ライフサイエンスコーパス: retrovirus

1 to other FeLV subgroups or feline endogenous retrovirus.

2 long terminal repeat (LTR) regions from the retrovirus.

3 itted efficient vertical transmission of the retrovirus.

4 s conserved between LTR retrotransposons and retroviruses.

5 orting the unique connection between ALS and retroviruses.

6 irrespective of the evolutionary history of retroviruses.

7 upregulation of nearby genes and endogenous retroviruses.

8 they have not been shown to harbor exogenous retroviruses.

9 enus Felis, predating cat exposure to feline retroviruses.

10 of Refrex-1 predates cat exposure to feline retroviruses.

11 ighlight divergent integration strategies of retroviruses.

12 ndogenous retroviruses (ERVs), and exogenous retroviruses.

13 binding mode might be different from that of retroviruses.

14 s as the basal group within the KoRV-related retroviruses.

15 mune responses against acute infections with retroviruses.

16 n of several exogenous as well as endogenous retroviruses.

17 ise, resembling the formation of recombinant retroviruses.

18 e, and physical properties resemble those of retroviruses.

19 lpha v1 loop affect restriction of divergent retroviruses.

20 ation sites of five DNA viruses and four RNA retroviruses.

21 in a variety of tissues and able to restrict retroviruses.

22 s of success in evolutionary arms races with retroviruses.

23 that abrogates neonatal immune tolerance to retroviruses.

24 genetic elements that are closely related to retroviruses.

25 DA5, and a release of a subset of endogenous retroviruses.

26 in both number and genomic location of these retroviruses.

27 d essentially acted as replication-competent retroviruses.

28 otects against cross-species transmission of retroviruses.

29 so found at the genomic integration sites of retroviruses(2-6) and other transposable elements(7-9),

30 As in all retroviruses, a fraction of HERV-K transcripts is export

31 ggest that testing for replication-competent retroviruses, a routine safety test for transduced cell

32 I/LnJ mice are uniquely resistant to retroviruses acquired as newborns or as adults as they p

33 on is twofold: first, as with other viruses, retroviruses act as agents of selection, driving the evo

34 R retrotransposons of ERV-9 human endogenous retrovirus activated transcription of key erythroid gene

35 ate to the selective targeting of endogenous retroviruses adjacent to Th1 enhancers.

36 tion 3 through an IL-23/acutely transforming retrovirus AKT8 in rodent T-cell lymphoma/signal transdu

37 vity only if the host cell that produced the retrovirus also expressed the cellular entry receptor.

38 tergenic transcripts enriched for endogenous retroviruses, Alu and LINE-1 elements.

39 tic analysis of a pericentromeric endogenous retrovirus amplified by PCR revealed possible gene conve

40 ake blocking of neonatal immune tolerance to retroviruses an achievable goal.IMPORTANCE This work des

41 The interactions between a retrovirus and host cell chromatin that underlie integra

42 NA-derived fragments may also be involved in retrovirus and retrotransposon replication.

43 (2C) transcripts, including MERVL endogenous retrovirus and Zscan4 cluster genes.

44 nd receptors that target the capsid cores of retroviruses and activate ubiquitin-dependent antiviral

45 ion networks and extract core cluster (s) of retroviruses and ALS.

46 rons is a requirement for the replication of retroviruses and also for the expression of many mRNA is

47 , their diversity and their relationships to retroviruses and discusses the potential for ERVs to rev

48 of viral infection, with a primary focus on retroviruses and herpesviruses as examples of recent adv

49 The Gag polyprotein exists in all retroviruses and is a key player in viral assembly.

50 f transposable elements including endogenous retroviruses and latent cancer testis antigens normally

51 ng macrophages captured incoming blood-borne retroviruses and limited their spread to the erythroblas

52 Endogenous retroviruses and long terminal repeat (LTR) retrotranspo

53 Together, endogenous retroviruses and LTR retrotransposons represent major co

54 for ESCRT recruitment, those adopted by the retroviruses and many other families of enveloped RNA vi

55 that provide innate immune defences against retroviruses and mobile elements.

56 cts and presentations from the Conference on Retroviruses and Opportunistic Infections, the Internati

57 have allowed a large diversity of endogenous retroviruses and other endogenous viral elements to colo

58 tent cell-intrinsic restriction mechanism of retroviruses and positive-strand RNA viruses.

