ライフサイエンスコーパス: retinol

1 th minimal increases in preformed vitamin A (retinol).

2 (ranging from 1.00 for ascorbate to 1.05 for retinol).

3 pha-1-acid glycoprotein (AGP), ferritin, and retinol.

4 te and transported in the blood analogous to retinol.

5 lyzes the reduction of retinaldehyde back to retinol.

6 rved with 3,3-, 4,4-, and 3,3,4,4-deuterated retinol.

7 (control), both containing 1.8 muCi of [(3)H]retinol.

8 ns-retinol visual chromophore back to 11-cis-retinol.

9 ol to trigger release and internalization of retinol.

10 brospinal fluid transporter of thyroxine and retinol.

11 ene concentrations but did not improve serum retinol.

12 omerase in Muller cells, appears to be 9-cis retinol.

13 SDR9C7 is an enzyme to convert retinal into retinol.

14 the percentages of the explained variance of retinol.

15 ces the hydrophobic stabilization effects of retinol.

16 (0.74, 0.98)], NEO with a lower risk of low retinol [0.75 (0.62, 0.89)], and AAT with a lower risk o

17 sis depends on the influx of serum all-trans-retinol (1) delivered via a tertiary retinol binding pro

18 RBP4) serves as a transporter for all- trans-retinol (1) in the blood, and it has been proposed to ac

19 izemeal clusters (P < 0.001), but mean serum retinol (1.00 +/- 0.33 mumol/L overall) and deficiency p

20 alysis of the fat-soluble vitamins all-trans retinol (A), 25-hydroxyvitamin D2, 25-hydroxyvitamin D3,

21 not cause compensatory induction of lecithin:retinol acetyltransferase (Lrat) or retinol dehydrogenas

22 corbic acid, total phenols, carotenoids, and Retinol Activity Equivalent (RAE) were measured.

23 did not affect total carotenoids content and retinol activity equivalents (RAE) of juices whereas hom

24 Children consumed 221 and 74 ug/d retinol activity equivalents from intervention foods in

25 t a rich source of provitamin A (ca. 124 mug retinol-activity-equivalents/100g pulp, FW).

26 ns in retinoid isomerase (RPE65) or lecithin-retinol acyltransferase (LRAT) disrupt 11-cis-retinal sy

27 Mutations in RPE65 or lecithin-retinol acyltransferase (LRAT) disrupt 11-cis-retinal sy

28 lation level is highly regulated by lecithin:retinol acyltransferase (LRAT) enzyme.

29 on and colocalization of RPE65 with lecithin:retinol acyltransferase (LRAT) that provides the hydroph

30 crossing transgenic mice expressing lecithin retinol acyltransferase (Lrat)-driven Cre and maintained

31 oximately 2-fold higher vitamin A (all-trans-retinol (all-trans-ROL)) in the neural retina following

32 we have imaged the fluorescence of all-trans-retinol, all-trans-retinal, and lipofuscin precursors in

33 globulin averaged 1.57-6.75 times higher and retinol, alpha-tocopherol, and 25(OH)D 0.30-0.84 times l

34 ions of the concentrations of 7 carotenoids, retinol, alpha-tocopherol, and gamma-tocopherol with ris

35 id chromatography quantified serum levels of retinol, alpha-tocopherol, gamma-tocopherol and six caro

36 ene, lutein, zeaxanthin, beta-cryptoxanthin, retinol, alpha-tocopherol, gamma-tocopherol, and vitamin

37 ids were analyzed by gas chromatography, and retinol and alpha-, and gamma-tocopherol by liquid chrom

38 9c, 11tCLA, SigmaCLA, PUFA, omega3, omega6, retinol and alpha-tocopherol.

39 xisome biogenesis, fatty acid synthesis, and retinol and arachidonic acid metabolism.

40 ined the associations between maternal serum retinol and beta-carotene concentrations during late pre

41 Maternal serum retinol and beta-carotene concentrations had differing a

42 In late pregnancy, maternal serum retinol and beta-carotene concentrations were measured.

43 flammation, baseline serum concentrations of retinol and beta-carotene, and stratified design.

