ライフサイエンスコーパス: repression domain

1 nd repress transcription via small, portable repression 'domains'.

2 The NID also acts as a transcriptional repression domain.

3 C-terminal-binding protein also bind the MLL repression domain.

4 neered as fusions with a KOX-1 transcription repression domain.

5 explored the mechanism of action of the MLL repression domain.

6 by using a synthetic, hormone-regulated KRAB repression domain.

7 inding and also functions as a transcription repression domain.

8 s and contains an N-terminal transcriptional repression domain.

9 this localization depends on the N-terminal repression domain.

10 GATA family with a separable transcriptional repression domain.

11 s of BRCA1 may function as a transcriptional repression domain.

12 3 C-terminus that can function as a portable repression domain.

13 BD) of the estrogen receptor and to the KRAB repression domain.

14 -terminal activation domain and a C-terminal repression domain.

15 served PLDLS motif within the amino-terminal repression domain.

16 sor of target gene expression and includes a repression domain.

17 l-CpG-binding domain or in the transcription repression domain.

18 PTIP to Pax2 is inhibited by the octapeptide repression domain.

19 teracts with HDACs via its carboxyl-terminal repression domain.

20 t the Giant effector domain is an autonomous repression domain.

21 ree transcription activation domains and one repression domain.

22 ressing the Ci zinc finger domain fused to a repression domain.

23 -terminal region also encoded a transferable repression domain.

24 Y1 have been identified as a transcriptional repression domain.

25 n coincides with the previously defined Tup1 repression domain.

26 sion, possibly by contributing an additional repression domain.

27 em zinc finger motifs and an N-terminal SNAG repression domain.

28 nd LSD1 associate with Gfi-1/1b via the SNAG repression domain.

29 ethyl DNA binding domain and transcriptional repression domain.

30 pped to Ser3486 and Thr3568 within the SHARP repression domain.

31 interaction with Brm and mSin3A through its repression domain.

32 erminal of ZIC2 contains both activation and repression domains.

33 s contains both transcription activation and repression domains.

34 reveal that MyoR contains two nonequivalent repression domains.

35 n be subdivided into distinct activation and repression domains.

36 ted receptor interaction and transcriptional repression domains.

37 AP-1 silencing and the de novo design of new repression domains.

38 Other PUF proteins lack these repression domains.

39 es, including two activation domains and two repression domains.

40 TN-2 were shown to function as transcription repression domains.

41 ressors which should therefore have specific repression domains.

42 , using regions of the ncRNAs referred to as repression domains.

43 ein, acts as a repressor containing multiple repression domains.

44 opment and a central domain of RUNX1, termed repression domain 2 (RD2), was defined as being required

45 cho (Gro), in addition to possessing a third repression domain, 3R.

46 SAP180 has two repression domains: a C-terminal domain, which interacts

47 IC itself is targeted to the transcriptional repression domain (aa179 to 361) of CBF1.

48 Because the MLL repression domain activity was only partially relieved w

49 xpression of exogenous BMI-1 potentiates MLL repression domain activity.

50 f these proteins as fusions to activation or repression domains allows transcription to be specifical

51 eting with activators, but requires specific repression domains along with its DNA-binding domain.

52 proteins and implicated as a transcriptional repression domain, although few target genes for KRAB-co

53 However, deletion of the repression domain (amino acids 566-624) of TBX3 complete

54 al activation domain (amino acids 1-110) and repression domains (amino acids 111-188 and the homeodom

55 iating sequence-specific DNA binding and two repression domains: an N-terminal BTB/POZ domain and a c

56 factor bearing an ERF-associated amphiphilic repression domain and binding to the ACGTCAGTG sequence

57 n addition, SAFB1 contains a transcriptional repression domain and can bind certain hormone receptors

58 ABF-1 contains a transcriptional repression domain and is capable of inhibiting the trans

59 nt of histone deacetylases (HDAC) to the MLL repression domain and mediates HOX gene repression.

