ライフサイエンスコーパス: requirement of

1 35), 59 days higher than the legal reporting requirement of 1 year.

2 her, these data provide new insight into the requirement of 12-LOX in pancreatic organogenesis and is

3 was the costliest approach (total financial requirements of 16-24 USD/person/year), followed by cont

4 Structure-activity studies revealed the requirement of 4,8-dimethylcoumarin-3-acetic acid for ac

5 er adjacent motif (PAM) and guide RNA (gRNA) requirements of 79 Cas9 proteins, thus identifying at le

6 Our results demonstrate the requirement of a balance between N metabolism and ROS pr

7 f studying single entities, it is limited by requirement of a catalytically active particle impacting

8 als, our results provide a mechanism for the requirement of a continuous pulling force of >15 pN to f

9 The requirement of a fully functioning BAX protein for the f

10 By dropping the requirement of a fully lossless compression and using th

11 cap-snatching mechanism and demonstrate the requirement of a host cell factor for successful cap sna

12 gical protein-induced neurotoxicity, and the requirement of a particular glial cell type in neurodege

13 Here, we report the requirement of a positively charged motif in a subset of

14 re method, and comparable to PCR but without requirement of a thermal cycler.

15 c nanostructures from monolayers without the requirement of a van der Waals gap.

16 We show that estimating the memory requirements of a job is possible using the same methods

17 esent an approach that utilizes the physical requirements of a monotonic dependence of the built-in e

18 horylase, which evolved to satisfy metabolic requirements of a particular organism.

19 be differentially recruited depending on the requirements of a sound-driven behavior.SIGNIFICANCE STA

20 ncept of relative flux, which eliminates the requirement of absolute quantitation in traditional MFA

21 By decoupling the contradictory requirements of accelerating charging and discharging pr

22 hat control transgene expression without the requirement of additional protein components(1-5).

23 This information suggests the requirement of adequate soil moisture during flowering a

24 To compare and contrast the genetic requirements of adhesion to each host ligand, we generat

25 ncerns include high postoperative morbidity, requirement of advanced surgery, and pelvic recurrence a

26 theory that recognizes the representational requirements of agency can do likewise.

27 The running time and space requirement of all procedures is linearithmic in the num

28 u in the presence of (238)U, eliminating the requirement of alpha spectrometry.

29 Together, these findings reveal a crucial requirement of amino acid signaling for licensing and su

30 g SARS-CoV-2 antibodies without the specific requirement of an antibody.

31 ence imaging applications are limited by the requirement of an externally provided luciferin substrat

32 an insufficiently high vacuum to satisfy the requirement of an increase in the mean free path of ions

33 modern column platform without the expensive requirement of an ultra-high pressure liquid chromatogra

34 The requirements of an active isoform include high adsorptio

35 to the prescribers, learn the mechanics and requirements of an ASP, and complete a preliminary quali

36 e or more analytical procedures can meet the requirements of an ATP.

37 toplankton-derived sulfonates support growth requirements of an open-ocean isolate of the SAR11 clade

38 IR) spectroscopic method compatible with the requirements of an operation room for the evaluation of

39 e clamping, and in two-terminal devices, the requirement of anisotropic in-plane strain.

40 However, due to stringent requirements of anti-commuting reflection symmetries, it

41 Our mHealth system appropriately met the requirements of application in patients' homes, with the

42 d stability by Arf6 and establish the strict requirement of Arf6 for RhoB-specific subcellular target

43 However, an assessment of B cell-intrinsic requirement of ATM in humoral responses in vivo was conf

44 demonstrate that PRDM15 fuels the metabolic requirement of B-cell lymphomas and validate it as an at

45 ied in the 571 subjects reflects the complex requirements of B-cell antigen signaling, activation, su

46 Here we examine the requirement of BCL9/9l, constituents of the Wnt-enhanceo

47 These insights into the differential requirement of BD1 and BD2 for the maintenance and induc

48 ortance of these specialized centers and the requirement of better education for primary healthcare a

49 drug structures that satisfy the structural requirements of blood-brain barrier diffusion and FAAH s

50 ole for FGF in survival/proliferation, and a requirement of BMP for NC maturation.

