ライフサイエンスコーパス: ribosyl

1 inobenzoic acid (pABA) and 5-phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) to produce 4-(beta-D-ribo

2 The large [2'-(3)H] KIEs indicate a ribosyl 2'-C-endo conformation at the transition states.

3 hanism in which a histidine deprotonates the ribosyl 2'-hydroxyl pinned in place by a serine, leading

4 e complex of the cyclase with an NAD analog, ribosyl-2'F-2'deoxynicotinamide adenine dinucleotide (ri

5 Disrupting the ribosyl 5'-hydroxyl interaction of transition state anal

6 -(3)H] KIE of 1.4% indicate that significant ribosyl 5'-reconfiguration and purine rotation occur on

7 dation pathway, resulting from action of ADP ribosyl-acceptor hydrolase (ARH) 3.

8 enzyme responsible for cADPR synthesis, ADP-ribosyl (ADPR) cyclase, is rapidly induced by ABA in bot

9 veal how these enzymes differentiate between ribosyl and deoxyribosyl nucleotides or nucleosides and

10 nate motion for NAMPT to be migration of the ribosyl anomeric carbon from the pyrophosphate leaving g

11 ribosyltransferases similar to CT and an ADP-ribosyl(arginine)protein hydrolase (ADPRH), which cleave

12 We previously reported that ADP-ribosyl-arginine is converted nonenzymatically to ornith

13 A damage, and increase the cellular poly(ADP-ribosyl)ate response.

14 t Drosophila insulator proteins are poly(ADP-ribosyl)ated and that mutation of the poly(ADP-ribose) p

15 efined its substrate specificity as mono(ADP-ribosyl)ated aspartate and glutamate but not lysine resi

16 urther, we demonstrated that LXR is poly(ADP-ribosyl)ated by PARP-1, a potential mechanism by which P

17 both subunits of the XPC-RAD23B are poly(ADP-ribosyl)ated by PARP1.

18 , our understanding of the roles of poly(ADP-ribosyl)ated Hrp38 on development is limited.

19 and preferentially associates with poly(ADP-ribosyl)ated PARP-1 in vitro and in vivo.

20 A joining in the presence of either poly(ADP-ribosyl)ated PARP-1 or poly(ADP-ribose).

21 38- to 87-kDa and the 17- to 38-kDa poly(ADP-ribosyl)ated protein expression increased by 74% and 275

22 ng elevated intracellular levels of poly(ADP-ribosyl)ated proteins (PAR(high)) responded to pharmacol

23 PARP is expressed in lens, and poly(ADP-ribosyl)ated proteins are primarily localized in the 38-

24 to hydrolyze ADP-ribose groups from mono(ADP-ribosyl)ated proteins.

25 Single or double deletion of the poly(ADP-ribosyl)ated regions and PARP inhibition increased the h

26 oisomerase I or by the formation of poly(ADP-ribosyl)ated topoisomerase I.

27 ere a significant amount of CTCF is poly(ADP-ribosyl)ated.

28 Tankyrase, which poly(ADP-ribosyl)ates and thereby destabilizes AXIN, also can pol

29 presence of DNA and NAD(+), PARP-1 poly(ADP-ribosyl)ates itself and Ku70/80 but not WRN, and gel-shi

30 Tankyrase1 poly(ADP-ribosyl)ates TRF1 in vitro, and its nuclear overexpressi

31 (Cat) subdomain responsible for the poly(ADP ribosyl)ating reaction.

32 report that HMGN1 affects the self-poly(ADP-ribosyl)ation (i.e., PARylation) of poly(ADP-ribose) pol

33 ankyrase 1 usually results in their poly(ADP-ribosyl)ation (PARsylation) and can lead to ubiquitylati

34 bitor) also prevented mitochondrial poly(ADP-ribosyl)ation (PARylation) and ROS formation.

