ライフサイエンスコーパス: retinoschisis

1 n impairment in young males, called X-linked retinoschisis.

2 etinal hole, and typical degenerative senile retinoschisis.

3 as devoid of MG rip apart, a defect known as retinoschisis.

4 nal thickness decreases with age in X-linked retinoschisis.

5 P4 experienced an exacerbation of peripheral retinoschisis.

6 topsia, PAX6-related dystrophy, and X-linked retinoschisis.

7 come from a recent investigation in X-linked retinoschisis, a currently untreatable retinopathy.

8 s mutated, as it occurs in X-linked juvenile retinoschisis, a disease that results in morphological a

9 nked retinoschisis gene (RS1) cause X-linked retinoschisis, a form of progressive blindness.

10 riteria included a family history of macular retinoschisis, a known genetic abnormality associated wi

11 , we investigated a mouse model for X-linked retinoschisis, a well defined monogenic degenerative dis

12 e studied a mouse model of X-linked juvenile retinoschisis, an early-onset inherited condition caused

13 Most cases of X-linked juvenile retinoschisis and degenerative retinoschisis never requi

14 eted protein implicated in X-linked juvenile retinoschisis and essential for the structural and funct

15 uch as macular Berlin's edema, midperipheral retinoschisis, and choroidal and retinal detachment migh

16 e total area of the fibrous membranes, total retinoschisis, and detachment areas were significantly h

17 lattice retinal tears and detachments (RDs), retinoschisis, and fluorescein findings.

18 choroidal melanoma; and intraretinal edema, retinoschisis, and retinal thinning overlying irradiated

19 volvement of the fovea or enlargement of the retinoschisis area.

20 of primary retinal detachment (RD) repair in retinoschisis-associated RD (RSRD) and rhegmatogenous RD

21 tosa, Leber's congenital amaurosis, X-linked retinoschisis, Best's disease, Stargardt's disease, and

22 Midperipheral retinoschisis can additionally be complicated by a midpe

23 Midperipheral retinoschisis can progress to SNIFR over multiple years

24 e discovery that retinal folds and traumatic retinoschisis can very rarely occur after crush head inj

25 ellate nonhereditary idiopathic foveomacular retinoschisis contiguous with MPRS partially regressed a

26 Genetic testing for Congenital X-linked retinoschisis (CXLR) was negative.

27 otal area of the fibrous membranes and total retinoschisis-detachment area were found to be higher in

28 Presence of retinoschisis did not significantly increase risk of pri

29 ERG waveform that is characteristic of human retinoschisis disease and that implicates a synaptic tra

30 This new locus (RP23) encompasses the retinoschisis disease gene; therefore, XLRS1 was screene

31 Congenital X-linked retinoschisis displayed long-term stability in 83% of ey

32 he coding region of the gene responsible for retinoschisis do not cause RP23.

33 Midperipheral retinoschisis exhibited centripetal progression to SNIFR

34 These changes include retinoschisis, foveal retinal detachment, and lamellar o

35 , loss-of-function mutations in the X-linked retinoschisis gene (RS1) cause X-linked retinoschisis, a

36 was amplified with primers specific for the retinoschisis gene (XLRS1), and the products were screen

37 holog (Xlrs1) of the human X-linked juvenile retinoschisis gene (XLRS1).

38 nine hydroxylase, paired box 6, the X-linked retinoschisis gene and TSC2/tuberin.

39 ulitis, whereas congenital disorders such as retinoschisis had the worst.

40 30.6%), RDs in 140 eyes (38.6 %), tractional retinoschisis in 44 eyes (11.9%), and visible vitreous c

41 therapy will benefit patients with X-linked retinoschisis in a forthcoming clinical trial.

42 oma with a focal pit associated with macular retinoschisis in the other eye.

43 al coherence tomography revealed a FTMH with retinoschisis in the right eye and another FTMH in the l

44 -photoreceptor phenotype similar to X-linked retinoschisis in young males.

45 ings feature residues implicated in X-linked retinoschisis, indicating the importance of correct asse

46 erlying the lesion (39% vs. 61%; P = 0.003), retinoschisis involving the foveola (0% vs. 100%; P = 0.

47 r retinoschisis (ORS), with or without inner retinoschisis (IRS), and foveal detachment (FD) were ana

48 Thus, X-linked retinoschisis is caused by abnormalities in a putative s

49 X-linked retinoschisis is characterized by microcystic-like chang

50 opathy with exudative retinal detachment and retinoschisis-is rarely described.