44 ing pairs had measurements of maternal serum retinol and beta-carotene, respectively.

45 results from observational studies of serum retinol and cancer risk have been mixed.

46 her investigation of the effects of maternal retinol and carotenoid status on offspring bone developm

47 ene from biofortified cassava improved serum retinol and hemoglobin concentrations modestly in Nigeri

48 to bind various bioactive molecules such as retinol and resveratrol, two ligands with different affi

49 d and converted to its bioactive derivatives retinol and retinoic acid by the intestinal epithelium,

50 We prospectively examined serum retinol and risk of overall and site-specific cancer in

51 We prospectively examined serum retinol and risk of overall and site-specific cancer in

52 ic protein transthyretin is a transporter of retinol and thyroxine in blood, cerebrospinal fluid, and

53 esized primarily in the liver where it binds retinol and transports it to tissues throughout the body

54 vitamin A status (retinol-binding protein or retinol)] and >/=1 biomarker of inflammation (alpha-1-ac

55 etinol to 3,4-dehydroretinol, 4-hydroxy (OH) retinol, and 3-OH retinol in a 100:3:2 ratio.

56 augmented proliferation and migration, lower retinol, and abolished retinoid X receptor/retinoid A re

57 with an increased risk of low ferritin, low retinol, and anemia.

58 all-trans and 11-cis isomers of retinal and retinol, and this facilitates their transport between ph

59 rmined differences in circulating ascorbate, retinol, and urate are not associated with differences i

60 vel PKCdelta signaling pathway that requires retinol as a metabolic cofactor and is involved in the r

61 ntified 63 metabolites associated with serum retinol below the Bonferroni-corrected P-value (p < 5.3

62 A decrease in serum retinol, beta-carotene, and RBP4 is associated with earl

63 levels were inversely correlated with serum retinol, beta-carotene, and RBP4.

64 and after the intervention to measure serum retinol, beta-carotene, C-reactive protein, and alpha1-a

65 d efficiently, causing repeated recycling of retinol between plasma and tissues (541 compared with 5

66 hemoglobin, ferritin, transferrin receptors, retinol binding protein (RBP), zinc, selenium, and vitam

67 loped an ON-switch system in which the human retinol binding protein 4 (hRBP4) of the lipocalin famil

68 Vitamin A bound to retinol binding protein 4 (RBP4) constitutes the major t

69 causes insulin resistance in human body and Retinol Binding Protein 4 (RBP4) is currently considered

70 In obesity and type 2 diabetes (T2D), retinol binding protein 4 (RBP4), the major retinol carr

71 l-trans-retinol (1) delivered via a tertiary retinol binding protein 4 (RBP4)-transthyretin (TTR)-ret

72 L-HDLs showed a reduced content of lipocalin retinol binding protein 4 and apolipoprotein M and in th

73 Here we examined the role of zebrafish retinol binding protein receptor 2 (Rbpr2) for RBP4-reti

74 s (ferritin, serum transferrin receptor, and retinol binding protein) in settings of prevalent inflam

75 d missense mutations in RBP4, encoding serum retinol binding protein, in three families with eye malf

76 luded height for age at 10 weeks, vitamin D, retinol binding protein, maternal education, household i

77 hout compromising the ability to predict the retinol binding site on RBP4 when adopting this proteoly

78 ty (ANS affinity) and higher conservation of retinol binding.

79 thus identifying free SAA as the predominant retinol-binding form in vivo.

