ライフサイエンスコーパス: ribonucleoside

1 (60-75%) without any 4-substituted imidazole ribonucleoside.

2 s dipyridamole and nitrobenzylmercaptopurine ribonucleoside.

3 with 2'-deoxyribonucleosides, as compared to ribonucleosides.

4 action with the 2'-alpha-hydroxy moieties of ribonucleosides.

5 boxylic acid derivatives of all four natural ribonucleosides.

6 HCMV to four different 3-substituted indole ribonucleosides.

7 a series of heterobase-modified 2'-C-methyl ribonucleosides.

8 h Bu3SnH and then converted to carbocyclic C-ribonucleosides 1, 3, and 4.

9 uted, the 5,6-dimethyl, and the 5,6-difluoro ribonucleosides (19, 20, and 2, respectively), were inac

10 on from the corresponding 5'-O-DMTr-2'-O-TBS-ribonucleosides (1a-1d).

11 Ribonucleoside 2',3'-cyclic phosphates (N>p's) are gener

12 cient formation of stable and yet reversible ribonucleoside 2'-conjugates in yields of 69-82%.

13 avage at genomic ribonucleotides can produce ribonucleoside-2',3'-cyclic phosphate-terminated nicks.

14 emistry thus suggests a prebiotic route from ribonucleoside-2',3'-cyclic phosphates to predominantly

15 The recent synthesis of pyrimidine ribonucleoside-2',3'-cyclic phosphates under prebiotical

16 5,6-trichloro analog (TCRB), the 5,6-dibromo ribonucleoside 3 was active against HCMV (IC50 approxima

17 lid-phase synthesis using 5'-O-DMTr-2'-O-TBS-ribonucleoside 3'-N,N-dimethyl-S-(2,4-dichlorobenzyl) ph

18 The phosphomonoesterase converts a terminal ribonucleoside 3'-PO4 or deoxyribonucleoside 3'-PO4 of a

19 irst removed to yield a primer strand with a ribonucleoside 3'-PO4 terminus, and (ii) the 3'-PO4 is h

20 bonucleotide to yield a primer strand with a ribonucleoside 3'-PO4 terminus, requires the vicinal 2'-

21 bonucleotide to yield a primer strand with a ribonucleoside 3'-PO4 terminus.

22 he phosphomonoesterase converts the terminal ribonucleoside 3'-PO4 to a 3'-OH.

23 e have examined the effect of 3'-deoxy-2'-5'-ribonucleoside (3'-deoxynucleoside) incorporation into C

24 logy is based on 5'- O -(DMTr)-2'- O -(Fpmp)-ribonucleoside-3'- H -phosphonate building blocks 10.

25 nitiates reduction of the 2' position of the ribonucleoside 5'-diphosphate substrate by abstracting t

26 aerobic enzymes catalyzing the reduction of ribonucleoside 5'-diphosphates by a mechanism that requi

27 Ribonucleoside 5'-monophosphates (rNMPs) are the most co

28 vated MoNA monomers from their corresponding ribonucleoside 5'-monophosphates and the synthesis of an

29 structure of HCoV-OC43 N-NTD complexed with ribonucleoside 5'-monophosphates to identify a distinct

30 e derivative 5-amino-4-imidazole carboxamide ribonucleoside 5'-phosphate (ZMP), an intermediate in de

31 n of the DNA template by RNAP on addition of ribonucleoside 5'-triphosphates (NTPs) in sequential AFM

32 quencies in RNA and the balance of dNTPs and ribonucleoside 5'-triphosphates (rNTPs) in the cellular

33 as a steric gate to preclude the binding of ribonucleoside 5'-triphosphates, prevents the effective

34 We show here that ribonucleoside-5'-diphosphates (NDPs) can be utilized as

35 f any such pathway, involves the reaction of ribonucleoside-5'-phosphorimidazolides with an RNA prime

36 additional substrates including 6-oxopurine ribonucleosides, 6-aminopurine ribonucleosides, and to a

37 iodo-2'-deoxyuridine (5-IdU), as well as the ribonucleosides 8-bromoguanosine and 8-bromoadenosine.

