ライフサイエンスコーパス: reversal learning

1 avioral flexibility after negative feedback (reversal learning).

2 and flexibility of cue-outcome associations (reversal learning).

3 ed to play a permissive role in this form of reversal learning.

4 tially to processes such as set-shifting and reversal learning.

5 make distinct contributions to probabilistic reversal learning.

6 show no deficits in spatial reference memory reversal learning.

7 n these animals, which also show deficits in reversal learning.

8 ve deficits in hippocampal-dependent spatial reversal learning.

9 but volume of neither region correlated with reversal learning.

10 nal shift abilities and impairment of serial reversal learning.

11 ponse to changes in reward is discrimination reversal learning.

12 r BLA (or SHAM) on visual discrimination and reversal learning.

13 with OFC, may be differentially involved in reversal learning.

14 r errors during initial acquisition and also reversal learning.

15 ulsivity, compulsivity, motivation, and rule-reversal learning.

16 r example, with a negative affective bias in reversal learning.

17 o updating current beliefs during stochastic reversal learning.

18 ic, integrity being important for successful reversal learning.

19 the cognitive processes underlying impaired reversal learning.

20 ve learning, shifts of attentional sets, and reversal learning.

21 ial caudate nucleus on serial discrimination reversal learning.

22 OFC and medial caudate in the regulation of reversal learning.

23 e OFC and VLPFC in the performance of serial reversal learning.

24 lofen and muscimol, on place acquisition and reversal learning.

25 f inactivation, which concomitantly impaired reversal learning.

26 ontrol over visual object representations in reversal learning.

27 learning tasks, namely serial and concurrent reversal learning.

28 ns, but impairs performance on tasks such as reversal learning.

29 ing, and reward-based tasks like gambling or reversal learning.

30 ate poor decision making and are impaired in reversal learning.

31 ctions that differentiate different forms of reversal learning.

32 of the amygdala in rhesus monkeys on object reversal learning.

33 C) has long been associated with deficits in reversal learning.

34 odor cup contained a cereal reinforcement in reversal learning.

35 rats, failed to change cue preference during reversal learning.

36 ncoding in basolateral amygdala (ABL) during reversal learning.

37 ns, while ABL lesions alone had no effect on reversal learning.

38 striatum and the different phases of visual reversal learning.

39 average striatal choline was associated with reversal learning.

40 ociated with performance specifically during reversal learning.

41 injection prevented its beneficial effect on reversal learning.

42 ptors alter anxiety, social interaction, and reversal learning.

43 retention of memory, pattern separation, and reversal learning.

44 rd-based decision-making task: probabilistic reversal-learning.

45 of long-term memory, disrupted retention of reversal learning 24 h later in saline-, but not METH-,

46 (an acetylcholine precursor) changes during reversal learning (a measure of behavioral flexibility)

47 Blockade of alpha5-GABARs accelerates reversal learning, a behavioral test for cognitive flexi

48 ronic intermittent cold (CIC) stress impairs reversal learning, a form of cognitive flexibility media

49 gnaling in the orbitofrontal cortex (OFC) in reversal learning, a form of cognitive flexibility that

50 triatal cholinergic system is fundamental to reversal learning, a key paradigm for studying behaviora

51 The results revealed that during reversal learning, a network including anterior cingulat

52 ) and amygdala are thought to participate in reversal learning, a process in which cue-outcome associ

53 amygdala yield severe impairments on object reversal learning, a task that assesses the ability to s

54 observed maintenance of prefrontal-dependent reversal learning ability.

55 if color preferences impact associative and reversal learning ability.

56 Domesticated fish did not show reversal learning ability.

57 eference for red or green impact associative reversal learning ability.

58 on on dorsomedial striatal ACh output during reversal learning and a resting condition.

59 Whilst both models led to deficits in reversal learning and extra-dimensional set-shifting, th

60 medial prefrontal cortex, which also mediate reversal learning and extra-dimensional set-shifting.