35 Protein poly(ADP-ribosyl)ation (PARylation) has a role in diverse cellula

36 mic analyses uncover a new role for poly(ADP-ribosyl)ation (PARylation) in regulating the chromatin-a

37 PARP1 binds to and modifies PAP by poly(ADP-ribosyl)ation (PARylation) in vitro, which inhibits PAP

38 Poly(ADP-ribosyl)ation (PARylation) is a post-translational modif

39 Poly(ADP-ribosyl)ation (PARylation) is a post-translational prote

40 Poly(ADP-ribosyl)ation (PARylation) is a posttranslational modifi

41 Poly(ADP-ribosyl)ation (PARylation) is mainly catalysed by poly-A

42 polymerase 1 (PARP1) catalyzes the poly(ADP-ribosyl)ation (PARylation) of proteins, a posttranslatio

43 Poly(ADP-ribosyl)ation (PARylation) plays diverse roles in many m

44 ociated with an increase in protein poly(ADP-ribosyl)ation (PARylation), and was blocked by pharmacol

45 ranslational modifications, such as poly(ADP-ribosyl)ation (PARylation), regulate chromatin-modifying

46 s subject to negative regulation by poly(ADP-ribosyl)ation (PARylation).

47 ction occurs with or without PARP-1 poly(ADP-ribosyl)ation (PARylation).

48 Inhibition of TNKS1/2 poly(ADP-ribosyl)ation activity by JW55 led to stabilization of A

49 domain of WRN strongly inhibits the poly(ADP-ribosyl)ation activity in H2O2-treated control cell line

50 OGG1 stimulated the poly(ADP-ribosyl)ation activity of PARP-1, whereas decreased poly

51 hat couples DNA damage detection to poly(ADP-ribosyl)ation activity through a poorly understood mecha

52 function being involved both in the poly(ADP-ribosyl)ation and being a constituent of the NAD(+) salv

53 ectly binds activated PARP2 through poly(ADP-ribosyl)ation and can protect single-strand L1 integrati

54 odifies various nuclear proteins by poly(ADP-ribosyl)ation and functions as a key enzyme in the base

55 ctivity controls reversible protein poly(ADP-ribosyl)ation and potentially of how the defects in this

56 se of the AMP/ADP ratio during hyperpoly(ADP-ribosyl)ation and preserves mitochondrial coupling.

57 der hypoxic conditions, we detected poly(ADP-ribosyl)ation and reduced activity of GAPDH; inhibition

58 Moreover, RECQ1 regulates PARP1 auto-(ADP-ribosyl)ation and the choice between long-patch and sing

59 The process of poly(ADP-ribosyl)ation and the major enzyme that catalyses this r

60 Protein poly(ADP-ribosyl)ation and ubiquitination are two key post-transl

61 ty is required for PARP-1-dependent poly(ADP-ribosyl)ation at the promoters of commonly regulated tar

62 Suppression of DNA damage-induced poly(ADP-ribosyl)ation by PARP inhibitors impairs early DNA damag

63 In vitro, TIN2 protected TRF1 from poly(ADP-ribosyl)ation by tankyrase 1 without affecting tankyrase

64 hows that XPC-RAD23B is a target of poly(ADP-ribosyl)ation catalyzed by PARP1, which can be regarded

65 ore, our results suggest that Hrp38 poly(ADP-ribosyl)ation controls eye pattern formation via regulat

66 PARP-1 poly(ADP-ribosyl)ation correlated directly with induction of apop

67 Interestingly, p65 NF-kappaB poly(ADP-ribosyl)ation decreased its interaction with Crm1 in vit

68 We mapped the poly(ADP-ribosyl)ation domains and engineered MeCP2 mutation cons

69 Importantly, poly(ADP-ribosyl)ation facilitates intrachromosomal interactions

70 ytic domain and inhibit tankyrase's poly(ADP-ribosyl)ation function.

