ライフサイエンスコーパス: resistin

1 n (hRTN(+/-)(/-)) but are deficient in mouse resistin.

2 tissues from adult rat hearts overexpressing resistin.

3 ng 12.1% and 8.5% of variance in circulating resistin.

4 /EBPbeta) expression vectors with or without resistin.

5 an articular chondrocytes were cultured with resistin.

6 al and high-molecular-weight adiponectin and resistin.

7 The RETN gene encodes the adipokine resistin.

8 eptor, also prevented the effects of central resistin.

9 due to reduced expression and circulation of resistin.

10 ate pituitaries expressed leptin/adiponectin/resistin.

11 may be transduced, in part, by its impact on resistin.

12 ormal T cell expressed and secreted PDGF and RESISTIN.

13 fold, angiotensinogen 3-fold, leptin 2-fold, resistin 4-fold, and adiponectin 4-fold; P<0.01 compared

14 experiments showed that pre-incubation with resistin (40 ng/ml) significantly impaired the ability o

15 ale + PVAT 97.3 +/- 0.9% vs. female + PVAT + resistin([40ng/ml]) 36.8 +/- 2.3%).

16 onectin concentrations, as well as 16% lower resistin, 41% lower CRP, 19% lower sE-selectin, and 24%

17 ximally adjusted model, each SD increment in resistin (7.45 ng/ml) was associated with a 26% increase

18 Resistin, a cysteine-rich adipocytokine, proposed as a l

19 Plasma levels of resistin, a proinflammatory cytokine and uremic toxin, w

20 Resistin, a protein linked with inflammation and cardiom

21 d inflammation and suggest that hypothalamic resistin action can contribute to hyperglycemia in type

22 that bi-directional changes in hypothalamic resistin action have dramatic effects on GP and proinfla

23 Conversely, central antagonism of resistin action markedly diminished the ability of circu

24 Together, these results suggest that resistin action on NPY neurons is an important regulator

25 The proinflammatory leptin and resistin adipokines have been described as possible link

26 We compared serum concentrations of leptin, resistin, adiponectin, and visfatin in 167 RA patients a

27 al and circulating levels of adipocytokines (resistin, adiponectin, leptin, tumor necrosis factor [TN

28 ly improved by the simultaneous inclusion of resistin, adipsin, and total adiponectin (c-statistic: 0

29 Resistin, adipsin, and total adiponectin provided increm

30 Higher plasma levels of resistin, adipsin, and total adiponectin were associated

31 roperties of 4 plasma adipocytokines, namely resistin, adipsin, leptin, and total adiponectin, with r

32 amined whether the human-specific variant of resistin affects neutrophil activation and the severity

33 Resistin also stimulated the activation of p70(S6K), a d

34 Serum levels of resistin, an adipose tissue-derived adipokine, are incre

35 tion was assessed by measurement of secreted resistin, an azurophilic granule marker, and by determin

36 Growing evidence indicates that resistin-an obesity-related cytokine-is upregulated in b

37 Resistin and acetaminophen levels were comparable in bot

38 We tested the association of the adipokines resistin and adiponectin with incident heart failure.

39 mainly influenced the circulating levels of resistin and adiponectin, whereas both obesity and perio

40 The data further show that repression of resistin and angiotensinogen expression involves recruit

41 lso results in elevated circulating level of Resistin and development of hepatic steatosis.

42 of cytokine signaling-3 (Socs3), a target of resistin and hepcidin implicated in insulin resistance.

43 ship between inflammatory increases in human resistin and insulin resistance.

44 he role of three key adipokines-adiponectin, resistin and leptin-as potential predictors of response

45 ment of secreted azurophilic granule protein resistin and profiling of the secretome, using mass spec

46 Change in diet score was unrelated to resistin and several cytokines.

47 l growth factor, myeloperoxidase, prolactin, resistin and soluble tumor necrosis factor alpha recepto

48 asma GIP, GLP-1, glucose, insulin, glucagon, resistin, and acetaminophen levels.

