ライフサイエンスコーパス: ribonucleotide reductase

1 vating catalysts in numerous enzymes such as ribonucleotide reductase.

2 deoxyribonucleoside diphosphates (dNDPs) by ribonucleotide reductase.

3 2 substitutes for protein R2 as a subunit of ribonucleotide reductase.

4 HSV mutations in ICP6, the large subunit of ribonucleotide reductase.

5 as it does in eukaryotes, via inhibition of ribonucleotide reductase.

6 ation is through subcellular localization of ribonucleotide reductase.

7 disulfide reduction and electron donation to ribonucleotide reductase.

8 ease of dGTP due to allosteric regulation of ribonucleotide reductase.

9 G levels and expression of the p53-inducible ribonucleotide reductase.

10 akin to the tyrosine dyad (Y730 and Y731) of ribonucleotide reductase.

11 xposure to hydroxyurea (HU), an inhibitor of ribonucleotide reductase.

12 nome of Escherichia coli encodes two class I ribonucleotide reductases.

13 nown mechanisms of upregulated expression of ribonucleotide reductase, 14-3-3sigma expression is dram

14 nscription factor A (TFAM) and p53-inducible ribonucleotide reductase 2 (p53R2), which are involved i

15 The gene encoding ribonucleotide reductase 3 (RNR3) is strongly induced in

16 The Sml1 protein inhibits ribonucleotide reductase activity by binding to the R1 s

17 On the other hand, the ribonucleotide reductase activity increases at the corre

18 We have identified ribonucleotide reductase activity specifically associate

19 port a new mechanism for regulation of yeast ribonucleotide reductase activity that occurs during iro

20 l2 reduces intracellular dNTPs by inhibiting ribonucleotide reductase activity, thereby providing ins

21 These different viral ribonucleotide reductases also caused relocalization of

22 lating the expression of the RNR2 subunit of ribonucleotide reductase, an enzyme essential for the re

23 at low doses of hydroxyurea, an inhibitor of ribonucleotide reductase and an important drug in the tr

24 Combined inhibition of ribonucleotide reductase and deoxycytidine kinase (dCK)

25 n are respectively complemented by mammalian ribonucleotide reductase and GADD34, whose genes are exp

26 ext two deal with specific cases, the enzyme ribonucleotide reductase and iron/manganese homeostasis

27 RRM1 encodes the regulatory subunit of ribonucleotide reductase and is a molecular target of ge

28 sidue that is structurally conserved in both ribonucleotide reductase and mycobacterial putative acyl

29 on of the gene encoding the small subunit of ribonucleotide reductase and of the K3L gene to allow ad

30 Grx1 efficiently reduces ribonucleotide reductase and PAPS reductase, while Grx3

31 Since hydroxyurea inhibits ribonucleotide reductase and reduces intracellular deoxy

32 It inhibits ribonucleotide reductase and reversibly arrests cells in

33 likely involves the allosteric regulation of ribonucleotide reductase and severe limitations of the d

34 these types of altered growth and mammalian ribonucleotide reductase and topoisomerases are targets

35 educing equivalents for cofactor assembly in ribonucleotide reductases and highlight issues associate

36 ut with hydroxyurea (HU), thereby inhibiting ribonucleotide reductase, and bringing about damage-inde

37 nt thymidylate synthase, thymidylate kinase, ribonucleotide reductase, and deoxycytidylate deaminase,

38 active site similar to that in hemerythrin, ribonucleotide reductase, and methane monooxygenase, all

39 . patens proliferating cell nuclear antigen, ribonucleotide reductase, and minichromosome maintenance

40 ers may inhibit thymidylate synthase (TS) or ribonucleotide reductase, and the nucleoside/nucleobase

41 uene monooxygenases, bacterial and mammalian ribonucleotide reductases, and stearoyl acyl carrier pro

42 lux backbone appears to buffer deficiency in ribonucleotide reductase by enabling a compensatory incr

