the mechanisms for gene repression induced by type-2 cytokines remain unclear.

110 Understanding how HSF1 regulates gene repression is a crucial question, given the dysregulatio

111 We demonstrated that PAX7 target gene repression is a superior biomarker of FSHD status compar

112 Thus, PAX7 target gene repression is a uniquely sensitive biomarker of FSHD pro

113 rget genes for miR-9/9(*)-124 and show their repression is critical for erasing fibroblast fate.

114 our results suggest that RUNX3-mediated CCL5 repression is critical for modulating anti-tumor immunit

115 Removing this repression is important as deleting CNC1 allows enhanced

116 This repression is mitigated either by stabilizing osmolytes,

117 Hence, Pax5 repression is not essential for robust plasma cell devel

118 acterization of multiple variants where this repression is released indicates that binding of inhibit

119 inal colonization, which suggests that T3SS1 repression is required for maximal virulence.

120 Alleviation of this repression is selected for during invasive infections, l

121 arget mRNA and the efficiency of translation repression is the base pairing between the 'seed' region

122 of SPINK1, and AR-antagonists alleviate this repression leading to SPINK1 upregulation.

123 Myd88 repression leads to a decrease in immunoglobulin G (IgG)

124 est a working model whereby loss of CAMTA123 repression leads to the induction of plant defense genes

125 H3K4me3 (an activation mark) and H3K27me3 (a repression mark).

126 findings demonstrate how posttranscriptional repression may alter the activity of signaling systems t

127 the H3K27me3 recognition and transcriptional repression mechanisms are only partially understood.

128 t controlling transcriptional activation and repression mechanisms by direct interaction of activator

129 However, post-transcriptional repression mechanisms targeting the 5' and 3' untranslat

130 However, recent findings challenge the RUNX1-repression model for CBFbeta-SMMHC-mediated leukemogenes

131 led by the CI repressor and the modulator of repression (MOR) antirepressor and their interactions wi

132 a TOPLESS co-repressor 4 (TPL4)-binding EAR repression motif.

133 on-CG and CG methylation, with the strongest repression occurring for enhancers located within MeCP2-

134 We present data indicating that this repression occurs, at least in part, via activation of m

135 that NS1 controls mediolateral outgrowth by repression of a growth inhibitor and promotion of cell d

136 ther found to be essential for MAF1-mediated repression of a large set of tRNA genes during serum sta

137 stically, CLSY1 mediates the transcriptional repression of a negative regulator of root branching, IA

138 This allows controlled overexpression and repression of all genes owing to saturation of inserts a

139 eta genes than alpha genes at 3 hpi and that repression of alpha gene expression late in infection is

140 the activation of lineage-specific genes and repression of alternative lineage genes, respectively.

141 We found that repression of AMPKalpha1 alleviated cognitive deficits a

142 Transcriptional repression of any one of these lncRNAs reduces the proli

143 chromatin state contribute to expression or repression of associated genes.

144 promoter which demonstrated transcriptional repression of ATX expression.

145 ncing data from SLE keratinocytes identified repression of barrier gene expression, such as filaggrin

146 ey survival signal in CRC through convergent repression of Bim expression by distinct SMS- and MYC-me

147 We thus identified sustained repression of BMP signaling as a unique constituent of t

148 sing allows miR-451 to circumvent the global repression of canonical miRNAs elicited, in part, by the

149 esting antenna sizes by light-activated Nab1 repression of CAO expression as a function of growth lig

150 e basis of silencer-mediated transcriptional repression of caspase 9.

151 iated chromatin modification participates in repression of CD86 on chronically stimulated self-reacti

152 3 and the disinhibition of LINC00313-induced repression of cell motility.

153 Repression of cellular reprogramming in germ cells is cr

154 The inflammation-induced repression of chromatin on extracellular matrix gene pro

155 tion of relevant gene modules and concurrent repression of competing fate programs precede cell fate

156 ossover control - crossover interference and repression of crossovers near centromeres, both observed

157 dependent phenotypes were accompanied by the repression of crucial autocrine factors, in particular,

158 escence in the liver, at least, in part, via repression of cyclin D1.