38 We discovered five ribonucleosides-8-azaadenosine, formycin A, 3-deazauridi

39 5-Aminoimidazole-4-carboxamide ribonucleoside, a pharmacological AMPK activator that is

40 5'-Aminoimidazole-4-carboxamide ribonucleoside activation of the kinase AMPK is known to

41 cation in tumor cells by increasing cellular ribonucleoside activity.

42 unds were less active than the benzimidazole ribonucleosides against human cytomegalovirus (HCMV) and

43 of AMPK with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) also resulted in an approximate t

44 g of 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside (AICAR) and N-acetyl cysteine (NAC) to at

45 ting compound 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) ex vivo.

46 treated with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in vivo, and also in muscles incu

47 ated directly from aminoimidazolecarboxamide ribonucleoside (AICAR) or from inhibition of purine synt

48 e presence of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) or metformin, 2 known AMPK activa

49 reatment with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) prevents this heat-induced sudden

50 we show that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) reverses the sensitivity of Akt-e

51 s of 5-aminoimidazole-4-carboxamide 1-beta-d-ribonucleoside (AICAR) were used to activate AMPK in mal

52 e report that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), a 5'-AMP kinase activator, rapid

53 al muscle with 5-aminoimidazole-4carboxamide ribonucleoside (AICAR), a compound that activates 5'-AMP

54 muscles with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), a compound that results in incre

55 we show that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), a pharmacological activator of A

56 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr), a precursor in purine biosynthes

57 ells with 5-aminoimidazole-4-carboxamide 1-D-ribonucleoside (AICAR), a prototypical AMPK activator, c

58 nd C (CC) or 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR), an inhibitor and activator of AM

59 se activator, 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), in active and passive EAE induce

60 of cells with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), so as to simulate elevated AMP l

61 oth H2O2 and 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR)-induced downstream signaling.

62 sociated with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)-stimulated glucose transport medi

63 cose, 5-aminoimidazole-4-carboxamide-1beta-4-ribonucleoside (AICAR; an activator of AMP kinase), or g

64 heir iminoether functions to give the native ribonucleosides along with the innocuous nitrile side pr

65 An evolved fluorescent ribonucleoside alphabet comprising isomorphic purine ((t

66 in as well as 5-aminoimidazole-4-carboxamide ribonucleoside, an AMPK agonist, significantly increased

67 e, we report the antiviral mechanism for the ribonucleoside analog 5-azacytidine (5-AZC).

68 The ribonucleoside analog ribavirin (1-beta-D-ribofuranosyl-

69 Therefore, ribonucleoside analogs as inhibitors of viral RNA polyme

70 y described here, we investigated a panel of ribonucleoside analogs for their ability to affect HIV-1

71 ovide the first demonstration of a series of ribonucleoside analogs that can target HIV-1 reverse tra

72 were less cytotoxic than their corresponding ribonucleoside analogs.

73 ur phosphoramidate ProTide technology to the ribonucleoside analogue 4'-azidouridine to generate nove

74 This ribonucleoside analogue accumulates as a triphosphate an

75 or the synthesis of a fluorescent pyrimidine ribonucleoside analogue and its enzymatic incorporation

76 ted the development of an orally efficacious ribonucleoside analogue inhibitor of influenza viruses,

77 synthesis of 8-nitro-2'-O-methylguanosine, a ribonucleoside analogue of this lesion, which is suffici

78 Despite this, the ribonucleoside analogue, 8-chloro-adenosine (8-Cl-Ado),

79 otent antiviral activity of a broad-spectrum ribonucleoside analogue, beta-d-N (4)-hydroxycytidine (N

80 A new fluorescent ribonucleoside analogue, containing 5-aminoquinazoline-2

81 Novel purine ribonucleoside analogues (9-13) containing a 4-substitut

82 idate ProTides can deliver monophosphates of ribonucleoside analogues and suggest a potential path to

83 ied protein nanopore can be used to identify ribonucleoside and 2'-deoxyribonucleoside 5'-monophospha

84 scribe the synthesis of the furan-containing ribonucleoside and its triphosphate, as well as their ba

85 Vanadyl ribonucleoside and orthovanadate are commonly employed a

86 Facile syntheses of C-6 azidopurine ribonucleosides and 2'-deoxyribonucleosides have been de

87 ecific combinations of amino acids or purine ribonucleosides and amino acids are required for efficie