49 HPCs express adiponectin, resistin, and GLP-1, which become available to resident

50 PC-expressing adipokines (e.g., adiponectin, resistin, and glucagon-like peptide 1 [GLP-1]) were coun

51 romoters of white fat-specific genes such as resistin, and is abolished in the genetic absence of CtB

52 Resistin, and its closely related homologs, the resistin

53 fat transplants contained increased leptin, resistin, and monocyte chemoattractant protein-1 compare

54 Serum glucose, insulin, IL-6, resistin, and OVA-specific IgE levels were quantified.

55 n sensitivity and the levels of adiponectin, resistin, and serum RBP (RBP4).

56 Expression of galectin-12, resistin, and SREBP-1 in SZ95 sebocytes was confirmed by

57 a caused hypoglycemia in mice lacking murine resistin, and this was attenuated in BAC-Retn mice.

58 4-h serum interleukin-6, C-reactive protein, resistin, and tumor necrosis factor-alpha levels by 3-29

59 nd serum adipocytokine (leptin, adiponectin, resistin, and visfatin) concentrations were determined i

60 necrosis factor-alpha, adiponectin, leptin, resistin, and vitamin D were measured at baseline.

61 fat genes ("visceral white"), including the resistin, angiotensinogen, and chemerin genes, in additi

62 Resistin antagonizes insulin action in mouse, making it

63 Adiponectin and resistin are recently discovered adipokines that may pro

64 ignificantly less inflammatory cytokines and resistin as compared with MIF(+/+) mice and failed to de

65 n concentrations and lower concentrations of resistin, as well as biomarkers of inflammation, endothe

66 (24 h) with the following: 1) purified human resistin at various concentrations, with and without lov

67 Resistin, at physiological levels observed in human obes

68 erial artificial chromosome containing human resistin (BAC-Retn), whose expression was similar to tha

69 ciation kinetics of hRes subunits pointed to resistin being a molecular chaperone.

70 ory states, we generated mice lacking murine resistin but transgenic for a bacterial artificial chrom

71 Resistin by itself was able to induce acute kidney injur

72 A significant difference was observed in GCF resistin concentrations from group 1 versus group 2 (P =

73 Furthermore, recombinant human resistin could bind misfolded proteins only.

74 Only resistin (cut-off value 13.7 ng/ml) and IL-6 (cut-off va

75 Here we demonstrate that in normal mice resistin delivered in the lateral cerebral ventricle inc

76 Furthermore, resistin diminished statin-mediated up-regulation of the

77 ltration rate) using the lowest third of the resistin distribution as the referent, the hazard ratios

78 e other ancestry populations, we showed that resistin does not seem to increase insulin resistance an

79 Interestingly, we also show that resistin effects were abolished in TLR4 knockout mice an

80 sitize neutrophils to LPS stimulation, human resistin enhanced neutrophil extracellular trap formatio

81 Resistin expression in HPCs increased in pNAFLD and was

82 ubsequent western blot validation identified resistin expression to be increased approximately 2-fold

83 LV resistin expression was markedly elevated in POH, mildly

84 genes including tumor necrosis factor alpha, resistin, FABP4, and PPARgamma.

85 elationship between the CRD of PCSK9 and the resistin family is not observed in primary sequence comp

86 HF diet-induced elevations of plasma leptin, resistin, fed-state and fasting insulin and increased ex

87 lasma peptide YY (PYY), leptin, ghrelin, and resistin for all subjects.

88 d the expression of known adipogenic factors resistin, galectin-12, sterol response-element-binding p

89 To better understand how mouse resistin gene (Retn) expression is restricted to fat tis

90 two SNPs were significantly associated with resistin gene (RETN) mRNA levels in white blood cells fr

91 ited to the transcription loci and regulates resistin gene expression upon insulin stimulation.

92 In addition it causes IR, higher hepatic resistin gene expression, and up-regulation of hepatic i

93 ent study was initiated to determine whether resistin has additional roles in GIP-regulated adipocyte

94 Resistin has been associated with inflammation and risk

95 Resistin has been suggested to be involved in the develo

96 Resistin has diverse effects on gene expression in human

97 obesity, recent studies also suggested that resistin has proinflammatory properties.

98 roup box (HMGB)-1, B7 Homolog 1, S100A4, and resistin have been detected in tissues of dermatomyositi

99 Because human and mouse resistin have distinct patterns of tissue distribution,

100 , plasminogen activator inhibitor-1 (PAI-1), resistin, hepatocyte growth factor, interleukin-6 (IL-6)

101 ed for the qualitative analysis of the human resistin homodimer from normal (healthy) plasma samples.

