ライフサイエンスコーパス: requisite

1 f oligosaccharides and glycoconjugates are a requisite.

2 em cyclization that directly establishes the requisite 1,3-trans stereochemical arrangement on one ri

3 Suzuki coupling/dimerization to generate the requisite 2,2'-biaryl linkage.

4 A requisite 3' maturation step leads to triplex formation

5 (e.g. RecBCD, AddAB or AdnAB) generates the requisite 3' single-strand DNA substrate for RecA-mediat

6 by ribozymes and a trihelix-forming RNA with requisite 5' and 3' duplications, do not produce circles

7 loying trinuclear [In3(mu3-O)(O2C-)6] as the requisite 6-connected trigonal-prism and purposely made

8 t-butyl alk-3-ynoate substrates that possess requisite acidic propargylic C-H bonds.

9 omplexity using a single catalyst, where the requisite activation modes are sequentially exploited as

10 remophyte offers a framework to identify the requisite adjustments of genomic architecture and expres

11 dLight1 offers high molecular specificity, requisite affinity and kinetics and great sensitivity fo

12 bination with controlled installation of the requisite alkene geometry.

13 The requisite alkenyl triflates can be made separately or pr

14 The requisite alkenylaluminum reagents are synthesized with

15 methylsilyl)ethyl sulfoxides to liberate the requisite alkyl sulfenate anion intermediates.

16 into a ligand-binding domain, generating the requisite allosteric coupling, remains a rate-limiting s

17 nhanced CLIP (eCLIP) protocol that decreases requisite amplification by approximately 1,000-fold, dec

18 but primary age-related tauopathy lacks the requisite amyloid plaques central to Alzheimer's disease

19 -methylimidazolium dicyanamide) provides the requisite and polarizing medium to realize the detection

20 However, the activation requisites and regulatory cues governing T-bet and CD11c

21 when T-cell responses were high or when the requisite antibody titers had declined.

22 Subsequent conjugate addition of the requisite antipode of lithium N-benzyl-N-(alpha-methylbe

23 with EBV-related lymphocryptovirus (LCV) are requisite APCs for MHC-E-restricted autoaggressive effec

24 ility, structural knowledge of the system is requisite, as is an explicit recognition that most causa

25 n to the matrin-3 network, bypassing the pre-requisite association with beta-catenin and Satb1 otherw

26 ia are specialized compartments that produce requisite ATP to fuel cellular functions and serve as ce

27 The requisite base and metal open site are masked in the res

28 d, role, and more robust prospective data is requisite before drawing overarching conclusions.

29 Considering the requisite biological and technical factors for eliminati

30 argue that current models do not include the requisite biological detail to completely predict functi

31 rovide further insights into the kinetic and requisite biophysical characteristics of acutely synapto

32 nk to perform coevolutionary analysis of two requisite biosynthetic proteins.

33 eriments have suggested the existence of the requisite broken-symmetry phase in the high-T(c) cuprate

34 The requisite building blocks could be prepared from feedsto

35 In addition, approaches to install the requisite butenolide moiety at the C17 position are disc

36 energy ring-protonated tautomer allowing the requisite C-C bond cleavage.

37 consequence of blocking the interaction of a requisite c-MYC IRES trans-acting factor, heterogeneous

38 er capable of operating at 100 Hz and allows requisite C-trap inject time during MSI to be reduced to

39 ermediate with formaldehyde to introduce the requisite C16 hydroxymethyl group.

40 iodoallylation is adopted to incorporate the requisite C17-C19 functionality in a stereoselective man

41 rearrangement of a vicinal diol to give the requisite carbonyl, followed by intramolecular Friedel-C

42 dily available N-substituted amides or their requisite carboxylic acids or acid chlorides have been u

43 phoid-primed multipotent progenitors, as the requisite CD11a-dependent precursor for lymphocyte devel

44 ns to which ligands can bind and recruit the requisite cellular components.

45 tide backbones can intrinsically undergo the requisite chain expansion in aqueous solutions with high

46 leading to a beta-lactone incorporating the requisite cis-fused 2-azadecalin moiety and also setting

47 be swayed by the fact that workers with the requisite clinical microbiology skills are becoming more

48 e (SLO), it has remained unclear whether the requisite close tunneling distance occurs through an unu

49 ically active surface area (ECSA), lower the requisite CO2 reduction overpotential by hundreds of mil

50 ssociated accessory proteins that supply the requisite cofactors and substrates.