71 unohistochemistry revealed enhanced poly(ADP-ribosyl)ation in all experimental groups manifesting neu

72 view, we discuss recent findings on poly(ADP-ribosyl)ation in DNA damage response as well as the mole

73 viously, we hypothesized a role for poly(ADP-ribosyl)ation in plant defense responses when we detecte

74 The role of poly(ADP-ribosyl)ation in plant defenses was more extensively inv

75 and provided evidence for a role of poly(ADP ribosyl)ation in Stat-mediated transcriptional responses

76 c tissues, much less is known about poly(ADP-ribosyl)ation in the germline, where DNA double-strand b

77 Moreover, the rates of CD auto-poly(ADP-ribosyl)ation increased with second-order kinetics as a

78 Our data show that poly(ADP-ribosyl)ation inhibits Hrp38 binding to the Nanos 3' UTR

79 Poly(ADP-ribosyl)ation is a common post-translational modificatio

80 Poly(ADP-ribosyl)ation is a critical post-translational modificat

81 We conclude that poly(ADP-ribosyl)ation is a functional component in plant respons

82 Poly(ADP-ribosyl)ation is a posttranslational protein modificatio

83 Poly(ADP-ribosyl)ation is a reversible post-translational modific

84 Poly(ADP-ribosyl)ation is a reversible post-translational modific

85 Poly(ADP-ribosyl)ation is a reversible post-translational protein

86 Our results suggest that PARP-1 poly(ADP-ribosyl)ation is a terminal event in the apoptotic respo

87 In animals, poly(ADP-ribosyl)ation is associated with DNA damage responses an

88 The reversion of poly(ADP-ribosyl)ation is catalysed by poly(ADP-ribose) (PAR) gly

89 Poly(ADP-ribosyl)ation is catalyzed by a family of enzymes known

90 Poly(ADP-ribosyl)ation is involved in diabetes-induced renal over

91 Arsenite inhibition of poly(ADP-ribosyl)ation is one likely mechanism for the reported c

92 Recent studies suggest that poly(ADP-ribosyl)ation is one of the first steps of cellular DNA

93 Poly(ADP-ribosyl)ation is rapidly stimulated in cells after DNA d

94 results suggest that p65 NF-kappaB poly(ADP-ribosyl)ation may be a critical determinant for the inte

95 s, our results suggest that protein poly(ADP-ribosyl)ation may be a general mechanism to target prote

96 We find that poly(ADP-ribosyl)ation mediated primarily by poly(ADP-ribose) pol

97 We propose that poly(ADP-ribosyl)ation of chromatin-associated Parp1 serves as a

98 Interestingly, defective poly(ADP-ribosyl)ation of CTCF and dissociation from the molecula

99 vivo data support a model in which poly(ADP-ribosyl)ation of DDB2 suppresses DDB2 ubiquitylation and

100 d pathogen-dependent changes in the poly(ADP-ribosyl)ation of discrete proteins were also observed.

101 Here we show poly(ADP-ribosyl)ation of endogenous MeCP2 in mouse brain tissue.

102 onclusion, these data indicate that poly(ADP-ribosyl)ation of GAPDH and the subsequent inhibition of

103 on was found to be a consequence of poly(ADP-ribosyl)ation of GAPDH by poly(ADP-ribose) polymerase (P

104 Elevated glucose increased poly(ADP-ribosyl)ation of GAPDH in WT aortae, but not in the aort

105 The biological functions of poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoprotein

106 Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoprotein

107 ors of PARP-1 auto-modification and poly(ADP-ribosyl)ation of histone H1 in the absence of free DNA e

108 However, poly(ADP-ribosyl)ation of K566 in CP190 promotes protein-protein

109 , and gel-shift assays showed that poly-(ADP-ribosyl)ation of Ku70/80 decreases the DNA-binding affin

110 Significantly, (ADP-ribosyl)ation of Ku70/80 reduces the ability of this fac

111 Numerous bacterial toxins catalyze mono(ADP-ribosyl)ation of mammalian proteins to influence cell ph

112 (PARP-1) can be hyperactivated, causing (ADP-ribosyl)ation of nuclear proteins (including itself), re

113 1 itself becomes activated, but the poly(ADP-ribosyl)ation of other cellular proteins is severely imp

