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1 the orientation of the base is topologically restrained.
2 ription factor substrates, thereby acting to restrain a neural gene expression program that is aberra
3 y LATS1/2 during pancreas development, which restrains a cell-autonomous deleterious transcriptional
4 Single-cell profiling revealed that Trib1 restrains a population of KLRG1+ effector CD8 T cells th
5 ling and regenerative responses, but instead restrains a protective pathway that inhibits the degener
6 anization and its interactions with the pFRG restrain abdominal activity under resting conditions and
8 , leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation
9 "trap" that elicits an endosiRNA response to restrain acute transposon activity during epigenetic rep
12 SOCS3 secretion as a mechanism by which AMs restrain allergic inflammatory responses in airway ECs.
17 urveillance may supplant the need to handle, restrain, and collect specimens directly from pigs thus
20 main that is here found to be occluded by a "restraining arm" suggesting a self-inhibition mechanism.
21 g3(E123IR) makes intramolecular interactions restraining Atg3's catalytic loop, while E1 and E3 enzym
22 nd context-dependent role for neutrophils in restraining autoreactive B cell activation in lupus.
23 nd functional connectivity patterns, in head-restrained awake and behaving mice, and investigated the
24 and Nr4a3 play partially redundant roles to restrain B cell responses to antigen in the absence of c
27 ve to physically contain and immunologically restrain bacteria growth, some granulomas are unable to
30 led to the synthesis of new conformationally restrained boron-methylated BODIPY photocages that absor
33 ins unclear if these responses are maximally restrained by age-related changes in cutaneous microvasc
34 how that the BCR's capacity to induce CSR is restrained by B cell-intrinsic checkpoints TRAF3 and TRA
35 uctural damages from oxidative reactions are restrained by base stacking and base-pair hydrogen bondi
37 sors, and that this alternative cell fate is restrained by high levels of E protein activity in these
38 biome interacts with its human host has been restrained by limited access to longitudinal datasets to
45 ze starch functionality and digestibility is restrained by the obscurity of their physicochemical nat
46 nificant importance; however, they are often restrained by the solubility and the undesired aggregati
47 r compound lowers intracellular cAMP levels, restrains cAMP-mediated signaling events, and profoundly
52 cells indeed hinder CLL survival in vitro by restraining CD1d-expressing nurse-like cells, a relevant
54 Together, this highlights a pathway that restrains cDC2 and whose reversal enhances CD4(+) T(conv
57 Furthermore, Gab2 knockout in HepG2 cells restrained cell proliferation, migration and tumor growt
63 show that myeloid-derived IL-33 functionally restrains colitic disease, whereas intestinal epithelial
65 e show that EPHA2 maintains pluripotency and restrains commitment by antagonising ERK1/2 signalling.
66 L2 variants, namely aluminum (18)F-fluoride-(restrained complexing agent)-IL2 ((18)F-AlF-RESCA-IL2) a
67 in serial digital mode, which fundamentally restrains computers from handling "big data" efficiently
69 p by restructuring terminal sequences, which restrains conformational dynamics necessary for catalysi
70 y limiting fracture, enhancing stability and restraining continental ice discharge into the ocean, su
72 er, it remains unclear whether and how cells restrain CtIP activity in unstressed cells and activate
73 iciency and the fluorescence lifetime of the restrained cyanine are not extended relative to the pare
74 Runx3 functions and cytotoxicity; and STAT3 restrained cytotoxic gene expression in CD8(+) T cells r
75 ssion of AK017368 promoted proliferation and restrained differentiation of myoblasts; whereas inhibit
76 activation domain of c-Myb was necessary for restraining differentiation, whereas its negative regula
79 inhibitor potentiates antibiotic activity by restraining drug-binding pocket dynamics, rather than pr
80 In particular, how self-reactive B cells are restrained during bystander inflammation in otherwise he
82 K4/6 inhibitors, which eventually results in restraining E2F1 activity, restored miR-223 expression a
83 theory predicts that reproductive effort is restrained early in life to balance the fitness contribu
84 tion of covalent bonds with graphitic carbon restrains edge reconstruction in layered BP particles to
85 tance to ICIs is remarkably limited, perhaps restraining effective development of next-generation imm
86 ared to PD-1 signaling; (2) PD-L1(+) T cells restrained effector T cells via the canonical PD-L1-PD-1
87 l death (RICD) regulates immune responses by restraining effector T cell expansion and limiting nonsp
88 ese findings suggest that mTORC2 in skin DCs restrains effector CD8(+) T cell responses and have impl
92 ot TH12 KR2A, impedes PI(3,4,5)P3 signaling, restrains F-actin polymerization, and inhibits podosome
95 sing multichannel extracellular recording in restrained flesh flies (Sarcophaga bullata of both sexes
96 rom Antarctica, following the removal of the restraining forces of floating ice-shelves after their b
97 elerating development of benign tumors while restraining further progression to malignant cancers.
