ライフサイエンスコーパス: respiratory epithelium

1 ganelle, that mediates adherence to the host respiratory epithelium.

2 mily and mediates bacterial adherence to the respiratory epithelium.

3 latter is detected in histologically normal respiratory epithelium.

4 procal signaling from the vasculature to the respiratory epithelium.

5 vely expressed in stem cells of the adjacent respiratory epithelium.

6 it from neuroendocrine catecholamines on the respiratory epithelium.

7 amily and mediates bacterial adhesion to the respiratory epithelium.

8 of the virus to interact with and cross the respiratory epithelium.

9 rentiation of early tracheal epithelium into respiratory epithelium.

10 ma, haemorrhage and rapid destruction of the respiratory epithelium.

11 normal tissue to the reproductive tracts and respiratory epithelium.

12 some morphological features consistent with respiratory epithelium.

13 igration of B. cenocepacia through polarized respiratory epithelium.

14 e also discovered that Reg3g is a marker for respiratory epithelium.

15 substantially replicated in eosinophils and respiratory epithelium.

16 ed olfactory epithelium and to the adjoining respiratory epithelium.

17 esenting the nasal ciliated pseudostratified respiratory epithelium.

18 f plunc was up-regulated after bulbectomy in respiratory epithelium.

19 receptor, which is expressed by cells in the respiratory epithelium.

20 ncing delivery of tobacco carcinogens to the respiratory epithelium.

21 rocess that probably depends on adherence to respiratory epithelium.

22 highly localized to the microvilli layer of respiratory epithelium.

23 ion, resulting in increased infection of the respiratory epithelium.

24 vaccine to mucosal inductive tissues and the respiratory epithelium.

25 mediate attachment of Bordetella species to respiratory epithelium.

26 d to alveolar Type II and Clara cells in the respiratory epithelium.

27 preferentially infect ferret and human nasal respiratory epithelium.

28 oximal bronchiolar epithelium and the distal respiratory epithelium.

29 n exclusive human pathogen which infects the respiratory epithelium.

30 ung tumor cell line representative of distal respiratory epithelium.

31 or cell line (H441) representative of distal respiratory epithelium.

32 and promote its internalization into the WD respiratory epithelium.

33 IAV replication are epithelial cells in the respiratory epithelium.

34 CsA were able to prevent the loss of normal respiratory epithelium.

35 Importantly, LFM also prevented the loss of respiratory epithelium.

36 al tissue showed minimal binding to ciliated respiratory epithelium.

37 nfluenza virus infection of MHC class II -/- respiratory epithelium.

38 the transcription of genes expressed in the respiratory epithelium.

39 initiates infection by colonizing the upper respiratory epithelium.

40 ages, neutrophils, vascular endothelium, and respiratory epithelium.

41 rsally located cells in olfactory sensory or respiratory epithelium.

42 in chemoattraction of lymphocytes toward the respiratory epithelium.

43 differentiate to reconstitute the functional respiratory epithelium.

44 um and thirteen distinct cell types from the respiratory epithelium.

45 uded without disrupting the integrity of the respiratory epithelium.

46 preserved ciliated pseudostratified columnar respiratory epithelium.

47 ling and cell shedding in homeostasis of the respiratory epithelium.

48 epithelial cation and anion transport in the respiratory epithelium.

49 rapid spread of the virus through the upper respiratory epithelium.

50 lated eosinophils, and 10 were replicated in respiratory epithelium.

51 pt expression in testis compared to ciliated respiratory epithelium.

52 th the first line of our airway defense, the respiratory epithelium.

53 chemo-attraction of lymphocytes towards the respiratory epithelium.

54 teins and is expressed in nasopharyngeal and respiratory epithelium.

55 thelium is not a good surrogate for the lung respiratory epithelium.

56 iates infection by colonizing the genital or respiratory epithelium.

