ライフサイエンスコーパス: residual activity

1 ompared to wild-type TPH ( approximately 5 % residual activity).

2 produced an effect on kinase activity (<10% residual activity).

3 o alanine gave mutants with approximately 2% residual activity.

4 s of function and mutations that leave a low residual activity.

5 ith late-onset phenotypes showed up to 2.15% residual activity.

6 glutathione S-transferase to a limit of 60% residual activity.

7 nase-deficient c-Abl mutant still retained a residual activity.

8 a missense mutation and is likely to retain residual activity.

9 ctions (AMRs) occurred without detectable C5 residual activity.

10 ter 30minat 75 degrees C it showed about 10% residual activity.

11 oter reporter constructs tested exerted only residual activity.

12 meric capping protein (CP) accounts for this residual activity.

13 ne months, suggesting potential for extended residual activity.

14 , lactate dehydrogenase levels, and ADAMTS13 residual activity.

15 on, often compromise structural integrity or residual activity.

16 utant CodY proteins with different levels of residual activity.

17 ed with free enzyme which showed only 30% of residual activity.

18 three months with retention of more than 80% residual activity.

19 he cryb mutation, implying that CRYb retains residual activity.

20 he heme is conserved, which accounts for the residual activity.

21 ent inactivation of GST pi to a limit of 25% residual activity.

22 to inactivity rather than to differences in residual activity.

23 ty of the complete enzyme but possessed its "residual" activity.

24 ve dose was calculated from administered and residual activities.

25 ately 50% first step activity, displays only residual activity (0.2%) in the production of squalene f

26 Red blood cell glucose uptake residual activity, a surrogate of haploinsufficiency, co

27 nd reusability with retention of 72% and 60% residual activity after 10 uses for the enzyme immobilis

28 at room temperature for several months (92% residual activity after 260 days storage) and demonstrat

29 The immobilized enzyme exhibited around 82% residual activity after being stored for 120 days.

30 screened for improved stability by measuring residual activity after incubation under conditions mimi

31 The nanocomposite retained 60 % of its residual activity after three months of storage.

32 tability changes only weakly correlated with residual activity against UDP-galactose.

33 ine to glutamine mutant displays the highest residual activity and a pH profile similar to that of th

34 SMA-11 is promising, although limited by low residual activity and artificial signals.

35 selenocysteine insertion domain resulted in residual activity and caused reduced selenoprotein trans

36 plicing, giving rise to isoforms that retain residual activity and contribute to therapeutic resistan

37 The low residual activity and high chemical stability of Nmoc-Gl

38 that Nmoc-Glu, indeed, has exceptionally low residual activity and high chemical stability.

39 E536Q and L175F mice had low levels of residual activity and milder phenotypes.

40 s must be cleaved in several pieces to avoid residual activity and minimize the risk of reintegration

41 vement in reverse sulfurylase activity (<10% residual activity) and complete restoration of forward s

42 owever, the mutated enzymes still maintained residual activity, and both mutant enzymes still bound t

43 me mutations result in heterodimers with the residual activity anticipated from individual constituen

44 ned by the inter-FVIIIa subunit affinity and residual activity approaches a value consistent with thi

45 O), and this inhibits catalysis; and (d) the residual activity arises from either the (CO)nECO state

46 Cr3+(n1)-PEPCK retains 15% residual activity as compared to unmodified PEPCK and de

47 purification steps, we demonstrate that the residual activity associated with the purified covalent

48 CAP1 activation was also altered with marked residual activity at high Ca(2+), the effect increasing:

49 ese data also provide evidence for localized residual activity at the cortical level.

50 utaneous radioligand administration, average residual activity at the injection site was less than 17

51 llow an a priori prediction of heterodimeric residual activity based solely on the in vitro activity

52 ntials by approximately 70% (P < 0.01), with residual activity being blocked by the Na(V)1.3 inhibito

53 D, and 7 were patients with profound BD with residual activity below 10%.

54 lity decreasing below 50% within 2 months in residual activity bioassays.

55 ion in GM-CSF-stimulated glucose uptake with residual activity blocked by wortmannin.

