ライフサイエンスコーパス: retard

1 owly and the development of gametophores was retarded.

2 ubble is present, the evaporation process is retarded.

3 locus, loss of variability is nearly always retarded.

4 interactions with proteins are significantly retarded.

5 mally until birth, but their later growth is retarded.

6 types from essentially wild type to severely retarded.

7 t potential pharmacological interventions to retard AD progression.

8 is a nucleation enhancing and crystal growth retarding additive in palm oil crystallization at 0.7% (

9 abolic function observed upon Policaptil Gel Retard administration is profound and of systemic nature

10 ns unclear whether circadian enhancement can retard aging in mammals.

11 he integument and inform novel approaches to retarding aging and age-related dysfunction in those int

12 Calorie restriction (CR) retards aging and increases longevity in many animal mod

13 chemic injury, mitigates renal fibrosis, and retards AKI progression to CKD.

14 ciation between SHP-1 and PLCbeta3, and then retarding Akt phosphorylation and promoting STAT5 phosph

15 efined mixtures, most of which were found to retard alpha-synuclein aggregation.

16 to-spark delays; (3) inhibiting PKA with H89 retarded amplitude recovery and increased spark-to-spark

17 ta-polyglutamine hybrid peptides designed to retard amyloid maturation and an adjusted thioflavin int

18 ts reveal how perinatal cannabinoid exposure retards an early milestone of development, delaying the

19 s to demonstrate that forced MSI2 expression retards anagen entry and consequently delays hair growth

20 These mice are growth retarded and develop cataracts, lordokyphosis and cachex

21 Untreated Hyp mice were severely growth retarded and had marked alterations in both growth plate

22 We show that Compound-Het mice are growth-retarded and have muscle weakness.

23 photocycle kinetics of bR was significantly retarded and the transient populations of intermediates

24 s where the differentiation of stem cells is retarded and thus reveal how modest changes in autophagy

25 Tumour growth was retarded and vascularity reduced in clec14a(-/-) mice.

26 y of three oral drugs, labetalol, nifedipine retard, and methyldopa for the management of severe hype

27 fertilized, subsequent embryo development is retarded, and the embryos potentially fail to thrive due

28 poorer regeneration that is accounted by the retarded anti-inflammatory macrophage transition and the

29 on in the skin early after antigen challenge retards antigen-specific immunity.

30 ant for methanol oxidation on alpha-Fe2O3 is retarded approximately 20-fold by H/D substitution.

31 ) The hydration dynamics in general are more retarded around beta-sheet structures than alpha-helical

32 ed that Tc(VII) migration can be reductively retarded at Hanford site with a retardation degree depen

33 le recombination of photo-excited charges is retarded at lower temperature.

34 f silicate weathering are typically strongly retarded at temperatures well below 0 degrees C.

35 LKB1-mediated phosphorylation of Thr172, and retards ATP binding to the catalytic alpha subunits.

36 sensitivity for the individual ROS is still retarded because of their high reactivity and the rapid

37 ating layers were specifically favorable for retarding bio-dissolution and mechanical decay of scaffo

38 tration of locked nucleic acid anti-miR-181b retarded both the development and the progression of ath

39 F300-AC or MCG-biochar could obtain sorption-retarded breakthrough times for atrazine of 54 or 5.8 ye

40 Canx null mice are growth retarded but fertile.

41 anoindentation leads to grain growth that is retarded by impurities, and enables quantification of th

42 rved that 1D diffusion by Nhp6A molecules is retarded by increasing densities of the bacterial protei

43 nce to dislocation motion, which can also be retarded by other heterogeneities.

44 The propagation of the reaction front is retarded by redox-sensitive mineral dissolution reaction

45 ds and the magnetic field, target cells were retarded by the magnetic field; transit time of a target

46 vaterite to calcite transformation-which are retarded by the occlusion units, resulting in concentrat

47 rdiomyocytes and signs of heart failure were retarded by the transgenic expression of GRKInh, a pepti

48 interior of rod photoreceptors appears to be retarded by transit across the cytoplasmic gap between p

49 ion) where the spontaneous nucleation can be retarded by trapping of the monomers in an inactive conf

50 the aim of improving corrosion resistance by retarding cathodic activation.

