ライフサイエンスコーパス: ribitol

1 glucuronic acid, any-N-acetylated sugar, or ribitol).

2 lpNAc-(1-->5)-Rbo-1-P-->, respectively (Rbo, ribitol).

3 bitol, whereas SLC35A4 might only accept CDP-ribitol.

4 Both serotypes have a beta-d-Galp branch to Ribitol.

5 acetamido-2-deoxy-beta-glucopyranosyl)-1-->4-ribitol-1-OPO3-->.

6 terin-6-ylmethyl-l-(4-aminophenyl)-1-deoxy-D-ribitol 5'-phosphate (4') in a reaction stimulated by th

7 terin-6-ylmethyl-1-(4-aminophenyl)-1-deoxy-D-ribitol (5').

8 ose (1-->3) glucose (1-->3) rhamnose (1-->3) ribitol (5-->phosphate.

9 1 (1-->3) glucose 2 (1-->3) rhamnose (1-->3) ribitol (5-->phosphate.

10 indings identify linkages from alpha-Galp to ribitol-5-phosphate and from this residue to adjacent Ga

11 accharide capsule is a polymer of ribose and ribitol-5-phosphate and is a critical determinant of vir

12 lpha1-2 transfer of Gal pyranoside (Galp) to ribitol-5-phosphate in the synthesis of CPS10A, CPS47F,

13 d CPS34 but with alpha1-1 transfer of Gal to ribitol-5-phosphate in the synthesis of CPS39.

14 FKRP functions as ribitol-5-phosphate transferase with CDP-ribitol as the

15 It has been proposed that FKRP, a ribitol-5-phosphate transferase, is a participant in alp

16 levels of CDP-ribitol, the substrate for the ribitol-5-phosphate transferases FKRP and FKTN.

17 ical, except for the linkage between Gal and ribitol-5-phosphate, which is alpha1-2 in strain SK144 v

18 s identify genetic markers for the different ribitol-5-phosphate-containing types of RPS present in S

19 associated with alpha1-1 transfer of Galp to ribitol-5-phosphate.

20 -dependent alpha1-4 linkages between Gal and ribitol-5-phosphate.

21 -5-[1-alpha -D- ribofuranosyl 5-phosphate]-D-ribitol (9').

22 iminosugars including 1,5-dideoxy-1,5-imino-ribitol and 1,5-dideoxy-1,5-imino-DL-arabinitol, startin

23 f other bacterial polysaccharides containing ribitol and glycerol phosphates, including H. influenzae

24 One group was negative for I-erythritol and ribitol and included all the isolates belonging to Nocar

25 ir similarity in enhancing the levels of CDP-ribitol and matriglycan synthesis.

26 ng: whereas the isoalloxazine ring linked to ribitol and one phosphate is sufficient to drive complet

27 Clinical trials with both ribitol and ribose have been reported for treating LGMD2

28 Supplement of ribitol and ribose have been reported to increase the le

29 D-glucitol, i-myo-inositol, D-mannitol, and ribitol and susceptibility to amoxicillin-clavulanic aci

30 ee groups were positive for I-erythritol and ribitol and were grouped within Nocardia transvalensis.

31 d urinary excretion of erythritol, arabitol, ribitol, and pent(ul)ose-5-phosphates was detected, as w

32 a polyhydroxy alkane, including glycerol and ribitol, and phosphoric acid, joined to form phosphodies

33 butyric acid (DHBA), 3,4-DHBA, ribonic acid, ribitol, and the triglycerides 50:1 and 50:2 significant

34 precursor to the 1-(4-aminophenyl)-1-deoxy-D-ribitol (APDR) moiety present in the C(1) carrier coenzy

35 col (SG or UG) in residues such as glycerol, ribitol, arabinitol, furanosyl galactose, and sialic aci

36 s [(1S)-substituted 1, 4-dideoxy-1,4-imino-D-ribitols] are powerful inhibitors for the nonspecific nu

37 as ribitol-5-phosphate transferase with CDP-ribitol as the substrate for the extension of the glycan

38 (9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol at the depurination site binds four times better

39 r RNA stem-loop with 1,4-dideoxy-1,4-imino-D-ribitol at the depurination site binds with a K(d) of 1.

40 very of WWS myotubes is promoted not only by ribitol but also by its precursor ribose.

41 Supplement of ribitol changes lysophospholipid sub-pathway metabolite

42 Disparity in GlcNAc to ribitol connectivity, as well as variable O-acetylation

43 We recently demonstrated that ribitol, considered to be a metabolic end-product, enhan

44 current study, we tested the hypothesis that ribitol could also enhance matriglycan expression in can

45 nt pyridine nucleotide reductase and glucose/ribitol dehydrogenase families, respectively.

46 The ribitol effect is associated with an increase in levels

47 ylose, mannose, maltose, gluconolactone, and ribitol) exclusively used by soil commensal bacteria (no

48 o 7,8-didemethyl-8-hydroxy-5-deazariboflavin ribitol (Fo).

49 , ribose, lyxose, lyxitol (0.5 mo); mannose, ribitol, glycerol, isothreonic acid, lyxitol (2 mo); lyx

50 9-deazaguanin-9-yl)-1,4-dideoxy-1, 4-imino-D-ribitol (immucillin-G).

51 azahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol (immucillin-H) and (1S)-1-(9-deazaguanin-9-yl)-1

52 educed sugar nucleotide for the insertion of ribitol in a phosphodiester linkage to the glycoprotein.