114 B sites and showed that TNF induced poly(ADP-ribosyl)ation of RelA when bound to the Phex promoter.

115 nds to DNA breaks and catalyzes the poly(ADP-ribosyl)ation of several substrates involved in DNA dama

116 that Parg null mutation does cause poly(ADP-ribosyl)ation of Squid and hrp38 protein, as well as the

117 ollowing that, we demonstrated that poly(ADP-ribosyl)ation of Squid and hrp38 proteins inhibits splic

118 ing to nicked DNA, PARP-1 catalyzes poly(ADP-ribosyl)ation of the acceptor proteins and itself using

119 ing to nicked DNA, PARP-1 catalyzes poly(ADP-ribosyl)ation of the acceptor proteins using NAD (+) as

120 proximal tubules after IRI leads to poly(ADP-ribosyl)ation of the key glycolytic enzyme glyceraldehyd

121 Phosphorylation, acetylation, or poly(ADP-ribosyl)ation of the linker residues may therefore act a

122 The poly(ADP-ribosyl)ation of three of these yeast proteins, together

123 RP-1 action) or by the formation of poly(ADP-ribosyl)ation of topoisomerase I (PARP-1/NAD action).

124 Poly(ADP-ribosyl)ation of topoisomerase I by PARP-1 in the presen

125 Poly(ADP-ribosyl)ation of transcription factors and coregulators,

126 g factor 2 (TRF2) and is capable of poly(ADP-ribosyl)ation of TRF2, which affects binding of TRF2 to

127 e demonstrate that DDB2 facilitated poly(ADP-ribosyl)ation of UV-damaged chromatin through the activi

128 Poly(ADP-ribosyl)ation of various nuclear proteins catalyzed by a

129 Poly(ADP-ribosyl)ation often involves the addition of long chains

130 RP-interacting protein that removes mono(ADP-ribosyl)ation on glutamate amino acid residues in PARP-m

131 that WS cells are deficient in the poly(ADP-ribosyl)ation pathway after they are treated with the DN

132 Poly(ADP-ribosyl)ation plays a major role in DNA repair, where it

133 ed on the signaling role of PARP in poly(ADP-ribosyl)ation rather than any role that can be ascribed

134 ational modification of proteins by poly(ADP-ribosyl)ation regulates many cellular pathways that are

135 gether, these findings suggest that poly(ADP-ribosyl)ation regulates the interaction between hnRNPs a

136 sses Nanos translation, whereas its poly(ADP-ribosyl)ation relieves the repression effect, allowing r

137 WRN by PARP-1 was influenced by the poly(ADP-ribosyl)ation state of PARP-1.

138 the suppression of topoisomerase I poly(ADP-ribosyl)ation through the competition with NAD for the b

139 crease in activity of GAPDH and its poly(ADP-ribosyl)ation were prevented by overexpression of either

140 tion), or nucleotides (for example, poly(ADP-ribosyl)ation).

141 In response to DNA damage, poly(ADP-ribosyl)ation, a unique post-translational modification,

142 ction, which caused increased Hrp38 poly(ADP-ribosyl)ation, also resulted in the rough-eye phenotype

143 gh aberrant crosstalk between CTCF, poly(ADP-ribosyl)ation, and DNA methylation may be a general mech

144 Poly(ADP-ribosyl)ation, attaching the ADP-ribose polymer chain to

145 ilization is largely independent of poly(ADP-ribosyl)ation, it cannot solely explain the chromatin re

146 onally, DDB2 itself was targeted by poly(ADP-ribosyl)ation, resulting in increased protein stability

147 We hypothesize that poly (ADP-ribosyl)ation, that is, poly (ADP-ribose) polymerase (PA

148 idly modified by tankyrase-mediated poly(ADP-ribosyl)ation, which promotes the proteolysis of Axin an

149 eta-catenin signaling by preventing poly(ADP-ribosyl)ation-dependent AXIN degradation, thereby promot

150 efense-associated expression of the poly(ADP-ribosyl)ation-related genes PARG2 and NUDT7 and observed

151 e of the genome may be modulated by poly(ADP-ribosyl)ation.

