ライフサイエンスコーパス: rigidly

1 s human infants to perform habitual behavior rigidly.

2 shift may be more effective than engaging ER rigidly across time.

3 groove binding A-B-C+ risaccharide moieties rigidly anchor the enediyne in the minor groove such tha

4 one, indicating that the fatty acids are not rigidly anchored in the cavity, but move within the pock

5 support the view that the fatty acid is not rigidly anchored within the I-FABP binding pocket, but r

6 while the C-terminal hexapeptide segment is rigidly anchored within the orthosteric pocket.

7 ts suggest that this isozyme participates in rigidly anchoring stereocilia; and finally, colocalizati

8 es were registered with simulation CT images rigidly and by using four deformable image registration

9 of protein flexibility via identification of rigidly and nonrigidly repositioned fragments, stable an

10 oxyl-4-amino-4-carboxylic acid, the probe is rigidly and stereospecifically coupled to the alpha-carb

11 y light chain (RLC) using a spin-label bound rigidly and stereospecifically to the single Cys-154 of

12 These bonds hold the transition structure rigidly and thus allow the catalyst triphenylsilyl group

13 a triad of residues (R48C, W51C, and His52) rigidly arranged on one alpha-helix is responsible for c

14 andem death effector domains (DEDs) of MC159 rigidly associate with each other through a hydrophobic

15 ld of DED1, a dumbbell-shaped structure with rigidly associated DEDs and a different mode of interact

16 Th2 cytokine remained strong because it was rigidly associated with Th2 clones in mice, whereas both

17 ely, on bare Al2O3, the latex particles were rigidly attached as compared to the more loosely attache

18 Spin labels that are more rigidly attached to a base in an oligonucleotide experie

19 The SUN2 domain is rigidly attached to a trimeric coiled coil that preposit

20 in vitro as single molecules or as ensembles rigidly attached to nonbiological substrates.

21 the nitroxide-containing ring covalently and rigidly attached to the alpha-carbon, providing direct i

22 distances between two nitroxide spin labels rigidly attached to the helices of the dimer was determi

23 e feasibility and usefulness of a GFP moiety rigidly attached to the protein of interest as a probe f

24 pproach requires a fluorescent probe that is rigidly attached to the protein of interest.

25 of a target-binding nanobody, which is then rigidly attached to two scaffolds: 1) a Fab fragment of

26 These sound diffusers are rigidly backed slotted panels, with each slit being load

27 ng is a new behavioral mechanism by which MA rigidly biases choice behavior.

28 gid docking and induced fit, with TruB first rigidly binding to its target and then maximizing the in

29 Decades of experimental results show that a rigidly body-fixed tethered fly in a "virtual reality" v

30 reases in the anisotropy associated with the rigidly bound multiuse affinity probe 4',5'-bis(1,3,2-di

31 and receptors that are tethered rather than rigidly bound on a cell surface.

32 ized, moves closer to the flavin occupying a rigidly bound state participating in the hydrogen-bond n

33 bsence of ATP, when all the myosin heads are rigidly bound to the thin filament), a slight decay was

34 btained; four-eclipsed substituents are held rigidly by the bicyclic addends.

35 y typically arises in molecules because of a rigidly chiral arrangement of covalently bonded atoms.

36 ates increased with Ca (systole), suggesting rigidly closed conformations for the E1 (Ca-bound) enzym

37 he uniqueness of gold chemistry applied to a rigidly closed shell system in an unconventional way.

38 ure observed in complex with RNA but are not rigidly confined (i.e. they move independently) in solut

39 port on the orientation of NPC components by rigidly conjugating mEGFP to different NPC proteins.

40 bN), reveals a globular entity formed by two rigidly connected cyclin-like folds.

41 Transmission through the rigidly connected plexin/semaphorin/integrin (PSI) domai

42 the virion (domains 1 and 2) are aligned and rigidly connected, whereas domain 3 diverges at an angle

43 ogues as B-class organ-identity genes is not rigidly conserved among all angiosperms.

44 H and S) mutations have been engineered at a rigidly conserved aromatic residue, W63, of the isolated

45 indicates that there are probably no large, rigidly conserved cis-acting nucleic acid sequences requ

46 pgl gene cluster mediates the synthesis of a rigidly conserved heptasaccharide that is attached to pr

47 how this genome flexibility occurs within a rigidly conserved shell, we determined the high-resoluti

48 reme evolutionary flexibility, the locus has rigidly conserved structural features.

49 ntal and early process does not appear to be rigidly constrained by evolutionary pressures; instead,

50 tegic disulfide bonds, creating well-folded, rigidly constrained Fabs applicable across various speci

51 o amide bonds in the inter-cysteine loop are rigidly constrained to cis conformations.

