ライフサイエンスコーパス: resolving power

1 er parameters with regard to sensitivity and resolving power.

2 e unfolding mechanism that provides a robust resolving power.

3 e-of-flight (TOF) instrument with lower mass resolving power.

4 rom information misinterpretation due to low resolving power.

5 y swept on signal-to-noise ratios (SNRs) and resolving power.

6 ra measured with high mass accuracy and high resolving power.

7 ignments must account for the peak shape and resolving power.

8 nces, because of limitations in the spectral resolving power.

9 onstrating the benefits of improved mobility resolving power.

10 c chemistry mainly due to its very high mass resolving power.

11 out encountering the field-dependent loss of resolving power.

12 mpositions were evaluated with complementary resolving power.

13 0 ion mobility resolving power and 2000 mass resolving power.

14 er magnetic fields are used to increase mass resolving power.

15 ity separation, with concomitant increase in resolving power.

16 cy encoded in the analyte gradient increases resolving power.

17 the IMS drift tube and reduction in the IMS resolving power.

18 ted to <1% in order to maintain instrumental resolving power.

19 ficities to define changes with the greatest resolving power.

20 significantly reduced, resulting in improved resolving power.

21 not show a proportional increase in the mass resolving power.

22 although technical biases may put a limit on resolving power.

23 ime (t) and this at unprecedented speeds and resolving power.

24 h mass measurement errors <5 ppm and ~40 000 resolving power.

25 ge reduction methods and (ii) DMAs of higher resolving power.

26 y being improved, especially in terms of the resolving power.

27 same nominal mass and overlapped at previous resolving powers.

28 Estimates of spatial resolving power (~17 cycles/degree) for the temporal are

29 pic resolution up to m/z-value 12,000 (e.g., resolving power 39,000 at m/z-value 12,000) providing mo

30 Given its location and spatial resolving power (~6 cycles/degree), this specialization

31 S and TWIMS, with DTIMS demonstrating higher resolving power (70-80) than TWIMS (30-40).

32 In addition to mass resolving power, absorption mode offers higher mass accu

33 mples with increased multiplexing at a given resolving power afforded by the addition of mass differe

34 It was confirmed by comparing the resolving powers after and before resolution recovery.

35 ectrometry continues to be the leader in the resolving power among all mass spectrometry methods.

36 ction accuracies yielded optima at 0.005 for resolving power and 2.3 for the root transformation.

37 tests have shown obtaining 100 ion mobility resolving power and 2000 mass resolving power.

38 sma lysozyme was conducted by utilizing high resolving power and an EIC window fitting to the protein

39 Phase correction further improves the resolving power and average absolute deviation by 1.3-fo

40 he workflow and taking advantage of the high resolving power and dynamic range of a Fourier transform

41 The increases in resolving power and ensuing peak resolution are especial

42 in commercial mass spectrometers with higher resolving power and faster scanning capabilities have ex

43 However, both resolving power and ion transmission showed a dependence

44 vels of ion gate depletion, which limit both resolving power and ion transmission.

45 ct ion mobility spectrometers with both high resolving power and low limits of detection.

46 required for spectral acquisition of a given resolving power and mass accuracy decreases linearly wit

47 lecular characterization still requires mass resolving power and mass accuracy provided by FT-ICR MS.

48 the unique advantage of delivering high mass resolving power and mass accuracy simultaneously, making

49 necessary to use instrumentation with a high resolving power and mass accuracy when studying complex

50 n two MS/MS experiments while characteristic resolving power and mass measurement accuracies were mai

51 e method is demonstrated to have significant resolving power and peak capacities far in excess of wha

52 tron resonance (FT-ICR) MS affords ultrahigh resolving power and provides high-accuracy mass measurem

53 the fractionator was modified to improve the resolving power and reproducibility of separation.

54 exchange separations, while having excellent resolving power and robustness, are product specific and

55 vements in IMS-MS instrumentation, e.g., IMS resolving power and sensitivity, are highly desirable.

56 he integration of corrected spectra improves resolving power and signal-to-noise ratio.

