ライフサイエンスコーパス: rigidity

1 ), and an RMSD score (which measures overall rigidity).

2 e range of canopy morphology, densities, and rigidity.

3 xt], determines the onset of prestresses and rigidity.

4 rongest changes at the F4 site toward higher rigidity.

5 the cell periphery, to maintain polarity and rigidity.

6 MMPs degrade ECM proteins to reduce external rigidity.

7 to cortical instability, and decreased cell rigidity.

8 dification state and chromatin-based nuclear rigidity.

9 dification state and chromatin-based nuclear rigidity.

10 lacking "induced-fit", reflecting structural rigidity.

11 ignificant influence on the membrane bending rigidity.

12 bonding, bidentate tethering, and structural rigidity.

13 mor, slowing of movement (bradykinesia), and rigidity.

14 ably tune burst magnitude by altering linker rigidity.

15 uely high surface area, internal volume, and rigidity.

16 d morphology via its contribution to nuclear rigidity.

17 adaptation outweighs the cost of functional rigidity.

18 limits the cell migration more than the ECM rigidity.

19 ypokinetic score, combining bradykinesia and rigidity.

20 hoic acids and increases bacterial cell wall rigidity.

21 comprised of heterogeneous distributions of rigidity.

22 integral proteins into domains of different rigidity.

23 iffering significantly depending on scaffold rigidity.

24 ulation of HA levels independently of matrix rigidity.

25 flexibility, whereas detyrosination imparts rigidity.

26 fferences attributable to microstructure and rigidity.

27 logy of kirigami to achieve connectivity and rigidity.

28 use of clouded corneas and increased corneal rigidity.

29 en cellular tension and extracellular matrix rigidity.

30 and trabecular bone structure, density, and rigidity.

31 ibit virus-cell fusion by promoting membrane rigidity.

32 to an effective increase of the liquid shear rigidity.

33 n, and wound healing are regulated by tissue rigidity.

34 al properties of the cytoskeleton and matrix rigidity.

35 ne leafs to display a heterogeneity in splay rigidities.

36 al processes in cell adhesion, motility, and rigidity adaptation are regulated by integrin-mediated a

37 n process by increasing the bilayer membrane rigidity against the dehydration tension and decreasing

38 solid tumors tend to have higher mechanical rigidity, allowing them to aggressively invade and sprea

39 h suspected meningitis (eg, headache, nuchal rigidity, altered mental status) were screened consecuti

40 Microcomputed tomography and CT-based rigidity analyses were performed to assess cortical and

41 y capture the filament bending and torsional rigidities and intersubunit torsional flexibility measur

42 Significant clusters for suppression of rigidity and akinesia, as well as for overall motor impr

43 r of RacE caused massive defects in cortical rigidity and architecture as assessed by aspiration assa

44 anglia-thalamic circuits are associated with rigidity and bradykinesia in patients with Parkinson's d

45 The key clinical features of PD, rigidity and bradykinesia, result from neurotransmitter

46 Consequently, the rigidity and bulky form factor of the existing devices a

47 -kappaB expression, whereas increased tissue rigidity and cell motility/contractility help mediate tu

48 provides broadly applicable insight into the rigidity and compression of hybrid materials.

49 aced by a fused aromatic ring to enhance the rigidity and conjugation of the dye moieties.

50 A statistical approach to the control of rigidity and connectivity in kirigami with random cuts c

51 vides a general framework for the control of rigidity and connectivity in planar kirigami.

52 through experiments and simulations that the rigidity and connectivity of filaments in active biopoly

53 inks) that still allow us to preserve global rigidity and connectivity of the kirigami.

54 ws that the combination of the marginal band rigidity and cortical tension increases the ability of t

55 stems from the balance between marginal band rigidity and cortical tension.

56 ribe that D00-D0 exhibits a higher degree of rigidity and D00 likely functions as a juncture domain a

57 m of scarring that increases muscular tissue rigidity and decreases cardiac contractility.

58 This shows that both conformational rigidity and dynamics are essential for controlling prot

59 This connection between rigidity and dynamics at different timescales is likely

60 rm allows for independent tuning of actuator rigidity and elasticity over broad ranges without changi

61 ties of tethered actin bundles such as their rigidity and filament density.

