ライフサイエンスコーパス: retrovirally

1 nd network integration in a model of TLE, we retrovirally birthdated either early-born [EB; postnatal

2 We now demonstrate by retrovirally complementing STAT5ab(null/null) primary ma

3 mal DNA double strand breaks than were their retrovirally corrected counterparts.

4 Thus, retrovirally delivered mRNA may serve as an immediate tr

5 Moreover, using sustained, retrovirally delivered short hairpin RNA (shRNA) Axl kno

6 this, suppression of GRAIL expression using retrovirally delivered siRNA prevented the development o

7 , suppression of expression of Jagged2 using retrovirally delivered small interfering RNA failed to a

8 Deletion of the retrovirally-derived promoter portion abolished its acti

9 n families is associated with leukemias, and retrovirally driven coexpression of HOXA9 and MEIS1 is s

10 Retrovirally driven expression of either the CBP fragmen

11 th autologous bone marrow cells expressing a retrovirally encoded allogeneic MHC class I Ag results i

12 Expression of a retrovirally encoded allogeneic MHC class I gene in bone

13 progenitors inhibits induction of endogenous retrovirally encoded genes SYNCYTIN1/endogenous retrovir

14 s could be curbed via enforced expression of retrovirally encoded Pax5.

15 idity was despite variable expression of the retrovirally encoded TCR and the presence of potentially

16 urthermore, we found that T cells expressing retrovirally encoded TCR had avidity that was similar to

17 with N-ras coupling Eomes to T cell memory, retrovirally enforced expression of Eomes in N-ras-defic

18 Using adipocytes retrovirally engineered from murine embryonic fibroblast

19 mpacts critical quality attributes (CQAs) of retrovirally engineered T cell products.

20 ing a low risk of insertional oncogenesis in retrovirally engineered T cell therapies.

21 urthermore, bone marrow progenitors that are retrovirally engineered to express Cdx4 serially replate

22 1c(-/-) v-abl kinase-transformed pro-B cells retrovirally engineered with a construct that allows qua

23 MEK5-ERK5 pathway in T-cell development, we retrovirally expressed dominant-negative or constitutive

24 utilizing primary baby rat kidney cells and retrovirally expressed E1A, the ability of E1A to induce

25 at least 2 distinct mechanisms of silencing retrovirally expressed genes in hematopoietic cells.

26 t that GLI2 directly activates GLI1 and that retrovirally expressed GLI2 induces expression of endoge

27 , but surviving Purkinje cells contained the retrovirally expressed human enzyme, and transplanted an

28 , Pax3, Pax3-FKHR, and selected mutants were retrovirally expressed in NIH 3T3 cells and evaluated fo

29 Here, we retrovirally expressed N-Ras(G12D) in AE-expressing huma

30 e use a novel cell-based system to show that retrovirally expressed Pax-5 protein activates endogenou

31 o generate the fusion protein DD-MLL-ENL and retrovirally expressed the protein switch in human CD34+

32 To this end, we retrovirally expressed various beta3 integrins with cyto

33 Retrovirally expressed YB-1 binds to the cap of mRNAs an

34 To address this issue we retrovirally expressed, in bone marrow-derived macrophag

35 Retrovirally expressed, wild-type BRCA1 decreased the ga

36 stituting mice with hematopoietic stem cells retrovirally expressing these proteins.

37 stimulated B-cell blasts, both of which were retrovirally gene-transferred with an immunodominant pep

38 oplasia, for example in Ewing's sarcomas and retrovirally induced cancers.

39 We initially treated mice with retrovirally induced CML-like disease with imatinib plus

40 Moreover, retrovirally induced expression of Jagged2 did not enhan

41 tissue engineering, expression of hTERT was retrovirally induced in SMC from eight elderly patients

42 ased DNMT3B expression prolonged survival in retrovirally induced Myc-Bcl2- or MLL-AF9-driven leukemi

43 ides an overview of the role of ETS genes in retrovirally induced neoplasia, their possible mechanism

44 of tumor cells, particularly those that are retrovirally induced.

45 Moreover, clonal analyses of retrovirally infected cells incorporated within any part

46 In addition, retrovirally infected ES cells showed detectable express

47 To interfere with endogenous MCSP, we retrovirally infected keratinocytes with a chimera of th

48 In retrovirally infected mouse bone marrow cells, expressio

49 In retrovirally infected mouse marrow cells, the BCR/ABL mu

50 his, we first used a mouse mammary cell line retrovirally infected to express human PDK1 or Akt1 for

51 K562 leukemia cells retrovirally infected to overexpress P-gp are also resis

52 ssed endogenous wild-type (wt) EGFR, and two retrovirally infected U87MG cell populations which over-

53 The phenotype of the transfected, or retrovirally infected, cells was profoundly altered from

54 bladder tumor cell line, 5637, as well as in retrovirally infected, Rb(+) clones derived therefrom.

