ライフサイエンスコーパス: residue

1 , as it already contained the optimal Env375 residue.

2 omerization and its dependence on the His136 residue.

3 egions rich in proline and other hydrophobic residues.

4 f which were found to contain Sudan I and IV residues.

5 can efficiently myristoylate specific lysine residues.

6 reaction pathways of (1)O(2) with tryptophan residues.

7 rtially conserved (W) and non-conserved (N9) residues.

8 hyde adduct formation on lysine or histidine residues.

9 bound AcCYP51 failed to refold 74 N-terminal residues.

10 in interactions through glycosylation of key residues.

11 cyl adducts with lysine and several tyrosine residues.

12 ggesting functional roles for these specific residues.

13 alable method to predict ligand-binding site residues.

14 k Diffraction Precision index, or unresolved residues.

15 sible for the generation of large amounts of residues.

16 O-GlcNAc modified at S852, T1009, and S1147 residues.

17 rotein product of which lacks key functional residues.

18 using sequence variants often affect binding residues.

19 ng either sialic acid, sulfate, or phosphate residues.

20 rnal ring of hydrophobic side chains of L279 residues.

21 conformation of backbone and key side-chain residues.

22 ved separate NMR structures of the IQ motif (residues 1,646-1,664) bound to alpha-actinin-1 and to ap

23 We find that residues 11-42 and 69-102 adopt beta-sheet conformation

24 ctural motifs, including fluorine-containing residues, 12,13-difluorocyclopropyl moieties, mono- and

25 ), an N-terminal truncation up to amino acid residue 209 altered the conformation of the S1-S2 linker

26 This structure is formed by six residues ((243)VLRFMT(248)) that are essential for respo

27 h IFT dynein subunit D1bLIC, and deletion of residues 261-275 reduced this interaction.

28 urther mapped to discontinuous regions among residues 286-306 and 339-378 that, when introduced in 88

29 Deletion of residues 342-356 of Chlamydomonas IFT54 resulted in dimi

30 we identify a 7-residue sequence, named P1 (residues 36-42), that controls alphaSyn aggregation.

31 revealed that PA amino acid substitutions at residue 38 (I38T/F/M) reduced BXM potency and caused vir

32 mutations caused substitution or deletion of residues 527, 528, and 530, which are crucial for S1P cl

33 modification occurs predominantly on serine residues(6-8) and requires HPF1, an accessory factor tha

34 SFMBT1 hydroxylation on Proline residue 651 by EglN1 mediated its ubiquitination and deg

35 MKIIalpha also directly binds Shank3 between residues 829 and 1130.

36 on-activated form of RAG1 with methionine at residue 848 and cryo-electron microscopy, we determined

37 the type 1 coordination observed in OvPrP at residues A136, R154, and R171, the metal is coordinated

38 Using differences in these residues across species, we developed a susceptibility s

39 leaves behind around 20 t ha(-1) of biomass residue after harvest and processing.

40 The residues after extraction were characterized and constit

41 Mass Spectrometry) analysis of the obtained residues allowed for quantification of the metal evapora

42 ns and conformational motions of interfacial residues along the PCET pathway.

43 Mutation of the acidic residue also abolishes auxin transport activity by ABCB1

44 Absence of a conserved basic residue and presence of acidic residues in the vestibule

45 ter bond formed between a thermolysin serine residue and the A2ML1 thiol ester.

46 lation of the four activation-loop threonine residues and binding of ATP-Mg(2+).

47 recPrP, where Cu(II) is coordinated by three residues and by one water molecule, making the non-OR re

48 terative algorithm to minimize the number of residues and locally restrict the artifacts caused by fi

49 he idea that oxidation of conserved cysteine residues and partial unfolding of its structure convert

50 he potency enhancing effects of the fluorine residues and the aziridinyl moiety within the structure

51 eractions between the side chains of the Nte residues and the FimA core and not by the antiparallel o

52 ostatic interactions between a pair of polar residues and the nitrogenous bases of an RNA target.

53 ers urgently need scientific evidence on GBH residues and their possible effects on ecosystems.

54 cterized and named ToPI1, with 33 amino acid residues and three disulfide bonds.