88 Among the functionalized ribonucleosides and anomeric 2'-deoxyribonucleosides, so

89 Protected guanosine and adenosine ribonucleosides and guanine nucleotides are readily func

90 sponding series of chlorinated benzimidazole ribonucleosides and the fact that 5'-deoxy analogues of

91 2'-C-methyl-4-amino-pyrrolo[2,3-d]pyrimidine ribonucleosides and their improved pharmacokinetic prope

92 ribose aminooxazoline to the pyrimidine beta-ribonucleosides and their phosphate derivatives that inv

93 from the four deoxyribonucleosides, the four ribonucleosides, and 5-methyl-2'-cytidine, a RNA methyla

94 lysis, reversed-phase HPLC resolution of the ribonucleosides, and identification and quantification o

95 to apply to D-ribose, D-ribose 1-phosphate, ribonucleosides, and ribonucleotides in general.

96 g 6-oxopurine ribonucleosides, 6-aminopurine ribonucleosides, and to a lesser extent purine arabinosi

97 , traditional methods for detecting modified ribonucleosides are labor- and time-intensive, they requ

98 The 2'-C-methyl ribonucleosides are nucleoside analogs representing an i

99 2'-O-Aminooxymethyl ribonucleosides are prepared from their 3',5'-disilylate

100 proach, the relative proportions of modified ribonucleosides are quantified in several micrograms of

101 ts discovery revealed a class of amino/imino ribonucleoside artifacts that are generated during RNA h

102 The Raman spectra of purine ribonucleoside as well as a stable model compound (1-met

103 cribe the synthesis of novel 5-haloimidazole ribonucleosides as precursors of modified cobalamins.

104 e base to yield 1-hydroxyl-1,6-dihydropurine ribonucleoside, as suggested earlier by X-ray crystallog

105 Introduction of a single ribonucleoside at the scissile phosphate of an otherwise

106 oward enantiomerically pure (S)-methanocarba ribonucleosides based on several functional group transf

107 80 7-(het)aryl- and 7-ethynyl-7-deazapurine ribonucleosides bearing a methoxy, methylsulfanyl, methy

108 /or that either or both have a benzimidazole ribonucleoside binding site.

109 h, only inhibitors of the de novo pyrimidine ribonucleoside biosynthesis mimicked observations seen i

110 ntification and quantification of individual ribonucleosides by LC-MS via dynamic multiple reaction m

111 eplication in macrophages is unique and that ribonucleoside chain terminators may be a new class of a

112 In addition, the 2'-O-methylated ribonucleosides (Cm and Am) are present at higher levels

113 to RNase A inhibitors, sensitive to vanadyl ribonucleoside complex, and dependent on magnesium.

114 ly inhibited by ethidium bromide and vanadyl ribonucleoside complexes.

115 substituted and N7, C8-disubstituted guanine ribonucleosides comprise a class of small molecules with

116 cing (NGS) platform: viral Photo-Activatable Ribonucleoside CrossLinking (vPAR-CL).

117 Using photoactivatable ribonucleoside crosslinking and an innovative biotinylat

118 biotic synthesis of the canonical pyrimidine ribonucleosides (cytidine and uridine), and we show that

119 ve cleavage of O2' and O3' ester groups from ribonucleoside derivatives has been accomplished with Do

120 ric series of new thieno-fused 7-deazapurine ribonucleosides (derived from 4-substituted thieno[2',3'

121 of its four activities, vaccinia virus-coded ribonucleoside diphosphate (rNDP) reductase shows respon

122 alytically essential free radical of class I ribonucleoside diphosphate (rNDP) reductase, thereby blo

123 in an as yet undefined stoichiometry to form ribonucleoside diphosphate reductase (ribonucleotide red

124 nrdE, and nrdF, which encode the subunits of ribonucleoside diphosphate reductase and which are not p

125 rotein to the enzymatic mechanism of aerobic ribonucleoside diphosphate reductase from Escherichia co

126 The smallest known intein, found in the ribonucleoside diphosphate reductase gene of Methanobact

127 e find specific alleles of bunched (bun) and Ribonucleoside diphosphate reductase large subunit (RnrL

128 teraction of the adenosylcobalamin-dependent ribonucleoside diphosphate reductase of Corynebacterium

129 te the apparent equilibrium constants of the ribonucleoside diphosphate reductase reaction and the ri

130 Inactivation of ribonucleoside diphosphate reductase with 2'-azido-2'-de

131 Prereduced R1 dimer of ribonucleoside diphosphate reductase, in the presence of

132 ses a diferric-tyrosyl radical essential for ribonucleoside diphosphate reduction.

