ライフサイエンスコーパス: reversion

1 confirms causality through mutant phenotype reversion.

2 pon removal dramatically accelerates thermal reversion.

3 quent active tuberculosis disease and of QFT reversion.

4 Notch signaling, which promotes neuron-to-NB reversion.

5 ion with visible light accelerates the shape reversion.

6 diate restart of transfusions in the case of reversion.

7 -expression of PTEN resulted in a phenotypic reversion.

8 or by temperature-dependent nonphotochemical reversion.

9 12% of viruses and still binds MPER after DJ reversion.

10 mutations along genetic pathways to AA-to-DE reversion.

11 at profound fitness barriers prevent motif I reversion.

12 timates of the activation parameters for the reversion.

13 more accessible and beneficial than partial reversion.

14 identify multiple impediments to MHV-ExoN-AA reversion.

15 ing of oral dysbiosis and its prevention and reversion.

16 ide insight into the biology of pathogenesis reversion.

17 are also affected by light-independent dark reversion.

18 say, which exhibits frequent conversions and reversions.

19 nity to study the dynamics of CTL escape and reversion after transmission in the light of shared and

20 ltiple independent reversions indicated that reversion-allele frequency in metastatic sites is an imp

21 uding two patients with multiple independent reversion alleles.

22 t light qualities by regulation of phyB dark reversion, allowing plants to adapt growth and developme

23 consequence, we observe both a lower rate of reversion and a lower probability that reversion to sens

24 eage conversion, pluripotency-to-totipotency reversion and cancer.

25 platinum-resistant models, including BRCA1/2 reversion and CCNE1-amplified models, correlate with syn

26 limitations of MLV with no risk of virulence reversion and emergence of new virulent serotypes.

27 1 GPC, we hope to minimize the likelihood of reversion and enhance safety in a second-generation Cand

28 nd F427I thus may minimize the likelihood of reversion and enhance safety in a second-generation Cand

29 ed to a more pronounced global transcriptome reversion and normalized T(H)17 cell/IL23 signaling, whe

30 s this function of phyB by accelerating dark reversion and thus depletion of Pfr forms in the night.

31 (IPUint) was found to be responsible for IPU reversion and was identified as a hydroperoxyl derivativ

32 We reveal that extensive epistasis prevents reversions and necessitates fixation of new mutations, l

33 alyzed to determine the rates of positivity, reversion, and conversion in serial testing data.

34 as plasticity, de- and transdifferentiation, reversion, and paligenosis were discussed.

35 f variation that include parallel evolution, reversion, and recombination, compromising phylogenetic

36 t to basic research on vaccines, attenuation reversion, and replication.

37 th engineered nucleases, genomic inversions, reversions, and deletions of short nucleotide expansions

38 The rates of reversion are of the same order of magnitude as spontane

39 ecreases in drug-dependent killing; however, reversion back to a fully drug-susceptible large-colony

40 ed for cell differentiation can also promote reversion back to a naive pluripotent cell state.

41 erization interfaces is critical for thermal reversion back to the resting state.

42 y irradiation with UV light and the expected reversion by either heating or irradiation with visible

43 To test whether reversion by recombination between UBE2T AluYa5 elements

44 At least a partial phenotypic reversion can be achieved by suppression of p38 and ERK1

45 r attenuating nucleotides and confirmed that reversion can occur in days to weeks after vaccination.

46 ma levels of alpha-defs, caused a phenotypic reversion characterized by smaller thrombi comparable to

47 We investigated whether reversions contributed to the variable disease expressio

48 nd little evidence for the occurrence of CTL reversions, CTL escape processes were found to be highly

49 fatigue (38%) after four irradiation-thermal reversion cycles.

50 All patients with reversions detected in tumor-derived DNA were resistant

51 d may alter the genetic background to render reversion detrimental to fitness.

52 Our results suggest genetic reversion due to cisplatin-induced mutations as a distin

53 during 1990-2000 of 213.65 km(2)/year, and a reversion during 2000-2015 with a net decrease of 251.58

54 replication, often leading to wild-type (WT) reversion during complementation of replication-defectiv

55 ontacts, also plays an important role in the reversion dynamics.

