ライフサイエンスコーパス: retinol-binding protein

1 llular LBPs such as serum albumin and plasma retinol binding protein.

2 yx in a manner similar to retinol binding in retinol-binding protein.

3 ne tetramer of TTR can bind two molecules of retinol-binding protein.

4 bundant substrate: retinol bound to cellular retinol-binding protein.

5 Here we show that mouse and human SAAs are retinol binding proteins.

6 it upon ligand binding by mammalian cellular retinol-binding proteins.

7 hibitor families, as well as fatty acid- and retinol-binding proteins.

8 The cellular retinol-binding protein 1 (CRBP1) and the retinoic acid

9 orage, and metabolism of retinoids, cellular retinol-binding protein 1 (CRBP1) is essential for traff

10 A receptor beta2 (RARbeta2) and the cellular retinol-binding protein 1 (CRBP1).

11 romising therapeutic strategy, with cellular retinol-binding protein 1 (RBP1) emerging as a potential

12 in, and desmin, and negatively with cellular retinol-binding protein 1 and matrix metalloproteinase 2

13 on, retinol-related genes such as CRABP2 and retinol-binding protein 1 were overexpressed in WT, and

14 eased markers of dedifferentiation, cellular retinol-binding protein 1, and matrix metalloproteinase

15 enger RNA (mRNA) levels of LRAT and cellular retinol binding protein-1.

16 regulating RA-responsive genes like cellular retinol-binding protein-1.

17 uced by immunization with interphotoreceptor retinol-binding protein 1177-1191 peptide were treated b

18 loped an ON-switch system in which the human retinol binding protein 4 (hRBP4) of the lipocalin famil

19 ROL circulates in the blood bound to the retinol binding protein 4 (RBP4) as RBP4-ROL.

20 Vitamin A bound to retinol binding protein 4 (RBP4) constitutes the major t

21 are located near the transthyretin (TTR) and retinol binding protein 4 (RBP4) genes which encode majo

22 retinol (vitamin A) and its binding protein retinol binding protein 4 (RBP4) have been linked to pro

23 Retinol binding protein 4 (RBP4) is a serum protein that

24 causes insulin resistance in human body and Retinol Binding Protein 4 (RBP4) is currently considered

25 Nevertheless, retinol binding protein 4 (RBP4) is the only known carri

26 onally, 14 significantly lowers murine serum retinol binding protein 4 (RBP4) levels despite a lack o

27 lective increase in plasma and intra-adipose retinol binding protein 4 (RBP4) that preceded obesity.

28 sed in the vascular endothelial cells, while retinol binding protein 4 (rbp4) was expressed in the yo

29 In obesity and type 2 diabetes (T2D), retinol binding protein 4 (RBP4), the major retinol carr

30 l-trans-retinol (1) delivered via a tertiary retinol binding protein 4 (RBP4)-transthyretin (TTR)-ret

31 atocytes lipogenesis and HSCs activation via retinol binding protein 4 (Rbp4).

32 L-HDLs showed a reduced content of lipocalin retinol binding protein 4 and apolipoprotein M and in th

33 echanistic studies linking retinol and RBP4 (retinol binding protein 4) to the pathogenesis of cardio

34 stance have been found; a notable example is retinol binding protein 4.

35 erations in the vitamin A-transport proteins retinol-binding protein 4 (RBP4) and prealbumin.