51 docrine factors that integrate the metabolic requirements of bone formation with global energy balanc

52 s of Smarcal1 and Zranb3 and demonstrate the requirement of both proteins to stabilize replication fo

53 his structure also provides evidence for the requirement of both substrates (sugar and nucleotide) to

54 This indicates not only different functional requirements of both sexes in the new environment but al

55 The latter probably reflects the requirement of C-type retroviruses for tighter membrane

56 rofluidic-induced sleep meets the behavioral requirements of C. elegans sleep and depends on multiple

57 y ATG16L1 via its WD40 domain, bypassing the requirement of canonical upstream autophagy machinery.

58 ed features of PIN clusters and the cellular requirements of cargo clustering remain unclear.

59 recognition, and in agreement with the known requirement of CD20 to form clusters to elicit a biologi

60 d novel functions is challenging because the requirement of cell viability limits the mutations that

61 we discover modifications that overcome the requirement of cholesterol for membrane rupture, which m

62 shed, providing important information on the requirement of CHPK for interindividual spread.IMPORTANC

63 transduction, which is unexpected given the requirement of cilia for Shh transduction.

64 We uncover a specific requirement of CL for in vivo reconstituted MCU stabilit

65 Functional and structural requirement of CL for mitochondrial membrane proteins ha

66 ubtle differences in life histories, thermal requirements of closely related parasites, climate oscil

67 very well for the "paradigm for the electron requirements of clusters", in which a closo-cluster that

68 However, the requirement of coherence and the scanning mechanism limi

69 st promising candidates to meet the low-cost requirements of commercial applications, because of thei

70 icial intelligence while reducing the energy requirements of computing platforms.

71 factors with glycemic progression defined as requirement of continuous insulin treatment, or 2 consec

72 Critically ill patients with requirement of continuous renal replacement therapy (CRR

73 low-affinity type I interactions without the requirement of cooperative receptor interactions.

74 We show the requirement of COPI-coatomer subunits impacted at least

75 on-scattering curve fits, constrained by the requirement of correct disulfide bridges in the hinge, r

76 iency of photoactivation is explained by the requirement of correct occupancy of these metal-binding

77 The large power requirement of current brain-machine interfaces is a maj

78 -of-function mutants are associated with the requirement of dbf function for translation of specific

79 rward adaptation to the different structural requirements of dedicated nuclear or hybrid imaging agen

80 nt that allows modification according to the requirements of different types of flexible energy devic

81 However, ULM is currently limited by the requirement of dilute MB concentrations to ensure spatia

82 The possible legal requirements of distribution must be balanced with (a) t

83 However, requirements of DNP probes such as biocompatibility, sig

84 The survey assessed time requirements of documentation-related activities perform

85 is of compartmentalized signaling revealed a requirement of DOPr endocytosis for activation of PKC at

86 nse to genomic damage, which may reflect the requirements of early embryogenesis.

87 This study establishes the differential requirements of EC-FAK-Y397 and EC-FAK-Y861 phosphorylat

88 robes have been tailor-made to meet specific requirements of electrochemical quantitative loop-mediat

89 One of the major requirements of eM is its responsiveness across auditory

90 ation could help define the optimal nutrient requirements of embryos in culture and provide a means o

91 Intravitreal dexamethasone reduced the requirement of enucleation or evisceration (p = 0.01).

92 Data on nutrient requirements of exclusively breastfed infants are limite

93 ng of rRNA intermediates, we investigate the requirements of exonucleases known to be involved in 5.8

94 -BEAT is a promising approach to meet future requirements of experiments and applications in the fiel

95 pproach to produce useful chemicals with the requirement of external electrical energy input.

96 atures of "true memory" T cells, without the requirement of first encountering cognate antigen.

97 ation were combined to determine the minimal requirement of FL BRCA2 transcripts.

98 rendering it compatible with the processing requirements of flexible plastic substrates.

