ライフサイエンスコーパス: restraint

1 e scanning given their natural tolerance for restraint.

2 ng effects on acquired behaviors and dietary restraint.

3 lvement in incidents involving seclusion and restraint.

4 on groups studied, was modified by cognitive restraint.

5 es evoked by varying stiffness of mechanical restraint.

6 er studies suggesting its function in action restraint.

7 eads to T cell-mediated immunity and disease restraint.

8 cardiac structure, function, and pericardial restraint.

9 ing pressures through heightened pericardial restraint.

10 ained in the lack of additional experimental restraints.

11 MP using the predicted contacts as distance restraints.

12 chain and the amino group based on chemical restraints.

13 0% of the total number of native contacts as restraints.

14 ny additional rotamer- and backbone-specific restraints.

15 prediction accuracy using native contacts as restraints.

16 are assembled using inter-protomer distance restraints.

17 deprivation, radical stress, and nutritional restraints.

18 ) technique and cross-linking MS/MS distance restraints.

19 ia devoid of the influence of anesthetics or restraints.

20 energy solutions that also satisfy the given restraints.

21 e restrained by interprotomer ssNMR distance restraints.

22 nder the strong influence of solid-state NMR restraints.

23 reflecting the elasticity of the soft-tissue restraints.

24 nt through the use of machine learning based restraints.

25 hat one can achieve with arbitrary number of restraints?

26 ner drugs in female rats throughout repeated restraint abolished their heightened hypothalamic-pituit

27 by secondary structure (DVASS), which ranks restraints according to their importance to RNA tertiary

28 These restraints additionally define the interaction network o

29 the program X-PLOR-NIH based on NMR and SAXS restraints agree remarkably well; even the shapes of the

30 s that are higher than dimer, these distance restraints all have two-fold directional ambiguity, and

31 Staged partial and probabilistic restraint allows mice to adjust to self-initiated headfi

32 esonance spectroscopy (NMR) rely on distance restraints also known as Nuclear Overhauser effects (NOE

33 CR group retained higher degrees of dietary restraint and avoidance of certain foods.After a 2-y int

34 difficult choices, and the extent of public restraint and cocooning of vulnerable populations may sa

35 FpEF was associated with greater pericardial restraint and heightened ventricular interdependence, re

36 ween those involved/not involved in physical restraint and in physical restraint plus seclusion respe

37 miR-182-mediated disruption of TGFbeta self-restraint and provide a mechanism to explain the unleash

38 ressive incidents; coercive measures such as restraint and seclusion should only be used as a last re

39 ction) and 'physical control' (e.g. physical restraint and seclusion).

40 Information about their involvement in restraint and/or restraint plus seclusion incidents was

41 eling and validation to apply conformational restraints and assess agreement with the most common str

42 sing nothing but their simulated profiles as restraints and experimental difference data for individu

43 Protein docking supported by evolutionary restraints and machine learning can be used to reliably

44 tructural informational with sparse distance restraints and search for the most compatible assignment

45 al protocol that leverages observed distance restraints and/or cyclic symmetry (Cn symmetry) found in

46 shape, weight, eating concerns, and dietary restraint), and clinical impairment (Cohen's d=-10.07, -

47 and that motivational engagement, behavioral restraint, and environmental predictability influence it

48 fferent acute challenges, including novelty, restraint, and FS stress, produced distinct glucocortico

49 eating disorder controlling for age, dietary restraint, and intervention condition.

50 ssion, their attitudes towards seclusion and restraint, and their emotions.

51 strongest in the lowest tertile of cognitive restraint, and weakest in the highest tertile.Genetic su

52 benzodiazepines, narcotics, use of physical restraints, and exposure to vasopressors and antiepilept

53 mulated annealing using NOE-derived distance restraints, and the NMR spectra of a series of designed

54 ss-linkers stabilize the fold by macrocyclic restraints, and they also form an integral part of a sma

55 sible that reductions in the use of physical restraint are achievable using a model such as the Six C

56 We further argue that futurity and restraint are life history variables, and that Life Hist

57 tation providers must ensure adequate safety restraints are available, ambulance avoided if possible,

58 al structures with minimum readily available restraints are lacking.

