ライフサイエンスコーパス: resistance

1 n dynamics, such as the spread of antibiotic resistance.

2 in, whereas its overexpression promotes drug resistance.

3 n of the genes flhC and ygaC conferred added resistance.

4 ng antitrypanosomal drugs and averting cross-resistance.

5 rpsA and panD genes were used to define PZA resistance.

6 etion led to modest reductions in complement resistance.

7 alignancies that typically succumb to taxane resistance.

8 tic interventions, directed against evolving resistance.

9 s the multitude of challenges in cancer drug resistance.

10 resistant tumors and a target for overcoming resistance.

11 threat due to DTG's high genetic barrier to resistance.

12 glucose utilization does not promote insulin resistance.

13 plasticity and genetic adaption, the keys to resistance.

14 ce systemic inflammation and reverse insulin resistance.

15 atment for people with HIV, with no emergent resistance.

16 elements (SGEs) can drive evolution of host resistance.

17 rganisms can be exploited to provide disease resistance.

18 for protein design and combatting antibiotic resistance.

19 pine is dependent on the degree of treatment-resistance.

20 argos with potential implications in therapy resistance.

21 with their use, including drug toxicity and resistance.

22 ion of Sm1(6), a gene associated with insect resistance.

23 arkably reverses already established insulin-resistance.

24 s a downstream effector of S6K1-mediated TKI resistance.

25 , most patients eventually relapse with drug resistance.

26 MR protein expression thereby increasing TMZ resistance.

27 stigate potential biomarkers of response and resistance.

28 or Avr2 recognition but contributes to basal resistance.

29 ptose biosynthesis, colonization, and stress resistance.

30 of inhibitors to this pathway is limited by resistance.

31 icroenvironment, metastasis, and therapeutic resistance.

32 anisms involved in stress tolerance and drug resistance.

33 dules participate partially in RKS1-mediated resistance.

34 -Y gastric bypass [RYGB]) surgery on insulin resistance.

35 ant part of efforts to address antimicrobial resistance.

36 ny ISGs, which confers broad viral infection resistance.

37 hich investigators attributed to doxycycline resistance.

38 o the maintenance and spread of antimalarial resistance.

39 without markedly causing peripheral insulin resistance.

40 fferent underlying sulfadoxine-pyrimethamine resistance.

41 rive evolutionary trade-offs with antibiotic resistance.

42 with characterized mechanisms of beta-lactam resistance, 180 clinical isolates from the Mayo Clinic a

43 at L-MT sample performed low charge transfer resistance (336.7 Omega cm(2)) that promotes the migrati

44 5) and tended to decrease pulmonary vascular resistance (-83 +/- 33 dynes; p = 0.07).

45 r soil microbiomes with the goal of inducing resistance above ground against herbivorous insects.

46 immune responses, which provide far greater resistance against challenge with nontyphoidal serovar S

47 t MDA5/MAVS signaling was essential for host resistance against pulmonary Aspergillus fumigatus chall

48 We measured SP-resistance allele frequencies in Malawian women particip

49 loss causes elevated blood glucose, insulin resistance and aberrant glucose output in lean mice.

50 aggrecan contribute to cartilage compression resistance and are necessary for healthy joint function.

51 ecrease in processing speed due to increased resistance and capacitance delay is a major obstacle for

52 ralizable activation site that mediates drug resistance and confirm its impact in BRAF, EGFR, HER2 an

53 The rise of antibiotic resistance and declining discovery of new antibiotics ha

54 ed invasive states associated with treatment resistance and defects in antigen presentation.

55 e repertoire of genes involved in antibiotic resistance and detoxification, including transporters, t

56 multiple growth factor pathways may postpone resistance and extend progression-free survival in many

57 ea, which contributed to low charge transfer resistance and high transduction activity towards the co

58 polysis and simultaneously triggered insulin resistance and hyperglycemia.

59 , plagued by the issues of excessive contact resistance and large hysteresis in ambient conditions.

60 nduced plant responses to herbivores promote resistance and often involve the perception of specific

61 ns, resulting in elevated pulmonary vascular resistance and right heart failure.

