ライフサイエンスコーパス: rheostat

1 nal changes; we consider these evolutionary "rheostats".

2 hose in the N-lobe are stiff, analogous to a rheostat.

3 tions as an oxygen-dependent transcriptional rheostat.

4 structural subensembles as a conformational rheostat.

5 how cell specificity is built into the LynA rheostat.

6 lation of mVEGFR1 in its role as a molecular rheostat.

7 this family of two-component systems exhibit rheostat activity that likely confers versatility as mic

8 This class of siRNA may act broadly as a rheostat allowing prolonged stimulation to dampen gene e

9 m of copy number control acts as a molecular rheostat, allowing high levels of retrotransposition whe

10 (3) Although both rheostat and "neutral" (defined when all substitutions e

11 plex, identified as R2/R4 neurons, acts as a rheostat and plays an important role in transducing sens

12 al epithelium and reveal YAP as a protective rheostat and regenerative regulator in the mammalian liv

13 e predictors requires distinguishing between rheostat and toggle positions.

14 Glutamylation acts as a rheostat and tunes microtubule severing as a function of

15 any toggle positions are conserved, and most rheostats are not, predictors appear to annotate positio

16 This Rop signal transduction rheostat balances the ability to increase ethanolic ferm

17 opose that Blimp-1 acts as a transcriptional rheostat balancing effector function and T cell exhausti

18 gesting that the ESL operates as a conserved rheostat between long inverted repeats upstream of each

19 ed IL-9R mutants showed that STAT1 acts as a rheostat between stem-like and effector states.

20 We demonstrate that Bim acts as a molecular rheostat by controlling macrophage function not only in

21 e find that monocytes function as a cellular rheostat by regulating leptin levels and revascularizati

22 Thus, this pathway acts as a 'rheostat' by translating TCR signal strength via graded

23 Most importantly, this rheostat can be reprogrammed experimentally.

24 novators of tissue environments but also the rheostat cells for immune circuits.

25 mide levels could act as a general apoptotic rheostat controlling cell survival by regulating PI(3)K

26 fe, and BIM regulation by miRNAs serves as a rheostat controlling cell survival in specific physiolog

27 rtum, the normalization of the physiological rheostat controlling IFN signaling depends on IFNL3 geno

28 esults suggest that CD31 acts as a molecular rheostat controlling integrin-mediated adhesion at the u

29 MHC-I-bound peptide functions as a molecular rheostat controlling NK cell function.

30 ge itself, miR-223 functions as an important rheostat controlling NLRP3 inflammasome activity.

31 We propose that Rap1 acts as a rheostat controlling nucleotide pools in response to sho

32 r findings implicate eIF5A as a cytoskeletal rheostat controlling RhoA/ROCK protein expression during

33 ulation through REDD1/TXNIP is physiological rheostat controlling stress-induced autophagy.

34 y inactivation serves as a lineage-dependent rheostat controlling the magnitude of the adaptive relie

35 otein Ambra1 as the first described 'spatial rheostat' controlling the Src/FAK pathway.

36 ealing an undescribed function of STIM1 as a rheostat directing the effects of calcium signaling and

37 These results show that the SPHK rheostat does not play a major role in tumor cell viabil

38 missing regulatory link that controls the SL rheostat during the cell cycle.

39 1a acts as an intrinsic antigen sensitivity "rheostat" during T cell development.

40 This model illustrates the complex rheostat dynamics underlying the ABA-induced stress resp

41 findings provide a molecular mechanism for a rheostat effect of increasing or decreasing RANTES expre

42 on epigenetic mark and PRC1.1 as a molecular rheostat fine-tuning Treg adaptability, establishing PRC

43 interplay between Zfp521 and Ebf1 as a novel rheostat for bone homeostasis.

44 Therefore, FGF21 is a critical rheostat for bone turnover and a key integrator of bone

45 ate that hypoxia-inducible mir-210 acts as a rheostat for cellular adaptation and survival by inhibit

46 acellular proteins and serves as a metabolic rheostat for cellular stress.

