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1 uitin ligase that ubiquitinates sites on the ribosomal 40S subunit to initiate pathways of mRNA and p
2 ection of correct aminoacyl (aa)-tRNA at the ribosomal A site is fundamental to maintaining translati
3 of noncognate ternary complexes (TCs) at the ribosomal A-site enhances the dissociation rate of such
10 somal binding might be due to cis-regulatory ribosomal binding and to defective ribosomal scanning of
14 ow how the specific location of each agent's ribosomal binding site affects the long-term distributio
15 have revealed both increased exposure of the ribosomal binding site and increased ribosomal binding t
16 of the ribosomal binding site and increased ribosomal binding to the ompA transcript at permissive t
18 hase of the training period, suggesting that ribosomal biogenesis regulates the dose-response relatio
21 tinction allows us to quantify the extent of ribosomal collisions along the transcript and identify i
24 ur results suggest that VIG1 is an ancillary ribosomal component and plays a role in sRNA-mediated tr
26 Moreover, we reveal IFN-dependent changes in ribosomal composition that act to buffer IFN-stimulated
27 g cognate tRNA upon initial recognition, the ribosomal decoding centre dynamically monitors codon-ant
28 ot epidermal cell fate switch in response to ribosomal defects and, more generally, it demonstrates a
29 or G3BP1 family proteins increased lysosomal ribosomal degradation and perturbed ribosomal subunit st
30 eristic of the disease, which is a model for ribosomal diseases, related to a heterozygous allelic va
34 activation of Hog1 is linked to a defect in ribosomal DNA (rDNA) and telomere segregation, and it ul
38 binds to a specific upstream element in the ribosomal DNA (rDNA) promoter and interacts with two oth
39 In this assay, multicopy small-subunit (SSU) ribosomal DNA (rDNA) sequences were used as targets.
48 features of the PCBP2/SLIV complex vital for ribosomal docking, and the way in which this key functio
50 fic interaction of the Not5 subunit with the ribosomal E-site in Saccharomyces cerevisiae This intera
51 of structured RNA sequences, called Internal Ribosomal Entry Sites (IRES), in viral RNAs is a widespr
52 egulated profiles, including translation and ribosomal events in spindle, inflammation- and apical ju
55 nic stages, with nearly 500 million putative ribosomal footprints mapped to mRNAs, and compare them t
56 e a molecular mechanism called programmed -1 ribosomal frameshift (-1 PRF) to control the relative ex
57 rved RNA elements located at the 5' end, the ribosomal frameshift segment and the 3'-untranslated reg
60 biochemical mechanisms, including programmed ribosomal frameshifting (PRF), which facilitates the pro
61 ved mechanism to influence the efficiency of ribosomal frameshifting during translation of viral RNA,
63 domic analyses demonstrated the induction of ribosomal frameshifting, and the generation and presenta
65 bone marrow failure syndrome associated with ribosomal gene mutations that lead to ribosomal insuffic
67 we analyze RNAP number distribution data for ribosomal genes in Saccharomyces cerevisiae from three p
69 t labeling, flow cytometry and Cre-dependent ribosomal immunoprecipitations, we describe P2ry12-CreER
72 nd off the ribosome, their results show that ribosomal interactions have little impact on the folding
73 NA modification state, and structures of 40S ribosomal intermediates that form upon SrmB deletion.
74 approaches for taxonomic assertions based on ribosomal internal transcribed spacer regions (ITS1/2) a
75 7 single copy nuclear genes, and the nuclear ribosomal ITS from 29 species representing all but one t
76 he poliovirus type I IRES is able to recruit ribosomal machinery only in the presence of host factor
77 des have revealed major growth laws relating ribosomal mass fraction and cell size to the growth rate
78 the aminoglycoside-modifying enzymes and the ribosomal methyltransferases whose widespread presence s
79 Synthesis defects are rescued by various ribosomal mutations, as well as by reducing cellular rib
80 l transcribed spacer region 2 of the nuclear ribosomal operon to identify the fungal species present.