62 epeat protein repertoire involved in disease resistance and the characterization of Sm1(6), a gene as

63 to be related to the development of insulin resistance and type 2 diabetes.

64 vivo (euglycemic clamps and HOMA of insulin resistance), and the presence of nonalcoholic fatty live

65 mpairs beta-cell function, 2) causes insulin resistance, and 3) reduces metabolic clearance rate of i

66 d correlates of abnormal pulmonary pressure, resistance, and compliance and their association with in

67 ell proliferation, migration, invasion, drug resistance, and epithelial-mesenchymal transition (EMT).

68 such as CCR5 tropism, tier 2 neutralization resistance, and native trimer conformation.

69 ic NGFR signature predicts anti-PD-1 therapy resistance, and NGFR(hi) tumor fractions are associated

70 mi as a tool in the fight against antibiotic resistance, and our results demonstrate the specificity

71 common pathway for the spread of antibiotic resistance (AR) genes and bacteria into the environment.

72 rapies targeting mechanisms of immunotherapy resistance are likely needed.

73 CrCP and the resistance-area product (RAP) were obtained for each car

74 trictor responses of cerebral and mesenteric resistance arteries.

75 er adapt to structural plasticity in PR with resistance-associated amino acid substitutions by format

76 d-type Protease (PR(WT)) and highly-multi-PI-resistance-associated PR(DRV)(R)(P51) revealed that the

77 nhibitory concentration distributions of the resistance-associated variants (RAVs) for each drug were

78 nding of antibiotic mechanisms of action and resistance at inhibitory concentrations in the lab and i

79 whole-body glucose homeostasis, with insulin resistance being a major risk factor for metabolic disea

80 ears) with fasting glucose, insulin, insulin resistance, beta-cell function, and adiponectin at age 1

81 0A9 proinflammatory activity and proteolytic resistance but has little effect on S100A8/S100A9 antimi

82 metabolic remodeling did not improve insulin resistance, but induced fibrogenic genes and inflammatio

83 toid wasp Leptopilina boulardi, they evolved resistance by developing a more reactive cellular immune

84 mocytes, GCs paradoxically induced their own resistance by promoting upregulation of IL-7 receptor (I

85 We propose that social resistance can act as an agent of selection on key life-

86 ions, due to the shorter retention and large resistance changes.

87 However, regardless of the mechanisms of resistance, complete and durable therapeutic responses t

88 r sequencing, 78.6% (95% CI 76.1%-80.9%) had resistance-conferring mutations in the katG gene and 14.

89 It is predicted that the antibiotic resistance crisis will result in an annual death rate of

90 In light of the global antimicrobial-resistance crisis, there is an urgent need for novel bac

91 , drought resilience markedly increased, but resistance decreased, for gymnosperms between 1950-1969

92 The resistance detection strategies exhibited an even wider

93 ne beta-lactamases (SBLs) are key antibiotic resistance determinants in Gram-negative bacteria.

94 Improved rapid diagnosis and antimicrobial resistance determination, such as by whole-genome sequen

95 own mechanisms of reactions involved in drug resistance (drug extrusion, drug degradation, and DNA da

96 eucon' sponges with relatively high-pressure resistance due to a complex and narrow canal system, pum

97 nes that target the HA protein have suffered resistance due to destabilizing HA mutations that do not

98 isting understanding of fluoroquinolone (FQ) resistance due to mutations in the main drug targets, gy

99 IO) contribute to hyperleptinemia and leptin resistance, effects that are regulated by the endocannab

100 However, treatment resistance emerges inevitably.

101 sensor surface increased the charge transfer resistance, enabling detection of coliforms.

102 nd revealed the national distribution of the resistance-encoding plasmid.

103 n of both EGFR and STAT3 might overcome drug resistance encountered during treatment with single agen

104 eptor populations using mice with picrotoxin resistance engineered into receptors containing the delt

105 sity, arrhythmias, cardiac ischemia, insulin resistance, etc.

106 ion (and the ensuing hyperaminoacidemia) and resistance exercise (RE).

