ライフサイエンスコーパス: reverse remodeling

1 ion asynchrony, and LV end-systolic volume ("reverse remodeling").

2 ties characteristic of severe heart failure (reverse remodeling).

3 n that have been referred to collectively as reverse remodeling.

4 unctional recovery of scarred myocardium and reverse remodeling.

5 l scar, and these changes predict subsequent reverse remodeling.

6 paced ECG, anticipate higher probability of reverse remodeling.

7 avefront fusion, were positive predictors of reverse remodeling.

8 eft ventricular ejection fraction and led to reverse remodeling.

9 gree of decrease in MVO2, and the rate of LV reverse remodeling.

10 continuous flow assist devices on dystrophin reverse remodeling.

11 rt function by neuroendocrine modulation and reverse remodeling.

12 tion to the left (p < 0.01), compatible with reverse remodeling.

13 tor underlying several important features of reverse remodeling.

14 associated with suboptimal postoperative LV reverse remodeling.

15 2), P=0.01), and suboptimal postoperative LV reverse remodeling.

16 uring follow-up, 28% showed left ventricular reverse remodeling.

17 ciated with left atrial and left ventricular reverse remodeling.

18 ing CRT best explained patient variations in reverse remodeling.

19 ar, and molecular aspects of LVAD-associated reverse remodeling.

20 w-up than patients with discordant or lesser reverse remodeling.

21 h favorable left ventricular and left atrial reverse remodeling.

22 s with LVSD had evidence of left ventricular reverse remodeling.

23 nths and associated with interval 3-month LV reverse remodeling.

24 one to make a decision in the prediction of reverse remodeling.

25 ved LV ejection fraction, consistent with LV reverse remodeling.

26 esult in a higher degree of left ventricular reverse remodeling.

27 used in patients with HF, leading to partial reverse remodeling.

28 myocardial infarction is associated with LV reverse remodeling.

29 NT-proBNP, improvement in health status, and reverse remodeling.

30 sized that late repair will not result in LV reverse remodeling.

31 ng, and metabolic genes were associated with reverse-remodeling.

32 olic function adaptations during myocardial (reverse) remodeling.

33 associated with substantial left ventricular reverse remodeling; (2) its absence can cause beta-block

34 er potential for myocardial recovery through reverse remodeling, a potential that is further enhanced

35 ith LBBB, 212 (40%) with complete left-sided reverse remodeling (above-median change in both LAV and

36 th LAV and LVESV), 115 (22%) with discordant reverse remodeling (above-median change in only LAV or L

37 LA forward and reverse remodeling affect prognosis in patients with chr

38 f factors that are associated with favorable reverse remodeling after cardiac resynchronization-defib

39 pful in selecting patients likely to undergo reverse remodeling after CRT and predicts clinical outco

40 long-term follow-up, responders demonstrated reverse remodeling after CRT with a significant reductio

41 cardial remodeling does not undergo complete reverse remodeling after decreasing afterload.

42 tructural abnormalities of the myocardium or reverse remodeling after LVAD support.

43 HR provides a unique therapeutic approach to reverse remodeling after MI.

44 dysfunction, and suboptimal postoperative LV reverse remodeling after tricuspid valve surgery in comp

45 ces in HF or death risk and in the degree of reverse remodeling among comorbidity groups.

46 l motion delay (SPWMD) would predict greater reverse remodeling and an improved clinical response in

47 hat LBBB and QRS prolongation are markers of reverse remodeling and clinical benefit with CRT in mild

48 eeded to examine if these differences impact reverse remodeling and clinical outcomes after intervent

49 vanced heart failure symptoms and/or adverse reverse remodeling and CRT implanted >6 months underwent

50 ng (<97%), with reduced CRT efficacy by less reverse remodeling and higher risk of HF/death and VTA.

51 on therapy results in atrial and ventricular reverse remodeling and improved hemodynamics.

