ライフサイエンスコーパス: response regulator

1 pe systems that employ a sensor kinase and a response regulator.

2 sensor histidine kinase (HK) and an effector response regulator.

3 y named the protein RsrR for Redox sensitive response Regulator.

4 y, thereby regulating the levels of the CheY response regulator.

5 f XBP1u mRNA to spliced XBP1 (XBP1s), an UPR response regulator.

6 rgfA results in premature truncation of the response regulator.

7 d NreC has been characterized as its cognate response regulator.

8 and phosphatase activities over an effector response regulator.

9 The JmjC protein Mina is an important immune response regulator.

10 n indicates a role in repression by the SalR response regulator.

11 transfers its phosphoryl group to a cognate response regulator.

12 er from its sensor kinase domain to the AtsT response regulator.

13 lead to phosphorylation of the cognate BumR response regulator.

14 and ABA is thought to serve as a key stress-response regulator.

15 A is a sensor kinase/phosphatase for CpxR, a response regulator.

16 ne pentaphosphate (ppGpp) alarmone/stringent response regulator.

17 one of the most abundantly expressed type-B Response Regulators.

18 se activity and mutants involving the type B response regulators.

19 s a knotless red/far-red phytochrome and two response regulators.

20 to an uncharacterized family of DNA-binding response regulators.

21 lects the transcriptional activity of type-B response regulators.

22 ation and phosphotransfer from HnoK to three response regulators.

23 s the functional capabilities of DNA-binding response regulators.

24 se to cytokinin being mediated by the type-B response regulators.

25 the core genome, some of which encode orphan response regulators.

26 s and similar mechanisms of action for these response regulators.

27 to both EXPA promoter fragments and DELLA GA-response regulators.

28 hus constitute a general strategy for tuning response regulators.

29 ctive state of receiver domains of bacterial response regulators.

30 esis, transport/binding, and transcriptional/response regulators.

31 rv0431 be named "vesiculogenesis and immune response regulator."

32 he TZ [9, 10]. Cytokinin via the ARABIDOPSIS RESPONSE REGULATOR 1 (ARR1) control auxin distribution w

33 copper-sensing transcription factor, copper response regulator 1 (CRR1), dramatically reduces the co

34 n of a CML-interacting partner, PRR2 (PSEUDO-RESPONSE REGULATOR 2), a plant specific transcription fa

35 GLK2 and the related gene ARABIDOPSIS PSEUDO RESPONSE REGULATOR 2-LIKE (SlAPRR2-LIKE) to establish th

36 the interactome of SPY, we identified PSEUDO-RESPONSE REGULATOR 5 (PRR5), one of the core circadian c

37 ows partial identity to maize gene BT068773 (RESPONSE REGULATOR 6).

38 repressor that binds the promoter of Pseudo Response Regulator 7 (PRR7) at a conserved binding site.

39 Here, we show that PSEUDO-RESPONSE REGULATOR 7 (PRR7), a central component of the

40 Finally, we identified the cognate response regulator (A1S_0236) for GacS and confirmed the

41 picture of how histidine kinases and cognate response regulators achieve required efficiency, specifi

42 DELLA proteins, negative GA response regulators, act as positive factors for ovule i

43 Type-B response regulators, acting as transcriptional activator

44 We have previously showed that the RcsB response regulator activates expression of the cupD gene

45 The ResD response regulator activates transcription of diverse ge

46 The dominant theory on the mechanism of response regulators activation in two-component bacteria

47 between the sabA promoter region and ArsR, a response regulator affecting sabA expression.

48 ptide to activate its own expression via the response regulator AgrA as well as the expression of a r

49 interact with the DNA-binding domain of the response regulator AgrA from S. aureus.

50 of AIP via the histidine kinase AgrC and the response regulator AgrA.

51 expression of one CK receptor (AHK4) and one response regulator (AHP6).