99 revealed that Aurora kinase B (AURKB), which restrains GC signaling by phosphorylating EHMT1-2, is ov
100 anding of the mechanisms that facilitate and restrain generalization in humans is therefore needed.
103 o find that the fluorescence lifetime of the restrained heptamethine cyanine is temperature-insensiti
105 facial development, alternately promoting or restraining HH pathway activity in a tissue-specific fas
107 ithout affecting overall proliferation, thus restraining HRAS-driven tumorigenesis while maintaining
108 and thereby controls centriole biogenesis by restraining HsSAS-6 recruitment to the mother centriole,
109 ulatory T (Tr1) cells play a pivotal role in restraining human T-cell responses toward environmental
112 PAF1 occupies transcriptional enhancers and restrains hyperactivation of a subset of these enhancers
116 cDC function in advanced PDAC restores tumor-restraining immunity and enhances responsiveness to radi
118 CD8(+) T cells (Tex) remains poorly defined, restraining improvement of strategies aimed at "re-invig
119 uction reveals an inactive BRAF-MEK1 complex restrained in a cradle formed by the 14-3-3 dimer, which
122 calcium influx in CGD neutrophils, which was restrained in WT neutrophils by the electrogenic activit
123 T inhibitors, are paradoxically effective at restraining in vivo and in vitro models expressing MET(N
125 A-dependent synthesis of prosurvival factors restrained infection-inflicted cell death and that exace
126 the physiological importance of PI3Kgamma in restraining inflammation and promoting appropriate adapt
130 the anti-inflammatory responses that act to restrain innate responses remain poorly characterized.
131 sults thus suggest that prenylation normally restrains innate immune responses by preventing Rac1 eff
132 tion at least partially because Tet2 acts to restrain interleukin (IL)-1beta and IL-6 expression in i
135 tion in iTregs increased Foxp3 stability and restrained iTreg conversion into pathogenic T cells.
136 both repress AMPK under basal conditions and restrain its activation by diverse stimuli, thereby prom
137 ed the helical IL-23p19 subunit of IL-23 and restrained its IL-12p40 subunit to cooperatively bind th
138 Since the complexity of TC neuron model restrains its hardware implementation in parallel struct
139 to create genetically encoded platforms that restrain kinase inhibitor drugs at distinct subcellular
140 providing the proof-of-principle that TGIF1 restrains Kras(G12D) -driven PDAC through its ability to
141 response to focal activity in cortex, which restrains laterally propagating activity, including spre
143 n-chest animal preparations, the pericardium restrains LV filling when central blood volume increases
145 ic studies confirmed that SIRPalpha not only restrains macrophages from acquiring a hemophagocytic ph
147 3a, we found that this enzyme is involved in restraining mast cell responses to acute and chronic sti
148 chanisms of peripheral B cell tolerance that restrain mature B cells from mounting inappropriate resp
149 cover crystallographic water structure using restrained MD simulations but that it is not yet reasona
153 hough Hodor sustains gut luminal acidity and restrains microbial loads, its effect on systemic growth
154 everages antibiotic treatment to temporarily restrain microbiota-mediated colonization resistance, an
155 -like factor (KLF)6 promotes inflammation by restraining microRNA-223 (miR-223) expression in macroph
156 a commonly prescribed diabetic medicine can restrain mitochondrial metabolism and tumorigenesis in a
158 gether, these data provide an experimentally restrained model for the inhibited state of the core sig
160 consuming trial-and-error calculations using restrained molecular dynamics (MD) with simulated anneal
162 d binding and folding reaction, we performed restrained molecular dynamics simulations using previous
163 rresponding parent unrestrained variant, the restrained molecule is not subject to photoisomerization
165 duction of D3 in keratinocytes significantly restrains murine BCC tumorigenesis and demonstrate the c
166 T cell homeostasis, the ability of VISTA to restrain naive T cell responses was lost under inflammat
167 hout development limit myc mRNA stability to restrain neuroblast growth and division, and heterogeneo