55 Between P6 and P45, retrovirally-infected EGFP(+) of progenitors migrated in

56 Introduction of Pax6 retrovirally into bone marrow macrophages attenuates RAN

57 To induce mammary tumors, we retrovirally introduced an oncogene, HRAS(G12V), into In

58 retroviral injection and the production of a retrovirally labeled "founder" cell; thus, we estimate t

59 tically characterized synaptic plasticity of retrovirally labeled adult-born dentate granule cells at

60 sed the proportion of ChAT-positive cells in retrovirally labeled clones to the same extent as IFN it

61 Closer inspection of retrovirally labeled neurons revealed microglia fused to

62 Consistently, patch-clamp recordings from retrovirally labeled new granule cells at 7-8 days post

63 Lac-Z), and ChAT-positive descendants of the retrovirally labeled precursors were counted.

64 romodeoxyuridine uptake and the expansion of retrovirally labeled progenitor clones, are mimicked by

65 the second part of this study, we show that retrovirally labeled radial astrocytes give rise to gran

66 r cortical lesions, disproportionately fewer retrovirally-labeled cells had migrated to the olfactory

67 weeks after cortical injury, the majority of retrovirally-labeled cells in both groups of mice had mi

68 At 3 weeks, we still observed retrovirally-labeled glial cells in the corpus callosum

69 In vivo two-photon imaging of retrovirally labelled adult-born JGNs reveals that ~90%

70 Baboon CD34-enriched marrow cells were retrovirally marked and infused into the irradiated babo

71 We previously reported that retrovirally marked clones in the mature chick diencepha

72 t of busulfan on contributions of individual retrovirally marked clones to hematopoiesis.

73 Retrovirally marked clones were found to contain neurons

74 nulocyte-colony-stimulating factor-mobilized retrovirally marked hematopoietic cells.

75 Although the retrovirally marked lymphocytes could be detected for mu

76 Naive or memory OT-1 CD8(+) T cells, retrovirally marked with the sr39TK gene, were adoptivel

77 We have previously established that retrovirally mediated delivery of angiotensin II type 1

78 e I receptor antisense (AT(1)R-AS) cDNA by a retrovirally mediated delivery system prevents the devel

79 essant drugs cyclosporin A and FK506, or the retrovirally mediated ectopic expression of a specific c

80 Retrovirally mediated expression of a mutant active beta

81 liferating resident macrophages, as shown by retrovirally mediated expression of GFP.

82 Retrovirally mediated expression of human papillomavirus

83 p53 function was suppressed by retrovirally mediated expression of the human papillomav

84 Our previous studies demonstrated that retrovirally mediated expression of the versican V3 spli

85 Our previous studies demonstrated that retrovirally mediated expression of the versican V3 spli

86 Retrovirally mediated functional genomics enables identi

87 s and B cell Ag presentation, we developed a retrovirally mediated gene expression approach for treat

88 Ex vivo retrovirally mediated gene therapy has been shown within

89 the cranial neural tube and neural crest by retrovirally mediated gene transfer resulted in a signif

90 Susceptibility of cultured FH to retrovirally mediated gene transfer was studied using an

91 nance of the immune privilege of the retina, retrovirally mediated gene transfer was used to express

92 from three rhesus macaques were subjected to retrovirally mediated gene transfer with a vector expres

93 f matrix metalloproteinase-I (TIMP-1), using retrovirally mediated gene transfer, and characterized t

94 ative mutant of GRK2 (DN-GRK2), K220R, using retrovirally mediated gene transfer, and we assessed fun

95 ation of viral receptors can greatly enhance retrovirally mediated gene transfer, DNA synthesis remai

96 a variety of leukemias and lymphomas due to retrovirally mediated insertional activation of cellular

97 solution using two complementary approaches: retrovirally mediated multiplex clonal analysis and sing

98 ls, both statin treatment of the T cells and retrovirally mediated overexpression of KLF2 in the T ce

99 Retrovirally mediated S1P(1) overexpression is sufficien

100 This is reinforced by our findings that retrovirally mediated stable transduction of PDX1 in pri

101 Retrovirally mediated transmission of mVL30 RNA to human

102 Migration of transduced (retrovirally mediated) fibroblasts was determined by cou

103 In fact, retrovirally mediated, Sox10-independent Mitf expression

104 Retrovirally-mediated constitutive expression of S1PR3 l

105 of IBC (MARY-X), we have demonstrated using retrovirally-mediated dominant-negative E-cadherin mutan

106 nhancer-of-split homologues) was examined by retrovirally misexpressing the constitutively active for

107 The T-cell stimulatory capacity of retrovirally modified and purified mCD2-positive allogen

108 ws engraftment with an encouraging number of retrovirally modified cells.