56 overexpression of CCN5 in SP results in EMT reversion, ER-alpha upregulation and delays in tumor gro

57 In developed countries, high rates of reversion following conversion have been described.

58 The barrier to reversion for this adduct is relatively insensitive to c

59 We describe the mechanism of reversion for this strain and for a second clinical isol

60 The heating-induced reversion from [am + alpha-Al + multicomponent AlxMy] to

61 s certain benefits of sexual specialisation, reversion from a strategy of separate sexes to one of co

62 ties are likely to be maintained through the reversion from cells with intermediate transcription act

63 We report the first clearly defined case of reversion from methicillin susceptibility to methicillin

64 vation needs to be continually sustained, as reversion from senescence occurs rapidly with aggressive

65 perception through its temperature-dependent reversion from the active Pfr state to the inactive Pr s

66 nderstanding of the impact of CTL escape and reversion from the founder virus in HIV infection and co

67 imary immunodeficiency diseases (PIDs) where reversions have been described also revealed a higher ra

68 n evolutionary rationale for lack of ExoN-AA reversion, illuminate potential multiprotein replicase i

69 AF reversion in conscious long-term tachypaced pigs: Pigs w

70 These rescue effects are attributed to a reversion in EC morphological changes, such as cell size

71 rns of segregation in mouse experiments, and reversion in human stem cells.

72 essible pathway to increase fitness in rCan, reversion in K33S-GPC rCan is likely to be lethal.

73 5'-untranslated region, the primary site of reversion in Sabin OPV.

74 of gastric cancer cells, with a significant reversion in the expression level of metastatic markers.

75 genes leads to a vegetative-to-reproductive reversion in the inflorescence, a phenomenon that has no

76 l culture conditions that readily select for reversion in the parental rCan virus.

77 of infection was 7.3%, whereas inclusion of reversions in the analysis showed that the actual risk o

78 topsy of a patient with multiple independent reversions indicated that reversion-allele frequency in

79 tants is caused by an inactivating lesion in reversion-inducing cysteine-rich protein with Kazal moti

80 Here we show that the membrane protein RECK (Reversion-inducing cysteine-rich protein with kazal moti

81 luciferase assays and Western blot analysis, reversion-inducing cysteine-rich protein with kazal moti

82 Drug holidays at the IDTC state allow for reversion into parental cells re-sensitizing them to the

83 n populations reveals admixture and cultural reversion involving several Khoesan groups, and highligh

84 oint bioactivity at locations and times when reversion is a dominant trenbolone fate pathway.

85 Dark reversion is a temperature-dependent thermal relaxation

86 This reversion is highly efficient and synchronized, with mor

87 e find that, in all solvents, the barrier to reversion is larger for the adduct formed with N-methylm

88 Because reversion is not observed with other disease-causing ker

89 We show that ExoN-AA reversion is possible but evolutionarily unfavorable.

90 These results demonstrate that while reversion is possible, at least one alternative adaptive

91 for conversions (kappa = 0.74), but poor for reversions (kappa = 0.12).

92 The reversion likely occurred in a prethymic T-cell precurso

93 e partial attenuation mutations and a single reversion mutation is less likely to cause a reversion t

94 Our findings indicate that a single reversion mutation will less likely cause a major revers

95 Surprisingly, BRCA reversion mutations and an ability to form RAD51 foci ar

96 However, strain MP-12 with reversion mutations at those 3 sites was still highly at

97 Conclusion Reversion mutations can be detected in an unbiased analy

98 goal of this study was to determine whether reversion mutations could be found in an unbiased manner

99 Elbow region reversion mutations in a glycan-V3 bnAb modestly reduces

100 In a CD4-binding site lineage, reversion mutations result in a loss of neutralization p

101 Reversion mutations were only detected in tumor samples

102 cient tumour cells that do not develop Brca2 reversion mutations.

103 combination (HR), which can result from BRCA reversion mutations.