83 nally modified peptides (RiPPs), also called ribosomal peptide natural products (RPNPs), form a growi
84 e type I, polyketide synthase type II or non-ribosomal peptide synthase genes within their genome.
85 In vitro assays reveal two single-module non-ribosomal peptide synthetases (NRPs) that incorporate th
89 from non-canonical translation of defective ribosomal products, relate this to the dysregulated tran
94 ed a transgene that expresses an eGFP-tagged ribosomal protein (L10a) under the control of the macrop
97 wild-type cells and cells with mutations in ribosomal protein (Rp) genes in Drosophila melanogaster.
98 ls, TOR specifically promotes translation of ribosomal protein (RP) mRNAs when amino acids are availa
99 d Mrt4 that prevent premature loading of the ribosomal protein eL24, the protein-folding machinery at
100 translated proteins but also at the level of ribosomal protein expression, ribosome assembly, and rib
101 is report, we analyzed the eight-member uL18 ribosomal protein family in Arabidopsis uL18 proteins sh
103 tern of enrichment around the start codon of ribosomal protein genes in all stages but male gametocyt
104 eterozygous allelic variation in 1 of the 20 ribosomal protein genes of either the small or large rib
105 ith wide nucleosome-deficient regions (e.g., ribosomal protein genes), known to harbor partially-unwr
107 n in bacterial 23S rRNA is directly bound by ribosomal protein L11, and this complex is essential to
108 d identifies a G70D mutation in the RplD 50S ribosomal protein L4 as significantly associated with in
109 d protein synthesis requires isoforms of the ribosomal protein L4 encoded by the cytokinin-inducible
111 ould inhibit trans-translation by binding to Ribosomal protein S1 (RpsA) and competing with tmRNA, th
113 raction between the translation enhancer and ribosomal protein S1 to repress translation of manY mRNA
114 atterns of three putative dual-coding genes, ribosomal protein S12 (RPS12), the 5' editing domain of
116 Differential expression of the RPS27L (40S ribosomal protein S27-like) gene, part of the p53/mammal
119 ma model in which constitutive activation of ribosomal protein S6 kinase A1 drives tumor invasion.
122 educed constitutive activation of the mTORC1/ribosomal protein S6 pathway and downregulated constitut
123 1(Thr412) , 19%; p70 S6K1(Thr389) , 58%) and ribosomal protein S6(Ser235/236) (37%), greater rested-s
125 umber of rRNA genes, and codon usage bias in ribosomal protein sequences were all higher in the ferti
126 his drug across glioma cell lines, revealing ribosomal protein subunit RPS11, 16, and 18 as putative
127 slation-related proteins such as 50S and 30S ribosomal protein subunit variants and elongation factor
130 e functions of two NPET-associated proteins, ribosomal protein uL4 and assembly factor Nog1, in NPET
132 tants deficient in PSRP7, a plastid-specific ribosomal protein, OTP86, an RNA editing factor, and cpP
135 rsions of OVA model Ags displaying defective ribosomal protein-dependent and -independent Ag presenta
136 ts to silence Phytoene desaturase (PDS) or a ribosomal protein-encoding gene, RPL10 (QM), in Nicotian
137 or margin were associated with expression of ribosomal proteins (false discovery rate <0.25; NES, 1.9
138 n genome, many nuclear-encoded mitochondrial ribosomal proteins (MRPs) are required for proper functi
139 f the mitoribosome reveals an assembly of 94-ribosomal proteins and four-rRNAs with an additional pro
140 in hippocampal neurons resulted in increased ribosomal proteins and initiation factors, but decreased
142 environmental effects is challenging because ribosomal proteins and rRNA preclude most spectroscopic
143 f 5'TOP mRNAs, which includes mRNAs encoding ribosomal proteins and several translation factors.