36 B(2) -Microglobulin (B(2) -m) and retinol-binding protein 4 (RBP4) are normally reabsorbed

37 beta(2) -Microglobulin (beta(2) -m) and retinol-binding protein 4 (RBP4) are normally reabsorbed

38 escent protein (GFP), siderocalin (Scn), and retinol-binding protein 4 (RBP4) as model proteins and s

39 investigate the mechanisms by which elevated retinol-binding protein 4 (RBP4) causes insulin resistan

40 The increase of apo-/holo-retinol-binding protein 4 (RBP4) concentrations has been

41 Elevated levels of serum retinol-binding protein 4 (RBP4) contribute to insulin r

42 onsiderable evidence that both retinoids and retinol-binding protein 4 (RBP4) contribute to the devel

43 Retinol-binding protein 4 (RBP4) has been implicated as

44 Antagonists of retinol-binding protein 4 (RBP4) impede ocular uptake of

45 Retinol-binding protein 4 (RBP4) is the sole specific se

46 Serum retinol-binding protein 4 (RBP4) is the sole specific tr

47 Serum retinol-binding protein 4 (RBP4) is the sole specific vi

48 in (TTR) is a critical determinant of plasma retinol-binding protein 4 (RBP4) levels.

49 Retinol-binding protein 4 (RBP4) may play an important r

50 Retinol-binding protein 4 (RBP4) serves as a transporter

51 Retinol-binding protein 4 (RBP4) transports retinol from

52 (a(1) -m), B(2) -microglobulin (B(2) -m) and retinol-binding protein 4 (RBP4) urine concentrations.

53 -m), beta(2) -microglobulin (beta(2) -m) and retinol-binding protein 4 (RBP4) urine concentrations.

54 bition of the retinol-induced interaction of retinol-binding protein 4 (RBP4) with transthyretin (TTR

55 onizing the retinol-dependent interaction of retinol-binding protein 4 (RBP4) with transthyretin in t

56 Serum levels of retinol-binding protein 4 (RBP4), a protein secreted by

57 To examine whether serum retinol-binding protein 4 (RBP4), an endogenous TTR liga

58 etinol is not mobilized into circulation via retinol-binding protein 4 (RBP4), and genetic ablation o

59 Retinol-binding protein 4 (RBP4), the sole retinol trans

60 Similarly, serum levels of retinol-binding protein 4 and retinoids were significant

61 a genetic model of obesity, plasma levels of retinol-binding protein 4 were higher but bisretinoids i

62 adipocytokines (interleukin-6, adiponectin, retinol-binding protein 4) or soluble intercellular adhe

63 variate analysis) determinant of circulating retinol-binding protein 4, a reliable proxy for retinol

64 itively associated with albuminuria, urinary retinol-binding protein 4, LV mass, and type 2 diabetes

65 h a diet high in fat presented with elevated retinol-binding protein 4, the protein responsible for t

66 e show, using DNA arrays, that expression of retinol binding protein-4 (RBP4) is elevated in adipose

67 s of TNF-alpha, IL-6, adiponectin, resistin, retinol binding protein-4, or intraabdominal fat volume.

68 high-molecular-weight adiponectin, resistin, retinol binding protein-4, or intraabdominal obesity, su

69 Retinol-binding protein-4 (RBP4) is an emerging candidat

70 Retinol-binding protein-4 (RBP4) is elevated in serum an

71 factor B, haptoglobin, transthyretin, plasma retinol binding protein, albumin, and hemopexin.

72 our serum proteins-carcinoembryonic antigen, retinol binding protein, alpha1-antitrypsin, and squamou

73 the fatty acid binding proteins and cellular retinol binding protein also are down-regulated in the a

74 Cellular retinol binding protein and cellular retinoic acid bindi

75 bin concentration or serum concentrations of retinol-binding protein and prealbumin.

76 usly quantifying iron (ferritin), vitamin A (retinol-binding protein), and inflammation (C-reactive p

77 fetoprotein, apolipoproteins, transthyretin, retinol binding protein, and transferrin.

78 -reactive protein, alpha1-acid glycoprotein, retinol binding protein, and transthyretin.

79 n and serum concentrations of beta-carotene, retinol-binding protein, and prealbumin.

80 between tetrameric transthyretin, thyroxine, retinol-binding protein, and retinol.