133 uman FMN cyclase, which splits FAD and other ribonucleoside diphosphate-X compounds to ribonucleoside

134 nes encoding the large and small subunits of ribonucleoside-diphosphate reductase) originated before

135 otein FtsZ, chaperonins GroES and GroEL, and ribonucleoside-diphosphate reductase.

136 the enzyme that catalyzes the conversion of ribonucleoside diphosphates (NDP) to deoxyribonucleoside

137 ole in RNA degradation, generating a pool of ribonucleoside diphosphates (rNDPs) that can be converte

138 quantitation of nanomolar concentrations of ribonucleoside diphosphates (rNDPs).

139 inding of effectors indicate that binding of ribonucleoside diphosphates at the catalytic site influe

140 esponsible for the de novo conversion of the ribonucleoside diphosphates to deoxyribonucleoside dipho

141 f the 5'-O-tosylates for both the deoxy- and ribonucleosides enabled preparation of the diphosphate e

142 We used photoactivatable ribonucleoside-enhanced cross-linking and immunoprecipit

143 Using photoactivatable ribonucleoside-enhanced cross-linking and immunoprecipit

144 ma cells through integrated Photoactivatable-Ribonucleoside-Enhanced Cross-Linking and Immunoprecipit

145 -seq and AGO2 PAR-CLIP-seq (photoactivatable-ribonucleoside-enhanced cross-linking and immunoprecipit

146 d WIG1-binding motifs using photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipita

147 Using photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipita

148 Combining photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipita

149 at interact with eIF3 using photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipita

150 Photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipita

151 on of AMPK by 5-aminoimidazole-4-carboxamide ribonucleoside exacerbated damage.

152 on of AMPK by 5-aminoimidazole-4-carboxamide ribonucleoside facilitates tight junction assembly under

153 e syntheses of a group of 4'-thiaspirocyclic ribonucleosides featuring both pyrimidine and purine cla

154 acetals, provides reversible 2'-O-protected ribonucleosides for potential applications in the solid-

155 nclude that the strong preference of guanine ribonucleosides for the anti conformation is the driving

156 amidate prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides form a novel class of HCV NS5B RNA-depen

157 (Q) and archaeosine (G(+)) are hypermodified ribonucleosides found in tRNA.

158 model compound (1-methoxyl-1,6-dihydropurine ribonucleoside), free in solution and bound into its com

159 of 5'-modified 2,5,6-trichlorobenzimidazole ribonucleosides has been synthesized and tested for acti

160 imidine (methylpyrazolo-fused 7-deazapurine) ribonucleosides have been designed and synthesized.

161 As compared with previous reports on ribonucleosides, higher levels of triphosphate were form

162 Introduction of a single ribonucleoside immediately 5' of the scissile phosphate

163 s of the biologically important 6-arylpurine ribonucleoside in a single step from unactivated and unp

164 2,6-Diaminopurine ribonucleoside in RNA is not a substrate for ADAR, in co

165 haracterization of a non-natural mcm(5) isoC ribonucleoside in S. cerevisiae total tRNA hydrolysate b

166 tem-level analysis of the dozens of modified ribonucleosides in ncRNA, characterization of novel long

167 tility and uniqueness of 2'-O-aminooxymethyl ribonucleosides in the preparation of modified RNA seque

168 Among the >120 modified ribonucleosides in the prokaryotic epitranscriptome, man

169 tation by uniquely reprogramming 40 modified ribonucleosides in tRNA, which correlate with selective

170 ue for the quantitative analysis of modified ribonucleosides in tRNA.

171 a stress-specific reprogramming of modified ribonucleosides in tRNA.

172 A and -RNA target strands suggest that 2'-5'-ribonucleoside incorporation into 3'-5'-oligodeoxyribonu

173 Ribonucleosides inhibit human immunodeficiency virus typ

174 alpha, beta, and gamma) and 2'-beta-C-methyl ribonucleoside inhibitors.