152 e 1 (PARP1) and stimulates its auto-poly(ADP-ribosyl)ation.

153 ibose glycosidic bond formed during poly(ADP-ribosyl)ation.

154 cellular processes are regulated by poly(ADP-ribosyl)ation.

155 to the sites of DNA-damage-induced poly(ADP-ribosyl)ation.

156 E988Q mutant, which only catalyzes mono(ADP-ribosyl)ation.

157 lso required for post-translational poly(ADP-ribosyl)ation.

158 ity regulates the extent of in vivo poly(ADP-ribosyl)ation.

159 onsumed in lysine deacetylation and poly(ADP-ribosyl)ation.

160 spartate residues in the process of poly(ADP-ribosyl)ation.

161 tion are similar to the kinetics of poly(ADP-ribosyl)ation.

162 but its function can be modified by poly(ADP-ribosyl)ation.

163 magnesium salt present did they generate the ribosyl cation by binding to the leaving group and then

164 used to probe the mechanism of nicotinamide-ribosyl cleavage and acetyl group transfer.

165 We demonstrate that nicotinamide-ribosyl cleavage is distinct from acetyl group transfer

166 pports a mechanism where, after nicotinamide-ribosyl cleavage, the carbonyl oxygen of acetylated subs

167 on involves the cleavage of the nicotinamide-ribosyl, cleavage of an amide bond, and transfer of the

168 artial 3'-OH polarization and H3'-endo-->exo ribosyl configuration at the spMTAN transition state.

169 eotides at sGC alpha1beta1 require a 3'-endo ribosyl conformation (versus 3'-exo in 3'-MANT-2'-dATP).

170 Mammalian CD38 and its Aplysia homolog, ADP-ribosyl cyclase (cyclase), are two prominent enzymes tha

171 zed by multifunctional enzymes, CD38 and ADP-ribosyl cyclase (cyclase).

172 r molecular inhibition of CD38 abolished ADP-ribosyl cyclase activity and disrupted elongation of the

173 show that CD38 expression and endogenous ADP-ribosyl cyclase activity are developmentally regulated d

174 a glucocorticoid, on CD38 expression and ADP-ribosyl cyclase activity in HASM cells stimulated with T

175 is a multifunctional protein possessing ADP-ribosyl cyclase activity responsible for both the synthe

176 time PCR, and Western blot analysis, and ADP-ribosyl cyclase activity was assayed with nicotinamide g

177 TNF-alpha augmented CD38 expression and ADP-ribosyl cyclase activity, which were attenuated by dexam

178 is of beta-NAD(+), but also carrying out ADP-ribosyl cyclase and ADP-ribosyltransferase activities, m

179 ydrolytic activity and lacked detectable ADP-ribosyl cyclase and ADP-ribosyltransferase activities.

180 sis of a BFA-ADP-ribose conjugate by the ADP-ribosyl cyclase CD38 and (ii) covalent binding of the BF

181 ibitors of cADPR hydrolysis by the human ADP-ribosyl cyclase CD38 catalytic domain (shCD38), illustra

182 ous assay with sirtuin-1 (Sirt1) and the ADP-ribosyl cyclase CD38, the resulting steady-state kinetic

183 CD38 belongs to the ADP-ribosyl cyclase family and possesses both ectoenzyme and

184 CD38, which belongs to the ADP-ribosyl cyclase family, catalyzes synthesis of both NAAD

185 family of related enzymes, including the ADP-ribosyl cyclase from Aplysia california (ADPRAC) and CD3

186 SAN4825, an ADP-ribosyl cyclase inhibitor that reduces cADPR and NAADP s

187 enzymatically using Aplysia californica ADP-ribosyl cyclase or mammalian NAD glycohydrolase.