102 wing a distinct structural similarity to the resistin homotrimer, a small cytokine associated with ob

103 Resistin (HR, 1.88; 95% confidence interval [CI], 1.16-3

104 We earlier reported that human resistin (hRes), a trimer, was resistant to heat and ure

105 Human resistin (hRetn) is an immune cell-derived protein that

106 resistin mice that exclusively express human resistin (hRTN(+/-)(/-)) but are deficient in mouse resi

107 i) serum hormone concentrations (leptin and resistin), ii) adipose tissue mRNA expression of inflamm

108 The hormone resistin impairs the response to insulin in liver and ot

109 ted with circulating levels of the adipokine resistin in a lipolysis-dependent manner.

110 lating higher molecular weight structures of resistin in both rodent and human serum.

111 The findings suggest a role for resistin in human disease and a novel pathway to heart f

112 d by antibody-immunoprecipitation removal of resistin in human serum, which decreased serum stimulati

113 However, the function of resistin in humans is enigmatic.

114 Emerging evidence suggests a role for resistin in inflammation and vascular dysfunction, which

115 The quantitatively important role of human resistin in LDLR expression was demonstrated by antibody

116 These findings indicate a novel role for resistin in mediating sex-dependent vascular function in

117 a central role in the genetic regulation of resistin in monocytes along with promoter methylation.

118 or galectin-12 and SREBP-1 in the nuclei and resistin in the cytoplasm of basal sebocytes, and stearo

119 e results strongly support the role of human resistin in the development of insulin resistance in inf

120 udy is to estimate and compare the levels of resistin in the gingival crevicular fluid (GCF) in healt

121 learly identify TLR4 as the binding site for resistin in the hypothalamus and bring new insight into

122 p-regulation of the LDLR by 60%, implicating resistin in the relative ineffectiveness of statins in s

123 an altered adipokine response (i.e., higher resistin increase and an adiponectin fall), and hepatocy

124 and did not alter LH/FSH/TSH-release; and 3) resistin increased ACTH-release and did not alter PRL/LH

125 ally, we report that intracerebroventricular resistin increased plasma FGF21 levels and downregulated

126 Furthermore, resistin increased serine phosphorylation of insulin rec

127 normal-weight bone explant with recombinant resistin increased the Type I collagen alpha1/alpha2 rat

128 n of primary OA osteoblasts with recombinant resistin increased Wnt signalling activation, osteoblast

129 zation analyses did not provide evidence for resistin increasing insulin resistance, body mass index,

130 Central resistin induced expression of proinflammatory cytokines

131 to elucidate the mechanisms associated with resistin-induced cardiac hypertrophy and myocardial insu

132 ith rapamycin or mTOR siRNA attenuated these resistin-induced changes.

133 trally mediated mechanisms partially control resistin-induced expression of TNF-alpha, IL-6, and SOCS

134 ranscriptional up-regulation are involved in resistin-induced gene expression in human chondrocytes.

135 ht into the molecular mechanisms involved in resistin-induced inflammation and insulin resistance in

136 NF-kappaB and C/EBPbeta were involved in the resistin-induced up-regulation.

137 These data demonstrate that resistin induces cardiac hypertrophy and myocardial insu

138 We show that chronic intracerebroventricular resistin infusion downregulated both hypothalamic and he

139 In the current study, we report that chronic resistin infusion in the lateral cerebral ventricle of n

140 In agreement, central resistin inhibited Akt phosphorylation and increased the

141 A key mechanism by which human resistin inhibited LDLR levels was by increased cellular

142 Resistin inhibited neutrophilic-differentiated NB4 cell

143 Expression of human resistin inhibited the activation of AMP-activated prote

144 Furthermore, rm-resistin-injected normal chow-fed mice showed upregulate

145 receptors (TLR)2, TLR4, and TLR9, as well as resistin, interleukins (IL)-1beta, IL-4, and IL-6 and ox

146 These findings provide clear evidence that resistin is a clinically relevant endogenous ligand for

147 These results reveal for the first time that resistin is a highly attractive therapeutic target in am

148 Resistin is a key cytokine associated with metabolic and

149 Resistin is a polypeptide hormone that was reported to b

150 rease in resistin was also observed; because resistin is a potent pro-inflammatory compound, this dec

151 Resistin is associated with local and systemic inflammat

152 We recently reported that resistin is expressed in diabetic hearts and promotes ca

153 Resistin is greatly elevated during acute kidney injury,

154 In vitro, resistin is induced by angiotensin II and induces CTGF i

155 tes, independent of body mass index, whereas resistin is not.