51 ts the location in the human brain where the requisite combination occurs.

52 I and transcript release factor (PTRF) is a requisite component of caveolae, small plasma membrane i

53 General anesthesia has been the requisite component of surgical procedures for over 150

54 A requisite component of the mechanism is that the solute

55 Two requisite components of timely access are (1) the abilit

56 These results support the notion that the requisite coupling between Cl(-) and proton transport oc

57 aPI-containing cell will lyse, releasing the requisite crop of SaPI particles as well as a greatly di

58 ry producers of type I interferons (T1-IFN), requisite cytokines for survival, following ECTV infecti

59 work shows that sensory input can induce the requisite decrease in across-individual variability even

60 oth Huwe1 and USP10 appears to fine-tune the requisite degradation of TBP during myogenesis.

61 al research are cultured adherently, and the requisite detachment prior to biochemical analysis might

62 coupled to analysis techniques that lack the requisite detection power.

63 Y(2) receptors in RTN smooth muscle cells as requisite determinants of respiratory chemoreception.

64 ct with regeneration of ruthenium(0) and the requisite dione.

65 Our model predicts that the requisite DMC and therefore necessary level of transferr

66 N-terminal fragment (C0C3) must possess the requisite domains needed to bind specifically to the thi

67 old hydrogen bond acceptor in templating the requisite double-eight rings (d8r) of the mer framework.

68 thelial IL-17 signaling axis is a potent and requisite driver of PanIN formation.

69 Retinoic acid (RA) is a requisite driver of spermatogonial differentiation and e

70 gested that interleukin (IL)-4 and IL-13 are requisite drivers of atopic dermatitis, evidenced by mar

71 Thus, the retrosplenial cortex has the requisite dynamics to serve as an intermediary between b

72 DA assembly and ciliary vesicle docking, two requisite early steps in cilia formation.

73 Following 80S assembly, the requisite eEF2-mediated translocation results in an unst

74 To achieve the requisite efficiency, we need a materials discovery and

75 er binds in contact with SAM and donates the requisite electron for the reductive cleavage of SAM to

76 sed in catalytic cross-coupling, possess the requisite electronic and steric attributes to allow them

77 system from Escherichia coli as a source of requisite electrons.

78 A breaks that is entirely uncoupled from its requisite engagement in DNA replication.

79 untries, with 78% of respondents reporting a requisite entrance examination.

80 of a wound, or progression of a carcinoma, a requisite event is collective epithelial cellular migrat

81 yte-macrophage colony-stimulating factor are requisite factors in the tumor that, working through the

82 Telomere length maintenance is a requisite feature of cellular immortalization and a hall

83 n particular, have been elusive due to their requisite finely tuned long-ranged hoppings.

84 By ejecting PKA, PINK1 ensures the requisite fission of damaged mitochondria for organelle

85 A safe and sufficient blood supply is requisite for a functional surgical system.

86 3]dendralenes and deciphers their structural requisite for a successful diene transmissive Diels-Alde

87 note, phosphorylation of the ABCDE sites is requisite for activation of the Artemis nuclease that as

88 Correlates of immunologic protection requisite for an efficacious herpes simplex virus 1 (HSV

89 ation, and cell-cell adhesion, which are all requisite for angiogenesis.

90 Mechanistically, betaIV-spectrin is requisite for ankyrin-dependent targeting of calcium/cal

91 mination of the mutant protein will be a pre-requisite for any curative therapeutic strategy.

92 High quality DNA is the pre-requisite for any molecular biology study.

93 This report also suggests that trypsin is a requisite for AP only because it causes release of cathe

94 s studied, mTOR expression and activity were requisite for autophagy, a paradigm countering the curre

95 eneration of B-cell receptors, which are pre-requisite for B-cell progenitor survival.

96 Is inflammation the primary requisite for Breg cell differentiation?

97 hylated to 3-methylcytosine (m(3)C) as a pre-requisite for C-to-U deamination.

