ライフサイエンスコーパス: resurgent

1 s achieved through vaccination, pertussis is resurgent.

2 d here for the 2013-2014 influenza season of resurgent A(H1N1)pdm09 and late-season type B activity.

3 This was followed by a resurgent activation of the JAK/STAT pathway weeks to mo

4 pes and hormone therapy failures result from resurgent activity of androgen receptor (AR) and the upr

5 dual channels gave openings corresponding to resurgent and conventional transient current.

6 ons revealed enhanced tetrodotoxin-sensitive resurgent and persistent current amplitudes in large, bu

7 ons, and similarly we found an inhibition of resurgent and persistent current by cannabidiol.

8 by wild-type Nav1.6 as well as the aberrant resurgent and persistent current generated by Nav1.6 mut

9 ith prolonged Na(V) open times and increased resurgent and persistent current in native DRG neurons.

10 Correspondingly, resurgent and persistent Na(+) currents were reduced and

11 subunit specifically at the heminode reduced resurgent and persistent Na(+) currents, whereas K(+) ch

12 ion, inhibiting Na(V)1.6 currents, including resurgent and persistent Na(V)1.6 currents, while sparin

13 oms following oxaliplatin, and that enhanced resurgent and persistent sodium currents may provide a g

14 Pertussis is resurgent, and many cases are occurring in vaccinated ch

15 Additionally, transient, resurgent, and persistent sodium current components show

16 treatment of autoimmune disease has led to a resurgent appreciation of B cells as powerful regulators

17 control animal) is helping to dissect a now resurgent area of immunology.

18 this model reproduces the properties of the resurgent, as well as the transient and persistent, Nav

19 ated animals (16 +/- 25, P = 0.037), and the resurgent B cells were primarily of a naive phenotype.

20 CoV2 pandemic continues as of late 2021 with resurgent case numbers in many parts of the world.

21 of diseases such as PCP that coincides with resurgent CD4 T cells, a phenomenon known as immune reco

22 In med cells, the resurgent component of beta-PMTX-modified sodium current

23 The resurgent component of the voltage-gated sodium current

24 range of conditions, sodium currents with a resurgent component promote and accelerate firing.

25 nt for the unusual gating of channels with a resurgent component.

26 mined the contribution of the persistent and resurgent components of voltage-gated Na+ currents in mo

27 luenced hydrothermal systems on the volcanic resurgent cones of Brothers volcano harbor communities o

28 We find that a resurgent continental epidemic could occur as many as 5

29 Resurgent COVID-19 cases have resulted in the reinstitut

30 rome coronavirus 2 (SARS-CoV-2) infection, a resurgent Covid-19 outbreak began in mid-June 2021.

31 t (Patient 1) and the patient with increased resurgent current (Patient 3).

32 found that P10-P14 Purkinje cells exhibited resurgent current (ranging from -3.6 to -15.4 pA/pF in 1

33 pen-channel blocking protein responsible for resurgent current acts as a natural antagonist of lidoca

34 inherited spinocerebellar ataxias, controls resurgent current and repetitive firing in Purkinje neur

35 channel inactivation rate, thereby reducing resurgent current and repetitive spiking.

36 pplication of alkaline phosphatase abolished resurgent current and significantly slowed inactivation

37 ical, molecular and structural mechanisms of resurgent current and their relation to the normal funct

38 Resurgent current appears to depend primarily on NaV1.6

39 ptide, can block open Na channels and induce resurgent current as channels unblock upon repolarizatio

40 ion, and conventional inactivation regulates resurgent current by controlling the extent of open-chan

41 stent current, while Patient 3 had increased resurgent current compared to controls.

42 The generation of resurgent current depends on a factor in the Na(+) chann

43 resurgent Na(+) and K(+) currents, Kv3.1b's resurgent current does not originate from recovery of ch

44 Na channels that generate resurgent current express an intracellular endogenous op

45 ntal studies have led to the hypothesis that resurgent current flows upon repolarization when an endo

46 erlying molecular components contributing to resurgent current have not been fully identified.

47 current clamp to investigate the role of the resurgent current in action potential formation.

48 ent current in wild-type neurons and induced resurgent current in med neurons.