57 TLR-dependent inflammatory responses of the respiratory epithelium.

58 tiate infection by colonizing the genital or respiratory epithelium.

59 hil chemoattractant that is mobilized in the respiratory epithelium after allergic stimulation.

60 show that RB is essential for repair of the respiratory epithelium after cytotoxic damage and suppor

61 ne gammaherpesvirus MHV-68 multiplies in the respiratory epithelium after intranasal inoculation, the

62 ting a basolaterally located receptor in the respiratory epithelium, alphaherpesviruses have generate

63 nked glycoprotein that mediates adherence to respiratory epithelium, an essential early step in the p

64 ng sacculation, induced proliferation in the respiratory epithelium and accelerated lung tumor growth

65 otility are required for colonization of the respiratory epithelium and are mediated largely by a dif

66 proteins that promote bacterial adherence to respiratory epithelium and are the predominant targets o

67 Viral antigens were localized to ciliated respiratory epithelium and cells of submucosal glands an

68 quine herpesvirus 1 (EHV1) replicates in the respiratory epithelium and disseminates through the body

69 they form cysts that express several TSA of respiratory epithelium and exhibit some morphological fe

70 we specifically express B3GAT1 in the murine respiratory epithelium and find that overexpression is n

71 ic-oxide synthases (NOS) are abundant in the respiratory epithelium and generate the NO radical, whic

72 and MUC16) genes, which are exclusive to the respiratory epithelium and goblet cells of bronchial str

73 S. pneumoniae that colonized the respiratory epithelium and grew in the bloodstream were

74 concomitant with NF-kappaB activation in the respiratory epithelium and initiation of the inflammator

75 trate that T2R38 is expressed in human upper respiratory epithelium and is activated in response to a

76 syncytial virus (RSV) preferentially infects respiratory epithelium and is an important cause of lowe

77 nor trachea repopulated with the recipient's respiratory epithelium and mesenchymal stromal cells.

78 velopment, including dilated airspaces, thin respiratory epithelium and mesenchyme, and elastin fiber

79 rmo1-Cre mice to delete Wls in the embryonic respiratory epithelium and mesenchyme, respectively.

80 mechanism by which this organism adheres to respiratory epithelium and seeds joints and bones.

81 anted airways remodeled with a flattening of respiratory epithelium and significant subepithelial fib

82 rt a role for CFTR in differentiation of the respiratory epithelium and suggest that its expression l

83 the morphology and level of chimerism of the respiratory epithelium and the degree of airway remodeli

84 gly inhibited in several tissues such as the respiratory epithelium and the fallopian tube.

85 olarity of alphaherpesvirus infection in the respiratory epithelium and the role of respiratory epith

86 dependent on reciprocal interactions between respiratory epithelium and the underlying vasculature, e

87 scle actin (alphaSMA) expression in vessels, respiratory epithelium, and interstitium of phosphatase-

88 tial relationship between mast cells and the respiratory epithelium, and the importance of tightly re

89 read occurring via the apical surface of the respiratory epithelium, and underscore delivery of neutr

90 Thus, ATP and purinergic signaling in the respiratory epithelium are critical sensors for airway e

91 ar injury and failure to properly repair the respiratory epithelium are intrinsic to IPF pathogenesis

92 Lactobacilli, when targeted to the respiratory epithelium, are highly effective at suppress

93 d particles with essential properties of the respiratory epithelium as a barrier as well as affecting

94 ransition in nasal tropism from olfactory to respiratory epithelium as the virus evolved.

95 n embryonic neural tube, spinal ganglia, and respiratory epithelium, as well as in developing cartila

96 ls derived from human vaginal, cervical, and respiratory epithelium, as well as increasing adherence

97 LFM groups, respectively; the percentage of respiratory epithelium at 14 days was 0%, 21%, and 95%.

98 RPM groups, respectively; the percentage of respiratory epithelium at 21 days was 0%, 39%, 86%, and

99 ted the innate immune response to IAV in the respiratory epithelium at the single-cell level, providi

100 productive phase of MHV-68 infection in the respiratory epithelium but are maintained at relatively

101 al with widespread dysplastic changes in the respiratory epithelium but no overt carcinoma.