47 These findings identify a cell-intrinsic rheostat for destabilizing ground-state pluripotency to

48 a model wherein tumor eHsp90 functions as a rheostat for EZH2 expression and activity to orchestrate

49 ted molecules with the potential to act as a rheostat for fetal Vdelta2 cells.

50 karyotic genome, has emerged as a sensor and rheostat for fluctuating intracellular metabolites.

51 rotein homeostasis serves as a physiological rheostat for hematopoietic stem cell fate and function.

52 In summary, we identified IFN-k as a rheostat for initiation of psoriasiform inflammation.

53 In summary, we identified IFN-kappa as a rheostat for initiation of psoriasiform inflammation.

54 the notion of the existence of a biological rheostat for lymphocyte homing.

55 uences, but can also function as a molecular rheostat for maintaining oncogene expression at optimal

56 C1-Plzf functional interaction as a critical rheostat for maintenance of the spermatogonial pool and

57 In vivo, ARF3 levels acted as a rheostat for metastasis from intraprostatic tumor transp

58 energy supply/demand and thereby, serve as a rheostat for mitochondrial nutrient utilization.

59 RNMT, allowing it to function as a molecular rheostat for mRNA cap methylation.

60 ents, we found that PGE2 signaling acts as a rheostat for muscle stem-cell function.

61 novel MYC ubiquitin ligase and an endogenous rheostat for MYC activity.

62 Thus, GBP5 serves as a unique rheostat for NLRP3 inflammasome activation and extends o

63 182's gene silencing activity functions as a rheostat for PDFR signaling and thus profoundly impacts

64 RasGTP-SOS feedback loop that functions as a rheostat for Ras activity.

65 of SHP-1 abundance by TAOK3 thus serves as a rheostat for TCR signaling and determines the activation

66 and argue that Sox2 functions as a molecular rheostat for the control of a key transcriptional regula

67 ose--has evolved in eukaryotes to serve as a rheostat for the Hsp90 chaperone machine.

68 itor of apoptosis (XIAP) acts as a molecular rheostat for the immune deficiency (IMD) pathway of the

69 HP-1 competition for Ly108 ITSM binding as a rheostat for the magnitude of T cell help to B cells.

70 transitional and mature B cells that acts as rheostat for the maturation of low-affinity autoreactive

71 fine-tune Nodal output, acting as a specific rheostat for the Nodal/TGFbeta pathway during the earlie

72 ress in differentiated tissues requires this rheostat for tissue resilience and continued function ov

73 us genetic programs and serve as pleiotropic rheostats for diverse physiological processes.

74 Hippo kinases Mst1 and Mst2 act as molecular rheostats for the terminal maturation and effector diffe

75 Srcasm may act as a molecular "rheostat" for activated SFKs, and cellular levels of Src

76 Variable phosphorylation thus serves as a "rheostat" for cell signaling to fine-tune transcription

77 0, whose inducible expression provides for a rheostat function by which other inflammatory stimuli ca

78 gs and their different potentials to serve a rheostat function for integrating fluctuating hormone le

79 tational impacts: Neutral (weak/no effects), Rheostat (function-tuning positions), or Toggle (on/off

80 as PD-1 and LAG-3 seem to serve more subtle rheostat functions.

81 ylation equilibrium functions as a molecular rheostat governing cellular transcription that is amenab

82 than H2(b) mice, providing evidence that the rheostat hypothesis regarding Ly49 affinities for MHC an

83 gether, we propose that HAPSTR1 is a central rheostat in a network of pathways responsible for cellul

84 ments suggest that AhR serves as a molecular rheostat in B cells to brake the effector response, poss

85 Together, these findings uncover p63 as a rheostat in coordinating the transition between squamous

86 ole for the ceramide/sphingosine-1-phosphate rheostat in maintaining lung cell survival, vascular bar

87 Cav1 acts as a cholesterol rheostat in MVBs, determining sorting of ECM components

88 point to an essential role for the O-GlcNAc rheostat in regulating cell division.