51 Zebularine increases miR-124 expression and retards CC cell growth and invasion with minimal toxicit

52 or-promoting property as knockdown of NFATc3 retarded cell growth in vitro and tumor growth in xenogr

53 g cells in the G2/M phase of the cell cycle, retarding cell growth.

54 the versican V3 splice variant (V3) by ASMCs retards cell proliferation and migration in vitro and re

55 level, PIN1 expression promotes rather than retards cell proliferation.

56 (BDE-209) are photolytically unstable flame retarding chemicals.

57 WDR62 ablation led to retarded cilium disassembly, long cilium, and delayed ce

58 water solubility and bioavailability, while retarding clearance.

59 ipid biosynthesis, resulted in significantly retarded CNS myelination; however, myelin appeared norma

60 inhibits colon cancer cell proliferation and retards colon cancer xenograft growth.

61 These neurons are retarded compared with controls in several morphological

62 This additive also retards compositional segregation into impurity phases a

63 Three types of spatiotemporal response-retarded concomitant release, synchronous release or hie

64 tnnb1 gain-of-function mutant (Ctnnb1(cGOF)) retards corneal epithelium stratification.

65 tion of trafficking between the ER and Golgi retarded COX-2 ERAD.

66 interlocking fibrous building blocks further retard crack propagation at the nanometre scale.

67 significantly affect nucleation but slightly retarded crystal growth.

68 Retard de Croissance Intra-uterin et Paludisme (RECIPAL)

69 OPAs are frequently used to retard degradation in polymers through their oxidation t

70 Surprisingly, in steady-state assays Rpn13 retarded degradation of various single-chain substrates.

71 aesculin suppressed ubiquitination of Nrf2, retarding degradation of Nrf2.

72 lyst in self-hydrating crossover gases while retarding desorption of and capturing free radicals form

73 potentially serve as an adjuvant therapy to retard development of cardiometabolic disease.

74 er carbon content, while embryonic OA stress retarded development.

75 h extreme longevity a consequence of greatly retarded development.

76 ria expressing NAPEs into the gut microbiota retards development of diet induced obesity in wild-type

77 Nevertheless, retarded diffusion combined with H2O2 degradation can li

78 like signaling (IIS) offers a possibility to retard disease onset through induction of metabolic chan

79 Furthermore, 2DG greatly retarded disease progression in both model systems, redu

80 Accelerating or retarding DSB repair did not affect atherosclerosis exte

81 ylline's metabolism and elimination could be retarded due to competition and/or blockage of the CYP2D

82 Fibril growth is further retarded due to reduced mobility of the involved hydrati

83 location and translocation steps, and 3) the retarding effect of ribosome-bound IRES on protein synth

84 The retarding effect of the functional ingredients is relate

85 use at part per million loadings, and to the retarding effect of these low catalyst concentrations on

86 l responses in systemic viral infections and retards effector T cells in autoimmune diabetes.

87 melanoma cells partially rescued the growth-retarding effects of BAP1 loss.

88 ncodes a mitochondria-targeted endonuclease, retarded elimination [8].

89 high temperature, sli1 mutants suffered from retarded elongation of the inflorescence and impaired si

90 cell elongation and that depletion of FMNL3 retards elongation of the intersegmental vessels in zebr

91 nt showed severe seed defects, which include retarded embryo development, reduced seed weight, and re

92 oth catechins did not have a great effect on retarding emulsion oxidation.

93 s altering actin cytoskeletal structures and retarding endocytosis.

94 Dnmt3a/b deletion retards ES cell transition, correlating with delayed Nan

95 decreases bacterial adhesion sufficiently to retard establishment of infection; 2) surfaces that acti

96 ce and determined that these mice are growth-retarded, exhibit partial postnatal lethality, and have

97 trations of dissolved silicate progressively retard Fe(II) oxidation kinetics in the circum-neutral p

98 le of forming complexes with iron hydroxides retarded Fe(VI) decay.

99 N-terminal htt acetylation retarded fibril formation in solution and promoted the f

100 re elongation takes place, which efficiently retards fibril formation.

101 olution (0.5 g maltose/100 g flour), did not retard firming in comparison to reference pellets (crumb

102 simultaneously was a successful approach to retard FO oxidation.

103 ration, colony forming ability as well as in retarded gap closing.