55 rane domains via a patch of basic C-terminal residues, and this membrane sequestration is disrupted i

56 curing efficient methylation of two 16S rRNA residues, and ultimately serves to coordinate subunit jo

57 gh protonation of CpxA periplasmic histidine residues, and upregulates the fabA and fabB genes, leadi

58 lective radical chemistry to target aromatic residues applying C-H (18)F-trifluoromethylation.

59 we propose that those C-terminal amino acid residues are a potentially targetable motif of TIMP-1 on

60 These residues are important for H(+) transport and voltage-de

61 When these amino acid residues are individually mutated, the necrosis-inducing

62 cells expressing Msh3 in which these lysine residues are mutated to arginine, the inhibitory effect

63 Natural products containing Dha and/or Dhb residues are often found to display diverse biological a

64 ncluding methylation of adenine and cytidine residues, are now recognized as key regulators of both c

65 an exposed beta-hairpin loop composed of six residues (Arg-Phe-Phe-Asn-Ala-Phe) that is imperative fo

66 Among these residues, Arg-277 appeared to be particularly important

67 Two predicted zinc-binding residues, Asp87 and His88, are required for MBLAC2 hydro

68 ce pH gating properties, as well as a single residue, aspartate 348, that determines both cation sele

69 ven protein result in an output defining the residues assigned to the bulk water phase, lipid interfa

70 Here, we focused on the amino acid residue at position 8 (P8) of the proteolytic cleavage s

71 al analysis demonstrates that the methionine residue at this position has a unique combination of len

72 sidues, including those in clusters of polar residues at both the N and C termini, and deletion of up

73 peptides bearing 3,5-dihydroxyphenylglycine residues at position 3 in their structures.

74 We show that variations in hydrophobic residues at the active site of class D SBLs (i.e. Trp(10

75 ime scales involving a repacking of aromatic residues at the interface with CI.

76 te the critical role of consecutive aromatic residues at the tip of the LBL for binding of HC/DC to l

77 Zta may be determined by the specific lysine residue being modified.

78 Mutants affecting residues belonging to the identified acceptor subsites s

79 Mutation of VPS28 helical interface residues blocks filament formation in vitro and autophag

80 G's hypochromism was larger for flanking G/C residues but its fluorescence quantum yield (QY) and lif

81 while significantly reducing the amounts of residue by 64%.

82 jB, are methylated at surface-exposed lysine residues by FliB.

83 -residue deletion at the N-terminus and a 16-residue C-terminal extension containing a histidine tag.

84 molecular and isotopic compositions of such residues can be used to reconstruct past resource use, a

85 experiments show that both acidic and basic residues can catalyze the reaction.

86 gy to Predict binding sites (GRaSP), a novel residue centric and scalable method to predict ligand-bi

87 CA) is a statistical framework that captures residue coevolution within proteins.

88 ambdaD)) to investigate the buried ionizable residues comprehensively and to elucidate their effect o

89 Hydrogen bonding interactions of Glu200 with residues conserved across the Dio family anchor the loop

90 ence reconstruction can efficiently identify residues contributing to allosteric signal propagation i

91 , and R171, the metal is coordinated by four residues; conversely, the type 2 coordination is present

92 Hence, RDV residues could be embedded in copies of the first RNA st

93 ing between three and fifteen monosaccharide residues covalently linked through glycosidic bonds.

94 tagenesis of both cofilin and actin revealed residues critical for sustaining or abrogating the light

95 a systematic approach to identify amino acid residues crucial for the expression and stability of FXI

96 ses, we show that the conserved nucleophilic residue Cys-122 is S-sulfenylated after substrate reduct

97 ved cysteine, Cys-66, or by the nonconserved residue Cys-127.

98 conformational changes of its two catalytic residues Cys282 and Glu248.

99 contrast, mutation of the Arg220 and Thr237 residues decreases the acylation rate and, paradoxically

100 C(H)2s has a 7-residue deletion at the N-terminus and a 16-residue C-te

101 mates, and we find that the same active-site residues discriminate between initiase and elongase glyc

102 neural network that learns to predict inter-residue distances and orientations from antibody heavy a

103 ons between the posttranslationally modified residues do not exert a major influence on the static st

104 This revealed a decline in the number of residues driving amyloid formation upon deleting at leas

105 cleavage after asparagine and aspartic acid residues during in-solution digestions of proteomes extr

106 tion and of finasteride inhibition involving residues E57 and Y91.