107 recede the insulin stimulus to cause insulin resistance, explaining why short-term, insulin-dependent

108 nization is more strongly affected by biotic resistance from residents than 3 degrees C of climate wa

109 l characterization of Pm41, a powdery mildew resistance gene derived from WEW, which encodes a coiled

110 eate comparative NLR resources, we conducted resistance gene enrichment sequencing (RenSeq) with sing

111 ese differences increased over time for both resistance gene prevalence measured by log-normalized ab

112 Fhb1-1 (aka WFhb1-c1) as a candidate for FHB resistance gene.

113 ecological niches of microbes and antibiotic resistance genes characterized by biofilm-forming and hu

114 st known for its regulation of Candida azole resistance genes such as MDR1, regulates other genes tha

115 TEM), and tetA genes are the main antibiotic-resistance genes that induce resistance patterns to cefo

116 The ST16 clone carried up to 14 resistance genes, including blaKPC-2 in an IncFIBpQIL pl

117 overed the presence of several antimicrobial resistance genes.

118 isease of wheat that can be controlled using resistance genes.

119 Antimalarial drug resistance has historically arisen through convergent de

120 ost factors important in phage infection and resistance have yet to be fully realized.

121 sceptible to high rates of acquired HIV drug resistance (HIVDR), but few studies include children ini

122 ntly, nutrient limitation shifted cavitation resistance in a species-specific and unpredictable manne

123 upregulates CHPT1 expression and confers Enz resistance in CRPC, suggesting that SE-mediated expressi

124 of FGFR1 attenuated hypoxia-induced EGFR TKI resistance in each line.

125 sable the most prevalent cause of antibiotic resistance in Gram-negative bacteria, i.e., the deactiva

126 The emergence of drug resistance in Helicobacter pylori has resulted in a grea

127 34499 risk variant with hypothalamic insulin resistance in men.

128 to reduced amino acid metabolism and insulin resistance in MHD patients.

129 spectively; P < .001) and confirmed ischemia resistance in NRF2-overexpressing HCC cell lines.

130 mplications for the assessment of cavitation resistance in other natural systems.

131 CHPT1 can be viable targets to overcome Enz resistance in PCa.

132 5 as a key mediator of acquired MEKi therapy resistance in PDAC and suggests a context for advancing

133 eveals a paracrine mechanism of antiandrogen resistance in prostate cancer amenable to clinical testi

134 n AMR to inform policies and to monitor drug resistance in S. Paratyphi, for which there is no vaccin

135 end toward increasing rates of ciprofloxacin resistance in S. sonnei, in addition to plasmid-mediated

136 yphoid vaccines and increasing antimicrobial resistance in Salmonella Typhi that have served to incre

137 = 0.01) suggesting a reversal of P450-based resistance in the absence of selection.

138 utants display modest but opposite M. oryzae resistance in the non-Piz-t background.

139 r understanding of the drivers of carbapenem resistance in the Philippines, while also serving as the

140 e and TCT decreased the frequency of aspirin resistance in this group.

141 strongly associated with markers of insulin resistance in vivo (euglycemic clamps and HOMA of insuli

142 We identify distinct mechanisms of resistance, in which HUWE1 loss increases RAD51 levels t

143 potential microbial reservoirs of macrolide resistance including the ermX, ermF, and msrD genes.

144 as treatment response and emergence of drug resistance: inference based on genomic, transcriptomic,

145 t-effective development of valuable colistin resistance inhibitors.

146 Insulin resistance (IR) precedes the development of type 2 diabe

147 With the development of insulin resistance (IR), there is a compensatory increase in the

148 HIV drug resistance is a major threat to achieving long-term vira

149 show that in vitro development of tamoxifen-resistance is associated with increased sensitivity to t

150 etic diversity, and mechanisms of carbapenem resistance is lacking.

151 Maintenance and persistence of antimicrobial resistance is likely to vary across different body sites

152 How this resistance is mediated is poorly understood, particularl

153 landscape of those genes with respect to FQ resistance is simple.

154 cy and substrate specificity leading to drug resistance is unclear.