156 at the human homolog of RELMalpha, human (h) resistin, is upregulated in macrophage-like inflammatory

157 ne in this region is the structural gene for resistin, itself.

158 onectin, an insulin-sensitizing hormone, and resistin, known to promote insulin resistance, constitut

159 luding tumor necrosis factor, interleukin-6, resistin, leptin, and monocyte chemotactic protein-1, an

160 ' side of RETN were strongly associated with resistin levels (all minor alleles associated with highe

161 of hypertension, but the association between resistin levels and incident hypertension is unknown.

162 us acute kidney injury still showed elevated resistin levels and inhibited neutrophilic-differentiate

163 We examined the association between plasma resistin levels and the risk for incident hypertension a

164 Resistin levels are increased in CP and T2DM.

165 riant as likely causal affecting circulating resistin levels as a cis-eQTL increasing RETN expression

166 ) and the NDST4 gene (4q25), associated with resistin levels at a genome-wide significant level, best

167 s to infer genetic causality for circulating resistin levels by performing genome-wide association st

168 Only admission resistin levels could serve as an early predictor for SA

169 In this study, we observed that high serum resistin levels in breast cancer patients positively cor

170 -wide association (GWA) study on circulating resistin levels in individuals of European ancestry draw

171 After adjustment for potential confounders, resistin levels in the highest tertile conferred a 75% h

172 In stratified analysis, resistin levels in the highest tertile significantly inc

173 In conclusion, higher plasma resistin levels independently associate with an increase

174 Hence, GCF resistin levels may be considered as a potential inflamm

175 atin; and 2) obese human serum with elevated resistin levels or serum from which resistin was removed

176 all the samples were analyzed together, GCF resistin levels positively correlated with GI, PD, PI, R

177 association of SNP -420C/G (rs1862513) with resistin levels remained significant (P = 0.0009) but wi

178 for these biomarkers and C-reactive protein, resistin levels remained significantly associated with i

179 lammatory and endothelial biomarkers, plasma resistin levels significantly correlated with IL-6, solu

180 GCF (4 muL) was collected and analyzed for resistin levels using an enzyme-linked immunosorbent ass

181 ariate model without body mass index, higher resistin levels were associated with a higher risk for d

182 In serum, resistin levels were higher whereas adiponectin levels w

183 irculating insulin, adiponectin, leptin, and resistin levels were measured in 36 patients with advanc

184 Additional variants regulating resistin levels were upstream of RETN with genes PCP2, S

185 We found that BAC-Retn mice have circulating resistin levels within the normal human range, and simil

186 in the 3' region of RETN are associated with resistin levels, and one of them is also associated with

187 Framingham Offspring Study participants for resistin levels, glycemic phenotypes, and incident diabe

188 in RETN and tested associations with plasma resistin levels, risk of diabetes, and glycemic traits.

189 Associations of RETN with plasma resistin levels, type 2 diabetes, and related metabolic

190 e for most of the variability in circulating resistin levels.

191 be involved in the regulation of circulating resistin levels.

192 lipopolysaccharide markedly increased serum resistin levels.

193 (which have elevated levels of the cytokine resistin-like beta, RELMbeta, and are extremely sensitiv

194 sensitivity and a marked reduction in serum Resistin-like molecule (RELM) alpha, a multifunctional c

195 of Arginase 1, chitinase-like molecules, and resistin-like molecule (RELM) alpha/FIZZ1; however, the

196 differentiate into goblet cells that secrete resistin-like molecule (RELM) beta.