52 with pre-existing LV dysfunction demonstrate reverse remodeling and improved LV ejection fraction aft

53 eft ventricular assist device (LVAD) exhibit reverse remodeling and in some cases recover from heart

54 Elevated GDF-15 correlates with lack of reverse remodeling and increased mortality after TAVR an

55 are critical predictors of left ventricular reverse remodeling and long-term prognosis in DCM.

56 een serial measurements of functional MR and reverse remodeling and outcomes in patients undergoing C

57 ing cardioprotection and PDE5Is also promote reverse remodeling and reduce myocardial apoptosis, fibr

58 nd/or functional (4 chambers) cardiac cavity reverse remodeling and reduce severity of functional reg

59 d specific pharmacological therapy to induce reverse remodeling and regular testing of underlying myo

60 erate systolic and diastolic performance, to reverse remodeling and restore electric stability and me

61 RS prolongation, and LVEF >30%, CRT produced reverse remodeling and similar clinical benefit compared

62 urpose of this study was to evaluate cardiac reverse remodeling and temporal changes in heart failure

63 ay act to limit atrophy and apoptosis during reverse remodeling and to promote repair and regeneratio

64 on and vascular remodeling that have led to "reverse-remodeling" and regenerative strategies as novel

65 a about changes in cardiac function (cardiac reverse remodeling) and heart failure indices after tran

66 AR blockers reduced left ventricular volume (reverse remodeling) and restored beta-agonist response i

67 improved left ventricular function, induced reverse remodeling, and decreased scar size.

68 phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF.

69 nal pro-B-type natriuretic peptide), cardiac reverse remodeling, and health status scores were compar

70 duction, reduced ventricular interaction, LV reverse remodeling, and improved longitudinal biventricu

71 s the biology of cardiac remodeling, cardiac reverse remodeling, and myocardial recovery with the int

72 This treatment initiates LV reverse remodeling, and provides clinical improvement du

73 this pathway may thus serve as an attractive reverse remodeling approach.

74 2 phenomena and that myocardial recovery and reverse remodeling are not synonymous.

75 (provided to LV and right ventricle [RV]) to reverse remodeling are not understood.

76 t improve, and the electric requirements for reverse remodeling are unclear.

77 loading and normalized biochemical milieu to reverse remodeling are unknown.

78 t ventricular function, and left ventricular reverse remodeling as their counterparts.

79 Reverse remodeling associated with CRT-D therapy was sug

80 Structural and functional reverse remodeling associated with LVADs continues to in

81 resulted in major structural and functional reverse remodeling at 1 year, with the greatest changes

82 this analysis was to determine the extent of reverse remodeling at 12 months after successful percuta

83 significant differences in left ventricular reverse remodeling at 2 years.

84 redictor of a lower rate of left ventricular reverse remodeling at follow-up.

85 HFrEF with a higher rate of left ventricular reverse remodeling at follow-up.

86 lic volume [ESV; P<0.01]), but shunt closure reversed remodeling at 3 months, with end-diastolic volu

87 6 months indicates a break point after which reverse remodeling becomes significantly less pronounced

88 nly LAV or LVESV), and 206 (38%) with lesser reverse remodeling (below-median LAV and LVESV change).

89 Furthermore, NFLG patients experienced less reverse remodeling but the same symptomatic benefit.

90 reasingly consider therapies that facilitate reverse remodeling by directly targeting the heart itsel

91 AP regression and reverse remodeling can be detected accurately by MRI 6 m

92 mbined assessment of factors associated with reverse remodeling can be used for improved selection of

93 otatercept as a disease-modifying agent with reverse-remodeling capabilities.

94 ove functional capacity and left ventricular reverse remodeling compared with CABG alone.