59 ERVs are molecular remnants of ancient retroviruses and proof that the ongoing relationship bet

60 reverse transcriptases, are key enzymes for retroviruses and retroelements.

61 Thus, IFI16 restricts retroviruses and retrotransposons by interfering with Sp

62 Retroviruses and retrotransposons commonly appropriate m

63 The lifecycle of retroviruses and retrotransposons includes a reverse tra

64 kes use of universally conserved features of retroviruses and should be widely applicable to other LT

65 ics have been frequently observed in primate retroviruses and their antagonists, host restriction fac

66 ses have the largest genomes among mammalian retroviruses and their vectors have shown potential for

67 proof that the ongoing relationship between retroviruses and their vertebrate hosts began hundreds o

68 ith cell-intrinsic suppression of endogenous retroviruses and type I IFN signaling, and increased exp

69 iruses such as herpes viruses, flaviviruses, retroviruses, and coronaviruses.

70 SERINC5 inhibits the infectivity of diverse retroviruses, and its activity is counteracted by the gl

71 Desilenced endogenous retroviruses are associated with human autoimmune disord

72 Endogenous retroviruses are most significantly enriched in core dom

73 and/or did, replicate.IMPORTANCE Endogenous retroviruses are relics of ancestral virus infections in

74 However, retroviruses are sensed through other mechanisms, persis

75 roles to include the period when endogenous retroviruses are still infectious.

76 uired for full MoMLV pathogenesis.IMPORTANCE Retroviruses are thought to spread primarily via direct

77 DNA transposons and retroviruses are versatile tools in functional genomics

78 this major retroviral lineage, and therefore retroviruses as a whole, have an ancient marine origin a

79 lular resistance to exogenous and endogenous retroviruses as well as other mobile genetic elements.

80 the core structural protein (CA) of an HML2 retrovirus, assemble particles in vitro and employ singl

81 e packaging during virus assembly.IMPORTANCE Retrovirus assembly is a well-choreographed event, durin

82 ally polymorphic; not all individuals have a retrovirus at a specific genomic location.

83 iviral activity against a prototypical avian retrovirus, avian sarcoma and leukosis virus (ASLV).

84 little is known about the ancient origin of retroviruses, but owing to the discovery of their ancien

85 ted in the transcriptional silencing of many retroviruses by binding to DNA sequences in the U3 regio

86 Notably, we observed that restriction of retroviruses by TRIM5alpha does not require autophagic m

87 gradation is required for the restriction of retroviruses by TRIM5alpha.

88 mechanism shared by endogenous and exogenous retroviruses by which ERVs can be inactivated after endo

89 Retroviruses can create endogenous forms on infiltration

90 s in key ISD residues E14 and A20.IMPORTANCE Retroviruses can interact with their hosts in ways that,

91 The tracking of ancestral retroviruses can shed light on their roles in pathogenes

92 Viruses, including retroviruses, can be passed from mothers to their progen

93 The mature retrovirus capsid consists of a variably curved lattice

94 duced with good manufacturing practice-grade retrovirus carrying full-length human COL7A1 and assembl

95 ad are rare, with the only example being the retrovirus causing walleye dermal sarcoma in fish.

96 Our data provide insights into how retroviruses coevolved with the host to co-opt innate im

97 Although MLV is considered a simple retrovirus compared to lentiviruses, it does encode prot

98 d, through the phenomenon of endogenization, retroviruses contribute an abundance of genetic novelty

99 ene geometry previously described for mature retrovirus core particles and a tertiary and quaternary

100 virus type 1, was the first exogenous human retrovirus discovered.

101 he impact of CD169-mediated virus capture on retrovirus dissemination and pathogenesis in vivo is unk

102 es of repetitive elements (LINEs, endogenous retroviruses, DNA transposons, simple repeats, etc.) wer

103 cells was associated with LTR and endogenous retrovirus elements and decreased H4K20me3.

104 cing of developmentally regulated endogenous retrovirus elements.

105 All retroviruses encode a Gag polyprotein containing an N-te

106 Integration is catalysed by the retrovirus-encoded integrase (IN), which forms a tetrame

107 nation signal sequences were transduced with retroviruses encoding either wild-type or 41 naturally o

108 The use of retroviruses encoding fluorescent proteins has allowed t

109 orrelated with the extent to which different retroviruses engage CLIP170 to facilitate infection.