102 syncytial virus (RSV) primarily infects the respiratory epithelium, but growing evidence suggests th

103 nal expansion, and reconstitution of injured respiratory epithelium by fusion-independent mechanisms.

104 gest that B. cenocepacia traverses polarized respiratory epithelium by the dephosphorylation and diss

105 It specializes in infection of the ciliated respiratory epithelium, causing disease of variable seve

106 protein affected the olfactory, but not the respiratory, epithelium, causing severe reduction of the

107 n across in vitro model systems of polarized respiratory epithelium consisting of 16HBEo cells transf

108 The respiratory epithelium consists of lung sentinel cells,

109 Resident alveolar macrophages and respiratory epithelium constitutes the first line of def

110 y, H7N9 viruses showed a greater tropism for respiratory epithelium covering nasal passages and nasop

111 Mycoplasma adherence to the respiratory epithelium (cytadherence) is required for co

112 Genetic deletion of Foxm1 from mouse respiratory epithelium during initial stages of lung dev

113 tudy, Foxm1 was deleted conditionally in the respiratory epithelium (epFoxm1(-/-)).

114 n that enzymatically removes sialic acids on respiratory epithelium, exhibits potent antiviral activi

115 Human respiratory epithelium expresses inducible nitric oxide

116 ung alveolar regions (site of infection) and respiratory epithelium for controls.

117 ors are effective to specifically target the respiratory epithelium for either corrective gene therap

118 The respiratory epithelium forms the first line of defense a

119 consequence of the change in function of the respiratory epithelium from chloride secretion to sodium

120 normal baseline data for nasal transitional/respiratory epithelium from healthy rats.

121 generation of mature multiciliated cells in respiratory epithelium from iPSCs is a significant advan

122 anelle which functions in adherence to human respiratory epithelium, gliding motility, and cell divis

123 Respiratory epithelium has been increasingly recognized

124 (AdV)-mediated gene transfer to the ciliated respiratory epithelium has hindered gene transfer strate

125 and precisely how M. pneumoniae injures the respiratory epithelium has remained a mystery for >50 ye

126 The TLRs are important components of the respiratory epithelium host innate defense, enabling the

127 al to the tumors were detected in the normal respiratory epithelium in 9 of 21 (43%) patients with EG

128 e investigated by using differentiated human respiratory epithelium in air-liquid interface cultures.

129 s organism also commonly colonizes the upper respiratory epithelium in an asymptomatic fashion.

130 nspecific injury models, we investigated the respiratory epithelium in an immune-specific orthotopic

131 through inhalation, although the role of the respiratory epithelium in disease pathogenesis has not b

132 dectin-1 is constitutively expressed by the respiratory epithelium in humans and that IL-33 specific

133 is limited to the superficial layers of the respiratory epithelium in immunocompetent individuals.

134 lays a crucial role in the maturation of the respiratory epithelium in late gestation, being required

135 ill be useful to interrogate the role of the respiratory epithelium in multiple lung diseases.

136 Given the proposed role of respiratory epithelium in nonspecific injury models, we

137 is not clear how the virus can traverse the respiratory epithelium in order to initiate infection in

138 on in the upper respiratory tract, the nasal respiratory epithelium in particular, of donors is a dri

139 LLT1 expression by the respiratory epithelium in response to respiratory-virus

140 Respiratory epithelium in the conducting airways of the

141 ms responsible for the spread of MV into the respiratory epithelium in the late stages of the disease

142 The involvement of the respiratory epithelium in the mechanisms of CRS is poorl

143 This study highlights the role of the respiratory epithelium in the trafficking of T lymphocyt

144 bit NTHi colonization and infection of human respiratory epithelium in vitro We have now assessed whe

145 ied to a perfused preparation of human nasal respiratory epithelium in vitro.