175 The most commonly used fluorescent ribonucleoside is 2-aminopurine, a highly responsive pur

176 4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine ribonucleoside, is orally bioavailable in the rat.

177 NA sequences capable of cleaving an internal ribonucleoside linkage.

178 t purine deoxyribonucleosides and pyrimidine ribonucleosides may have coexisted before the emergence

179 Thus, mutagenic ribonucleosides may represent an important class of anti

180 tional mechanistic insights into 2'-C-methyl ribonucleoside-mediated RNA chain termination.

181 assay and 2-amino-6-mercapto-7-methylpurine ribonucleoside (MESG) as substrate and a robot-based enz

182 iF-rU/C represents rare examples of "locked" ribonucleoside mimics that lack a bicyclic ring structur

183 quencing method that exploits the paucity of ribonucleoside modifications at the 3'-end of tRNAs to q

184 nalysis revealing seven post-transcriptional ribonucleoside modifications in the 5S rRNA.

185 f novel RNA species and post-transcriptional ribonucleoside modifications, and an emerging appreciati

186 These compounds are ribonucleoside mono- and disulfates derived from guanosi

187 er ribonucleoside diphosphate-X compounds to ribonucleoside monophosphate and cyclic X-phosphodiester

188 a nick generated by DNA topoisomerase I at a ribonucleoside monophosphate residue.

189 nfluencing the frequency of incorporation of ribonucleoside monophosphates (rNMPs) by DNA polymerases

190 transcriptase (RT) efficiently incorporates ribonucleoside monophosphates (rNMPs) during DNA synthes

191 cing techniques have made it possible to tag ribonucleoside monophosphates (rNMPs) embedded in genomi

192 Ribonucleotide excision repair (RER) removes ribonucleoside monophosphates (rNMPs) from genomic DNA,

193 Despite the abundance of ribonucleoside monophosphates (rNMPs) in DNA, sites of r

194 DNA polymerases incorporate ribonucleoside monophosphates (rNMPs) into genomic DNA a

195 Ribonucleoside monophosphates (rNMPs) mis-incorporated d

196 pecialized to remove single ribonucleotides [ribonucleoside monophosphates (rNMPs)] from duplex DNA,

197 n of mutations arising from mis-insertion of ribonucleoside monophosphates during DNA replication.

198 ssing-gap filling that mediates tolerance of ribonucleoside monophosphates in the genome.

199 tion of SLC29A1 by nitrobenzylmercaptopurine ribonucleoside (NBMPR) caused a 33% to 45% reduction of

200 hatase (AphA), and the produced nicotinamide ribonucleoside (NmR) enters the cell via the PnuC transp

201 stion mark2,3-dimidazoles and the N1- and N3-ribonucleosides of 2-substituted 6,7-dichloroimidazo inv

202 The effects of methylated ribonucleosides on translation could be attributed to th

203 in the tissue preparation containing vanadyl ribonucleoside or orthovanadate.

204 on of AMPK by 5-aminoimidazole-4-carboxamide ribonucleoside or transfection with an adenovirus encodi

205 sidues in the N-conformation as observed for ribonucleosides or 2'-deoxy-2'-fluororibonucleosides.

206 K) activator 5'-aminoimidazole-4-carboxamide ribonucleoside partially reversed the inhibition of insu

207 Conversion of the thiosugar into the four ribonucleoside phosphoramidite building blocks was accom

208 xymethyl group for 2'-hydroxyl protection of ribonucleoside phosphoramidites 9a-d has been implemente

209 otides and have motivated the development of ribonucleoside phosphoramidites that would exhibit coupl

210 4(5)-haloimidazoles produces 5-haloimidazole ribonucleosides predominantly in the alpha-configuration

211 nd prevented 5-aminoimidazole-4-carboxyamide ribonucleoside-reduced STAT1 phosphorylation.

212 hod involves protection of the 2-aminopurine ribonucleoside, reduction to the deoxyribonucleoside and

213 t for 3'-phosphatase activity but not for 3' ribonucleoside removal (Arg-14, Asp-15, Glu-21, Gln-40,

214 tical for 3'-phosphatase activity but not 3'-ribonucleoside removal; and (iii) at Lys66 and Arg76, wh

215 Here we characterize the 3'-ribonucleoside-resecting activity of Candidatus Korarcha

216 nucleotides containing 2'-O-(2-methoxyethyl) ribonucleoside residues and phosphorothioate and phospho

217 e efficiently than wild type on a variety of ribonucleoside (rNMP)-containing DNA substrates.