43 R2) subunit of the class 1a Escherichia coli ribonucleotide reductases by reaction with O2 followed b

44 The class I ribonucleotide reductases catalyze the conversion of nuc

45 Ribonucleotide reductase catalyzes a crucial step in de

46 E. coli ribonucleotide reductase catalyzes the reduction of nucl

47 rotein known to produce DNA building blocks (ribonucleotide reductase) causes A3B to relocalize from

48 de the large and small subunits of the human ribonucleotide reductase complex, respectively, markedly

49 ivated the ICP6 gene (UL39, large subunit of ribonucleotide reductase), constructing ICP6 mutants wit

50 We also show that the activity of ribonucleotide reductase decreases in hypoxia in cells e

51 emcitabine incubation irreversibly inhibited ribonucleotide reductase, depleting dNTPs, resulting in

52 The synthetic enzymes ribonucleotide reductase, dihydrofolate reductase, and t

53 failure to mediate histone deacetylation of ribonucleotide reductase, dihydrofolate reductase, and t

54 n Deltalon results from higher expression of ribonucleotide reductase driven by increased CcrM.

55 physiologically relevant electron donor for ribonucleotide reductase during DNA precursor synthesis.

56 cluding those formed in the essential enzyme ribonucleotide reductase during its action on substrates

57 and that negative feedback between dATP and ribonucleotide reductase ensures tight control of dNTP c

58 d mass spectrometry, we identified RRM2 (the ribonucleotide reductase family member 2) as an interact

59 r, a "missing link" intermediary form of the ribonucleotide reductase family, vestigial pi-helices, a

60 esis is further complicated by the lack of a ribonucleotide reductase for the conversion of nucleosid

61 The class Ic ribonucleotide reductase from Chlamydia trachomatis ( Ct

62 tly reported that the R2 subunit of class Ic ribonucleotide reductase from Chlamydia trachomatis cont

63 the essential cofactor in the R2 subunit of ribonucleotide reductase from mouse.

64 tructures of the eukaryotic alpha subunit of ribonucleotide reductase from Saccharomyces cerevisiae.

65 We recently showed that the class Ic ribonucleotide reductase from the human pathogen Chlamyd

66 se mutations in viral ICP6 (encoding a viral ribonucleotide reductase function) and/or gamma34.5 func

67 iron(II/II) cluster in protein R2 of class I ribonucleotide reductase generates the enzyme's essentia

68 s of deletion mutants, titratable alleles of ribonucleotide reductase genes, and measurements of intr

69 o Crt1, the repressor of model MMS-inducible ribonucleotide reductase genes, was found not to play a

70 many DNA damage induced genes, including the ribonucleotide reductase genes, which regulate cellular

71 untranslated region of an operon containing ribonucleotide reductase genes.

72 kinase, or deletion of the Spd1 inhibitor of ribonucleotide reductase has little additional effect on

73 work by Wang et al. (2014), reveal that HSV ribonucleotide reductase has opposing activities in eith

74 We conclude that the regulatory subunit of ribonucleotide reductase has tumor suppressor activity t

75 The genes encoding ribonucleotide reductase have been recently shown to be

76 Human ribonucleotide reductases (hRNRs) catalyze the conversio

77 Human ribonucleotide reductase (hRR) is crucial for DNA replic

78 on, thus eliminating inducible expression of ribonucleotide reductase in mec1-21, rates of spontaneou

79 lear recruitment suggests an active role for ribonucleotide reductase in the cellular response to CPT

80 ts ability to serve as an electron donor for ribonucleotide reductase in vitro.

81 and likely repair of the metallocofactor of ribonucleotide reductases in both bacteria and the buddi

82 an indirect effect of altered regulation of ribonucleotide reductase induced by HU.

83 hda strain and hda(+) strains exposed to the ribonucleotide reductase inhibitor hydroxyurea.

84 idine-2-carboxaldehyde thiosemicarbazone), a ribonucleotide reductase inhibitor, has been extensively

85 at the response to BrdU is influenced by the ribonucleotide reductase inhibitor, Spd1, suggesting tha

86 itabine was used in combination with another ribonucleotide reductase inhibitor.