110 e host machinery needed for infection by the retroviruses entering the cell via the ecotropic envelop

111 Retrovirus entry into cells is mediated by the interacti

112 The first is changes in the retrovirus envelope gene allowing virus entry into a non

113 Here, we uncover a full-length endogenous retrovirus envelope protein, dubbed HEMO [human endogeno

114 Here we identify six endogenous retrovirus (ERV) families with AML-associated enhancer c

115 Elevated endogenous retrovirus (ERV) transcription and anti-ERV antibody rea

116 egion, significantly derepressing endogenous retrovirus (ERV)3-1, with promoter demethylation, enhanc

117 Endogenous retroviruses (ERV) are found throughout vertebrate genom

118 their roles in the restriction of endogenous retroviruses (ERV) have been limited to in vitro studies

119 Among them, endogenous retroviruses (ERV) represent sequences that closely rese

120 repeat (LTR)-retrotransposons, or endogenous retroviruses (ERV), account for most novel insertions an

121 High levels of endogenous retrovirus (ERV1) expression were linked to a worse surv

122 Although endogenous retroviruses (ERVs) are known to harbor cis-regulatory e

123 Here, we show that endogenous retroviruses (ERVs) influence species-specific germline

124 in mice as infectious viruses and endogenous retroviruses (ERVs) inserted into mouse chromosomes.

125 Endogenous retroviruses (ERVs) occupy extensive regions of the huma

126 Endogenous retroviruses (ERVs) of domestic cats (ERV-DCs) are one o

127 These exogenous MLVs derive from endogenous retroviruses (ERVs) that were acquired by the wild mouse

128 MLVs) recombine with nonecotropic endogenous retroviruses (ERVs) to produce polytropic MLVs (P-MLVs).

129 In the case of endogenous retroviruses (ERVs), a TE subclass, experimental interro

130 le to other LTR retrotransposons, endogenous retroviruses (ERVs), and exogenous retroviruses.

131 Transposable elements, including endogenous retroviruses (ERVs), constitute a large fraction of the

132 rated retroviral elements, termed endogenous retroviruses (ERVs), that comprise ~8% of the human geno

133 Endogenous retroviruses (ERVs), the majority of which exist as degr

134 the human genome is derived from endogenous retroviruses (ERVs).

135 ent retroviral sequences known as endogenous retroviruses (ERVs).

136 and could serve as a model for understanding retrovirus evolution and pathogenesis in humans.

137 Retroviruses evolved from long terminal repeat (LTR) ret

138 Many viruses, like HIV-1 and related retroviruses, evolved accessory proteins to counteract t

139 Lymph- and blood-borne retroviruses exploit CD169/Siglec-1-mediated capture by

140 ng the durability of T cells transduced with retroviruses expressing each of six commonly used RV rep

141 sal amphibian and fish foamy-like endogenous retroviruses (FLERVs).

142 Using replication incompetent avian retroviruses for precise high-resolution lineage analysi

143 probably reflects the requirement of C-type retroviruses for tighter membrane binding, essential for

144 ine foamy virus (FFV) is a contact-dependent retrovirus forming chronic, largely apathogenic, infecti

145 ), which is the first reproduction-competent retrovirus found in bats.

146 The retrovirus Friend murine leukemia virus (FrMLV) infects

147 a murine model of the splenomegaly-inducing retrovirus Friend virus complex (FVC) infection, we find

148 (WT) mice with various doses of a pathogenic retrovirus (Friend virus) and assessed immune parameters

149 that Tetherin-mediated inhibition of Friend retrovirus (FV) replication at 2 weeks post-infection co

150 RdRP mice also had considerably lower Friend retrovirus (FV) viremia.

151 All retrovirus genera, with the exception of deltaretrovirus

152 1, envelope (ERVW1) and SYNCYTIN2/endogenous retrovirus group FRD member 1, envelope (ERVFRD1), encod

153 ated transcript expression of the endogenous retrovirus group HERV-K (HML-2) is seen in many human ca

154 ML-2) is the most recently active endogenous retrovirus group in humans, and the only group with huma

155 rovirally encoded genes SYNCYTIN1/endogenous retrovirus group W member 1, envelope (ERVW1) and SYNCYT

156 A single, heavily deleted copy of this retrovirus has been found in the genome of miniopterid s

157 Comparative analysis among retroviruses has been critically important in enhancing

158 of retroviral envelope genes from endogenous retroviruses has played a role in the evolution of mamma

159 This suggests that gamma-retroviruses have evolved the EBM to mimic a cognate int

160 Endogenous retroviruses have proved to be a reliable genetic marker

161 imulated gene that can affect replication of retroviruses, hepatitis B virus, and hepatitis C virus (

162 they suppress the maturation of the extinct retrovirus HERV-K (HML-2).