52 e of little importance, or that managers are rigidly constrained with no flexibility to adapt, in whi

53 eptor units, relative to the spacer, are not rigidly constrained, and their torsional motions decreas

54 ted that binding of Runx1 to the enhancer is rigidly controlled at the level of chromatin accessibili

55 Evidence now suggests that fibrinolysis is rigidly controlled by endogenous fibrinolysis inhibitors

56 onventional potato, carrot, and cabbage from rigidly controlled long-term field trials and from a cas

57 first chemically assembled into chains with rigidly controlled separations of 0.9 nm primed for re-s

58 If environmental conditions are rigidly controlled, this method is very sensitive for de

59 alphabeta TCRs, which have TCR ECDs that are rigidly coupled to its transmembrane (TM) domains.

60 ellular one-half of S4 during activation are rigidly coupled to lateral movement of the S4-S5 linker,

61 e-binding clefts could be closed if they are rigidly coupled to switch I.

62 l and monomeric PLB mutant with a spin label rigidly coupled to the backbone of the transmembrane hel

63 a thin illumination sheet whose position is rigidly coupled to the objective and aligned with its fo

64 lia are filled with actin filaments that are rigidly cross-linked.

65 tion that cannot be met by a small number of rigidly defined neuronal populations.

66 ay be that the DNA-binding HTH motif becomes rigidly defined only when FlhD forms a complex with some

67 when attempting to model sequences with less rigidly defined structures, such as messenger and non-co

68 aper follows a rather narrowly (but not ever rigidly) defined pattern.

69 e their spacing and that NF spacing does not rigidly determine axon diameter.

70 gesting that phosphorylation of NFs does not rigidly determine their spacing and that NF spacing does

71 plexities of insect reproduction, their more rigidly determined altricial patterns of social behaviou

72 ne-PET/CT group, radiotherapy decisions were rigidly determined by PET findings, which were also used

73 light is polarized in an orientation that is rigidly determined by the position of the sun, this cue

74 oxyl end of the fatty-acid spin label is not rigidly docked on the protein.

75 The filament model obtained by rigidly docking a chicken smooth muscle myosin structure

76 e mobility of radical intermediates but also rigidly encapsulates the substrate, intermediates, and p

77 o not have severe geometric constraints that rigidly enforce unusual geometries.

78 owever, there is an increasing evidence that rigidly enforced hierarchies lead to a decrease of coope

79 We show that the bound cargo protein is held rigidly enough to visualize it at a resolution of 3.8 an

80 nitial purity and stability of agonists were rigidly ensured and quantitatively assessed.

81 gratory specificity of the LGE precursors is rigidly established between E12.5 and E14.5.

82 that the 5'-adenine of the triloop, which is rigidly fixed ("clamped") to the stem, is a key recognit

83 Isolated whiskers rigidly fixed at the base showed first-mode resonance pe

84 zero in the bound state (i.e., the ligand is rigidly fixed in the binding pocket).

85 The branch points, which are rigidly fixed in these junctions in their free forms, te

86 red by the elasticity modulus) compared with rigidly fixed LH, and also the force needed to initiate

87 We report that Synaptotagmin remains rigidly fixed on the partially assembled SNARE complex w

88 alysis reveal that the tag does not assume a rigidly fixed position, but instead can be found at vari

89 ironment, it was possible to image molecules rigidly fixed to the substrate and the motion of single

90 r hindlimbs, whereas the head and trunk were rigidly fixed.

91 proximal CL as the building foundation that rigidly fixes the ciliary orientation, and the distal CL

92 in freely moving animals can be obtained by rigidly fixing ('anchoring') the pipette electrode to th

93 ular faces exhibit two-dimensional spaces of rigidly foldable cylindrical configurations.

94 A more rigidly folded D-loop may explain some of the previously

95 enerically change sign as the crease pattern rigidly folds between degenerate ground states and we de

96 We first rigidly fuse DHRs to HBs to generate a large library of

97 describe a general computational method for rigidly fusing homo-oligomer and spacer building blocks

98 joint that has limited movement and is often rigidly guarded.

99 The two rigidly held aromatic rings of SCA-alpha2 form a right-h

100 apping the double helix around the ring, are rigidly held in an orientation distinct from that seen i

101 ior observed for the duplexes containing the rigidly held Ru(II) center originates, at least partiall

102 It is known this C-terminal region becomes rigidly held when FlgM binds sigma 28, and it is possibl

103 tom of psychosis, are false beliefs that are rigidly held with strong conviction despite contradictor

104 reen fluorescent protein (GFP) expressed and rigidly held within the amino acid sequence of a major h

105 ascribed to a hydrophobic environment and a rigidly held, open conformation of NADH, features in acc

106 Klenow fragment the templating base is more rigidly held, so that changes in base pair geometry woul

107 Thus, the results do not support a rigidly hierarchical model of nervous system organizatio

108 This probe is rigidly immobilized on the catalytic domain of the head,

109 nevertheless overcome diffraction and travel rigidly in free space, are a long sought-after field str

110 emase has a positively charged arginine held rigidly in place by an extensive hydrogen bond network t

111 he TTD and the enzyme that hold the TTD more rigidly in place.