89 ponses, demonstrating platelets to be immune rheostats in both health and disease.

90 ciated role for decoy receptors as molecular rheostats in controlling the timing and extent of GPCR-m

91 glycolysis and oxidative phosphorylation are rheostats in immune cells whose bioenergetics have funct

92 monstrate that mTORC1 acts as a fundamental 'rheostat' in T(reg) cells to link immunological signals

93 size the existence of a glomerular perfusion rheostat, in which the shorter path periodically fluctua

94 opose that downhill folders may be molecular rheostats, in which effects could be modulated by alteri

95 This report demonstrates that this rheostat is an evolutionarily conserved stress-regulator

96 The ceramide-sphingosine 1-phosphate (S1P) rheostat is important in regulating cell fate.

97 at NK cell responsiveness is comparable to a rheostat: it is tuned to an optimal set point depending

98 cule, TGFbeta1-induced-1, which is a TGFbeta-rheostat known to have antagonistic effects on the endot

99 linker whose conformational state exercises rheostat-like control over the kinase activity.

100 Mechanistically, Zeb1 acts in a rheostat-like fashion to modulate murine and human osteo

101 adenylyl cyclase-cAMP-PKA axis in an immune rheostat-like fashion.

102 titution at position 311 (T311M) suggested a rheostat-like function.

103 Pin1's effect, however, suggests a rheostat-like influence on Rta function.

104 DNA-binding protein MECP2 and functions in a rheostat-like manner to fine-tune the cell-type-specific

105 tory interactions that can be unmasked, in a rheostat-like manner, by coincident regulatory factors t

106 tatively controlling promoter occupancy in a rheostat-like manner.

107 ariation in leaf shape can be created with a rheostat-like mechanism that alters the KNOX1 protein in

108 hat the level of FLC activity acts through a rheostat-like mechanism to control flowering time in Ara

109 e and stress granule assembly, and suggest a rheostat-like mechanistic paradigm for regulating live-o

110 Here we describe a new rheostat-like mechanistic relationship between PKM2 acti

111 ostat' constituent gene pairs, which exhibit rheostat-like mode-of-cooperation capable of fine-tuning

112 at acetylation and deacetylation provide the rheostat-like regulation for the cytokine receptor PRLR

113 different partners and generate a graded or rheostat-like response to phosphorylation.

114 on during zebrafish embryogenesis, revealing rheostat-like responses of an ERK-dependent morphogeneti

115 collectively regulate immune output through rheostat-like tuning of phytohormone levels.

116 ed the transcriptional cofactor TBL1XR1 as a rheostat linking inflammation to Wnt/beta-catenin signal

117 dPDZ-GEF-dependent signaling functions as a rheostat linking Rap activity to the regulation of cell

118 cytoplasmic process regulated by the energy rheostats mammalian target of rapamycin and AMP kinase (

119 ell types, and resetting of the ceramide/SPP rheostat may account for the pro-apoptotic effects of DM

120 to metabolic challenges, yet this metabolic rheostat may be downregulated under conditions of signif

121 evels of ceramide and S1P (the "ceramide/S1P rheostat") may determine cell survival, we investigated

122 (MCU) is crucial for melanogenesis while MCU rheostat, MCUb negatively control melanogenesis.

123 A graded rheostat mechanism obtained when either transactivators

124 These results are explained by a rheostat mechanism whereby CD45 differentially regulates

125 rization in asthmatic patients and propose a rheostat model of barrier dysfunction that implicates th

126 This study supports a rheostat model of Merlin in NHERF1 binding and contribut

127 The rheostat model suggests that both genetic and epigenetic

128 changes in PCL have no consequence; (ii) the rheostat model, in which a longer cilium enhances signal

129 of MITF are reversible, as expected from the rheostat model.