163 reveals that upregulation of the endogenous retrovirus HERV-K could both initiate and sustain activa

164 Characterization of Human Endogenous Retrovirus (HERV) expression within the transcriptomic l

165 ope protein of an endogenized human-specific retrovirus (HERV-K, HML-2) from loci in chromosomes 12 a

166 Human endogenous retroviruses (HERV) form a substantial part of the human

167 Human endogenous retroviruses (HERVs) make up 8% of the human genome.

168 Human endogenous retroviruses (HERVs), which make up approximately 8% of

169 against DNA viruses (HSV, VZV, CMV, HBV) and retroviruses (HIV).

170 governed by RNA elements derived from three retroviruses (HIV-1, murine leukemia virus, and Mason-Pf

171 Successful replication of the AIDS retrovirus, HIV, requires that its genomic RNA be packag

172 Like all retroviruses, HIV-1 irreversibly inserts a viral DNA (vD

173 Like other retroviruses, HIV-2 packages two copies of full-length v

174 viruses, including an oncogenic delta(delta)-retrovirus human T-cell leukemia virus type-1 (HTLV-1).

175 also inhibited the movement of an endogenous retrovirus (IAP), our finding shed new light on this int

176 ence suggests potential roles for endogenous retroviruses in early life events, which may affect adul

177 SAMHD1 that blocks reverse transcription of retroviruses in macrophages by maintaining dNTP pools at

178 aptured the expression profile of endogenous retroviruses in single cells.

179 ther opossum A1 restricts the infectivity of retroviruses including human immunodeficiency virus type

180 omes is a critical step in the life-cycle of retroviruses, including an oncogenic delta(delta)-retrov

181 Certain retroviruses, including HIV, insert their DNA in a non-r

182 tional IN binding partner exclusive to delta-retroviruses, including human T cell lymphotropic virus

183 KAP1-HDAC1 complex that represses endogenous retroviruses independently of ATRX and H3.3 incorporatio

184 Retroviruses infect a broad range of vertebrate hosts th

185 These retroviruses infect a variety of CNS cell types; however

186 During cat evolution, various exogenous retroviruses infected different cat lineages and generat

187 ical interneurons originating from low-titre retrovirus-infected radial glial progenitors in the embr

188 innate immune sensor that potently restricts retrovirus infection by binding to human immunodeficienc

189 rs provide the first line of defense against retrovirus infection by posing several blocks to the vir

190 r syndrome protein (WRN) and in Modulator of retrovirus infection homologue (MRI).

191 In a Friend retrovirus infection model, CTLA-4 blockade in particula

192 as been extensively analyzed, few studies of retrovirus infection of human EC cells have been perform

193 ant function of CD4+ T cells during an acute retrovirus infection seems to be their helper function f

194 ay important roles in intrinsic responses to retrovirus infection.

195 unosuppressive activity were shown to affect retrovirus infectivity only if the host cell that produc

196 s on HIV-1 replication.IMPORTANCE Endogenous retroviruses inhabit big portions of our genome.

197 Atomic structures of five different retrovirus INs complexed with their respective viral DNA

198 The retrovirus integrase (IN) inserts the viral cDNA into th

199 oprotein of diverse endogenous and exogenous retroviruses is considered inherently immunosuppressive.

200 the repression of specific murine endogenous retroviruses is dependent on DAXX, but not on ATRX.

201 nd pathogenesis.IMPORTANCE Immune control of retroviruses is notoriously difficult, a fundamental pro

202 The structural protein Gag, found in all retroviruses, is a polyprotein comprising three major fu

203 Jaagsiekte sheep retrovirus (JSRV) is the etiologic agent of ovine pulmon

204 disease of sheep caused by jaagsiekte sheep retrovirus (JSRV).