98 ion provides the precision and dynamic range requisite for closed-loop neuronal control, but no appro

99 ties, and assess how host preference - a pre-requisite for codependency - changes across spatiotempor

100 binding sites, the proline-rich region is a requisite for compaction of the microtubule binding regi

101 As a pre-requisite for constant growth, plants produce vascular t

102 revention of kidney fibrosis is an essential requisite for effective therapy in preventing chronic ki

103 ation of attaching and effacing (AE) lesions requisite for EHEC colonization.

104 driven by ultra-short laser pulses is a pre-requisite for envisaged low-power spintronics combining

105 ase 2 (Shp2) encoded by the Ptpn11 gene is a requisite for ErbB2-induced tumorigenesis.

106 ional units) is achieved, representing a pre-requisite for exploring the underlying physics.

107 The combination with pDCs and rapamycin is requisite for Flt3L/antigen-induced Treg induction becau

108 abilization of Est1 binding to TLC1 is a pre-requisite for formation and nuclear localization of the

109 ain array, proper cellular localization is a requisite for full activity and is mediated by a C-termi

110 ormation of large GAC oligomers is not a pre-requisite for full enzymatic activity.

111 , which is necessary for NO production, is a requisite for fungal clearance in the hypodermis.

112 st time the existence of a developmental pre-requisite for highly efficient splicing during Drosophil

113 ith TANK-binding kinase 1 (TBK1), which is a requisite for IFN-1 induction in response to DNA.

114 e fundamental premise that muscle anoxia was requisite for increased muscle and blood [La(-) ].

115 cogenides provide further degrees of freedom requisite for information processing and spintronics.

116 emonstrate that mRNA docking per se is a pre-requisite for initiating Ire1's RNase activity and, henc

117 the complete evidence base that is now a pre-requisite for instituting screening.

118 ne of the peptidoglycan on one side is a pre-requisite for its recognition and turnover by Pgp3.

119 ations in environmental nutrient levels is a requisite for life.

120 ting the cytoskeletal reorganization that is requisite for lytic granule release.

121 ects on the formation of lamellipodia, a pre-requisite for migration using human lung microvascular e

122 s study identifies a previously unrecognized requisite for myeloid cell STAT3 in the activation of my

123 transients during development serve as a pre-requisite for normal adult behavior.

124 brane-bound ion channels and transporters is requisite for normal cardiac function.

125 ant for predator detection, as well as a pre-requisite for normal social functioning and more complex

126 that KLF4 binds to, cooperates with, and is requisite for optimal function of the estrogen-related r

127 st of the Wnt/beta-catenin signaling pathway requisite for osteoblast development and activity.

128 cient Dvl plasma membrane recruitment, a pre-requisite for PCP activation.

129 This would be a pre requisite for potential anticipation, either by electron

130 vealed that stromal, not neoplastic, TLR7 is requisite for R848-mediated responses.

131 cute extinction of naive pluripotency, a pre-requisite for rapid progression from preimplantation epi

132 the action of biological molecules is a pre-requisite for rational advances in health sciences and r

133 and suggest that Cat-domain degradation is a requisite for resetting SPS-sensor signaling.

134 that nuclear accumulation of SAPKs is a pre-requisite for SAPK-dependent gene expression, and reveal

135 ctions between the nucleobases, an essential requisite for self-assembly.

136 22, 23] exhibit periods of quiescence, a pre-requisite for sleep-like states, prompting us to ask whe

137 more, sight of the hands was a necessary pre-requisite for somatosensory remapping at 10 months.

138 pful for insight into its function, but is a requisite for such insight.

139 on specifically in tumours, which is the key requisite for the acquisition of gain-of-functions activ

140 n of MRN/ATM signaling which appears to be a requisite for the activation of MDC1-dependent MRN compl

141 the severity of gas exchange impairment is a requisite for the characterization of the syndrome and t

142 that removal of DNA methylation is not a pre-requisite for the creation of accessible chromatin at ac

143 damage or tissue injury may be an essential requisite for the development of allergic sensitization

144 release over extended time periods is a pre-requisite for the development of desired immune response

145 cal feature of diabetic kidney disease and a requisite for the development of end-stage renal disease

146 Expression of Tcf7/Tcf1 was requisite for the efficacy of diverse immunotherapies, h

147 The inter-domain synergism was pre-requisite for the efficient degradation of cellulose in

148 of afferent growth cones is an essential pre-requisite for the identification of synaptic partner neu

149 f proteins that synthesize short RNA primers requisite for the initiation of DNA replication.