130 e results are consistent with the "molecular rheostat" model for RRE function, which suggests that Re

131 EpoNADA and epoNA5HT are dual-functional rheostat modulators of the endocannabinoid-TRPV1 axis.

132 main potassium channel, KCNK3, as a built-in rheostat negatively regulating thermogenesis.

133 than rheostat non-neutrals, while toggle and rheostat neutrals were incorrectly predicted to be diffe

134 ever, toggle non-neutrals were distinct from rheostat neutrals.

135 correctly predicted as more non-neutral than rheostat non-neutrals, while toggle and rheostat neutral

136 These findings highlight AHNAK as a rheostat of 53BP1 function, which surveys cell prolifera

137 we discovered that TBX1 acts as an intrinsic rheostat of BMP signalling: it is a gatekeeper that gove

138 e c-FLIP is a good candidate for a molecular rheostat of caspase-8 activity.

139 cotransporters, and functions as a molecular rheostat of cell volume in the mammalian brain.

140 cific phosphatase cofactor activity can be a rheostat of cellular homeostasis that initiates a functi

141 propose that SIRT1 functions as an enzymatic rheostat of circadian function, transducing signals orig

142 d functional genomics approach to identify a rheostat of DNA and RNA sensing-the inflammasome compone

143 lly, we identify SOX9 as a crucial chromatin rheostat of hair follicle stem cell super-enhancers, and

144 egulating the goblet cell UPR by acting as a rheostat of IRE1beta endonuclease activity.

145 Our results establish ATF4 as a cellular rheostat of MYC activity, which ensures that enhanced tr

146 ts demonstrate that mTOR acts as a molecular rheostat of NK cell reactivity controlled by educating r

147 cancer progression by serving as the common rheostat of Stat-3 and Wnt-signaling activation.

148 tions and membrane topology, is an important rheostat of T-cell signaling.

149 Our data define Nod2 as a T cell-intrinsic rheostat of Th17 immunity, and open new avenues for T ce

150 GRP78 is the rheostat of the ER stress transducers.

151 Our findings identify FOXO1 as a critical rheostat of vascular expansion and define the FOXO1-MYC

152 organization during inflammation, serving as rheostats of innate versus adaptive functions of the LN.

153 our findings expose NFIB and NFIX as crucial rheostats of tissue homeostasis, functioning to safeguar

154 ession genome-wide by acting as a 'molecular rheostat' of target genes.

155 hether the protein sequence position class - rheostat or toggle - affects these predictions.

156 Here we describe an epigenetic rheostat orchestrated by c-MYC and histone deacetylases

157 Here, we identify a transcriptional rheostat orchestrated by RELA that confers human T cells

158 ue cell competition, governed by a Snail/Yap rheostat, orchestrates lung architecture and provides a

159 Thus, substitutions at rheostat position 267 had wide-ranging effects on the ph

160 Here, we report a strong rheostat position in the integral membrane protein, Na(+

161 (5) In structural studies, substitutions at rheostat positions appear to cause only local perturbati

162 (2) Substitutions at rheostat positions can have biological consequences and

163 (4) Some rheostat positions have pleiotropic effects on function,

164 Previously, we evaluated rheostat positions located near the allosteric binding s

165 Overall, rheostat positions provide unique opportunities for usin

166 utions at toggle positions are binary, while rheostat positions show progressive changes.

167 ions in other proteins might be locations of rheostat positions.

168 nctional outcomes observed when substituting rheostat positions.

169 to understand the impact and significance of rheostat positions: (1) They have been observed in globu

170 fail for substitutions at the less-studied "rheostat" positions, which are defined when different am

171 e of functional outcomes upon substitution: "rheostat" positions.

172 ies identify activin E-ACVR1C as a metabolic rheostat promoting liver-adipose cross talk to restrain

173 The data indicate that p120 acts as a rheostat, promoting a sessile cellular phenotype when as

174 This metabolic rheostat protects obligate intracellular parasite stages

175 For example, a neuronal rheostat provides excitatory or inhibitory signals that

176 it to serve as a phosphorylation-controlled rheostat, providing a new paradigm for regulating the af

177 Thus, PDGFRalpha signaling acts like a rheostat rather than generic ON switch, with signal stre

178 ion, suggesting that BACH1 may function as a rheostat regulating levels of intracellular free heme.