144 ith significantly lower expression levels of ribosomal proteins and transcriptional and translational
148 How stable proteins that rely on defective ribosomal proteins for direct presentation are captured
149 eveals that the RNA-binding capacity of uL18 ribosomal proteins has been repurposed to create factors
152 y, coordinated translational upregulation of ribosomal proteins only occurred in the liver but not in
153 equences that follow genetic knockout of the ribosomal proteins RPS25 or RACK1 in a human cell line,
154 ient mutants, NMD-susceptible transcripts of ribosomal proteins that are known for their role as nonc
156 transcription, recovery of transcription of ribosomal proteins, and initiation of wound healing and
157 oroplast protein chaperone machinery and 70S ribosomal proteins, but other parts of the proteostasis
158 rganisms live longer when they lack specific ribosomal proteins, especially of the large 60S subunit
159 mes; to accomplish this task, ribosomes make ribosomal proteins, polymerases, enzymes, and signaling
160 ession of pre-ribosomal RNAs (pre-rRNAs) and ribosomal proteins, pre-rRNA processing, and subunit ass
161 tide and thioamide backbone substitutions in ribosomal proteins, the former likely conserved in all d
162 avoidance of host transcripts encoding host ribosomal proteins, which are required by IAV for replic
163 n the phylogenies of both 16S rRNA genes and ribosomal proteins, which we propose to name (U)Petromon
164 osomal ubiquitylation (RRub) on distinct 40S ribosomal proteins, yet the cellular role and fate of ub
171 o remodeling of ribosomes, in which multiple ribosomal (r-) proteins containing the zinc-binding CXXC
172 s a less-known function to induce eukaryotic ribosomal readthrough of PTCs to produce a full-length p
173 grity of the base pair helps to modulate the ribosomal response to regulatory nascent peptides, deter
174 terized them by partially sequencing the 16s ribosomal ribonucleic acid (rrs), flagellin (flaB), and
177 ucturally conserved domain that binds the 5S ribosomal RNA (rRNA) and allows its incorporation into r
181 : see text] bound to the ribosome reveal 23S ribosomal RNA (rRNA) nucleotide A1913 positional changes
182 side chain of macrolides interacts with 23S ribosomal RNA (rRNA) nucleotides A752 and U2609, that we
183 ng residue networks (sectors) within the 23S ribosomal RNA (rRNA) of the large ribosomal subunit.
188 A-seq requires efficient physical removal of ribosomal RNA (rRNA), which otherwise dominates transcri
189 tudy, we evaluated two methods for preparing ribosomal RNA (rRNA)-depleted sequencing libraries for R
193 Virgin Islands, amplifying the large-subunit ribosomal RNA and psbA protein D1 marker genes, revealed
199 o evaluate the diagnostic performance of 16S ribosomal RNA gene (rRNA) polymerase chain reaction (PCR
204 Feces were collected and analyzed by 16S ribosomal RNA gene sequencing and bacterial community an
205 lysis of fecal microbiota composition by 16S ribosomal RNA gene sequencing and fecal/urinary metaboli
212 ntitative polymerase chain reaction, and 16S ribosomal RNA gene sequencing; lamina propria and mesent
215 hibitor of RNA polymerase I transcription of ribosomal RNA genes (rDNA), induces replication stress a
216 rearrangements among the protein-coding and ribosomal RNA genes could be inferred across the phyloge
217 d includes 13 protein-coding genes (PCGs), 2 ribosomal RNA genes, 22 transfer RNA genes and an 834 bp
219 enes such as that encoding the small subunit ribosomal RNA has revealed the extensive diversity of ba
220 ultiple genes impacting protein synthesis: a ribosomal RNA helicase gene, tRNA biosynthesis genes, an
221 mbled NPET, including an aberrantly flexible ribosomal RNA helix 74, resulting in at least three diff
222 and Nog1 work together in the maturation of ribosomal RNA helix 74, which is required to ensure prop
224 Here we used amplicon sequencing of the ribosomal RNA internal transcribed spacer region to exam
226 de resistance determinants including a novel ribosomal RNA methyltransferase situated in a CRISPR (cl
228 ent classes, enables identification of novel ribosomal RNA processing factors and sites, and suggests
231 spectroscopy for metabolic profiling and 16S ribosomal RNA sequencing to assess the gut microbiome.