52 losis genes Rv0844c/Rv0845 encoding the NarL response regulator and NarS histidine kinase are hypothe

53 relevance to NO metabolism and that the ResD response regulator and NsrR coordinately regulate transc

54 or two-component system mutants, the cognate response regulator and sensor kinase genes clustered tig

55 RssB is an atypical response regulator and the only known ClpXP adaptor that

56 e questions, we studied the Escherichia coli response regulator and transcription factor RcsB, which

57 rate that RpoE is a key cell envelope stress response regulator and, similar to E. coli, RpoE may hav

58 l features that enable function of canonical response regulators and a basis for distinguishing nonca

59 nges in the DNA arising from the presence of response regulators and coinducer molecules binding to C

60 via several experimental approaches that the response regulators and coinducers act synergistically o

61 cidating crystal structures of fungal stress response regulators and emphasizes how this knowledge ca

62 of using DNA binding domains from bacterial response regulators and their cognate binding elements i

63 harboring the domains of sensor kinases and response regulators, and thus, are thought to autophosph

64 n Arabidopsis (Arabidopsis thaliana), type-B response regulators (ARABIDOPSIS RESPONSE REGULATORS [AR

65 es are shown to also activate the nonrelated response regulators ArcA, CpxR, RcsB, and PhoQ.

66 We found that only three response regulators, ArcA, CpxR, and RcsB, produce stron

67 ion and was dependent on either the nitrogen response regulators AreA and AtfA or the iron response r

68 lade of the CK-responsive type-A Arabidopsis response regulator (ARR) genes increases in buds followi

69 characterized the growth-promoting cytokinin response regulator ARR1, and the wood development genes

70 network initiated by the type-B ARABIDOPSIS RESPONSE REGULATORs (ARRs) that mediate the cytokinin pr

71 is regulated by action of type-B Arabidopsis response regulators (ARRs).

72 tionally antagonistic classes of Arabidopsis response regulators (ARRs): type B ARRs (response activa

73 na), type-B response regulators (ARABIDOPSIS RESPONSE REGULATORS [ARRs]) form three subfamilies based

74 Previous studies indicated that the response regulators, as well as various coinducers (effe

75 GATA4 activation depends on the DNA damage response regulators ATM and ATR, but not on p53 or p16(I

76 in AtsR, and we also identify the cytosolic response regulator AtsT (BCAM0381) as a key component of

77 e, comprehensive kinetic characterization of response regulator autophosphorylation is limited to Che

78 egulatory activity of its cognate downstream response regulator, BfmR.

79 The unfolded protein response regulator binding immunoglobulin protein/78-kDa

80 ication was completely dependent on the OmpR response regulator, but did not require known OmpR-regul

81 proprietary ligand Phos-tag to separate the response regulator BvgA from its phosphorylated counterp

82 and transferring the phosphoryl group to the response regulator BvgA.

83 em regulates this CM remodeling via the LiaR response regulator by a previously unknown mechanism.

84 ss of QseC causes overactivation of the QseB response regulator by PmrB cross-phosphorylation.

85 regulation of ompA and report that the MisR response regulator can bind upstream of the ompA transla

86 controlled by the phosphorylated form of the response regulator CheY (CheY-P).

87 An activated form of the response regulator CheY destabilizes the parallel arrang

88 The response regulator CheY increased motor switching from c

89 the gain of the pathway at the level of the response regulator CheY increases with overall chemotaxi

90 Binding of the chemotaxis response regulator CheY-P promotes switching between rot

91 ns to phosphorylate the flagellar rotational response regulator, CheY, and modulate the flagellar rot

92 in the steady-state level of the chemotaxis response regulator, CheY-P, by adjusting the number of F

93 stensibly, the output of Che2 occurs via its response regulator CheY2, but controversy persists over

94 ster histidine kinase, CheA4, or the central response regulator, CheY7, also showed transient pauses.

95 c, a process controlled by the two-component response regulator CiaR and requiring Sia uptake by the

96 on the protein level, we found that the PmrA response regulator contributes to qseB transcription in

97 sis factors, including chaperones and stress-response regulators, controlled the response to carfilzo

98 The response regulator CpdR couples phosphorylation events i

99 The response regulator CpxR appears to function as a positiv

100 ls of CpxA, which activates virF through the response regulator CpxR.