61 tasks in the battery: object discrimination reversal learning and instrumental extinction.

62 tly more trials and committed more errors on reversal learning and multidimensional discriminations,

63 al Arg inhibition also retarded instrumental reversal learning and potentiated responding for reward-

64 reveal a Pin1-mediated mechanism regulating reversal learning and provide potential targets for the

65 cognitive control of adaptive behavior using reversal learning and reinforcer devaluation paradigms.

66 imals were then tested on a cross-maze-based reversal learning and set-shifting task, after which the

67 Rdx gene knockout impairs reversal learning and short-term memory, and Rdx phospho

68 as 11 and 13 do not critically contribute to reversal learning and that adjacent damage to OFC subfie

69 The highest dose of CRF (20 ng) facilitated reversal learning and the lowest dose (2 ng) improved ED

70 of strategy set shifting to facilitation of reversal learning and this was most prominent in a subpo

71 er ethanol-induced changes in OFC-dependent (reversal learning) and mPFC-dependent (set-shifting) beh

72 CRF impaired intradimensional set shifting, reversal learning, and extradimensional set shifting (ED

73 ory, attentional-set formation and shifting, reversal learning, and response inhibition are compared

74 vity was recorded during stable performance, reversal learning, and strategy switching.

75 Cognitive tasks employed were stimulus reversal learning as a measure of cognitive flexibility/

76 xcitotoxic amygdala lesions performed object reversal learning as quickly as controls.

77 1R during the early (perseverative) phase of reversal learning as well as in the intermediate and lat

78 mice did display a selective enhancement in reversal learning, as measured using Morris water-maze a

79 c silencing of lateral OFC neurons disrupted reversal learning, as well as plasticity in S1.

80 WAY163909 was given prior to reversal learning at baseline and after extended HCD or

81 barbital-exposed rats were also assessed for reversal learning at weaning.

82 The first assay tests reversal learning, attentional set formation and shiftin

83 ffects of the 5-HT(2C)R agonist WAY163909 on reversal learning before and after extended HCD or METH

84 We used reversal learning behavior and computational modeling to

85 a behaviorally specific bi-phasic deficit in reversal learning, being consistently impaired at both r

86 n the level of training subjects received in reversal learning, being far greater in the latter.

87 at the disconnection severely impairs serial reversal learning but leaves concurrent reversal learnin

88 Morphine and dizocilpine also impaired reversal learning but only at doses that also affected p

89 acquisition of spatial learning, as well as reversal learning, but are not necessary for the retriev

90 te fear memory formation as well as improved reversal learning, but do not display alterations in hip

91 itor DO34 show delays in MWM acquisition and reversal learning, but no deficits in expression, extinc

92 These data suggest reversal learning, but not attention set-shifting, is tr

93 interneurons in orbitofrontal cortex during reversal learning by recording single unit activity from

94 in ABA and improved flexibility during early reversal learning by reducing perseverative responding.

95 tations in inferotemporal cortex (IT) during reversal learning by studying the effect, in macaque mon

96 of nicotine and varenicline on probabilistic reversal learning choice behavior.

97 icide ideators showed impaired probabilistic reversal learning compared to both nonsuicidal depressed

98 rial reversal learning but leaves concurrent reversal learning completely intact.

99 During mirror-reversal learning, correct movement initiation (feedforw

100 Moreover, prediction errors associated with reversal learning correlated with striatal activation.

101 tor responses to spatial locations) and hot (reversal learning, decision-making under risk, and stimu

102 er ketamine also corrects the stress-induced reversal learning deficit, and if JAK2/STAT3 signaling i

103 or to testing rescued the CIC stress-induced reversal learning deficit.

104 ng in the OFC rescued the CIC stress-induced reversal learning deficit.

105 eurons was critical to the expression of the reversal-learning deficit in the cocaine-treated rats.