159 entity, in part by indirectly supporting the repression of developmentally regulated genes.

160 N14 degradation by high-risk HPV E7 leads to repression of differentiation and contributes to its car

161 ent deposition of H3K27me3 marks, leading to repression of DOG1 expression.

162 lg22-induced CAMTA3 depletion facilitates de-repression of downstream defense target genes, which inv

163 Remarkably, the HOXA-mediated repression of Ealpha is paralleled by the ectopic expres

164 Collectively, we report that CRISPR-mediated repression of endogenous Myd88 can effectively modulate

165 SC proliferation, gene expression and in the repression of endogenous retroelements (REs).

166 Although repression of formoterol-induced proinflammatory mRNAs s

167 -27 tri-methylation (H3K27me3) are linked to repression of gene expression, but the functions of repr

168 se changes that included both activation and repression of gene expression, were accompanied by the r

169 Repression of genes by Polycomb requires that PRC2 modif

170 uper-enhancers, and leads to transcriptional repression of genes critical for myeloid differentiation

171 sed loss of CTCF binding and transcriptional repression of genes with changed CTCF binding in AML, as

172 formation of fHC participates in the timely repression of genes, by resisting strong trans activator

173 the SetDB1/Wde chromatin modifier to confer repression of genomic parasites.

174 ent with regulation by OCM intermediates and repression of glycine N-methyltransferase (Gnmt).

175 Repression of Hh-signaling through Smo co-mutation in Tb

176 ed levels of H3K27me3 and defective Polycomb repression of HOX genes.

177 action of cooperating mutations to alleviate repression of Hoxa genes in order to advance to leukemia

178 molecular mechanisms that could underlie the repression of inappropriate synapse formation, and sugge

179 e immune cells contributes to the night-time repression of inflammation.

180 This clock drives rhythmic repression of inflammatory arthritis during the night in

181 SUMO ligase Ubc9 are required for efficient repression of interrupted rDNA units and variable expres

182 hat the SUMO pathway is responsible for both repression of interrupted units and control of intact rD

183 by sponging miR-519e-5p, resulting in the de-repression of its target gene Notch2 which is well known

184 This correlates with de-repression of let-7 miRNAs and is mimicked by silencing

185 b (HUSH) complex is necessary for epigenetic repression of LINE-1 elements.

186 r (SHP/NR0B2) have a role in transcriptional repression of lipogenesis.

187 , promotes CSMN subtype identity in part via repression of LMO4, a key transcriptional regulator of C

188 Repression of lysosomal activation in HSCs led to furthe

189 However, repression of macroautophagy during mitosis remains cont

190 ella identified a mechanism of translational repression of manY mRNA by the sRNA SgrS through a bindi

191 s) are short noncoding RNAs which each cause repression of many target genes.

192 tes heterochromatin-mediated transcriptional repression of MERVL elements by supporting an adequate s

193 Dose-dependent repression of methionine adenosyltransferase 1A (Mat1a),

194 In differentiated GBM cells, ERK-mediated repression of miR-199a-3p induced EGR1 protein expressio

195 Here, we show that transcriptional repression of mitochondrial deacetylase sirtuin 3 (SIRT3

196 led to short-term potentiation and long-term repression of monocyte-derived cytokine responses, and s

197 RH1-mediated lateral inhibition involves the repression of MpRSL1 activity.

198 Repression of MR and SGK1 by aldosterone-induced miRs ma

199 Therefore, Ezh2 coordinates the repression of multiple gene programs in B lymphocytes an

200 X-induced cardiac atrophy, likely because of repression of muscle RING finger 1 (MuRF1), a proatrophi

201 We found repression of MYC proto-oncogene, and up to four-fold re

202 Here, we have coupled multiplexed repression of neurodevelopmental disease-associated gene

203 omoting hair cell development, consisting of repression of neuronal-associated genes as well as activ

204 proved VCP inhibitors abrogated VCP-mediated repression of NIS function, resulting in significantly i

205 plays critical roles in the transcriptional repression of Npr1 (encoding NPRA) and receptor function

206 or, wortmannin reversed the ANG II-dependent repression of Npr1 transcription and receptor function.