205 to increased expression of human endogenous retrovirus K (HERV-K) in PAH versus control lungs (n=4).

206 human pegivirus (n=1, 4%), human endogenous retrovirus K (n=27, 100%), and anellovirus (n=15, 56%).

207 2) and GCM (n=13) contained human endogenous retrovirus K.

208 nonical imprints are localized to endogenous retrovirus-K (ERVK) long terminal repeats (LTRs), which

209 Human endogenous retrovirus-K (HERV-K) human mouse mammary tumor virus-li

210 bbon ape leukemia virus (GALV) and the koala retrovirus (KoRV) are very closely related, yet their ho

211 Koala retrovirus (KoRV) displays features of both an endogenou

212 Koala retrovirus (KoRV) is in the process of endogenization in

213 lls are evident in mice infected with Friend retrovirus, LCMV Clone 13, and in patients with chronic

214 Complex retroviruses like human immunodeficiency virus type 1 (H

215 Once virus assembly is complete, retroviruses, like most enveloped viruses, utilize host

216 We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and d

217 of 2C-like markers such as murine endogenous retrovirus-like elements (MERVL) and Zscan4.

218 often carry long terminal repeats (LTRs) for retrovirus-like reverse transcription and integration in

219 Hundreds of retrovirus-like sequences have features that suggest the

220 of Saccharomyces cerevisiae, Ty1, which is a retrovirus model.

221 ther vesicular stomatitis virus (VSV) or the retrovirus MoMLV.

222 HERV-W (pHERV-W) ENV (formerly MS-associated retrovirus [MSRV]-ENV).

223 zed the RNA modifications present in a model retrovirus, murine leukemia virus (MLV), using mass spec

224 To establish infection, a retrovirus must insert a DNA copy of its RNA genome into

225 arting with bacteriophages and moving to the retroviruses, my use of the tools of genetics, molecular

226 r mammalian) hosts, including herpesviruses, retroviruses, Mycobacterium tuberculosis, and Toxoplasma

227 All retroviruses need to integrate a DNA copy of their genom

228 ng of the gene responsible for production of retrovirus-neutralizing antibodies in mice of the I/LnJ

229 Because retroviruses of different morphogenetic types assemble t

230 rther studies on the influence of endogenous retroviruses on HIV-1 replication.IMPORTANCE Endogenous

231 The long-term impact of retroviruses on vertebrate evolution is twofold: first,

232 key part of individual cells (as endogenous retroviruses or persistent infection) and multicellular

233 nisms, often deleteriously mutating invading retroviruses or retrotransposons and, in the case of AID

234 iple functionalities cooperate to generate a retrovirus particle.

235 s-species transmission of porcine endogenous retroviruses (PERVs) has impeded the clinical applicatio

236 the risk of transmitting porcine endogenous retroviruses (PERVs).

237 and statistical analysis of the ALS-PIN and retrovirus-PIN identified a shared, essential protein ne

238 Emerging evidence suggests retroviruses play a role in the pathophysiology of amyot

239 ir high genomic variability, RNA viruses and retroviruses present a unique opportunity for detailed s

240 The integrase (IN) enzyme of retrovirus prototype foamy virus (PFV) consists of four

241 er 2 (SLC20A2) and xenotropic and polytropic retrovirus receptor 1 (XPR1) are transporters with phosp

242 phosphate exporter xenotropic and polytropic retrovirus receptor 1 (XPR1) revealed that it is regulat

243 ember 2 (SLC20A2), xenotropic and polytropic retrovirus receptor 1 (XPR1), myogenesis regulating glyc

244 heavily reliant on Xenotropic and Polytropic Retrovirus Receptor 1 (XPR1), regulation of which is lar

245 The perturbation of specific retrovirus-receptor interactions under selective pressur

246 ery and characterization of a group of koala retrovirus-related (KoRV-related) gammaretroviruses in A

247 group of LTRs from the mammalian endogenous retrovirus-related ERVL retrotransposon class on gene ex

248 2 is a host restriction factor that inhibits retrovirus release from infected cells in vitro by tethe

249 The resulting potent inhibition of retrovirus release underscores the importance of underst

250 roach termed cellular labeling of endogenous retrovirus replication (CLEVR), which reports replicatio

251 1, and murine IFI16 homologs restrict Friend retrovirus replication in mice.