146 GATA-6 is co-expressed with TTF-1 in the respiratory epithelium in vivo and respiratory epithelia

147 delivery paralleled hpIgR expression in the respiratory epithelium in vivo and was not increased by

148 rly seen in the liver, intestine, thymus and respiratory epithelium including nasopharynx, trachea an

149 iption of genes expressed selectively in the respiratory epithelium including pulmonary surfactant A,

150 ously shown that cytokine stimulation of the respiratory epithelium induces a precipitous decline in

151 MeV infection of the respiratory epithelium induces shedding of multinucleate

152 ly shown that S. pneumoniae infection of the respiratory epithelium induces the production of the 12-

153 was greatly enhanced upon destruction of the respiratory epithelium integrity with EGTA or N-acetylcy

154 How microorganisms, immunity and the respiratory epithelium interact to contribute to lung in

155 Adherence to respiratory epithelium is an important step in the proce

156 Maintaining the integrity of the respiratory epithelium is critical for an effective host

157 r findings demonstrate that integrity of the respiratory epithelium is crucial in the host's innate d

158 The human respiratory epithelium is derived from a progenitor cell

159 The cellular composition of the murine respiratory epithelium is established during development

160 RGS4 expression in respiratory epithelium is increased in subjects with sev

161 antiproliferative activity of P. carinii on respiratory epithelium is mediated in part through modul

162 Expression of MK in the respiratory epithelium is regulated by hypoxia and HIF-1

163 Mycoplasma attachment to the host respiratory epithelium is required for colonization and

164 If mucociliary clearance in the respiratory epithelium is severely impaired, the disorde

165 The respiratory epithelium is subject to continuous environm

166 expression of activated Kras(G12D) in mouse respiratory epithelium is sufficient to induce lung aden

167 Oncogenic K-Ras expression in the respiratory epithelium is sufficient to initiate NSCLC t

168 ds on intercellular adhesion, whilst damaged respiratory epithelium is the primary instigator of airw

169 Respiratory epithelium is the target of therapies, such

170 nistration of HDM in mice lacking CAR in the respiratory epithelium leads to loss of peri-bronchial i

171 pha deletion, that loss of C/EBPalpha in the respiratory epithelium leads to respiratory failure at b

172 y, perinatal overexpression of VEGF-C in the respiratory epithelium led to a condition resembling hum

173 features of human airway rejection (loss of respiratory epithelium, luminal granulation tissue, lymp

174 the progression of MV infection through the respiratory epithelium may involve pathways other than d

175 ata suggest that hantavirus infection of the respiratory epithelium may play an important role in the

176 Under conditions of airway inflammation, the respiratory epithelium may serve an important role in th

177 on of influenza A virus replication to mouse respiratory epithelium means that this host response is

178 which subsequently reconstitute as aneuronal respiratory epithelium (metaplasia).

179 interactions of influenza A virus (IAV) with respiratory epithelium might determine the outcome of in

180 Within the respiratory epithelium, more than one cell type expresse

181 ENV, SARS and MERS CoVs predominantly infect respiratory epithelium, not macrophages.

182 Expression of Spdef in the respiratory epithelium of adult transgenic mice caused g

183 tors have been used for gene transfer to the respiratory epithelium of experimental animals and indiv

184 Expression of GM-CSF in the respiratory epithelium of GM-/- mice improved bacterial

185 the synthesis of GM-CSF was directed to the respiratory epithelium of GM-CSF-hull mutant mice (GM-/-

186 The respiratory epithelium of humans and animals is frequent

187 r the human thrombopoietin (TPO) cDNA-to the respiratory epithelium of immunocompetent Balb/c mice.

188 methylation of the p16 and MGMT genes in the respiratory epithelium of individuals at high risk for l

189 d inflammatory immune cells infiltrating the respiratory epithelium of mice exposed to OVA or HDM.