99 However, the requirement of Fndc5 in mediating the beneficial effect

100 We utilized the requirement of Forkhead box A1 (Foxa1) for transcription

101 The essential amino acid requirements of formula-fed infants have been reassessed

102 rains to wild-type levels, corroborating the requirement of FST1 for transport of flavonol-3-o-sophor

103 Here, we analyzed the requirement of GATA cofactor ZFPM1 in the development of

104 , our results demonstrate the stoichiometric requirement of GHMT expression for structural and functi

105 such tradeoffs, based on the opposing enzyme requirements of glycolysis versus gluconeogenesis.

106 In summary, the requirement of glycolytic reprogramming for proinflammat

107 tive approach for addressing broader impacts requirements of grants, while also advancing researcher

108 alling responses in plants and establish the requirement of H2AX phosphorylation for plant survival u

109 These studies confirm the critical requirement of having at least three substituents on the

110 Our results reveal a specific requirement of Hbs1 in male gametogenesis in Drosophila

111 The metabolic requirements of hematopoietic stem cells (HSCs) change w

112 Here, we identify the requirements of hexosamine biosynthetic pathway (HBP) an

113 While these findings do not remove the requirement of high temperature toward bulk silica elect

114 within the range of 20-60 ppm, far below the requirements of high-resolution functional devices.

115 were classified into groups according to the requirement of hospitalization and surgical intervention

116 thod can be easily modified according to the requirements of host plant species and applied to a wide

117 intense research interest, but the metabolic requirements of HSCs and their adaptations to their nich

118 However, direct genetic evidence for a requirement of hyaluronan in palate development is still

119 ution experiments were performed to test the requirement of IL-4 receptor alpha (IL-4Ralpha) signalin

120 e RNAseq findings by establishing the causal requirement of intact CREB function specifically within

121 The requirement of intron 2 for high-level beta-globin expre

122 al stay (16.0 vs 8.16 d; p < 0.001), greater requirement of invasive mechanical ventilation (70% vs 2

123 lipid mutants in dissecting the phospholipid requirements of ion channel complexes.

124 accumulation of iron in healing wounds and a requirement of iron for effective repair.

125 tent with the estimated pO(2) > 0.1-0.25 PAL requirement of large, mobile and predatory animals durin

126 at characterises the combined food and water requirements of large herbivores.

127 ry systems fulfilled the caloric and protein requirements of Late Holocene pre-Columbian populations

128 The requirement of Leishmania to survive in changing environ

129 tations that can be generalized, a paramount requirement of linguistic rules.

130 ctronic device applications as the stringent requirement of low defect density is eased.

131 s roll-to-roll (R2R) processing, may fulfill requirements of low-cost disposable devices.

132 modification of PAI-1 confirmed an essential requirement of lysine residues in PAI-1 for the interact

133 environmentally driven divergent functional requirements of males and females has important implicat

134 ittle is known about differential functional requirements of males and females in their natural habit

135 gen unloading to meet the distinct metabolic requirements of mammalian tissues for oxygen.

136 In this review, we start with the requirement of material properties for high performance

137 antiferromagnetic devices is limited by the requirement of material-specific constraints.

138 oped WFHE along with a summary of imperative requirements of material properties, sensor capabilities

139 s a materials conundrum owing to conflicting requirements of materials attributes at the electrode su

140 he mechanism of EGFR activation revealed the requirement of matrix metalloproteinases (MMPs), EGFR li

141 The CL requirement of MCU is evolutionarily conserved with loss

142 The requirement of mechanical ventilation and vasopressive d

143 Organ Failure Assessment score, and with the requirement of mechanical ventilation or/and vasoconstri

144 To date, the requirement of MELK in cancer remains controversial, and

145 ersy, to provide commentary on the purported requirement of MELK in cancer, and to emphasize the need

146 ranges from weeks to months, meets the time requirement of mesozooplankton to develop.

147 redox cofactor has only been limited to the requirement of mft genes for ethanol assimilation in Myc

148 We provide genetic evidence for a requirement of mitochondrial respiration in vascular end

149 , a perspective is given on how to frame the requirements of MNW-encapsulant hybrids with reference t

150 ability, and result provenance are essential requirements of modern microbiome research.