56 The CFTR-W1282X protein has residual activity but is expressed at a very low level d

57 he R133P-beta mutant E1 exhibits significant residual activity but is markedly less stable than the w

58 a stable enzyme-adenylate complex, although residual activity can be detected at high ATP concentrat

59 Residual activity can be explained because each of these

60 n the tga2 tga5 tga6 triple mutant, and this residual activity cannot be suppressed by SA.

61 eta gene with +33 mutation showed 25% to 35% residual activity compared with normal.

62 ng aspartate 283 to alanine (D283A) left 10% residual activity, contrary to a previous report, but co

63 In two cases, the H6Q and D24N proteins, the residual activities could be markedly stimulated by addi

64 acid-sphingomyelinase deficiency (i.e., <2% residual activity) demonstrate abnormal permeability bar

65 This residual activity depends on the C-box domain of Cdh1, b

66 This residual activity depends significantly on the linker re

67 , which yield a protein that may retain some residual activity, each NFRCD mutation is likely to give

68 Enzymatic parameters (K(M) and V(max)), residual activity, effect of bentonite and electrophores

69 the ratio of TEE to REE (TEE:REE) (PAL) and residual activity energy expenditure (RAEE).

70 he immobilized enzymes retained up to 75% of residual activity even after eight consecutive cycles of

71 ions affords a modified enzyme with only 14% residual activity even though NFM and NEM target the sam

72 d enzyme exhibited a retention of nearly 80% residual activity following 12 successive reuses.

73 Residual activities for complexes I, II, and IV in muscl

74 unction mutants; furthermore, the measurable residual activities for T289C, Y293C, and A301C (<or=20%

75 Kinetic and NMR assays detect significant residual activity for all of the mutants.

76 strate to that of wild type, but it only has residual activity for G:U and no detectable activity for

77 ently immobilized protein compared to 20% of residual activity for the adsorbed protein after 25 d st

78 ckout system for Val339Gly and Gly19Glu, and residual activity for Trp505* due to read-through.

79 h were adjusted by subtracting the estimated residual activity from the first (18)F-FDG injection.

80 fore the second injection was performed, and residual activity from this additional delayed scan was

81 for the BH4 responsiveness; the mutants show residual activity (>30% of WT) and display various kinet

82 This residual activity, however, was diminished by combining

83 s not known whether cytoplasmic APOBEC3G has residual activity in activated T cells, even though viri

84 oid lambdacyhalothrin demonstrated prolonged residual activity in bioassay tests but failed to contro

85 ial (CRIM SA) in the baculovirus system, the residual activity in both patients was primarily from th

86 Residual activity in competitive attractor networks with

87 in adult HSCs is catalytically inactive, its residual activity in Dnmt3a-null HSCs can drive some dif

88 onger activation by light as well as a lower residual activity in the dark.

89 DH dependent and inhibited by triclosan; the residual activity in the fabI mutant was also NADH depen

90 The residual activity in the mutant L-CPTIs was sensitive to

91 aphy for detection of distant metastases and residual activity in the neck following thyroidectomy.

92 tic depression may actually be driven by the residual activity in the visually deprived retina.

93 of RDH12, T49M and I51N, exhibit significant residual activity in vitro, but are unable to control re

94 e ready-to-use formulations with significant residual activity in water can be developed.

95 stability and demonstrated up to six months residual activity in water.

96 s and in prothrombinase assays measuring FVa residual activity, in agreement with studies of purified

97 The PPO and POD's residual activity increased after HPH; PG was at the sam

98 and pre-steady-state kinetic analyses of the residual activities indicated that the rate-limiting ste

99 ivates heparinase I while a H203D mutant has residual activity, indicating a role of this residue in

100 The residual activity is attributed either to mistranslation

101 n partial function, and we deduce that their residual activity is dependent on the level of avrRpm1 s

102 nalysis of candidate genes revealed that the residual activity is due to alkyl hydroperoxide reductas

103 The residual activity is not coupled to the proton pump, and

104 y of LC/A by approximately 600-fold, and the residual activity is not inhibited by ArgHX.

105 The basis for the residual activity is probably as a result of expression

106 Surprisingly, we found that this residual activity is sufficient for wild-type levels of

107 Residual activity likely results from the synthesis of a

108 Residual activity may involve CO from the solvent bindin

109 Some of this residual activity might result from a neighboring argini

110 Significant residual activity not directly correlated with behavior

111 importance of these phosphates explains the residual activity observed for mutants that lack key res

112 (ii) mTLL-1 is an in vivo pCP that provides residual activity observed in Bmp1(-/-) embryos.