104 In this study, we show that DNA damage retards germline stem cell (GSC) self-renewal and progen

105 orrodens (Ecor-LDC) inhibit LDC activity and retard gingival inflammation in beagle dogs.

106 lpha-amylase inhibitors, thereby potentially retarding glucose liberation from starches and alleviati

107 mer as a competitive allosteric mechanism to retard glycolysis and facilitate metabolic reprogramming

108 gated RNA binding in vitro and significantly retarded granule formation in zebrafish embryos, suggest

109 iminutive mutant exhibits miniature stature, retarded growth and reduced fertility.

110 ated EGFR resulted in poor drug delivery and retarded growth in vivo but not in vitro.

111 Because AREG depletion retarded growth of xenografted ovarian tumors in mice, w

112 ontrast, swp73b mutants are characterized by retarded growth, severe defects in leaf and flower devel

113 mentation, smaller leaf and plant sizes, and retarded growth.

114 We show that Policaptil Gel Retard has remarkable, beneficial effects on metabolic d

115 y exerting effects on cellular senescence to retard HCC progression.

116 Anodic bias significantly retards hematite recombination dynamics, and causes the

117 dditionally, H4 K5K8 butyrylation also marks retarded histone removal during late spermatogenesis.

118 horesis demonstrated that 60% sorbitol could retard hydrolysis of OVT completely for a period of time

119 ncy impairs ER expansion in plasma cells and retards immunoglobulin production.

120 expressing OsACBP2 (OsACBP2-OE), osacbp2 was retarded in germination, while OsACBP2-OEs performed bet

121 Autocatalytic activation was retarded in glyco-pro-KLK2, whereas the activated glyco-

122 evelopment and growth of B16-F0 melanomas is retarded in mice lacking C3aR, whereas growth of establi

123 The transition from state 2 to state 1 was retarded in pph1, and surprisingly also in pbcp However,

124 rumb by anti-staling enzymes, the staling is retarded in the middle.

125 This autodegradation was retarded in the presence of alginate (an extracellular m

126 ed organic compound degradation kinetics are retarded in the presence of methanol and natural organic

127 The oxidative degradation of ceMoS(2) was retarded in the presence of natural organic matter (NOM)

128 This chain transfer process is retarded in the sandwich system.

129 to better preserve bio-active compounds and retard increases in MC, aw and DB, when compared to poly

130 Genetic Gpr132 deletion not only retards inflammation and cancer growth but also abrogate

131 iptional activator of the NF-kappaB pathway, retards inflammation and impedes proliferation at the ea

132 nts of ATP release indicate that G100V/C103V retards initial fusion-pore opening, hinders its expansi

133 ith early Plasmodium falciparum exposure had retarded intrauterine growth between gestational ages of

134 helium of the developing nasal cavity, which retards invagination of the nasal cavity, and thus appea

135 tial pharmacological treatment strategies to retard its progression in vivo.

136 rastically, but encapsulation in proniosomes retarded its degradation.

137 rilipin 1 that binds and stabilizes ABHD5 by retarding its degradation by the proteosome.

138 kali supplementation in CKD as it relates to retarding kidney disease progression, improving metaboli

139 Conversely, Rab18 knockdown retards LD loss in culture and blocks activation, just l

140 rought-sensitive soil invertebrates, thereby retarding litter decomposition and nutrient cycling in e

141 e water for 15 min increased fruit firmness, retarded losses in ascorbic acid, titratable acidity, an

142 e, PMNs impeded early-stage tumor growth and retarded malignant progression.

143 Conditional deletion of THAP1 in the CNS retards maturation of the oligodendrocyte (OL) lineage,

144 the physicochemical changes during storage, retarding microbial growth and retaining the bioactive c

145 the quality of fresh and frozen products by retarding microbial growth, reducing lipid oxidation and

146 significantly reduced proliferation rate and retarded migration capabilities.

147 controversial because ROS scavengers fail to retard mitophagy.

148 t that oncoprotein E7 of HPV16 but not HPV18 retards mitotic progression in host cell by direct bindi

149 iffusion, in stark contrast to exponentially retarded mobility, coupled to weak anomalous subdiffusio

150 at the strip edges, allowing accelerated or retarded motion of magnetic vortices inside the supercon

151 ination with the MEK inhibitor trametinib to retard MPNST progression in transgenic fish overexpressi

152 oth in augmenting hedgehog signalling and in retarding myelination is specialized.