151 However, a requirement of MT minus-end-binding proteins in dendrite

152 on flame ionization detection eliminated the requirement of multilevel and multicompound calibration,

153 dingly, open syntaxin partially bypasses the requirement of Munc13 but not Munc18 for liposome fusion

154 ecific interactions illustrates the absolute requirement of N-sulfate groups vicinal to the epimeriza

155 The SAR outcome has confirmed the requirement of near planar and linear conformation of th

156 Our screen defines nucleosome surface requirements of nearly 300 nucleosome interacting protei

157 More recently, to meet the requirement of new types of displays such as organic lig

158 We focus on mission requirements of night shift work, sustained operations,

159 The key requirement of NMP is to provide an environment that is

160 f simultaneously achieving the contradictory requirements of non-volatility and fast, low-voltage (lo

161 an be designed to simultaneously fulfill the requirements of nonlinear wave-front shaping and quasi-p

162 , a comprehensive view on the regulation and requirements of Notch signaling is needed.

163 In conclusion, these findings underscore the requirement of O-GlcNAcylation during pancreas developme

164 about the nature of work (e.g., the dynamic requirements of occupations), lack of empirically inform

165 ure methods were considered, but few fit the requirement of odorless reagents.

166 ations are recommended for estimating energy requirements of older adults.

167 azaPip residues to study the conformational requirements of opioid and cluster of differentiation 36

168 ceeds in pure aqueous conditions without the requirement of organic cosolvents or photocatalysts, is

169 The metabolic requirements of osteoblast differentiation and mineraliz

170 intermediate-layer neurons is matched to the requirements of output neurons.

171 The requirement of patients on dialysis for regular treatmen

172 ntions (eg, psychotherapy) distinct from the requirements of patients with neurodegenerative cognitiv

173 f the body contain molecular clocks, but the requirement of peripheral clocks for rhythmicity and the

174 The host factor requirements of phages and mechanisms of mutational phag

175 me profiling in MM lines also demonstrated a requirement of PHF19 for optimal silencing of PRC2 targe

176 arious MM models, we demonstrated a critical requirement of PHF19 for tumor growth in vitro and in vi

177 We demonstrate the requirement of PI3Kgamma for TLR9-induced inflammation i

178 Kras(G12D) ;PKCe(-/-) mice) demonstrated the requirement of PKCe for Kras-driven lung tumorigenesis i

179 pairing region of some sRNAs eliminated the requirement of PNPase for their stability.

180 To meet the requirements of potential applications, it is of great i

181 Computational simulations predicted the requirement of PP2A-B55/SUR-6 regulation of nuclear size

182 B/c mouse infection model, demonstrating the requirement of ppiB for in vivo disease dissemination an

183 Therefore, meeting the requirements of practical applications still remains uns

184 ge, and the biosensor is hard to satisfy the requirements of practical applications.

185 on of versatile carbonyl groups, without the requirement of pre-functionalized substrates.

186 carbocyclic adducts, thereby precluding the requirement of preactivated alkynes.

187 primary outcomes were postoperative IOP and requirement of pressure-lowering medications.

188 , and interventions reconciles the different requirements of prevention cascades, providing a unifyin

189 Our study proposes a mechanism for the requirement of PRMT5 for leukemia cell survival and prov

190 nome-scale screening is limited by the usual requirement of producing sufficient amounts of each prot

191 n Europe and was monitored by the ecological requirements of Progonomys.

192 atile tool to study the spatial and temporal requirement of proteins in zebrafish.

193 According to the requirements of provincial regulation, 21,525 have been

194 Macropinocytosis supports the metabolic requirement of RAS-transformed pancreatic ductal adenoca

195 ition, we have determined the minimal domain requirement of RBM47 needed for activity.

196 approach as well as its adaptability to the requirements of real-world clinical practice, the latest

197 These results indicate the requirement of RelA-dependent inducible hepatoprotection

198 for membrane fusion, which is in contrast to requirements of related class III fusion proteins, inclu

199 0.004), with a significant reduction in the requirement of renal replacement therapy (RRT; 56.6% vs.