62 Finally, a combination of increased coat rigidity and force from actin polymerization enables rob

63 Myoclonus, rigidity and hallucinations were more frequent in patien

64 These processes diminish tissue rigidity and help cells to overcome the energy barrier t

65 d framework, affected by the introduction of rigidity and in the presence of external stimuli (temper

66 ecule under tension, contour length, bending rigidity and intrinsic stiffness decreased in hypermethy

67 c tissue remodeling, with ensuing esophageal rigidity and loss of luminal diameter caused by strictur

68 rying two distinct parameters, environmental rigidity and motor protein activities, we observe that t

69 ents with progressive encephalomyelitis with rigidity and myoclonus or stiff person syndrome, and gly

70 ents with progressive encephalomyelitis with rigidity and myoclonus, and less frequently in other var

71 r the organic cations to tune the structural rigidity and octahedral distortion yields a record excit

72 Due to their high flexural rigidity and persistence length of the order of a few mi

73 he tug-of-war between evolutionary forces of rigidity and plasticity over transcriptional regulatory

74 is approximately 60% fat; it therefore lacks rigidity and poses structural preservation challenges du

75 ility, most likely by introducing structural rigidity and promoting receptor self-association within

76 taAAs should be valuable tools for bestowing rigidity and proteolytic stability on bioactive peptides

77 The rigidity and relatively primitive modes of operation of

78 a model of frameshifting based on structural rigidity and resistance to mechanical unfolding, and ins

79 al modeling efforts have focused on bundles' rigidity and shape.

80 preading response as a function of substrate rigidity and show that remarkably, depending on the surf

81 uilibrated covalent chemical linkages impart rigidity and stability to the films examined in macrosco

82 to the outer membrane to establish membrane rigidity and stability.

83 on the viral surface, thus increasing capsid rigidity and stability.

84 dge adjacent 5-fold axes, thus aiding capsid rigidity and stability.

85 rent behavior from alkanethiols, with higher rigidity and stronger intermolecular interactions, they

86 ondary plant cell walls, contributing to its rigidity and structural integrity in vascular plants.

87 The conformational rigidity and the enriched stability of these novel 16pai

88 rganizational specialization, organizational rigidity and the locus of innovation.

89 from the brain which strongly depends on the rigidity and the permeability of the brain tissue.

90 abels, EC and ECm, both of which possess the rigidity and the reduction resistance needed for extract

91 T-induced alteration of the Gaussian bending rigidity and their crowding in concert with the transmem

92 s a promising approach to strengthen scleral rigidity and thus to inhibit eye growth in progressive m

93 rnal physical environment, such as substrate rigidity and topography, and internal physical states, s

94 in C. albicans, involving increased membrane rigidity and TOR signaling.

95 (higher conformational flexibility and lower rigidity) and greater water holding ability was founded

96 ding affinity correlated with conformational rigidity, and a hybridization preference for sp(2) > S-

97 ied with both detachment technique and plant rigidity, and deeper hooks enabled faster prey extractio

98 ombination of low dimensionality, structural rigidity, and distinct interior and exterior microenviro

99 he changes in protein concentration, monomer rigidity, and environmental conditions.

100 histone modification state dictates nuclear rigidity, and modulating it is sufficient to both induce

101 ditional motor features (postural imbalance, rigidity, and postural abnormalities) and increasingly r

102 ergistic balance between the flexibility and rigidity, and the unique molecular recognition for silic

103 ons, such as bradykinesia (slowed movement), rigidity, and tremors.

104 d membranes, its effects on membrane bending rigidity are assumed to be nonuniversal; i.e., cholester

105 o these physical cues, such as stiffness and rigidity, are important determinants of cell differentia

106 m-Tpm overlap binding strength or mechanical rigidity as is often assumed.

107 m that naturally captures the characteristic rigidity associated with delusional beliefs.

108 haracterised by an increased stiffness, with rigidity associated with disease progression.