106 l cortex (OFC) has long been associated with reversal learning deficits in several species.

107 howed that LSN2463359 selectively attenuated reversal learning deficits in the MAM but not acute PCP

108 Reversal learning deficits were no longer present when m

109 Reversal learning deficits were revealed as greater numb

110 es), less motivation to obtain a reward, and reversal learning deficits, vs. NA-born WT mice.

111 his framework to explain classic findings in reversal learning, delayed alternation, extinction, and

112 rced behaviors more slowly, have deficits in reversal learning demonstrating behavioral inflexibility

113 ional and extra-dimensional set-shifting and reversal learning digging paradigm.

114 showed that behavioral flexibility during a reversal learning discrimination task was reduced in alc

115 sual differences in clock speed, deficits in reversal learning, distortions in temporal memory, and l

116 During reversal learning, dorsal anterior cingulate inactivatio

117 ociated with impairments in learning but not reversal learning (executive component).

118 d by increased anxiety and preceded impaired reversal learning, expressed by a decrease in lose-shift

119 ge-related differences in discrimination and reversal learning for olfactory and visual stimuli in 6-

120 amined the neural mechanisms associated with reversal learning for outcomes versus motor responses.

121 cant decline in spatial reference memory and reversal learning from both young and middle-aged mice.

122 ed (COC) animals showed specific deficits in reversal learning; furthermore, spontaneous LFP oscillat

123 vity coupling increased significantly in the reversal learning group in comparison with controls.

124 Reversal learning has been extensively studied across sp

125 Reversal learning has been studied as the process of lea

126 Research in reversal learning has mainly focused on the functional r

127 erstanding the neural substrates involved in reversal learning has provoked a great deal of interest

128 Deficits in reversal learning have been seen after manipulations of

129 Studies of visual discrimination reversal learning have revealed striking neurochemical d

130 These findings suggest that reversal learning impairments in patients with developme

131 Pf inactivation selectively impaired reversal learning in a dose-dependent manner.

132 tion of the odor discrimination but impaired reversal learning in a dose-dependent manner.

133 inge-type ethanol regimen exhibited impaired reversal learning in a modified Barnes maze, indicative

134 We found that moderate stress enhanced late reversal learning in a mouse touchscreen-based choice ta

135 BQCA also restored discrimination reversal learning in a transgenic mouse model of Alzheim

136 splayed normal initial learning but improved reversal learning in both Morris water maze and lever pr

137 striatal involvement in the negative bias in reversal learning in depression.

138 effects of long-term HCD and METH intake on reversal learning in female rhesus monkeys.

139 Arc into the shell impaired consolidation of reversal learning in METH-, but not saline-, pretreated

140 y showed that decreasing MD activity impairs reversal learning in mice.

141 on in a breakpoint assay and did not promote reversal learning in MK-801-treated mice.

142 of these neurotransmitters in probabilistic reversal learning in nearly 700 individuals as a functio

143 ing the lateral orbitofrontal cortex, during reversal learning in OCD patients and their clinically u

144 l documented impairments on various forms of reversal learning in rodents, monkeys, and humans.

145 triatal function by infusion of AP5 impaired reversal learning in saline-, but not METH-, pretreated

146 activity in mPFC is associated with impaired reversal learning in Sapap3-KOs, providing a likely neur

147 manner in which these regions may facilitate reversal learning in situations involving reward uncerta

148 ent theories disagree on whether OFC directs reversal learning in the amygdala.

149 iations suggests their importance in outcome reversal learning in the face of interference.

150 TgF344-AD rats had impaired reversal learning in the Morris water maze compared to t

151 Intra-ventral subiculum CNO enhanced reversal learning in the same manner as systemic CNO and

152 tor tasks and were significantly impaired in reversal learning in the water maze task post-TBI.

153 20 healthy participants during probabilistic reversal learning, in a placebo-controlled design.