104 in-resistant clones did not harbor secondary reversion mutations; rather, PARPi and platinum resistan

105 However, secondary intragenic (reversion) mutations that restore protein function lead

106 uth, and Central Asia) could necessitate the reversion of 20-60 Mha of cropland from irrigated to rai

107 Reversion of 38T/F/M to I38-WT was rare among influenza

108 Reversion of 5-HT7 blockade was performed by intraperito

109 indirect, multi-step process that ends with reversion of 5mC to unmodified cytosine.

110 Importantly, naive reversion of a broad repertoire of conventional hiPSCs r

111 Adult F cells might represent a reversion of a given cell to a fetal-like epigenetic and

112 nitial designs failed to fold correctly, but reversion of a small number of mutations indicated by ba

113 leading to inhibition of self pollen or for reversion of A. thaliana to its fully self-incompatible

114 We observed that reversion of amino acid 375 to a serine (H375S) resulted

115 psychomotor development, along with dramatic reversion of biochemical abnormalities.

116 s restored in advanced prostate cancers upon reversion of both repressive signals.

117 ion in cells bearing chimpanzee CD4 requires reversion of both threonines at sites 34 and 68, destroy

118 Genetic reversion of BRCA1-inactivating mutations can be the und

119 tin-specific mutation types as causes of the reversion of BRCA2 mutations in emerging cisplatin-resis

120 , cisplatin-resistant clones lacking genetic reversion of BRCA2 show de novo loss of CHD4 expression

121 , in vitro and in vivo, results in long-term reversion of CAF-associated proinvasive activity and res

122 We document the reversion of CGD inflammatory status by the mammalian ta

123 ating mouse heart revealed a transcriptional reversion of CM differentiation processes, including rea

124 A germline reversion of CV30 results in a substantial reduction in

125 We evaluated phenotypic reversion of deoptimized human respiratory syncytial vir

126 effects in vitro and in vivo, including the reversion of EMT, the loss of TIC-mediated clonogenic co

127 We found that it induces reversion of epithelial to mesenchymal transition.

128 rge (i.e., compensatory substitutions versus reversion of existing attenuating mutations).

129 Finally, engineered reversion of ExoN-AA to ExoN-DE in the presence of ExoN-

130 replication and competitive fitness without reversion of ExoN-AA.

131 we identified a prominent hydrophobic patch; reversion of four hydrophobic residues in this patch to

132 throid differentiation program, leading to a reversion of gamma-globin silencing in adult human eryth

133 Widespread reversion of genetic disease is rare; however, such even

134 traction, MV collapse to GMP, and subsequent reversion of GMP to normal microvessels, all without ext

135 We attempted site-specific reversion of hSH3BGRL amino-acid sequence to mSH3BGRL an

136 Reversion of hydrophobic residues in these patches to th

137 malized blood phenylalanine concomitant with reversion of hypopigmentation in a dose-dependent manner

138 lung metastasis, and suggest that epigenetic reversion of IRX1 activation may be beneficial for contr

139 In addition to rapid reversion of key attenuating mutations, we identify stro

140 As with KRT10 mutations causing IWC, reversion of KRT1 mutations occurred via mitotic recombi

141 To assess the dynamics of genetic reversion of live poliovirus vaccine in humans, we studi

142 sensitivity but did reduce the frequency of reversion of macrodomain mutants.

143 This allows the reversion of mitophagy failure reflected in the recovery

144 Strikingly, after reversion of motor neuron identity, virtually all firing

145 pervasiveness of sign epistasis--a complete reversion of mutational effects, particularly in protein

146 is method facilitates efficient induction or reversion of mutations associated with human disease in

147 o the vacuole, providing a rationale for the reversion of nramp3nramp4 phenotypes.

148 that inhibit or promote photoconversion and reversion of Pfr back to Pr, thus allowing Phys to dynam

149 ight-absorbing Pg states, as well as thermal reversion of Pg back to Pb.

150 Reversion of Phe(87) to tyrosine abolished GABA's inhibi

151 the outcome of global DNA demethylation with reversion of primed PSCs to the naive ground state, we u

152 orax and is necessary and sufficient for the reversion of root growth inhibition.

153 ormin, and insulin to assess for appropriate reversion of specific diabetogenic genes.

