ライフサイエンスコーパス: residence time

1 2) time needed to complete a run (waiting or residence time).

2 ynamically than cohesin ( 1-2 min vs. 22 min residence time).

3 the molecular interactions governing ligand residence time.

4 ion were strongly dependent on inflow pH and residence time.

5 und the core of the chemokine to prolong its residence time.

6 ptake time constant divided by the enclosure residence time.

7 actin, which is dependent upon their F-actin residence time.

8 deeper the delivery, the more prolonged the residence time.

9 and regional dynamics as a function of patch residence time.

10 t role that on-rates can play in drug-target residence time.

11 of mRNAs near the membrane, as well as their residence time.

12 undesirable biodistribution and short blood residence time.

13 the collagen matrix, and extended peritoneal residence time.

14 ly ATP-competitive and shows just a moderate residence time.

15 eaction sequence in a good yield and a short residence time.

16 arge, vegetation, river morphology and water residence time.

17 putational tools for predicting kinetics and residence time.

18 species with excellent brain penetration and residence time.

19 ing binding and kinetics, including the drug-residence time.

20 o afford the rearranged product in 22 min of residence time.

21 the transcription factor in addition to its residence time.

22 h static pressure of 93,325 Pa and for 1.5 s residence time.

23 ty, biological activity, and ligand-receptor residence time.

24 e impact on respiratory partitioning or mean residence times.

25 ation, which is associated with higher water residence times.

26 n OFRs than in ECs, due primarily to shorter residence times.

27 imulations to determine pose-specific ligand residence times.

28 found in the LMEs with the longest seawater residence times.

29 basis of the extent of current blockades and residence times.

30 grees C per 500 years result in much reduced residence times.

31 manipulation most likely by determining Cas9 residence times.

32 in) for basimglurant and mavoglurant, medium residence times (10-30 min) for AZD2066, remeglurant, an

33 (2)PO(4)/K(2)HPO(4) at -1.5 V/SHE (hydraulic residence time, ~11 s) resulted in 73, 94, and 96% DBAA

34 e presence and absence of NaCl at 3.1 V/SHE (residence time = 13 s).

35 in moderate to excellent yields with a short residence time (20 min) and mild conditions at ambient t

36 To prolong the residence time, absorption and bioavailability of a broa

37 in the limiting case but differ in how patch residence times adapt when the foraging environment is u

38 riking across-specimens differences in fluid residence times affecting humidification and warming per

39 ile pumped through heated tubing for a given residence time, after which they pass over a substrate.

40 efficacy and conformation, indicating ligand residence times among related analogs may influence rece

41 roperties, groundwater recharge, groundwater residence time and aquifer-river exchanges from few hour

42 ive diagnosis of system properties such as C residence time and attribution of global change impacts

43 bance rates and intensities have lower woody residence time and biomass.

44 heir watersheds, including morphology, water residence time and hydrology, such as the influence of L

45 Besides, the empty bed residence time and inlet load range of biofilter were se

46 s that this step lowers transcription factor residence time and non-specific collisions during sampli

47 one (CACO), that display high affinity, long residence time and pronounced selectivity.

48 ican landscape resilience over 20,000 years: residence time and recovery time.

49 The same long residence time and resistance to competition are seen wi

50 ransient binding interactions to enhance the residence time and signaling output of active RhoA to co

51 The modeled residence time and storage capacity of the aquifer indic

52 Increasing the residence time and temperature resulted in significant i

53 ensins have two essential properties: a long residence time and the ability to perform two-sided (not

54 rate that p53 acetylation modulates promoter residence time and transcriptional activity.

55 ted in the reactor increased with increasing residence time and with decreasing Ca(2+) to urea molar

56 terms of digestion efficiency at comparable residence time and, using a 3D-printed interface, be dir

57 relates with picomolar affinities, increased residence times and an absence of the peroxide productio

58 rs onto micropillars which necessitates long residence times and causes damage to clusters during rel

59 organ time-integrated activity coefficients/residence times and finally organ absorbed doses.