60 t1 belongs, has a transcriptional activation/repression domain and RNA recognition motifs and has a s

61 ies suggest that phosphorylation of both the repression domain and the chromatin binding domain acts

62 uncated protein consisting of the N-terminal repression domain and the DNA-binding homeodomain repres

63 eins with a VP64 activation domain or a KRAB repression domain and the transcriptional control impose

64 mains of Crt1 and identified two independent repression domains and a region required for gene activa

65 culture assays revealed the presence of two repression domains and a single activation domain within

66 RNA, bind Pol II with high affinity but lack repression domains and hence do not inhibit transcriptio

67 This function is mediated through two repression domains and is dependent upon the promoter co

68 onservation of the N-terminal activation and repression domains (and not the RS/RNA recognition motif

69 2 ZNF that contains 9 finger domains, a KRAB repression domain, and a SCAN domain and identified more

70 binding proteins, where it may function as a repression domain, and less frequently in actin-binding

71 This complex binds via the CBF1 repression domain, and mutants defective in repression f

72 aining the AML1 DNA-binding domain, the KRAB repression domain, and the Estrogen receptor ligand bind

73 ossesses potent transcription activation and repression domains, and is necessary for c-myc expressio

74 egions of structural divergence; while their repression domains are structurally and functionally con

75 including most of the previously identified repression domain, are necessary and sufficient for coac

76 pression despite having the same C- terminal repression domain as IRF-2, suggesting that the relative

77 stitute region-specific but gene-nonspecific repression domains, as a number of heterologous genes tr

78 SAP130 has a repression domain at its C terminus that interacts with

79 criptional repressor that contains a modular repression domain at its carboxyl terminus.

80 to a putative Kruppel associated box (KRAB) repression domain at the N-terminus.

81 tumor-normal pairs, we discover broad genic repression domains (BGRD) on chromatin as an epigenetic

82 ethyl DNA binding domain and transcriptional repression domain both could function as nonspecific DNA

83 EMPRANILLO1 (TEM1) and is mediated by the B3 Repression Domain (BRD) located on both RAV1 and TEM1.

84 ylene response factor-associated amphiphilic repression domain but differ in the presence of an addit

85 tain both Groucho-dependent and -independent repression domains, but the extent to which this distinc

86 Brk possesses at least three repression domains, but these are not equivalent; one, 3

87 P1 cooperatively function as a transcription repression domain by recruiting the histone deacetylase

88 ption activation domain, and a transcription repression domain called the octapeptide.

89 n a context-dependent manner, the N-terminal repression domain can function in a heterologous context

90 nsistent with these findings, Ikaros and its repression domains can interact in vivo and in vitro wit

91 nducible deactivated Cas9 is fused to a KRAB repression domain, can specifically and reversibly inhib

92 inus of FIR contained an activator-selective repression domain capable of acting in cis or even in tr

93 NA encoding SOX3DeltaC-EnR, a SOX3-engrailed repression domain chimera.

94 assay, the relative activities of different repression domains closely parallel those seen in vivo,

95 The transcription repression domain comprises the C-terminal 154 amino aci

96 These results reveal a novel transcription repression domain, confirm the presence of a previously

97 D can function as an autonomous and portable repression domain, demonstrating that it is sufficient t

98 In these assays, the Hairy repression domain did not exhibit previously described l

99 pressor assay, indicating the existence of a repression domain distinct from SSX-KRAB.

100 A carboxy-terminal repression domain distinct from the well-characterized T

101 e show that mutation of the putative Groucho-repression domain does not ameliorate Znf703 effects on

102 with one of these being an active, portable repression domain (domain I) and a second being an auxin

103 nal/functional analysis of the transcription-repression domain encoded in the N-terminal 80 amino aci

104 A conserved transcriptional repression domain exists in both PLAG1 and PLAGL2, whose

105 egulatory domains such as AT hooks (exon 3), repression domain (exon 6), zinc finger motifs (exon 8)

106 46 mice, in which Runx1 lacks the C-terminal repression domain, expression of MrgA/B/C genes is drama

107 the repressor domain 3 of N-CoR, while other repression domains failed.