197 in inflammatory zone (FIZZ) 2, also known as resistin-like molecule (RELM)-beta, belongs to a novel c

198 Resistin-like molecule (RELM)alpha belongs to a family o

199 Resistin-like molecule alpha (Relm-alpha) is a secreted

200 Here, we show that resistin-like molecule alpha (RELMalpha), a small secret

201 ulomatous inflammation, increased numbers of resistin-like molecule alpha(+) cells, and enhanced coll

202 so known as found in inflammatory zone 1 and resistin-like molecule alpha, belongs to a novel class o

203 that expressed a smooth muscle cell mitogen, resistin-like molecule alpha, but surprisingly, there wa

204 protein product of the most promising gene, resistin-like molecule alpha, demonstrated a significant

205 Goblet cell numbers and resistin-like molecule beta (RELM-beta) expression were

206 3 production in IL-33-deficient mice impairs resistin-like molecule beta (RELMbeta) expression and eo

207 The secreted goblet cell-derived protein resistin-like molecule beta (RELMbeta) has been implicat

208 Here, we show that resistin-like molecule beta (RELMbeta) is a bactericidal

209 Resistin-like molecule beta (RELMbeta) is a goblet cell-

210 Basal and DSS-induced production of resistin-like molecule beta (RELMbeta) was substantially

211 ed expression of the antihelminthic proteins resistin-like molecule beta and mucin 5ac.

212 increase in secretion of goblet cell-derived resistin-like molecule beta into the intestinal lumen.

213 Resistin-like molecule beta is important in mucosal defe

214 In rodents, resistin-like molecule-alpha (RELMalpha, also known as H

215 Moreover, the expression of resistin-like molecule-alpha, a target of IL-13 signalin

216 und in inflammatory zone 1 (FIZZ1/Retnla), a resistin-like molecule.

217 Resistin-like molecules (RELMs) are highly expressed fol

218 istin, and its closely related homologs, the resistin-like molecules (RELMs) have been implicated in

219 ore, HIF2alpha induced the expression of the resistin-like molecules alpha and beta (RELMalpha and be

220 Although adipocyte-derived murine resistin links insulin resistance to obesity, the role o

221 in, insulin resistance, leptin, adiponectin, resistin, liver function enzymes, fetuin-A, body composi

222 Upon STAT3 silencing, leptin and resistin lost their ability to activate PCSK9.

223 Plasma tumor necrosis factor-alpha, resistin, macrophage chemoattractant protein-1, and adip

224 Thus, human resistin may link insulin resistance to inflammatory dis

225 log deleted on chromosome ten) expression by resistin may mediate the inhibitory effects.

226 Our results suggest that human resistin may play an important contributory role in enha

227 e tissue, including leptin, adiponectin, and resistin, may influence osteoarthritis though direct joi

228 e of the molecular regulators of leptin- and resistin-mediated transcriptional induction of PCSK9.

229 In LPS-induced acute lung injury, humanized resistin mice demonstrated enhanced production of proinf

230 , experiments were performed using humanized resistin mice that exclusively express human resistin (h

231 To investigate the role of human resistin on glucose homeostasis in inflammatory states,

232 The effects of central resistin on glucose production as well as hepatic expres

233 t we believe to be a novel site of action of resistin on GP and inflammation and suggest that hypotha

234 The effect of resistin on primary OA osteoblasts was determined by ana

235 The infusion of either resistin or an active cysteine mutant in the third cereb

236 istrated with recombinant mouse resistin (rm-resistin), or exposed to media from Lmo4-overexpressed 3

237 3), lower serum IL-(P = 0.0022), lower serum resistin (P = 0.0043), lower serum OVA-specific IgE (P =

238 atin (P = 0.06), adiponectin (P = 0.55), and resistin (P = 0.98) showed no association with the HOMA-

239 is study, our goal was to determine if human resistin plays a role in regulating the uptake of athero

240 lin resistance to obesity, the role of human resistin, predominantly expressed in mononuclear cells a

241 Resistin promotes both inflammation and insulin resistan

242 Here, we investigated whether central resistin promotes insulin resistance through the impairm

243 Additionally, central resistin promotes the activation of the serine kinases J

244 We also found evidence for a QTL influencing resistin protein levels (LOD score 5.3) on chromosome 14

245 However, the resistin receptor and the molecular mechanisms mediating

246 did not affect the expression of leptin and resistin receptors or that of PCSK9.

247 NP rs13144478 with NDST4 gene expression and resistin-related disease.

248 Marked variation in resistin release and the neutrophil secretome profile we

249 newly defined family of proteins, including resistin, Relm-beta, and Relm-gamma.