49 rom five species have the capacity to induce resurgent current in mouse hippocampal neurons, which la

50 beta-PMTX increased resurgent current in wild-type neurons and induced resur

51 We observed a correlation between resurgent current inhibition and a drug-mediated increas

52 without Na(V)1.6 lack resurgent current, but resurgent current is absent from many other Na(V)1.6-exp

53 The resurgent current is associated with recovery of transie

54 es more rapidly than in wild-type cells, and resurgent current is nearly abolished.

55 Emerging research suggests that resurgent current is preferentially increased in a varie

56 ality that we discovered is an alteration of resurgent current kinetics, although the mechanisms by w

57 ctions on voltage-gated sodium channels, and resurgent current may be a promising therapeutic target

58 inactivation, leading to the hypothesis that resurgent current may facilitate high-frequency firing.

59 Neurons with resurgent current may therefore be less susceptible to u

60 The macroscopic voltage dependence of resurgent current raises the question of whether the blo

61 Here we report a novel TTX-resistant (TTX-R) resurgent current recorded from rat DRG neurons.

62 Resurgent current results from unbinding of a blocking p

63 n endogenous particle whose unbinding allows resurgent current to flow.

64 t current upon depolarization, but also pass resurgent current upon repolarization.

65 With 50 mM sodium as a charge carrier, the resurgent current was on average approximately 120 pA.

66 missense mutation in Scn8a, steady-state and resurgent current were also reduced, with altered voltag

67 e electrophysiological phenotypes: a loss of resurgent current, a reduction of persistent current, a

68 R1872Q, identifies one common dysfunction in resurgent current, although these mutations alter distin

69 Thus, the presence or absence of resurgent current, and of persistent sodium current, app

70 the necessity of this subunit in generating resurgent current, as well as its influence on Na channe

71 urrent; Purkinje cells without Na(V)1.6 lack resurgent current, but resurgent current is absent from

72 Trypsin and chymotrypsin each removed resurgent current, consistent with established roles for

73 of block, beta4(154-167) fully reconstituted resurgent current, whereas scrambled or point-mutated pe

74 ystems, however, Na(V)beta4 fails to produce resurgent current.

75 rst blocking protein that is responsible for resurgent current.

76 d endogenous block, beta4(154-167) generated resurgent current.

77 etics of NaV1.6 appear well adapted to carry resurgent current.

78 e Na(V)1.6 subunit may lead to production of resurgent current.

79 ent current, and step repolarizations evoked resurgent current.

80 ation at -40 mV, coinciding with the rise of resurgent current.

81 of persistent current and a slowed decay of resurgent current.

82 At -40 mV, this "resurgent" current peaked in 8 msec and decayed with a t

83 nnels in Purkinje cells produce an unusual, "resurgent" current when the cells are repolarized to int

84 sodium channels of Purkinje neurons produce "resurgent" current with repolarization, which results fr

85 ation from positive potentials, producing a "resurgent" current.

86 ated in part by a voltage-gated Na(+) (NaV) 'resurgent' current, which allows renewed Na(+) influx du

87 tions elicit slower channel reopening, or a 'resurgent' current.

88 Resurgent currents (I(NaR)) produced by voltage-gated so

89 ed proexcitatory increases in persistent and resurgent currents and rightward shifts in inactivation

90 Our results indicate that resurgent currents are associated with multiple channelo

91 t kinetics, although the mechanisms by which resurgent currents are augmented remain unclear for all

92 Because resurgent currents are evoked during action potential re

93 Therefore, persistent and resurgent currents are likely to determine whether a mut

94 The TTX-R resurgent currents are similar to classic TTX-S resurgen

95 Resurgent currents arise after relief of ultra-fast open

96 ntial firing in nociceptive neurons and that resurgent currents associated with the Nav1.5 mutation c

97 Computer simulations indicated that resurgent currents associated with the Nav1.7 mutation c

98 Inward resurgent currents at strongly negative potentials, howe

99 0A current density but reduces TTX-resistant resurgent currents by 56%.

100 itions and that enhancement of both types of resurgent currents by inflammatory mediators could contr

101 nsient current amplitude, demonstrating that resurgent currents can be selectively targeted.

102 We propose that these slow TTX-R resurgent currents contribute to the membrane excitabili

103 Additionally, in control gradients, peak resurgent currents decreased linearly with driving force

104 n mutation L955 (DeltaL955) fails to produce resurgent currents despite enhanced persistent currents,

105 However, the TTX-R resurgent currents exhibit much slower kinetics, occur a

106 damide and cannabidiol on peak transient and resurgent currents from wild-type and mutant channels.