113 st whether this domain might account for the residual activity observed in ExoT GAP mutants.

114 Instead, the diminished sensitivity of the residual activities of E305Q and D504N mutants, but not

115 eral bound products that are formed owing to residual activities of hydrolysis and transglycosylation

116 Switching plasma input gas to nitrogen, the residual activities of lipase and lipoxygenase after the

117 rs such as the function of mutated genes and residual activities of mutant alleles.

118 e biosensor configuration, the enzyme gave a residual activity of 0.18% of the amount originally appl

119 choroid plexus was essentially ablated (i.e. residual activity of 10.9 and 3.9% at 5 and 30 min, resp

120 ong-term stability experiments show a better residual activity of 40% for the covalently immobilized

121 s include strategies aimed at increasing the residual activity of a missing enzyme (enzyme replacemen

122 alternative splicing of exon 2 modulates the residual activity of AMPD1 in individuals with this muta

123 Mn(II) supports residual activity of both the native and fluorinated enz

124 ization capacity, raising the possibility of residual activity of channels formed by TRPV6(D541A) pro

125 Residual activity of D195A is very low, V87A is not expr

126 susceptibility produced by mutations and the residual activity of drugs against resistant viruses.

127 e camptothetin analog, Topotecan, can reduce residual activity of HIV in an experimental model of HIV

128 types of the independent HvAST mutants imply residual activity of HvCMF7 in the original albostrians

129 Residual activity of K165M is insensitive to pyridoxal p

130 Using argon as plasma gas, the residual activity of lipase and lipoxygenase decreased t

131 great interest, as Cosnier et al. reported a residual activity of only 0.33% of the amount initially

132 tely 9 half-lives of (89)Zr and with a total residual activity of only 20-40 kBq in the animal, the i

133 from harvesting to steaming 2 h leading to a residual activity of polyphenol oxidase of 1.31% and a c

134 he total available protein to counteract any residual activity of prolyl hydroxylases.

135 Despite PI3K inhibition and AKT suppression, residual activity of protein S6, a core marker of prolif

136 The study evaluated the efficacy and residual activity of SumiLarv 2MR, SumiLarv 0.5G, and Ab

137 Further, the residual activity of T229E-p70s6k was not affected by ra

138 a highly conserved active site residue, the residual activity of tBPA-labeled 2B4 observed in previo

139 me pathogenic variant had varying degrees of residual activity of the affected complex, alluding to t

140 We found that the residual activity of the alpha H44A luciferase was marke

141 the plasma is usually measured based on the residual activity of the C1s protease not involved in th

142 the predicted effect of the mutations on the residual activity of the DTDST protein.

143 The residual activity of the enzyme after GSNO treatment was

144 The initial rate vi represents the residual activity of the enzyme before inhibitor dissoci

145 A tailor-made ink was studied, and the residual activity of the enzyme was 85% after additives

146 entified receptor responsive to estrogen, or residual activity of the ERalpha splice variant reported

147 Residual activity of the gossypol-modified PLA2 from sev

148 vations and highlights the importance of the residual activity of the insecticide for this technique.

149 These results suggest that shutting down the residual activity of the limbic-arousal system might be

150 l, there was a close correlation between the residual activity of the mutant enzymes and the clinical

151 ntation experiments in yeast showed that the residual activity of the mutant proteins correlates with

152 ato carboxypeptidase inhibitor inhibited the residual activity of the mutants.

153 nd HMGCS1, which creates a dependence on the residual activity of the pathway in ARID1A-inactivated c

154 attenuated but not absent in mice with only residual activity of the phosphatase Src homology 2 doma

155 y decreases its activity as shown by the low residual activity of the recombinant phosphomimetic muta

156 Thus, both patients depend upon residual activity of the S209L mutant to support low lev

157 otransduction cascade during the light step, residual activity of the transduction cascade after the

158 0-fold in kcat with no change in Km, and the residual activity of the unresolvable P1V/M1P2V mixture

159 still degrade longer peptide substrates via residual activity of their Z subunits.

