ライフサイエンスコーパス: retinal

1 d with the visual pigment chromophore, 9-cis-retinal.

2 To measure retinal activity in the awake, intact brain, we imaged t

3 Overall, these findings showed that 9-cis-retinal administration restored visual pigment formation

4 Here we report a population of retinal amacrine cells that do not develop dendritic arb

5 ter the intraocular pressure normalized, the retinal and choriocapillaris vascular perfusion showed f

6 pigment epithelium degeneration followed by retinal and choroidal thinning, characteristic phenotype

7 hat cause the loss of ClC-2 function lead to retinal and testicular degeneration and leukodystrophy,

8 d to the results of the CT scan, to identify retinal and vitreous hemorrhages consistent with TS.

9 rmational distortion of the prosthetic group retinal, and 2) charge separation between the protonated

10 acids (PUFAs) form cellular, mitochondrial, retinal, and other membranes highly important in neurona

11 orer baseline visual acuity, and presence of retinal angiomatous proliferation had a higher risk of g

12 The patient was found to have anti-retinal antibodies against carbonic anhydrase II and eno

13 rmore, the 9-cis-retinal treatment decreased retinal apoptosis as shown by the terminal deoxynucleoti

14 t transform all-trans-retinal back to 11-cis-retinal are associated with mild to severe forms of reti

15 this species, showing a posteriorly located retinal area with photoreceptor: ganglion cell convergen

16 n (AMD) is a highly effective advance in the retinal armentarium.

17 as grade 1 hypertension demonstrated higher retinal arterial baseline diameter fluctuation (p = 0.00

18 lar inflammation (IOI), endophthalmitis, and retinal arterial occlusion in the phase 3 HAWK and HARRI

19 rcentage of eyes in the thinnest quartile of retinal arteriolar diameter increased with worsening DR

20 Congenital mydriasis and retinal arteriolar tortuosity are associated with the li

21 All three had prominent retinal arteriolar tortuosity.

22 Acute management of retinal artery occlusions involves a multidisciplinary a

23 These features included components of outer retinal atrophy (e.g., ellipsoid zone disruption), compo

24 e retinal pigment epithelium (RPE) and outer retinal atrophy (e.g., RPE perturbation with associated

25 hould be seen in the larger context of outer retinal atrophy, previously suggested as a new form of a

26 ng trafficking of nutrients and metabolites, retinal attachment, and interactions needed for normal o

27 qAF), indicated chronic impairment in 11-cis-retinal availability and provided information on mutatio

28 act brain, we imaged the synaptic boutons of retinal axons in the superior colliculus.

29 nts to the pathways that transform all-trans-retinal back to 11-cis-retinal are associated with mild

30 tempt to investigate the mechanisms of blood-retinal barrier (BRB) breakdown at a global level, we st

31 In retinal-binding proteins, mainly two mechanisms exist to

32 st not only lowers IOP, but may also enhance retinal blood flow in POAG patients with a normal IOP.

33 dy aimed to evaluate longitudinal changes in retinal blood flow in response to flicker stimulation an

34 Longitudinal assessments of retinal blood flow in response to flicker stimulation an

35 G-Micro provides consistent and reproducible retinal blood flow measurement in adult mice.

36 On day 1 of the experiment, retinal blood flow was assessed every 20 s for 6 min dur

37 flicker light (12 Hz) stimulation; on day 2, retinal blood flow was measured every minute for 20 min

38 to measure retinal oxygen contents and total retinal blood flow, respectively.

39 Leakage of retinal blood vessels, which is an essential element of

40 akic RD, with greater occurrence of inferior retinal breaks and inferior retinal involvement in parti

41 raphy provided a quantitative measurement of retinal capillary changes associated with ischemia that

42 Roughest and Kirre, which coordinate apical retinal cell patterning at an earlier stage, accumulate

43 A complete molecular atlas of retinal cell types provides an important foundation for

44 vel, we studied the gene regulation of total retinal cells and retinal endothelial cells during non-i

45 Total retinal cells and retinal endothelial cells from naive a

46 an earlier stage, accumulate within Sac1(ts) retinal cells due to impaired endo-lysosomal degradation

47 RNA-Seq analysis of total retinal cells mainly brought to light upregulation of ge

48 In parallel, VEGF produced by mixed retinal cells or by mesenchymal stem cells exerted a par

49 ummarization of the current understanding of retinal changes that have been identified using advances

50 ideas from information theory, an efficient retinal code could be defined as one that reduces redund

51 redundancy reduction hypothesis, a theory of retinal color coding emerged in which the three most com

52 alization and quantification of fluid in all retinal compartments was applied for automated segmentat

53 ity IRD provides a unique insight into outer retinal complex function.