107 Tetrodotoxin-sensitive (TTX-S) resurgent currents have been described in many different

108 en observed to mediate unique persistent and resurgent currents in cerebellar Purkinje cells.

109 We also show that both TTX-S and TTX-R resurgent currents in DRG neurons are enhanced by inflam

110 These results suggest that slow TTX-R resurgent currents in DRG neurons are mediated by Nav1.8

111 Our data indicate that increased Nav1.8 resurgent currents in DRG neurons greatly prolong action

112 hannel opening, and increased persistent and resurgent currents in large-diameter dorsal root ganglio

113 urgent currents are similar to classic TTX-S resurgent currents in many respects, but not all.

114 Reduced fast inactivation without increased resurgent currents induces symptoms of IEM, not PEPD, in

115 As such, enhancement of resurgent currents may constitute a pathological mechani

116 that selective attenuation of PEPD-enhanced resurgent currents might contribute to this therapeutic

117 ZL0177 not only decreases the transient and resurgent currents of Nav1.8 and Nav1.9 but also reduces

118 molecular mechanism underlying these unique resurgent currents represents a novel therapeutic target

119 trast, IEM mutations, whenever tested, leave resurgent currents unchanged.

120 d the voltage dependence of block, such that resurgent currents were evoked even after conditioning a

121 The amplitudes of the transient and resurgent currents were highly correlated across patches

122 In reverse gradients, outward resurgent currents were tiny or absent, suggesting that

123 h mutations in Nav1.6 dramatically increased resurgent currents while mutations in Nav1.1 did not.

124 nje cells isolated from embryonic chick have resurgent currents with kinetics and amplitudes indistin

125 gent currents, anandamide strongly inhibited resurgent currents with minimal effects on the peak tran

126 ge-clamp that R185H variant channels enhance resurgent currents within dorsal root ganglion neurons a

127 ugh carbamazepine did not selectively target resurgent currents, anandamide strongly inhibited resurg

128 The G1662S mutation doubled resurgent currents, and the T790A mutation increased the

129 As with TTX-S resurgent currents, they are activated by membrane repol

130 disease-causing mutations lead to increased resurgent currents, unusual sodium currents that have no

131 r insight into the potential mechanism(s) of resurgent currents, we examined whether these inhibitors

132 pen-state inactivation) and did not increase resurgent currents, which have been suggested to contrib

133 PEPD mutations also increase resurgent currents, which involve the voltage-dependent

134 that enhanced SI is accompanied by impaired resurgent currents, which suggests that SI may interfere

135 the three drugs on Navbeta4 peptide-mediated resurgent currents.

136 andamide, exhibit differential inhibition of resurgent currents.

137 , the non-NaV1.6 subunits can produce robust resurgent currents.

138 neurons that produce tetrodotoxin-resistant resurgent currents.

139 induce nociceptor hyperexcitability increase resurgent currents.

140 oportion of the neurons that generate Nav1.8 resurgent currents.

141 SI in order to investigate their effects on resurgent currents.

142 hitherto been considered a prerequisite for resurgent currents.

143 rated by the same mechanism underlying TTX-S resurgent currents.

144 v1.6 is the major contributor to these TTX-S resurgent currents.

145 raised global awareness of the potential for resurgent disease in countries with long-standing immuni

146 sidence within the caldera migrated from one resurgent dome to the other between August 1992 and Augu

147 per square second) centered on the uplifting resurgent dome.

148 remote areas, and we were able to confirm a resurgent epidemic in heterosexual networks in urban are

149 we aimed to find out the extent to which the resurgent epidemic is the result of newly introduced str

150 In the early phases of growth, resurgent epidemic waves of SARS-CoV-2 incidence have be

151 ith the resumption of more normative mixing, resurgent epidemic waves, patterns of waning immunity, a

152 49 is an important consideration in halting resurgent epidemics and preventing COVID-19-attributable

153 that the global scenario is characterized by resurgent epidemics, their number increasing with increa

154 Outbreak data show key resurgent events in 2016-2017 and 2020-2021, contributin

155 major contributions to peak, persistent, and resurgent forms of sodium current and to sustained actio

156 ctive about GPe Na+ channels was a prominent resurgent gating mode.