108 n p66beta and the zinc finger/leucine zipper repression domain found in Foxp1/2/4.

109 scription, and this activity requires both a repression domain found in the N-terminal 137 amino acid

110 ll nuclear extract demonstrated that the Eve repression domain functions by preventing the assembly o

111 This C-terminal repression domain functions in a BRCA1-, histone deacety

112 A 65-amino-acid polypeptide containing the repression domain fused to the Ga14 DNA binding domain r

113 iofacial development, that a transcriptional repression domain fusion, MadFlagWdr68, failed to suppor

114 y responsible for this regulation to the H2A repression domain, HAR.

115 the ET protein reveals a novel transcription-repression domain highly conserved among ET, human TBX3,

116 ighly conserved domains of ETO interact with repression domains I and III of N-CoR.

117 In addition to a region containing an active repression domain identified in cell culture assays, we

118 otif that engages a conserved PPLXP motif in repression domain III of N-CoR.

119 omain (RHD) and a C-terminal transcriptional repression domain in AML1/ETO are required for transform

120 The repression domain in both Nrf1 and C/EBPbeta was determi

121 We have identified a transcriptional repression domain in Dnmt1 that functions, at least part

122 ipped C terminus acts as a Groucho-dependent repression domain in early Drosophila embryos.

123 identified a novel evolutionarily conserved repression domain in Elk-1, termed the R motif, which se

124 Analysis of the N-terminal repression domain in Foxp1, Foxp2, and Foxp4 shows that

125 the DNA-binding domain of GAL4, we mapped a repression domain in hEZF to amino acids 181-388.

126 We previously identified a transcriptional repression domain in MLL, which contains a region with h

127 Mutations in a putative repression domain in Mox4 caused constitutive expression

128 The R motif is related to the CRD1 repression domain in p300 and can functionally replace t

129 We also identified a minimal repression domain in PRDI-BF1 that is sufficient for tra

130 ous reporter assay, we identify a tripartite repression domain in SnoN.

131 tified a trichostatin A-sensitive autonomous repression domain in the amino terminus of Runx2.

132 We show that CBFbeta/SMMHC contains a repression domain in the C-terminal 163 amino acids of t

133 Here, we identify a transcriptional repression domain in the carboxy-terminal region of the

134 (amino acids 589-631) that has homology to a repression domain in the corepressor protein NCoR2/SMRTe

135 cation of a novel cis-acting transcriptional repression domain in the E protein family of bHLH transc

136 r protein genes, making it the most abundant repression domain in the human proteome.

137 urther shows the presence of a Wnt signaling repression domain in the SOX17 HMG box.

138 fy a novel, highly conserved transcriptional repression domain in these proteins.

139 lly distinguishable from the N-terminal KRAB repression domain in ZBRK1, which exhibits no BRCA1 depe

140 These findings show that EAR repression domains in a subgroup of JAZ proteins repress

141 Other repression domains in Gro may function in a histone deac

142 The presence of multiple repression domains in Nkx6 supports Nkx6's role as a rep

143 have characterized four distinct autonomous repression domains in RIP140, termed RD1-4, that are hig

144 nal co-repressors are known to contact other repression domains in RUNX1, the factors that bind to RD

145 confirmed previous findings of two separate repression domains in the N and C termini.

146 that there are two separate transcriptional repression domains in VIPR-RP, located between amino aci

147 Deletion of this repression domain increased gene transcription from a ne

148 While the MyoR C-terminal repression domain inhibits transcription in a context-de

149 nteracted in vivo with Hir2p, and both Hir1p repression domains interacted with full-length Hir1p.

150 Remarkably, this repression domain interacts specifically with hGrg, TLE1

151 sion protein containing the Drosophila Hairy repression domain interferes with notochord differentiat

152 e we test the hypothesis that the cis-acting repression domain is a conserved feature of PAX3 and PAX

153 The SNAG repression domain is comprised of a highly conserved 21-

154 that the interaction between TBP and the E1A repression domain is direct and specific.

