ライフサイエンスコーパス: respiratory chain

1 gnal, which required an intact mitochondrial respiratory chain.

2 assembly of Complex III of the mitochondrial respiratory chain.

3 ctron-accepting complex of the mitochondrial respiratory chain.

4 a role in the assembly of the mitochondrial respiratory chain.

5 t nematocidal activity via the mitochondrial respiratory chain.

6 eases due to a biochemical deficiency of the respiratory chain.

7 he operation of the protein complex I of the respiratory chain.

8 which encode components of the mitochondrial respiratory chain.

9 e (CcO) is the last electron acceptor in the respiratory chain.

10 energy disruptor targeting complex I of the respiratory chain.

11 ighly potent inhibitors of the mitochondrial respiratory chain.

12 hat GLDH is associated with complex I of the respiratory chain.

13 idation, tricarboxylic acid (TCA) cycle, and respiratory chain.

14 l, which is generated by the activity of the respiratory chain.

15 slation, or a component of the mitochondrial respiratory chain.

16 their putative positions in the aerobic iron respiratory chain.

17 sential to the function of the mitochondrial respiratory chain.

18 en species, a byproduct of the mitochondrial respiratory chain.

19 hemoglobin, myoglobin, and components of the respiratory chain.

20 a multisubunit, membrane-bound enzyme of the respiratory chain.

21 electron transfer through the mitochondrial respiratory chain.

22 ral essential inner membrane proteins of the respiratory chain.

23 m effect is dysfunction of the mitochondrial respiratory chain.

24 sis (Mtb) depends on energy generated by its respiratory chain.

25 in eukaryotes, function in the mitochondrial respiratory chain.

26 ters and energy generating components of the respiratory chain.

27 xpressed, localized, and integrated into the respiratory chain.

28 ucleotide, which are further oxidized by the respiratory chain.

29 ons as a redox-driven proton pump in aerobic respiratory chains.

30 totrophs but can also be involved in aerobic respiratory chains.

31 ich is reflected in the composition of their respiratory chains.

32 sue showed reduced mitochondrial density and respiratory chain activity along with increased mitophag

33 Respiratory chain activity and mitochondrial content.

34 o abnormal mitochondrial membrane potential, respiratory chain activity and morphology.

35 The increased respiratory chain activity is related to the mitochondri

36 following treatment, and the morphology and respiratory chain activity of mitochondria within these

37 creased by treatment with JP4-039, while the respiratory chain activity was increased by this antioxi

38 stent changes in cellular iron handling, and respiratory chain activity was unaffected.

39 ions, and their ablation results in impaired respiratory chain activity, increased oxidative stress,

40 The branched character of their respiratory chains allows bacteria to do so by providing

41 tivity of UCP1, UCP3, and complex III of the respiratory chain alongside with UCP2 inhibition.

42 s exhibit abnormalities of the mitochondrial respiratory chain, among other biochemical findings.

43 s have a lower spare reserve capacity in the respiratory chain and are more susceptible to oxidative

44 The effect of chemical inhibition of the respiratory chain and ATP synthesis differed between bas

45 oduction of hydrogen peroxide was a block in respiratory chain and diversion of electrons from NADH o

46 tochondrial energy metabolism, including the respiratory chain and each enzymatic step of the tricarb

47 efects in all complexes of the mitochondrial respiratory chain and in the F-ATP synthase, while adult

48 roton motive force (Deltap) generated by the respiratory chain and increases thermogenesis.

49 de inhibited complex IV of the mitochondrial respiratory chain and induced apoptosis.

50 s activity is linked to the operation of the respiratory chain and is essential for the development o

51 d in electron shuttling in the mitochondrial respiratory chain and is now also recognized as an impor

52 ion will expand our understanding of how the respiratory chain and mitochondrial ROS influence whole

53 mitochondria, are components of the cellular respiratory chain and of the photosynthetic apparatus of

54 work underscores the connection between the respiratory chain and one-carbon metabolism with implica

55 GO terms related to oxidoreductase activity, respiratory chain and other mitochondrial-related proces

56 esigned to directly target the mitochondrial respiratory chain and prevent excessive reactive oxygen

57 ed pathway essential for the function of the respiratory chain and several mitochondrial enzyme compl

58 ncluding key metabolic pathways, such as the respiratory chain and the photosystems, as well as the t

59 ochondria-localized proteins involved in the respiratory chain and the tricarboxylic acid cycle.