157 a+ channel models with and without prominent resurgent gating suggested that resurgence was critical

158 ive feedback loop between the persistent and resurgent gating variables which mediate such gain in bu

159 ossessing Nav1.6 Na+ channels with prominent resurgent gating.

160 exploit matrix-released nutrients; and (3) a resurgent growth regime driven by exponential growth of

161 Resurgent HCV replication was temporally associated with

162 In the meanwhile, the resurgent hERG tail currents are dose-dependently inhibi

163 The resurgent HIV epidemic amongst MSM in the Netherlands is

164 es, we demonstrate changes in the origins of resurgent HPAI H5 and reveal significant shifts in virus

165 ged in Scn1b (beta1) null CGNs; however, the resurgent I(Na), thought to underlie high-frequency firi

166 ly prolonged action potentials and inhibited resurgent IK tails from guinea-pig isolated ventricular

167 c amongst men who have sex with men (MSM) is resurgent in many countries despite the widespread use o

168 mporary ectoparasite on humans and currently resurgent in many developed countries.

169 ion than those homozygous for either and are resurgent in modern tomatoes.

170 ocesses based on inorganic crystals has been resurgent in recent years.

171 and deaths remain unacceptably high and are resurgent in several settings, though recent development

172 VRC01 levels were insufficient to prevent a resurgent infection, knowledge that they did not mediate

173 Tuberculosis (TB) is a resurgent infectious disease affecting a large number of

174 to play a major role as a potentially lethal resurgent infectious disease.

175 to respond effectively to the challenges of resurgent infectious diseases, such as tuberculosis, and

176 living species, chimaeroids are the focus of resurgent interest as potential archives of genomic data

177 water-in-salt" electrolytes recently spurred resurgent interest for high energy density aqueous lithi

178 Resurgent interest in antiviral drugs for the treatment

179 The last 10 years have seen a resurgent interest in cardiac intermediary metabolism an

180 ies target metabolic enzymes, and there is a resurgent interest in developing new cancer drugs that i

181 ctor, and, in recent years, there has been a resurgent interest in IFN-gamma biology and its role in

182 p to 24 h after the ischemic event, there is resurgent interest in neuroprotective stroke therapies.

183 However, resurgent interest in technologies aimed at enabling pro

184 l and structural data on these proteins, the resurgent interest in Type IV enzymes as tools for epige

185 illar side of the IHCs selectively express a resurgent K(+) current, highlighting a novel biophysical

186 .1b channels solve this problem by producing resurgent K(+) currents during repolarization, thus ensu

187 r nuclear neurons both have Na currents with resurgent kinetics.

188 ogenous open-channel blocker responsible for resurgent kinetics.

189 Voltage-gated sodium channels with "resurgent" kinetics are specialized for high-frequency f

190 However, mosquito-borne diseases are now resurgent, largely because of the insecticide resistance

191 unbinds at negative potentials, generating a resurgent Na current and permitting rapid firing.

192 Repetitive firing is facilitated by resurgent Na current, which flows upon repolarization as

193 lidocaine-like compounds affect neurons with resurgent Na current.

194 hannel block that approximates physiological resurgent Na current.

195 ayer II neurons by increasing persistent and resurgent Na currents and disrupting channel inactivatio

196 Unlike previously described resurgent Na(+) and K(+) currents, Kv3.1b's resurgent cu

197 calyx terminal revealed the expression of a resurgent Na(+) current (I(NaR)), the amplitude of which

198 Following its initial discovery, resurgent Na(+) current has been found in nearly 20 type

199 Resurgent Na(+) current results from a distinctive form

200 ry Na(+) channel subunit thought to underlie resurgent Na(+) current.

201 (+) current inactivation kinetics, and large resurgent Na(+) currents (I(NaR)).

202 al data and the simulations, we propose that resurgent Na(+) influx occurs as a result of fast inacti

203 membrane resonance and burst generation, the resurgent Na+ can help stabilize burst timing features i

204 the unique electrical properties of Kv3 and resurgent Na+ channels are coordinated to limit accumula

205 highlight a novel role for the voltage-gated resurgent Na+ component in moderating the entropy of bur

206 Moreover, such a physiological role for the resurgent Na+ offered noise tolerance and preserved the

207 e FGF14b N-terminus is a potent regulator of resurgent NaV current in cerebellar Purkinje neurons.