101 rothelial cells, and we demonstrate that the response regulator (CpxR)-sensor kinase (CpxA) two-compo

102 activation and deactivation of the essential response regulator CtrA.

103 the degradation of an essential DNA-binding response regulator, CtrA, by the ClpXP protease.

104 hia coli, membrane-bound sensor CusS and its response regulator CusR together regulate the transcript

105 Deletion of the cpxR transcriptional response regulator derepresses hlyA expression, leading

106 In contrast, deletion of the rpoS stress response regulator did not affect in vivo survival.

107 Our data challenge the notion that response regulator dimers primarily form between two pho

108 on or in the presence of bacterial stringent response regulators DksA and ppGpp.

109 that, in addition to function as a stringent response regulator, DksA promotes the transcription and/

110 and likely other plants that display common response regulator DNA-binding specificities.

111 The molecular basis for formation of stable response regulator-DNA complexes that precede the assemb

112 Our results show that the response regulator domain of FrzE is a negative regulato

113 This indicates that the response regulator domain of FrzE is required for the in

114 lation of FrzZ; this inhibition required the response regulator domain of FrzE.

115 ted an intramolecular phosphotransfer to the response regulator domain that resulted in c-di-GMP degr

116 domain, followed by an autokinase domain, a response regulator domain, and a C-terminal c-di-GMP pho

117 by phosphotransfer to an Asp residue of the response regulator DosR.

118 me receptors or activate overlapping sets of response regulators downstream.

119 ested by a histidine kinase (receptor) and a response regulator (effector).

120 carboxypeptidase encoded by pbpX, the orphan response regulator encoded by degU, and the highly abund

121 nsional protein structures predicted for the response regulators encoded by cop and czc operons showe

122 ssion between the two strains, a GntR-family response regulator encoding gene (LMOf2365_0414), design

123 hemical data have defined the mechanisms for response regulator enzymatic activities, revealed trends

124 ylation kinetics of 21 variants of the model response regulator Escherichia coli CheY that contained

125 a dual-hairpin substrate for the RNA binding-response regulator, EutV.

126 bers of the TIMING OF CAB1 EXPRESSION/PSEUDO RESPONSE REGULATOR family of core-clock genes in the aft

127 tivation of proteins belonging to the type-B Response Regulator family of cytokinin response activato

128 by the adaptor protein RssB, a member of the response regulator family.

129 consisting of the sensor kinase FlgS and the response regulator FlgR.

130 and we demonstrate that AlgB is the partner response regulator for BphP in diverse bacterial phyla.

131 rithm's performance on histidine kinases and response regulators from bacterial two-component signali

132 fimZ is homologous to response regulators from other two-component regulatory

133 ously, we showed that phosphorylation of the response regulator FrzZ correlates with reversal frequen

134 phosphotransfer from the kinase FrzE to the response regulator FrzZ is required, it is unknown how p

135 summarizes structural features that underlie response regulator function.

136 Response regulators function as the output components of

137 est that CheY2, despite resembling a typical response regulator, functions distinctively from most ot

138 izes a complex between 14-3-3 and the stress response regulator GCN1, inducing GCN1 turnover and neur

139 By contrast, only the duplicated response regulator gene is present in the sex-linked reg

140 the activity of a divergent histidine kinase-response regulator gene pair.

141 ock function in Arabidopsis thaliana: PSEUDO-RESPONSE REGULATORs, GIGANTEA, and the evening complex g

142 esponse regulators AreA and AtfA or the iron response regulator HapX.

143 Phosphorylation, and thereby activation, of response regulators has been demonstrated to occur by th

144 ctivation and new roles for unphosphorylated response regulators have been identified.

145 , PGC-1alpha requires the central heat shock response regulator heat shock factor protein 1 (HSF1) to

146 ated monomers and raise the possibility that response regulator heterodimers containing one phosphory

147 Without conserved global stress response regulators, how the obligate intracellular bact

148 Among the hundreds of thousands of response regulators identified, variations abound.

149 Deletion of the gene encoding the YxdJ response regulator in both the DAP-R mutant and wild-typ

150 rately knocked out each two-component system response regulator in MP1 and performed competitions aga

151 ression of cfcR, encoding the only GGDEF/EAL response regulator in Pseudomonas putida, is transcripti

152 nes, thereby implicating a role for the DevR response regulator in the regulation of nitrate metaboli

153 However, the role of the third response regulator in the signaling network, HnoC, has n

154 tems in RNA molecules, and kinases and their response regulators in signal-transduction systems.