155 ression domain, supporting the idea that the repression domain is implicated in interactions between

156 e IL-10 expression, but a C-terminal minimal repression domain is necessary.

157 The KRAB repression domain is one of the most widely distributed

158 transgenes that the widely conserved in vivo repression domain is required for the normal function of

159 primary embryo fibroblasts and that the RD1 repression domain is required for this activity.

160 In chromosomal translocations, the MLL repression domain is retained in the leukemogenic fusion

161 Although the N-terminal repression domain is sufficient for partial repression,

162 This minimal repression domain is sufficient for the association of C

163 he protein separate from the DNA binding and repression domains is necessary and sufficient for gluco

164 A large region of Ubx, including the repression domain, is required for interaction with DIP1

165 The N terminus of Crt1 is the major repression domain, it directly binds to the Ssn6-Tup1 co

166 othelial cell lines or, when combined with a repression domain, knocked down expression.

167 n independent and homologous transcriptional repression domain lies within the N-terminal end of the

168 DNA-binding zinc fingers and on a separable repression domain located in the N terminus.

169 cumulative data suggest that the C-terminal repression domain, located near the first WD repeat, pla

170 ntly represses basal transcription, with the repression domain mapped to the N-terminal silencing med

171 ufficient to repress transcription, and this repression domain mediates a two-hybrid and physical int

172 ptapeptide repeat, suggesting that the PIE-1 repression domain might target a protein complex that ca

173 AL4-COUP-TF2(117-414), but not by a COUP-TF2 repression domain mutant.

174 and the Drosophila engrailed transcriptional repression domain (NFIen) was conditionally expressed in

175 Expression vectors containing the repression domain of C/EBPepsilon strongly inhibited gen

176 r Notch1, Notch2 interacted with the minimal repression domain of CBF1 and was targeted to CBF1 throu

177 r studies show that TFIID interacts with the repression domain of Crt1, suggesting that the derepress

178 by fusing the SpOtx homeodomain to an active repression domain of Drosophila Engrailed.

179 e Siamois homeodomain was fused to an active repression domain of Drosophila engrailed.

180 motif which can be negatively regulated by a repression domain of FBP.

181 The repression domain of FIR targeted only TFIIH's p89/XPB h

182 We also show that the repression domain of hTR alpha maps to the C-terminal li

183 re L is leucine and x is another amino acid) repression domain of IAA3, IAA6, or IAA19 confers enhanc

184 at interact specifically with the C-terminal repression domain of Interferon Regulatory Factor-2 (IRF

185 The transcriptional repression domain of JMJ is critical for the interaction

186 of the C-terminal binding protein-dependent repression domain of Knirps.

187 sferase homology domain, and transcriptional repression domain of MLL fused to the CREB binding domai

188 directly demonstrate that the amino-terminal repression domain of Mxi1-SR functions solely to recruit

189 repression involved the CRD1 transcriptional repression domain of p300.

190 11, a domain that is homologous to the major repression domain of Qin.

191 e effects of amino acid substitutions in the repression domain of selected Aux/IAA proteins.

192 nd USF that is dependent upon the C-terminal repression domain of Stra13 and the DNA-binding domain o

193 s bind to the pointed domain and the central repression domain of TEL, respectively.

194 ividuals with HPE affect the transcriptional repression domain of TGIF, the DNA-binding domain or the

195 ctivation domain of Xcad3 is replaced by the repression domain of the Drosophila Engrailed protein.

196 An interaction screen with the repression domain of the orphan receptor RevErb identifi

197 The zinc finger and repression domains of KLF3 plus the MADS box and transcr

198 We assayed CtBP-dependent and -independent repression domains of Knirps in Drosophila embryos, and

199 Two characterized repression domains of MeCP2 are involved in tethering th

200 n the methyl-CpG-binding and transcriptional-repression domains of MeCP2.

201 ons of the DNA binding or C-terminal minimal repression domains of p53 abolished its ability to repre

202 tion analysis was used to define the minimal repression domains of TEL.