59 l and biophysical data containing structural restraints are not available, but one still wants to obt

60 When the restraints are sorted by DVASS algorithm, using only the

61 d that two intermolecular cross-link-derived restraints are sufficient to generate a high-confidence

62 Thus, the inhibitory restraint arises from a coordinated pattern of activity

63 ptimality theory and confirming reproductive restraint as a key factor underpinning life-history vari

64 itively correlated with their endorsement of restraint as a management technique, but not with their

65 Our model highlights facilitation and self-restraint as interactions that contribute to coexistence

66 esents states of poised potential and active restraint, as stem cells "idle" in anticipation of activ

67 the ability of male rats to exert behavioral restraint at the mere sight of palatable food during the

68 l changes in the KcsA channel removes steric restraints at the selectivity filter, thus resulting in

69 We developed a novel restraint-based method that is capable of reconstructing

70 The lasso structure was confirmed using NOE restraint-based molecular dynamics simulations.

71 By subjecting the models generated by our restraint-based strategy to molecular dynamics (MD) simu

72 r and for obtaining long-range DEER distance restraints between the ASR trimer subunits that were use

73 itio folding using our predicted contacts as restraints but without any force fields can yield correc

74 tion wards there was an average reduction of restraint by 22%, with some wards showing a reduction of

75 le of the convergent evolution of mechanical restraint by overlaying tissues.

76 Voluntary restraints by the food and drinks industry have had litt

77 S algorithm, using only the first 20% ranked restraints can greatly improve the prediction accuracy.

78 ed number of strategically selected distance restraints can significantly assist in RNA structure mod

79 s non-contacts and adding them as additional restraints, can increase the reconstruction accuracy by

80 systematically varied by applying positional restraints, causing the remarkable effect of turning the

81 The restraint consists of myosin IIB- and IIA-dependent proc

82 repulsion, accounting for pairwise distance restraints, construction of homo-multimers, consideratio

83 circumventing requirement for anesthesia or restraint, costly software/hardware, or fluorescently-la

84 Together with complementary restraints derived from cross-linking and native MS, we

85 The distance restraints derived from the cross-links enable building

86 In this study, geometric restraints derived from these experimental data were use

87 Cognitive restraint did not mediate this association (P-Sobel > 0.

88 gnetic relaxation enhancement (PRE) distance restraints, dihedral angle, small-angle X-ray scattering

89 , we introduce two new filters, the distance-restraints (DR) and the Symmetry-Imposed Packing (SIP) f

90 egulation results from either loss of growth restraint due to excess p27 proteolysis or from an oncog

91 These distance restraints enable us to position Psb28 on the cytosolic

92 rect identification of internuclear distance restraints encoded in 3D spectra with automated data ana

93 uantitative mapping between the data and the restraint energy that is calibrated by extensive simulat

94 ue, but not with their actual involvement in restraint episodes.

95 ons, before acute and repeated loud noise or restraint exposures.

96 part of a pre and post-test method, physical restraint figures were collected using prospective, rout

97 rious options, the construction of auxiliary restraints files, the selection of the energy parameters

98 rM-NG during transport and afforded distance restraints for modeling the intracellular facing transpo

99 protein complexes, which are in turn used as restraints for modeling the structures of those analytes

100 Using five cross-links as distance restraints for protein-protein docking, we generated a h

101 ) has been an important source of structural restraints for solving structures of oligomeric transmem

102 , ensuring optimal fitting and generation of restraints for structure calculation.

103 d lanthanide spin label, provided structural restraints for the protein.ligand complex.