168 passive coping behaviors while concurrently restraining neuroendocrine activation during exposure to
169 , rather than active, coping behaviors while restraining neuroendocrine activation to optimize adapta
171 cts as a vital gatekeeper of inflammation by restraining neutrophil serine proteases and inflammatory
172 Collectively, our findings show that CITED2 restrains NFkappaB activation and curtails broad pro-inf
173 cytomegalovirus (MCMV)-encoded protein, m12, restrains NK cell effector function by directly engaging
175 xert a differential impact on proactive (the restrain of actions in preparation for stopping) and rea
176 by a combined mechanism that simultaneously restrains ongoing obsolete actions while it facilitates
177 uggest that signaling feedback loops work to restrain or maintain cellular lysosomal content during c
178 th opposite mating-type have either strongly restrained or lost sexual reproduction among themselves.
180 ined by trehalose consumption, which thereby restrains other cells in the trehalose producing, glucon
181 2) is a potent negative regulator capable of restraining overactivation of the renin-angiotensin syst
184 an analogous mouse MDM2 mutant (MDM2 I438K) restrains p53 sufficiently for normal growth but exhibit
185 l AT-rich sequence-binding protein-1 (Satb1) restrains PD-1 expression induced upon T cell activation
186 a key role for the genome organizer Satb1 in restraining PD1 expression and promoting tumor immunity.
188 ur findings demonstrate that stromal lumican restrains PDAC cell growth through mediating cell entry
189 ral bacterium, Porphyromonas gingivalis, and restrains periodontal inflammation through its effect on
191 lly, we found that the B55alpha/PP2A complex restrains PHD-2 activity, promoting EC survival in a HIF
192 in controlling actin cytoskeleton dynamics, restraining PI3K/AKT signaling, and confining B lymphocy
194 ing pathway impinges on the RQC machinery to restrain poly(GR) accumulation, at least in part through
197 ination model revealed no role for ZBTB32 in restraining primary or recall antibody responses against
199 nflammatory responses to atherogenic diet by restraining proinflammatory signaling in endothelial cel
200 t involves the repression of cyclin D1, thus restraining proliferation and repressing RB1, which is r
201 a signaling network of interacting pathways restrains proliferation in normal cells and prevents tum
203 ecreted phosphoprotein 1 (SPP1)/osteopontin, restraining proteolytic activation of SPP1, which led to
204 a very serious health problem, to agree with restraining public policy measures, and to comply with t
206 ots of activating mutations in residues that restrain Ras dynamics and promote the inactive state.
208 Several family members have been found to restrain rather than activate inflammatory cytokines and
209 lular resolution imaging in voluntarily head-restrained rats, we examined the responses of neurons in
210 Here, we develop a machine learning based restrained relaxation protocol that uses deep discrimina
212 oss and structure distortion are effectively restrained, resulting in long-term cycle stability (capa
214 iption factor Thpok, which in CD4(+) T cells restrains Runx3 functions and cytotoxicity; and STAT3 re
215 we present evidence that NOTCH3 functions to restrain secretory differentiation.Conclusions: Basal ce
216 TCR signaling, suggesting that TCR is a self-restrained signaling machinery containing both activatin
217 ur data indicate that the Ormdls function to restrain sphingolipid metabolism in order to limit level
219 campus after status epilepticus (SE) greatly restrained SRS and alleviated cognitive, memory, and moo
221 However, we identify a role for Nur77 in restraining survival of self-reactive B cells in the per
222 l program extensively shared with miR-155 to restrain T cell senescence and sustain CD8(+) T cell ant
224 previously unrecognized molecule, SRSF1, in restraining T cell activation, averting the development
225 ncreases CD8(+) T cell antitumor function by restraining T cell senescence and functional exhaustion
228 negative selection and inhibitory receptors restrain TCR signaling to enforce both central and perip
230 imescales and, hence, it is dynamically more restrained than previous NMR studies have suggested.