200 nt confound of conscious perception with the requirement of reporting it.

201 ods cannot simultaneously meet the stringent requirements of resolution, throughput, and uniformity o

202 orisation measures may include only standard requirements of risk management and pharmacovigilance pl

203 ods have some drawbacks like time-consuming, requirement of sample pre-treatment, high cost instrumen

204 neck in a gate-model quantum computer is the requirement of several rounds of quantum state preparati

205 na fide TREEs, we tested the sufficiency and requirements of several sequences in stable transgenic l

206 from the stamens to the stigma, an essential requirement of sexual reproduction in flowering plants.

207 eir migration into lymph nodes, indicating a requirement of sialylated O-glycans for proper trafficki

208 molecular architecture to the space-filling requirements of six possible bicontinuous cubic phases,

209 Calculations of the energy requirements of small pelagic fish and jellyfish stocks

210 nvironment in which capsids assemble and the requirement of some capsids for disassembly before genom

211 als engineering that has been limited by the requirement of sophisticated devices, and special skills

212 non-electrochemical analytical tools without requirement of sophisticated instrumentation have become

213 underprivileged global population due to the requirements of sophisticated instrumentation and traine

214 highlights "understanding the exact habitat requirements of Southern Ground-hornbills" as a knowledg

215 While there is no indication for a requirement of Sox10 in the specification of the mammary

216 olymerase chain reaction (PCR) tubes with no requirement of specialized devices, columns, or instrume

217 se certain issues including their high cost, requirement of specialized ligands, sensitivity to air a

218 methods have certain limitations such as the requirement of specific capture reagents, limited mass r

219 omoter selectivity by RNA polymerase and the requirement of specific metal cofactors for maximal RNA

220 sign of hollow nanostructures to fulfill the requirements of specific applications and simultaneously

221 n of STIM1 with that of STIM2 eliminated the requirement of STIM2 for NFAT1 activation.

222 Given that a composition meets basic requirements of stoichiometry, steric demands, and charg

223 To define the structural requirements of subglutinols for immunomodulatory activi

224 A key requirement of such a biosensor is the simple and direct

225 ns an unmet challenge owing to the different requirements of such bioassays.

226 nto the potential origin and differentiation requirements of T(FH1) cells.

227 The requirement of TARS2, but not cytoplasmic threonyl-tRNA

228 is well equipped to meet the precision flow requirements of TDA.

229 hromatin immunoprecipitation, are limited by requirement of TF-specific antibodies and provide only e

230 licular helper (Tfh) differentiation and the requirement of Tfh cells as the specialized subset of CD

231 The reason for the emergence and strict requirement of the additional initiation factor Bdp1 in

232 uence satisfy the protospacer adjacent motif requirement of the Cas9 domain and that the target nucle

233 RMT5-specific inhibitor, we demonstrated the requirement of the catalytic activity of PRMT5 for the s

234 rrent limitations of biosensors, such as the requirement of the cells for a liquid growth matrix, con

235 at least in part due to the high temperature requirement of the characterized family members.

236 ose that this cooperativity is the intrinsic requirement of the CRISPR integration complex formation.

237 no correlation between the activation energy requirement of the different species and their molecular

238 useful for studying DNMT3A(R882mut), shows a requirement of the dominant-negative effect by DNMT3A(R8

239 susceptibility testing (DST) is an important requirement of the End TB Strategy.

240 is essential in living cells, the functional requirement of the full CTD for the control of Pol II ac

241 However, because of the steric requirement of the Goldschmidt tolerance factor rule, it

242 ties under study without the prior knowledge requirement of the reaction system.

243 beverage and, consequently, to confront the requirement of the Specialty Coffee Association regardin

244 This conclusion holds even for the relaxed requirement of the target only approximately attaining t

245 sure to decouple the mechanical and chemical requirements of the adsorbent, one design concept protot

246 edema, and metabolically supports the energy requirements of the brain.

247 the tissue of origin can alter the metabolic requirements of the cancer stem cell population.

248 e levels of myosin stacks matching the force requirements of the cell.