54 n or snake TRP channels in light-insensitive retinal cones in a mouse model of retinal degeneration.

55 e to isomerize from the 11-cis- to all-trans-retinal configuration.

56 on of subclinical multiple sclerosis-related retinal damage and visual dysfunction.

57 ients with mutations in PRPH2 exhibit severe retinal degeneration characterized by vast inter- and in

58 s mice for the G90D mutation did not exhibit retinal degeneration whereas homozygous mice exhibited p

59 formation and decreased oxidative stress and retinal degeneration, which resulted in improved visual

60 hereas homozygous mice exhibited progressive retinal degeneration.

61 nsensitive retinal cones in a mouse model of retinal degeneration.

62 Inherited retinal degenerations (IRDs) are at the focus of current

63 ll types in the diseasesettings of inherited retinal degenerations and age-related macular degenerati

64 tion are critical to understanding sight and retinal degenerations that lead to blindness.

65 n-related anxiety in patients with inherited retinal degenerations.

66 comes in animal models of retinal injury and retinal degenerative disease.

67 function or morphogenesis leads to blinding retinal degenerative diseases, the majority of which hav

68 ould have significant prophylactic value for retinal degenerative diseases.

69 g clinical examination results (2 eyes), and retinal detachment (1 case).

70 ated the risk and risk factors for exudative retinal detachment (ERD) in ocular inflammatory diseases

71 Exudative retinal detachment (ERD) localized to the infratemporal

72 condary pars plana vitrectomy (P = .009) and retinal detachment (P = .022).

73 orrected visual acuity (BCVA) and tractional retinal detachment (RD) in her left eye, 3 years after t

74 s both functional and anatomical outcomes of retinal detachment (RD) repair by vitrectomy and perfluo

75 ative OCT (iOCT) utility and outcomes during retinal detachment (RD) repair.

76 omes of primary uncomplicated rhegmatogenous retinal detachment (RRD) repair using pars plana vitrect

77 es of comparable pseudophakic rhegmatogenous retinal detachment (RRD) treated with pars plana vitrect

78 g vitrectomy with silicone oil tamponade for retinal detachment by a single surgeon using different o

79 f TT measurements in a validation dataset of retinal detachment images.

80 estigations for possible causes of exudative retinal detachment were performed with unremarkable resu

81 en 2008 and 2016, and the risk of developing retinal detachment within 1 year of the index ERM surger

82 hs of worsening or development of tractional retinal detachment, folds, dragging, breaks, rhegmatogen

83 rm silicone oil tamponade after PPV to treat retinal detachment, IOP increased significantly in patie

84 raocular pressure, and 4 eyes demonstrated a retinal detachment.

85 Both patients had exudative retinal detachments (ERD).

86 d classical RGC signaling pathways mimicking retinal development in vivo.

87 All patients had severe grades of arrested retinal development with lack of a foveal pit and no con

88 During retinal development, TPBG expression increases dramatica

89 re that might contribute to CaMKII-dependent retinal diabetic complications.

90 There were significantly more deep inner retinal dimples in the temporal group (35%) compared wit

91 genital amaurosis (LCA) is a known inherited retinal disease (IRD) associated with severe visual loss

92 Retinal diseases are frequently characterized by the acc

93 ighted the potential for curing degenerative retinal diseases from intrinsic cellular sources.

94 tion, and neovascularization associated with retinal diseases in animal models.

95 ssociated with a broad spectrum of inherited retinal diseases ranging from severe autosomal recessive

96 tential nonhematopoietic roles in neural and retinal diseases, including diabetic retinopathy.

97 Inherited retinal disorder (IRD) is a leading cause of blindness,

98 stent with largely nonprogressive peripheral retinal dysfunction.

99 and enolase proteins with a negative genetic retinal dystrophy panel.

100 targardt disease (STGD1), known as inherited retinal dystrophy, is caused by ABCA4 mutations.