155 Cancer, a disease that is prone to drug resistance, is in principle susceptible to such traps.

156 in addition to plasmid-mediated azithromycin resistance, is of significant public health concern with

157 MNV infection, suggesting that the cause of resistance lies in the entry step of MNV infection.

158 enriched for strains that acquired multidrug resistance loci, encoding enzymes that confer resistance

159 ferent classes is widely accepted as optimal resistance management.

160 evelopment of metabolic syndrome and insulin resistance, manifests when triglyceride (TG) input in th

161 Resistance mapping revealed a druggable site formed by t

162 The resistance marker dhps A581G has been associated with re

163 revious model simulations assuming invariant resistance may have underestimated the impacts of drough

164 Multidrug resistance (MDR) in cancer arises from cross-resistance

165 We reported the frequency of multidrug resistance (MDR)(resistance to ampicillin, cotrimoxazole

166 from a single patient harbors more than one resistance mechanism, and the plasticity between multipl

167 fly populations differ in E. muscae-specific resistance mechanisms as well as generic defences effect

168 chanism, and the plasticity between multiple resistance mechanisms could restrict the effectiveness o

169 nial activity and to mitigate ROS1-intrinsic resistance mechanisms have demonstrated clinical efficac

170 ts with advanced HCC by evaluating potential resistance mechanisms to AR-targeted therapy.

171 Laboratories not characterized for specific resistance mechanisms, and 128 isolates with CFDC MICs o

172 h smear-positive pulmonary TB with isoniazid resistance mediated by an inhA mutation were randomized

173 However, resistances mediated by pattern recognition receptors (P

174 Known resistance mutations to targeted therapies were numerica

175 iplexed identification of dozens of HIV drug-resistance mutations.

176 Multidrug efflux systems belonging to the resistance-nodulation-division (RND) superfamily are ubi

177 get-site resistance (TSR) and nontarget-site resistance (NTSR) mechanisms have evolved to most herbic

178 One mechanism of resistance observed in around 10-20% of these patients i

179 Here, we describe the extent of resistance of E. dermatitidis to acute gamma-radiation e

180 ormed a cohort study in which the daptomycin resistance of E. faecium isolated from rectal swabs from

181 ly demonstrated to enhance the antimicrobial resistance of Escherichia coli.

182 wn challenges in molecular junctions: series resistance of the leads, poor interface conductance, and

183 rbon electrodes is limited by the high ionic resistance of the macropores in the electrodes.

184 c modifications are closely involved in drug resistance of tumor cells.

185 However, the impact of low-frequency RPV resistance on virologic outcome during subsequent antire

186 glucose tolerance, protects against insulin-resistance onset and remarkably reverses already establi

187 The therapeutic profile as well as the resistance onset were characterized and a multiscale sto

188 iferation pathways accomplish a similar drug resistance outcome.

189 ocardin-related transcription factor (nMRTF) resistance pathway that amplifies noncanonical Gli1 acti

190 filtrate expressed higher levels of adaptive resistance pathways.

191 diagnostic tests which can fully describe TB resistance patterns is a major challenge in ensuring tha

192 main antibiotic-resistance genes that induce resistance patterns to cefotaxime, amoxicillin, and tetr

193 to identify quality measures for diagnosis, resistance patterns, and treatment efficacy.

194 ics of ITx allograft rejection and treatment resistance, peripheral blood samples and intestinal allo

195 eas SAP2 overexpression results in increased resistance, probably owing to high-affinity binding of S

196 ctiveness of corn rotation for mitigating Bt resistance problems did not differ significantly between

197 ategies to mitigate the extreme and multiple resistance provided by these mechanisms are required in

198 Additionally, pulmonary vascular resistance (PVR) 2.2 to 3.0 WU, considered previously to

199 teria from the FRAIL scale: fatigue, reduced resistance, reduced aerobic capacity, having >=5 illness

200 ne families in J. hindsii, including disease resistance-related wall-associated kinase (WAK), Cathara

201 tic indicator in T-ALL, the mechanisms of GC resistance remain poorly understood.

202 e likely to achieve complete cures, acquired resistance remains an obstacle to their success as well.