80 This hydrophobic packing created a retinol-binding pocket in the center of the trimer, whic

81 5 ng/mL or 32 pmol/L), vitamin A deficiency (retinol-binding protein <14.7 mug/mL or 0.70 mumol/L) an

82 We crossed mice overexpressing human retinol-binding protein (hRBP) under the muscle creatine

83 have higher plasma ferritin (pF), and lower retinol-binding protein (RBP) and zinc (pZn) concentrati

84 Retinol-binding protein (RBP) is often used in populatio

85 Retinol-binding protein (RBP) is the sole specific carri

86 erum ferritin, soluble transferrin receptor, retinol-binding protein (RBP), 25-hydroxy vitamin D, fol

87 on retinyl esters (CM-REs), retinol bound to retinol-binding protein (RBP-ROH), and total retinol wer

88 orage, and metabolism of retinoids, cellular retinol-binding protein 1 (CRBP1) is essential for traff

89 in, and desmin, and negatively with cellular retinol-binding protein 1 and matrix metalloproteinase 2

90 eased markers of dedifferentiation, cellular retinol-binding protein 1, and matrix metalloproteinase

91 uced by immunization with interphotoreceptor retinol-binding protein 1177-1191 peptide were treated b

92 beta(2) -Microglobulin (beta(2) -m) and retinol-binding protein 4 (RBP4) are normally reabsorbed

93 escent protein (GFP), siderocalin (Scn), and retinol-binding protein 4 (RBP4) as model proteins and s

94 onsiderable evidence that both retinoids and retinol-binding protein 4 (RBP4) contribute to the devel

95 Retinol-binding protein 4 (RBP4) has been implicated as

96 Retinol-binding protein 4 (RBP4) serves as a transporter

97 -m), beta(2) -microglobulin (beta(2) -m) and retinol-binding protein 4 (RBP4) urine concentrations.

98 To examine whether serum retinol-binding protein 4 (RBP4), an endogenous TTR liga

99 Similarly, serum levels of retinol-binding protein 4 and retinoids were significant

100 bin concentration or serum concentrations of retinol-binding protein and prealbumin.

101 le transferrin receptor or vitamin A status (retinol-binding protein or retinol)] and >/=1 biomarker

102 usly quantifying iron (ferritin), vitamin A (retinol-binding protein), and inflammation (C-reactive p

103 n and serum concentrations of beta-carotene, retinol-binding protein, and prealbumin.

104 transportation of the hormone thyroxine and retinol-binding protein, in the myocardium.

105 retinoid-binding protein (IRBP) or cellular retinol-binding protein, suggesting that peropsin plays

106 Retinol-binding protein-4 (RBP4) is elevated in serum an

107 and the correlation between elevated urinary retinol-binding protein-urinary creatinine ratio (uRBP/u

108 ol), and proximal renal tubular dysfunction (retinol-binding protein/creatinine ratio >2.93mug/mmol a

109 it upon ligand binding by mammalian cellular retinol-binding proteins.

110 sfer of chylomicron retinyl esters (CM-REs), retinol bound to retinol-binding protein (RBP-ROH), and

111 We then determined the crystal structure of retinol-bound mouse SAA3 at a resolution of 2.2 angstrom

112 Retinol-bound SAA3 formed a novel asymmetric trimeric as

113 is reduced by exogenously applied all-trans retinol but not all-trans retinal.

114 ed associations of T2D and hypertension with retinol by linear regression and calculated the contribu

115 retinol binding protein 4 (RBP4), the major retinol carrier in serum, is elevated in AT and has proi

116 maternal status (all P < 0.05); ferritin and retinol changed by +2.0%; 95% CI: -8.9, 14.3%; P = 0.72;

117 shows that the oligomers formed from the BLG-retinol complex are smaller and more elongated compared

118 binding protein 4 (RBP4)-transthyretin (TTR)-retinol complex.

119 gonists that dissociate circulating RBP4-TTR-retinol complexes, reduce serum RBP4 levels, and inhibit

120 The baseline prevalence of serum retinol concentration <0.7 mumol/L and inflammation was

121 ed by ultra-high performance LC-MS/GC-MS and retinol concentration (from HPLC) using linear regressio

122 yellow cassava led to modest gains in serum retinol concentration and a large increase in beta-carot

123 bolite concentrations per unit difference in retinol concentration as standardized beta-coefficients

124 eta-carotene supplementation increased serum retinol concentration by 0.04 mumol/L (95% CI: 0.00, 0.0

125 effect of consuming yellow cassava on serum retinol concentration in Kenyan schoolchildren with marg

126 Serum retinol concentration is associated with circulating met

127 Serum retinol concentration was measured using reverse-phase h

128 Serum retinol concentration was measured using reverse-phase h

129 The primary outcome was serum retinol concentration; prespecified secondary outcomes w

130 The treatment effect on serum retinol concentrations at the end of the feeding trial w

131 Higher retinol concentrations were, however, associated with in

132 Higher retinol concentrations were, however, associated with in

133 0.124 umol/L), after adjustment for baseline retinol concentrations, inflammation, and asymptomatic m

134 fects hepatic glucose sensing independent of retinol conversion.