155 -binding domain (DBD) of only one of the two response regulators in the complex.

156 /or ZTP act as alarmones for a wide range of response regulators in vivo, providing a novel mechanism

157 TPase Ras1, as well as with divergent stress response regulators, including the cell wall kinase Yck2

158 ith VirG and Escherichia coli UhpA, and NarL response regulators indicated compatibility of these bac

159 These are all response regulators involved in signal transduction.

160 nsiveness of ftrA is dependent upon the iron response regulator Irr.

161 dobacteriacae as it contains a putative iron response regulator (Irr) but does not possess a copy of

162 iron directly, the rhizobia employ the iron response regulator (Irr) to monitor and respond to the s

163 nd gel shift assays determined that the AirR response regulator is a direct positive regulator of the

164 ng on how sensory information carried by the response regulator is best utilized by the motor, we ide

165 aponicum transcriptional regulator Irr (iron response regulator) is a key regulator of the iron homeo

166 y determine a suppressive role of the stress response regulators JNK1/2 on LSCC development by acting

167 present structures of DNA complexed with the response regulator KdpE, a member of the OmpR/PhoB famil

168 Activation of LiaFSR through the response regulator LiaR generates major changes in cell

169 mponent kinase yycG/walK and three-component response regulator liaR that locked VRE in diplococcal m

170 show that deletion of the gene encoding the response regulator, LiaR (a member of the LiaFSR system

171 at low cell density, the sigma 54-dependent response regulator LuxO is active and regulates the two

172 The quorum-sensing response regulator LuxO represses type VI secretion gene

173 phorylation and inhibition of the downstream response regulator LuxO.

174 Francisella contains only three response regulators, making it an ideal system to study.

175 tem consisting of a histidine kinase and two response regulators, named herein colony morphology regu

176 ily, the calcineurin-independent, osmostress response regulator NFAT5.

177 evidence that, in the receiver domain of the response regulator nitrogen regulatory protein C (NtrC(R

178 sparent testa glabra2 and HAIKU1 and defense response regulators non-expressor of pathogenesis relate

179 The plant immune response regulator NPR1 resides in either the nucleus or

180 nuclear translocation of the anti-oxidative response regulator, Nrf2.

181 e the free energy landscape of the bacterial response regulator NtrC by combining computation and nuc

182 n in a global activator (gacA), encoding the response regulator of a two-component regulatory system.

183 vation of a gene (mesR) encoding a predicted response regulator of a two-component signal transductio

184 The AccR response regulator of Azoarcus sp. CIB controls succinat

185 that mutation of the ciaR gene, encoding the response regulator of the CiaRH two-component system in

186 red the expression and activity of DegU, the response regulator of the two-component DegS-DegU circui

187 The Agrobacterium tumefaciens VirG response regulator of the VirA/VirG two-component system

188 RcsB, the response regulator of this signaling system, is a pleiot

189 trends in regulatory strategies utilized by response regulators of different subfamilies, and provid

190 Especially, response regulators of two component systems (TCSs), the

191 that FimZ belongs to the family of bacterial response regulators of two-component systems.

192 We also show that the response regulator OmpR, which had previously been hypot

193 re we describe WigK/WigR, a histidine kinase/response regulator pair that enables Vibrio cholerae, th

194 The response regulator PhoP and its cognate sensor kinase Ph

195 that is triggered by phosphorylation of the response regulator PhyR.

196 involving the anti-sigma factor NepR and the response regulator PhyR.

197 g protein, with one of the Chp system output response regulators PilG.

198 We also show that the GlnR response regulator plays a very different role in M. tub

199 st likely functions via the putative cognate response regulator PlrR.