95 k for HF and death in patients with complete reverse remodeling compared with discordant reverse remo

96 cts of left ventricular assist device (LVAD) reverse remodeling could be independent of hemodynamic f

97 echocardiographic score for prediction of LV reverse remodeling (defined as >/=15% reduction in the L

98 Patterns of reverse remodeling differ from lone AS to AS-ATTR, with

99 However, reverse remodeling does not always equate with clinical

100 Clinical implications of complete left-sided reverse remodeling due to cardiac resynchronization ther

101 th the use of the ECG accurately predicts LV reverse remodeling during cardiac resynchronization ther

102 ohormonal factors underlying other facets of reverse remodeling during LVAD support.

103 play a role in the pathophysiology of HF and reverse remodeling during mechanical support.

104 ubitril/valsartan did not have a significant reverse remodeling effect compared with valsartan.

105 CRT exerts pronounced reverse remodeling effects on the left atrium that indep

106 sets of patients whose hearts have undergone reverse remodeling either spontaneously or after medical

107 le analysis, right atrial and/or left atrial reverse remodeling exclusively correlated with intervent

108 ned with pharmacological therapy to maximize reverse remodeling, followed by the beta2 adrenergic ago

109 ection fraction < or =35%) for predictors of reverse remodeling (> or =10% reduction in end-systolic

110 Patients with complete left-sided reverse remodeling had a significantly lower rate of HF

111 D patients with LBBB and complete left-sided reverse remodeling had a significantly lower risk of HF

112 Reverse remodeling has been identified as the primary me

113 ve worsening of cardiac function, slowing or reversing remodeling has only recently become a goal of

114 with discordant reverse remodeling or lesser reverse remodeling (hazard ratio: 0.66 per each group; 9

115 could improve cardiac performance and induce reverse remodeling in a model of established HF, the spo

116 We aimed to characterize reverse remodeling in AS-ATTR and compared with lone AS.

117 rcise capacity and promotes left ventricular reverse remodeling in asymptomatic or minimally symptoma

118 ction improvement precedes right ventricular reverse remodeling in clinical responders to CRT.

119 ew York Heart Association class and promotes reverse remodeling in CRT nonresponders.

120 er time and is associated with the extent of reverse remodeling in observational cardiac resynchroniz

121 of this study was to identify the extent of reverse remodeling in our kidney transplant population a

122 We examined LA reverse remodeling in patients supported with LV assist

123 f the molecular basis of factors influencing reverse remodeling in patients with heart failure.

124 perties can be harnessed to both prevent and reverse remodeling in the ischemically injured ventricle

125 >20% of CRT-D patients exhibited discordant reverse remodeling in the left ventricle and the left at

126 When beta-blockers produce reverse-remodeling in idiopathic dilated cardiomyopathy,

127 Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunc

128 l Evaluation II], REVERSE [Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunc

129 REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunc

130 sfunction, outcomes in the REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunc

131 ization Therapy], REVERSE [Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunc

132 , completely restores function and partially reverses remodeling, including normalization of the hype

133 ode of intervention did not affect degree of reverse remodeling, indicating that both are effective a

134 Thus, reverse remodeling is associated with a specific pattern

135 (LV) reverse remodeling with CRT or whether reverse remodeling is modified by the cause of heart fai

136 We hypothesized that reverse remodeling is predicted by the left bundle branc

137 tudy was to further test the hypothesis that reverse-remodeling is associated with favorable changes

138 onnaire-23 scores, and parameters of cardiac reverse remodeling (left ventricular EF, indexed left at

139 The secondary end point was left ventricular reverse remodeling (left ventricular ejection fraction i

140 Spironolactone induced reverse remodeling (left ventricular mass index declined

141 ratio on the association between sex and LV reverse remodeling (LV end-systolic volume change) and s

142 sy (EMB) results to predict left ventricular reverse remodeling (LVRR) in individuals with recent-ons

143 Left ventricular reverse remodeling (LVRR) was defined as the composite o

144 cular arrhythmia (MVA), and left ventricular reverse remodeling (LVRR).