154 s norvegicus) Pf supports flexibility during reversal learning, in part, by modifying dorsomedial str

155 -making processes, assessed by probabilistic reversal learning, in rats before and after they were ex

156 ofrontal cortex (OFC) - a region involved in reversal learning- in rats performing an odor learning a

157 irments in cognitive flexibility and spatial reversal learning, including impaired extinction during

158 However, despite the fact that reversal learning is associated with striatal response i

159 Subsequent reversal learning is enhanced by confidence.

160 pulsive disorder and schizophrenia, in which reversal learning is impaired, and which are primarily t

161 Reversal learning is often studied as a form of flexible

162 However, reversal learning is often studied in animals that have

163 We propose that reversal learning is supported by complex interactions b

164 tes that one type of behavioral flexibility, reversal learning, is dependent upon proper numbers of G

165 ted contingency changes, as occurs in serial reversal learning, is likely to trigger the development

166 While MD hypofunction impaired reversal learning, it did not affect the ability to lear

167 w that fear extinction, an important form of reversal learning, leads to a dramatic genome-wide redis

168 After extensive training in reversal learning, marmosets received an excitotoxic les

169 y, but is no longer, associated with reward; reversal learning, measuring the rate and extent of swit

170 ed drug-free 24 h after OFC inactivation and reversal learning, memory for the newly learned continge

171 Accordingly, neither VOR phase-reversal learning nor locomotion was impaired following

172 d AMG make different contributions to object reversal learning not highlighted previously.

173 hmt1(+/-) mice in the Visual Discrimination &Reversal learning, object-location Paired-Associates lea

174 Serial reversal learning of 2-choice discriminations was contra

175 al anterior cingulate on the acquisition and reversal learning of a 4-choice odor discrimination.

176 striatal network of nonhuman primates during reversal learning of feature values.

177 The cognitive flexibility required for reversal learning of previously acquired behavioral habi

178 implicate a critical contribution to object reversal learning of structures nearby the amygdala, per

179 Recently, we have developed a model of phase-reversal learning of the vestibulo-ocular reflex, a well

180 ast, higher doses of the D1 agonist improved reversal learning only in individuals with low baseline

181 st, stress was not found to adversely affect reversal learning or dendritic morphology in the lateral

182 ehavioral flexibility, as measured by object reversal learning, or emotion regulation, as assessed by

183 ional magnetic resonance imaging and a novel reversal learning paradigm, the present study examined t

184 h the acquisition of new information using a reversal learning paradigm.

185 he marmoset VLPFC in performance of a serial reversal learning paradigm.

186 mate controls were tested in an instrumental reversal-learning paradigm to assess cognitive flexibili

187 ve choice behavior in adolescent rats with a reversal-learning paradigm.

188 abstinence (72 hrs), CIE mice showed reduced reversal learning performance as compared to controls.

189 mirrored that of a hyperbolic function, with reversal learning performance being poorest in either mo

190 ist SCH23390 with CNO prevented the enhanced reversal learning performance seen in the previous two e

191 like receptor PET measurements is related to reversal-learning performance and sensitivity to positiv

192 ayesian approach we find that variability in reversal-learning performance attributable to different

193 nt-learning mechanisms and are predictive of reversal-learning performance in adulthood.

194 , we demonstrate that age-related changes in reversal-learning performance in male and female Long-Ev

195 dopamine transporter (DAT) availability and reversal-learning performance were measured before and a

196 Sapap3-KOs displayed heterogeneous reversal-learning performance, with almost half (n = 13/

197 d reinforcement learning, like probabilistic reversal learning (PRL), but the neural bases for those

198 on positive and negative outcomes we used a reversal learning procedure to assess how reward conting

199 ical for acquisition of new memories and for reversal learning, processes that are thought to be cruc

200 Here, we developed a reversal-learning protocol for the rapid assessment of a

201 BLA lesions, conversely, showed facilitated reversal learning relative to SHAM and OFC groups.

202 dependent pairwise visual discrimination and reversal learning, relative to air-exposed controls.