203 p-Leu-Ser-X-Lys (P-DLS-K), is present in the repression domains of two unrelated short-range represso

204 a presented indicate that the activation and repression domains of Vnd are complex, and whether Vnd f

205 s indicate that RYBP binds within the known "repression domain" of E2F6.

206 domain acted as an independent transcription repression domain on a heterologous activation domain.

207 ind that the BRCA1-dependent transcriptional repression domain on ZBRK1 includes elements that modula

208 n analysis of HIR1 has revealed two separate repression domains: one in its N terminus, where seven c

209 ET, which has been demonstrated to contain a repression domain, only minimally diminishes the ability

210 The dominance of Aux/IAA repression domains over activation domains in ARF transc

211 we have named this region the p53 N-terminal Repression Domain (p53-NRD).

212 Histone deacetylase 1 interacts with the MLL repression domain, partially mediating its activity; bin

213 A conserved SNAG repression domain present in all vertebrate Snail protei

214 ression motif (alpha-HRM) located within the repression domain (R1) of TIEG2.

215 is a potent transcriptional repressor whose repression domain (RD) interacts directly with SMRT and

216 A number of short repression domain (RD) sequences have previously been id

217 In a yeast 2-hybrid screen with GRIP1 repression domain (RD)-containing fragment, we repeatedl

218 via an intrinsic and transferable C-terminal repression domain (RD).

219 We show that a key repression domain (RD1) resides in the Tbx3 C-terminus t

220 PIASy contains two transcriptional repression domains, RD1 and RD2.

221 The second repression domain (RD2) of PLZF, not the POZ/BTB domain,

222 t bind TPL/TPR typically contain one or more Repression Domains (RDs) that mediate the interaction.

223 Each corepressor contains multiple repression domains (RDs), the significance of which is u

224 f target mRNAs, mediated by three N-terminal Repression Domains (RDs), which are unique to Pumilio or

225 Further analyses mapped a novel repression domain (RepD1) to a small region at the N-ter

226 s localized to amino acids 1-35, whereas the repression domain resides in amino acids 67-168.

227 cing complex through MeCP2's transcriptional repression domain results in histone deacetylation and c

228 no acid substitutions in the transcriptional repression domain revealed that activation of gene expre

229 , we annotate 374 activation domains and 715 repression domains, roughly 80% of which are new and hav

230 udy is to further define and distinguish the repression domain(s) in human GW182/TNGW1.

231 esults point to intrinsic differences in the repression domain(s) of IAA proteins and suggest that so

232 levels, a Tbx3 mutant lacking its C-terminal repression domain shows no anti-apoptotic activity and f

233 rovide a DNA-binding module fused to the EAR-repression domain (SRDX) to generate a chimeric represso

234 RPW motif to be a functional transcriptional repression domain sufficient to confer active repression

235 ion of the inv(16) fusion protein contains a repression domain, suggesting a molecular mechanism for

236 but distinct from the Ssn6-Tup1 binding and repression domain, suggesting that Crt1 may have activat

237 ity of HESX1(R160C) is mediated by the Hesx1 repression domain, supporting the idea that the repressi

238 SpEts4 DNA binding and Drosophila engrailed repression domains, suppresses its transcription.

239 e IAA proteins have stronger or more complex repression domains than others.

240 A-binding domain, we have identified a PIE-1 repression domain that appears to inhibit the transcript

241 chromoshadow domain (CSD) of HP1 is a potent repression domain that binds directly to all four previo

242 rminal domain of Vnd contains a putative eh1 repression domain that binds Groucho in vitro.