190 cells were found in lymphoepithelium and not respiratory epithelium of nasopharyngeal tonsils or aden

191 9, a novel coronavirus was isolated from the respiratory epithelium of patients with unexplained pneu

192 ed in the histologically normal and abnormal respiratory epithelium of smokers.

193 f expression of the GRP receptor mRNA in the respiratory epithelium of some individuals with a histor

194 vine conglutinin (Cong) was expressed in the respiratory epithelium of SP-D gene-targeted (SP-D(-/-))

195 which SP-D was conditionally replaced in the respiratory epithelium of SP-D(-/-) mice.

196 alcineurin b1 (Cnb1) gene was deleted in the respiratory epithelium of the fetal mouse.

197 of a bioactive Fc-fusion protein across the respiratory epithelium of the mouse in vivo.

198 , the RB gene was selectively deleted in the respiratory epithelium of the mouse.

199 consistently, the viruses caused necrosis in respiratory epithelium of the nasal cavity, trachea, bro

200 AAV-CFTR was administered to the respiratory epithelium of the nose or lung of rhesus mac

201 CAS was also concentrated in the respiratory epithelium of the trachea and in axons and P

202 Expression of TGF-beta 1 in the developing respiratory epithelium of transgenic mice arrested lung

203 e mutated protein was targeted to the distal respiratory epithelium of transgenic mice.

204 Targeted expression of LysM(D53S) in the respiratory epithelium of wild-type (LysM(+/+)/LysM(D53S

205 te smaller sample sizes, in studies of nasal respiratory epithelium or eosinophils.

206 Haemophilus influenzae (NTHi) adheres to the respiratory epithelium or, in the case of epithelial dam

207 lective deletion of the Hgf receptor gene in respiratory epithelium phenocopies the malformation of s

208 The respiratory epithelium plays a central role in innate im

209 y proinflammatory cytokines in the asthmatic respiratory epithelium plays a central role in the obser

210 The respiratory epithelium plays a central role in the regul

211 Adhesion to the respiratory epithelium plays an important role in Haemop

212 how that Foxa2, expressed selectively in the respiratory epithelium, plays a critical role in regulat

213 deletion of Foxm1 from Kras(G12D)-expressing respiratory epithelium prevented the initiation of lung

214 Mycoplasma pneumoniae adsorbs to host respiratory epithelium primarily by its attachment organ

215 The respiratory epithelium provides a physical, functional,

216 both normal and abnormal nasal olfactory and respiratory epithelium, pulmonary alveolar macrophages,

217 inguish NALT M cells from other cells of the respiratory epithelium (RE), we performed lectin histoch

218 ies than more anterior regions closer to the respiratory epithelium (Regions 3 and 4).

219 In response to infections and irritants, the respiratory epithelium releases the alarmin interleukin

220 but the processes favoring its spread in the respiratory epithelium remain poorly defined.

221 ily targets and how infection influences the respiratory epithelium remains incompletely understood.

222 Colonization of the respiratory epithelium requires proper assembly of a com

223 These data provide a model wherein the respiratory epithelium responds to hypoxia via HIF-1alph

224 Main Results: Loss of functional p73 in the respiratory epithelium resulted in a near-complete absen

225 Selective inactivation of the Vegf-A gene in respiratory epithelium results in an almost complete abs

226 lpha-mediated activation of NF-kappaB in the respiratory epithelium similarly induces p65 denitrosyla

227 Dox administration induced marked respiratory epithelium-specific FasL mRNA and protein up

228 bsp. hominissuis to bind and invade the host respiratory epithelium, suggesting new potential targets

229 receptors, which are characteristic of human respiratory epithelium, than for Neu5Ac(alpha2-3)Gal-con

230 nza viral infections result in damage to the respiratory epithelium that facilitates secondary infect

231 ll as those regulating the maturation of the respiratory epithelium that is required for lung functio