200 The orphan response regulator PmrA is essential for the intramacrop

201 aptor complex includes CpdR, a single-domain response regulator; PopA, a cdG-binding protein; and Rcd

202 Drugs that target the response regulator portion of two-component systems repr

203 e (SK) that detects a signal and activates a response regulator protein to mediate an appropriate out

204 the pack hunting Myxococcus xanthus, uses a response regulator protein, RomR(Mx) (which dynamically

205 TCS) comprising sensor histidine kinases and response regulator proteins are among the most important

206 ction systems, regulating phosphorylation of response regulator proteins that determine the output re

207 Response regulator proteins within two-component signal

208 er and receiver domains of sensor kinase and response regulator proteins, and regulate several cellul

209 n between histidine kinases and their output response regulator proteins, and thus are a good target

210 Implicating sensory histidine kinases and response regulator proteins, both components take advant

211 ther increased in response to nitrite by the response regulator proteins, NarL and NarP.

212 of signaling phosphates to the CheY and CheB response regulator proteins.

213 predict pairing of the histidine kinase and response-regulator proteins forming TCSs.

214 of published data, we have identified PSEUDO-RESPONSE REGULATORS (PRR5 and PRR7) as displaying a high

215 Pseudo response regulators (PRRs) comprise a five-member family

216 PSEUDO-RESPONSE REGULATORs (PRRs) play overlapping and distinct

217 Here we have found that Pseudo Response Regulators (PRRs), essential components of circ

218 ess-induced degradation of YfgM relieves the response regulator RcsB and thereby permits cellular pro

219 SypE contains a central response regulator receiver domain flanked by putative k

220 hitectures except for the loss of C-terminal response regulator receiver domains in the streptophyte

221 ine/aspartate phosphorelays of two-component response regulators, recent work in Mycobacterium tuberc

222 Most activated response regulators regulate transcription by binding ti

223 The DNA-binding response regulator RegX3 is normally activated by phosph

224 onent, causes constitutive activation of the response regulator RegX3, hypersecretion of ESX-5 substr

225 A inhibited gene expression of the stringent response regulator relA, implicated in the regulation of

226 s that impinge on actin cytoskeleton and its response regulators remain largely unknown.

227 ucture of the N-terminal domain of QseB, the response regulator responsible for biofilm formation.

228 that depletion or overproduction of the AirR response regulator resulted in a corresponding decrease

229 /far-red photoreceptor, RfpA, as well as two response regulators (RfpB and RfpC), one of which is a D

230 ing the sensor histidine kinase RgfC and the response regulator RgfA mediate GBS binding to extracell

231 Here, we show that the response regulator RpaA serves as the master regulator o

232 The response regulator RpaB (regulator of phycobilisome asso

233 Expression of the general stress response regulator RpoS and formation of biofilm communi

234 multiple genes including the general stress response regulator RpoS.

235 receptor histidine kinase (HK) and a partner response regulator (RR) and control important prokaryoti

236 oding sequences of histidine kinase (HK) and response regulator (RR) components were codon-optimized

237 tion factor CtrA via an interaction with the response regulator (RR) DivK.

238 Phosphorylation of the response regulator (RR) PhoB has been found to be depend

239 followed by phosphoryl transfer to a cognate response regulator (RR) protein, which may affect gene e

240 otransfers reversibly to two separate output response regulator (RR) proteins.

241 ), having a sensor kinase (SK) and a cognate response regulator (RR), enable the human pathogen Mycob

242 histidine kinase (HK) that phosphorylates a response regulator (RR), modulating its activity in resp

243 his study, EpsW, an orphan and single-domain response regulator (RR), was identified as a potential D

244 ific, with one sensor talking to its cognate response regulator (RR).

245 Two-component systems [sensor kinase/response regulator (RR)] are major tools used by microor

246 ] and a cognate, intracellular effector [the response regulator (RR)].

247 , transferring information toward downstream response regulators (RR).

248 nodule primordium formation, and the B-type response regulator RR1 are expressed in the pericycle in

249 study on the histidine kinase HK853 and its response regulator RR468 from Thermotoga maritima, here

250 f cytokinin primary response genes by type-B response regulator (RRB) transcription factors.