60 geochemical consequences of prolonged water residence times and hydrological isolation that characte

61 Notably, short residence times and long recovery times directly precede

62 otential implications for radiative forcing, residence times and other aerosol characteristics.

63 an time-integrated activity coefficients and residence times and, finally, organ-absorbed doses.

64 on from stream sediments requires subsurface residence times (and microbially mediated reduction rate

65 long a biome type persists at a given site (residence time) and how long it takes for the biome at t

66 1 exhibits higher tumor uptake, longer tumor residence time, and improved tumor-to-kidney dose ratio

67 mprovements in cellular potency, drug target residence time, and pharmacokinetic parameters.

68 Nutrient sources, sinks, residence times, and elemental ratios vary over broad sc

69 on of cellular potency, in vitro drug-target residence times, and in vivo PK properties, to identify

70 The residence times are estimated by combining a kinetic mod

71 docytic patches, we detected single-molecule residence times around 1 to 2 s, and similarly high turn

72 of the Fab' fragment had an influence on its residence time as well and the anti-IL-17A Fab' benefite

73 highly controlled polymerizations occur with residence times as low as 6 ms (TOF = 24 000 000 h(-1))

74 we are able to estimate yeast TBP-chromatin residence times as short as 1.3 minutes, demonstrating t

75 These couplings required residence times as short as 3 minutes to effect completi

76 broad range of angular displacements with no residence time at any given site.

77 However, vinculin residence time at FAs varied linearly with applied force

78 In contrast, paxillin residence time at FAs was independent of local applied f

79 Paxillin recruitment and residence time at FAs, however, were dependent on cytosk

80 t wildfires may decrease floodplain sediment residence time at high elevations.

81 substitutions of desloratadine increase the residence time at the H(1)R, conveying a longer duration

82 tadine (1) and desloratadine (2) have a long residence time at the histamine H(1) receptor (H(1)R).

83 ns, also exponentially decreased the motors' residence time at the microtubule end.

84 scFv-TM in both pulmonary targeting and lung residence time (AUC(inf) 141 +/- 3.2 vs 12.4 +/- 4.2 ID/

85 ound that this therapeutic had the best lung residence time (AUC(inf) 253 +/- 18 ID/g*hrs) of all TM

86 A new computational parameter, mean blood residence time (Blood(RT)), was computed for 100 coronar

87 ic transfer efficiency (TTE) and the biomass residence time (BRT) in the food web.

88 o-brain delivery by not only enhancing nasal residence time but also minimizing the mucociliary clear

89 We solve the mechanism of the target residence time by comparing functional off-rates in vitr

90 We propose that modulation of Rok membrane residence time by Crumbs' downstream effectors can recon

91 eases in the RPV apparent half-life and mean residence time compared to native drug formulation.

92 spacer) have decreased binding affinity and residence time compared to their methylene-linked struct

93 for systems influenced by transient or short-residence-time conditions and in some cases could possib

94 Patterns of camp residence times conformed well with the predictions of t

95 ure in high yields and within a few minutes' residence time, considerably enhancing the applicability

96 adsorbed water in locations and with partial residence times consistent with experimentally determine

97 ivity increases with soil fertility, whereas residence time decreases, and biomass responses are vari

98 2018 has warped the MJO life cycle, with its residence time decreasing over the Indian Ocean by 3-4 d

99 ffinity to their binding sites (e.g., longer residence times) delay entry to the power-law regimes.

100 In human cells, FACT depletion extends dCas9 residence times, delays genome editing, and alters the b

101 In particular, we introduce a water residence time dependence, which kinetically limits the

102 Residence time did not affect the carbon specific iron-b

103 The force dependence of the end residence time enabled us to estimate what force must ac

104 Longer residence times enhanced the purity of target feruloylat

105 influence of the various process conditions (residence time, enzyme concentration, substrate concentr

106 While the absolute residence times estimates can depend on imaging acquisit

107 ey primary producers in this relatively long residence-time estuary.

108 Live biomass and dead organic carbon residence times exhibit contrasting spatial features (r

109 pical forest biomass, productivity and woody residence time, focusing on mature forests.