203 Development of resistance remains the key obstacle to the clinical effi

204 The data included antibiotic resistance results of bacterial cultures from hospitaliz

205 stigate phenotypic inducibility of meropenem resistance, short read sequencing was performed using an

206 one third of the BC(1):F(3) lines showed FHB resistance similar to their M4 parents.

207 toward a more comprehensive understanding of resistance spread.

208 further efforts to implement ultrasensitive resistance testing in routine settings.

209 Dried blood spots (DBS)-based drug resistance testing, widely studied for HIV-1, has not be

210 egaplasmids contained genes for tetracycline resistance [tet(O)], the Type IV secretion system, conju

211 lopidogrel had a higher incidence of aspirin resistance than all patients treated with aspirin alone

212 y that enables the emergence of antiandrogen resistance through heterogeneous mechanisms.

213 ifferences are likely to impact colonization resistance through lantibiotic expression or intestinal

214 Hypomagnesemia has been linked to insulin resistance through reduced tyrosine kinase activity of t

215 Here we show that resistance to 5FC in Cryptococcus deuterogattii is acqui

216 ter the resident Mphi subset composition and resistance to a subsequent infection.

217 Influential physicians willing to overcome resistance to advances were able to bring medical practi

218 the frequency of multidrug resistance (MDR)(resistance to ampicillin, cotrimoxazole, and chloramphen

219 This study identifies a novel mechanism of resistance to anti-PD-1/PD-L1 immunotherapy mediated by

220 tems are necessary for metabolic regulation, resistance to antibiotics and antimicrobials, pathogenes

221 Bacterial resistance to antibiotics in this clinical setting furth

222 metabolic reprogramming, immune suppression, resistance to apoptosis, angiogenesis, metastasis, and i

223 The emergence of resistance to available antileishmanial drugs advocates

224 re were 90 ART-experienced participants with resistance to both efavirenz and lamivudine, 32 (35.6%)

225 Here we analyzed resistance to Bt toxin Cry1Ac in a field-derived strain

226 nt NHEJ with implications for development of resistance to cancer therapy.

227 report that interferon (IFN) signals convey resistance to CDC-induced pores on macrophages and neutr

228 otes hypovascularity, immunosuppression, and resistance to chemo- and immunotherapies.

229 drives aggressive TNBC biology by promoting resistance to chemotherapy and inducing a prometastatic

230 ed with high tumor grade, poor survival, and resistance to chemotherapy.

231 ype but also revealed a potential intestinal resistance to chlamydial spreading.

232 li in domestic swine in China that conferred resistance to colistin, an antibiotic of last resort use

233 Binding of FH increases meningococcal resistance to complement-mediated killing.

234 The widespread resistance to Cry1 and Cry2 proteins in H. zea will chal

235 esults from forces required to overcome soil resistance to deformation.

236 dramatically enhanced (sometimes >1000 fold) resistance to degradation by four different nucleases, b

237 enes whose loss causes either sensitivity or resistance to DNA-damaging agents.

238 correlated with phenotypic AMR testing, and resistance to empirical antimicrobials was associated wi

239 stomatous and a major target for desiccation resistance to enhance shelf life.

240 armacological properties, including improved resistance to enzymatic degradation, while remaining non

241 3K pathway is essential to overcome Melanoma resistance to fotemustine.

242 lymphoblastic leukemia (T-ALL), and although resistance to GCs is a strong negative prognostic indica

243 cells that overexpressed ZIP4 had increased resistance to gemcitabine, 5-fluorouracil, and cisplatin

244 Here, we show that resistance to glyphosate in the studied population from

245 highly accurate and robust classification of resistance to HIV protease inhibitors.

246 of second-generation antiandrogens, acquired resistance to hormone therapy remains a major challenge

247 gulator, ToxR, was important for V. cholerae resistance to hydrogen peroxide.

248 However, primary or secondary resistance to immunotherapy prevents benefits in a signi

249 tic tool is leading to the profiling of drug resistance to inform clinical practice and treatment dec

250 n between 5-HT(3A) and the chaperone protein resistance to inhibitors of choline esterase (RIC-3).

251 er-expressed in multiple cancers and confers resistance to ionizing radiation and chemotherapeutic dr

252 notyping to assess their potential to confer resistance to LET.