154 Results showed the successful in vitro reversion of such an activity by perturbation of in sili

155 Reversion of such epigenetic variants occurred rarely, r

156 ditors (CBEs) enable efficient, programmable reversion of T*A to C*G point mutations in the human gen

157 In many cases, full reversion of the Ab-framework mutations back to germline

158 he hypothesis that the origin and subsequent reversion of the B(1) duplication are mediated by unequa

159 n suppressors of mpk4, resulted in a partial reversion of the CA-MPK3 phenotypes.

160 A biosynthesis or JA signaling led to a full reversion of the cpk28 growth phenotype, while modificat

161 This is indicative of reversion of the framework to the wide-channel form unde

162 tions achievable in human subjects, caused a reversion of the gene expression profile in multiple scl

163 ines to a demethylating agent caused partial reversion of the High-M phenotype and inhibition of prol

164 ls, and 5 passages in MDCK cells revealed no reversion of the I221L substitution.

165 ome patient T cells was associated with both reversion of the inactivating mutation and a variant wit

166 ant in pigs three times and did not find any reversion of the introduced mutations.

167 Reversion of the K65R increased susceptibility to tenofo

168 Reversion of the keratin intermediate filament fragility

169 MAPREC measures reversion of the main OPV attenuating mutations such as

170 Although reversion of the mutation at residue 291 or 295 from tha

171 This resulted in reversion of the mutation in 10% (6.7-20.1%) of hepatocy

172 vement originated from a spontaneous genetic reversion of the MYSM1 mutation in a hematopoietic stem

173 lated GSIS, was associated with a remarkable reversion of the normal AMPK-dependent adult beta-cell s

174 -versus-host disease occurred only following reversion of the orf-I initiation codon mutation within

175 ulation of TCV in conjunction with a partial reversion of the primary mutation (TCV-rev1) but had neu

176 kinetics experiments, we determined that the reversion of the quadricyclanes occurs via a free radica

177 ty to tenofovir and other nucleosides, while reversion of the T69del showed increased resistance to z

178 shRNAi lentivirus (shR-SOCS1) led to partial reversion of the tumorigenic phenotype of B16F10-Nex2 me

179 vening color marker gene, recapitulating the reversion of the UBE2T duplication in the FA patient.

180 eloped TFH cells back to the T cell zone and reversion of their phenotype to non-TFH effector cells,

181 h acquired resistance to OXA, leading to the reversion of their resistant phenotype, through the inhi

182 Reversion of these CD9 changes abolished the effects of

183 Partial reversion of these phenotypes when traces of active comp

184 ute to their progression to HCC and that the reversion of this condition may represent a possible the

185 Conversely, full reversion of virulence of BTV8H required at least five g

186 many recurring deletions, more specifically, reversions of an ancient hominin-specific duplication of

187 rs' relative abundances may frequently drive reversions of generalist mutualisms to autonomy.

188 d resistance, including multiple independent reversions of germline BRCA1 or BRCA2 mutations in indiv

189 None of these mutations were reversions of ML29 to the sequences of the parental Lass

190 in wild-type E. coli, and thus would require reversion or compensation once a sufficient new activity

191 e underlying germline deficit through direct reversion or indirect compensation, whereas others do so

192 only initial sputum culture conversion, not reversion or long-term relapse.

193 s strongly inversely associated with risk of reversion (P < 0.0001).

194 odelled a newly discovered product-to-parent reversion pathway for trenbolone acetate (TBA) metabolit

195 This novel reversion phenomenon is encouraging for obtaining the [a

196 served polymerase motif A because of the low reversion potential inherent in the single UGG codon.

197 Reversion, predicted by baseline reticulocyte count >/=4

198 nonical mutations associated with phenotypic reversion present at high levels (>90%).

199 e applied a computationally guided framework-reversion procedure to two broadly neutralizing anti-HIV

200 degrees than wild-type cry1, and has a dark reversion rate 1.7 times lower than that of the wild typ

201 ate was 0.8% (range, 0.0-2.5%), and the mean reversion rate was 17.6%.

202 Reversion rates depend strongly on conservation.

203 high rates of positivity and high conversion/reversion rates on retesting.

204 ST conversion concordance was higher and QFT reversion rates were lower than reported in low-burden s

205 paths of differentiation and undergo lineage reversion, respectively, during regeneration.