249 re different from the more familiar clinical requirements of the Clinical Laboratory Improvement Act

250 well as retreatable, which complies with the requirements of the conservation ethics.

251 onally designed to match the local transport requirements of the device architecture.

252 ch, understanding the differential metabolic requirements of the diverse cells that comprise an immun

253 The different metabolic requirements of the diverse cells that constitute an imm

254 odology was developed in compliance with the requirements of the European Pharmacopoeia for the quant

255 icy-making in the context of the legislative requirements of the European Union's Food Information fo

256 Here, we demonstrate dosage-dependent requirements of the exon junction complex component Mago

257 r has to be tuned to account for the special requirements of the experiments.

258 tus was probably triggered by the functional requirements of the feeding apparatus.

259 d supply capable of providing for the growth requirements of the fetus in later pregnancy, without ex

260 on in coffee, maintaining the manufacturer's requirements of the finished product.

261 most studies could not meet the performance requirements of the high-priority target product profile

262 tion of maternal macronutrients to match the requirements of the lactating mammary gland.

263 structure and satisfies all hydrogen-bonding requirements of the ligand.

264 for generation of energetic and biosynthetic requirements of the MDV infection, while glucose is used

265 nciples conserved with yeast to the specific requirements of the more complex metazoan cells.

266 Our findings define molecular and temporal requirements of the nonphotopic or photopic visual cycle

267 developing predictive equations to meet the requirements of the older population with consideration

268 -Pd(L)-Ge] complex, as well as of the steric requirements of the phosphine ligand.

269 se adaptations to the specific physiological requirements of the respective organism might aid in the

270 enerate sufficient ATP to satisfy the energy requirements of the rest of the cell in addition to its

271 Given the tremendous metabolic requirements of the retina and photoreceptors in particu

272 ight require tailoring based on the specific requirements of the study at hand.

273 a pH range to accommodate the conflicting pH requirements of the substrate and enzymes without the ne

274 tailors the implementation of effort to the requirements of the task at hand.

275 define the molecular basis of the substrate requirements of these enzymes, including the prototypic

276 onal regulation of Hoxd genes illustrate the requirement of this regulatory topology for the precise

277 by "omics" approaches is lagging behind the requirements of this field, especially when it comes to

278 However, the computational requirements of this kind of model could represent a lim

279 The minimal requirements of this method make it additionally accessi

280 that shapes these changes and the functional requirements of this population in TLS development are u

281 The requirements of this signal conduction remain elusive.

282 sted the accuracy, sensitivity, and resource requirements of three top metagenomic taxonomic classifi

283 very good atom economy, low E-factor, and no requirement of toxic solvents and chromatographic purifi

284 cticality of such systems is hindered by the requirement of toxic, flammable organic electrolytes or

285 he cluster at 29 degrees C combined with the requirement of transcription of euchromatic homologous s

286 ring early seed germination, even before the requirement of transcription.

287 Here we demonstrate a striatal-specific requirement of transcriptional regulator Nolz1 in establ

288 red with premature patients with ROP without requirement of treatment (group 1), although there is a

289 This study aimed to investigate the chemical requirements of triterpenoid glycosides within a new bin

290 the planar cyclo-P(4) group is unique in its requirement of two additional electrons to achieve aroma

291 ide a framework for understanding the target requirements of type III systems as a whole.

292 lecular dynamics underlying the higher water requirements of unrefined doughs, often associated with

293 ang1 and Vangl2 mouse alleles to examine the requirement of VANGL family members in the murine mammar

294 ha was not required for the increased CDK4/6 requirement of VHL(-/-) ccRCC cells.

295 mpared with controls in vivo, confirming the requirement of vimentin for establishment of infection.

296 attention networks, in accordance with task requirements of visuo-spatial reasoning.

297 to the detection limit on protein size, the requirement of volatile buffers, and the necessity for s

298 The additional protein requirements of well-nourished Indian pregnant women for

299 the electricity consumption for the process requirements of WWTPs.

300 ed in winter, which may be due to the strong requirement of zeaxanthin for rapid thermal dissipation