253 assembling block copolymers exhibit superior resistance to macroscopic deformation in comparison to t

254 e created trametiglue, which limits adaptive resistance to MEK inhibition by enhancing interfacial bi

255 uced spontaneous tumorigenesis and increased resistance to Myc-driven lymphoma and Eml4-Alk-driven lu

256 ne response could contribute to differential resistance to NDV in inbred Fayoumi and Leghorn lines.

257 esistance loci, encoding enzymes that confer resistance to nonrelated antibiotics, including extended

258 as a therapeutic strategy to overcome tumor resistance to osimertinib.

259 r in AIVs with substitutions known to impart resistance to other NAIs.

260 sulted from the site morphology having a low resistance to overwash, as opposed to being directly imp

261 omal alterations associated with response or resistance to PD-1 blockade.

262 Resistance to Phytophthora crown rot in University of Fl

263 TLs significantly (P < 0.05) associated with resistance to Phytophthora crown rot were detected on ch

264 clinically viable strategies for overcoming resistance to platinum chemotherapy in lung adenocarcino

265 r NHFs stimulate proliferation of and confer resistance to radiation therapy of PDAC.

266 est that ToxR plays an important role in the resistance to reactive oxygen species through the regula

267 west scan speeds showed comparable corrosion resistance to rolled and annealed super duplex stainless

268 nent of humoral innate immunity, involved in resistance to selected pathogens and in the regulation o

269 amma-producing ILCs also improve endometrial resistance to sexually transmitted C. trachomatis infect

270 s viral infections, IRF3 is also involved in resistance to some bacterial infections, in anticancer i

271 heritable gene expression state that enables resistance to stress.

272 nd integrity of the nuclear envelope and its resistance to stresses found that both mutations result

273 resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent c

274 Understanding tumor resistance to T cell immunotherapies is critical to impr

275 in treating patients with advanced BC after resistance to TAM and aromatase inhibitors develops.

276 In this study, we profiled resistance to the anti-influenza drug laninamivir in AIV

277 ual body motion reduced the initial in-place resistance to the perturbation.

278 and nucleotides for biosynthesis, conferring resistance to therapies targeting anabolic pathways.

279 carrying mutations in genes responsible for resistance to therapy has led to a Darwinian model of cl

280 OM) of gram-negative bacteria confers innate resistance to toxins and antibiotics.

281 is implicated in tumorigenesis and acquired resistance to treatments.

282 The continued emergence of antibiotic resistance, together with our increasing understanding o

283 ntrained individuals performed contralateral resistance training with moderate and low volume for 12

284 Both target-site resistance (TSR) and nontarget-site resistance (NTSR) me

285 ence are generally associated with treatment resistance, unfavorable prognosis, and the infiltration

286 to CARD, we are able to summarize predicted resistance using the information included in CARD, ident

287 By adding these resistance variants to CARD, we are able to summarize pr

288 d determine previously undescribed and novel resistance variants.

289 o understand how the genetic architecture of resistance varies across time and geographic space, we q

290 an important mechanism conferring tamoxifen resistance via both ERalpha dependent and independent pa

291 Of note, in addition to macrolide resistance, virtually all emm12 isolates had a single am

292 The role of S6K1 in TKI resistance was determined in in vitro gain-and-loss of f

293 Adipocyte-extrinsic insulin resistance was observed in liver and muscle.

294 he effect of the PPHD knockout on antibiotic resistance was phenocopied in bacteria exposed to atmosp

295 Rates of acquired drug resistance were significantly higher among patients rece

296 Low-level class-wide resistance, which often goes undetected in the clinic, m

297 robust hysteretic behaviour of the graphene resistance with an externally applied out-of-plane displ

298 electrolytes demonstrate a small interfacial resistance with good cycling performance at 35 degrees C

299 he teeny phenotype, characterized by insulin resistance with late failure of insulin production, seve

300 r prevent a novel mechanism of acquired MEKi resistance, with clinical implications for MPNST patient

301 xazole, and chloramphenicol), extensive drug resistance (XDR) (MDR plus non-susceptible to fluoroquin