87 Ribonucleotide reductase inhibitors such as gemcitabine

88 t forms noncanonical base pairs with certain ribonucleotide reductase inhibitors.

89 Escherichia coli ribonucleotide reductase is an alpha2beta2 complex and c

90 Escherichia coli ribonucleotide reductase is an alpha2beta2 complex that

91 The nucleotide metabolism enzyme ribonucleotide reductase is composed of a regulatory sub

92 Escherichia coli class Ia ribonucleotide reductase is composed of two subunits (al

93 The essential catalytic radical of Class-I ribonucleotide reductase is generated and delivered by p

94 The rate-limiting enzyme of dNTP synthesis, ribonucleotide reductase, is inhibited by endogenous lev

95 ion the only known fragmented form of an OPV ribonucleotide reductase large subunit gene.

96 unoprecipitation experiments showed that the ribonucleotide reductase large subunit of EBV, BORF2(6,7

97 The HSV ribonucleotide reductase large subunit R1 was sufficient

98 uctures that are induced by ORF61, the viral ribonucleotide reductase large subunit.

99 Its molecular targets are ribonucleotide reductase M1 (RRM1) and elongating DNA.

100 ciency, complementation group 1 (ERCC1), and ribonucleotide reductase M1 (RRM1) expression levels hav

101 overcomes gemcitabine resistance related to ribonucleotide reductase M1 over-expression.

102 A analysis showed a strong increase of rrm1 (ribonucleotide reductase M1) expression in the resistant

103 vealed that the TC-1-GR cells over-expressed ribonucleotide reductase M1, which was likely the cause

104 Ribonucleotide reductase maintains cellular deoxyribonuc

105 ible protein (hli), transaldolase (talC) and ribonucleotide reductase (nrd)--are transcribed together

106 ates the transcription of the genes encoding ribonucleotide reductase (nrdAB).

107 The class Ib ribonucleotide reductase of Escherichia coli can initiat

108 The class Ia ribonucleotide reductase of Escherichia coli requires st

109 Here, we report that p53-inducible ribonucleotide reductase (p53R2/RRM2B) is a robust trans

110 Photochemical ribonucleotide reductases (photoRNRs) have been develope

111 is a natural product that inhibits cellular ribonucleotide reductase, prolonging the S phase of the

112 ystem II, the phytochrome photoreceptor, and ribonucleotide reductase R2 illustrate the power and ver

113 These are the class Ic ribonucleotide reductase R2 proteins and a group of oxid

114 , very similar to the active site of class I ribonucleotide reductase (R2) providing open coordinatio

115 homologous to the small subunit of class Ic ribonucleotide reductase (R2c) but has a completely diff

116 tor is present in the R2 subunit of class Ic ribonucleotide reductases (R2c) and in R2-like ligand-bi

117 th pharmacological and genetic inhibition of ribonucleotide reductase regulatory subunit M2 (RRM2), a

118 ecular docking analysis identified the RRM2 (ribonucleotide reductase regulatory subunit M2) of RNR a

119 Ribonucleotide reductase, responsible for the de novo sy

120 valence concentrations at which DFP inhibits ribonucleotide reductase (RNR) activities and/or reduces

121 e beta protein (betaC19) of Escherichia coli ribonucleotide reductase (RNR) allows for the temporal m

122 y of their respective rate-limiting enzymes, ribonucleotide reductase (RNR) and deoxycytidine kinase

123 Ribonucleotide reductase (RNR) and deoxycytidylate deami

124 ate synthase, dihydrofolate (DHF) reductase, ribonucleotide reductase (RNR) and Escherichia coli nucl

125 3-fluorotyrosine (3-FY) in the R2 subunit of ribonucleotide reductase (RNR) and present the EPR spect