203 Given that reversal learning requires an intact OFC, these findings

204 attentional set-shifting and discrimination reversal learning, respectively.

205 ) and made fewer perseverative errors during reversal learning (REV).

206 rformance on tasks of visual discrimination, reversal learning, rule-based, or object-spatial paired

207 -accuracy tradeoff and offline gains, mirror-reversal learning shares common features with other skil

208 Plaur mice have impaired reversal learning, similar to deficits observed in patie

209 In serial reversal learning, subjects learn to respond differentia

210 cortically to other structures implicated in reversal learning, such as the medial caudate nucleus.

211 K/STAT signaling pathway in the OFC impaired reversal learning, suggesting that basal IL-6 and JAK/ST

212 ice were able to learn, but were impaired in reversal learning, suggesting that these mice present co

213 e tests including a food reward T-maze test, reversal learning T-maze test, a social preference T-maz

214 ing in adult male rats using a probabilistic reversal learning task and used positron emission tomogr

215 ers and nonsmokers completed a probabilistic reversal learning task during acquisition of functional

216 processing was assessed with a probabilistic reversal learning task during event-related functional M

217 nonhuman primate performing a feature-based reversal learning task evaluating performance using Baye

218 Here we developed a reversal learning task for head-fixed mice, monitored th

219 xamined flexible behavior on a probabilistic reversal learning task in 572 children, adolescents, and

220 hment-based learning using the probabilistic reversal learning task in 65 individuals age 60 and olde

221 and measured performance in a T-maze spatial reversal learning task in male Sprague-Dawley rats.

222 The subjects performed a reversal learning task in which they first had to learn

223 d obese participants performed an appetitive reversal learning task in which they had to learn and mo

224 ine, disrupted behavior in the probabilistic reversal learning task measured by selective impairments

225 -guided choice behavior on the probabilistic reversal learning task predicted greater escalation of c

226 de, and a greater difficulty in performing a reversal learning task relative to baseline performance.

227 low or high trait social anxiety performed a reversal learning task requiring learning actions in res

228 Using an aversive reversal learning task that required subjects to learn,

229 RDMP can robustly perform the probabilistic reversal learning task via dynamic adjustment of learnin

230 6 years) were examined using a probabilistic reversal learning task while simultaneous functional mag

231 MRI to compare the hemodynamic response to a reversal learning task with mixed reward- and punishment

232 Additionally, in a spatial reversal learning task, 2CKO mice failed to improve thei

233 ion disrupted performance on a serial object reversal learning task, although aspiration lesions of t

234 ngage dorsomedial striatum during a response-reversal learning task, as their performance is insensit

235 In the reversal learning task, the n-3 fatty acid-deficient rat

236 Using a reversal learning task, we found that amygdala blood oxy

237 keys engaged in a deterministic three-choice reversal learning task, we found that changes in GPe dis

238 of Bayesian learning under uncertainty in a reversal learning task, we investigate the relationship

239 and stochastic versions of a two-arm bandit reversal learning task.

240 subregions in the context of an instrumental reversal learning task.

241 erformance on a probabilistic two-arm bandit reversal learning task.

242 sessed decision making using a probabilistic reversal learning task.

243 male: 21, male: 6) performed a probabilistic reversal learning task.

244 d longer latency to find the platform in the reversal learning task.

245 MG lesions that had been tested on an object reversal learning task.

246 aques while they executed a two-armed bandit reversal learning task.

247 flexible adjustment of visual attention in a reversal learning task.

248 on making in rats trained on a probabilistic reversal learning task.

249 nd punishment-based learning task, such as a reversal learning task.

250 e (cognitive flexibility) in a probabilistic reversal learning task.

251 were related to anticipatory strategies in a reversal learning task.