107 Similarly, replacing corresponding rTRPV1 residue E570 with lysine or glutamine retained capsaicin

108 ativity as the cumulative result of pairwise residue effects.

109 The medium formulated with 94% grape residue enabled the highest values of yield, biological

110 this report, we show that SHP2-targeted pTyr residues exist in a specific amino acid context that all

111 phosphorylation of the newly introduced Thr residue explains the functional change.

112 sing a Cys-reactive label that masks epitope residues, followed by infection of the labeled mutant vi

113 mes, we demonstrated that Y138 is a critical residue for Brd4 association and that inability to compl

114 tagenesis identifies serine 67 as a critical residue for MEIOB.

115 The use of terminal residues for labeling provides a universally applicable

116 indings define potential ACE2 and SARS-CoV-2 residues for therapeutic targeting and identification of

117 monstrate the importance of key coordinating residues for transporter activity, and provide a structu

118 The first comprises mutations at a nonanchor residue, for which we find that the predicted absolute b

119 e cytosolic domain and chelated by conserved residues from CTD and the His-Cys-His (HCH) motif from t

120 and 0.1% acetic acid) for removing carbaryl residues from cucumber and chili.

121 Removal of ubiquitin acceptor residues from the somatostatin receptor 3 (SSTR3) and fr

122 mutagenesis allowed us to identify 4 of 413 residues from TrpB that are crucial for its allosteric a

123 tighter interaction with the GluN1 M3 helix residues G638 and I642.

124 we characterized the function of the histone residues H4-S47 and H4-T30 in response to osmotic and he

125 termini, and deletion of up to 11 C-terminal residues had little impact on the agonist-induced respon

126 axin (79-207) in which the N-terminal lysine residue has been lost.

127 ween CBT derivatives and N-terminal cysteine residues has been established as a biocompatible reactio

128 ubstrate is accommodated and how active site residues have changed to recognize N-citrylornithine.

129 pid binding groove and clusters of conserved residues highlight potential functional sites.

130 R-H3 loops into the NA active site, engaging residues highly conserved among IBV NAs.

131 dine moiety and the latter with an NCO-alkyl residue (imide or carbamate).

132 Mutations of these invariant residues impair B3GNT2 activity in cell assays.

133 Here, we show that a single amino acid residue in CD28 drove T cell exhaustion and hindered the

134 study, we identified an aromatic hydrophobic residue in foot-and-mouth disease virus (FMDV) leader pr

135 s of the so-called bridging glutamate (E205) residue in intersubunit electron transfer.

136 that phosphorylation of a specific tyrosine residue in STING by the epidermal growth factor receptor

137 s, we hypothesized that Asn-169, a conserved residue in the AAG active-site pocket, contributes to di

138 We find that the arginine residue in the FLVR motif does not directly contact pTyr

139 lytic triad and unconventionally uses an Arg residue in the formation of an oxyanion hole.

140 We pinpointed Met-1669 as the residue in the GBA motif of DAPLE that diverges from tha

141 ated class-membership probabilities for each residue in the protein.

142 agine 285, which is replaced by an aspartate residue in type P(O) SadP, was required for binding to G

143 this issue, we exchanged selected amino acid residues in a highly conserved stretch within the regula

144 No assumption is needed on the number of residues in close proximity in space, in contrast to pre

145 mation kinetics, and presence of stabilizing residues in close proximity to the glycation sites.

146 We also noted a decrease in glycated lysine residues in collagen, indicating that the imine formed b

147 ctrometry (HPLC-QTOF-MS) was used to analyze residues in fish.

148 ctional assays to identify the actin-binding residues in FL villin that regulate its filament-bundlin

149 and C-Lip regions that are separated by 500-residues in humans.

150 1 ligase inhibitor or by mutating two lysine residues in intracellular loop three causes Smo to aberr

151 There are three, six, and six acidic residues in macrolittin70, pHD15, and MelP5_Delta6, resp

152 e, with analogues lacking key pharmacophoric residues in one dimer arm retaining high antagonist affi

153 rylation of the Igf1R on activating tyrosine residues in podocytes.