109 Retrovirally overexpressed GATA-3 has been reported to i

110 Retrovirally overexpressed Hlx also induced the aberrant

111 When ephrin-A2 is retrovirally overexpressed in the cerebellum, the olivoc

112 We aimed to test this hypothesis by retrovirally overexpressing the candidate enzyme MMP-9 i

113 These cell samples take advantage of retrovirally TCR-transduced T cells spiked into autologo

114 Therefore, we attempted to retrovirally transduce human DCs with a melanoma TAA gen

115 ic bone marrow cells engineered to express a retrovirally transduced allogeneic major histocompatibil

116 olecular chimeras requires expression of the retrovirally transduced allogeneic MHC Ag on the surface

117 his work we examined whether expression of a retrovirally transduced allogeneic MHC class I gene in b

118 e efficient transduction and expression of a retrovirally transduced alphaGT gene in bone marrow-deri

119 osteoclastogenesis in beta(3)(-/-) cells, we retrovirally transduced authentic osteoclast precursors

120 These studies have demonstrated that retrovirally transduced autoantigen-specific CD4+ T cell

121 Three baboons were conditioned with retrovirally transduced autologous bone marrow to induce

122 no curative treatments presently available, retrovirally transduced autologous epidermal grafts and

123 7-10 wk with glutamic acid decarboxylase-IgG retrovirally transduced B cells, or attenuate it with B

124 When the HFBM was retrovirally transduced before transplantation, integrat

125 n was performed on sensory clones expressing retrovirally transduced beta-galactosidase.

126 as been used to test whether transplant with retrovirally transduced bone marrow (BM) cells (JAK3 BMT

127 10 in macrophages through transplantation of retrovirally transduced bone marrow cells (BMCs).

128 l, we evaluated the long-term engraftment of retrovirally transduced bone marrow cells in nonmyeloabl

129 In this study, normal dogs were given retrovirally transduced bone marrow cells with and witho

130 owing transplantation of syngeneic mice with retrovirally transduced bone marrow or in vitro from tra

131 restricted Ags reliably on the same cell, we retrovirally transduced bone marrow-derived DCs with the

132 Consistent with this, we found that retrovirally transduced c-Myc cannot downregulate endoge

133 were 2 macaques that received transplants of retrovirally transduced CD34(+) cells 2 years previously

134 ple, we used Langerhans cell (LC) progeny of retrovirally transduced CD34(+) hemopoietic progenitor c

135 ansgene expression in T cells generated from retrovirally transduced CD34-enriched hematopoietic prog

136 est and GFP, thus enabling identification of retrovirally transduced cells in subsequent lymphocyte l

137 Retrovirally transduced DC expressed both vIL-10 and EGF

138 These observations suggest that retrovirally transduced DCs have the capacity to present

139 To evaluate the potential efficacy of retrovirally transduced DCs, bone marrow cells harvested

140 Using retrovirally transduced embryonic fibroblasts from a CSL

141 ed to induce tolerance to the product of the retrovirally transduced gene.

142 T cells expressing retrovirally transduced GRP1 exhibited normal proliferat

143 E) to achieve selective growth inhibition of retrovirally transduced HCC cells.

144 CD4zeta- or CD4gamma-expressing T cells from retrovirally transduced hematopoietic stem cells followi

145 Malignancies arising from retrovirally transduced hematopoietic stem cells have be

146 ects can be improved upon transplantation of retrovirally transduced HSCs without overt toxicity and

147 imerism and platelet counts in recipients of retrovirally transduced HSCs.

148 In this study we use retrovirally transduced human cell lines to show that 3D

149 u and Liv-SCID-hu mice became engrafted with retrovirally transduced human hematopoietic precursors t

150 We retrovirally transduced HUVEC to express p100 at a level

151 The TCRs were cloned and retrovirally transduced into either TCRalphabeta-deficie

152 eine motif were randomized and fused to GFP, retrovirally transduced into mammalian cells and iterati

153 ne was isolated from monocyte RNA by PCR and retrovirally transduced into SMEL and PMEL.