110 deep-to-surface circulation (i.e., a longer residence time for Antarctic surface waters) prolonged i

111 x 10(9) g V/y inputs and outputs, and a mean residence time for dissolved V in seawater of about 130,

112 Insufficient residence time for efficient reduction of antimonate to

113 rates of fixed N input and loss and a longer residence time for oceanic fixed N-a "sluggish" ocean N

114 are able to derive the physical half-life or residence time for TATA-binding protein (TBP) across the

115 The residence time from formation of the trichloroacetyl com

116 ghly inefficient due to rapid clearance (low residence time) from ocular surface.

117 ere found in deeper, older groundwater (mean residence time >300 y).

118 ld, respectively) resulting in long receptor residence times (>400 min) for basimglurant and mavoglur

119 e, we find that extending the surface carbon residence time has the potential to efficiently enhance

120 yield desired regulatory phenotypes: low TF residence time, high specificity, and tunable cooperativ

121 grins, high tension increases beta3 integrin residence time in adhesive regions.

122 We provide a direct estimate of magma residence time in basaltic systems of the deep crust by

123 concentration and have long intra-cartilage residence time in both healthy and arthritic cartilage v

124 od C(max), AUC, extended half-life, and mean residence time in comparison to orally administered sild

125 Vinculin residence time in FAs correlated with applied force, sup

126 Tissue distribution and residence time in normal organs and tumors were analyzed

127 he whole body was calculated by entering the residence time in OLINDA/EXM 1.0 software to model the e

128 public understanding about carbon dioxide's residence time in the atmosphere.

129 ce the resulting peptide profile such as the residence time in the autosampler at 4 degrees C, stoppi

130 ll these drugs, which in general have a long residence time in the body, can stably be labeled with (

131 pHrodo-labeled virus particles' entry and residence time in the endocytic compartment were tracked

132 Both MAbs reduced H3N2 virus residence time in the endocytic pathway, suggesting fast

133 Moreover, we find evidence that a longer residence time in the ER-PM contact point is due to the

134 Post-MI leukocyte density, residence time in the infarcted area, and exit from the

135 7.2/3 heteromeric channels by prolonging the residence time in the open state.

136 Next, we evaluated silver residence time in the sinus cavity after intranasal deli

137 binding of the mismatch, which increases its residence time in the vicinity of the mismatch, coupled

138 h hotspots is made up for by enhanced tracer residence time in their vicinity due to diffusion toward

139 sting physical and chemical properties, mean residence times in soil, and responses to land use chang

140 ELMs with therapeutic functions and extended residence times in the gut.

141 investigation of low affinity molecules with residence times in the micro- to millisecond time regime

142 toring of embedded SWCNT sensors also allows residence times in the roots, stems and leaves to be est

143 m compared to 5ppm), and significantly lower residence times in the sinus cavity (AgNP concentrations

144 years), with reductions of 1 year of carbon residence times in vegetation (r(veg) ) and of 9 years i

145 on, chemotaxis may work to enhance bacterial residence times in zones of contamination, thereby impro

146 s fractured aquifers; however, the impact of residence time (inactivation/death) versus removal (pore

147 that as waterfowl occurrence probability or residence time increase at a given location, so too does

148 ad, Si : DIN increased slightly as reservoir residence time increased.

149 eochemical tracers combined with groundwater residence time indicators to investigate the sources of

150 Recently, it was shown that ligand residence time is a key factor determining steroidogenic

151 s of copper-binding capacity with increasing residence time is caused by intracolloidal interactions

152 As this relatively short residence time is just after ignition, this study is tar

153 for their overall productivity and that (v) residence time is the primary driver in the productivity

154 these candidate biomarkers have long tissue residence times, long-term feeding studies are needed fo

155 , remeglurant, and (RS)-remeglurant, and low residence times (<10 mins) for dipraglurant, F169521, F1

156 tain topographic and transcriptional (Pol II residence time) maps of canonical, H2A.Z, and monoubiqui

157 er, and suggest that biochar's environmental residence time may be underestimated when based on natur

158 The increased tracer residence time may explain the large vertical fluxes of

159 Much shorter residence times may not be feasible because oxidation ch

160 requiring nucleolytic rescue, and its short residence time minimizes RNAP inhibition.