101 , and by the expression of PCARE harboring a retinal dystrophy-associated missense mutation.

102 are associated with mild to severe forms of retinal dystrophy.

103 nked given that they both depend strongly on retinal eccentricity and both are similarly affected in

104 We manipulate sensory uncertainty by varying retinal eccentricity.

105 Retinal endothelial cell sorting in wild type C57BL/6 mi

106 e gene regulation of total retinal cells and retinal endothelial cells during non-infectious uveitis.

107 Total retinal cells and retinal endothelial cells from naive and EAU mice were s

108 d by comparative transcriptome analysis with retinal endothelial cells sorted from Tie2-GFP mice, whi

109 Retinal endothelial cells were isolated by flow cytometr

110 ferential expression of regional genes and a retinal enhancer RNA at this locus was assessed by qPCR.

111 -TAD with ectopic contacts between GDPD1 and retinal enhancers, and modeling of all RP17 SVs was cons

112 the effects of aging and, independently, of retinal environment age on their GABA(A) receptor (GABA(

113 isexpression of miR-183 cluster in the human retinal epithelial cells leads to the reprogramming and

114 Taken together, these data support the retinal equilibrium binding hypothesis.

115 ical analysis of neuronal function in rodent retinal explants is useful for the study of early damage

116 ceptors, but also for repression of specific retinal fates and alternative gene regulatory networks.

117 h ILMP and JPL (16 patients), PPV plus inner retinal fenestration (18 patients), and PPV plus autolog

118 d for structural integrity of the Drosophila retinal floor.

119 eline, as well as first sustained absence of retinal fluid and intraretinal fluid as evaluated by OCT

120 Of the 1127 eyes, retinal fluid was present in 32.8%.

121 "Inferred sensitivity" accurately reflected retinal function in patients with GA.

122 - mice showed no effect of ERdj5 ablation on retinal function or photoreceptor survival.

123 Retinal fundus photography is a safe imaging technique u

124 s and fusion protein optic atrophy 1 (Opa1), retinal ganglion cell (RGC) dysfunction and visual loss

125 total number of Nissl-stained neurons in the retinal ganglion cell (RGC) layer in the Caribbean and C

126 oding emerged in which the three most common retinal ganglion cell (RGC) types captured much of the v

127 Visual information is encoded in distinct retinal ganglion cell (RGC) types in the eye tuned to sp

128 to optically record optogenetically restored retinal ganglion cell activity in the fovea of the livin

129 ration, oligodendrocyte loss, and subsequent retinal ganglion cell death.

130 Intraocular pressure-sensitive retinal ganglion cell degeneration is a hallmark of glau

131 ongation in myopia to compensate for reduced retinal ganglion cell density.

132 is hard-wired in the machinery of vertebrate retinal ganglion cell genesis.

133 ociated with a loss of structural markers of retinal ganglion cell health in a multiethnic Asian popu

134 lamina-specific, and topographically ordered retinal ganglion cell synaptic inputs.

135 Retinal ganglion cells (RGCs) are a heterogeneous popula

136 We compared acutely isolated retinal ganglion cells (RGCs) at various developmental s

137 Using purified adult retinal ganglion cells (RGCs) in culture, we demonstrate

138 Pou5f1), Sox2 and Klf4 genes (OSK) in mouse retinal ganglion cells restores youthful DNA methylation

139 cells are one of the major types of primate retinal ganglion cells.

140 projections and concurrent transposition of retinal guidance cues into the superior colliculus provi

141 st that long-term photoreceptor survival and retinal health is in part reliant on melatonin orchestra

142 stress patterns consistent with the diffuse retinal hemorrhages (RH) typically found in the posterio

143 Six weeks later, retinal hemorrhages had substantially resolved, and ther

144 Retinal hemorrhages were categorized according to size-t

145 The present study implies that retinal hypovascularization can arise from a second and

146 It is driven by retinal hypoxia frequently caused by capillary nonperfus

147 tic fundus photography followed by automated retinal image analysis with human supervision.

148 Whenever the retinal image changes, some neurons in visual cortex inc

149 ze of objects varying with the size of their retinal image.

150 nes from information in two-dimensional (2D) retinal images.

151 orporating neuronal adaptation to stabilized retinal images.