154 We conclude that retrovirally transduced LNGFR+/TK+ murine lymphocytes ca

155 When stimulated by cell-surface PSMA, retrovirally transduced lymphocytes undergo robust proli

156 t efficient transduction and expression of a retrovirally transduced major histocompatibility complex

157 Expression of a retrovirally transduced MHC class I Ag, H-2K(b) (K(b)),

158 e with AE to cause leukemia, we transplanted retrovirally transduced murine bone marrow coexpressing

159 ity, recent investigations in cell lines and retrovirally transduced murine fetal liver cells suggest

160 We retrovirally transduced murine iPSCs with a construct co

161 Using an in vitro transformation assay of retrovirally transduced myeloid progenitors, we conducte

162 of newly formed blood vessels by implanting retrovirally transduced myoblasts that constitutively ex

163 Using retrovirally transduced NKL cells and peripheral blood N

164 s-2 cells deficient in COX-2 expression were retrovirally transduced or stably transfected with murin

165 Additional studies demonstrated that retrovirally transduced patient mutant CD3zeta cDNA fail

166 These retrovirally transduced PBL cultures were MART-1 peptide

167 To study its transforming properties, we retrovirally transduced primary murine hematopoietic pro

168 alysis was used to track the contribution of retrovirally transduced primitive progenitors to hematop

169 in primary bone marrow cells, STAT5 and PU.1 retrovirally transduced pro-B cell lines, or embryonic s

170 We recently showed that a retrovirally transduced prolactin receptor (PrlR) effici

171 hery of mice reconstituted with a mixture of retrovirally transduced RAG-1-deficient bone marrow and

172 We show here that a small minority of retrovirally transduced stem cells can be selectively en

173 To develop an animal model that used retrovirally transduced suicidal lymphocytes in a GVHD s

174 Expression of GRAIL in retrovirally transduced T cell hybridomas dramatically l

175 beta chains with the Valpha14 alpha-chain in retrovirally transduced T cell lines, that the Valpha14

176 then generate high-avidity T cell clones and retrovirally transduced T cell populations that kill NPM

177 ssion of pTalpha mutants in transgenic mice, retrovirally transduced T cell precursors and cell lines

178 al memory T-cell subsets using transgenic or retrovirally transduced T cells engineered to express a

179 w reconstitution assay with cells containing retrovirally transduced TAN1 alleles, we analyzed the on

180 sduced LCs did not react preferentially with retrovirally transduced targets, indicating that the res

181 , human HCT-8 and HCT-116 colon cancer cells retrovirally transduced to express a DHFR-herpes simplex

182 o investigate the ability of MDSCs that were retrovirally transduced to express bone morphogenetic pr

183 plantation with autologous bone marrow cells retrovirally transduced to express both SLA class II DR

184 DCp retrovirally transduced to express both vIL-10 and EGFP

185 th tumor cells mixed with CL7.1 fibroblasts, retrovirally transduced to express either the mCD40L or

186 e tissue-derived mesenchymal stem cells were retrovirally transduced to express green fluorescent pro

187 ansplanted with autologous bone marrow cells retrovirally transduced to express HLA-A2.1 develop a si

188 ence of GM-CSF, interleukin-4, and Flt3L and retrovirally transduced to express luciferase (luc) and

189 t alone and as an adjuvant to Neuro-2a cells retrovirally transduced to express murine GM-CSF (GM/Neu

190 w cells from T cell receptor-transgenic mice retrovirally transduced to express the genes encoding th

191 Fibroblasts were retrovirally transduced to overexpress TSP-2 and were se

192 Primary adult mouse myoblasts were retrovirally transduced to secrete human or mouse rVEGF

193 Retrovirally transduced tumor cells secreting biological

194 lial cells (keratinocytes) as a platform and retrovirally transduced wild-type and dominant-negative

195 Human primary T lymphocytes retrovirally transduced with 3G6-CD28 secrete interleuki

196 blood mononuclear cell-derived T cells were retrovirally transduced with a human chNKG2D receptor ge

197 Similarly, HCEKs retrovirally transduced with a miR-31-resistant FIH-1 ha

198 CTL were retrovirally transduced with a model cell surface Ag to

199 Mouse fibroblasts were retrovirally transduced with a single HLA-peptide comple

200 sults provide evidence that human DCs can be retrovirally transduced with a TAA gene and that these t