251 bacitracin and nisin, respectively, the two response regulators (RRs) bind their target promoters, P

252 The OmpR/PhoB family of response regulators (RRs) is the largest class of two-co

253 ), together with their partner proteins, the response regulators (RRs), form the ubiquitous two-compo

254 family of transcription factors, the type-B response regulators (RRs), in cytokinin signaling in ric

255 hotransfer proteins and different classes of response regulators (RRs).

256 ent activation of two classes of Arabidopsis response regulators (RRs): the type-B RR (RRB) transcrip

257 regulators, some of which are single-domain response regulators (SD-RRs) such as CheY.

258 Here, we identified the single-domain response regulator (SDRR) SdrG and seven histidine kinas

259 In C. crescentus the CtrA response regulator serves as the master regulator of cel

260 0, thus preventing activation of the cognate response regulator SGO_1181.

261 direct repression of three cytokinin A-type response regulators show its role in balancing meristem

262 phorelays comprised of histidine kinases and response regulators, some of which are single-domain res

263 art by the phosphorylated form of the master response regulator Spo0A (Spo0A approximately P).

264 s largely governed by a circuit in which the response regulator Spo0A turns on the gene for the anti-

265 n by accelerating the phosphorylation of the response regulator Spo0A.

266 sively transferred via relay proteins to the response regulator Spo0A.

267 ulation protein NT-NtrC, and the sporulation response regulator Spo0F.

268 The stringent response regulator SpoT is required for HipA-mediated an

269 ppGpp, the starvation response regulator, strongly inhibits the initiation wit

270 the central phosphotransferase, ChpT, to its response regulator substrate, CtrA, and provide evidence

271 However, the loss of major DNA damage response regulators, such SOG1, partially suppressed the

272 The sulfur response regulator, SurR, is among a handful of known re

273 kinase RscS, which functions upstream of the response regulator SypG to regulate transcription of the

274 The histidine kinase/response regulator system YehU/YehT of Escherichia coli

275 as direct inhibition of the master nutrient response regulator target of rapamycin complex 1 (TORC1)

276 ation site domain and the binding domain for response regulator target proteins.

277 Inactivation of narP, encoding a response regulator that activates napABC transcription i

278 n is also controlled by SypE, a multi-domain response regulator that consists of a central regulatory

279 ently transferring the phosphoryl group to a response regulator that controls downstream effectors.

280 st motile bacteria possess at least one CheY response regulator that is typically dedicated to the co

281 iurnal growth, but mutants defective for the response regulator that mediates transcriptional rhythms

282 LiaR is the response regulator that, upon phosphorylation, binds in

283 at these findings extend to a large group of response regulators that act as transcription factors.

284 -binding proteins are thought to be stimulus-response regulators that bind to signaling phospholipids

285 ing of a sensor kinase and a transcriptional response regulator to detect environmental signals and m

286 histidine kinase (TolRSK) and an independent response regulator (TolRRR).

287 The Arabidopsis type-A response regulators (type-A ARR) are negative regulators

288 Response regulators typically contain conserved receiver

289 or kinase (usually a membrane protein) and a response regulator (usually a DNA binding protein).

290 uranosyl 5'-triphosphate (ZTP), activate the response regulator UvrY, by promoting its autophosphoryl

291 he hybrid sensor kinase BarA and its cognate response regulator UvrY, members of the two-component si

292 conserved aspartic acid (Asp53) of the LytR response regulator was shown to be the target of phospho

293 These signalling complexes phosphorylate a response regulator which in turn governs flagellar motor

294 hosphoryl group to the second component, the response regulator, which activates transcription of tar

295 non-Y-linked, female-specifically expressed response regulator, which produces siRNAs that block thi

296 ms consist of pairs of histidine kinases and response regulators, which mediate adaptive responses to

297 on CSP binding, ComD phosphorylates the ComE response-regulator, which then activates transcription o

298 , and provided insights into interactions of response regulators with their cognate histidine kinases

299 led a role for PAX4, GATA, and the ER stress response regulators XBP1 and ATF6.

300 Chemotaxis response regulator Y (CheY), a 129-amino acid bacterial