152 A multispectral retinal imaging device obtained precise measurements of

153 ics, ophthalmologic examination results, and retinal imaging findings.

154 stalline bodies not identifiable using other retinal imaging techniques.

155 med to measure cardiac function indices, and retinal imaging was used to measure retinal vascular cal

156 We conducted multimodal retinal imaging, full-field electroretinography, and mol

157 t of best-corrected visual acuity (BCVA) and retinal imaging, including spectral-domain OCT (SD-OCT),

158 t continued close monitoring with multimodal retinal imaging.

159 and structural outcomes in animal models of retinal injury and retinal degenerative disease.

160 Here we investigate whether retinal inputs modulate entrainment to nonphotic cues su

161 ence of inferior retinal breaks and inferior retinal involvement in particular.

162 s model did not prevent capillary closure or retinal ischemia.

163 Retinal layer and fluid features were extracted using an

164 results indicate considerable differences in retinal layer structuring based on the severity of DR.

165 analysis, cone lipofuscin was found in outer retinal layers of 25% of healthy aged eyes.

166 l, ultrastructural constituents of the whole retinal layers, and the sequencing of shortwave length s

167 l pigment epithelium loss, and loss of outer retinal layers.

168 In Rlbp1/Cralbp(-/-) mice, reduced 11-cis-retinal levels, qAF and NIR-AF intensities, and photorec

169 Here we examine key characteristics of retinal macrophage cells in live human eyes, both health

170 nization of cortical V1 projections onto the retinal map (Savier et al., 2017).

171 Analysis of the retinal microvasculature in ORP2 knock-out mice generate

172 ions between indices of cardiac function and retinal microvasculature, adjusting for age, sex, body m

173 outcomes (visual acuity, lesion activity and retinal morphology) using correlation and machine learni

174 ophthalmoscopy, and histologic assessment of retinal morphology, we found that treatment with these f

175 GRK1-S21A mice had normal retinal morphology, without evidence of degeneration.

176 d receptor alpha (PPARalpha) is expressed in retinal Muller cells, endothelial cells, and in retinal

177 ction Fech(m1Pas) mutant mice showed reduced retinal neovascularization and endothelial cell prolifer

178 tion and chemical inhibition of Fech reduces retinal neovascularization and promotes physiological an

179 But FECH has not been explored in retinal neovascularization, which underlies diseases lik

180 The estimated proportion of peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion c

181 measured by the OCT rate of thinning of the retinal nerve fiber layer (RNFL) and ganglion cell-inner

182 p learning models were trained to use SD OCT retinal nerve fiber layer (RNFL) thickness maps, RNFL en

183 ange in the appearance of the optic nerve or retinal nerve fiber layer occurring before the imaging s

184 ace (P = .039), axial length (P = .033), and retinal nerve fiber layer thickness (P < .001) among the

185 y of glaucoma, visual field mean defect, and retinal nerve fiber layer thickness were not found to co

186 annualized rates of change in peripapillary retinal nerve fiber layer, ganglion cell plus inner plex

187 ed lipid metabolism as a contributor to this retinal neurodegenerative disease.

188 l, the data indicate potential mechanisms in retinal neurodevelopment of Dys(-/-) mice, which may hav

189 cells capable of regenerating all classes of retinal neurons and restoring visual function.

190 ferentiation of the photoreceptors and other retinal neurons by influencing the expression of target

191 l rh-NGF exhibits neuroprotective effects on retinal neurons via influencing secondary degeneration p

192 In some pairs of retinal neurons, called paramorphic, one member responds

193 tude should be accounted for when performing retinal OCTA evaluation of VD values.

194 narization is a critical step in analysis of retinal optical coherence tomography angiography (OCTA)

195 e of altered FAZ topography in patients with retinal or systemic disease could negatively impact the

196 revented the attrition of RGCs in developing retinal organoid cultures without compromising axon outg

197 ohistochemistry in murine cells, tissues, or retinal organotypic cultures, we report that a naphthoqu

198 demonstrated RIMS2 localization in the human retinal outer plexiform layer, Purkinje cells, and pancr

199 aging were performed in both eyes to measure retinal oxygen contents and total retinal blood flow, re

200 major retinal vessels and measured the total retinal oxygen metabolic rate in rats using visible-ligh

201 We conclude that this mechanism for retinal oxygenation played a vital role in the adaptive

202 Her9 homozygous mutants displayed striking retinal phenotypes, including decreased numbers of rods

203 ofluorescence (NIR-AF) provided evidence for retinal pigment epithelial cell (RPE) involvement.