51 treomacular traction syndrome, macular hole, retinoschisis, macular edema, central serous chorioretin

52 An X-linked retinoschisis mouse (Rs1h-KO) model was created by subst

53 series of glaucomatous patients with macular retinoschisis (MR) and/or serous retinal detachment (SRD

54 Macular retinoschisis (MRS) and myopic macular neovascularizatio

55 a known genetic abnormality associated with retinoschisis, myopic traction maculopathy, epiretinal m

56 nked juvenile retinoschisis and degenerative retinoschisis never require any type of surgical interve

57 hese conditions included progressive bullous retinoschisis, non-clearing vitreous hemorrhage, rhegmat

58 l fluid, pigment epithelial detachments, and retinoschisis on optical coherence tomography.

59 ore, our data suggest that X-linked juvenile retinoschisis originates from abnormalities in a photore

60 esence of a foveal involvement, and/or outer retinoschisis (ORS), with or without inner retinoschisis

61 ss and volume measurements were increased in retinoschisis patients compared to controls.

62 ss and volume measurements were decreased in retinoschisis patients compared to controls.

63 s and volumes were consistently increased in retinoschisis patients relative to controls.

64 The mean age of the retinoschisis patients was 26.4 years.

65 Foveal schisis was observed in 81% of retinoschisis patients.

66 inal detachment, typical degenerative senile retinoschisis, peripheral laser coagulation scars, ora t

67 actors can contribute to the severity of the retinoschisis phenotype.

68 Inner retinoschisis, present in 18 eyes (46%), resolved in all

69 X-linked retinoschisis results in visual loss in early life with

70 isk factor for the development of a combined retinoschisis-retinal detachment and may benefit from cl

71 otal of 7.5% of eyes demonstrated a combined retinoschisis-retinal detachment requiring surgery (n =

72 (n = 4) converted from type 3 to a combined retinoschisis-retinal detachment with mean time to conve

73 Eyes that initially demonstrated combined retinoschisis-retinal detachments and those with large,

74 5 years of age underwent genotyping, and the retinoschisis (RS1) mutations were classified as less se

75 ellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR) is a relatively recent and rare cl

76 l and choroidal thinning in 13 eyes (86.7%), retinoschisis temporal to the fovea in 2 eyes (13.4%), a

77 matopsia, retinitis pigmentosa, and X-linked retinoschisis), the bleeding disorder hemophilia, and ly

78 horoidal neovascularization, inner and outer retinoschisis, vitreous status) at baseline and at the f

79 Presence of retinoschisis was associated with worse final VA (beta 0

80 A macular retinoschisis was detected in 5 eyes (31%), decreased el

81 ual improvement or resolution of the macular retinoschisis was observed in eyes with medical or surgi

82 three eyes of 33 male patients with X-linked retinoschisis were gleaned from a SD OCT database at the

83 ructural features of human X-linked juvenile retinoschisis with dissection through, and disorganizati

84 ellate nonhereditary idiopathic foveomacular retinoschisis with MPRS can also spontaneously resolve o

85 ble option in the treatment of patients with retinoschisis without causing significant cellular damag

86 hy (SD-OCT) of the left eye revealed macular retinoschisis, without serous detachment.

87 family (a total of 18 members)with X-linked retinoschisis (XLRS) and detected a novel mutations of c

88 istent with human clinical X-linked juvenile retinoschisis (XLRS) in showing schisis cavities, which

89 X-linked retinoschisis (XLRS) is a form of macular degeneration w

90 X-linked juvenile retinoschisis (XLRS) is an early-onset inherited conditi

91 X-linked retinoschisis (XLRS) is an inherited form of macular deg

92 X-linked juvenile retinoschisis (XLRS) is an inherited retinal disease cau

93 The human retinal synaptic disease X-linked retinoschisis (XLRS) is characterized by impaired visual

94 X-linked Retinoschisis (XLRS) is one of the most common macular d

95 e cone system typically observed in X-linked retinoschisis (XLRS) represents a relatively greater def

96 Individuals with X-linked retinoschisis (XLRS) show a comparatively greater reduct

97 oschisin gene, RS-1, cause juvenile X-linked retinoschisis (XLRS), a dystrophy characterized by delam

98 at encode retinoschisin (RS1) cause X-linked retinoschisis (XLRS), a form of juvenile macular and ret

99 ions in the RS1 gene cause X-linked juvenile retinoschisis (XLRS), a hereditary retinal dystrophy.

100 X-linked juvenile retinoschisis (XLRS), a leading cause of juvenile macula

101 architecture with mutations causing X-linked retinoschisis (XLRS), a monogenic form of macular degene

102 enty-two adults and 5 children with X-linked retinoschisis (XLRS), aged 10 to 79 years, were enrolled

103 tations in the NR2E3 gene, juvenile X-linked retinoschisis (XLRS), and some other retinal dystrophies

104 form of macular degeneration called X-linked retinoschisis (XLRS).

105 cula, are not well characterized in X-linked retinoschisis (XLRS).