135 Our data show that kidneys respond to retinol deficiency by differential Stra6 promoter usage,

136 Gestational vitamin A (retinol) deficiency poses a risk for ocular birth defect

137 The protein has retinol dehydrogenase (RDH) activity, with enzymatic act

138 The microsomal retinol dehydrogenase (RDH11) and cytosolic soluble alde

139 Here, we sought to determine whether retinol dehydrogenase 10 (RDH10), upregulated in rod/con

140 of at least two subunits of NAD(+)-dependent retinol dehydrogenase 10 (RDH10), which catalyzes the ox

141 y, we discovered that mice with mutations in retinol dehydrogenase 10 (Rdh10), which perturbs Vitamin

142 B1 (Cyp26b1), which results in excess RA, or retinol dehydrogenase 10 (Rdh10), which results in RA de

143 lecithin:retinol acetyltransferase (Lrat) or retinol dehydrogenase 11 (Rdh11) mRNA or a decrease in a

144 binding cassette subfamily A member 4 (-/-) /retinol dehydrogenase 8 (-/-) and wild-type BALB/c mice

145 eport that two chromophore binding proteins, retinol dehydrogenase 8 (RDH8) and photoreceptor-specifi

146 Several enzymes exhibit retinol dehydrogenase activities in vitro; however, thei

147 These results indicate that the retinol dehydrogenase activities of murine SDR16C5 and S

148 onsistent with a nearly 80% reduction in the retinol dehydrogenase activities of skin membrane fracti

149 survival but are responsible for most of the retinol dehydrogenase activity in skin, essential for th

150 s shown with CRISPR/Cas9 knockout lines, the retinol dehydrogenase gene Rdh10 and a functional RARE i

151 release, all-trans-retinal is reduced by the retinol dehydrogenase RDH8 to all-trans-retinol in an NA

152 Here, we show that RGR opsin and retinol dehydrogenase-10 (Rdh10) convert all-trans-retin

153 esis at the rate-limiting step, catalyzed by retinol dehydrogenases (RDH).

154 aldehyde by alcohol dehydrogenases (ADHs) or retinol dehydrogenases (RDHs); and oxidation of retinald

155 Retinol dehydrogenases catalyze the rate-limiting step i

156 plished by a family of enzymes termed 11-cis-retinol dehydrogenases, including RDH5 and RDH11.

157 e present evidence that two murine epidermal retinol dehydrogenases, short-chain dehydrogenase/reduct

158 se results demonstrate that DGAT1 suppresses retinol-dependent Treg formation and suggest its potenti

159 sferrin saturation (depressed days 2-4), and retinol (depressed days 3, 4, and 7).

160 Retinoic acid (RA), a vitamin A (retinol) derivative, has pleiotropic functions during em

161 ional analytic methods do not separate alpha-retinol derivatives from active retinol.This study aimed

162 (Rdh10) convert all-trans-retinol to 11-cis-retinol during exposure to visible light.

163 tive retinol, suggesting that SAAs transport retinol during infection.

164 rediagnostic sera from the Beta-Carotene and Retinol Efficacy Trial (CARET) study.

165 tures with T cell-depleted lymphoid tissues, retinol enhanced Treg induction from DGAT1(-/-) but not

166 RA or retinol enhances 5hmC production in naive embryonic stem

167 e estimated total daily intake of vitamin A (retinol equivalents) and vitamin E (alpha-tocopherol equ

168 ations of choline, betaine, dimethylglycine, retinol, essential fatty acids, methionine, dimethylamin

169 ollowing a bleach and to use exogenous 9-cis retinol for pigment regeneration, suggesting that access

170 0 and transgenic rods were unable to use cis-retinol for pigment regeneration.