60 olamine are required for the activity of the respiratory chain and therefore to maintain the membrane

61 mately maintained by the proton pumps of the respiratory chain, and Ca(2+) binding to matrix buffers.

62 emonstrate the intrinsic plasticity of Mtb's respiratory chain, and highlight the challenges associat

63 etabolism; a partial Kreb's cycle; a reduced respiratory chain; and a laterally acquired rhodoquinone

64 observation that cells lacking a functional respiratory chain are auxotrophic for pyruvate, which se

65 mutants in nuclear-encoded components of the respiratory chain are non-viable, emphasizing the import

66 he physical arrangement of the mitochondrial respiratory chain as a compact physical entity (the soli

67 of increasing the electron flux through the respiratory chain as a strategy to induce oxidative stre

68 ame communities identified components of the respiratory chain as important for the metabolism of NAE

69 n contrast, the inhibition of the chlamydial respiratory chain at mid-stage of the infection cycle de

70 disrupting the flow of electrons through the respiratory chain at the cytochrome bc1 complex, causing

71 energetics were modulated sequentially using respiratory chain-ATP synthase substrates (ethanol and A

72 is the most commonly observed mitochondrial respiratory chain biochemical defect, affecting the larg

73 participates in the dynamics of TIM21 during respiratory chain biogenesis and is specifically require

74 Mitochondrial respiratory chain biogenesis is orchestrated by hundreds

75 Thus, attenuation of the mitochondrial respiratory chain by MCJ in macrophages exquisitely regu

76 2 and Rcf3 increases oxygen flux through the respiratory chain by up-regulation of the cytochrome c o

77 ll and exemplify how the plant mitochondrial respiratory chain can act as a multifunctional electron

78 group of disorders manifesting with impaired respiratory chain capacity; yet, only a few have been li

79 piration and calcium retention capacity, and respiratory chain complex activities and oxidative stres

80 in all patients tested and severe, combined respiratory chain complex activity deficiencies.

81 rial mass, without a concomitant increase in respiratory chain complex activity.

82 Protein translation, mitochondrial respiratory chain complex assembly, signal recognition p

83 All had biochemical evidence of multiple respiratory chain complex defects but no primary pathoge

84 showed normal YARS2 protein levels and mild respiratory chain complex defects.

85 tient presenting with combined mitochondrial respiratory chain complex deficiency.

86 AD9) is an assembly factor for mitochondrial respiratory chain Complex I (CI), and ACAD9 mutations ar

87 Deficiencies of mitochondrial respiratory chain complex I activity have been observed

88 Fanconi Syndrome results from mitochondrial respiratory chain complex I deficiency.

89 und to have profoundly decreased activity of respiratory chain complex I in muscle, heart and liver.

90 J is an endogenous negative regulator of the respiratory chain Complex I that acts to restrain mitoch

91 ein identified as an endogenous inhibitor of respiratory chain complex I.

92 Mtln decreases the activity of mitochondrial respiratory chain complex I.

93 ciates with the oncoprotein survivin and the respiratory chain Complex II subunit succinate dehydroge

94 We fed KD to mice with respiratory chain complex III (CIII) deficiency and prog

95 uronal loss, peripheral neuropathy, impaired respiratory chain complex III activity and aberrant mito

96 re neurological phenotypes and mitochondrial respiratory chain complex III deficiency.

97 reg) cell-specific ablation of mitochondrial respiratory chain complex III in mice results in the dev

98 specific biochemical defect of mitochondrial respiratory chain complex III, and explores the impact o

99 cts in mitochondrial cytochrome c oxidase or respiratory chain complex IV (CIV) assembly are a freque

100 ders can exhibit dysfunctional mitochondrial respiratory chain complex IV activity.

101 ndrial function, in particular mitochondrial respiratory chain complex IV or cytochrome c oxidase act

102 on, as well as organization of mitochondrial respiratory chain complex IV, mitochondrial organization

103 f cytochrome c oxidase (MTCO1), a subunit of respiratory chain complex IV, mitochondrial transcriptio

104 localized in mitochondria and interacts with respiratory chain complex IV, suggesting that Mb could b

105 nce and enzyme activity of the mitochondrial respiratory chain complex IV.