161 ar fluid showed significant increase in mean residence time (MRT) and area under curve (AUC), with TM

162 ]levocetirizine radiolabel, we find that the residence time of 1 exceeds that of 2 more than 10-fold.

163 ighly transient and dynamic (with an average residence time of 1.5 sec).

164 >4-log NDMA removal in a single pass (liquid residence time of 11 to 22 s) through the PAC-REM and MW

165 cleared rapidly from the blood, with a mean residence time of 2.4 +/- 1.1 min/L.

166 inlet concentration of 404 ppm(v) and a gas residence time of 21 s.

167 , under similar operating conditions (liquid residence time of 22 s), achieved 92 to 97% removal with

168 s obtained in 73 % isolated yield in a total residence time of 27 minutes, corresponding to a through

169 t contribution of 1% in surface waters and a residence time of 30 days most closely match the ICR dat

170 of measles therapeutic, AS-136A, in a total residence time of 31.7 min (1.76 g h(-1) ).

171 The end-to-end process has a residence time of 4.7 min with a 15.8 g/h throughput at

172 mpounds I and II exhibited a prolonged serum residence time of 48 hours and concentration maximum (Cm

173 Within a total residence time of 9 min, the sodium salt of ciprofloxaci

174 The residence time of a drug on its target has been suggeste

175 evealed that GR increases the number and DNA residence time of a portion of chromatin-bound CREB1 mol

176 osylated GFP substantially reduces the Golgi residence time of a Tac chimera suggests that N-glycans

177 20kDa or 40kDa, had a moderate effect on the residence time of an anti-IL-17A Fab' fragment in the lu

178 PEGylation has been shown to increase the residence time of anti-interleukin (IL)-17A and anti-IL-

179 highly dynamic inside cells, with an average residence time of approximately 0.2 s.

180 crease the penetration (higher Cmax) and the residence time of bevacizumab into the brain (higher Cla

181 controlling not only the aquatic fluxes and residence time of carbon but also metal nutrients associ

182 ly 689+/-53 (14)C-yr increase in the average residence time of carbon in the deep ocean at the LGM.

183 first direct experimental observation of the residence time of Cd(2+) coordinated water in any system

184 strial biosphere and atmosphere and infers a residence time of CO2 of 1.9 +/- 0.3 years (upper limit)

185 ng extended loop extrusion by increasing the residence time of cohesin on chromatin.

186 particle scavenging and the relatively short residence time of deep water in the Basin.

187 cal weathering on timescales longer than the residence time of DSi (< approximately 100 Kyr).

188 Leveraging the long residence time of eIF5B on the ribosome recently identif

189 ow entry to elongation was defined by a long residence time of eukaryotic initiation factor 5B (eIF5B

190 streams prior to the flood to estimate mean residence time of floodplain sediment.

191 places firm constraints on the total crustal residence time of mantle-derived magmas and has importan

192 ecause this interval is far shorter than the residence time of marine sulfate, any change in the sulf

193 The subsequent residence time of model permeants in tissue after ultras

194 e specificity and prolonging intra-cartilage residence time of OA drugs.

195 Biomes have a median residence time of only 230-460 years.

196 on factors are believed to have a very short residence time of only a few seconds on their specific D

197 The findings provide strong support for the residence time of paused Pol II elongation complexes bei

198 e is known about the factors that affect the residence time of PEGylated antibody fragments in the lu

199 resistant mutants show reduced affinity and residence time of POA consistent with a model where resi

200 The residence time of protein substrates in the cavities of

201 one (BTL), likely a result of prolonging the residence time of reaction intermediates in the hydrophi

202 o 40 kDa was previously shown to prolong the residence time of rhDNase in the lungs of mice after pul

203 transfer of BTB was achieved within a short residence time of several minutes under optimized condit

204 r, fast clearance mechanisms result in short residence time of small molecule drugs in the lungs.