150 This is a pre-requisite for the second phase, in which the Par complex

151 The combination of these activities appears requisite for the utilization of WTA as a phosphate rese

152 terestingly, NMDA receptor function is not a requisite for these short-term spatiotemporal memory pro

153 Requisite for this activity was a TOG5-specific N-termin

154 making subtle postural adaptations that are requisite for this task.

155 erentiation of the malaria parasite is a pre-requisite for transmission from humans to the mosquito v

156 infection of monocytes by HTLV-1 is likely a requisite for viral persistence in humans.

157 single gating charge per channel subunit is requisite for voltage, temperature, and osmotic swell po

158 e3-mediated silencing of structural genes as requisite for zebrafish heart regeneration and suggests

159 transcription factor iroquois 2a (irx2a) is requisite for zebrafish nephrogenesis.

160 tion of treatment effect (PTE) explained are requisites for a suitable surrogate end point.

161 an be chemically engineered to fit the above requisites for conditional gates with no need of local c

162 Requisites for development of this highly mineralized ti

163 teaching or proto-language may have been pre-requisites for the appearance of Acheulean technology.

164 t Ca(2+)-dependent contractions generate the requisite force to physically deform the innermost layer

165 tide synthesis was employed to elaborate the requisite fragments, with full peptide construction via

166 It has since been found to have a requisite function in differentiation initiation in many

167 to a transient nitrosoalkene to install the requisite functionality and configuration at the C7 posi

168 terizing myocardial infarction (MI), but the requisite gadolinium infusion is estimated to be contrai

169 similar in their ability to accommodate the requisite geometric constraints during protein binding.

170 Yet the synthesis of the requisite geometrically defined enamides remains problem

171 While the requisite glycan epitopes needed to bind galectin-3 have

172 developing "heuristics" to define structural requisites governing activity at TLR7 and/or TLR8.

173 or progression, cancer cells can produce the requisite growth- and invasion-promoting factors and can

174 Providing clinicians with the requisite health status data on which to base treatment

175 Multidisciplinary medical vigilance and the requisite health-care infrastructure are imperative to e

176 lls (Tfh), a subset of CD4+ T cells, provide requisite help to B cells in the germinal centers (GC) o

177 the use of UV-active photocatalysts for the requisite high-energy hydrogen atom abstraction event.

178 to be unsuitable for the introduction of the requisite hydroxyl groups at carbons 4a and 12a.

179 ue for achieving transplantation without the requisite immunosuppression.

180 underpinning disease progression will prove requisite in developing new treatments and cures.

181 rates without extended pi-systems, a typical requisite in many C-O bond-cleavage reactions.

182 d their associated metabolites, is a crucial requisite in the discovery and development of these mole

183 These findings suggest that the lOFC sends requisite input to the BLA, via monosynaptic connections

184 according to the standards, establishing the requisite internal compliance bureaucracies has markedly

185 The requisite intersystem crossing in the open-shell structu

186 ted due to the relatively slow nature of the requisite ion-molecule reactions that result in long ion

187 Efforts and progress toward eliminating the requisite large excess of LiCl are discussed.

188 those of the dilithium salts but without the requisite large excesses of inorganic salts (LiCl) or ma

189 As antibodies with loops of requisite length are created through uncommon recombinat

190 disease-causing pathogens by generating the requisite ligand patterns on customized DNA nanoarchitec

191 neutrophils (PMNs) and epithelial cells are requisite lines of communication during mucosal inflamma

192 Drosophila wings, but hard evidence for the requisite long-range action has only now come from two n

193 ons have been able to form galaxies with the requisite luminosities, but have otherwise been unable t

194 selection, demi-chiral proteins possess the requisite marginal biochemical function and structure of

195 eading depolarizations are hypothesized as a requisite mechanism and clinical marker of infarct devel

196 esearch support, commitment to providing the requisite mentoring, access to instrumentation, and stat

197 ng from the methyl cholate core provided the requisite modification in the block copolymer interfacia

198 uch antibodies are generated and acquire the requisite molecular characteristics for neutralization.