57 eversed phase gradient, providing additional resolving power and significantly improved desorption of

58 imaging has recently led to a revolution in resolving power and tissue contrast in biomedical imagin

59 valuated and classified using different mass resolving powers and noninteger root transformations.

60 guities, while taking into consideration the resolving power (and its decay) of different mass analyz

61 erizing suitable sample flow rates, temporal resolving power, and analyte concentrations.

62 it of detection (LOD), linear dynamic range, resolving power, and collision cross section (Omega) are

63 specific optimum voltage, gate pulse width, resolving power, and now CRM for each ion.

64 the centimeter scale, with high performance, resolving power approaching 100 or higher.

65 Resolving power approaching the theoretical limit was ac

66 erations that limit achievable ion isolation resolving power are discussed.

67 ns, sophisticated analytical tools with high resolving power are required for the characterization of

68 In other words, the achieved resolving powers are 4 times higher than those provided

69 tures resulted in a leveling of the measured resolving power as a function of pressure.

70 hile a greater frequency swept increases the resolving power at the expense of SNR.

71 Both geometries provide IMS resolving powers at the theoretical limit (R ~ 58), show

72 on Orbitrap platforms at a minimum of 60,000 resolving power (at 400 m/z), and we demonstrate accurat

73 Because of its resolving power, AUC is a favorite application, despite

74 as utilized, TWIMS was found to operate at a resolving power between 40 and 50, confirming the previo

75 his metabolite class can only be achieved at resolving power beyond 65,000.

76 aise the mobilities of all ions and thus the resolving power beyond that previously feasible, while a

77 a nonclassical imaging mechanism with super-resolving power beyond the Rayleigh limit.

78 ns provide unprecedentedly high ion mobility resolving powers but are ultimately limited in their ion

79 R MS) offers superior mass accuracy and mass resolving power, but its moderate throughput inhibits br

80 sented here, it was possible to increase the resolving power by 60% from 60 to 95 without increasing

81 the reactant ion peak, a significant loss of resolving power by a factor of up to 1.4 was observed du

82 have been made to further increase the mass resolving power by increasing the magnetic field and usi

83 ion 2D MS, which increases the precursor ion resolving power by reducing the precursor ion m/z range,

84 servations show that it improved the average resolving power by roughly 40-150% and revealed unresolv

85 Estimates of spatial resolving power calculated using cone peak densities are

86 Simulation and theoretical resolving power calculations were made to validate the e

87 However, a gain in mass resolving power can also be realized by phase correction

88 a drift length of 9242.03 cm) values of the resolving power can exceed 300 with a maximum resolving

89 distinguishes C. jejuni from C. coli, has a resolving power comparable to that of multilocus sequenc

90 the field of microscopy by providing higher resolving power compared to their optical counterpart.

91 irmed that in addition to the improvement on resolving power, compared to the conventional magnitude-

92 s, their separations in helium, where higher resolving powers could also be achieved, revealed distin

93 there exists an optimum voltage above which resolving power decreases.

94 ference in the gas-phase CCS and a CCS-based resolving power definition (CCS/DeltaCCS).

95 The mass resolving power depends on the uncertainties in both qua

96 Interestingly, the apparent resolving power depends strongly on the identity of the

97 At high pressures, however, resolving power did not increase as much as theory predi

98 ce microscopy has made a quantum leap in its resolving power due, in large part, to advancements over

99 MS) system has been created that maintains a resolving power efficiency of 80% regardless of the pres

100 ne IMS ranged from 42 to 54, yielding an IMS resolving power efficiency, defined as R m/ R c x 100%,

101 ble without tilting the specimen.Beyond high resolving power, electron microscopy can be used to stud

102 This high mass resolving power ensures that closely spaced peaks at the

103 A "conditional" resolving power equation is introduced that can be used

104 e need to use IMS devices with high mobility resolving power for better separation of isomers and to

105 tly upon genomic coverage and the consequent resolving power for discerning somatic mutations.

106 To date, this technology affords limited resolving power for discerning subtle pathological chang

107 ce mass spectrometry offers the highest mass resolving power for molecular imaging experiments.