218 The structure of the enzyme with a bound ribonucleoside shows that the nucleophilic oxygen atom o

219 ibitor of SLC29A1, nitrobenzylmercaptopurine ribonucleoside, significantly reduced the potency of the

220 ht derivatives of pyrazolo-fused deazapurine ribonucleosides, some of which were weakly fluorescent.

221 Ribonucleosides stabilized by borate mobilize borate and

222 vator 5-aminoimidazole-4-carboxamide1-beta-D-ribonucleoside stimulated AMPK phosphorylation and gluco

223 The benzimidazole D-ribonucleosides TCRB and BDCRB are potent and selective

224 tive N(2)-2',3',5'-tetraacetyl-6-bromopurine ribonucleoside, the synthesis of which is reported here

225 by modifying the 6-position of 7-deazapurine ribonucleosides, the compounds may become selective for

226 the human enzyme is specific for 6-oxopurine ribonucleosides, the Escherichia coli enzyme accepts add

227 he ability of 5-aminoimidazole-4-carboxamide ribonucleoside to suppress ethanol-mediated induction of

228 eversible phosphorolysis of purine (2'-deoxy)ribonucleosides to give the corresponding purine base an

229 reversible phosphorolysis of 2'-deoxypurine ribonucleosides to the free bases and 2-deoxyribose 1-ph

230 termined by deoxyribonucleoside triphosphate/ribonucleoside triphosphate (dNTP/rNTP) ratios, by the a

231 ncentrations and a greater disparity between ribonucleoside triphosphate (rNTP) and dNTP concentratio

232 uired for proviral DNA synthesis whereas the ribonucleoside triphosphate (rNTP) levels remain in the

233 Finally, ribonucleoside triphosphate (rNTP) pools have been shown

234 We measured ribonucleoside triphosphate (rNTP) pools in rat mitochon

235 and cell-free PV synthesis that a pyrimidine ribonucleoside triphosphate analogue (rPTP) with ambiguo

236 t T7 RNA polymerase accepts this fluorescent ribonucleoside triphosphate as a substrate in in vitro t

237 olecules of RNAP under various conditions of ribonucleoside triphosphate concentration, applied load,

238 that, at a consensus promoter, at saturating ribonucleoside triphosphate concentrations, abortive-pro

239 roblasts arrested in response to DNA damage, ribonucleoside triphosphate depletion, and spindle poiso

240 The total time for the synthesis of ribonucleoside triphosphate is approximately 6 days, and

241 Furan-modified ribonucleoside triphosphate is synthesized in two steps

242 The adenosylcobalamin-dependent ribonucleoside triphosphate reductase (RTPR) from Lactob

243 catalytic mechanism of nucleotide reduction, ribonucleoside triphosphate reductase (RTPR) from Lactob

244 The ribonucleoside triphosphate reductase (RTPR) from Lactob

245 Ribonucleoside triphosphate reductase (RTPR) from Lactob

246 oside diphosphate reductase reaction and the ribonucleoside triphosphate reductase reaction with vari

247 Ribonucleoside triphosphate synthesis required PEP as th

248 Binding of a ribonucleoside triphosphate to an RNA polymerase II tran

249 tabolism of oxidoreduction coenzymes, purine ribonucleoside triphosphate, ATP and propanoate, which a

250 e chain of this residue and the 2'-OH of the ribonucleoside triphosphate.

251 synthesis where RNAP accepts two initiating ribonucleoside triphosphates (iNTPs) and performs the fi

252 sis, is allosterically regulated by all four ribonucleoside triphosphates (NTPs) in a nonlinear manne

253 t physiologically relevant concentrations of ribonucleoside triphosphates (NTPs), few MCMs are found.