104 mechanical ventilation use, coma, delirium, restraint-free care, ICU readmissions, and post-ICU disc

105 n restrained simulations satisfying distance restraints from (13)C-(2)H rotational-echo double-resona

106 ments of the 39 kDa-large subunits, distance restraints from backbone amides and ILV methyl groups, a

107 to that based on chemical cross-links; using restraints from both genetic interactions and cross-link

108 rs to predict multi-resolution probabilistic restraints from the starting structure and subsequently

109 These structural restraints generally confirm the expected binding mode o

110 As expected, accounting for restraints generally improves the rank of near native pr

111 Using restraints generated from both cytb 5 and cyt c, a compl

112 fully solvated SLO model using ENDOR-derived restraints give additional metrical information.

113 s impediment, we have developed a robust NMR restraint guided docking protocol to generate high-quali

114 ted power source access and user wearability restraints have prevented them from taking a constant an

115 Experimental tests of the reproductive restraint hypothesis require manipulation of somatic sta

116 ition of NMR RDC (residual dipolar coupling) restraints improves the structure models.

117 l processing is outside awareness, cognitive restraint in a world of plenty is made difficult and pre

118 stimulation, indicating the central role of restraint in directed outgrowth.

119 experimental cryo-EM density as a structural restraint in molecular dynamics simulations.

120 s and the benefits of incorporating geometry restraints in aiding quaternary structure determination,

121 ectron cryomicroscopy data have been used as restraints in molecular dynamics trajectories to develop

122 policy that explicitly discourages physical restraints in nursing home care and suggests alternative

123 s and NMR chemical shifts used as structural restraints in replica-averaged metadynamics simulations.

124 and residual dipolar couplings as structural restraints in replica-averaged molecular dynamics simula

125 ts were restrained through limb and/or trunk restraints in the last week of life.

126 Such correlations provide unique distance restraints, inaccessible in conventional experiments wit

127 In total, 1680 restraint incidents were logged over the study period.

128 non-invasive experimental procedures without restraint, including fMRI.

129 he characteristic features of conformational restraint, including improved fluorescence quantum yield

130 to constraint (increases with experience) or restraint (increases with age in the face of declining r

131 prior to 2 h restraint stress prevented the restraint-induced increase in DA neuron population activ

132 s comparable across species and is robust to restraint-induced reduction in sensory input.

133 ere, we investigated whether repeated scruff restraint, intraperitoneal (IP) injections and anaesthes

134 Physical restraint is a coercive intervention used to prevent ind

135 When adaptive, the level of reproductive restraint is predicted to be inversely linked to the rem

136 ying only DR, a soluble system with distance restraints is recovered at the 1st-ranked pose.

137 same: NGF-induced weakening of MII-dependent restraint led to dynamic microtubules entering the actin

138 Stiff mechanical restraint led to formation of an extensive actin cup mat

139 ns encircling the disaggregase constitute a 'restraint mask' that sterically controls the mobility an

140 earch into interventions designed to support restraint may help to protect genetically susceptible in

141 c harnessing of the role of stroma in cancer restraint may hinge on our knowledge of the signaling pr

142 vered an evolutionarily conserved allosteric restraint mechanism for Nedd4 ligases and demonstrated i

143 During head restraint, mice make rapid eye movements coupled between

144 This restraint might be because of the poor proliferative cap

145 Cognitive restraint modified the relation between the BMI-GRS and

146 Flexible behavior requires restraint of actions that are no longer appropriate.

147 , we report a new mechanism for TRAF3 in the restraint of B cell survival.

148 t of neutrophils in the dLNs, leading to the restraint of B. anthracis dissemination.

149 Stromal restraint of cancer growth and progression-emerging as a

150 may have helped to provide for the continued restraint of ERV in the human genome.IMPORTANCE Although

151 ntitative BCR signal weakness contributes to restraint of IgE B cell responses.

152 Restraint of intracellular signal transduction pathways

153 ling and involves the capture, elevation and restraint of mice via their tails.

154 uses decreased vinculin-dependent actomyosin restraint of microtubule advance.

155 genes to promote further differentiation and restraint of Notch activity.