108 The maximal measured resolving power for our small, ambient-pressure stand-al

109 es the FAIMS separation capability, with the resolving power for peptides and peak capacity for prote

110 ular metabolites within 20 min and excellent resolving power for polar molecules including many isoba

111 h wider than necessary, thereby limiting the resolving power for precursor ions and the accuracy of t

112 increase in MS acquisition rate per unit of resolving power for signal detection periods typically e

113 Detection limits determined at the optimal resolving power for the environmental contaminants range

114 The estimated resolving power for the ESI-HPIMS used in this study was

115 ht) intersect, this method affords excellent resolving power for the functional analysis of neural ci

116 ve the best overall performance at different resolving powers for chemical profiling from a multileve

117 In conclusion, the most effective mass resolving powers for profiling analyses of metabolite ri

118 can be used to quickly approximate realistic resolving powers for specific instrumental operating par

119 Also, the resolving power gains are often at the expense of speed,

120 ixtures comprising up to 75% He have enabled resolving power >100 that permits separation of numerous

121 e-selected ion monitoring (H-SIM) mode (mass resolving power, >12,500 fwhm) was proposed monitoring t

122 ionization-induced artifacts or limited mass resolving power, hindering accurate molecular characteri

123 e and detection of H(-) and D(-) at low mass resolving power, (ii) a primary beam intensity of 100 pA

124 performance characteristics of FT-ICR; mass resolving power improves linearly, while mass accuracy a

125 Overall, we observe that instrumental resolving power improves with increasing cycle numbers;

126 An increase in the resolving power in 2D NMR spectra is obtained by collaps

127 Peak anatomical spatial resolving power in both species is approximately 10-11 c

128 21T is demonstrated for the first time: mass resolving power in excess of 1 600 000 (at m/z 400), roo

129 h increasing cycle numbers; at 100 cycles, a resolving power in excess of 1000 can be achieved.

130 y the effect of space charge on ion loss and resolving power in IMS systems.

131 The estimated upper limit of spatial resolving power in juvenile H. portusjacksoni was 3.14 c

132 addressed the necessity of instrumental mass resolving power in terms of clinical diagnosis and progn

133 14,271 cells/mm(2), upper limits of spatial resolving power in the temporal area ranged from 25 to 2

134 Resolving powers in excess of 300 are obtainable with th

135 Although diffusion theory predicts that IMS resolving power increases with the square root of the vo

136 f ion residence time in FAIMS, which affects resolving power independently of ion desolvation after t

137 ith multiple metabolite ions, requiring high resolving power instrumentation or derivatization to cir

138 Here, we report ultrahigh resolving power ion isolation by SWIFT on a 21 T Fourier

139 A further increase in the mass resolving power is desirable mainly for two reasons: wit

140 The experiment shows that the resolving power is proportional to the harmonic order an

141 eloped and tested a TM-IMS, and the measured resolving power is R = 55.

142 A chromatography existing concept of resolving power is used to differentiate between peak re

143 After the separation axis (and corresponding resolving power) is converted to cross section space, it

144 With sufficiently high mass resolving power (m/Deltam(50%) approximately 400,000, in

145 spholipids at sub-ppm mass accuracy and high resolving power (m/Deltam50% = 200 000 at m/z 400) at 1

146 instrumentation that is capable of high mass resolving power, mass accuracy, and dynamic range.

147 e mass spectrometry (FTICR MS) delivers high resolving power, mass measurement accuracy, and the capa

148 classes of biomolecules, not requiring high-resolving power MS for quantitation and being relatively

149 ompatibility of IEF-SPLC processing and high resolving-power MS analysis with results showing ~7.0 fe

150 issociation (ExD) tandem MS analysis and the resolving power needed to resolve isobaric fragments.

151 n order to predict the required ion mobility resolving power needed to separate the various isomer cl

152 a function of pressure, with higher optimal resolving powers obtained at higher voltages, as predict

153 obility separations benchmark at a CCS-based resolving power of >300 that is sufficient to differenti

154 aluated in this study, a uniform field-based resolving power of 100 was predicted to be sufficient to

155 sma source and reflection zone plates with a resolving power of 1000 and a time resolution of 0.5 ns.