109 that spatial variations in membrane bending rigidity associated with lipid domains embedded within t

110 hereas its axial skeleton displays incipient rigidity at the base of the tail with a flexible lumbar

111 ies and found that a prevalence of high loop rigidity at the binding interface is an indicator of inc

112 h a range of Young's modulus values for bulk rigidity, at the subcellular level, tissues are comprise

113 des elastic hydrogels with higher mechanical rigidity, better bio-adhesion and longer residence time

114 focused on improvement in motor (eg, tremor, rigidity, bradykinesia) and nonmotor (eg, constipation,

115 ed rod, we performed a second measure of its rigidity by deflecting it with a uniform magnetic field.

116 Cells responded to substrate rigidity by reorganizing the distribution and size of hi

117 eir conformations, e.g., by imposing greater rigidity, by subtly altering certain side chain vectors,

118 nanomembranes with thinning-reduced flexural rigidities can be shaped into various 3D mesostructures,

119 Field's metal, Pb-based solder), mechanical rigidity can be actively tuned with external heating or

120 ible macrocyclic peptides, and that scaffold rigidity can be used to tune optimal lipophilicity.

121 ed hydrophilic domain to circumvent membrane rigidity caused by defective palmitoylation turnover.

122 gaps, improved oscillator strengths and core rigidity compared to previously reported structures, per

123 y, yet insufficient stability and mechanical rigidity, compared to polyamide-based molecules, limit t

124 ations (S311A and P312L) determined that the rigidity conferred by prolines in ECL3 are essential for

125 and variations in substrate positioning and rigidity, confirming previous kinetic and theoretical pr

126 The gradual increase in rigidity correlates with an increase in lipid binding af

127 suggesting that a general loss in structural rigidity correlates with gains in TRX sensitivity during

128 The reduced corneal rigidity could result in underestimating IOP in patients

129 cally investigated the influence of membrane rigidity, curvature induced by the protein coat, area co

130 atic type, are considered to demonstrate the rigidity dependent adhesion properties.

131 approach by which we reveal an environmental rigidity-dependent intracellular stiffness that increase

132 Cells adopted a rigidity-dependent phenotype whereby the actin cytoskele

133 ter associating with nascent adhesions under rigidity-dependent tension downstream of SFK activity.

134 ntractile force, nuclear elasticity, and ECM rigidity-determine the effectiveness of cell migration t

135 tering ligand density, we show that fibrotic rigidities downregulate MMP-9 expression and secretion,

136 hindered by poor cyclability and mechanical rigidity due to the lack of a flexible and durable catal

137 originates from a cooperation of structural rigidity, dynamics at different timescales, and alloster

138 gate the rules underlying genome fluidity or rigidity, e.g., by comparing marker distances and marker

139 After centuries of striving for structural rigidity, engineers and scientists alike are increasingl

140 d as a function of both feature diameter and rigidity, establishing the groundwork for a new generati

141 The degree of stereochemical rigidity exhibited by the dioxo compound, as established

142 is especially desired in medical devices as rigidity facilitates the implantation process, while fle

143 interface, unsatisfied hydrogen bonds, and a rigidity factor).

144 frequencies to ensure the film flatness and rigidity for collecting meaningful data.

145 but also a high dynamic range and increasing rigidity from the N to C terminus.

146 alcium signaling was unaffected by substrate rigidity, implying that early steps in T cell receptor t

147 Cognitive rigidity imposed by neural circuit adaptations during ni

148 used to reveal that IFITM3 promotes membrane rigidity in a glycine-95-dependent and amphipathic helix

149 disrupted prefrontal function and cognitive rigidity in AN patients.

150 been manifested from this study that loss of rigidity in bilayer breaks down the strong hydrogen bond

151 Further, we found high conformational rigidity in CAP 3 that confers maximum perturbations in

152 The discovery of this extreme rigidity in combination with high charge density gives i

153 xperimental observations of unexpected shear rigidity in confined liquids, on very low frequency scal

154 o have a minimal amount of effective angular rigidity in order for cells to perform the various class

155 This apparent rigidity in the thermal thresholds of even stress-resist

156 photosynthetic process is tied to thylakoid rigidity in this type of cyanobacterial cell.