81 m constitutive hepatic proteins (prealbumin, retinol-binding protein, and transferrin) increased with

82 annexins, transthyretins, nematode-specific retinol-binding proteins, and SCP/TAPS were identified.

83 enases (RoDH), which recognize holo-cellular retinol-binding protein as substrate, had been cloned, e

84 , malate dehydrogenase 1 cytoplasmic, plasma retinol-binding protein, biotinidase, and transferrin, a

85 ions with both unbound and CRBP(I) (cellular retinol-binding protein)-bound retinal, but apo-CRBP(I)

86 The metabolism of retinol-binding protein-bound all-trans-retinol, and alb

87 Km of approximately 0.7 microM, and cellular retinol-binding protein-bound retinal, with a Km of appr

88 esponse tests work on the principle that apo-retinol-binding protein builds up in the liver as liver

89 y using high-pressure liquid chromatography, retinol-binding protein by using ELISA, and alanine amin

90 The genes encoding serum retinol binding protein, cellular retinol binding protei

91 and serum amyloid-A and an increase in serum retinol-binding protein compared with placebo (p < .05).

92 nd provided with retinol or with the retinol/retinol-binding protein complex.

93 the transport of thyroxine and the vitamin A-retinol-binding protein complex.

94 serum RBP to an intracellular acceptor, the retinol-binding protein CRBP-I.

95 We showed earlier that cellular retinol-binding protein (CRBP) expression is downregulat

96 toward retinoids in the presence of cellular retinol-binding protein (CRBP) type I or cellular retina

97 e lipid-binding protein (KLBP), the cellular retinol-binding protein (CRBP), and the cellular retinoi

98 ic-acid-binding protein (CRABP) and cellular retinol-binding protein (CRBP), as well as their relatio

99 RA biosynthesis pathway consists of cellular retinol-binding protein (Crbp), retinol dehydrogenase (D

100 The physiologic role(s) of cellular retinol-binding protein (CRBP)-III, an intracellular ret

101 mbrane by an intracellular homolog, cellular retinol-binding protein (CRBP).

102 xploration of a beta-sheet protein, cellular retinol-binding protein (CRBP).

103 ses (RDHs), access retinol bound to cellular retinol-binding protein (CRBP).

104 Two cytoplasmic retinol-binding proteins, CRBP and CRBP II, and two cyto

105 ow that Rald is present in rodent fat, binds retinol-binding proteins (CRBP1, RBP4), inhibits adipoge

106 In vivo, retinoids are bound to cellular retinol-binding proteins (CRBPs) and cellular retinoic a

107 ol), and proximal renal tubular dysfunction (retinol-binding protein/creatinine ratio >2.93mug/mmol a

108 n causes distal bowel aganglionosis in serum retinol-binding-protein-deficient (Rbp4(-/-)) mice.

109 Ratios of serum retinol to retinol-binding protein did not deviate from 1.0, which

110 ein II (CRBP II) is a member of the cellular retinol-binding protein family, which is expressed prima

111 ate eyes acquires vitamin A from circulating retinol binding protein for chromophore biosynthesis.

112 Unliganded cellular retinol-binding protein has no effect on RoDH activity.

113 tamin A is transported in the blood bound to retinol-binding protein (holo-RBP), and its target cells

114 We crossed mice overexpressing human retinol-binding protein (hRBP) under the muscle creatine

115 ding serum retinol binding protein, cellular retinol binding protein I and cellular retinol binding p

116 Cellular retinol-binding protein I (CRBP I) and cellular retinol-

117 cyl chloromethyl ketone (AcDCMK) or cellular retinol-binding protein I (CRBP) diminished the generati

118 The levels of cellular retinol binding protein-I mRNA expression are not correl

119 Downregulation of the cellular retinol-binding protein-I (CRBP-I) occurs in breast and

120 e structure and dynamics of rat apo-cellular retinol binding protein II (apo-CRBP II) in solution has

121 protein cavity, we redesigned human cellular retinol binding protein II (hCRBPII) to fully encapsulat