254 eoxyribonucleoside triphosphates (dNTPs) and ribonucleoside triphosphates (rNTPs) and can use both DN

255 Cellular levels of ribonucleoside triphosphates (rNTPs) are much higher tha

256 Any of the four ribonucleoside triphosphates (rNTPs) can act as precurso

257 e transcriptase (RT) frequently incorporates ribonucleoside triphosphates (rNTPs) during proviral DNA

258 The concentration of ribonucleoside triphosphates (rNTPs) in cells is far gre

259 Replicative DNA polymerases misincorporate ribonucleoside triphosphates (rNTPs) into DNA approximat

260 is compatible with 2'-fluoro-modified (2'F) ribonucleoside triphosphates (rNTPs), which may be inclu

261 and both complementary and noncomplementary ribonucleoside triphosphates (rNTPs).

262 ability to grow in cells with low levels of ribonucleoside triphosphates (rNTPs).

263 The F12A mutant of Dbh incorporates ribonucleoside triphosphates almost as efficiently as de

264 Primers are synthesized from ribonucleoside triphosphates and are four to fifteen nuc

265 ched oligonucleotide primer by incorporating ribonucleoside triphosphates and biotinylated UTP, are i

266 t1p displays broad specificity in converting ribonucleoside triphosphates and deoxynucleoside triphos

267 eferentially interacts with dNTP rather than ribonucleoside triphosphates and initiates RNA as well a

268 tion from P(minor) incorporates nontemplated ribonucleoside triphosphates at the 5' end of the P(mino

269 h in wild-type enzyme fails to guard against ribonucleoside triphosphates incorporation with sufficie

270 Asn-297 is involved in selection of ribonucleoside triphosphates over 2'-dNTPs, a role media

271 illus leichmannii catalyzes the reduction of ribonucleoside triphosphates to deoxyribonucleoside trip

272 hanges include: (i) oxidative degradation of ribonucleoside triphosphates using methylamine at lower

273 tants were isolated and shown to incorporate ribonucleoside triphosphates virtually as efficiently as

274 specificity of T7 RNA polymerase (RNAP) for ribonucleoside triphosphates vs deoxynucleoside triphosp

275 hesize an unnatural polymer from 2'-O-methyl ribonucleoside triphosphates were immobilized and isolat

276 templates, B. subtilis RNA polymerase, four ribonucleoside triphosphates, and the purified B. subtil

277 i) after priming in the presence of the four ribonucleoside triphosphates, or (iv) after complementar

278 it occurs at physiological concentrations of ribonucleoside triphosphates, this reaction may determin

279 eir natural substrates, deoxy- as opposed to ribonucleoside triphosphates, with a selectivity greater

280 itiate DNA chain synthesis in the absence of ribonucleoside triphosphates.

281 e, a component of peptidoglycan, followed by ribonucleoside triphosphates.

282 es as substrate is higher than corresponding ribonucleoside triphosphates.

283 triphosphates, and GTP is the best among the ribonucleoside triphosphates.

284 not compete with transcribing particles for ribonucleoside triphosphates.

285 and by the presence of the DNA primase with ribonucleoside triphosphates.

286 unction of the ambient concentrations of the ribonucleoside triphosphates; and 2), the distribution o

287 ites at which phosphorylation might occur in ribonucleosides under conditions that make it possible,

288 bonucleosides (deoxycytidine) and pyrimidine ribonucleosides (uridine) and is partially NBMPR-sensiti

289 e first example of a conformationally locked ribonucleoside version in the Southern hemisphere.

290 The structure of the 5-fluoroimidazole ribonucleoside was confirmed by X-ray crystallography an

291 vity against HCMV of the dihalobenzimidazole ribonucleosides was I approximately equal to Br approxim

292 via steady-state kinetics and PCR, while the ribonucleosides were characterized by the transcription

293 ']thieno[2',3':4,5]pyrrolo[2,3-d]pyrimidine) ribonucleosides were designed and synthesized.

294 Inexpensive ribonucleosides were used as starting materials.

295 is a member of a new class of benzimidazole ribonucleosides which inhibit human cytomegalovirus (HCM

296 In contrast to 2'-OH-containing pyrimidine ribonucleosides, which rely upon uridine-cytidine kinase

297 eric oligonucleotides with 2'-O-methoxyethyl ribonucleoside wings and a central DNA phosphorothioate

298 The reaction of these novel ribonucleosides with 1-pyrenecarboxaldehyde results in t

299 ence, the conjugation of 2'-O-aminooxymethyl ribonucleosides with aldehydes, including those generate

300 Screening of 7-(het)aryl-7-deazaadenine ribonucleosides with Mtb and human (h) ADKs and testing