171 rotene was detected in the dairy samples but retinol (free or esterified), derived from the intake of

172 We found that IRBP removes all-trans-retinol from individual rod photoreceptors in a concentr

173 takes and serum concentrations of retinol (s-retinol) have been observed in epidemiologic studies.

174 droretinol, 4-hydroxy (OH) retinol, and 3-OH retinol in a 100:3:2 ratio.

175 e have decreased levels of retinoic acid and retinol in adipose tissue.

176 the retinol dehydrogenase RDH8 to all-trans-retinol in an NADPH-dependent reaction.

177 The aim is to investigate whether serum retinol in an un-supplemented state is associated with l

178 DGAT1 acyltransferase activity sequesters retinol in ester form, preventing synthesis of retinoic

179 Higher maternal serum retinol in late pregnancy was associated with lower offs

180 A higher risk of breast cancer was found for retinol in relation to ER-/progesterone receptor-negativ

181 ted in lower levels of all-trans-retinal and retinol in rod outer segments following light exposure.

182 be underestimated because of increased serum retinol in the context of kidney dysfunction.

183 The role of retinol in the prevention of multifactorial chronic dise

184 f all-trans-retinyl ester (atRE) into 11-cis-retinol in the retinal visual cycle.

185 class pathways were strongly associated with retinol, including amino acids (p = 1.6 x 10(-10)), lipi

186 have relevance to the biological actions of retinol, including its role in carcinogenesis.

187 by retinoic acid 6 (STRA6), which transports retinol into cells.

188 quires two enzymatic reactions: oxidation of retinol into retinaldehyde by alcohol dehydrogenases (AD

189 d (as compared with other fatty acids).alpha-Retinol is esterified in the enterocyte and transported

190 In the eye, uptake of RBP4-retinol is mediated by the receptor Stra6, whereas the r

191 zation of all-trans-retinyl esters to 11-cis-retinol is mediated by the retinoid isomerohydrolase Rpe

192 This 11-cis-retinol is oxidized selectively in cones to the 11-cis-r

193 zation of all-trans-retinyl esters to 11-cis-retinol, is also the isomerase enzyme responsible for th

194 e bleaching in rod photoreceptors, all-trans retinol, is part of a feedback loop that increases the s

195 eramide desaturase-1, the putative all-trans retinol isomerase in Muller cells, appears to be 9-cis r

196 Here, we evaluate the role of a candidate retinol isomerase of this pathway, sphingolipid delta4 d

197 e evolution of the BCO-related outlier RPE65 retinol isomerase, an enzyme that does not utilize carot

198 The retinol-isomerase activities of Rpe65 and Des1 are inhib

199 Retinol isotope dilution (RID) is a more sensitive techn

200 igh liver retinol stores determined by using retinol isotope dilution (RID).

201 d by mothers fed a VA-marginal diet (0.35 mg retinol/kg diet) and treated on postnatal day 4 with an

202 ly, Cyp1b1 could generate retinoic acid from retinol leading to cell-autonomous induction of the barr

203 on in males, whereas in autumn, it increased retinol levels but reduced coloration in both genders.

204 no significant differences in plasma RBP4 or retinol levels or in hepatic or adipose retinoid (retino

205 oup differences were found for vitamin B-12, retinol, linoleic acid (LA), alpha-linolenic acid (ALA),

206 In the presence of all-trans retinol, LRAT substrate, there is a significant decrease

207 pated (12.1% deficient on the basis of serum retinol <0.7 mumol/L).

208 ignificant inverse association between serum retinol, lycopene, and RBP4 concentrations with fibrosis

209 ay, which suggests the possibility that EtOH-retinol metabolic competition is one of the molecular me

210 ously associated with psoriasis risk such as retinol metabolism (Pcombined = 1.84 x 10(-4)), the tran

211 etabolism and downregulation of genes in the retinol metabolism in wild-type females compared with ER

212 ered activity of metabolic pathways, such as retinol metabolism, occurs downstream of ERalpha activat

213 e expression of two rate-limiting enzymes in retinol metabolism.