145 y the myocardial energetic dysregulation in (reverse) remodeling, mainly focusing on the mitochondria

146 Reverse remodeling may be attributable to a reversal of

147 Our results suggest that reverse remodeling may involve selective, rather than gl

148 improved functional capacity and evidence of reverse remodeling; more recently, CRT has been associat

149 main outcomes measured were left ventricular reverse remodeling, mortality, heart failure hospitaliza

150 mprove functional capacity, left ventricular reverse remodeling, MR severity, and B-type natriuretic

151 Patients with reverse remodeling (n = 211, 42%) had a lesser extent (p

152 le range, 0%-1% vs 0%-4%) than those without reverse remodeling (n = 296, 58%) (P < .001 in pairwise

153 LV reverse remodeling (n=161; 48%) was associated with pre-

154 ling; (2) its absence can cause beta-blocker reverse remodeling nonresponse; and (3) when from HCN4 c

155 smaller hearts contributes, in part, to more reverse remodeling observed in women after cardiac resyn

156 in the pathogenesis of heart failure and in reverse remodeling observed with mechanical support.

157 ersus 61.9+/-6.8%; P<0.01), and right atrial reverse remodeling occurred (pPVR versus mPVR, 15.2+/-3.

158 her QRS scores for LV scar predicted reduced reverse remodeling (odds ratio [confidence interval]=0.4

159 activation time predicted increased odds of reverse remodeling (odds ratio [confidence interval]=1.3

160 Progressive reverse remodeling of all cardiac chambers was observed.

161 2 years of follow-up, atrial shunting led to reverse remodeling of left-sided chambers and increases

162 heart failure (HF) can result in beneficial reverse remodeling of myocardial structure and function.

163 of neurohormonal environment in determining reverse remodeling of the beta-adrenergic pathway.

164 f coronary atherosclerosis is accompanied by reverse remodeling of the EEM, resulting in no change in

165 ft ventricular assist devices (LVADs) induce reverse remodeling of the failing heart except for the e

166 ht guide future studies of unloading-induced reverse remodeling of the failing human heart.

167 fects of VAD support and cell therapy on the reverse remodeling of the failing myocardium and to disc

168 ommunity because of its potential to augment reverse remodeling of the failing myocardium.

169 and mass and reduce mitral regurgitation by reverse remodeling of the failing ventricle.

170 r, and genomic research that accompanies the reverse remodeling of the human heart in response to a l

171 In the MADIT-CRT study, favorable reverse remodeling of the left atrium with CRT-D therapy

172 py have been recently demonstrated to induce reverse remodeling of the left ventricle and may improve

173 ular dyssynchrony who respond to CRT without reverse remodeling of the LV.

174 In AS patients after AVR, reverse remodeling of the supranormal systolic function

175 PVA polymer injection resulted in acute reverse remodeling of the ventricle with papillary muscl

176 T, we found a remarkable and almost complete reverse remodeling of these structures despite persisten

177 art failure symptomatology and in some cases reversed remodeling of the cardiac dysfunction.

178 r hypertrophy is a major contributor to the "reverse remodeling" of the heart after LVAD implantation

179 eometry, the pathological mechanisms of the "reverse remodeling" of the heart are unknown.

180 and their association, and the impact of LA reverse remodeling on all-cause mortality, LVAD-related

181 However, the effect of reverse remodeling on APD during cardiac resynchronizati

182 and predictive value of complete left-sided reverse remodeling on heart failure (HF) and death event

183 >130 ms, the test characteristics to predict reverse remodeling or a clinical response were inadequat

184 The previous findings that SPWMD predicts reverse remodeling or clinical improvement with CRT were

185 reverse remodeling compared with discordant reverse remodeling or lesser reverse remodeling (hazard

186 te of HF or death than those with discordant reverse remodeling or lesser reverse remodeling (p < 0.0

187 o significant difference in left ventricular reverse remodeling or survival at 12 months between pati

188 between-group difference in left ventricular reverse remodeling or survival at 2 years.