207 ation in the Neoavian ancestor disrupted the repression of NRF2 by KEAP1, leading to constitutive NRF

208 on of histone 3 lysine 27, was essential for repression of numerous genes, including genes encoding i

209 sed levels of cyclin D1, A, B1, and E2F, and repression of p21 in an HIF1alpha-dependent manner, lead

210 It has been postulated that repression of Pax5 by Blimp1 is essential for plasma cel

211 lves a localized abrogation of Bmp4-mediated repression of Pax9 Analyses of GWAS data revealed a geno

212 Overexpression of PKI and its subsequent repression of PKA dysregulates these signaling pathways,

213 g RNA polymerase I (Pol I) transcription and repression of Pol II.

214 nd plays a role in sRNA-mediated translation repression of polyribosomal transcripts.

215 o P11 but were not detected at P30, due to a repression of Postn gene expression.

216 cy of a subsequent AAV9/CRISPR treatment for repression of proprotein convertase subtilisin/kexin typ

217 Not3 subunits alleviates Pumilio RD-mediated repression of protein expression and mRNA decay, whereas

218 of QC and CEI division and suggests that SHR repression of QC division depends on formation of the SH

219 egulator of macrophage phagocytosis allowing repression of rat macrophages by human CD47-positive cel

220 RePRP is sufficient and necessary for repression of root development by water deficit or ABA.

221 Strong H1 depletion causes a profound de-repression of several classes of repetitive sequences, i

222 Repression of SIDD-SATB1 interactions mediated by N(6)-m

223 inhibitor, RGFP966, inhibits BACH2-mediated repression of signal-driven luciferase expression.

224 is study implicates the selective epigenetic repression of SMAD3 in SCC-TAFs in the clinical failure

225 In contrast, Patched1 repression of Smoothened requires the opposing K(+) grad

226 and, in turn, trigger H3K27me3/EZH2-mediated repression of Snail epithelial target genes.

227 ting that ZNF274 is directly involved in the repression of SNORD116.

228 n a stress-inducible manner and functions in repression of specific HSF1 target genes.

229 e generation of photoreceptors, but also for repression of specific retinal fates and alternative gen

230 breast cancer stem cells through epigenetic repression of stemness master transcription factors NANO

231 sponses, and short-term as well as long-term repression of T-cell reactivity to unrelated pathogens.

232 /P-SMAD1/5/8 ratio, a change associated with repression of terminal chondrocyte differentiation.

233 lysosome biogenesis through mTORC1-dependent repression of TFEB nuclear translocation.

234 d PRL stimulation leads to SMAD7 activation, repression of TGF-beta1, resulting in CD56(+) cell devel

235 y incorporates a cryptic intron required for repression of that gene.

236 ces coccoid formation and is associated with repression of the antitoxin promoter and enhanced proces

237 scular dystrophy (FSHD) is caused by loss of repression of the DUX4 gene; however, the DUX4 protein i

238 the induction of the florigen gene FTa1 and repression of the floral repressor LF Our results establ

239 f metformin on liver gluconeogenesis involve repression of the G6pc gene, which is regulated by the c

240 e RND-negative background resulted from OmpR repression of the key ToxR regulon virulence activator a

241 ching by simultaneous activation of TFL1 and repression of the LAP1 pathway.

242 functioned as a virulence regulator through repression of the LysR-family transcriptional regulator

243 o homeobox protein 1 (PROX1), which relieved repression of the matrix metalloproteinase MMP14.

244 sion, amp1 did not prevent the translational repression of the miR156 target SPL9 or the miR159 targe

245 tein kinase C beta1 (PKCbeta1) signaling and repression of the muscle ring-finger protein-1 (MURF1)-m

246 hat function in part through transcriptional repression of the MYC-driven oncogenic program via mecha

247 and Rhn1, mutations of which result in hyper-repression of the PHO regulon.

248 conclusion, pronounced antioxidant activity, repression of the PPARgamma pathway, and higher expressi

249 tamoxifen, suggesting that they converge on repression of the same targets.