199 , the bulk plastic deformation triggered the requisite molecular mobility of the polymer chains, caus

200 ion by rendering the axes susceptible to the requisite molecular remodeling.

201 thioether motif favor the generation of the requisite mono(amine)-Pd(II) intermediate, thus enabling

202 receives an input beyond that boundary, the requisite mRNAs for local translation and plasticity may

203 on pathways do not require transit through a requisite multipotent or bipotent megakaryocyte-erythroc

204 The process consists of formation of the requisite N-(2-nitrobenzyl)(tritylthio)alkylamine, subse

205 although the precise role for NOTCH and the requisite nature of BMSCs following fracture is unknown.

206 BLs respectively, as a pathway to access the requisite net-cBUs.

207 The development of the requisite nitrogen- and oxygen-based ligand libraries la

208 interactions facilitate the transduction of requisite Notch signals from the somite to the precursor

209 ls and to establish curricular standards and requisite nutrition and physical activity competencies i

210 itions required for the rearrangement of the requisite O-aryl carbamothioates often leads to decompos

211 which work is done on the environment - the requisite of a molecular machine - is more likely than c

212 Accurate genotype calling is a pre-requisite of a successful Genome-Wide Association Study

213 The requisite of additional surgery after locally resected T

214 udy in the quantum regime is hindered by the requisite of ground state cooling.

215 Understanding the structural and energetic requisites of ligand binding toward its molecular target

216 irst to identify microRNA 486 (miR-486) as a requisite oncomiR and credible therapeutic target in mye

217 e as yet to provide such an implant with the requisite optical quality or ability to change the focus

218 ic acid can easily be coupled to prepare the requisite organic strut with four metal-binding sites in

219 ignaling, which was recently identified as a requisite PDGF-gradient-sensing pathway, with the goal o

220 The requisite peptides with heterogeneous backbones were pre

221 the E1 glycoprotein and therefore block the requisite pH-dependent fusion of viral and host membrane

222 ol lactone-based C-ring, which possessed the requisite pharmacophores for binding to protein kinase C

223 thesis of 2a is amenable to formation of the requisite phosphoramidite for solid-phase oligonucleotid

224 s is an emerging strategy for achieving this requisite physical parameter.

225 addition adducts are then transformed to the requisite polysubstituted BCP compounds via a range of s

226 This suggests that the requisite practice for durable perceptual learning is in

227 thod reduces analysis time while maintaining requisite precision and detection limit.

228 macrophages in mouse models and provides the requisite preclinical information to translate the targe

229 limited by the availability of bioinks with requisite printability, cytocompatibility, and bioactivi

230 ified L can copy synthetic RNA that contains requisite promoter sequences.

231 hat gamma-actinorhodin possesses many of the requisite properties of an antibacterial drug, displayin

232 may impair memory consolidation by impairing requisite protein translation in the VHIPP.

233 zyme activity, although the mechanism of the requisite pyridine/dehydropiperidine synthase remains to

234 e-directed functionalization at C12 to set a requisite quaternary center.

235 ts and elevated temperatures to generate the requisite radical species.

236 cells transfected with cDNAs encoding three requisite receptor subtypes: alpha7-nAChR, alpha4beta2-n

237 vascular smooth muscle cells (SMCs), and the requisite reducing systems that regulate cellular NO dec

238 ization sequence to furnish four of the five requisite rings and three of the five stereocenters in t

239 ent eosinophilic dermatitis to demonstrate a requisite role for basophils.

240 velopmental Cell, Arraf et al. (2016) find a requisite role for bilaterally symmetrical BMP signaling

241 Overall, we reveal a requisite role for IRS4(PVH) neurons in PVH-mediated ene

242 Taken together our studies demonstrate a requisite role for mesodermal integrin alpha5beta1 in si

243 While phagocytic cells have a requisite role in the response to ECTV, the requirement

244 lymphoid irradiation, host CD8(+) DCs play a requisite role in tolerance induction through interactio

245 Reduced protein level of a requisite scaffolding protein of the initiation complex,

246 Reduced protein level of a requisite scaffolding protein of the initiation complex,

247 e array of targeting subunits to achieve the requisite selectivity.

248 In providing cancer aftercare there is a requisite shift to proactive care, supported self-manage

249 lation did not prevent the generation of the requisite side chain fragmentation w ions.