122 cid increases the mRNA level of the cellular retinol binding protein II and the rate of retinol uptak

123 lular retinol binding protein I and cellular retinol binding protein II have been disrupted by homolo

124 ationally engineered protein (human cellular retinol binding protein II, hCRBPII) and different fluor

125 inol-binding protein I (CRBP I) and cellular retinol-binding protein II (CRBP II) are closely homolog

126 Cellular retinol-binding protein II (CRBP II) is a member of the

127 Cellular retinol-binding protein II (CRBPII), a cytosolic retinoi

128 e and backbone dynamics of rat holo cellular retinol-binding protein II (holo-CRBP II) in solution ha

129 a dimer of dimers, transports thyroxine and retinol binding protein in blood plasma and cerebrospina

130 fter CM-RE uptake, the levels of retinol and retinol-binding protein in serum, and retinoid levels in

131 mechanism for the uptake of retinol bound to retinol-binding protein in the small intestine of suckli

132 We have identified an intracellular retinol-binding protein in these tissues.

133 s (ferritin, serum transferrin receptor, and retinol binding protein) in settings of prevalent inflam

134 d missense mutations in RBP4, encoding serum retinol binding protein, in three families with eye malf

135 transportation of the hormone thyroxine and retinol-binding protein, in the myocardium.

136 is transported to and taken up by the eye by retinol-binding protein-independent and retinoic acid-re

137 the ability of M-TTR to form a complex with retinol binding protein, indicate that M-TTR forms a ter

138 we show that serum amyloid A (SAA) proteins retinol-binding proteins induced in intestinal epithelia

139 me oxygenase-1 (HO-1) and interphotoreceptor retinol binding protein (IRBP) were determined 1 to 2 da

140 heme oxygenase (HO)-1 and interphotoreceptor retinol binding protein (IRBP).

141 nder control of the human interphotoreceptor retinol-binding protein (IRBP) promoter.

142 5 ng/mL or 32 pmol/L), vitamin A deficiency (retinol-binding protein <14.7 mug/mL or 0.70 mumol/L) an

143 Hemoglobin, ferritin, retinol binding protein, malaria, and anthropometric mea

144 luded height for age at 10 weeks, vitamin D, retinol binding protein, maternal education, household i

145 <15 ng/mL for women), vitamin A deficiency (retinol-binding protein or retinol <20.1 ug/dL), inflamm

146 le transferrin receptor or vitamin A status (retinol-binding protein or retinol)] and >/=1 biomarker

147 uch as the transporter of thyroxine and holo retinol-binding protein or transthyretin (TTR) functioni

148 ons as the high-affinity receptor for plasma retinol binding protein (RBP) and mediates cellular upta

149 nitially assessed for vitamin A status using retinol binding protein (RBP) and modified relative dose

150 The interaction of HPR with retinol binding protein (RBP) and transthyretin was stud

151 Retinol binding protein (RBP) concentrations were determ

152 transports vitamin A from its blood carrier retinol binding protein (RBP) into cells, and it also fu

153 Urinary total protein, albumin, retinol binding protein (RBP), alpha-1-microglobulin, Ig

154 Plasma retinol, vitamin E, retinol binding protein (RBP), and C-reactive protein (C

155 s transported in the blood as a complex with retinol binding protein (RBP), but the molecular mechani

156 Serum retinol is transported by retinol binding protein (RBP), which has one high-affini

157 hemoglobin, ferritin, transferrin receptors, retinol binding protein (RBP), zinc, selenium, and vitam

158 ments of retinol, retinyl palmitate (RP), or retinol binding protein (RBP).