189 e clinical characteristics, left ventricular reverse remodeling, or outcomes on multivariable analysi

190 al symptoms and significant left ventricular reverse remodeling over 12 months.

191 with discordant reverse remodeling or lesser reverse remodeling (p < 0.001).

192 e at follow-up (P=0.002) and right ventricle reverse remodeling (P<0.001).

193 nts in clinical composite response (P=0.02), reverse remodeling parameters, and time to death or firs

194 >/=0.1% ectopic beats had significantly less reverse remodeling (percent reduction in LVESV 31 +/- 15

195 Predicted probability of reverse remodeling ranged from <20% for patients with ad

196 dical therapies for heart failure related to reverse remodeling, remission, and recovery are discusse

197 achieved left ventricular ejection fraction reverse-remodeling response defined as improvement by >/

198 The profound reverse remodeling routinely associated with left ventri

199 between acute hemodynamic response (AHR) and reverse remodeling (RR) in cardiac resynchronization the

200 LV reverse remodeling (RR) was defined as an increase in LV

201 associated with spontaneous left ventricular reverse remodeling (S-LVRR) among mildly symptomatic hea

202 ased over time as the LV became smaller, and reverse remodeling slowed.

203 Significant right heart structural reverse remodeling takes place immediately after PVR, fo

204 re MR before CRT experienced relatively more reverse remodeling than patients with lesser degrees of

205 During reverse remodeling, the concomitant attenuation of cardi

206 (39%) patients with initial left ventricular reverse remodeling, there was a subsequent left ventricu

207 use of the terms "myocardial recovery" and "reverse remodeling" to describe the reversal of various

208 Reverse remodeling trended better with MPP-AS programmin

209 Reverse remodeling was assessed by comprehensive evaluat

210 dysfunction enrolled in the MADIT-CRT trial, reverse remodeling was associated with a significant red

211 The magnitude of LA reverse remodeling was associated with all-cause mortali

212 A part of the female advantage regarding reverse remodeling was attributed to the larger QRSarea/

213 A part of the female advantage regarding reverse remodeling was attributed to the larger QRSarea/

214 Reverse remodeling was defined as a decrease in left ven

215 Reverse remodeling was defined as reduction in LV end sy

216 Reverse remodeling was measured as reductions in atrial

217 Reverse remodeling was measured by left ventricular ejec

218 Left ventricular reverse remodeling was more common in patients with nong

219 LV reverse remodeling was observed in DCM -MWHE and in ICM

220 ile or continuous devices; the degree of the reverse remodeling was similar in both ventricles, altho

221 Moreover, the potential role of ACT in reverse remodeling was studied in detail.

222 echniques, the only independent predictor of reverse remodeling was the presence of simultaneous none

223 The independent predictors of reverse remodeling were infarct size (odds ratio, 0.98;

224 Predictors of reverse remodeling were nonischemic etiology, female sex

225 l improvement and signs of right ventricular reverse remodeling were observed.

226 ry to beta-blockade for both HR lowering and reverse remodeling were randomized 2:1 double-blind to t

227 trial electrical and anatomic remodeling and reverse remodeling were studied in a canine model of chr

228 3 measurements in functional MR demonstrates reverse remodeling when MR severity is reduced to either

229 cardiographic score allowed prediction of LV reverse remodeling with a sensitivity of 84% and a speci

230 heart failure exhibit left ventricular (LV) reverse remodeling with CRT or whether reverse remodelin

231 Treatment with an aim to halt or reverse remodeling with mainly two classes of medication

232 Reverse remodeling with reduced systolic wall stress and

233 cular pacing alone, indicating no systematic reverse remodeling with right ventricular pacing.

234 recurrent mitral regurgitation, and improved reverse remodeling without adverse effect on left ventri