157 a general hallmark of geometrically induced rigidity in underconstrained materials and could be used

158 understand geometric-incompatibility-induced rigidity in underconstrained materials, including subiso

159 revail in conflict are high levels of "moral rigidity" in their tribal members, that is, of inflexibl

160 es, such as membrane undulations and bending rigidity, in a PIP2-dependent manner.

161 in motors and cross-linking proteins and the rigidity, initial orientation, and turnover of actin fil

162 ion of nature's learnings to build intrinsic rigidity into the design of clinical candidates.

163 ctive gel suggests that adaptation to matrix rigidity is controlled by internal mechanical properties

164 Moreover, scaffold rigidity is essential for robust B-cell triggering.

165 Finally, an increased membrane rigidity is found to result in poor merozoite alignment,

166 This rigidity is key to rationalizing the protection toward a

167 The tissue rigidity is not expected to relate to G(s), and indeed o

168 cal constants such as the moduli for bending rigidity (kappa(C)) and area compressibility (K(A)).

169 ive tissue extracellular matrix suggests the rigidity laid down for conversion persists.

170 durotaxis, mechanical stimulation by matrix rigidity leads to directed migration.

171 tes and controlled environments with defined rigidities limit the range of cell behavior and influenc

172 age of sheathed flagella bundles is the high rigidity, making high swimming speeds possible.

173 ed K14.ROCK(er)-mediated (p-Mypt1/tenascin C/rigidity) malignant conversion.

174 evidence that parkinsonian bradykinesia and rigidity may arise from an oversynchronization of affere

175 ion and moral objectivism, I show how "moral rigidity" may have evolved through partner selection mec

176 id group to the bulky Mn complex ensures the rigidity needed for high enantioselectivity and dictates

177 We also varied the rigidities of the tissues.

178 al liquid crystalline membranes with bending rigidity of a few kT exhibit unusual properties and they

179 i and are required to maintain the shape and rigidity of apicomplexan zoites.

180 We also measure the curvature rigidity of asymmetric bilayers and find that a sufficie

181 taf/DeltaD) proved as good indicators of the rigidity of cell attachment.

182 3) Changes in the relative rigidity of cell-wall chitin were associated with aberra

183 A origami in conjunction with the structural rigidity of colloidal particles, we demonstrate the para

184 n developed yet because of the bulkiness and rigidity of conventional imaging modules and their compo

185 Here the rigidity of cross-linked collagen synergizes with retino

186 at cholesterol locally increases the bending rigidity of DOPC membranes, similar to saturated membran

187 that DAP substitution increases the flexural rigidity of dsDNA yet also facilitates conformational sh

188 The rigidity of elastic networks is characterized by a topol

189 e-beam exposure can significantly alter the rigidity of elastomeric poly(dimethylsiloxane) substrate

190 These results implied that diminish rigidity of enzyme might disturb the catalytic conformat

191 rulence is closely linked to the increase in rigidity of infected erythrocytes and their adhesion to

192 ion step can be attributed to the structural rigidity of its immediate precursor.

193 aches, including enhancing lipophilicity and rigidity of new inhibitors and modulating the p K(a) of

194 levels of lamin A are known to increase the rigidity of nuclei, inevitably disrupting contractile ac

195 The rigidity of numerous biological filaments and crafted mi

196 rystals whereas thermal history affected the rigidity of oleogel samples.

197 tested bacterial strains, whilst high local rigidity of peptides within ripened cheese soluble fract

198 A dependency, indicating that the structural rigidity of proline might contribute to the requirement

199 affinity, as well as the dimensionality and rigidity of scaffold presentation on B-cell activation r

200 High rigidity of substrates allowed axially controlled synthe

201 cm(3)/mol, respectively, indicating a higher rigidity of Tg.

202 The rigidity of the backbone yields a sharp longest waveleng

203 ridinium), the aromatic spacers increase the rigidity of the cation, reduce the interlayer spacing, a

204 evels of p27 were associated with plasticity/rigidity of the cell cycle and correlated with sensitivi

205 inylation and altered the hydrophobicity and rigidity of the cell envelope of the bacilli without sig

206 the linking groups that likely enhances the rigidity of the channel-forming topologically complex mo

207 an be smoothed out by increasing the bending rigidity of the coat, allowing for successful budding at

208 we demonstrated that AdipoRon decreased the rigidity of the colonic cell PM.