126 The expression of genes encoding the ribonucleotide reductase (RNR) and proteins that facilit

127 ino acid radicals [photosystem II (PSII) and ribonucleotide reductase (RNR) as compared to tyrosine-m

128 The reaction of a class I ribonucleotide reductase (RNR) begins when a cofactor in

129 Catalysis by a class I ribonucleotide reductase (RNR) begins when a cysteine (C

130 ates accumulate during activation of class I ribonucleotide reductase (RNR) beta subunits, which self

131 Ribonucleotide reductase (RNR) catalyzes conversion of n

132 Ribonucleotide reductase (RNR) catalyzes reduction of th

133 Ribonucleotide reductase (RNR) catalyzes the conversion

134 Ribonucleotide reductase (RNR) catalyzes the conversion

135 Escherichia coli class I ribonucleotide reductase (RNR) catalyzes the conversion

136 Bacillus subtilis class Ib ribonucleotide reductase (RNR) catalyzes the conversion

137 E. coli ribonucleotide reductase (RNR) catalyzes the conversion

138 Ribonucleotide reductase (RNR) catalyzes the conversion

139 Ribonucleotide reductase (RNR) catalyzes the conversion

140 Ribonucleotide reductase (RNR) catalyzes the conversion

141 Ribonucleotide reductase (RNR) catalyzes the de novo syn

142 Ribonucleotide reductase (RNR) catalyzes the first commi

143 Ribonucleotide reductase (RNR) catalyzes the formation o

144 E. coli ribonucleotide reductase (RNR) catalyzes the production

145 Ribonucleotide reductase (RNR) catalyzes the rate-limiti

146 Ribonucleotide reductase (RNR) catalyzes the rate-limiti

147 Ribonucleotide reductase (RNR) catalyzes the rate-limiti

148 Ribonucleotide reductase (RNR) catalyzes the rate-limiti

149 Ribonucleotide reductase (RNR) catalyzes the reduction o

150 Escherichia coli ribonucleotide reductase (RNR) catalyzes the reduction o

151 Ribonucleotide reductase (RNR) catalyzes the reduction o

152 Ribonucleotide reductase (RNR) catalyzes the reduction o

153 mutations that increase the activity of the ribonucleotide reductase (RNR) complex.

154 The beta(2) subunit of class Ia ribonucleotide reductase (RNR) contains a diferric tyros

155 Escherichia coli class Ib ribonucleotide reductase (RNR) converts nucleoside 5'-di

156 Ribonucleotide reductase (RNR) converts ribonucleotides

157 Escherichia coli class Ia ribonucleotide reductase (RNR) converts ribonucleotides

158 A class Ia ribonucleotide reductase (RNR) employs a mu-oxo-Fe2(III/

159 A conventional class I (subclass a or b) ribonucleotide reductase (RNR) employs a tyrosyl radical

160 The ribonucleotide reductase (RNR) enzyme catalyzes an essen

161 (DTNB), and the manganese-containing type Ib ribonucleotide reductase (RNR) from B. anthracis in the

162 The class Ic ribonucleotide reductase (RNR) from Chlamydia trachomati

163 The class Ia ribonucleotide reductase (RNR) from Escherichia coli emp

164 22.) production in the R2 subunit of class I ribonucleotide reductase (RNR) from Escherichia coli.

165 Ribonucleotide reductase (RNR) from Lactobacillus leichm

166 We recently showed that the class Ic ribonucleotide reductase (RNR) from the human pathogen C

167 ed a novel function for Rap1, regulating the ribonucleotide reductase (RNR) genes that are required f

168 n the alpha2 (R1) subunit of class I E. coli ribonucleotide reductase (RNR) has been investigated by

169 The small subunit (beta2) of class Ia ribonucleotide reductase (RNR) houses a diferric tyrosyl

170 estigated for 2 and 5, including the role of ribonucleotide reductase (RNR) inhibition, endoplasmic r

171 t does not suppress their sensitivity to the ribonucleotide reductase (RNR) inhibitor hydroxyurea (HU