53 Thus, we propose a novel structure-a ribitol in a phosphodiester linkage-for the moiety on wh

54 been reported to increase the levels of CDP-ribitol in both cells and in muscles in vivo.

55 ngs provide the rationale for testing ribose/ribitol in combination with NAD+ to treat WWS and other

56 levated amounts of erythritol, arabitol, and ribitol in the plasma of affected individuals.

57 The fact that ribitol is a metabolite in nature and has already been t

58 Our results showed for the first time that ribitol is able to significantly enhance the expression

59 Direct use of CDP-ribitol is also effective for matriglycan expression.

60 Since CDP-ribitol is synthesized in the cytoplasm, we hypothesized

61 azahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol] is a 23 pM inhibitor of bovine purine nucleosid

62 cells, FGGY can additionally participate in ribitol metabolism.

63 or with a protonated 1,4-dideoxy-1,4-imino-D-ribitol moiety, a 4-azasugar mimic, at the depurination

64 good overall yields of 1,5-dideoxy-1,5-imino-ribitol of 54%, 1,5-dideoxy-1,5-imino-D-arabinitol of 48

65 onal modeling demonstrate that Galf(OAc)-1,1-Ribitol of the repeating unit of 35B CPS constitutes the

66 glycosyltransferase that in vivo transfers a ribitol phosphate group from a CDP -ribitol present in m

67 s the only mammalian glycan known to contain ribitol phosphate groups.

68 lgi apparatus use CDP-ribitol to incorporate ribitol phosphate into the glycan chain of a-dystroglyca

69 eaves WTA synthesis intermediates, releasing ribitol phosphate into the medium and recycling bactopre

70 d polymers containing repeating polyglycerol/ribitol phosphate moieties.

71 , catalyzes both the addition of the priming ribitol phosphate onto the linkage unit and the subseque

72 Complementation studies show that a putative ribitol phosphate polymerase, TarL, catalyzes both the a

73 Deltalcp mutant synthesized WTA yet released ribitol phosphate polymers into the extracellular medium

74 so a bifunctional enzyme that catalyzes both ribitol phosphate priming and polymerization.

75 Two major structures, 1,5-poly(ribitol phosphate) and 1,3-poly(glycerol phosphate), wit

76 ria toxin and the attachment of poly(ribosyl-ribitol phosphate) carbohydrate chains results in a stil

77 revised assembly pathway for the late-stage ribitol phosphate-utilizing enzymes is proposed.

78 ib capsular polysaccharide IgG, poly-ribosyl-ribitol-phosphate (PRP), IgG subclass, and cellular immu

79 , the form of IgA in response to polyribosyl-ribitol-phosphate (PRP), the capsular polysaccharide of

80 nd tetrasaccharides and a negatively charged ribitol-phosphate construct to BSA.

81 stor of BL21(DE3) may have produced a ribose/ribitol-phosphate containing polysaccharide.

82 cetylmuramic acid with wall teichoic acid, a ribitol-phosphate polymer tethered to murein linkage uni

83 ws: 24F has arabinitol-phosphate and 24B has ribitol-phosphate.

84 ion of proteins in cells but still supported ribitol phosphorylation.

85 Lipoteichoic acid (LTA), a cell wall ribitol polymer from Gram-positive organisms, mediates i

86 nsfers a ribitol phosphate group from a CDP -ribitol present in muscles to alpha-DG, while in vitro i

87 It is known that the putative ribitol primase, TarK, is also a bifunctional enzyme tha

88 Ribitol relies on residual FKRP function and restores li

89 or-sera 24d and 24e recognize arabinitol and ribitol, respectively, which explains the serology of se

90 ISPD is a CDP-ribitol (ribose) pyrophosphorylase that generates the re

91 ow dose (1e-13 vg/kg) AAV-FKRP combined with ribitol showed a 22.6% increase in positive matriglycan

92 This functional glycan contains a novel ribitol structure that links a phosphotrisaccharide to x

93 Ribitol teichoic acid (RTA) (1 microg/ml) induced a twof

94 ut not by dextran, dextran sulfate, heparin, ribitol teichoic acid, or soluble low molecular weight P

95 associated with an increase in levels of CDP-ribitol, the substrate for the ribitol-5-phosphate trans

96 F and 24B repeating units, with the ratio of ribitol to arabinitol being strain dependent.

97 Enzymes in the Golgi apparatus use CDP-ribitol to incorporate ribitol phosphate into the glycan

98 We discovered that CDP-ribitol transport relies on the CMP-sialic acid transpor

99 lite profiles of the skeletal muscle between ribitol-treated and ribose-treated FKRP mutant mice.

100 deno-associated virus (AAV) gene therapy and ribitol treatment demonstrating significant therapeutic

101 Ribitol treatment does not alter the expression of FKRP,

102 n with highest levels in S and G2 phases and ribitol treatment does not alter the pattern.

103 cells, ribulose could only be detected when ribitol was added to the cultivation medium, and under t

104 ich is capable of transferring arabinitol or ribitol when arabinitol is limiting.

105 ion of high-dose (5e-13 vg/kg) AAV-FKRP with ribitol, whereas low dose (1e-13 vg/kg) AAV-FKRP combine

106 he bulky CMP-sialic acid and the smaller CDP-ribitol, whereas SLC35A4 might only accept CDP-ribitol.

107 support the potential benefits of combining ribitol with AAV gene therapy for treating FKRP-related

108 After all, from studying such pentitols as ribitol with Professor Touster at Vanderbilt University

109 h of which starts with glucose and ends with ribitol, with the lipid anchor predicted to be Glc(beta1