201 of acid sphingomyelinase-deficient mice, and retrovirally transduced with amphotropic or ecotropic ve

202 , melanoma-reactive human T lymphocytes were retrovirally transduced with an exogenous human IL-2 gen

203 econstitution of mice with bone marrow cells retrovirally transduced with BCR-ABL; (ii) Transgenic mi

204 Jurkat T cells retrovirally transduced with constitutively active H-Ras

205 vents induced by CPA in 9L gliosarcoma cells retrovirally transduced with CYP2B6, or induced in wild-

206 Human umbilical vein endothelial cells retrovirally transduced with Dll4 displayed reduced prol

207 Using HUVEC retrovirally transduced with dominant negative IkappaB k

208 CD4+25- T cells retrovirally transduced with Foxp3 express a panel of ce

209 Bone marrow-derived dendritic cells (BM-DCs) retrovirally transduced with genes encoding murine inter

210 red in p47phox-deficient microglia that were retrovirally transduced with human p47phox cDNA.

211 es of human K562 erythroleukemic cell clones retrovirally transduced with inducible nitric oxide synt

212 mmunoprecipitation from RAW264.7 macrophages retrovirally transduced with IRF-8 and hemagglutinin-ubi

213 doptive transfer of purified CD4(+) T cells, retrovirally transduced with MAGE-A3 TCR plus systemic h

214 We show that transplantation of bone marrow retrovirally transduced with MLL-CBP induces myeloid leu

215 rine Tregs were isolated from recipients and retrovirally transduced with ortho IL-2Rbeta during ex v

216 COMMA-1D mouse mammary epithelial cells were retrovirally transduced with PDK1, and transformation wa

217 stem and progenitor cells (HSPC), which were retrovirally transduced with PML/RARalpha.

218 o model of HI skin using human keratinocytes retrovirally transduced with shRNA targeting ABCA12 in a

219 epsilon RI signaling, SLP-76(-/-) BMMC were retrovirally transduced with SLP-76 and SLP-76 mutants.

220 We reasoned that DCs retrovirally transduced with TAA genes might have import

221 logeneic MHC class II molecules, dTregs were retrovirally transduced with TCR genes conferring specif

222 ceptor (TCR)-transgenic CD4+25- T cells were retrovirally transduced with the Foxp3 gene.

223 s, we used the HL-60 promyelocytic cell line retrovirally transduced with the G185R NE mutant that is

224 fic donor cytotoxic T lymphocytes (CTL) were retrovirally transduced with the herpes simplex virus th

225 nduced by doxorubicin was suppressed in LCLs retrovirally transduced with the Human Papillomavirus 16

226 NK clones retrovirally transduced with the inhibitory KIR2DL3 gene

227 ne AML model in which primary AML cells were retrovirally transduced with the murine B7-1 cDNA.

228 yngeneic Fischer 344 rat smooth muscle cells retrovirally transduced with the rat PAI-1 gene (LPSN gr

229 We used T cells that were retrovirally transduced with this CAR to treat mice bear

230 Primary human T lymphocytes retrovirally transduced with this construct could be pur

231 BS cells from BS cell repertoires, which are retrovirally transduced with tumor-derived cDNA librarie

232 ution with autologous hemopoietic stem cells retrovirally transduced with viruses encoding MHC class

233 g reconstitution with autologous bone marrow retrovirally transduced with viruses encoding protective

234 w transplantation, the question was asked if retrovirally transduced, donor derived, ex vivo expanded

235 ncogenic potency, we compared the effects of retrovirally-transduced mutant (A623I) TSHR or (Q227L) G

236 We retrovirally transfected BJAB lymphoma, THP-1, U937, and

237 Ca(2+) or anti-E-cadherin antibodies or when retrovirally transfected with a dominant-negative E-cadh

238 was assessed using polarized human T84 cells retrovirally transfected with CD23a or CD23b.

239 MARY-X spheroids were retrovirally transfected with FucT-III cDNA, significant

240 However, expression of the retrovirally transferred genes is variable (position eff

241 and expansion, 96.7+/-0.8% of CTL expressed retrovirally transferred genes.

242 We have compared the activity of retrovirally transferred hG6PD driven by these promoters

243 time point that led to the expression of the retrovirally transferred Hlx gene at a time comparable t

244 n, full-length human laminin alpha4 cDNA was retrovirally transferred to HDMEC, and specific overexpr