154 ins both in vivo and in vitro confirmed that residues in sequence motifs conserved across bacterial a

155 hich one or two of four highly conserved Trp residues in the binding tunnel had been replaced with Al

156 In contrast, we found two residues in the C-terminal domain, tyrosine 351 and glut

157 agenesis analyses helped us zoom in on three residues in the CT, namely Glu-719, Glu-721, and Leu-725

158 ious studies have implicated conserved basic residues in the cytosolic portions of beta- and gamma-EN

159 ify an unstructured loop of approximately 20 residues in the ExoU amino acid sequence.

160 eta-hairpin, the cyclophilin A-binding loop, residues in the hexamer central pore, and the NTD-CTD li

161 controlled by conformational variability of residues in the linker region and of dimer and trimer in

162 n between tau and LRP1 is mediated by lysine residues in the microtubule-binding repeat region of tau

163 Overall, mutations to residues in the middle and lower pore were more likely t

164 t-voltage curve, and substituting one or two residues in the selectivity filter drastically increased

165 nserved basic residue and presence of acidic residues in the vestibule regions, conserved only in Yfd

166 ne-315/316 (K315/K316) and lysine-510 (K510) residues in two distinct domains.

167 Key residues in VAMP4 that regulate its retrieval as well as

168 K1delta/epsilon with up to 38 phosphorylated residues in vitro and in vivo.

169 Three categories of agricultural biomass residues, including shell, fibre and soft peel, were inc

170 Ala substitutions for most alphaM4 residues, including those in clusters of polar residues

171 bserved at disulfide bonds but not at acidic residues, increasing and then apparently reversing, a pe

172 rthermore, neutralization of other H4c basic residues inhibited slc13 transport function, thus mimick

173 and consistent with long-thought residue-to-residue interactions between actin and tropomyosin.

174 small ubiquitin-like protein NEDD8 to lysine residues, interrupts degradation of DNMT3A1.

175 Introduction of these residues into Drosophila TRPA1 confers anesthetic inhibi

176 Incorporating these BMP15 residues into latent GDF9 generated a highly potent grow

177 Residues involved in amidase activation map to a previou

178 To pinpoint residues involved in DAB binding, we probed the structur

179 ilized site-directed mutagenesis to identify residues involved in substrate binding.

180 Phosphorylation of the p.Y783 residue is essential for the proximal activity of wild-t

181 annotated to indicate whether the amino acid residue is located within a hinge-bending region or with

182 lly that Katanin phosphorylation at a single residue is necessary and sufficient to target Katanin fo

183 Atomic force microscopy reveals the Y269 residue is required for proper DNA bending by APE1, prov

184 Identification of these residues is a novel understanding of resistant DQ associ

185 lso show that uniform patterning of aromatic residues is a sequence feature that promotes LLPS while

186 ) monosaccharide attached to protein Ser/Thr residues, is found on most cancer yet rarely detected in

187 mechanism dependent on its C-terminal lysine residue; its deletion led to modest reductions in comple

188 SAR studies on conserved residues (Leu25, His26, Val29, Pro30, Phe31, Pro32) show

189 irst employs stacked deep ResNets to perform residue-level ensemble error classifications at multiple

190 The residue-level information was used to develop phosphoryl

191 of magnitude lower than the maximum allowed residue limit (MRL) of the studied coccidiostats for chi

192 Mutations of CXCR4 residues located at a putative dimerization interface re

193 These residues lower the activation energy of reactions by per

194 Soil microbial residues may not only affect soil organic carbon (SOC) p

195 ed decrease in the contribution of microbial residues might be unfavorable for the stability of SOC i

196 We now combine the CsgG nanopore with the 35-residue N-terminal region of its extracellular interacti

197 More specifically, we show that acidic residues N-terminal to the substrate pTyr in EGFR and HE

198 Binding is sequence-independent with residues N13, R16, R17 and Q41 interacting exclusively w

199 y in the LD oil phase and positively charged residues near predicted hairpin hinges that become less

200 We proposed Graph-based Residue neighborhood Strategy to Predict binding sites (

201 the common view of a finely tuned allosteric residue network maintained under selection.

202 pling analysis (SCA), to identify coevolving residue networks (sectors) within the 23S ribosomal RNA

203 ids and nucleic acids (AAA + NA), tryptophan residues, nicotinamide adenine dinucleotide (NADH) and v

204 unfolding provides the number of amino acid residues nu participating in the unfolding reaction.