206 ytochrome B (phyB) and suppress phyB thermal reversion, resulting in plants with dramatically enhance

207 ng proteins PCH1 and PCHL suppress phyB dark reversion, resulting in plants with dramatically enhance

208 synonymous modifications to the genome, the reversion risk is significantly reduced, rendering the v

209 QFT reversion risk was inversely associated with interferon-

210 risks were 14.0 and 13.0%, respectively, and reversion risks were 5.1 and 4.1%, respectively.

211 se design did not rely on prior knowledge of reversion sequences.

212 lts in a greater propensity for 17alpha-TBOH reversion than 17beta-TBOH.

213 ing PBs and as a direct regulator of thermal reversion that is sufficient to stabilize phyB as Pfr in

214 B2-T271A, PB2-D701N, HA-V195I, and PB2-E627K reversion) that may enhance viral replication in pigs.

215 into PhyB confers robust Pfr --> Pr thermal reversion, that assembled with the cyanobacterial versio

216 in cfDNA from patients with a tumor-detected reversion (three of five).

217 cell fates is more probable and feasible via reversion to a developmentally immature state.

218 efractoriness to key metabolic hormones, and reversion to a fetal-like gene expression pattern.

219 Loss of XOR then results in a reversion to a more rudimentary, less efficient, apocrin

220 Such changes are consistent with reversion to a more stem-like state upstream of cancerou

221 resent another form of tumor plasticity with reversion to a neural crest cell migratory phenotype.

222 ition of STAT3 or SMAD3 resulted in a marked reversion to a non-invasive, epithelial phenotype.

223 nt basal-like cell lines, and decreased upon reversion to a nonmalignant phenotype.

224 Reversion to a quiescent NK-cell phenotype was associate

225 lls (hiPSC) can be significantly improved by reversion to a tankyrase inhibitor-regulated human naive

226 the potential for infections arising from a reversion to a virulent form in live pathogens, unproduc

227 fusions restarted immediately in the case of reversion to abnormal velocities.

228 Lentiviral knockdown of MBNL3 resulted in reversion to an embryonic alternative splice isoform pro

229 In summary, MBNL3 down-regulation-related reversion to an embryonic alternative splicing program,

230 The regenerative transcriptome represents a reversion to an embryonic transcriptional state of the C

231 tasis is dependent on the ability to undergo reversion to an epithelial phenotype in a process known

232 unction during heart failure (HF) reflects a reversion to an immature phenotype.

233 ine candidate in chicken eggs can select for reversion to avian receptor preference.

234 using zero-error-clamp trials has shown that reversion to baseline is not obligatory and can be overc

235 as interplay between learning from error and reversion to baseline, a form of forgetting.

236 nsitivity of eer5-1 and are at least in part REVERSION TO ETHYLENE SENSITIVITY 1 (RTE1)-dependent, er

237 n in adults induced severe heart failure and reversion to fetal splicing and gene expression patterns

238 We developed a fluctuation test based on reversion to fluorescence in a set of virally encoded mu

239 de an escape from specialist pollination via reversion to more generalist pollination strategies.

240 that occurs in pre-implantation embryos and reversion to naive ground state pluripotent stem cells (

241 Nonetheless, WNT induces reversion to naive pluripotency.

242 lopment (when Celf1 is downregulated) show a reversion to neonatal splicing patterns after Celf1 re-e

243 Reversion to neurovirulence, assessed as paralysis of tr

244 ble than existing OPVs, with a lower risk of reversion to neurovirulence.

245 onths times 2, then annually unless there is reversion to nondysplastic Barrett's esophagus.

246 origin, served as an intermediary step in MV reversion to normal microvessels.

247 Reversion to normal rhythm was associated with QT prolon

248 Large carnivore management in Alaska is a reversion to outdated management concepts and occurs wit

249 ic pH, which is the only condition where its reversion to parent TBA metabolite occurred.

250 ainst further infection, and had low risk of reversion to pathogenic phenotypes.

251 for attenuation raise the prospect of facile reversion to pathogenicity.