156 s spectrometer source, and the expected mass resolving power of 100000 to 400000 is achieved.

157 MS cell of 10.7 cm length has demonstrated a resolving power of 102 when operated at 2.5 atm.

158 ass measurement accuracy of 1 ppm and a mass resolving power of 120000 in analysis of protein digests

159 Ion isolation resolving power of 175 000 (m/Deltam) is demonstrated by

160 for the first time, a fair comparison of the resolving power of 1D- and 2DLC under realistic conditio

161 An upper bound on the resolving power of 2.7 +/- 0.3 mum of the LWFA source in

162 28 cm long OMS instrument is shown to have a resolving power of 20 and is capable of attomole detecti

163 uracy typically less than 300 ppb rms, and a resolving power of 200,000 (m/Delta m50% at m/z 400) is

164 -resolution ion mobility spectrometer with a resolving power of 250 and an UV ionization source enabl

165 In intact protein analysis, the average resolving power of 340,000 across the baseline-resolved

166 he shift frequency to yield a device limited resolving power of 400 (m/Deltam).

167 n molecular weight from 8 to 150 kDa, with a resolving power of 677 000 achieved for transients of ca

168 ength), we estimated upper limits of spatial resolving power of 7 cycles/deg (temporal area), 6.6 cyc

169 tube with a tritium ionization source and a resolving power of 70.

170 ength), we estimated upper limits of spatial resolving power of 8 cycles/deg (temporal area, 1,800 ce

171 than 26,000 assigned peaks, Fourier-limited resolving power of 800,000 at m/z 500 (6.6 s transient d

172 A spatial resolving power of 9.8 mum, well below the optical limit

173 The addition of high resolution TIMS (resolving power of 90-220) to ultrahigh resolution FT-IC

174 58 passes around the cIM, with an estimated resolving power of 920 for these triply charged species,

175 e 3D convex surfaces with at least twice the resolving power of a conventional 2D diffraction grating

176 r, we present a new approach to increase the resolving power of a drift time IMS without employing hi

177 The ability to tune the resolving power of a mobility-based separation by varyin

178 ely 1% of the previously needed time, with a resolving power of about half that for "macroscopic" uni

179 The combination of high resolving power of an FTICR analyzer and matrix subtract

180 r 2 mum for biomolecules) with the high mass-resolving power of an Orbitrap (>240,000 at m/z 200).

181 esolving power can exceed 300 with a maximum resolving power of approximately 400.

182 S instrument is highlighted, with a mobility resolving power of approximately 750 demonstrated for 10

183 f coherent transfer functions, the underling resolving power of axially structured geometries is inve

184 e metasurface, we demonstrate a displacement resolving power of better than 1 nanometer (lambda/800,

185 In addition, the resolving power of CEX is often considered to be limited

186 sely spaced tags is possible due to the high resolving power of current day mass spectrometers.

187 reveals an important discrepancy between the resolving power of current forensic analytical chemistry

188 t a microfluidic device that can enhance the resolving power of CZE analysis by generating a pressure

189 a computational framework for estimating the resolving power of dHRM technology for defined sequence

190 The resolving power of differential ion mobility spectrometr

191 But the biochemical resolving power of fluorescence microscopy is not as wel

192 orescence features maximizes the biochemical resolving power of fluorescence microscopy, thereby prov

193 The ultrahigh resolving power of FT-ICR MS combined with sSEC fraction

194 Benefiting from the ultrahigh resolving power of FT-ICR, we isotopically resolved 31 d

195 With the high resolving power of FTICR MS, it was possible to differen

196 omb, or 'astro-comb', is well matched to the resolving power of high-resolution astrophysical spectro

197 ed expressions that predict the ion loss and resolving power of IMS systems as a function of input ch

198 drift tube has the potential to increase the resolving power of IMS, but operation at low temperature

199 evelopments have significantly increased the resolving power of ion mobility separators.