172 ture studies of the class I Escherichia coli ribonucleotide reductase (RNR) intermediate X and three

173 Ribonucleotide reductase (RNR) is a central enzyme for t

174 Ribonucleotide reductase (RnR) is a key enzyme synthesiz

175 The beta(2) subunit of a class Ia or Ib ribonucleotide reductase (RNR) is activated when its car

176 Ribonucleotide reductase (RNR) is an attractive target f

177 Ribonucleotide reductase (RNR) is an essential iron-depe

178 Regulation of ribonucleotide reductase (RNR) is important for cell sur

179 Ribonucleotide reductase (RNR) is the only enzyme capabl

180 Ribonucleotide reductase (RNR) is the rate-limiting enzy

181 The enzyme ribonucleotide reductase (RNR) plays a critical role in

182 Ribonucleotide reductase (RNR) provides the only de novo

183 Substrate turnover in class Ia ribonucleotide reductase (RNR) requires reversible radic

184 53R2 (hp53R2) is a 351-residue p53-inducible ribonucleotide reductase (RNR) small subunit.

185 that MI-63 suppressed the expression of the ribonucleotide reductase (RNR) subunit M2 (RRM2).

186 Ribonucleotide reductase (RNR) supplies the balanced poo

187 b1-Cul4(Cdt)(2) ubiquitin ligase complex and ribonucleotide reductase (RNR) to be required for HR rep

188 Many pathogenic organisms require class Ib ribonucleotide reductase (RNR) to catalyze the conversio

189 The di-iron enzyme ribonucleotide reductase (RNR) uses a diferric-tyrosyl r

190 A class I ribonucleotide reductase (RNR) uses either a tyrosyl rad

191 cifically incorporated into E. coli class Ia ribonucleotide reductase (RNR) using the recently evolve

192 ive copies of nrdB, encoding beta-subunit of ribonucleotide reductase (RNR), a critical enzyme involv

193 In a conventional class I ribonucleotide reductase (RNR), a diiron(II/II) cofactor

194 This reduction is catalyzed by ribonucleotide reductase (RNR), a heterodimeric tetramer

195 se heart and skeletal muscle by inactivating ribonucleotide reductase (RNR), a key enzyme for the de

196 In class 1a ribonucleotide reductase (RNR), a substrate-based radica

197 Escherichia coli ribonucleotide reductase (RNR), an alpha2beta2 complex,

198 mic proteins, including the essential enzyme ribonucleotide reductase (RNR), are maintained in the re

199 The Escherichia coli ribonucleotide reductase (RNR), composed of two subunits

200 Ribonucleotide reductase (RNR), comprising two large (R1

201 Ribonucleotide reductase (RNR), containing regulatory hR

202 droxyurea (HU) specifically inhibits class I ribonucleotide reductase (RNR), depleting dNTP pools and

203 of dNTP biosynthesis in mammals, the enzyme ribonucleotide reductase (RNR), impacts cancer susceptib

204 nsfer (ET) reactions of photosystem (PS) II, ribonucleotide reductase (RNR), photolyase, and many oth

205 The class Ia ribonucleotide reductase (RNR), the product of the nrdAB

206 Hydroxyurea (HU) inhibits ribonucleotide reductase (RNR), which catalyzes the rate

207 Ribonucleotide reductase (RNR), which is a heterodimeric

208 Rather, an imbalance in ribonucleotide reductase (RNR), which is induced by 5-FO

209 A new example is Epstein-Barr virus (EBV) ribonucleotide reductase (RNR)-mediated inhibition of ce

210 y step in the catalytic reaction of class Ia ribonucleotide reductase (RNR).

211 tor of the beta2 subunit of Escherichia coli ribonucleotide reductase (RNR).

212 adical transport in Escherichia coli class I ribonucleotide reductase (RNR).

213 at are maintained primarily by regulation of ribonucleotide reductase (RNR).

214 and lowest in G1 phase and is controlled by ribonucleotide reductase (RNR).

215 bonucleotides (dNTPs), which are produced by ribonucleotide reductase (RNR).