153 uce ocular hypertension and is effective for retarding myopic progression.

154 of axitinib, an inhibitor of VEGF receptors, retarded neo-angiogenesis that was associated with defec

155 nd loss of function of these channels at NRs retards nerve conduction and impairs sensory behavioral

156 scaffolds exhibited fast biodegradation and retarded new bone regeneration after 8 weeks.

157 lifespans of these progeroid mice, strongly retarding numerous aspects of accelerated ageing.

158 d grafted polypropylene copolymers (PP-Tann) retarded oligomerization of the linseed oil.

159 hysiology and/or community composition could retard or accelerate soil carbon losses.

160 that augmentation of torsinB expression may retard or prevent symptom development in DYT1 dystonia.

161 It may retard or reverse divergence of species, enable the deve

162 Next-generation pressure-retarded osmosis (PRO) approaches aim to harness the ene

163 ces sustainable energy by combining pressure-retarded osmosis (PRO) as a power generation stage and m

164 Osmotic power generated by pressure-retarded osmosis (PRO) has attracted global attention as

165 rvesting technologies, specifically pressure-retarded osmosis (PRO) in this work, is hindered by the

166 Pressure-retarded osmosis (PRO) is a promising source of renewabl

167 ance of osmotic power generation by pressure-retarded osmosis (PRO) processes, fouling on PRO membran

168 on was that in "breakthrough mode", Pressure-Retarded Osmosis (PRO) would generate very high power de

169 ric membrane for fouling control in pressure-retarded osmosis (PRO), an emerging engineered osmosis p

170 nges of the foremost technologies - pressure retarded osmosis (PRO), reverse electrodialysis (RED), a

171 Several technologies, including pressure-retarded osmosis (PRO), reverse electrodialysis (RED), a

172 eduction that can be achieved using pressure-retarded osmosis (PRO).

173 orced induction of this exon-exclusion event retarded osteoblastic differentiation in vitro and inhib

174 group are found to be the most effective at retarding oxidation in air.

175 arious industrial and commercial products to retard oxidative reactions and lengthen product shelf li

176 ibit enhanced damage that corresponds with a retarded p38-MAPK-dependent transition of their macropha

177 deletion in SMCs, but not endothelial cells, retarded PA medial thickness.

178 rchical assembly of interfacial nanowires to retard penetrating cracking.

179 tent, ntrc-trxx mutants showed severe growth-retarded phenotypes, decreased photosynthesis performanc

180 ected fruits against excessive mass loss and retarded physic-chemical changes related to maturation.

181 sure for 16h maintained postharvest quality, retarded physiological disorder and enhanced nutritional

182 Furthermore, the already growth-retarded phytochrome mutants are less responsive to grow

183 of cells in the G2 phase of the cell cycle, retarded plant growth, consistently decreased the size o

184 RTEL1 deficiency retards plant growth, a phenotype including a prolonged

185 , finding that such DNA modifications indeed retarded Pol II elongation on gene bodies.

186 hat led to slow germination rates as well as retarded post-germination growth, shorter root length, a

187 with hostile environments at the expense of retarding post-embryonic development.

188 androgen-mediated organoid organization; and retards postnatal prostate development.

189 le DNA translocations to overcome an applied retarding potential of tens of millivolts.

190 CRPH retarded primary and secondary oxidation in emulsions as

191 ruption of the Arp2/3 complex in murine RGCs retards process outgrowth toward the basal surface and i

192 functional models of cartilage and tendon is retarding progress in this field.

193 kidney disease (CKD) could improve care and retard progression to end-stage renal disease.

194 NKX3.1 acts by retarding proliferation, activating antioxidants, and en

195 ber wood to enhance its mechanical and flame-retarding properties.

196 Incorporation of gum arabic retarded rancidity development during storage.

197 o ratify, interpret, and apply: to calculate retarding rate constants, optimize reaction conditions,

198 persions of nanomaterials typically focus on retarding reaggregation, for example via surface modific

199 ing in incomplete processing of 18S rRNA and retarded recycling of late-acting ribosome biogenesis fa

200 alpha induced sensory nerve degeneration and retarded regeneration in normal corneas.