200 n array of taxonomic ranges and extended the resolving power of ITS towards earlier nodes of phylogen

201 mporal ERP measurement robustly improved the resolving power of key signatures characteristic of the

202 However, the greater resolving power of LC x LC comes at the price of higher

203 But the ability to employ the resolving power of MCD to follow changes at transition m

204 theoretically could be, given the parentage-resolving power of molecular markers and the huge sizes

205 cell, it has become possible to achieve the resolving power of more than 10 million at m/q = 1000 wi

206 While the mass accuracy and resolving power of orbitraps have been extensively docum

207 spectrometry (FTICR MS) with an average mass resolving power of over 500 K (M/DeltaM(fwhm)).

208 y advances have established the accuracy and resolving power of paleobiological information derived f

209 mance drift tubes, the dual IMS reaches high resolving power of R = 90 with detection limits in the l

210 n important initial step that highlights the resolving power of surface charge-based HPLC techniques.

211 sence significantly compromises the temporal resolving power of the auditory system.

212 The high mass resolving power of the instrument allows unambiguous ide

213 began in the 1800s, but until now the great resolving power of the laser scanning confocal microscop

214 Using nitrogen as a carrier gas, the resolving power of the nano-radial differential mobility

215 Taking advantage of the resolving power of the NST, we measure the cross-section

216 (LC-MS) method that capitalizes on the mass-resolving power of the orbitrap to enable sensitive and

217 ter sensitivity, higher recovery, and higher resolving power of the PLOT column resulted in the incre

218 The resolving power of the scanning endoscopic probe is suff

219 nces in the next few years will increase the resolving power of the technology to provide unprecedent

220 The high ion mobility resolving power of the TIMS analyzer allowed the identif

221 To test the resolving power of these novel probes, we generate micro

222 repertoire sequencing method, improving the resolving power of this low-cost technology.

223 At a mobility resolving power of ~100, 14 out of 22 structures showed

224 bsolute deviation of 0.36 ppm and an average resolving power of ~520 000 at m/z 6033 for the 26+ char

225 We argue that a resolving power of ~lambda/4000, the typical size of an

226 provides similar or better resolution (with resolving powers of >200 for multiply charged peptides)

227 the near-infrared spectrum (corresponding to resolving powers of 10(4)-10(5)).

228 For example, resolving powers of 170,000 and 70,000 were obtained in

229 ease B (m/z-value 14,900) were measured with resolving powers of 62,000 and 61,000, respectively.

230 ment, the 3D printed IMS is shown to achieve resolving powers of between 24 and 50 in positive ion mo

231 Resolving powers of between 29 and 42 were achieved in n

232 The apparent resolving powers of native-like ions measured using SLIM

233 Mobility resolving powers of up to 17 are measured for the tetraa

234 Resolving powers of up to ~560 were achieved using all f

235 pic ion peak ([M]) after SLIM SUPER IMS with resolving powers of ~400-600.

236 A parametric study on the dependence of IMS resolving power on drift length, voltage across drift ce

237 describe the influence of mass spectrometry resolving power on profiling metabolomics experiments.

238 ow rates as low as 500 nL/min, with temporal resolving power on the order of 3 min, with analyte load

239 ntribute to separation efficiency, including resolving power, orthogonality, and sample loss.

240 f 90-220) to ultrahigh resolution FT-ICR MS (resolving power over 400k) permitted the identification

241 x 100%, of 56-74% of the maximal conditional resolving power possible.

242 with TSI's GEMMA have suffered from limited resolving power, possibly because of imperfections in ei

243 The ultrahigh resolving power provided by Fourier transform ion cyclot

244 It provides a resolving power R > 60 in IMS mode, and R > 40 in each s

245 s wavelength-measurement technique with high resolving power R = 3.4 x 10(6) (i.e., resolution < 0.3

246 ll as in the position of the acyl chain with resolving power ( R) up to ~410 ( R ~ 320 needed on aver

247 nd the high mass-accuracy (<20 ppm) and mass-resolving power (R>5500) of the time-of-flight mass spec

248 This report determined and compared CRM, resolving power (R(m)), and diffusion-limited conditiona

249 dicated that HRdm performs with an effective resolving power (R(p)) of between 180 to 250 for the hig

250 on of scan ratio enhancing both the mobility resolving power (R) and resolution (r), fingerprints fro

251 At a resolving power (R) exceeding 250, many new features, ot

252 the duplex tags and effectively reducing the resolving power requirement compared to previously repor

253 of above-ambient pressure on ion mobility on resolving power, resolution, and ion current were invest

254 uantifications are possible at 240K and 480K resolving powers, respectively.