216 his control is exerted through regulation of ribonucleotide reductase (RNR).

217 dNTP) pools, which are strictly regulated by ribonucleotide reductase (RNR).

218 stems primarily from the inhibition of human ribonucleotide reductase (RNR).

219 Ribonucleotide reductase (RNR, 76 kDa) from Lactobacillu

220 Ribonucleotide reductases (RNR) catalyze the rate-limiti

221 Ribonucleotide reductases (RNR) catalyze the reduction o

222 The beta2 subunit of class Ia ribonucleotide reductases (RNR) contains an antiferromag

223 plication and DNA repair and is catalyzed by ribonucleotide reductases (RNR), which convert ribonucle

224 anslation elongation factor 3 (YEF3) and the ribonucleotide reductase (RNR1 and RNR3) large subunits

225 easing nucleotide pools by overexpression of ribonucleotide reductase (RNR1) suppressed mtDNA replica

226 ithin the gene encoding the large subunit of ribonucleotide reductase (RNR1), the enzyme that catalys

227 The gene encoding a large subunit of ribonucleotide reductase, RNR3, is regulated by ISW2 and

228 Ribonucleotide reductases (RNRs) are a diverse family of

229 Ribonucleotide reductases (RNRs) are ancient enzymes tha

230 The class I ribonucleotide reductases (RNRs) are composed of two hom

231 Ribonucleotide reductases (RNRs) are essential enzymes r

232 Eukaryotic ribonucleotide reductases (RNRs) are Fe-dependent enzyme

233 The class III ribonucleotide reductases (RNRs) are glycyl radical (G*)

234 Ribonucleotide reductases (RNRs) are required for the sy

235 The class I ribonucleotide reductases (RNRs) catalyze the conversion

236 Ribonucleotide reductases (RNRs) catalyze the conversion

237 Ribonucleotide reductases (RNRs) catalyze the conversion

238 Ribonucleotide reductases (RNRs) catalyze the conversion

239 Ribonucleotide reductases (RNRs) catalyze the conversion

240 Ribonucleotide reductases (RNRs) catalyze the conversion

241 Ribonucleotide reductases (RNRs) catalyze the conversion

242 Ribonucleotide reductases (RNRs) catalyze the de novo co

243 Ribonucleotide reductases (RNRs) catalyze the only pathw

244 Ribonucleotide reductases (RNRs) catalyze the reduction

245 Essential for DNA biosynthesis and repair, ribonucleotide reductases (RNRs) convert ribonucleotides

246 A fascinating discovery in the chemistry of ribonucleotide reductases (RNRs) has been the identifica

247 Eukaryotic ribonucleotide reductases (RNRs) require a diferric-tyro

248 The class III anaerobic ribonucleotide reductases (RNRs) studied to date couple

249 s Ib (NrdEF) and anaerobic class III (NrdDG) ribonucleotide reductases (RNRs) that perform the essent

250 Ribonucleotide reductases (RNRs) use a conserved radical

251 Class Ib ribonucleotide reductases (RNRs) use a dimanganese-tyros

252 Ribonucleotide reductases (RNRs) utilize radical chemist

253 phosphate (F(2)CDP) is a potent inhibitor of ribonucleotide reductases (RNRs), enzymes that convert n

254 Ribonucleotide reductases (RNRs), which catalyze the con

255 and deoxynucleotide production catalyzed by ribonucleotide reductases (RNRs).