214 with ferritin (positive) and serum iron and retinol (negative, P < 0.05).

215 of vitamin A, niacin and riboflavin and milk retinol, nicotinamide, and free riboflavin concentration

216 concentrations of 25-hydroxyvitamin D and s-retinol on hip fracture was observed (P = 0.68).

217 es of this protein bound to either all-trans-retinol or retinylamine, the latter a therapeutic retino

218 have suggested that circulating carotenoids, retinol, or tocopherols may be associated with prostate

219 higher exposure to ascorbate, beta-carotene, retinol, or urate does not lower the risk of AD.

220 t in red and green rods, suggesting that cis retinol oxidation restricts access to the retina visual

221 drolase RPE65 (RPE65) and facilitates 11-cis-retinol oxidation to 11-cis-retinal.

222 Primary I148M HSCs showed reduced retinol (P < 0.001) but higher lipid droplet content (P

223 Vitamin A (all-trans retinol) plays critical roles in mammalian development a

224 Exogenous 9-cis retinol produced robust sensitivity recovery in bleached

225 We find that both ascorbate and RA or retinol promote the derivation of induced pluripotent st

226 indicating that the reduction of retinal to retinol promotes faster clearance of the photoisomerized

227 An attribute of the method is the use of retinol propionate, alpha-tocopheryl propionate and all-

228 mated the association between baseline serum retinol quintile (Q1-Q5) and overall and site-specific c

229 mated the association between baseline serum retinol quintile and overall and site-specific cancer ri

230 The retinol-RBP4 complex (holo-RBP) can be recognized by a c

231 zyme responsible for the oxidation of 11-cis-retinol remains unknown.

232 The rate constant for retinol removal increased linearly with IRBP concentrati

233 infection negatively impacts serum and liver retinol, rendering even well-nourished individuals susce

234 ad hypervitaminosis A defined as total liver retinol reserves >=1.0 mumol/g liver, which increased to

235 13C2-retinyl acetate to estimate total liver retinol reserves by RID with a follow-up 14-d blood samp

236 ments was equivalent to 22, 220, and 175 mug retinol, respectively.

237 ol levels or in hepatic or adipose retinoid (retinol, retinyl ester, and all-trans-retinoic acid) lev

238 retinal, followed by conversion to all-trans retinol (ROL) for removal from the photoreceptor.

239 bout the impact of obesity on vitamin A (VA)[retinol (ROL)], a nutrient that regulates expression of

240 The alcohol form of vitamin A (retinol/ROL) can be oxidized to all-trans-retinoic acid

241 at high intakes and serum concentrations of retinol (s-retinol) have been observed in epidemiologic

242 ere we illuminate a structural basis for the retinol-SAA interaction.

243 Here we show that the oxidoreductase retinol saturase (RetSat) is involved in the development

244 Here Heidenreich et al. show that retinol saturase is implicated in hepatic lipid metaboli

245 Analysis of the products of deuterated retinol showed a lack of scrambling of a putative allyli

246 e biomarkers were consistent with high liver retinol stores determined by using retinol isotope dilut

247 Retinol stores in the liver lasted for approximately 2 w

248 in association with the vitamin A derivative retinol, suggesting that SAAs transport retinol during i

249 We demonstrated in vitro and ex vivo that retinol supplementation enhances ATP synthesis in the pr

250 Vitamin A (VA; retinol) supplementation is used to reduce child mortali

251 results show that the retina produces 11-cis retinol that can be oxidized and used for pigment regene

252 This study explores the nature of the cis retinol that Muller cells in the retina provide to cones

253 c carrier in the bloodstream for hydrophobic retinol, the main form in which vitamin A is transported

254 Retinol, the most biologically active form of vitamin A,

255 Retinol, the most biologically active form of vitamin A,

256 parate alpha-retinol derivatives from active retinol.This study aimed to accurately characterize inte

257 sting a possible mode for internalization of retinol through direct diffusion into the lipid bilayer.