156 ed by immune dysregulation due to inadequate restraint of overactivated immune cells and is associate

157 Here we present evidence that checkpoint restraint of spindle extension is directly coupled to Ra

158 strate a role for regulatory T cell-mediated restraint of T(VM) at least in part through limiting IL-

159 agonized type 1 programming, largely through restraint of T-bet expression and function.

160 megakaryocytes and platelets both depend on restraint of the intrinsic (or "mitochondrial") apoptosi

161 ere observed, they contributed little to the restraint of the overall fold.

162 A 3D structure prediction using evolutionary restraints of nucleotide-nucleotide interactions from di

163 could enable microbial genetics free of the restraints of restriction-modification barriers.

164 3 dimers define the topological and mobility restraints of the entire assembly.

165 Spatial restraints of the interaction of this segment with the b

166 ults deepen our understanding of the binding restraints of this CC MBS.LZ PKG-Ialpha low-affinity het

167 to evaluate the impact of the conformational restraint on atomic and orbital structure across the cya

168 s highlight the importance of TRAF3-mediated restraint on BCR signaling strength for controlling CSR,

169 ncluding a pseudoknot provided the strongest restraint on conformational freedom with the effect bein

170 In addition, a restraint on T cell activation by CD6 was revealed in pr

171 demonstrate that FOXF1 expression acts as a restraint on the migratory function of LR-MSCs via its r

172 g a handling tunnel, or cupping mice without restraint on the open hand.

173 ffold and demonstrate the dramatic effect of restraint on the temperature sensitivity of these dyes.

174 ugh the use of cumulative and non-cumulative restraints on 150 benchmarking targets.

175 Thus, glucocorticoids exert bimodal restraints on inflammation characterized by rapid primar

176 Previous work has described powerful restraints on laterally spreading activity in cortical n

177 -terminal acetylation imposes conformational restraints on N-terminal residues in alphaS, thus predis

178 the tryptophans in WT sybII impose sterical restraints on oligomer packing, thereby maintaining an a

179 several risk factors for the use of physical restraints on residents, a practice shown to be neither

180 ed in the simulation process except for weak restraints on secondary structure to enable us to finish

181 d in the active site and provides additional restraints on substrate binding.

182 When combined with restraints on the distance and orientation between helix

183 ns and imposing orientational and positional restraints on the other domains.

184 P hydrolysis with and without conformational restraints on the spring helix further supported the imp

185 nists are characterized by apparently strict restraints on their tertiary or quaternary amine and the

186 fects were not observed in mice subjected to restraint-only stress for an identical period of time.

187 ap suppression by either restoration of fork restraint or gap filling conferred therapy resistance in

188 sordered proteins derived using experimental restraints or by molecular simulations and for proteins

189 s for experimental or bioinformatics-derived restraints or novel structural features to be included,

190 When subjected to either restraint- or glucocorticoid-induced stress paradigms.

191 sses the ability of rats to exert behavioral restraint over the consumption of a visually present suc

192 The fitting of three angular restraints per peptide plane and filtering by Rosetta sc

193 nal predictors of accuracy such as number of restraints per residue, restraint violations, energy of

194 about their involvement in restraint and/or restraint plus seclusion incidents was gathered for the

195 volved in physical restraint and in physical restraint plus seclusion respectively were detected.

196 However, restraint potentiated reinstatement in both sexes.

197 localized to the PrL-PFC and both CORT- and restraint-potentiated cocaine seeking required PrL-PFC C

198 t CT/NG assay, is highly sensitive, but cost restraints preclude implementation of these technologies

199 ow that the application of a small number of restraints predicted by coevolution analysis can provide

200 Male rats underwent an episode of restraint prior to the first conditioning session.

201 Using these restraints, pseudocontact shift-based rigid body docking

202 The restraint rate was significantly lower on the interventi

203 Restraint rates on seven wards receiving the REsTRAIN YO

204 remains inconclusive, and hence reproductive restraint remains to be demonstrated.