201 While CNTF neutralization retarded reinnervation in normal corneas, exogenous CNTF

202 roduces Newton colors if one of the beams is retarded relative to the other by from 400 nm to 2000 nm

203 utations that perturb the septin G interface retard release from these chaperones, imposing a kinetic

204 osan coated alginate beads provided the most retarded release of caffeine in water.

205 because it can reduce proteinuria and hence retard renal function decline, but the proteinuria reduc

206 rcomplexes, however, is impaired, leading to retarded repair of damaged proteins.

207 ells accumulate in early S-phase, exhibiting retarded replication fork kinetics and reduced ATR kinas

208 uired to determine the drug doses which best retard resistance emergence in patients.

209 the EC, in the absence or presence of Akt2, retards retinal angiogenesis, implying that Akt1 exerts

210 ting epigenetic modifications and preventing/retarding retinopathy in patients with diabetes.

211 Chlorella sp. + PSO coatings retarded ripening, maintained firmness, mass, and a gree

212 fresh produce that slows down food decay by retarding ripening, dehydration, and microbial invasion

213 cY exhibited anomalous diffusion, had highly retarded rotational dynamics, and aligned their dipoles

214 tive protein in collagen biosynthesis, which retards secretion of type I collagen and causes excessiv

215 Incorporation of glucose polymers with MPI retarded sedimentation of protein during accelerated phy

216 xis in muscle and heart and accounts for the retarded shift of their PCCs.

217 However, they retard significantly in postnatal growth and development

218 ants as measured by antioxidant capacity may retard skin aging among healthy men and women aged >45 y

219 synaptobrevin-2 for the 1:1 complex, thereby retarding SNARE assembly and vesicle docking in vitro.

220 hum flours, and high levels of soluble fibre retarded starch retrogradation in wheat, quinoa and amar

221 and transversal directions is progressively retarded, suggesting a scale-dependent, hierarchical dis

222 Remarkably, we find that retarded surface transport of Li plays a decisive role i

223 typic changes including delayed growth rate, retarded swarming motility, and pyocyanin overproduction

224 sin-converting enzyme inhibitors (ACEIs) may retard the development of CAV but have not been well stu

225 on or activity of these PDEs may, therefore, retard the development of PKD.

226 ate hydrogel was not reduced sufficiently to retard the diffusion of caffeine from the beads.

227 Two amino acid substitutions I138M and I139M retard the formation of parallel in-register beta-sheet

228 These pouches also retard the formation of some common off-flavor compounds

229 stoichiometric amounts of Zn(2+) effectively retard the generation of amyloid fibrils.

230 bout an axis normal to the interface acts to retard the growth rate of the instability and stabilise

231 short hairpin RNA (shRNA) silencing of CD24 retard the growth, progression and metastasis of prostat

232 ion, the presence of beta-glucan appeared to retard the hexanal production in lipid oxidation.

233 pH-responsive hydrogels loaded with PTB can retard the initiation of and facilitate the recovery fro

234 of O5 and known to extend the lag phase and retard the O2 release phase (slow phase) in this critica

235 ults demonstrate that mechanical loading can retard the pathologic progression of OA at its early and

236 controllability on self-assembly morphology retard the peptide-related exploration.

237 Bacteria captured on the surface of biochips retard the PL maximum, while growth of these bacteria fu

238 The same optical forces also retard the plasma expansion, opening avenues for neutral

239 ggregate formation in culprit proteins could retard the progression of amyloid diseases.

240 trials suggest that protein restriction may retard the progression of CKD toward ESRD.

241 show that G-quadruplex stabilizing compounds retard the progression of replication forks leading to a

242 In order to retard the rate of development of antibacterial resistan

243 these phenotypically resistant bacteria can retard the rate of microbiological cure by antibiotic tr

244 roups conjugated to the alkyne significantly retard the reaction rate.

245 d to potentially prevent drug resistance and retard the recurrence of brain tumors.

246 at conditions that destabilize HMW oAbeta or retard the sequestration of smaller, more bioactive comp

247 conditions that destabilize HMW oligomers or retard the sequestration of their smaller, more bioactiv

248 oring of intermediates is widely accepted to retard the shuttle of polysulfides in a working battery.

249 of functional ingredients in the cake batter retard the starch gelatinization.