179 degradation in macrophages, functioning as a rheostat regulating signaling (Freedman et al., 2015).

180 ll-intrinsic Arg1 functions as an unexpected rheostat regulating the kinetics of the mammalian Th1 li

181 refore, S1P can function as an extracellular rheostat regulating tonic and acutely evoked functions.

182 Thus, NK cells can act as rheostats, regulating CD4 T-cell-mediated support for th

183 Here we demonstrate that a liver immune rheostat renders virus-specific CD8 T cells refractory t

184 o play a cell-autonomous role as a migratory rheostat restricting migration of D6-expressing cells su

185 We propose a rheostat role for HIF-2alpha that allows for the mainten

186 thway is an organ growth and size regulation rheostat safeguarding multiple tissue stem cell compartm

187 Our data reveal LSD1 as a molecular rheostat selectively regulating H3K9 demethylation at ce

188 Thus, BTL2 serves as a surveillance rheostat sensing the perturbation of BAK1/SERK4 immune c

189 ond to build high-performance conformational rheostat sensors.

190 We propose that NIP45 acts as a molecular rheostat serving to amplify the type-2 immune response.

191 We conclude that Six1 homeoproteins act as a rheostat system to ensure proper regeneration of the tis

192 tokines condition thymic microenvironment to rheostat T cell selection and fine-tune central toleranc

193 es a previously unrecognized, crucial tissue rheostat that amplifies organ damage in autoimmune hosts

194 lation of GR by PI3K and PTEN functions as a rheostat that can be exploited for the treatment of PTEN

195 ular responses, with MiaA acting much like a rheostat that can be used to realign global protein expr

196 The role of CD39 as a rheostat that can have an impact on purinergic signallin

197 ta herein indicate that HIV-1 uses CD81 as a rheostat that controls different stages of the infection

198 mocytes during selection constitutes a novel rheostat that controls the maintenance of IL-7-expressin

199 nce cognition by interfering with the rhythm rheostat that controls the sleep/wake cycle.

200 represent an important facet of the cellular rheostat that determines survival and death decisions.

201 on is an important component of the cellular rheostat that determines susceptibility to DNA-damaging

202 ive cellular level has been proposed to be a rheostat that determines the fate of cells.

203 a model in which UPF3A serves as a molecular rheostat that directs developmental events.

204 factor EB (TFEB) as a central BCR-controlled rheostat that drives activation-induced apoptosis, and c

205 el reveals that cytoplasmic Ca(2+) acts as a rheostat that fine-tunes autophagic and apoptotic respon

206 ndings provide new insights into a molecular rheostat that fine-tunes Ca(2+)-entry and supports norma

207 sly unrecognized role for NIK as a molecular rheostat that fine-tunes immunometabolism in innate immu

208 ther, the immune system critically acts as a rheostat that fine-tunes the balance between dormancy an

209 hanges in microbial metabolites operate as a rheostat that governs protective versus pathologic ILC2

210 kinase signaling acts as a myelin thickness rheostat that instructs oligodendrocytes to generate axo

211 f rapamycin (mTOR) kinase acts as a cellular rheostat that integrates signals from a variety of cellu

212 stress and suggests that Hcm1 functions as a rheostat that integrates stimulatory and inhibitory sign

213 tudies show redox balance acts as a cellular rheostat that is central and causative for metabolic con

214 Fic-mediated AMPylation acts as a molecular rheostat that is required to temper the UPR response in

215 h an energy source and a protein-translation rheostat that is responsive to WNT and suggest that mani

216 FoxO may act as a rheostat that maintains homeostatic balance between Akt

217 d reveal PKM2 O-GlcNAcylation as a metabolic rheostat that mediates exquisite control of aerobic glyc

218 AC progression by functioning as a molecular rheostat that modulates cell-ECM interactions to reduce

219 s indicate that TAZ functions as a molecular rheostat that modulates MSC differentiation.