205 owards the native state by effectively using restraints remains a major issue in structure refinement

206 ic understanding of pain, but the anesthesia/restraint required to administer electroacupuncture may

207 Minimising the use of restraint requires a multimodal approach to target both

208 We use four restraint resolutions as adopted in GDT-HA (0.5, 1, 2 an

209 Furthermore, by adjusting restraint resolutions, the method addresses the tradeoff

210 forces applied to beads at low stiffness of restraint revealed switching between two states: frictio

211 ination of daily footshock for 10 days and 3 restraint sessions) on (1) midbrain dopamine (DA) neuron

212 oach is that it provides structural distance restraints spanning a range of ca 3-60A while using the

213 e found that mice which experienced repeated restraint spent less time interacting with a handler com

214 Chronic restraint stress (CRS) up-regulated Pdcd4 expression in

215 atients and in mouse vmPFC following chronic restraint stress (CRS), and were increased by ketamine i

216 dala in response to prolonged 21-day chronic restraint stress (CRS).

217 These results suggest that restraint stress activates LH orexin neurons, releasing

218 Neither acute nor chronic intermittent restraint stress altered Gad1 expression in POMC neurons

219 released less corticosterone following acute restraint stress and had lower levels of peripheral IL-6

220 One month of chronic unpredictable restraint stress and inhibition of adult neurogenesis le

221 ompared the effects of chronic unpredictable restraint stress and inhibition of neurogenesis in a rat

222 eural, and endocrine habituation to repeated restraint stress and subsequent cognitive flexibility wa

223 olites immediately at the end of the chronic restraint stress and three weeks after the stress treatm

224 nt in mGlu(3)-LTD following a single, 20-min restraint stress exposure.

225 ment in mGlu3-LTD following a single, 20-min restraint stress exposure.

226 were subjected to a combination of footshock/restraint stress in either adolescence (postnatal day 31

227 Here, we show that acute restraint stress in mice activates lateral hypothalamic

228 this study, we report that chronic physical restraint stress in mice decreases excitability specific

229 Here we demonstrate that chronic restraint stress in mice results in hyperactivity of pro

230 Repeated restraint stress increased BLA neuronal firing and cause

231 Here, we show that acute restraint stress increases cFos expression in CRF neuron

232 Moreover, chronic restraint stress induces bursting action potentials in L

233 Here we show that chronic restraint stress induces the selective loss of p11 (also

234 Restraint stress or optogenetic C1 neuron (C1) stimulati

235 and decreased tumor burden and metastasis in restraint stress orthotopic models.

236 Chronic unpredictable restraint stress over 4 weeks decreased total hippocampa

237 Administration of POM prior to 2 h restraint stress prevented the restraint-induced increas

238 the G(i)-coupled DREADD hM4Di in the PBN on restraint stress regulation of BNST CRF neurons.

239 tients with depression and mice subjected to restraint stress showed elevated PGE2 levels.

240 oth MAM rats and in wild type rats following restraint stress suggests that it can indirectly regulat

241 Restraint stress was applied to pregnant Slc6a4 (+/+) an

242 systemic anaphylaxis and acute psychological restraint stress were measured in WT, CRF(2)(-/-), and M

243 ells are activated following an acute 30-min restraint stress, as assessed by co-localization of CRFR

244 in plasma corticosterone concentrations with restraint stress, but those at 22 degrees C showed no su

245 escent rats that underwent a fixed period of restraint stress, examined whether the gut microbial pop

246 ess the activation marker cFOS in mice after restraint stress, identifying them as potential sources

247 here a powerful anti-inflammatory effect of restraint stress, mediated by C1 neurons: protection aga

248 he novelty-induced hypophagia test following restraint stress-a phenotype that could be blocked with

249 on activity and firing rate and reverses the restraint stress-induced increase in dopamine neuron act

250 levels and colonic permeability after acute restraint stress.

251 nhances neuronal and anxiogenic responses to restraint stress.

252 ors and anhedonia in mice exposed to chronic restraint stress.