205 rapeseed phospholipid (RP) extracted from a residue of oil processing, stigmasterol (ST) and/or hydr

206 the (15)N chemical shift of A280 (the first residue of SP1) changes significantly, consistent with B

207 hydroxycinnamic acids attached to arabinosyl residues of arabinoxylan (AX), and certain BAHD acyltran

208 the addition of pCA to the arabinofuranosyl residues of AX in Setaria.

209 ls and bacteria enabled us to identify those residues of critical functional importance and revealed

210 Furthermore, it frequently binds to aromatic residues of OP-inhibited acetylcholinesterase (AChE) in

211 interactions between SUN and the C-terminal residues of the KASH peptide are similar in all five com

212 er leaflet and is coordinated by hydrophobic residues of the M and E transmembrane helices that form

213 ditionally, the glycine (G6) and lysine (K7) residues of the Walker A motif (-GPAGTG(6)K(7)S-) were f

214 that the N (alpha)-acetylation of the Thr-2 residue on EsxA, a post-translational modification that

215 irreversibly modify a proximal nucleophilic residue on the protein via reaction with an electrophile

216 and fungal biomass, and the clove oil flavor residues on malts were measured.

217 We show that acetylation of two key lysine residues on TULP3 by p300 increases TULP3 protein abunda

218 sue that may be overcome by targeting unique residues or binding pockets.

219 hat a major portion of this interkinase (571 residues out of 647 residues) when examined by single mo

220 teraction between a highly conserved Trp/Glu residue pair in the lower pore is detrimental to gating

221 our data suggest that to account for coupled residue pairs being in close structural proximity, both

222 tablished method for the analysis of organic residues, particularly lipids, from archaeological conte

223 Knowledge of protein-binding residues (PBRs) improves our understanding of protein-pr

224 s class of therapeutics is enfuvirtide, a 36-residue peptide drug that inhibits HIV entry/fusion.

225 e semi-rationally designed a series of seven-residue peptides that form hemin-binding catalytic amylo

226 Here, we show that constrained 31-residue-peptides ('msR4Ms') designed to mimic the CXCR4-

227 caused by filtering to the pixels around the residue pixels.

228 measuring stick ensuring placement of acidic residues precisely at the catalytic centre but also seem

229 as a model CXC chemokine, deletion of the X residue (Pro-10) had little to no impact on the folded c

230 Mutation of the individual cysteine residues produced stable Erv46 proteins that were partia

231 tent, with new binding modes, are 56- and 64-residue proteins (IC(50) ~ 0.16 nanograms per milliliter

232 In HLA-B*57:03, the charged POmega-2 residues protruded out from the cleft and directly impac

233 cken liver was developed, comprising a multi-residue QuEChERS (quick, easy, cheap, effective, rugged

234 A competitive inhibitor rich in arginine residues reduced the number of enzymatic cleavages to th

235 These two residues regulate the sequence of events, controlling SA

236 n vivo functional assays, verifies the FtsEX residues required for EnvC binding and experimentally te

237 uggest that the mechanisms driving microbial residue responses to increased N and P availability migh

238 s catalytic cycle and mapped the active site residues responsible for nucleoside selection, metal coo

239 Progressive deletion of N-terminal residues revealed an unexpected contribution of the rece

240 H inner rings through a selenocysteine (Sec) residue, revealed a thioredoxin-fold catalytic domain su

241 Mutagenesis of U-loop residues reveals its contribution to enzyme kinetics and

242 es rotation of the inner-gate backbone along residues S168-G169-I170.

243 es RBOHD's C-terminus and two phosphorylated residues (S862 and T912) affect RBOHD activity and stabi

244 a spiral conformation and interact with two-residue segments of substrate in the axial channel, as o

245 formatics, mutation and NMR, we identify a 7-residue sequence, named P1 (residues 36-42), that contro

246 y site-directed mutagenesis of the key CcmK2 residue Serine 39.

247 nder, we identified a triad of buried acidic residues shared by all three receptors, a feature distin

248 avage site of MuV F, because this amino acid residue shows a striking variability depending on the ge

249 ive and footprint broadly several amino acid residue side chains on the time scale of submilliseconds

250 We have previously shown that the ts residue signature of the Russian A/Leningrad/17/57 H2N2

251 us to predict the mutations at any specific residue site.