255 using OSA-TIMS-FT-ICR MS with high mobility resolving powers (RIMS up to 250), high mass accuracy (<

256 , mass spectral data were acquired with high resolving power (RP > 100,000-190,000) and mass accuracy

257 back and forth: (i) full scan with ultrahigh resolving power (RP = 120,000, mass accuracy </=3 ppm),

258 ions were detected within 1 min with an IMS resolving power (Rp) of approximately 100.

259 Here we examine the relationship among resolving power (Rp), resolution (Rpp), and collision cr

260 meter (Thermo Fisher Scientific, CA, USA) at resolving power settings of 15k (7.8 Hz) up to a maximum

261 Increasing the IM resolving power should allow finer structural informatio

262 We demonstrate high mass resolving power single-acquisition FT-ICR-MS analysis of

263 ions substantially higher than a single-peak resolving power suggested.

264 e in terms of both detection sensitivity and resolving power than is currently available by other sep

265 -fold better mass accuracy and 2-fold higher resolving power than similar 7 T systems at the same sca

266 igh-order harmonics, which offer higher mass resolving power than that for fundamental frequency comp

267 The device demonstrates better mass resolving power than the radially ejecting halo ion trap

268 y: it can resolve neutral species, provide a resolving power that increases markedly for very large m

269 y, HDX MS experiments employed mass spectral resolving powers that afforded only one peak per nominal

270 Despite the improved mass resolving power, the measured peak widths are still domi

271 Because of limited resolving power, the present FAIMS units are more suitab

272 echanism in O. wendtii, providing sufficient resolving power to detect the stimuli.

273 tron resonance mass spectrometry affords the resolving power to determine an unprecedented number of

274 The technique utilizes the high resolving power to produce images from thousands of ions

275 This allows previously unattainable resolving powers to be achieved utilizing a small (10.7

276 cialized, their utility was limited by FAIMS resolving power, typically approximately 10-20.

277 cement technique with c-LSFM to increase the resolving power under a large field-of-view, we demonstr

278 ately 30 residues employing trapped IMS with resolving power up to approximately 340, followed by tim

279 otein ubiquitin with the same peak width and resolving power up to approximately 400 as for peptides.

280 ntial ion mobility spectrometry (IMS) with a resolving power up to R approximately 300.

281 This increased the resolving power up to the theoretical maximum for every

282 with over an order of magnitude higher mass resolving power (up to 140 000).

283 The resolving power (up to 400) is five times the highest pr

284 Absorption mode spectra offer superior mass resolving power (up to a factor of 2), mass accuracy, an

285 Higher mass resolving power usually requires longer scanning times,

286 The effect of helium upon IMS resolving power was also studied by introducing a He/N2

287 athematical relationship relating the CCS to resolving power was developed in order to predict the re

288 Close to ideal IMS resolving power was maintained over a significant range

289 In previous work, the mass resolving power was modest, around 30-40.

290 A noticeable decrease in the IMS resolving power was observed for ion populations of >10,

291 sing the novel TREC technology; over 420,000 resolving power was observed on melittin [M + 4H] (4+) s

292 Higher resolving power was observed using the atmospheric press

293 An optimal resolving power was obtained at a specific voltage as a

294 The resolving power was optimized with the shift frequency t

295 nal, R c, and actual (or measured), R m, IMS resolving powers were determined and compared for a smal

296 Optimal MS resolving powers were determined to be 240K for labeled

297 all IMSs suffer from the consequences of low resolving power when compared to laboratory systems.

298 alyses of two DiPyrO-labeled samples at 100K resolving power, whereas 3-plex and 6-plex quantificatio

299 ents can be resolved thanks to the ultrahigh resolving power, which also allows extracted ion chromat

300 The ion mobility resolving power with ESI (30-35) is comparable to that o