258 Oxidation of 11-cis-retinol to 11-cis-retinal is accomplished by a family of

259 l dehydrogenase-10 (Rdh10) convert all-trans-retinol to 11-cis-retinol during exposure to visible lig

260 P450 27C1 oxidized all-trans-retinol to 3,4-dehydroretinol, 4-hydroxy (OH) retinol, a

261 ID) is a more sensitive technique than serum retinol to measure VA status.

262 and are also essential for the oxidation of retinol to retinaldehyde in vivo Mice with targeted knoc

263 10 (RDH10), which catalyzes the oxidation of retinol to retinaldehyde, and two subunits of NADPH-depe

264 lular uptake of vitamin A by recognizing RBP-retinol to trigger release and internalization of retino

265 uated the associations of plasma carotenoid, retinol, tocopherol, and vitamin C concentrations and ri

266 evel and action are associated with impaired retinol transport and storage in adipose tissue in Lcn2

267 findings illuminate the molecular basis for retinol transport by SAA proteins during infection.

268 reas the receptor mediating RBP4 binding and retinol transport into the liver has just recently been

269 Coupled to retinol transport, holo-RBP can activate STRA6-driven Ja

270 The retinol transporter RBP4 was increased in adipose tissue

271 al, nonhepatic organs is limited.We examined retinol uptake and turnover in nonhepatic organs, includ

272 binding protein receptor 2 (Rbpr2) for RBP4-retinol uptake in developing embryos, using eye developm

273 results demonstrate that Rbpr2-mediated RBP4-retinol uptake in developing liver and intestine is nece

274 The protein levels of STRA6 responsible for retinol uptake were significantly decreased in adipose t

275 pr2 localized to membranes and promoted RBP4-retinol uptake.

276 We show that vitamin A (all-trans-retinol) (VA) is required both for the maintenance of pa

277 n which Muller cells recycle spent all-trans-retinol visual chromophore back to 11-cis-retinol.

278 ovitamin A carotenoid, is cleaved to produce retinol (vitamin A) and alpha-retinol (with negligible v

279 Here we report that retinoic acid (RA) or retinol (vitamin A) and ascorbate (vitamin C) act as mod

280 -ALDH pathway also governs the metabolism of retinol (vitamin A) to its transcriptionally active meta

281 lating ascorbate (vitamin C), beta-carotene, retinol (vitamin A), and urate.

282 y of retinaldehyde is further metabolized to retinol (vitamin A), esterified and packaged into triacy

283 Retinoic acid (RA), a metabolite of retinol (vitamin A), functions as a ligand for nuclear R

284 Neither 3-OH nor 4-OH retinol was an intermediate in desaturation.

285 ge prospective cohort analysis, higher serum retinol was associated with increased risk of prostate c

286 A greater risk of low retinol was associated with LMZ [1.24 (1.08, 1.45)].

287 e found that the majority of the circulating retinol was associated with the small fraction of SAA pr

288 In all subjects, a majority of alpha-retinol was esterified to palmitic acid (as compared wit

289 When retinol was included in the diet, it accumulated more in

290 Retinol was inversely associated with eGFR, although was

291 ith offspring bone size and growth at birth: retinol was negatively associated with these measurement

292 After multivariable adjustment, higher serum retinol was not associated with overall cancer risk (hig

293 After multivariable adjustment, higher serum retinol was not associated with overall cancer risk (Q5

294 retinol-binding protein (RBP-ROH), and total retinol were estimated in WinSAAM software.VA supplement

295 e, which may play a role in the retention of retinol when vitamin A is low.

296 Retinol, which has a high affinity for the BLG hydrophob

297 ved to produce retinol (vitamin A) and alpha-retinol (with negligible vitamin A activity).

298 sent study will produce sufficient all-trans retinol within the interphotoreceptor matrix to explain

299 tested in vivo if a persistent oversupply of retinol would further impair glucose metabolism in a mou

300 cohort we evaluated the risk of anemia, low retinol, zinc, and ferritin, and high transferrin recept