204 screens in wild-type and TP53 knockout human retinal pigment epithelial cells using a focused dual gu

205 lity of dysbiotic Pg-strains to invade human-retinal pigment epithelial cells(ARPE-19), their surviva

206 iole number at the population level in human retinal pigment epithelial cells.

207 oid zone disruption), components of complete retinal pigment epithelium (RPE) and outer retinal atrop

208 ed using spectral-domain OCT with respect to retinal pigment epithelium (RPE) in 836 spectral-domain

209 The retinal pigment epithelium (RPE) is a highly polarized e

210 The retinal pigment epithelium (RPE) is a particularly vulne

211 Lipofuscin in the retinal pigment epithelium (RPE) is the major source of

212 fied negative regulator of the ER-associated retinal pigment epithelium (RPE)65 isomerase necessary f

213 the photoreceptor zone, ellipsoid zone, and retinal pigment epithelium (RPE, P < 0.001 and P = 0.005

214 The 2 biomarkers were RPE65 for retinal pigment epithelium and CD163 for histiocytes, ea

215 lesion perimeter (a measure of the number of retinal pigment epithelium cells exposed at the lesion b

216 Retinal pigment epithelium degeneration followed by reti

217 hypertransmission of light into the choroid, retinal pigment epithelium loss, and loss of outer retin

218 e retina, separating photoreceptors from the retinal pigment epithelium.

219 sociated with perturbed melanogenesis in the retinal pigment epithelium.

220 cted after semiautomatic segmentation of the retinal pigment epithelium/Bruch membrane complex.

221 the human visual system (retina, macula, and retinal pigment epithelium/choroid) reveals features of

222 inal Muller cells, endothelial cells, and in retinal pigment epithelium; agonism of PPARalpha with ge

223 and photoreceptor-specific markers in human retinal pigment epitheliums cells.

224 participation of lateral rim cells in a sub-retinal pigment shield in an insect eye.

225 copy, it was possible to reveal that the sub-retinal pigment shield of T. evanescens is not formed by

226 maintains therapeutic levels of sunitinib in retinal pigmented epithelium/choroid and retina for more

227 epresenting the presaccadic and postsaccadic retinal positions of the cue.

228 and neural retina to ensure adequate 11-cis-retinal production under natural illuminances that can s

229 RGCs differentiated in vitro from embryonic retinal progenitors for the effects of aging and, indepe

230 in the midbrain involving the mapping of the retinal projections and concurrent transposition of reti

231 w spatial resolution as generated by current retinal prostheses.

232 We link this effect to the rigidity of the retinal protein environment.

233 The retinal reattachment rate was 80.3%.

234 At 1 year, the retention probability of retinal reattachment was 0.84 (95% confidence interval,

235 al success was defined as the maintenance of retinal reattachment without any further surgery during

236 ging device obtained precise measurements of retinal reflectance over space and time.

237 om quiescence to reactivity is essential for retinal regeneration, whereas in mice, a dedicated netwo

238 The disease is confined mainly to a central retinal region called the MacTel zone.

239 usion was quantified using UWF-FA in defined retinal regions [posterior pole (PP), mid-periphery (MP)

240 Nearly all types are shared between the two retinal regions, but there are notable differences in ge

241 Four eyes for which primary retinal repair was done had redetachment (100% of operat

242 re controversial, and the pathophysiology of retinal research findings is still not clearly understoo

243 2) charge separation between the protonated retinal Schiff base (RSBH(+)) and its counterion complex

244 identified social cognitive determinants of retinal screening.

245 model was finally compared with that of non-retinal specialized ophthalmologists.

246 At these 3 private practice retinal specialty clinics, 41% of after-hours appointmen

247 consistent with neo-TADs leading to ectopic retinal-specific enhancer-GDPD1 accessibility.

248 properties of the physical environment from retinal stimulation is a distinct and more challenging c

249 lecule activator of PKM2, during acute outer retinal stress.

250 Retinal striae may be caused by the volume effect of the

251 therapeutic strategies will depend on inner retinal structural and functional preservation.