106 and the general depression of mitochondrial respiratory chain complex levels (including complex II)

107 Together, our data reveal that respiratory chain complex mRNA sequestration underlies t

108 sm for the preferential sequestration of the respiratory chain complex mRNAs by FUS that does not inv

109 of complex I (CI), the largest mitochondrial respiratory chain complex, remains enigmatic despite hug

110 dase (CCOX), an essential constituent of the respiratory chain complex.

111 dosis and evidence of multiple mitochondrial respiratory-chain-complex deficiencies in skeletal muscl

112 is broadly activates genes for mitochondrial respiratory chain complexes (MRCs) and fortifies MRC act

113 This in turn diminishes mitochondrial respiratory chain complexes and mitochondrial respiratio

114 veals that mitofusin-null cells downregulate respiratory chain complexes and mitochondrial ribosomal

115 mbalanced stoichiometry of the mitochondrial respiratory chain complexes and skin inflammation and su

116 Maxicircles encode components of respiratory chain complexes and the mitoribosome.

117 decrease of AAC1 protein levels and loss of respiratory chain complexes containing mitochondrial DNA

118 mitochondrial respiration by downregulating respiratory chain complexes I and III.

119 rkedly decreased activities of mitochondrial respiratory chain complexes I and IV with a mild decreas

120 rasomes are macromolecular assemblies of the respiratory chain complexes I, III and IV in the inner m

121 Mitochondrial respiratory chain complexes I, III, and IV can associate

122 Activities of skeletal muscle respiratory chain complexes I, III, and IV, encoded by n

123 erse functions are present in the matrix and respiratory chain complexes of mitochondria.

124 ain how AIF contributes to the biogenesis of respiratory chain complexes, and they establish an unexp

125 to downregulated expression and activity of respiratory chain complexes, features characteristic of

126 an imbalanced stoichiometry of mitochondrial respiratory chain complexes, inducing a unique combinati

127 er, and the protein content of mitochondrial respiratory chain complexes, UCP1, and PGC1alpha were at

128 h impaired activity of various mitochondrial respiratory chain complexes, were observed in muscle bio

129 viability because it encodes subunits of the respiratory chain complexes.

130 in mtDNA translate essential subunits of the respiratory chain complexes.

131 required for the normal expression of major respiratory chain complexes.

132 drial DNA code for essential subunits of the respiratory chain complexes.

133 horylation system, which is composed of four respiratory-chain complexes and adenosine triphosphate (

134 Deficiencies in respiratory-chain complexes lead to a variety of clinica

135 nuclear and mitochondrial genes that encode respiratory chain components and by NOTCH-dependent indu

136 s an opportunity to determine how individual respiratory chain components contribute to physiology fo

137 se and type-2 NADH dehydrogenase (NDH-2) are respiratory chain components predicted to be essential,

138 ately quantify the presence of mitochondrial respiratory chain components within individual bone cell

139 l genetic platform for acute inactivation of respiratory chain components.

140 are enriched in mRNAs encoding mitochondrial respiratory chain components.

141 metabolic gene expression, and mitochondrial respiratory chain content.

142 The genomic data suggest that C. trachomatis respiratory chain could produce a sodium gradient that m

143 The activity of the mitochondrial respiratory chain (cytochrome c-oxidase/succinate dehydr

144 phenformin, an inhibitor of complex I of the respiratory chain, decreased the oxygen consumption rate

145 in glucose-free galactose medium revealed a respiratory chain defect in complexes I and II, and a tr

146 c patient displayed a combined mitochondrial respiratory chain defect in cultured fibroblasts.

147 tion of mitochondrial DNA (mtDNA) damage and respiratory chain defect, metabolic disturbance, pro-apo

148 ical presentation of mitochondrial diseases, respiratory chain defects and defects of complex I speci

149 (COX)] deficiency is one of the most common respiratory chain defects in humans.

150 ependent intermediary metabolism rather than respiratory chain defects in the bioenergetic impacts of

151 n breakdown, the latter because of intrinsic respiratory chain defects.