243 pa, one of which is identical to the central repression domain that binds the Notch effector fragment

244 4-Giant fusion proteins identified a minimal repression domain that contains a sequence motif, VLDLS,

245 t the hypothesis that Eve contains an active repression domain that functions specifically to prevent

246 ltransferase-mediated pathways, as well as a repression domain that interacts with the histone deacet

247 oprotein encodes an N-terminal transcription repression domain that is essential for early viral func

248 at domain I in Aux/IAA proteins is an active repression domain that is transferable and dominant over

249 identical to a previously identified HoxA10 repression domain that mediates interaction with transcr

250 is an HMG-domain, DNA binding protein with a repression domain that recruits the Tup1/Ssn6 general re

251 We determine that HoxA10 has endogenous repression domains that are not functionally altered by

252 the p300 CRD1 motif represent a new class of repression domains that are regulated in a context-depen

253 A 107 amino acid stretch of the SnoN repression domain, that contains two of the subdomains,

254 lization and acts together with the adjacent repression domains (the transcription repression domain

255 3) was also fused to a human transcriptional repression domain, the mSIN3 interaction domain, and int

256 In contrast to these two repression domains, the T-box was capable of weakly acti

257 udies also identify a new function for ncRNA repression domains: they stabilize interactions of ncRNA

258 hat p300 can serve as a scaffold for the E1A repression domain to access specific cellular gene promo

259 Importantly, fusing a repression domain to B1 RNA stabilizes its interaction w

260 The ability of the E1A repression domain to block TBP interaction with the TATA

261 ZFM1 comes from the ability of its specific repression domain to function when fused to Gal4 and tet

262 roposed mechanisms include tethering the E1B repression domain to p53-responsive promoters via direct

263 ssor approach that directs a transcriptional repression domain to target genes deregulated by the PAX

264 Fusion of this repression domain to the VP16 activation domain inhibite

265 By tethering activation and repression domains to Cascade, we modulate the expressio

266 truncate all or some of the transcriptional repression domain (TRD) affect the ability to repress tr

267 The transcription repression domain (TRD) of MeCP2 will repress transcript

268 It contains a transcriptional-repression domain (TRD) that can function at a distance

269 its MBD and also contains a transcriptional repression domain (TRD).

270 binding domain (MBD) or the transcriptional repression domain (TRD).

271 ion, both of which disrupt the transcription repression domain (TRD).

272 jacent repression domains (the transcription repression domain [TRD] and the corepressor-interacting

273 This novel repression domain was active on two target genes that ar

274 This repression domain was also found to functionally and dir

275 and SRC1 corepressed, and the GRIP1-specific repression domain was dispensable.

276 on causing a V288X stop in the transcription-repression domain was identified in a woman with motor-c

277 A repression domain was identified near the N terminus of

278 The EAR repression domain was required for MYBH-regulated leaf s

279 ped protein, outside the Groucho-independent repression domain, we have identified a conserved C-term

280 The major determinants of the repression domain were shown to be amino acid residues F

281 Activation and repression domains were detected in their common amino e

282 Two repression domains were identified in H2A.

283 tem, distinct transcriptional activation and repression domains were identified.

284 ARF MRs alone function as activation or repression domains when targeted to reporter genes via a

285 ional repressor with a minimal 36 amino acid repression domain which can mediate promoter-specific re

286 10 amino acids 224-249 as a Pbx1-independent repression domain, which interacts with histone deacetyl

287 The second domain of Dr1 is the repression domain, which is glutamine-alanine rich.

288 In addition, we identified a C-terminal repression domain, which is independent of Ssn6-Tup1 and

289 ion containing the SID represents a dominant repression domain whose activity can be transferred to a

290 d the interaction of the fused activation or repression domain with endogenous proteins.

291 ssion activity, we have identified a minimal repression domain within giant that encompasses residues

292 ng domain assay, we mapped a transcriptional repression domain within the N-terminal region of HBO1.

293 n within a common region and a counteracting repression domain within the OVO-A-specific region.

294 f a portable BRCA1-dependent transcriptional repression domain within ZBRK1 composed of zinc fingers

295 at EGR activity is modulated by at least two repression domains within NAB2, one of which uniquely re

296 Two complementary cis-regulatory repression domains within pri-miR-17 approximately 92 ar

297 ealed the presence of at least two separable repression domains within TGIF.

298 Distinct activation and repression domains within the RFX1 protein were further

299 sed transcriptional assays to identify three repression domains within TIEG1 and TIEG2 that we call R

300 zinc finger proteins fused to activation or repression domains, zinc finger transcription factors (T