160 We found that the residual activity of these GMMA is largely due to non-li

161 ies in the patient with IH may be due to the residual activity of this mutant in activating the Dlx2

162 ntents of different isoflavone forms and the residual activity of trypsin inhibitors.

163 to myosin and the irradiation eliminates the residual activity of unbound inhibitor molecules, azidob

164 We determined that, in general, the residual activity of ZMPSTE24 patient alleles correlates

165 roinjection of dead PKAc reflects either low residual activity or binding to regulatory subunits with

166 crease in storage stability, retained 92% of residual activity over a period of 8 months.

167 patial lowpass and highpass filters, and the residual activity patterns then analyzed by linear class

168 for most of the FFA efflux in E. coli, with residual activity provided by other resistance-nodulatio

169 ne of the two heterozygous mutations has any residual activity remaining.

170 taryl-CoA dehydrogenase exhibit 7% and 0.04% residual activity, respectively, with human electron-tra

171 Gln mutants exhibited less than 0.5 and 0.1% residual activity, respectively.

172 ressing wild-type or mutant COX10 (retaining residual activity) restored complex I to normal levels.

173 f LKB1 in cellular systems revealed that the residual activity retained in a reported kinase-dead for

174 ly samples characterised by a pectinesterase residual activity showed a softening also after one mont

175 negatively charged substitution mutants with residual activity suggests that the introduction of addi

176 th iTTP showed that GC1126A exhibited higher residual activity than rh WT-ADAMTS13, particularly in p

177 uster have a significantly greater impact on residual activity than would be predicted.

178 Single and double mutants show 20-60% residual activities that are not stimulated by the PDC c

179 dimers between two mutant CobT proteins with residual activity that is so low that the resulting CobT

180 h of isolating its minimal fragment that has residual activity (the "minichaperone" core) and then id

181 nism 1B form in which mutant proteins retain residual activity, the severity of albinism depends on t

182 somal elements were recovered and probed for residual activity through their transfection in uninfect

183 cyclin/CDK complexes could leave sufficient residual activity to promote S phase, or S phase-promoti

184 to the formation of modified enzyme with 92% residual activity toward 1-chloro-2,4-dinitrobenzene and

185 CO2 revealed similar inhibitory behavior and residual activity under saturating [CO].

186 One patient with residual activity underwent immediate biopsy that reveal

187 offers good reusability as it retained ~50% residual activity up to 21 reuses and exhibited higher r

188 issense mutations were expressed to quantify residual activity using a new assay.

189 However, a low level of residual activity was detected, suggesting that a second

190 inding of the two PNPO dimers, and with high residual activity was found in Groups (ii) and (iii).

191 When FVa residual activity was measured after long exposure to AP

192 Presence of 1 mutation with residual activity was necessary but not sufficient for a

193 However, 0.2-0.4% residual activity was observed for the H145A mutant of h

194 The highest residual activity was observed with the His(34) position

195 with Ala reduced activity by 99.95%, and the residual activity was relatively unaffected by diethyl p

196 However, some residual activity was seen, presumably as a result of ra

197 As a likely explanation of this residual activity, we showed that CTbeta2, a form of CT

198 nitrocatechol sulfate (pNCS), detectable ASA residual activity were observed in primary and SV40t fib

199 Significant differences in prolonged (residual) activities were also observed for these modifi

200 ss cobalamin, whereas mut- mutations exhibit residual activity when exposed to excess cobalamin.

201 and R332H polypeptides revealed significant residual activity, whereas reverse transcription-PCR and

202 e Glu-243 to Asp mutant had approximately 2% residual activity, whereas the Glu-243 to Ala or Gln mut

203 , present mostly as monomers, K12A displayed residual activity, which could be attributed to the cons

204 both PPi hydrolysis and H+ translocation and residual activities with decreased DCCD sensitivity.

205 . crassa ND1 intron, but retains substantial residual activity with the mt LSU intron, and conversely

206 g the mt LSU intron, but retains substantial residual activity with the ND1 intron.

207 Correlation of residual activity with the number of histidines modified

208 t = 19.9 +/- 1.1 min-1, while R166A has only residual activity, with a kcat = 0.012 +/- 0.001 min-1 a