205 Summer Monsoon rainfall have controlled the residence time of soil carbon in the Ganges-Brahmaputra

206 n products produced, (2) control the average residence time of the active solutes, and (3) have the a

207 ute lung inflammation slightly shortened the residence time of the anti-IL-17A and anti-IL-13 Fab' fr

208 The residence time of the Cd(2+)-bound water molecule is ten

209 The chromatin residence time of the long bound fraction was up to 1 mi

210 ess under temperature conditions of a finite residence time of the molecule, the reactand diffusion c

211 A similar trend was observed in the residence time of the nearest water neighbors.

212 ewer degradation could occur during the mean residence time of the sewer network.

213 Here, we show that the estimated residence time of the short-residence molecules is essen

214 me settlement success (p > 0.05); and 4) the residence time of the sperm within the bank was not impo

215 sity can also be used for enhancing intra-NP residence time of therapeutic drugs.

216 %), resulting in marked enhancement of blood residence time of tPA from minutes to several days witho

217 nd Mn(II) oxidation are slow compared to the residence time of water in the pumping well; however, ad

218 ffects both the equilibrium constant and the residence time of water, while, surprisingly, the metal

219 ket motion coincides both with the estimated residence time of Zn-bound water/OH(-) in the pocket sho

220 Experiments were performed at hydraulic residence times of 14, 7, and 3.5 min and calcium to ure

221 However, the residence times of cardiolipin molecules with the ring w

222 iation rates are determined from interfacial residence times of individual DNA duplexes.

223 is discrepancy is notable because the longer residence times of lentic and terrestrial systems may en

224 pe signatures combined with mean groundwater residence times of more than 300 years for groundwater w

225 tion of carbonaceous materials increased the residence times of NDMA in the REMs by a factor of 3.8 t

226 The residence times of PFAS in the surface ocean, assuming t

227 quantify the influence of chemotaxis on the residence times of pollutant-degrading bacteria within h

228 stimated, calculated to be 8.3 min (combined residence times of root and stem) and 1.9 min mm(-1) lea

229 oving SOC by depth, indicated by much longer residence times of SOC in deeper layers.

230 Long residence times of soil organic matter have been attribu

231 srupt transcription initiation) and variable residence times of TBP complexes at a promoter.

232 ays through these residues based on the mean residence times of the transferring charge along these h

233 ysis of these data suggests that drug-target residence time (off-rate) may be an important attribute

234 es consideration of factors influencing PRC2 residence time on chromatin and PRC2 catalytic activity

235 eir simultaneous removal increases cohesin's residence time on chromatin and slows down DNA replicati

236 Increasing Scc1 residence time on chromosomes by Wapl depletion leads to

237 -containing diphenyl ether with an increased residence time on InhA due to transition-state destabili

238 dition, we identify a novel inhibitor with a residence time on InhA of 220 min, which is 3.5-fold lon

239 Ask1 component of the Dam1c to increase its residence time on microtubules and enhance kinetochore-m

240 additional protein factors contribute to EB3 residence time on MTs in cells, likely affecting MT dyna

241 arger pool of newcomer SGs that undergoes no residence time on plasma membrane before fusion and, to

242 erences were found in migration distance, or residence time on summer ranges.

243 activity by tuning the transcription factor residence time on target sites.Both transcription bindin

244 and SpoIVA, wherein SpoVM displays a longer residence time on the forespore surface, which favors re

245 rmine whether 15a, an antagonist with a long residence time on the human CCR2, is effective in inhibi

246 the identification of molecules with a long residence time on the target protein, high permeability,

247 The modulation of p53 residence times on chromatin requires C-terminal acetyla

248 the reported short transcription factor (TF) residence times on the DNA with the high specificity of

249 The capability to measure residence time over single tidal cycles in estuaries wil

250 D-based protocol, which showed potential for residence time prediction in drug discovery.

251 ence of HABs in Lake Okeechobee, short water residence times produced by discharges into the St.