250 This organelle and its requisite signaling protein, PC1, are required for criti

251 ion to ensure that future graduates have the requisite skills necessary to manage these critically il

252 fcu-MOF pores permits the achievement of the requisite sorbate cutoff, ideal for selective adsorption

253 nic excitations, as it uniquely combines the requisite spatial and temporal resolution, making it ide

254 a screen-printed carbon electrode to obtain requisite stability and selectivity of the measurement.

255 Preparation of requisite starting materials, method definition, dipole

256 xes on the surface of professional APCs is a requisite step in an effective immune response following

257 moiety of rhodopsin is an extremely slow but requisite step in the restoration of the visual pigment

258 calcium-dependent calpain, CAPN1, which were requisite steps for induction of apoptosis in MDS cells

259 intensive processes with many composite and requisite steps.

260 Crucially, these complexes feature the requisite strong field ligands to enable emission for op

261 Our measurements confirm the requisite strong spin-orbit coupling and low-temperature

262 protein binding partners in facilitating the requisite structural changes is not well understood.

263 ge rigid-body motion almost certainly impede requisite structural rearrangements during the fusion pr

264 spectromicroscopy (TER-SM)(3,4) reaches the requisite sub-molecular spatial resolution(5), confirmin

265 neuronal glycolysis was sufficient to supply requisite substrate.

266 The requisite substrates for the vinyl acetal rearrangement

267 ing mechanisms governing polar growth or the requisite suite of factors that direct polar growth.

268 is sacrificed during catalysis to supply the requisite sulfur atoms, rendering the protein inactive f

269 ral networks and the TKO measure provide the requisite targets for the search for effective predictiv

270 Single-photon detection is a requisite technique in quantum-optics experiments in bot

271 can propagate across neural systems without requisite templated misfolding, but the absence of endog

272 ation of many neurons in a network, with the requisite temporal precision to simulate accurate neural

273 undergoes a cascade reaction to install the requisite tetracyclic ring system.

274 valent iodine or heavy metals to provide the requisite thermodynamic driving force for overcoming aro

275 tain multiple [4Fe-4S] clusters, to form the requisite thioether bridge between a cysteine and the al

276 from other signals, including speech, a pre-requisite to avoid false alarms in normal vocal communic

277 at the density-functional theory level is a requisite to form the mixed disulfide intermediate.

278 More selective inflammatory tracers are requisite to identify the diffuse local inflammation in

279 that mesenchymal-to-epithelial transition is requisite to initiate SMCs reprogramming into vascular p

280 Pharmacokinetic data are a pre-requisite to integrated implementation of large-scale ma

281 A pre-requisite to medicinal chemistry optimisation programmes

282 etween DNA loops of different centromeres is requisite to recapitulate experimentally determined corr

283 For successful treatments, however, it is requisite to rigorously optimise oligonucleotide chemist

284 those pathways on a molecular level is a pre-requisite to specifically target the peptide's tertiary

285 atients signed written informed consent as a requisite to undergo PET/CT examination.

286 Mg solvation structure in the electrolyte is requisite to understand the transport behavior of Mg ion

287 s interactions and a network approach may be requisite to understanding demographic responses to envi

288 to indeterminacy during evolution was a pre-requisite to vascular plant diversification, but mechani

289 Thus, blood glucose monitoring is a requisite tool in the management of diabetes mellitus.

290 f ribosome assembly in vivo and provides the requisite tools to characterize additional assembly path

291 ted in a number of systems that recreate the requisite topological conditions.

292 Forkhead box (FOX)P3 is a requisite transcription factor for the development and m

293 stantial efforts are now underway to support requisite transformative changes.

294 ate reagent to expedite the synthesis of the requisite trifluoromethyl-substituted alkene starting ma

295 enturous ring-closing metathesis to form the requisite trisubstituted (8E)-alkene in the 12-membered

296 from Phaeodactylum tricornutum, imports the requisite unnatural triphosphates from its medium and th

297 icant impediment to improvement has been the requisite use of conventional destructive mechanical tes

298 Similarly, these structural requisites were found in store-operated Orai channels.

299 en both genotyped and phenotyped are the key requisite when aiming for high prediction accuracy.

300 The requisite (Z)-substituted potassium allyltrifluoroborate