252 henotype is modulated by NUC therapy and its reversion to quiescence mirrors efficient HBV-specific T

253 te of reversion and a lower probability that reversion to sensitivity on the population level occurs

254 There are likely differing timescales for reversion to susceptibility across organisms and antibio

255 observed across all dosage regimens; partial reversion to susceptibility was observed in 6 of 8 bacte

256 Reversion to the 'dry seed' state of DNA methylation upo

257 We conclude that phenotypic reversion to the antibiotic-sensitive state can be media

258 is coincides with their facilitation of UVR8 reversion to the ground state by redimerization and thei

259 instead result in mtDNA genotypic drift and reversion to the original genotype.

260 W480+APC cells, and its depletion results in reversion to the p120-catenin isoform 1A phenotype and r

261 product with visible wavelengths results in reversion to the parent Os(VIII) complex.

262 the molecular tags are highly stable with no reversion to the parental sequence detected in >2 years

263 in creating an evolutionary barrier against reversion to the pathogenic genotype.

264 l dehydration in dark conditions, leading to reversion to the primary cycloaddition photoproduct on a

265 g can lead to a dramatic loss of the CNV and reversion to the progenitor genotype and drug susceptibi

266 mers; purifying selection would then prevent reversion to the unassembled form, even if assembly per

267 CV subpopulation by reducing the rate of SCV reversion to the wild type.

268 of the E182D mutant with IDI-6273 yielded a reversion to the wild-type protein sequence and phenotyp

269 Phenotypic reversion to the wild-type-like NCV state correlated wit

270 e of MLV as a vaccine virus due to the rapid reversion to virulence during replication in pigs.

271 ations responsible for the attenuation of or reversion to virulence during this evolutionary process.

272 However, reversion to virulence has been demonstrated in several

273 sion mutation will less likely cause a major reversion to virulence of the MP-12 vaccine.

274 reversion mutation is less likely to cause a reversion to virulence of the MP-12 vaccine.

275 n live-attenuated viruses that pose risks of reversion to virulence or residual pathogenicity.

276 raising concerns regarding the potential for reversion to virulence.

277 s towards gynodioecy (n = 11), but also many reversions to nongynodioecy (n = 29).

278 hanges in the chimpanzee clade, and all were reversions to the ancestral condition.

279 frequently evolved also have a high rate of reversions to the nongynodioecious state.

280 ATED1, physically interacts with Arabidopsis REVERSION-TO-ETHYLENE SENSITIVITY1 (RTE1), an ethylene r

281 east assay, we found that maize RTE1 homolog REVERSION-TO-ETHYLENE SENSITIVITY1 LIKE4 (ZmRTL4) and Zm

282 signaling protein ETHYLENE-INSENSITIVE2 and REVERSION-TO-ETHYLENE SENSITIVITY1 reside.

283 nt learning process that has the property of reversion toward baseline and that can suppress other fo

284 altered islet-specific T cell phenotype but reversion toward pretransplant profiles over time.

285 Reversion toward the cue direction occurred irrespective

286 Reversions towards the ancestral HIV-1 sequence are obse

287 Increased rates of thermal reversion upon exposing Arabidopsis seedlings to warm en

288 isk was not significantly increased, and QFT reversion was common, following QFT conversion at interf

289 The fastest reversion was demonstrated after 4 months of treatment.

290 However, reversion was found at all mutated sites within five vir

291 The number of patients with culture reversion was lower in those receiving bedaquiline (1 pa

292 solution size, photoconversion, and thermal reversion, we identified both proximal and distal featur

293 Higher degrees of reversion were associated with recombination-mediated re

294 Conversion and reversion were not associated with HIV status.

295 located in genomic islands, although genetic reversions were also observed.

296 ation of 1 individual indicated that somatic reversions were postnatally selected.

297 occurred in 9% (n = 63 of 718), whereas IGRA reversions were seen in 33% (n = 25 of 76) of individual

298 ves under noninductive conditions and floral reversion when shifted from inductive to noninductive co

299 h 50% frequency, followed by an N332-to-N334 reversion, which took 66 weeks.

300 s more stable-leading to a larger barrier to reversion-while the adduct formed with maleic anhydride