188 Aplysia californica ADP-ribosyl cyclase tolerates even the bulky 8-phenyl-nicoti

189 te properties toward Aplysia californica ADP-ribosyl cyclase were investigated.

190 sly reported that cADPR, produced by the ADP-ribosyl cyclase, CD38, controls calcium influx and chemo

191 PR), which is generated by an ectoenzyme ADP-ribosyl cyclase, CD38.

192 enzymatically using Aplysia californica ADP-ribosyl cyclase.

193 second messenger synthesized from NAD by ADP-ribosyl cyclases (ADPR cyclases).

194 y, a family of ectocellular enzymes, the ADP-ribosyl cyclases (ARCs), has emerged as being able to ch

195 substrate: poly(ADP-ribose) polymerases, ADP-ribosyl cyclases (CD38 and CD157), and sirtuins (SIRT1-7

196 ADP-ribosyl cyclases are structurally conserved enzymes that

197 metabolites of NADH, such as N-methyl- and N-ribosyl-dihydronicotinamide.

198 a-linked nucleotide N(1) -(5-phospho-alpha-D-ribosyl)-DMB (alpha-ribazole-5'-P, alpha-RP), a precurso

199 One of these, Rv0060 (DNA ADP-ribosyl glycohydrolase, DarG(Mtb) ), functions along wit

200 Elongation of the linker between the ribosyl group and the MANT group and substitution of N-a

201 Using the ADP-ribosyl group as a distinct marker, we observe conformat

202 F159 covers the top (beta) surface of the ribosyl group at the catalytic site.

203 in GdAGA by the presence of a more flexible ribosyl group at the deoxyadenosine site.

204 he enzyme and a conformational change in the ribosyl group leading to migration of the anomeric carbo

205 s with oxacarbenium mimics replacing the NMN-ribosyl group of NAD(+) show 200-620-fold increased affi

206 gresses, carbocation character builds on the ribosyl group, the distance between the purine and the c

207 nd BcmB that prefer substrates containing 2'-ribosyl groups have a phenylalanine positioned in the ac

208 ansferase (ART-2)-mediated attachment of ADP-ribosyl groups to cell surface proteins; expression of A

209 rase, the enzyme that uses NAD to attach ADP-ribosyl groups to cell surfaces, are also resistant to C

210 ce ART-2 uses NAD but not ADPR to attach ADP-ribosyl groups to the cell surface, and that these group

211 thine and that ADP-ribosylated HNP-1 and ADP-ribosyl-HNP-(ornithine) were isolated from bronchoalveol

212 On incubation of di- or mono-ADP-ribosyl-HNP-1 at 37 degrees C, ADP-ribosylarginine was p

213 The finding of ADP-ribosyl-HNP-1 in BALF but not in leukocyte granules sugg

214 BALF from an IPF patient contained ADP-ribosyl-HNP-ornithine as well as mono- and di-ADP-ribosy

215 Therefore, nsP3 mono(ADP-ribosyl)hydrolase activity is critical for CHIKV replica

216 proteins, these toxins also act as NAD(+)-N-ribosyl hydrolases.

217 t the increasingly compelling view that (ADP-ribosyl)hydrolases are a vital element within ADP-ribosy

218 n overview of the different families of (ADP-ribosyl)hydrolases.

219 inding of DNA, although the presence of a 3'-ribosyl hydroxyl group partially overcame this requireme

220 ormed to study the effect of polarization of ribosyl hydroxyls, torsional angles, and the effect of b

221 attacks NAD(+) to form an RNA-2'-phospho-ADP-ribosyl intermediate that undergoes transesterification

222 The ADP-ribosyl is removed by the dinitrogenase reductase-activa

223 bstrates to form S-methyl-5-thioribose and S-ribosyl-l-homocysteine.

224 he difficulty of generating the sensitive N1-ribosyl link.

225 in-H and DADMe-Immucillin-H synthesized with ribosyl mimics of l-stereochemistry.