253 ion, is significantly upregulated by chronic restraint stress.

254 hippocampal-dependent manner following acute restraint stress.

255 (NAc) of mice exposed to multimodal chronic restraint stress.

256 Acute restraint-stress did not significantly influence mitocho

257 However, acute restraint-stress led to a significant increase in endoge

258 rial and oxidative stress responses to acute restraint-stress, and their relationships with baseline

259 ains of adult mice born from dams prenatally restraint stressed (PRS) during gestation.

260 ther refinement with additional experimental restraints (structure determination) or computational me

261 Here, using an acute restraint-tailshock stress paradigm, we report that both

262 calculation with an electron density fitting restraint that yields an energy reward during the restra

263 heir MS-based identification yields modeling restraints that allow mapping the location and orientati

264 ategy for selection of the minimal number of restraints that would result in the best structural mode

265 By tertiles of cognitive restraint, the association between the BMI-GRS and BMI w

266 Regarding utilization of restraints, the fundamental questions are: (i) What is t

267 mitment, 5) perseverance, 6) self-regulatory restraint to avoid counterproductivity, and 7) proficien

268 nhibit orexin activation throughout repeated restraint to determine if the stress-related impairments

269 , including CYFIP1, acts as a conformational restraint to prevent WASF3 activation.

270 ure from the harmful inertia of sedation and restraints to an animated ICU filled with patients who a

271 n of homologous template and co-evolutionary restraints to AWSEM-Suite greatly improves the predictiv

272 ng structure and subsequently converts these restraints to be integrated into Rosetta all-atom energy

273 ation and bioinformatics data can be used as restraints to improve the accuracy of RNA tertiary struc

274 DEET at equivalent human doses and physical restraint (to induce stress) for 3 weeks followed a 3-we

275 ells with the ability to proliferate without restraint, to invade through tissue boundaries, and to s

276 However, after repeated restraint, tunnel handled mice showed increased willingn

277 s was developed and its impact upon physical restraint usage in mental health Trusts in the United Ki

278 elirium (AOR, 0.60; CI, 0.49-0.72), physical restraint use (AOR, 0.37; CI, 0.30-0.46), ICU readmissio

279 cteristics may not be relevant predictors of restraint use at the end of life in this setting.

280 nd ICU-acquired pressure ulcers and physical restraint use decreased (period 1 vs 2: 39% vs 23% of pa

281 Restraint use was associated with country (p = 0.020) an

282 Restraint use was not significantly associated with resi

283 sure ulcer and higher unit rates of physical restraint use were not associated with higher Pressure U

284 echanical ventilation, coma, delirium, pain, restraint use), and system-related (ICU readmission, dis

285 al docking, accounting for pairwise distance restraints using penalty terms in the scoring function i

286 Restraint violations and RMSD are poor measures of accur

287 cy such as number of restraints per residue, restraint violations, energy of structure, ensemble RMSD

288 Using these experimental data as restraints, we adopted an integrative modeling approach

289 SIP to three HoTPs that comes with distance restraints, we found the near-native poses were ranked 1

290 ent docking in combination with experimental restraints, we present models of the complex structure.

291 In one set of simulations, harmonic restraints were applied to bias the protein structure to

292 Rietveld refinement using geometric restraints were then performed to optimize the positions

293 Limb and/or trunk restraints were used "daily" in the last week of life in

294 ured questionnaire whether trunk and/or limb restraints were used on that resident during the last we

295 l eating, uncontrolled eating, and cognitive restraint-were measured through the use of a validated q

296 iciency in early-stage PDAC leads to disease restraint, while restoration of cDC function in advanced

297 s exhibited impaired habituation to repeated restraint with subsequent deficits in cognitive flexibil

298 combines sparse paramagnetic solid-state NMR restraints with physics-based atomistic simulations.

299 mass spectrometry yielded 17 unique distance restraints within the ECD of the TSHR, its ligand TSH, a

300 The hypothesis was that restraint would be reduced by 40% on the implementation