159 ular-weight proteins beta2-microglobulin and retinol binding protein (RBP)], although other measures

160 tinol, but there was a 7% increase in plasma retinol-binding protein (RBP) and a 56% reduction in vit

161 Retinol circulates in blood bound to retinol-binding protein (RBP) and is transported into ce

162 have higher plasma ferritin (pF), and lower retinol-binding protein (RBP) and zinc (pZn) concentrati

163 reported previously that mice lacking plasma retinol-binding protein (RBP) are phenotypically normal

164 Binding of the natural ligands thyroxine or retinol-binding protein (RBP) by Ser52Pro variant TTR st

165 Finally, by knocking out the retinol-binding protein (RBP) gene in the MCK-L0 backgro

166 The molten globule state of human serum retinol-binding protein (RBP) has been postulated previo

167 Mice lacking retinol-binding protein (RBP) have low circulating retin

168 ate uptake of retinol from its blood carrier retinol-binding protein (RBP) into cells and to function

169 Retinol-binding protein (RBP) is often used in populatio

170 Retinol-binding protein (RBP) is the sole specific carri

171 Retinol-binding protein (RBP) is the sole specific trans

172 Retinol-binding protein (RBP) was chosen as a surrogate

173 erum ferritin, soluble transferrin receptor, retinol-binding protein (RBP), 25-hydroxy vitamin D, fol

174 s, respectively: serum retinol, 90% and 78%; retinol-binding protein (RBP), 40% and 91%; retinol/RBP

175 aditional RDR test, could be circumvented if retinol-binding protein (RBP), a more stable marker of V

176 oss of CMOI function studies in mice lacking retinol-binding protein (RBP), an established model of e

177 Retinol-binding protein (RBP), an extracellular retinol

178 ombinant vitamin A serum transport proteins, retinol-binding protein (RBP), and transthyretin (TTR),

179 inol is transported around the body bound to retinol-binding protein (RBP), is transferred across the

180 Plasma retinol-binding protein (RBP), the principal carrier of

181 Dams lacking both LRAT and retinol-binding protein (RBP), the sole specific carrier

182 inol is transported in a 1-to-1 complex with retinol-binding protein (RBP).

183 transthyretin-associated transport protein, retinol-binding protein (RBP).

184 retinol and its specific transport protein, retinol-binding protein (RBP).

185 e target cells as all-trans-retinol bound to retinol-binding protein (RBP).

186 e basal surface of the cultured RPE by serum retinol-binding protein (RBP).

187 min A, retinol, circulates in blood bound to retinol-binding protein (RBP).

188 ular stores and circulates in blood bound to retinol-binding protein (RBP).

189 molecule metabolically interacting with TTR [retinol-binding protein (RBP)], for possible association

190 on retinyl esters (CM-REs), retinol bound to retinol-binding protein (RBP-ROH), and total retinol wer

191 revents inhibition by the cytosolic cellular retinol-binding protein (RBP1).

192 etinoid-binding protein (IRBP, also known as retinol-binding protein, RBP3), which enables the physic

193 f mice with a pNO(2)Phe(43) mutant of murine retinol-binding protein (RBP4) also elicited a high tite

194 STRA6, a high-affinity receptor for retinol-binding protein (RBP4), mediates vitamin A uptak

195 and secreted into circulation bound to serum retinol-binding protein (RBP4).

196 The Stra6 protein binds the serum retinol-binding protein, RBP4, and acts in conjunction w

197 of the lipophilic vitamin is mediated by the retinol-binding protein, RBP4.

198 Here we examined the role of zebrafish retinol binding protein receptor 2 (Rbpr2) for RBP4-reti

199 Our aim was to elucidate the role of the retinol-binding protein receptor STRA6, mediating cellul

200 gment biosynthesis in mice deficient for the retinol-binding protein receptor STRA6.