226 (N-methyl)anthraniloyl substitutions at the ribosyl moiety and compared the data with that for the s

227 otic with a C-glycosidic linkage between the ribosyl moiety and the pyrazolopyrimidine base.

228 methylated on the 2'-O-hydroxyl site of the ribosyl moiety at position 34 (Um34).

229 pectively, which catalyze the removal of the ribosyl moiety from nucleosides so that the nucleotide b

230 recedented transfer and isomerization of the ribosyl moiety of S-adenosylmethionine (AdoMet) to a mod

231 )2-like transition-state model, in which the ribosyl moiety possesses significant bond order to both

232 8-Chloroadenosine (8-Cl-Ado) is a ribosyl nucleoside analog currently in phase I testing f

233 8-Aminoadenosine (8-NH(2)-Ado), a ribosyl nucleoside analog, in preclinical models of mult

234 es in hPNP cause this stack, centered on the ribosyl O-4' oxygen, to squeeze together and push electr

235 ects predicted a 3-endo conformation for the ribosyl oxacarbenium-ion corresponding to H1'-C1'-C2'-H2

236 y Asp85, interacts with the O2 of T4 and O4' ribosyl oxygens of A23 and T4.

237 We used these findings to develop a novel ribosyl phosphate-modified derivative of c-di-GMP contai

238 Combined deficiencies of poly(ADP)ribosyl polymerase 1 (PARP1) and ataxia telangiectasia m

239 ase in Bcl2-like protein 4, cleaved Poly ADP-Ribosyl Polymerase 1 and cleaved Caspase 3 levels with a

240 -regulated iNOS, nitrotyrosine, and poly-ADP-ribosyl polymerase expression and inhibited CAR-induced

241 peroxynitrite-poly-adenosine 5'-diphosphate ribosyl polymerase pathway contributes to the cellular i

242 ble nitric oxide synthase (iNOS) or poly(ADP-ribosyl) polymerase (PARP1) in only their marrow-derived

243 rtners from DNA ligase IIIalpha and poly(ADP-ribosyl) polymerase 1.

244 y an H. pylori toxin, the intrinsic poly(ADP-ribosyl) polymerase activity of PARP-1 is activated by a

245 These interventions also increased poly(ADP-ribosyl) polymerase and sirtuin activity, suggesting an

246 Here, we show that tankyrase, a poly(ADP-ribosyl) polymerase that regulates beta-catenin levels,

247 es place CoaSt6 in a superfamily of poly(ADP-ribosyl)polymerase (PARP)-like proteins.

248 bases and fluorescent groups at the 2',3'-O-ribosyl position.

249 rs) that recognize specific parts of the ADP-ribosyl posttranslational modification, and is removed b

250 es to form purine and alpha-D-phosphorylated ribosyl products.

251 on, and further evidence suggests a role for ribosyl pseudorotation.

252 ith varied C1'-N9, C1'-Ophosphate distances, ribosyl pucker configurations and N7-protonation states.

253 nsition states are characterized by C2'-endo ribosyl pucker, based on the beta-secondary [2'-(3)H] KI

254 Derivatives of ribosyl pyrophosphate have been synthesized, and examine

255 F159W-Leuko-PNP) as a reporter group for the ribosyl region of the catalytic site.

256 ; anti-Hib capsular polysaccharide IgG, poly-ribosyl-ribitol-phosphate (PRP), IgG subclass, and cellu

257 (C1'-Ophosphate distance = 2.26 A), 2'-C-exo-ribosyl ring pucker and the O5'-C5'-C4'-O4' dihedral ang

258 tion by the substrate phosphodianion and the ribosyl ring, respectively, and an 8.6 kcal/mol stabiliz

259 yl)hydrolases are a vital element within ADP-ribosyl signaling pathways and they hold the potential f

260 nding to the pyrimidine base, sulfate, and a ribosyl species, which can be modeled as a glycal.

261 a three-site mAC pharmacophore; the 2',3'-O-ribosyl substituent and the polyphosphate chain have the

262 bases, revealing an unprecedented effect of ribosyl substitution on electronic energy relaxation.