232 el mechanism for field carcinogenesis in the respiratory epithelium that may be of importance in asse

233 nt to mediate the metaplastic changes in the respiratory epithelium that occur in pathological condit

234 ation and morphogenesis were observed in the respiratory epithelium, the bronchiolar smooth muscle, a

235 ellular adhesion molecule-1 (ICAM-1), by the respiratory epithelium, the hypothesis has been proposed

236 on respiratory virus, is known to infect the respiratory epithelium, the mechanism of infection and t

237 ion cleared the virus from Fas+/+ and Fas-/- respiratory epithelium, the P-/- effectors were operatio

238 Adhesion of NTHI to the respiratory epithelium, therefore, upregulates the expre

239 ent, including undilated airspaces, cuboidal respiratory epithelium, thickened mesenchyme, and lack o

240 ce of M. hyopneumoniae to the cilia of swine respiratory epithelium through an interaction involving

241 contribution of cellular composition of the respiratory epithelium to infection and pathology are st

242 s used to study the susceptibility of the CF respiratory epithelium to P. aeruginosa strain PAK and t

243 iginating from periodontal tissues may alter respiratory epithelium to promote infection by respirato

244 Transfer from the respiratory epithelium to regional lymph nodes appears t

245 To further explore the reaction of the respiratory epithelium to the fungus, we analyzed the pr

246 mimicking the microenvironment of the human respiratory epithelium, to study the production and regu

247 ESC-derived Nkx2.1+ progenitor cells formed respiratory epithelium (tracheospheres) when transplante

248 Expressed by the embryonic respiratory epithelium, VEGF-A signals endothelial cells

249 the inaccessible CF airways by targeting the respiratory epithelium via the human polymeric immunoglo

250 to inaccessible CF airways by targeting the respiratory epithelium via the polymeric immunoglobulin

251 ation studies demonstrated that the infected respiratory epithelium was a major source of IFN-alpha/b

252 plunc up-regulation in respiratory epithelium was confirmed by Northern blot an

253 tive pulmonary disease (COPD) human ciliated respiratory epithelium was determined.

254 spared from Omicron infection at 2 dpi, the respiratory epithelium was strongly infected with increa

255 16), primarily secreted by club cells in the respiratory epithelium, was highly upregulated following

256 ide anion, a potent mediator that can damage respiratory epithelium, was markedly increased after 2-2

257 ecause adenovirus is adept in binding to the respiratory epithelium, we tested the adenovirus 2 fiber

258 n tracheal graft narrowing and protection of respiratory epithelium were as follows: After 14 days of

259 bs showed that certain leukocytes as well as respiratory epithelium were intensely immunoreactive, an

260 determine the chemokine response pattern of respiratory epithelium when infected with respiratory sy

261 sease-specific human lung progenitors formed respiratory epithelium when subcutaneously engrafted int

262 though isografts appeared patent with normal respiratory epithelium when they were removed.

263 HMW) adhesins that mediate attachment to the respiratory epithelium where they interact with the host

264 y synthesized in subsets of cells lining the respiratory epithelium, where its expression is regulate

265 lung cell types except for smooth muscle and respiratory epithelium, which have a IV-2 and a IV-1 pre

266 e disease begins with bacterial adherence to respiratory epithelium, which is dependent on type IV pi

267 elf-renewal and differentiation of the upper respiratory epithelium, which is key for adaptation to n

268 heterogeneity are reciprocally expressed by respiratory epithelium, which raises interesting questio

269 This is the first protein found in respiratory epithelium whose expression is regulated by

270 These results suggest that infection of the respiratory epithelium with rhinovirus can antagonize to

271 Ps were not readily taken up into or through respiratory epithelium, with very low silver levels foun

272 the contagion measles virus (MV) crosses the respiratory epithelium within myeloid cells that express

273 , specifically to the lumenal surface of the respiratory epithelium, within the airway surface fluid,