201 ncreased expression of the gene encoding the retinol-binding protein receptor Stra6L, which, in turn,

202 ascade, suppressed CRBP-I/RARalpha (cellular retinol-binding protein/retinoic acid receptor alpha) ex

203 entify SAAs as a family of microbe-inducible retinol binding proteins, reveal a unique protein archit

204 id (P-MMA), plasma folate (P-Fol), and serum retinol-binding protein (S-RBP) were measured at inclusi

205 media did not result from increased retinol-retinol-binding protein secretion but was dependent on t

206 least one retinoid binding protein (cellular retinol binding protein) serves as a retinoid concentrat

207 beta-Lg is a lipocalin, like plasma retinol-binding protein, so that ligand association was

208 However, the addition of retinol binding proteins stimulates 11-cis-retinol forma

209 retinoid-binding protein (IRBP) or cellular retinol-binding protein, suggesting that peropsin plays

210 Study of adipocyte retinol-binding protein synthesis and secretion indicate

211 binding protein (CRBP)-III, an intracellular retinol-binding protein that is expressed solely in hear

212 (beta2-microglobulin to creatinine ratio and retinol-binding protein to creatinine ratio) improved or

213 nstitutive serum protein levels (prealbumin, retinol binding protein, transferrin) and decreased seru

214 riptionally up-regulated by RA, the cellular retinol binding protein type I (CRBPI) and the RA recept

215 sts in a bound form, complexed with cellular retinol binding protein type I (holo-CRBP).

216 by the enterocyte is complexed with cellular retinol-binding protein type 2 and the complex serves as

217 Here we show that cellular retinol-binding protein type I (CRBP-I), a small cytosol

218 etinol oxidation in the presence of cellular retinol-binding protein type I (CRBPI) than human micros

219 Cellular retinol-binding protein type I (CrbpI), encoded by Rpb1,

220 esence of a 10-fold molar excess of cellular retinol-binding protein type I, which is believed to seq

221 9cRA)-inducible enhancer of the rat cellular retinol-binding protein type II gene (CRBP II) was shown

222 ulation (3-4-fold) in the level of cytosolic retinol-binding protein type III (CRBPIII) in adipose ti

223 All-trans-retinol bound to cellular retinol-binding protein (type I) exhibits a similar Ki v

224 vitamin A, i.e., retinol bound with cellular retinol binding-protein, type I.

225 Cellular retinol-binding protein, type 1 (CRBP1), encoded by reti

226 -binding protein, type I (CrbpI), encoded by retinol-binding protein, type 1 (Rbp1), is a chaperone o

227 -binding protein, type 1 (CRBP1), encoded by retinol-binding protein, type 1 (Rbp1), regulates RA hom

228 Rdh10 behaves similarly to cellular retinol-binding protein, type 1, which also localizes to

229 ate available physiologically, holo-cellular retinol-binding protein, type I (CRBP).

230 Cellular retinol-binding protein, type I (CRBP-I) and type II (CR

231 Cellular retinol-binding protein, type I (CrbpI), encoded by reti

232 Our data also establish that cellular retinol-binding protein, type II (CRBPII), which is expr

233 ntified a novel FABP family member, cellular retinol-binding protein, type III.

234 Cellular retinol-binding proteins types I and II (CRBP-I and CRBP

235 and the correlation between elevated urinary retinol-binding protein-urinary creatinine ratio (uRBP/u

236 friendly approaches are hemoglobin (anemia), retinol-binding protein (vitamin A), and iron (transferr

237 At least 70 genes control retinol-binding protein, vitamin A, and L-thyroxine leve

238 toichiometry of three interacting molecules, retinol-binding protein, vitamin A, and L-thyroxine, not

239 amer and binds the hormone thyroxine and the retinol-binding protein-vitamin A complex.

240 A possible role for C8 gamma as a retinol binding protein was also investigated.

241 Because RBP4 is a retinol-binding protein, we investigated whether these e

242 reception in mice, animals mutated in plasma retinol binding protein were placed on a vitamin A-free

243 es either in plasma TTR or in CSF and plasma retinol-binding protein were detected.

244 therefore represents a novel class of small retinol-binding protein, which appears to be confined to