220 r phosphorylation functions as a biochemical rheostat that modulates mTORC1 signaling in accordance w

221 Specifically, OstR functions as a rheostat that optimizes emrB expression under oxidizing

222 These findings elucidate a translational rheostat that optimizes photosynthesis in response to sh

223 -Related Factor 2 (NRF2) is a critical redox rheostat that regulates oxidative stress responses, and

224 our findings identify p130Cas as a molecular rheostat that regulates the delicate balance between can

225 sly unknown role as a temperature-responsive rheostat that regulates UCP1-dependent thermogenesis.

226 Our results implicate SET-4 as a sensory rheostat that reinforces developmental fates in response

227 itochondrial membrane dynamics is a cellular rheostat that relates metabolic function and organelle m

228 hus, endogenous Gal1 serves as a homeostatic rheostat that safeguards immune tolerance and prevents a

229 rocal lipid exchange modes and function as a rheostat that sets the junctional PtdSer/PI(4)P ratio.

230 BATF as the key target of REGNASE-1 and as a rheostat that shapes antitumour responses.

231 R. mTORC1 as a cell-intrinsic rheostat that shapes development, preimmune repertoire,

232 ur findings indicate that mTORC1 serves as a rheostat that shapes differentiation along the B lineage

233 hus, acetyl-CoA functions as a carbon-source rheostat that signals the initiation of the cellular gro

234 These results reveal an endogenous immune rheostat that sits upstream of and governs sensory neuro

235 therefore built around a ubiquitin-dependent rheostat that tunes mitochondrial activity to redox need

236 Our work identifies RHBDL4 as a rheostat that tunes secretion dynamics and abundance of

237 a where it has been described as a molecular rheostat that, depending on activity levels, allows reve

238 propose that nociceptors have the role of a rheostat that, in a context-dependent manner, favors tis

239 cascades of modifications serve as molecular rheostats that fine-tune the control of transcription in

240 have identified a novel function for them as rheostats that modulate the strength of antigen receptor

241 We thus elucidate novel epigenetic rheostats that promote ionizing radiation hypersensitivi

242 roteins, which we identify as key mechanical rheostats that sequester YAP/TAZ in the cytoplasm.

243 ity, suggesting that it acts as a "molecular rheostat" that finely calibrates PRC2 functions at devel

244 toprotective pathway, as well as a metabolic rheostat, that affects cell maintenance and differentiat

245 AP/TAZ acting as an intracellular mechanical rheostat--that stores information from past physical env

246 oxidoreductases is thought to act as a redox rheostat, the sequence of which determines its reduction

247 According to the proposed rheostat theory, SPHK activity shifts the intracellular

248 monstrate that RECK controls this angiogenic rheostat through a novel complex with cell surface recep

249 act dynamic properties required in molecular rheostats, thus supporting a biological role for one-sta

250 d that the CP1 domain evolved as a molecular rheostat to balance multiple functions.

251 1(+) MSCs integrate hedgehog signalling as a rheostat to control BMP activation in the progenitor nic

252 gs indicate that PR functions as a molecular rheostat to control ERalpha chromatin binding and transc

253 ong-distance trafficking of SlCyp1 acts as a rheostat to control the shoot-to-root ratio, by mediatin

254 ts suggest that Rab3GAPL acts as a molecular rheostat to coordinate autophagic flux and defense-relat

255 plasticity via an individual cell-intrinsic rheostat to enable T cell subset adaptation to subsequen

256 Multisite phosphorylation thus acts as a rheostat to enhance binding to CBP/p300 and provides a p

257 cting partner that acts as a transcriptional rheostat to fine tune the expression of the fab genes ba

258 dynamic acetylation/deacetylation acts as a rheostat to fine-tune Aurora B activity during mitotic p