233 esence of collagenolytic colonies and by 16S ribosomal RNA sequencing, which determined the anatomic
235 rs the integrity of the nucleolus, impairing ribosomal RNA synthesis and evoking the ribosomal protei
236 n the nucleoli is required for inhibition of ribosomal RNA synthesis and nucleolar segregation in res
237 ARF plays a significant role in regulating ribosomal RNA synthesis and processing, ribosome export
239 s were mostly identified on transfer RNA and ribosomal RNA until the last decade, when they have been
240 occus were assessed by DNA sequencing of 16S ribosomal RNA, and absolute S. aureus abundance was meas
241 e cells and in muscles of mice without NO66, ribosomal RNA, pre-rRNA, and protein synthesis all incre
246 the nascent chain and the negatively charged ribosomal-RNA lining the exit tunnel, and for quickly ej
247 olus, involves coordinated expression of pre-ribosomal RNAs (pre-rRNAs) and ribosomal proteins, pre-r
248 rial DNAs of two kinds: maxicircles encoding ribosomal RNAs (rRNAs) and proteins and minicircles bear
250 by auxiliary factors that process and modify ribosomal RNAs (rRNAs) or are involved in ribosome assem
251 f GLTSCR2 impairs maturation of 18S and 5.8S ribosomal RNAs (rRNAs), and Nop53 is required for matura
252 r certain non-coding RNAs (ncRNAs) including ribosomal RNAs (rRNAs), transfer RNAs (tRNAs), small nuc
255 were evaluated for their ability to inhibit ribosomal s6 kinase (RSK) activity and cancer cell proli
258 egulatory ribosomal binding and to defective ribosomal scanning of ORFs outside periods of productive
259 of a transmembrane domain upstream from the ribosomal slip site generates a force on the nascent pol
260 g site affects the long-term distribution of ribosomal species between 30S and 50S subunits versus 70
263 and RPLP2 (RPLP1/2), which form the ancient ribosomal stalk, were discovered decades ago but their f
264 d cryogenic electron microscopy to reveal 33 ribosomal states after the delivery of aminoacyl-tRNA by
268 s required for Mdn1 to transmit force to its ribosomal substrates, but it is not currently understood
269 the final maturation steps of the two large ribosomal subunit (50S) rRNAs, 23S and 5S pre-rRNAs, are
271 e of Staphylococcus aureus RsfS to the large ribosomal subunit and present a 3.2 angstrom resolution
272 S) that binds to uL14 protein onto the large ribosomal subunit and prevents its association with the
275 oximal tubule-specific expression of an L10a ribosomal subunit protein fused with enhanced green fluo
276 ysosomal ribosomal degradation and perturbed ribosomal subunit stoichiometry, both of which were resc
277 hich forms intersubunit bridges to the small ribosomal subunit, assumes different conformations in th
278 ial fast binding step of the IRES to the 40S ribosomal subunit, followed by a slow unimolecular react
279 evious work revealed that rps28bDelta (small ribosomal subunit-28B) mutants do not form PBs under nor
286 n partners identified 2 functional clusters: ribosomal subunits and nucleolar proteins including the
287 in the late stages of the biogenesis of 50S ribosomal subunits in plastids, a role that presumably e
288 20A-eGFP fusion proteins comigrated with 50S ribosomal subunits in Suc density gradients, even after
289 t mycobacterial HflX associates with the 50S ribosomal subunits in vivo and can dissociate purified 7
291 composition and structure of assembling 60S ribosomal subunits undergo numerous changes as pre-ribos
293 roduces a selective homeostatic reduction in ribosomal subunits, thereby offering a mechanism for the
298 ponse proteins included many associated with ribosomal synthesis and protein translation, suggesting
300 control (RQC) pathway stimulates regulatory ribosomal ubiquitylation (RRub) on distinct 40S ribosoma