252 ost abundant mRNA modification-in regulating retrovirus replication, the identification and function

253 discrete steps of the post-entry pathway of retrovirus replication.

254 ferent import factors play distinct roles in retrovirus replication.

255 log of MOV10 helicase, a retrotransposon and retrovirus restriction factor in human.

256 expression, we have uncovered repressors of retrovirus (RV) activity as modifiers of CHMP2BIntron5 t

257 Integrase from HIV-1 and closely related retroviruses share the three-domain organization, consis

258 rs derived from foamy virus, a nonpathogenic retrovirus, show higher preference for nongenic integrat

259 r SETDB1's enzymatic activity and endogenous retrovirus silencing in murine embryonic stem cells.

260 strongly inducing MuERV-L (MERVL) endogenous retroviruses, similar to what is seen with features of t

261 endogenous retrotransposon human endogenous retrovirus subfamily H (HERV-H) in creating topologicall

262 suggest a possible mechanism by which human retroviruses such as HERV-K might contribute to TDP-43-m

263 nctions as an innate barrier to infection by retroviruses such as HIV-1, and controls LTR/non-LTR ret

264 m cytoplasmic bodies involved in restricting retroviruses such as HIV-1.

265 tion factors - which defend against invading retroviruses such as HIV-1.

266 culture, and given its similarities to human retroviruses such as HTLV-1, the development of an effec

267 A hallmark of retroviruses such as human immunodeficiency virus type 1

268 The ESCRT machinery is also hijacked by retroviruses, such as HIV-1, to release virions from inf

269 enome by inhibiting retroelements as well as retroviruses, such as HIV-1.

270 The strong dependence of retroviruses, such as human immunodeficiency virus type

271 CE chNHE1 is a cellular receptor of ALV-J, a retrovirus that causes infections in chickens and seriou

272 ukemia virus type 1 (HTLV-1) is an oncogenic retrovirus that induces a fatal T-cell malignancy, adult

273 A retrovirus that infected our ancestors 100 million years

274 BLV is a retrovirus that is found worldwide in domestic cattle.

275 In addition, retroviruses that encode either PSD95:GFP or Syn:GFP rev

276 Syncytins are envelope genes from endogenous retroviruses that have been captured during evolution fo

277 LV-1) and type 2 (HTLV-2) are highly related retroviruses that have distinct pathological outcomes in

278 t have evolved to mediate resistance against retroviruses that use Nef-like proteins to antagonize SE

279 For retroviruses, the Gag structural protein is the primary

280 We found that, in contrast to retroviruses, these do not change size or shape upon mat

281 re whether connections exist between ALS and retroviruses through protein interaction networks (PIN)

282 Here, we used a retrovirus to visualize functionally relevant morphologi

283 Here, using retroviruses to birth date and manipulate newborn neuron

284 ells can exploit remnants of once-infectious retroviruses to regulate antiviral gene expression.

285 oughout the lifetime in rodents, we used RGB retroviruses to study the temporary course of these alte

286 sons are mobile elements that are able, like retroviruses, to copy and move inside eukaryotic genomes

287 The HUSH complex represses retroviruses, transposons and genes to maintain the inte

288 Expression of the human endogenous retrovirus type K (HERV-K) has been associated with vari

289 Human Endogenous Retrovirus type K (HERV-K) is the only HERV known to be

290 Expression of the Human Endogenous Retrovirus Type K (HERV-K), the youngest and most active

291 reviously demonstrated that human endogenous retrovirus type W (HERV-W) negatively affects oligodendr

292 HIV, like many retroviruses, utilizes a -1 programmed ribosomal framesh

293 ession of Gata4, Mef2c, and Tbx5 (GMT) using retrovirus vectors.

294 -encoding elements like LINE-1 or endogenous retroviruses via a process termed retrocopying.

295 ine deaminases cause lethal hypermutation of retroviruses via deamination of newly reverse-transcribe

296 essential for assembly, unlike for D/B-type retroviruses, which assemble in the cytoplasm.

297 Human immunodeficiency virus 1 (HIV-1) is a retrovirus with a ten-kilobase single-stranded RNA genom

298 Accordingly, most work has focused on retroviruses with obligate ssDNA replication intermediat

299 recently acquired family of human endogenous retroviruses, with many proviruses less than one million

300 s spreading death is caused by an endogenous retrovirus within the glia, which leads to DNA damage an