250 ogenic factor (HIMF) is a member of the FIZZ/resistin/RELM family of proteins that we have shown to h

251 A high resistin response was triggered exclusively by SpeB-nega

252 centrations of TNF-alpha, IL-6, adiponectin, resistin, retinol binding protein-4, or intraabdominal f

253 ha, IL-6, high-molecular-weight adiponectin, resistin, retinol binding protein-4, or intraabdominal o

254 was positively associated with expression of resistin (RETN) and negatively associated with expressio

255 Unlike expression of Retn in mouse, human resistin (RETN) is expressed primarily in macrophages.

256 chromosome 19p13 affecting the abundance of resistin (RETN) mRNA in the omental adipose tissue of ba

257 Rhox5-regulated genes are insulin 2 (Ins2), resistin (Retn), and adiponectin (Adipoq), all of which

258 In addition, the resistin-rising allele of the TYW3/CRYZ SNP rs3931020, b

259 tocytes administrated with recombinant mouse resistin (rm-resistin), or exposed to media from Lmo4-ov

260 tro adipogenesis, transcription of Retn, and resistin secretion in 3T3-L1 cells.

261 ur results suggest a regulatory role of Lmo4-resistin signaling in weight cycling, indicating a cross

262 he interplay between adiponectin, FGF21, and resistin signaling pathways during the onset of insulin

263 eukin-8, monocyte chemoattractant protein-1, resistin, soluble interleukin-1 receptor I, soluble inte

264 alysis showed the expression of galectin-12, resistin, SREBP-1, and stearoyl-CoA desaturase mRNAs in

265 Leptin and resistin stimulated GH-release, a response that was bloc

266 Circulating resistin stimulates endogenous glucose production (GP).

267 ted that levels of the adipokines leptin and resistin, the inflammatory marker myeloperoxidase (MPO),

268 protein metabolism, is induced by leptin and resistin through the involvement of the inflammatory pat

269 n resistance onset orchestrated by a central resistin-TLR4 pathway that impairs adiponectin signaling

270 rkedly diminished the ability of circulating resistin to enhance GP.

271 In addition to the ability of resistin to sensitize neutrophils to LPS stimulation, hu

272 ime, to our knowledge, the direct binding of resistin to Toll-like receptor (TLR) 4 receptors in the

273 Resistin-treated human articular chondrocytes increased

274 Resistin treatment also decreased plasma adiponectin lev

275 Central resistin treatment inhibited insulin-dependent phosphory

276 transcription inhibitor actinomycin D after resistin treatment or with the NF-kappaB inhibitor IKK-N

277 d in Retn(+/-) and Retn(-/-) adipocytes, but resistin treatment rescued LPL responsiveness to GIP.

278 with the NF-kappaB inhibitor IKK-NBD before resistin treatment.

279 In HepG2 cells, leptin and resistin up-regulated PCSK9 gene and protein expression,

280 Overexpression of resistin using adenoviral vector in neonatal rat ventric

281 Here, we show that recombinant human resistin was able to protect the heat-labile enzymes cit

282 A ketamine-induced decrease in resistin was also observed; because resistin is a potent

283 Central infusion of resistin was associated with neuronal activation in the

284 In 3T3-L1 cells, resistin was demonstrated to be a key mediator of GIP st

285 Resistin was detected in the GCF of all patients.

286 The RELM family member Resistin was expressed in human skin, was induced by vit

287 Resistin was found to promote epithelial-mesenchymal tra

288 The serum concentration of resistin was higher in overweight/obese OA patients, com

289 Resistin was initially defined based on its insulin resi

290 rage, TGF-beta was elevated (P = 0.0052) and resistin was lower (P = 0.0052) in patients compared wit

291 Although resistin was recently found to modulate insulin resistan

292 elevated resistin levels or serum from which resistin was removed via antibody-immunoprecipitation.

293 Plasma resistin was significantly higher in patients with septi

294 Another RELM family member, human resistin, was also bactericidal, suggesting that bacteri

295 Increased circulating concentrations of resistin were associated with incident heart failure, ev

296 nsity lipoprotein-cholesterol (LDL-CHL), and resistin were higher in the raspberry group.

297 iation studies and fine-mapping analyses for resistin were performed in 5621 African-ancestry individ

298 PYY, ghrelin, and resistin were significantly elevated in cases and fell d

299 several adipokines, including Retn (encoding resistin), were found altered by weight cycling.

300 flammatory proteins CCL3 and CCL4 as well as resistin, which augments monocyte-endothelial adhesion.