252 and describe re-treatment rates rather than retinal structural outcomes predictive of long-term visi

253 A 65-year-old male was referred for vitreo-retinal surgery with a provisional diagnosis of rhegmato

254 e lack of BBSome function negatively impacts retinal synaptogenesis, and causes horizontal cell defec

255 etinol acyltransferase (LRAT) disrupt 11-cis-retinal synthesis and cause Leber congenital amaurosis (

256 with proliferative vitreoretinopathy, giant retinal tears, previous invasive glaucoma surgery, and <

257 dissociate spontaneously into apo-opsin and retinal (the chromophore) without isomerization.

258 )65 isomerase necessary for recycling 11-cis-retinal, the light-sensitive chromophore of both rod and

259 t this dark band corresponds with an area of retinal thickening compared to adjacent areas.

260 ot identify significant associations between retinal thickness and motor deterioration.

261 Mean reductions in central retinal thickness from baseline were 126.1, 127.1, and 1

262 coherence tomography demonstrated decreased retinal thickness in chronic autoimmune uveitis mice, an

263 Central retinal thickness normalizes faster after surgery in eye

264 ed visual acuity, microperimetry and central retinal thickness.

265 bilistic model of cone cell decisions in the retinal tissue based on thyroid hormone signaling activi

266 Overall, we suggest that eye morphology and retinal topography in flamingos reflects their cathemera

267 dict future development of radiation-induced retinal toxicity.

268 a mining of human adult bulk and single-cell retinal transcriptional datasets revealed predominant ex

269 Furthermore, the 9-cis-retinal treatment decreased retinal apoptosis as shown b

270 ere reviewed by 2 authors for characteristic retinal vascular abnormalities.

271 dysfunction typically precedes the onset of retinal vascular and even some neurodegenerative disease

272 ces, and retinal imaging was used to measure retinal vascular caliber and retinal vascular geometric

273 Newer imaging technologies allow analysis of retinal vascular caliber beyond the standard areas surro

274 fected by anti-VEGF treatments, suggesting a retinal vascular contribution to the pathogenesis of AMD

275 ore the pathogenic basis of KIF11-associated retinal vascular disease, we generated a Kif11 condition

276 Using primary human retinal vascular endothelial cells and an established hu

277 The current study aims to investigate retinal vascular function and its relationship with syst

278 used to measure retinal vascular caliber and retinal vascular geometric indices.

279 We hypothesized that retinal vascular leakage would be associated with brain

280 previous anti-VEGF treatments did not impact retinal vascular measurements (P = .324-.986).

281 s, glaucoma, episcleritis and scleritis, and retinal vascular occlusion in patients with SLE deserves

282 Acute retinal vascular occlusions are common causes of visual

283 griseofulvin in adult mice does not disrupt retinal vasculature, function, or morphology.

284 P or its BMP4-binding capacity disrupted the retinal vasculature, resulting in poorly formed networks

285 found to show additional evidence of occult retinal vasculitis on FA.

286 ed cases of atezolizumab-associated AMN with retinal vasculitis.

287 Retinal VD is decreased in eyes with exudative AMD compa

288 d in the Study of Comparative Treatments for Retinal Vein Occlusion 2, and 88 participants randomized

289 Central retinal vein occlusion is a variable disease pattern.

290 on in the Standard Care vs Corticosteroid in Retinal Vein Occlusion Study.

291 with stroke expertise, whereas treatment of retinal vein occlusions is provided by ophthalmologists.

292 Peripapillary superficial retinal vessel densities were significantly reduced in p

293 others previously achieved oximetry on major retinal vessels and measured the total retinal oxygen me

294 re the cells preferentially recruited to the retinal vessels and protect vessels from diabetic damage

295 cally affects the vascular response in small retinal vessels in order to maintain hemodynamic regulat

296 hanges (e.g. decreased flow or occlusion) in retinal vessels may serve as a useful diagnostic indicat

297 e policy we quantified the pattern of vitreo-retinal (VR) diseases presenting at the national referra

298 formation extraction from RGC populations in retinal whole mounts to evaluate the changes in RGC size

299 Using stereology and retinal whole mounts, we estimate that the total number

300 genes was validated by immunofluorescence on retinal wholemounts and cryosections and by flow cytomet