252 N2O emissions; only specific, intermediate, residence times (reaction rates) will both produce and r

253 ty, faster tree turnover, and shorter carbon residence time, reduces the capacity of forest ecosystem

254 RF molecules segregated into three chromatin residence time regimes, short, intermediate, and long bi

255 distal to a stenosis, increasing mean blood residence time relative to uninhibited flow.

256 input variables, such as chamber volumetric residence time, relative humidity, initial concentration

257 We found hA3R antagonists with very short residence time (RT) at the receptor (2.2 min for 5) and

258 d affinity, kinetic parameters kon, koff and residence time (RT) were determined.

259 ent probe endowed with improved affinity and residence time (RT).

260 ey confinement is a significant predictor of residence time, sediment flux, and floodplains disturbed

261 erosol and gas-phase glyoxal with only 1 min residence times, significant aerosol growth is observed.

262 Residence time significantly increased with proximity to

263 system that primer-primase complexes have a residence time similar to the timescale of Okazaki fragm

264 d in sequencing batch reactors (8 day solids residence time, SRT) subjected to identical diel light c

265 have been introduced to optimize absorption, residence time, stability, route of delivery and frequen

266 and acetylation of APE1, which enhances its residence time, stabilizes G4 structures in cells.

267 nity of COF films is observed only at longer residence times, suggesting that oligomeric and polymeri

268 es were significantly longer compared to end residence times, suggesting the presence of a distinct f

269 muM, and an atypical low dissociation rate (residence time tau = 205 min).

270 cal rigidity, better bio-adhesion and longer residence time than Poloxamer hydrogels currently being

271 We find that multiple starting poses yield residence times that roughly agree with the experimental

272 bution of folding times, which matches these residence times, thereby suggesting that both bullet-sha

273 ystems; (ii) the high Cl(-) content and long residence time (thousands of years) promote the leaching

274 as a strategy to greatly increase the target residence time (TRT) of inhibitors.

275 has implications for the design of new long-residence-time TSPO ligands.

276 er processes under all tested conditions and residence times up to 12 h.

277 e diaryliodonium salts on a gram scale, with residence times varying from 2 to 60 s (44 examples).

278 mechanism of the modulation of Rok membrane residence time via affecting the k(off) that may be wide

279 The tumor residence time was 15.6 h (13.4-17.7) for (177)Lu-OPS201

280 Mean (+/- SD) projected peritoneal residence time was 22.4 +/- 7.9 hours.

281 ligand, was 0.75 x 10(-4) when the reservoir residence time was 5 h but 0.34 x 10(-4) when it was 25

282 correlation between inhibitor reactivity and residence time was demonstrated through quantum mechanic

283 thermal shift assay (CETSA), and drug-target residence time was determined via SPR.

284 The average Spt4/5 residence time was of similar magnitude to the time requ

285 In contrast, a long receptor residence time was responsible for the prolonged effects

286 By quantitatively measuring their Golgi residence times, we found that the observed Golgi locali

287 Parallel TDs that vary in temperature and residence time were used with an evaporation-kinetics mo

288 lly, scaled to a sex-specific reference, and residence times were calculated for input into OLINDA/EX

289 Time-activity curves were generated, and the residence times were calculated.

290 Residence times were determined from time-activity curve

291 Subjects' patch residence times were longer at safe than at risky statio

292 tion that predicts longer than optimal patch residence times when food is plentiful.

293 We found a dramatic shift in litterfall residence times, where cocoa leaves decomposed more slow

294 Lipids increase gastric residence time, which could increase iron absorption, pa

295 oscillatory flow strategy enables a flexible residence time while preserving the mixing and heat tran

296 ecule to their antibody pairs prolongs their residence time, while the nontarget small-molecule disso

297 s, we could significantly prolong the target residence time with one example to 3663 s, along with an

298 b vs. scFv), but marked differences in organ residence time, with antibodies demonstrating an order o

299 within the lungs had a major impact on their residence time, with the deeper the delivery, the more p

300 rs, but not their diffusion behaviors or SMT-residence times within chromatin, distinguish functional