236 uctural models additionally suggest TNT1 may restrain the uniform, regulatory translocation of tropom
237 ses, its carboxy-terminal CARD-binding motif restrained the activation of pro-caspase-1/-4/-5/-11.
238 addition, manipulating glutamine metabolism restrained the assembly of stress granules, an indicator
239 lar disease, examine the obstacles that have restrained the development of mitochondria-targeting age
240 gmented the cGMP response to nitric oxide by restraining the activity of phosphodiesterase 5 (PDE5) b
241 the dermis and identify a role for S1PR2 in restraining the egress of tissue-resident lymphocytes.
243 irment of synaptic structure and function by restraining the expression level of active zone (AZ) and
244 overns monogenic TCRbeta expression, thereby restraining the expression of multiple AgRs on alphabeta
245 Further, HIF promoted CD40L expression while restraining the FoxP3-positive CD4(+) cells in the CXCR5
249 equired sophisticated instrumentation, which restrains the accessibility and portability of the analy
250 e pore of the 5-HT(3) receptor (5HT3R) which restrains the backbone structure to that of the parent c
251 ically, Galpha(13) functions as a brake that restrains the c-Src, Pyk2, RhoA-Rock2 mediated signaling
253 ator of the sphingosine-1-phosphate pathway, restrains the egress of CCR7(+) lymphocytes from lymphat
254 forming a local negative feedback loop that restrains the excitatory effect evoked by NMDAR activati
255 a(2+) -dependent negative feedback loop that restrains the excitatory effect on membrane potential an
256 ynapses, provides expiratory inhibition that restrains the expiratory oscillator under resting condit
259 expressed by a subset of memory B cells and restrains the magnitude and duration of recall responses
260 MSCs through the STAT3 signaling pathway and restrains the osteoclastogenesis of rat bone-marrow macr
261 electric field in surface layers effectively restrains the outward migration of bulk oxygen anions.
265 under conditions where cell size increase is restrained, the nucleus becomes bilobed, with the bulk o
267 ps stall replication and the mechanisms that restrain their formation during S phase are incompletely
268 lved question is why some cell lines fail to restrain their high CDK2 activity and hence succumb to C
275 itin is folded back onto the E2 exposing the restrained thioester bond to attack by substrate nucleop
276 ff reported that nursing home residents were restrained through limb and/or trunk restraints in the l
280 y undescribed tumor suppressor in the liver, restraining TNFR1-independent apoptosis in hepatocytes w
282 ed relaxation strategy or relaxation that is restrained to starting structures using the FastRelax ap
284 etic mimics of the Large Latent Complex that restrains transforming growth factor-beta1 (TGF-beta1).
285 ive peripheral afferent nerve fibers in head-restrained transgenic mice expressing ChR2 in TRPV1 cont
286 sexual reproduction can either facilitate or restrain transposable element (TE) accumulation by provi
287 signaling markedly decreased glycolysis and restrained tumor growth, these signaling and metabolic r
291 ngosine 1-phosphate receptors (S1PRs), which restrain vascular endothelial growth factor (VEGF)-induc
292 ly induces the expression of IFN-beta, which restrains viral propagation in neighboring cells involvi
295 h being downstream of TOR, silencing of EBP1 restrains, while overexpression promotes, root growth, m
296 onstrated that trapped beads remained stably restrained with up to eight cell volumes of liquid passi
297 and contains both phosphorylation sites, is restrained within the central channel of the 14-3-3 dime
298 Restraint rates on seven wards receiving the REsTRAIN YOURSELF intervention were compared with those
300 Phosphorylation of KAP1 renders it unable to restrain ZEBRA, thereby further derepressing and sustain