208 , including improved planning for the annual resurgent outbreak, augmented by simple central nationwi

209 Despite excellent vaccines, resurgent outbreaks of hepatitis A have caused thousands

210 with high vaccine coverage have experienced resurgent outbreaks of mumps.

211 gation of severe complications and potential resurgent outbreaks of the virus.

212 ns in Kisii Central and Gucha led to typical resurgent outbreaks whereas exceptional rainfall in Nand

213 se restrictions while minimizing the risk of resurgent outbreaks.

214 Our findings suggest these resurgent parasite populations are highly clonal and tha

215 Identifying the source of resurgent parasites is paramount to a strategic, success

216 ed pronounced slow inactivation (60%-70%) of resurgent, persistent, and transient components of sodiu

217 ssing mainly violent Islamist revivalism and resurgent racial and ethnic supremacism.

218 A resurgent Republican Party will mount a sustained challe

219 20 to 49 are the only age groups sustaining resurgent SARS-CoV-2 transmission with reproduction numb

220 d upon insertion of a catheter, leading to a resurgent secondary infection.

221 The resurgent sodium current (I(NaR)) activates on membrane

222 e upstroke of action potential, we show that resurgent sodium current flows at the peak of afterhyper

223 Resurgent sodium current is an atypical near threshold c

224 activate resurgent sodium current, and thus, resurgent sodium current likely contributes to the forma

225 Grieco and colleagues present evidence that resurgent sodium current results from a novel form of in

226 mV following brief, large depolarizations, a resurgent sodium current rises and decays in parallel wi

227 ter the gating of sodium channels to produce resurgent sodium current, an unusual form of gating in w

228 ramps was reduced to approximately 30%, and resurgent sodium current, an unusual transient current e

229 is similar to voltage patterns that activate resurgent sodium current, and thus, resurgent sodium cur

230 n and unbinds upon repolarization, producing resurgent sodium current.

231 in a functional blocking element and produce resurgent sodium current.

232 Resurgent sodium currents (I(NaR)) are atypical currents

233 c protrusion with loss of planarity, reduced resurgent sodium currents and abnormal glutamatergic neu

234 cent data suggest that, in some CNS neurons, resurgent sodium currents contribute to production of hi

235 Resurgent sodium currents contribute to the regeneration

236 all substantially increased the amplitude of resurgent sodium currents in an optimized adult rat-deri

237 plitudes of whole-cell peak, persistent, and resurgent sodium currents in Purkinje neurons were reduc

238 significantly increased Nav1.8 transient and resurgent sodium currents in the rat small DRG neurons.

239 ve SCI significantly increases transient and resurgent sodium currents mainly through Nav1.8 in rat s

240 vation, significantly increase TTX-resistant resurgent sodium currents mediated by Nav1.8.

241 d that cannabidiol can preferentially target resurgent sodium currents over peak transient currents g

242 sclerosis and known to block persistent and resurgent sodium currents, at pharmacologically relevant

243 abilized inactivation of Nav1.7 and enhanced resurgent sodium currents.

244 a4 peptide in the pipette solution to induce resurgent sodium currents.

245 ng recovery from inactivation, generating a "resurgent" sodium current that flows immediately followi

246 e "persistent" sodium current and a dynamic "resurgent" sodium current, which promotes rapid firing b

247 during repolarization, carrying an unusual "resurgent" sodium current.

248 From 1980 onwards, our model identified resurgent states with increasing accuracy, leading to re

249 ness; discharge, marked by brief respite and resurgent therapeutic and social disruption; and continu

250 ns for increasing interest in methadone as a resurgent treatment for MOUD in the United States and fo

251 r acute infection correlates with subsequent resurgent virus replication and development of neurologi

252 ne high-expression HLA-DPB1 allele predicted resurgent virus-specific T-cell immunity and viral contr

253 te from the response at stimulus onset, is a resurgent visual representation that seems as selective

254 days of symptom onset, in order to prevent a resurgent wave from overwhelming hospital capacity in th

255 implement non-pharmaceutical measures in any resurgent wave.

256 gh modeling efforts; these presumably became resurgent with inexpensive and powerful computing tools.