250 to red-shifted absorption, while that on C7 retarded the charge transfer due to twisting in the stru

251 Gingerols infusion retarded the deterioration of all quality parameters and

252 Moreover, GMFG knockdown retarded the efficient recycling of beta1-integrin back

253 After gradient optimization, the RP-column retarded the eluted polar compounds and split-off the sa

254 angiogenesis in ischemic tissues, therefore retarded the foot blood perfusion recovery.

255 We found that delayed myelination retarded the formation of nodal channel clusters and alt

256 BETis retarded the growth of BPDCN xenografts, supporting thei

257 On the other hand, Dot1L knockdown severely retarded the growth of the tadpoles and led to tadpole l

258 However, it retarded the increase in moisture loss and maintained bo

259 uble content and ascorbic acid were reduced; retarded the loss of titratable acidity during 96h after

260 inished the siRNA concentration in RISC, and retarded the mRNA knockdown.

261 Oligonucleotides targeting mouse Angptl3 retarded the progression of atherosclerosis and reduced

262 ion showed that the incorporation of silicon retarded the thermal decomposition and improved the ther

263 ion of 2 wt % clay particles to sand greatly retarded the transport of all Hg species, especially und

264 Mixed surfactant assembly was successful in retarding the degradation of curcumin in alkaline media

265 on distinct and incompatible platforms(2-8), retarding the development of AGI.

266 patially defined role for Aurora-B kinase in retarding the end-on conversion process.

267 e and controls the rate of ATP hydrolysis by retarding the expulsion of ADP.

268 cing pH value, TBARS and TVB-N contents, and retarding the softening of fish texture compared to cont

269 non-covalent interactions (NCIs) rather than retarding the transformation of the minor isomer through

270 ggesting that some aspect of MS pathobiology retards the accumulation of beta-amyloid but not the acc

271 s not affect enzyme catalysis but instead it retards the degradation of hTDO through the ubiquitin-de

272 portionately required by resistant parasites retards the evolution of drug resistance by intensifying

273 The catalyst retards the formation of the incipient N-C bond from imi

274 Deletion of Mxr1 retards the growth of P. pastoris cultured in YNBA suppl

275 vation of phoP, phoQ or Sant_4061 completely retards the growth of S. praecaptivus in the presence of

276 of Bcl2 results in decreased HR activity and retards the repair of DSBs induced by HZE particles (i.e

277 of loss of both arabinoxylan and starch, and retards the spread of both degradation processes across

278 RH active site-directed isoquinolone ligand retards the subunit-selective RH' domain unfolding behav

279 e cAMP, by maintaining interdomain coupling, retards the unbinding of the B-site cAMP and stalls an u

280 n B16rho(0) cells abolished or significantly retarded their ability to form tumours.

281 ng the fruits' mass loss, and, consequently, retarding their senescence.

282 hibition of its expression could effectively retard these processes.

283 f quorum sensing in the Drosophila intestine retards this process by repressing V. cholerae succinate

284 monstrated that B2 RNA binds stress genes to retard transcription elongation.

285 ams with cannabinoids during early lactation retards transcriptional upregulation and expression of K

286 rm hypoxic conditions to simulate normal and retarded transit scenarios in microvasculature.

287 nt p53 and the dominant-negative effect; and retard tumor growth in xenografts when administered in a

288 Macrophage ablation retarded tumor growth, whereas reconstitution with galec

289 n of pyruvate reduces histone expression and retards tumor growth in xenograft mice without significa

290 Blockade of angiogenesis can retard tumour growth, but may also paradoxically increas

291 wth of multiple Arabidopsis gcn2 mutants was retarded under excess light conditions, implicating the

292 king Psb28-1 and Psb27, but not Psb28-2, was retarded under high-light conditions and, especially, in

293 As single drugs, nifedipine retard use resulted in a greater frequency of primary ou

294 nd therefore cholesterol synthesis), viperin retards viral budding from infected cells.

295 Future studies should therefore focus on retarding VSMC apoptosis whilst promoting VSMC prolifera

296 vibrations of the water network reveals that retarded water motions near the membrane shift the vibra

297 ces of both viscous damping and solid-liquid retarding were analyzed in evaluating contact line frict

298 le most of the hydration shell is moderately retarded with respect to the bulk, some water molecules

299 ion in the diffusion columns was reductively retarded with retardation degrees correlated with Tc(VII

300 epidermal Ca(2+)(i) response to wounding and retarded wound healing were observed in the keratinocyte