152 DOX-induced loss of COX1-UCP3 complexes and respiratory chain defects.

153 Multiple mitochondrial respiratory-chain defects, associated with the accumulat

154 sted, revealed severe combined mitochondrial respiratory chain deficiencies associated with a marked

155 Reversible infantile respiratory chain deficiency (RIRCD) is a rare mitochond

156 howed similar pattern of mtDNA deletions and respiratory chain deficiency and (ii) to investigate the

157 e, while somatic mtDNA deletions cause focal respiratory chain deficiency associated with ageing and

158 teins in passively cleared tissues to reveal respiratory chain deficiency associated with mitochondri

159 To assess the involvement of mtDNA in respiratory chain deficiency in IPD, SN neurons, isolate

160 last population densities, and mitochondrial respiratory chain deficiency in osteoblasts and osteocla

161 disorders, leading to a mosaic mitochondrial respiratory chain deficiency in skeletal muscle.

162 The pattern of respiratory chain deficiency is similar with different g

163 en the level of mtDNA deletion and extent of respiratory chain deficiency within a single cell.

164 We performed a quantitative analysis of respiratory chain deficiency, at a single cell level, in

165 red mitochondrial function, characterized by respiratory chain deficiency, locomotor dysfunction, and

166 tochondrial genetic defect and corresponding respiratory chain deficiency.

167 se model of ageing and osteoporosis and show respiratory chain deficiency.

168 tween mtDNA deletion characteristics and the respiratory chain deficiency.

169 s group of metabolic disorders with combined respiratory-chain deficiency and a neuromuscular phenoty

170 AMFN2 is a MAM-related disorder but is not a respiratory chain-deficiency disease.

171 hput screen (HTS) was undertaken against the respiratory chain dehydrogenase component, NADH:menaquin

172 imaging reveals that contractions constitute respiratory chain-dependent episodes of depolarization c

173 one oxidoreductase), the first enzyme of the respiratory chain, display various phenotypes depending

174 in mitochondrial DNA (mtDNA) and consecutive respiratory chain dysfunction as a trigger of ROS-format

175 Respiratory chain dysfunction in IPD neurons not only in

176 ds to neurite degeneration and mitochondrial respiratory chain dysfunction in SH-SY5Y cells.

177 ide two lines of evidence that mitochondrial respiratory chain dysfunction leads to alterations in on

178 Acquired mtDNA-mutations and consecutive respiratory chain dysfunction may both trigger and perpe

179 nd skin inflammation and suggest that severe respiratory chain dysfunction, as observed in few cells

180 accumulates within mitochondria, but during respiratory chain dysfunction, high levels of reactive o

181 drial abnormalities, including mitochondrial respiratory chain dysfunction, reduced ATP synthesis and

182 AD synthase (FADS), as the cause of MADD and respiratory-chain dysfunction in nine individuals recrui

183 or succinate with different sections of the respiratory chain engaged in catalysis as a proxy for th

184 ce and restored mtDNA copy number as well as respiratory chain enzyme activities and levels.

185 ical analysis of Complex III revealed normal respiratory chain enzyme activities in the muscle of bot

186 ed myocardium, which demonstrated a combined respiratory chain enzyme deficiency.

187 ll individuals' samples, leading to combined respiratory-chain enzyme deficiency of complexes I, III,

188 xidant enzyme, activities of Krebs cycle and respiratory chain enzymes, mitochondrial morphology, and

189 is required for the insertion of heme b into respiratory chain enzymes.

190 74B cells similarly identified mitochondrial respiratory chain factors.

191 mutants and revealed that deleting genes for respiratory chain flavoproteins or for tricarboxylic aci

192 Because electrons in the respiratory chain flow from dehydrogenases' substrates t

193 lobacter jejuni uses complex cytochrome-rich respiratory chains for growth and host colonisation.

194 The mitochondrial respiratory chain, formed by five protein complexes, uti

195 ighly potent inhibitors of the mitochondrial respiratory chain from myxobacteria.

196 into host respiratory complexes, decreasing respiratory chain function and increasing oxidative stre

197 The reduced respiratory chain function in cells lacking MFN2 can be

198 thy with liver disease, including defects in respiratory chain function in patient muscle.

199 Notably, however, respiratory chain function in those cells was unimpaired

200 mitochondrial distribution or mitochondrial respiratory chain function result in corresponding chang

201 NNT)], we selectively impaired mitochondrial respiratory chain function, energy exchange, and mitocho

202 rane via affinity for cardiolipin to promote respiratory chain function.

203 ial processes, including multiple aspects of respiratory chain function.

204 ly rescued heart dysfunction, life span, and respiratory chain function.