252 SILC quantitatively predicts residue-specific binding affinities to nanoparticles and

253 this study, an MAM method for examination of residue-specific glycan profiles of EPO was established.

254 We identified residues specifically important for beta(2)AR signaling,

255 and DNA appear to be mutually exclusive and residue substitutions in CdbA regions important for c-di

256 p1-specific S4-S5(L) peptide, containing the residues supposed to interact with S6(T) according to th

257 also identified an important H-bond between residues T176 and Y226 that is critical to transduce the

258 nd with Cys 215 in the ATP-binding pocket, a residue that is not present in human CLK1, thereby provi

259 e presence of a water-coordinating aspartate residue that limits esterase activity.

260 G6 variants identified a catalytic aspartate residue that probably acts as a general base.

261 ltransferase p300/CBP on lysine 152, the key residue that when polyubiquitinated results in the degra

262 tions in the HBoV1 capsid identified several residues that are critical for transduction, capsid asse

263 e-guided mutagenesis approach and identified residues that are important for ubiquitin binding.

264 Further, residues that define this geometry are enriched in genom

265 ents to identify two conserved phenylalanine residues that form an aromatic pathway whose dynamic rea

266 red for Nem1 catalytic function, to identify residues that govern formation of the Nem1-Spo7 complex.

267 We identified an insertion of eight residues that is conserved across arrestin-2 homologs, b

268 n that are potentially loss of function, and residues that modulate basal activity.

269 is characterized by two invariant histidine residues that play a critical role in catalytic activity

270 The identified VA-binding region contains residues that play roles in the mechanisms by which heat

271 his chemistry for the activation of tyrosine residues that project into solution from the N or C-term

272 ed primarily by interaction of DHMA with Tsr residue Thr156, which has been shown by genetic studies

273 However, the contributions of individual residues to specificity are usually poorly understood an

274 rotate by about 100 deg, exposing different residues to the channel pore in the open and closed stat

275 py topology and consistent with long-thought residue-to-residue interactions between actin and tropom

276 d by three conserved, surface-exposed lysine residues (triK), which were previously shown to be respo

277 scopy, we show that thiol groups of cysteine residues undergo S-glutathionylation and S-nitrosylation

278 Human isotypes do not contain the residues underlying this cooperative binding mode; conse

279 viral surface, covalent labeling of the Cys residues using a Cys-reactive label that masks epitope r

280 eraction is specifically mediated by PpMyoXI residue V1422.

281 We identify host-derived peptides of 4-11 residues, varying in both charge and composition, as the

282 For example, for in-tip TIE, only 3.6 mL of residues was generated (n = 12) over 60-240 mL in refere

283 These phosphorylated residues were dispensable for CHT7 function, but phospho

284 The NLS residues were mutated to alanine using a type A full-gen

285 APOE structures with various glycan residues were predicted.

286 o samples, the maximum concentrations of ETU residues were reached on the third and fifth days, respe

287 of this interkinase (571 residues out of 647 residues) when examined by single molecule force spectro

288 cterized by the movement of the histidine 98 residue, which is, after acidification, decoupled from t

289 A pair of histidine residues, which are conserved in coronavirus spike prote

290 egumain cannot cleave after glycosylated Asn residues, which enabled the robust identification and or

291 However, the simple removal of fucosyl residues, which results in reduced C1q binding and incre

292 liceosomal mutations that affect non-hotspot residues, whose potential functional contributions to di

293 anticipate that the identification of these residues will enable the broad interrogation of the kino

294 nd mammalian cells that a conserved cysteine residue within the Aurora A activation loop is crucial f

295 ion of the key T-cell receptor (TCR) contact residue within the epitope prevents diabetes development

296 persisted, indicating that yet-unidentified residues within CHT7 are also likely phosphorylated.

297 or correction of mis-annotated 28 C-terminal residues within the NADH dehydrogenase subunit 4.

298 Variation of key ligand residues within the short sequence was undertaken, and t

299 ses, seven of which cleave at specific basic residues within the trans-Golgi network, granules, or at

300 ugation of two proteins with unique cysteine residues yielding a nonhydrolyzable phosphonothiolate-li