263 , is not a substrate for tankyrase1 poly(ADP-ribosyl)sylation in vitro.

264 nuclear enzyme poly-adenosine 5'-diphosphate ribosyl synthetase, and eventual severe energy depletion

265 A nucleoside queuosine (Q), an unprecedented ribosyl transfer from the cofactor S-adenosylmethionine

266 eptidylimidate, whereas the mechanism of ADP-ribosyl transfer to proteins is undetermined.

267 teins and in some cases catalyze protein ADP-ribosyl transfer.

268 robe for mechanisms of sirtuin-catalyzed ADP-ribosyl transfer.

269 It was shown in system (b) that oligo(ADP-ribosyl) transfer to histone H(1) is 1% of that of auto(

270 to significantly lower adenosine diphosphate ribosyl transferase (ADPRT)/PARP-1 activities in respons

271 either the receptor binding (CRM107) or ADP-ribosyl transferase (CRM197) activities do not inhibit t

272 osyl transferases, including human adenosine ribosyl transferase 5 (ART5) and Cholera toxin subunit A

273 tively, these data indicate that AvrRpm1 ADP-ribosyl transferase activity contributes to virulence by

274 The ADP-ribosyl transferase domain inhibits late steps of cytoki

275 fies the catalytic glutamate in the mono-ADP ribosyl transferase domain of the SdeA, thus blocking th

276 tivating protein domain and a C-terminal ADP-ribosyl transferase domain.

277 chitecture with two active subunits, the ADP ribosyl transferase PltA and the DNase CdtB, linked to a

278 d increased affinity in the hydrolytic and N-ribosyl transferase reactions catalyzed by CTA.

279 stabilization, but DTA and PTA catalyze ADP-ribosyl transferase reactions more from ground-state des

280 Inhibition of the NAD(+) hydrolysis and ADP-ribosyl transferase reactions of DTA gave K(i) values fr

281 The NAD+-dependent deacetylase and mono-ADP-ribosyl transferase SIRT6 stabilizes the genome by promo

282 PARP-3 is a member of the ADP-ribosyl transferase superfamily of unknown function.

283 PARP3 is a member of the ADP-ribosyl transferase superfamily that we show accelerates

284 /NtrC, and DRAT (dinitrogenase reductase ADP-ribosyl transferase)-DRAG (dinitrogenase reductase-activ

285 along with its cognate toxin Rv0059 (DNA ADP-ribosyl transferase, DarT(Mtb) ), to mediate reversible

286 odeling indicated that AvrRpm1 may be an ADP-ribosyl transferase.

287 rifampin and harbored arr-3, a rifampin ADP-ribosyl transferase.

288 of a nucleophilic transition state for an N-ribosyl transferase.

289 ored arr-3, a rifampin adenosine diphosphate-ribosyl transferase.

290 f PARP-1 occur independently of its poly(ADP-ribosyl) transferase activity.

291 s a catalytic domain with mammalian mono(ADP-ribosyl)transferase activity.

292 transition states previously reported for N-ribosyl transferases and is the first demonstration of a

293 ed PARP12, a member of a large family of ADP-ribosyl transferases, as an interferon-induced gene (ISG

294 N(tz)AD(+) also serves as a substrate for ribosyl transferases, including human adenosine ribosyl

295 d of science in motion-the field of poly(ADP-ribosyl) transferases (PARPs) and ADP-ribosylation.

296 unctions of intracellular mammalian mono(ADP-ribosyl)transferases, such as any ability to regulate Ab

297 ransfers (UDP-glucose), and electron and ADP-ribosyl transfers (NAD(P)H/NAD(P)(+)) to drive metabolic

298 at 2.7A and with product PR-ATP at 2.9A (the ribosyl-triphosphate could not be resolved).

299 The terminal ribosyl unit at one end of the intermediate formed a clo

300 cts predicted a 3'-endo conformation for the ribosyl zwitterion, corresponding to a H1'-C1'-C2'-H2' t