250 izing this transient state leads to enhanced repression of the target mRNA in cells, revealing the im

251 mRNA) can act cooperatively, leading to more repression of the target mRNA than expected by independe

252 a/gamma signaling, MyoD phosphorylation, and repression of the terminal myogenic commitment factor My

253 outcompeting neighboring stem cells through repression of their proliferation.

254 r indirectly contribute to the transcription repression of these genes.

255 hich stimulates JG cell renin production via repression of transcription factors E2f1 and Pde3b.

256 ilencing establishment proceeded via gradual repression of transcription in individual cells over sev

257 er, global loss of HDAC3 also results in the repression of transcription, the mechanism of which is c

258 include the deacetylation of histone H3 and repression of transcription.

259 er chromatin accessibility for activation or repression of transcription.

260 nabinoid receptors, thus inducing epigenetic repression of transcriptional regulatory networks contro

261 ilapia eggs which is known to play a role in repression of transposon elements and is therefore thoug

262 ty by dysregulating spliceosome function via repression of TRIB3, the loss of which may, in the long

263 nes during serum starvation, indicating that repression of tRNA genes by Pol II is dynamically regula

264 A, was sufficient to completely overcome the repression of type 3 secretion system activity normally

265 Pax5 mediates the transcriptional repression of Wapl through a single Pax5-binding site by

266 tivated receptor gamma (PPARgamma)-dependent repression of Wnt expression, whereas increased producti

267 Our results indicate that direct repression of WOX9 by WUS clade repressor STF/LAM1 is re

268 cing, 3' end processing, miRNA-mediated mRNA repression, of AR and AR-V expression and the potential

269 cts of brain- and isoform-specific AMPKalpha repression on AD pathophysiology.

270 s, as part of the intrinsic defenses, impose repression on incoming DNA.

271 TE ZIM-DOMAIN (JAZ) proteins, which relieves repression on MYC transcription factors that execute def

272 Just as critical is the process of gene repression or silencing.

273 PR-1 was a component of a primitive Polycomb repression pathway.

274 This epigenetic de-repression permits expression of the transcription facto

275 of these tools by examining ADP1's catabolic repression regulation, creating a strain with improved p

276 activities are required for transcriptional repression remains controversial.

277 chromatin modification but the mechanism of repression remains unclear.

278 lly, we discover that Polycomb-mediated gene repression requires PRC1 catalytic activity.

279 Interestingly, the NarS-mediated repression selectively targets the nirC cistron of the l

280 nts with different expression activation and repression strengths.

281 oping and comparison of the engineered TALED repression system with the natural lac repressor system.

282 ins form memory of transient transcriptional repression that is necessary for development.

283 eracts with EIN3 to regulate transcriptional repression that leads to an inhibition of shoot growth i

284 epigenetic scenario associated with CcMADS19 repression, thereby allowing the activation of CiFT2 the

285 ruitment of PRC2 and that HIV Tat alleviates repression through disruption of this association.

286 -binding protein that mediates translational repression through mTOR-dependent signaling and that ALS

287 topic PHF7 overcomes its own transcriptional repression through promoter switching.

288 ing that LINC00313 may mediate transcription repression through recruitment of PRC2 and that HIV Tat

289 ng H3K27me3 recognition with transcriptional repression through the alteration of Pol II phosphorylat

290 Cohesin ensures efficient Esg-dependent gene repression to maintain stemness and intestinal homeostas

291 ses linked glucose starvation-mediated H2Aub repression to the activation of genes involved in the en

292 ssociated with transcriptional activation or repression under steady-state growth conditions.

293 Live-cell imaging after individual ASD-gene repression validated this functional module, confirming

294 3A to lipogenic genes, leading to epigenetic repression via DNA methylation.

295 ssion by protecting developmental genes from repression via repelling PRC2 and DNA methylation machin

296 While the mechanism of CRY-mediated repression was explained by both in vitro and in vivo ex

297 This glucose-dependent transcriptional repression was in part mediated by O-GlcNAcylation of th

298 investigating the mechanisms underlying GLI repression, we find that a subset of GLI binding regions

299 and Ptch1/Boc mediate the process of Smo de-repression with different kinetics, through distinct mod

300 ults in robust CNS axon regrowth, while PTEN repression with short hairpin RNA (shRNA) improves regen