209 The small size and rigidity of the Czon1107 peptide could provide a scaffol

210 f helical membrane tubes and helps infer the rigidity of the described protein filaments.

211 utes that describe the spatial structure and rigidity of the entire genomic site as well as those sur

212 The bending rigidity of the ER tubule membranes was found to be 10.9

213 t and the Li-metal anodes is poor due to the rigidity of the garnet, which leads to limited active si

214 rlinked complex 1, evidence of the increased rigidity of the ligand sphere in 1 was provided by proto

215 starting point, we optimized the length and rigidity of the linker and its position along the peptid

216 lighted the importance of (i) the nature and rigidity of the linker between the two moieties for inhi

217 g on the substrate curvature and the bending rigidity of the lipid domains.

218 to emit with intensities that depend on the rigidity of the medium.

219 LPS-binding surfactant that destabilizes the rigidity of the outer membrane to exert pleiotropic effe

220 e beta-turns of the macrocycle preserved the rigidity of the parent scaffold, whereas peptoid substit

221 The latter results from rigidity of the poly(rA/dT) tract and leads to base-pair

222 t times increase drastically with increasing rigidity of the RBC membrane.

223 ctral range remains a challenge owing to the rigidity of the resonator for the generation of coherent

224 We link this effect to the rigidity of the retinal protein environment.

225 perconducting phase, able to break the phase rigidity of the system.

226 ) over Xe in DD3R zeolite membranes, whereby rigidity of the zeolite structure plays a key role.

227 he response of muscle cell precursors to the rigidity of their environment, but the mechanisms explai

228 udy demonstrate that T cells sense the local rigidity of their environment, leading to strategies for

229 The rigidity of these systems with respect to external pertu

230 and core components of radicalization (e.g., rigidity of thoughts, hot-cognitive defense of cultural

231 but with solid-like out-of-plane compressive rigidity offer unique opportunities for achieving unusua

232 e effect of actin polymerization and nuclear rigidity on the diffusive behavior of the nucleus.

233 e rod and hook, respectively, conferring the rigidity on the rod and flexibility on the hook.

234 To introduce more rigidity, one of the tpy units of the tris-dentate ligan

235 are reported here for elucidating increased rigidity or flexibility of MscL when bound to various ph

236 ently invoked factors such as conformational rigidity or fundamental length-scale limitations.

237 geometric states by either increasing matrix rigidity or micropatterning primed cell shapes, fibrobla

238 the paramagnetic centre, seeking to increase rigidity or remove elements with nuclear spins or both.

239 cally demonstrates bradykinesia with tremor, rigidity, or both.

240 terol's role in controlling membrane bending rigidity over mesoscopic length and time scales of impor

241 eir cognate ligand: KIR3DL1*015/HLA-Bw4 from rigidity (p (c) = 0.02, odds ratio [OR] = 0.39, 95% conf

242 IR3DL1/HLA interactions were associated with rigidity (p(c) = 0.05, OR = 9.73, 95% CI 2.13-172.5).

243 ubiquitous biomacromolecule DNA has an axial rigidity persistence length of ~50 nm, driven by its ele

244 ostic motor (hypo- and bradykinesia, tremor, rigidity, postural imbalance, postural abnormalities) an

245 mpares random coil index [RCI] against local rigidity predicted by mathematical rigidity theory, calc

246 in a perpendicular orientation, and spindle rigidity prevents spindle bending that can lock both pol

247 Two-dimensional (2D) substrate rigidity promotes myosin II activity to increase tractio

248 nd fibers, and their remarkable strength and rigidity provide strong mechanical support to the cells

249 Cs to maintain a fibrotic ECM, with external rigidity providing feedback which affects MMP-9 and TIMP

250 tomeric substrates with controlled patterned rigidity ranging from the micrometer to the nanoscale is

251 triggers an increase in protein multidomain rigidity, reducing conformational flexibility of F-actin

252 ws the silicified fibrils with large bending rigidity, reflected in hydrogels with elasticity three o

253 cells globally adapt, detect, and respond to rigidity remains unknown.