256 p53R2 is a newly identified small subunit of ribonucleotide reductase (RR) and plays a key role in su

257 Eukaryotic ribonucleotide reductase (RR) catalyzes nucleoside dipho

258 Ribonucleotide reductase (RR) catalyzes the rate-limitin

259 Inhibition of ribonucleotide reductase (RR) decreased the radiocarbon

260 Ribonucleotide reductase (RR) is a highly regulated enzy

261 We recently found that the ribonucleotide reductase (RR) subunit M2 is potentially

262 ath pathways using the large subunit (R1) of ribonucleotide reductase (RR) to suppress apoptosis by b

263 dicted interaction between EBV BPLF1 and EBV ribonucleotide reductase (RR), a functional clone of the

264 ors targeting transferrin receptor (TfR) and ribonucleotide reductase (RR), is proven to be effective

265 intertwined roles for ATM: the regulation of ribonucleotide reductase (RR), the rate-limiting enzyme

266 underexpressed thymidylate synthase (TS) and ribonucleotide reductase (RR), two enzymes required for

267 roduct (ERCC1) and the regulatory subunit of ribonucleotide reductase (RRM1) have been reported as be

268 th the specific messenger RNA (M2 subunit of ribonucleotide reductase (RRM2)) and the protein (RRM2)

269 Ribonucleotide reductases (RRs) catalyze the rate-limiti

270 Eukaryotic class I ribonucleotide reductases (RRs) generate deoxyribonucleo

271 ne non-redundant homologous genes, including ribonucleotide reductase small subunit (a gene conserved

272 Ribonucleotide reductase small subunit B (RRM2B) is a st

273 Ribonucleotide reductase small subunit p53R2 was identif

274 p53R2, which is one of the two known ribonucleotide reductase small subunits (the other being

275 Ribonucleotide reductase subunit 1 (RRM1) is crucial for

276 r 1 (hENT1), deoxycytidine kinase (dCK), and ribonucleotide reductase subunit 1 (RRM1).

277 protein VP22 (encoded by the UL49 gene), and ribonucleotide reductase subunit 2 protein (RR2; encoded

278 lved in nucleotide metabolism, including the ribonucleotide reductase subunit cdc22 and phosphate- an

279 c delivery of a siRNA nanoparticle targeting ribonucleotide reductase subunit M2 (RRM2), and evaluate

280 Overexpression of ribonucleotide reductase subunit M2 (RRM2), involved in

281 Ribonucleotide reductase subunit RRM2B (p53R2) has been

282 by mass spectrometry revealed R1, the large ribonucleotide reductase subunit, in purified mitochondr

283 We show that RRM2, a ribonucleotide reductase subunit, is the target of this

284 The effects of siRNA-mediated knockdown of ribonucleotide reductase subunit-2 (RRM2), a rate-limiti

285 d the Rad53 checkpoint-mediated induction of ribonucleotide reductase subunits Rnr1 and Rnr3, thereby

286 Ribonucleotide reductases supply cells with their deoxyr

287 ansgenic mouse that overexpresses the enzyme ribonucleotide reductase (TgRR), which catalyzes the rat

288 d cellular targets is the beta(2) subunit of ribonucleotide reductase that requires a diferric-tyrosy

289 ential cofactor for non-heme enzymes such as ribonucleotide reductase, the limiting enzyme for DNA sy

290 is the DNA damage-inducible small subunit of ribonucleotide reductase, the rate-limiting enzyme in de

291 We individually down-regulated p53R2 ribonucleotide reductase, thymidine kinase 2, and deoxyg

292 otide triphosphates (dNTPs) and instead uses ribonucleotide reductase to convert imported ribonucleot

293 ntaining a siRNA targeting the M2 subunit of ribonucleotide reductase to non-human primates are repor

294 otoxicity using hydroxyurea, an inhibitor of ribonucleotide reductase, to decrease the endogenous dGT

295 356 of the small subunit of Escherichia coli ribonucleotide reductase using EPL.

296 s in the R2 subunit of Chlamydia trachomatis ribonucleotide reductase using x-ray absorption spectros

297 S phase, and DNA polymerase-alpha, PCNA, and ribonucleotide reductase, which are essential for the in

298 siae by depleting Rnr1, the major subunit of ribonucleotide reductase, which converts ribonucleotides

299 function as the electron donor for class Ib ribonucleotide reductases, which convert ribonucleotides

300 rofolate reductase, thymidylate synthase and ribonucleotide reductase, while also spotlighting new en