205 regulates cristae morphology, and maintains respiratory chain function.

206 By diverting electrons away from the respiratory chain, glycolysis also enables thiol/disulfi

207 oxidases or Complex III of the mitochondrial respiratory chain, H2O2 is under sophisticated fine cont

208 itor of the mitochondrial and photosynthetic respiratory chain, has been proven to be a unique voltag

209 Second, we show that lesioning the respiratory chain impairs mitochondrial production of fo

210 xplored the structural rearrangements of the respiratory chain in human cell lines depleted of the ca

211 ficiency is the most prevalent defect in the respiratory chain in paediatric mitochondrial disease.

212 d thus target complexes of the mitochondrial respiratory chain in the inner mitochondrial membrane.

213 constitutive role in the maintenance of the respiratory chain in the nervous system, and its deficie

214 lex I is the first and the largest enzyme of respiratory chains in bacteria and mitochondria.

215 formate from serine, and that in some cells, respiratory chain inhibition leads to growth defects upo

216 neuroblastoma cells to prevent mitochondrial respiratory chain inhibitor-induced degeneration.

217 In the absence of respiratory chain inhibitors, model analysis revealed th

218 nsport of electrons along photosynthetic and respiratory chains involves a series of enzymatic reacti

219 roton-pumping complex I of the mitochondrial respiratory chain is among the largest and most complica

220 it remains unknown whether the mitochondrial respiratory chain is required for the T cell-suppression

221 structural organization of the mitochondrial respiratory chain is unknown.

222 O), the terminal enzyme of the mitochondrial respiratory chain, is a complex process facilitated by s

223 Chlororespiration, a simplified respiratory chain, is widespread across all photosynthet

224 was caused by inhibition of Complex I of the respiratory chain, leading to increases in cellular AMP

225 issues and species responsive to H2O2 as the respiratory chain, Lyn, and Syk were similarly required

226 ediates electron transfer within the aerobic respiratory chain, mitigates oxidative stress, and contr

227 nfluencing the assembly of the mitochondrial respiratory chain (MRC) complexes into supercomplexes.

228 Mitochondrial respiratory chain (MRC) enzymes associate in supercomple

229 rm the terminal segment of the mitochondrial respiratory chain (MRC).

230 embrane protein complex in the mitochondrial respiratory chain (MRC).

231 of the oxidation state of the mitochondrial respiratory chain observed in sham-treated animals.

232 xygen-dependent oxidation of the multicenter respiratory chain occurred with a single macroscopic rat

233 genase (Na(+)-NQR) is a key component of the respiratory chain of diverse prokaryotic species, includ

234 eduction of molecular oxygen to water in the respiratory chain of many human-pathogenic bacteria.

235 venging serves as a mechanism to sustain the respiratory chain of P. methylaliphatogenes when organic

236 oxs) are the basic energy transducers in the respiratory chain of the majority of aerobic organisms.

237 en acts as the terminal electron sink in the respiratory chains of aerobic organisms.

238 one oxidoreductase (NDH-2) is central to the respiratory chains of many organisms.

239 eductase (NDH-2) plays a crucial role in the respiratory chains of many organisms.

240 nctions as a redox-linked proton pump in the respiratory chains of mitochondria and bacteria, driven

241 pe cytochrome c oxidase (CcO) terminates the respiratory chains of mitochondria and many bacteria.

242 as the initial electron acceptor in aerobic respiratory chains of most organisms.

243 The respiratory chains of nearly all aerobic organisms are t

244 ium nitroprusside (complex inhibitors of the respiratory chain) on mitochondrial function were also s

245 which required increased supply of NADH for respiratory chain oxidoreductases from central carbon ca

246 cur in Enterococcus faecium, which lacks the respiratory chain pathway.

247 X), the terminal enzyme of the mitochondrial respiratory chain, plays a key role in regulating mitoch

248 n electrochemical proton gradient in aerobic respiratory chains, powering energy-requiring processes

249 p53 status, by selective degradation of its respiratory chain protein substrates and disrupts mitoch

250 gnaling pathway that regulates mitochondrial respiratory chain proteins and determines cardiomyocyte

251 found that ClpP interacts with mitochondrial respiratory chain proteins and metabolic enzymes, and kn

252 n 90), which in turn modulated mitochondrial respiratory chain proteins and their metabolic output.