252 patial learning and memory and a consecutive reversal learning task; (2) cognitive performance in bot

253 After 3-5 weeks, rats were trained on the reversal-learning task and in situ hybridization for Arc

254 idence that value-based choice behavior in a reversal-learning task improves during adolescence in ma

255 , myelin staining, and a novel three-choice, reversal-learning task to identify early behavioral mark

256 a novel three-choice spatial acquisition and reversal-learning task with probabilistic reinforcement.

257 eously acquired fMRI, during a probabilistic reversal-learning task, to offer evidence of temporally

258 levant distractors (flanker arrows) within a reversal-learning task, with intermixed free and instruc

259 orsal to ventral striatal involvement in the reversal-learning task.

260 triatum (DLS) on a touchscreen visual serial reversal-learning task.

261 ard than unexpected punishment feedback on a reversal-learning task.

262 nd performance in a frontal-cortex-dependent reversal-learning task.

263 ght to determine whether this may be because reversal learning tasks conventionally used to study beh

264 ive performance in both spatial learning and reversal learning tasks was not significantly different

265 of nine macaques were taught discrimination reversal learning tasks, and its impact on gray matter w

266 We tested two visual object reversal learning tasks, namely serial and concurrent re

267 " manner, a function thought to be tested by reversal learning tasks.

268 ced animals have decision-making deficits in reversal-learning tasks and more complex 'gambling' vari

269 Impaired cognitive flexibility in visual reversal-learning tasks has been observed in a wide rang

270 spectively, impairs flexible responding in a reversal learning test, suggesting that these neurochemi

271 effected improvement over the course of the reversal learning test, with controls showing a signific

272 , OFC lesions displayed significantly slower reversal learning than SHAM and BLA rats across sessions

273 with low brain DHA have a deficit in spatial reversal learning that could be related to changes in do

274 Because 5-HT facilitates reversal learning, the present results suggest that stre

275 During initial task acquisition and initial reversal learning, there was a remarkable change in the

276 hat D1R and D2R modulate different stages of reversal learning through effects localised to different

277 sic responses both during discrimination and reversal learning to decisions and rewards, and the stre

278 Furthermore, we report that reversal-learning trajectories in adolescence reliably p

279 n of the NAc shell and core on probabilistic reversal learning using an operant task wherein a "corre

280 rons, whose activity we could link to normal reversal learning using pharmacogenetics.

281 st examination of age-related differences in reversal learning using the same paradigm for odors and

282 that although the OFC is indeed critical for reversal learning, ventrolateral prefrontal cortex (VLPF

283 ected mice exhibited cognitive deficits in a reversal learning version of the Morris water maze.

284 Reversal learning was assessed in all animals reaching c

285 ical and striatal activation associated with reversal learning was assessed via quantitative analysis

286 gence of learning-dependent asymmetry during reversal learning was associated with decreased function

287 approximately 30% above basal levels) during reversal learning was blocked by Pf inactivation, which

288 The deficit in reversal learning was comparable for odors and objects.

289 In contrast, reversal learning was impaired by D2R antagonism, but no

290 Reversal learning was improved after dopamine receptor b

291 VOR phase-reversal learning was singularly impaired in these anima

292 implementation of anticipatory strategies in reversal learning, we first studied, in 20 healthy indiv

293 Using reversal learning, we found that symptomatic veterans sh

294 amine the contribution of areas 11 and 13 to reversal learning, we tested monkeys with selective dama

295 s in acquisition, recall, perseveration, and reversal learning were evident 1 month after CUS.

296 between stimulus-reward associations (i.e., reversal learning) when reinforcement is predictable.

297 ic, and anterior cingulate) on probabilistic reversal learning wherein "correct" versus "incorrect" r

298 the integration of negative feedback during reversal learning, whilst orbitofrontal 5-hydroxytryptam

299 This sparing of reversal learning will be discussed in relation to defic

300 at dose we examined the faster feature-based reversal learning with Guanfacine with single-subject co