254 eton organization, traction forces, and cell-rigidity responses at both the adhesion and cell scale.

255 nt cells exhibited increased plasma membrane rigidity, resulting in reduced azole accumulation and co

256 nsonian features, including bradykinesia and rigidity, return) of greater than 1.5 hours per day (exc

257 Thus, EGFR or HER2 can catalyse rigidity sensing after associating with nascent adhesion

258 sin cytoskeleton and its coupling with local rigidity sensing at focal adhesions in the regulation of

259 ntegrin adhesions has been well studied, but rigidity sensing by cadherins during cell adhesion is la

260 Extracellular matrix (ECM) rigidity sensing by integrin adhesions has been well stu

261 signaling molecules activated by E-cadherin rigidity sensing on PA gels contribute to actin organiza

262 The recently defined rigidity sensing process provides a good example of how

263 EGFR or HER2 activity increase spreading and rigidity-sensing contractions on rigid, but not soft, su

264 role of active and passive cross-linkers in rigidity-sensing responses.

265 were stronger and correlated to bradykinesia-rigidity severity.

266 positively associated with bradykinesia and rigidity severity; however, these clinical associations

267 ted in a minimally invasive fashion; but the rigidity, size, and potential toxicity of the involved l

268 inson disease-like movement problems such as rigidity, slowness, and tremor.

269 yl groups was shown to have the right mix of rigidity, solubility, and ease of synthesis.

270 demonstrated in the cortical bone structure, rigidity, stiffness, and modulus of the HGPS G608G mouse

271 asures show different responses to substrate rigidity, suggesting competing processes in overall T ce

272 Despite its size and rigidity, the cell nucleus can be moved or reorganized b

273 nst local rigidity predicted by mathematical rigidity theory, calculated from NMR structures [FIRST],

274 fat crystal morphology and increased network rigidity, through the binary variable zeta.

275 eased lipid membrane has a 25% lower bending rigidity, thus destabilizing smooth [Formula: see text]u

276 rix by CAFs has been shown to increase tumor rigidity to indirectly regulate FAK Y397 phosphorylation

277 Despite conferring rigidity to support plant structures, the cell wall is a

278 erves as a permeability barrier and provides rigidity to the cell.

279 n the topographies of the brain, and provide rigidity to the fragile tissue while eliminating backgro

280 chromosome integrity and provides mechanical rigidity to the nucleus(1,2).

281 ochemistry, imparting significant structural rigidity to the peptide backbone that resulted in augmen

282 force, stress, and strain but also substrate rigidity, topology, and adhesiveness.

283 lus and shear modulus discontinuities at the rigidity transition as well as the magnitude of the Poyn

284 Rigidity, tremor, and dysarthric side effects seem to be

285 file for bradykinesia differed from that for rigidity, tremor, or dysarthria.

286 ochemical DNA sensors, the increase in probe rigidity upon target hybridization alters the accessibil

287 The decrease in membrane rigidity was associated with a reduction in PM free chol

288 veness in reducing bradykinesia, tremor, and rigidity was evaluated for each electrode contact in bra

289 Rigidity was mitigated by stimulation of ascending brain

290 cal moduli, such as torsional and dilational rigidity, which correspond to the protein's effective sh

291 by the nucleotide moiety increases membrane rigidity, which enhances the fluorescence of a common re

292 This is probably due to their high rigidity, which hinders some of the peptide catalysts to

293 f a bioactive molecule offers conformational rigidity, which in turn reduces the penalty for conforma

294 the carbon chain length increases, and their rigidity, which makes deformation from the ground-state

295 ochromatin increases chromatin-based nuclear rigidity, which protects nuclear morphology and function

296 reases heterochromatin and chromatin nuclear rigidity, which results in reduced nuclear blebbing in l

297 to a threefold increase in effective bending rigidity with increasing cholesterol content approaching

298 -kappaB expression and tenascin C-associated rigidity, with p-Mypt1 inactivation/actinomyosin-mediate

299 oated polyacrylamide gels to alter substrate rigidity without altering ligand density, we show that f

300 and novel tenascin C, indicative of elevated rigidity; yet despite continued ROCK2 activities/p-Mypt1