253 stages of prion infection, dysregulation of respiratory chain proteins may lead to impairment of mit

254 cardiolipin and functions in the assembly of respiratory chain proteins.

255 n contain a high proportion of mitochondrial respiratory chain proteins.

256 naerobic glycolysis and not on mitochondrial respiratory chain (RC) activity.

257 lactic acidemia in association with combined respiratory chain (RC) deficiencies of complexes I, III

258 Mitochondrial respiratory chain (RC) disease therapies directed at int

259 ce oxidative stress in primary mitochondrial respiratory chain (RC) disease, improving cellular viabi

260 ular and tissue changes, including decreased respiratory chain (RC) function, increased reactive oxyg

261 han 100 metabolites across various states of respiratory chain (RC) function.

262 The mitochondrial respiratory chain (RC) produces most of the cellular ATP

263 Defects in the mitochondrial respiratory chain (RC) underlie a spectrum of human cond

264 mitochondria assemble four complexes of the respiratory chain (RCI, RCIII, RCIV, and RCV) by combini

265 nction was ameliorated and the mitochondrial respiratory chain recovered following obeticholic acid t

266 vely, our data lend mechanistic insight into respiratory chain-related activities and prioritize hund

267 t rather might be achieved by Q8-independent respiratory chain remodeling.

268 Assembly of the mitochondrial respiratory chain requires the coordinated synthesis of

269 ng several key proteins in the mitochondrial respiratory chain (rho(0) cells), the membrane potential

270 ogenesis, along with increased expression of respiratory chain subunits and normal oxygen consumption

271 c translational activators ensure that these respiratory chain subunits are synthesized at the correc

272 regulates the expression of nuclear-encoded respiratory chain subunits involved in Complexes I, II,

273 technique enabling the quantification of key respiratory chain subunits of complexes I and IV, togeth

274 Interaction of Coi1 with respiratory chain subunits seems transient, as it appear

275 analysis confirmed the reduced levels of the respiratory chain subunits that included mitochondrially

276 lear (succinate dehydrogenase A) DNA-encoded respiratory chain subunits.

277 translation and decreased levels of multiple respiratory chain subunits.

278 but do not preserve mitochondrial cristae or respiratory chain supercomplex assembly in prohibitin-de

279 In the yeast Saccharomyces cerevisiae, respiratory chain supercomplexes form by association of

280 into large macromolecular structures, termed respiratory chain supercomplexes or respirasomes.

281 l facilitates the formation of mitochondrial respiratory chain supercomplexes to sustain high mitocho

282 iate with monomeric cytochrome c oxidase and respiratory chain supercomplexes.

283 O), the terminal enzyme in the mitochondrial respiratory chain that catalyzes the reduction of oxygen

284 cing of ND75, a subunit of the mitochondrial respiratory chain that controls ROS formation independen

285 s as an initial electron acceptor in aerobic respiratory chains that reduces quinone and pumps proton

286 heir essential role in the biogenesis of the respiratory chain, the molecular function of twin Cx9C p

287 rmembrane space, delivering electrons to the respiratory chain through CYTc These results provide a c

288 a signal transduction pathway that links the respiratory chain to the mitochondrial intermembrane spa

289 esentative PRC-dependent stress genes by the respiratory chain uncoupler, carbonyl cyanide m-chloroph

290 ponse as the results place the mitochondrial respiratory chain upstream of tyrosine-protein kinase Ly

291 omplexes and their homologues from bacterial respiratory chains using O(2) as a terminal acceptor, th

292 nts from cytosolic NADH to the mitochondrial respiratory chain via the D-lactate dehydrogenase Dld1.

293 and Hhy are obligately linked to the aerobic respiratory chain via the menaquinone pool and are diffe

294 rthermore, by compromising components of the respiratory chain, we demonstrated that the reliance on

295 processes such as photosynthesis and in the respiratory chain, where they mediate long-range charge

296 s succinate:quinone reductase as part of its respiratory chain, whereas under microaerophilic conditi

297 and DMK function predominantly in anaerobic respiratory chains, whereas UQ is the major electron car

298 oduction of reactive oxygen species from the respiratory chain, which prevents L-form growth.

299 ve stress in bacteria through a block in the respiratory chain, which results in decreased respiratio

300 It is the largest protein assembly of the respiratory chain with a total mass of 970 kilodaltons.