259 These enzymes act as a rheostat to fine-tune protein function in response to a

260 processes, with glycolytic ATP serving as a rheostat to gauge PI3K-Akt-Foxo1 signaling in the contro

261 RAS/ERK signaling thus acts as a rheostat to influence neural cell fate selection in both

262 This SCA network acts as a signalling rheostat to integrate signals between dimer partners, li

263 rated for the first time that SGK1 acts as a rheostat to limit P. gingivalis-induced inflammatory imm

264 rsatile regulator of enhancers and acts as a rheostat to maintain optimal enhancer activity by counte

265 where cell-membrane potential functions as a rheostat to modulate the SOCE response.

266 igomerization potential serve as a molecular rheostat to precisely co-ordinate B. subtilis cell size

267 Mechanistically, USP7 acts as a molecular rheostat to precisely fine-tune endosomal F-actin levels

268 iquitin ligase UBR5 functions as a molecular rheostat to prevent excess accumulation of MYC protein.

269 ntify an RHBDL4-mediated axis that acts as a rheostat to prevent over-activation of the TLR4 pathway.

270 of Trbl to the fat body cell membrane acts a rheostat to reduce the strength of Akt-mediated insulin

271 eam networks that serve as a transcriptional rheostat to regulate Etv2 gene expression.

272 hus, acetylation of chromatin functions as a rheostat to regulate pH(i) with important implications f

273 binary switch, but rather acts as a tunable rheostat to regulate replication initiation events.

274 Bub1 and Sgo1 act as a rheostat to regulate the chromatin spring and maintain f

275 20(ctn) may accomplish this is to serve as a rheostat to regulate the levels of cadherin.

276 AMPylated BiP acts as a molecular rheostat to regulate UPR signaling, yet little is known

277 5-HT2CR functional status acting as a neural rheostat to regulate, in part, the intersection between

278 ivation of the calcineurin pathway acts as a rheostat to shape both the phenotype and effector potent

279 nicated into the mitochondrion and acts as a rheostat to support GDH activity and cell viability.

280 differential phosphorylation, SMO acts as a rheostat to translate graded HH signals into distinct re

281 ction and sepsis, where they act as critical rheostats to amplify innate immunity and regulate tissue

282 microRNAs (miRNAs) function as genetic rheostats to control gene output.

283 gration, and feedback loops act as molecular rheostats to fine-tune gene expression levels and physic

284 ctive lipid metabolites serving as metabolic rheostats to integrate environmental cues and interplay

285 that for most interactions microRNAs act as rheostats to make fine-scale adjustments to protein outp

286 of thrombin and that AR2 may be a "molecular rheostat" to promote thrombin inhibition in the presence

287 Disturbed migratory rheostat tone could account for variations in interindiv

288 ility of natural killer (NK) cells to act as rheostats tuning outcomes, and the role of the innate im

289 suggests that ULK1/2 function as biological rheostats, tuning cellular functions to intra and extra-

290 The circuit, a Tunable Noise Rheostat (TuNR), consists of a transcriptional cascade o

291 ed feedback from adaptive immunity engages a rheostat, TYRO3, on innate immune cells to limit the int

292 we investigated the role of the sphingosine rheostat, which has diverse inflammatory effects.

293 dings implicate Cxcr4 as a female adipogenic rheostat, which may inform strategies to target female a

294 hat over and underscale with size can act as rheostats, which regulate cell cycle progression.

295 predictable background via a transcriptional rheostat whose moment-to-moment state reflects the past

296 We show that the RNA thermometer acts as a rheostat, whose stability is optimized to respond in a s

297 utamylation and glycylation are antagonistic rheostats with glycylation protecting microtubules from

298 er, the results support a role for CD45 as a rheostat, with both positive and negative regulatory fun

299 CDK5 thus acts as a molecular rheostat, with different activity levels eliciting disti

300 point to a mechanism in which lncRNAs act as rheostats within lncRNA-TF gene duplex loci that buffer