112 bust than methods in which the constraint is rigidly incorporated, such as hybrid linear analysis, wh

113 Here we show that these rigidly inserted Cy3/Cy5 chromophores also exhibit two a

114 gy transfer fluorophore pairs that have been rigidly inserted into the backbones of replication fork

115 If these criteria are rigidly interpreted, it may be that, by the time medical

116 The rigidly linear monomers condense to form extended solids

117 h occurs regioselectively at only one of the rigidly linked dendrons.

118 proliferation and effector function are not rigidly linked in T cells.

119 with the observation that the spin-label is rigidly linked to band 3 in a fixed orientation with res

120 t cues, yet increases in beta power were not rigidly linked to cues, movements, or movement suppressi

121 and a central free base porphyrin (H2P)-all rigidly linked to each other-serve as light-harvesting a

122 We conclude that MSTd responses are not rigidly linked to specific stimuli, but rather are trans

123 urements, our data indicate that the MreB is rigidly linked to the cell wall, increasing the mechanic

124 ternal cognitive states because they are not rigidly linked with either specific sensory stimuli or t

125 ymphoma kinase (ALK) inhibitors, designed to rigidly lock an energy-minimized bioactive conformation

126 The polyene chain is rigidly locked into a single, twisted conformation, cons

127 Therefore, it appears that the SF is so rigidly locked into the TALK-2 protein structure that ch

128 sonance (EPR)-active spin probe that is more rigidly locked to the DNA than any previously reported,

129 sFRP1/5 and Dkk3 levels are rigidly maintained via autorepressive and cross-repressi

130 Stable fragments rarely coincide with rigidly moving fragments and often disagree with the CAT

131 of protein fragments and compare stable and rigidly moving fragments.

132 outer hair cells are constrained neither too rigidly nor too weakly.SIGNIFICANCE STATEMENT Mammals ca

133 ce structure and requires that the atoms fit rigidly on that lattice.

134 proximately 0.16 and 0.25 and also show that rigidly ordered phases seem to disappear around chi(chol

135 the naked mole-rat, a species with the most rigidly organized reproductive hierarchy among mammals.

136 Aergic postsynaptic specializations are less rigidly organized than glutamatergic postsynaptic densit

137 The acquired knowledge was rigidly organized, and performance collapsed when the ta

138 Thus, what E.P. learned was rigidly organized, unavailable as conscious knowledge, a

139 orce its conjugated diene double bonds to be rigidly oriented 32 degrees out-of-plane.

140 n the power stroke (weak-binding states) and rigidly oriented later in the power stroke (strong-bindi

141 indicate that bound alpha-neurotoxin is not rigidly oriented on the surface of AChBP but rather exhi

142 lative orientation of the two domains is not rigidly oriented with respect to one another in solution

143 protein or possibly because the core is not rigidly packed in wild-type PLB.

144 For the rigidly packed residues, the average RMSD to the mean st

145 tion motif in which His and Glu residues are rigidly placed in a tetrahedral geometry.

146 e trifluoromethyl ketones by incorporating a rigidly positioned carbonyl group to participate in a hy

147 hrough a structural change where EDTA-U24 is rigidly positioned out of the helix and cannot get acces

148 that like GFP the tetrameric form of HAL is rigidly preorganized for cyclization.

149 However, sustained gene transcription is rigidly prevented to avoid lethal STING-dependent proinf

150 Furthermore, far from being rigidly programmed by the original activating stimulus,

151 ning from training data rather than by being rigidly programmed.

152 cells to quantitatively respond to substrate rigidly provides an intriguing new model for mechanobiol

153 ely automatic software package to normalize, rigidly register and elastically match serial whole-body

154 .5% for unregistered, rigidly registered and rigidly registered + matched images, respectively.

155 of 73.4%, 78.7% and 91.5% for unregistered, rigidly registered and rigidly registered + matched imag

156 Non-rigidly registered images of a silica-supported platinum

157 st overall reproducibility was obtained with rigidly registered phase 1 and phase 2 images, with with

158 Preprocedural FDG PET scans were rigidly registered through a semiautomatic method to int

159 nstructed without attenuation correction and rigidly registered to a reference frame.

160 Patient images were rigidly registered together, and intratumor tracer uptak

161 findings suggest that substrate is held more rigidly relative to the oxidizing species at low tempera

162 he blocks maintaining their identity, namely rigidly rotating.

163 The meshes were rigidly scaled to different volumes, and S values were t

164 rpyridyl-palladium-ligand (terpy-Pd-L) units rigidly separated by about 7 A has been investigated for

165 Formerly rigidly separated research efforts in academic instituti

166 cal conductivity and doping concentration is rigidly shifted toward that direction without disturbing

167 nlike motoneurons, may not yet have acquired rigidly specified identities and/or the ability to recog

168 ckly stopped, suggesting that Z rings became rigidly stabilized in the absence of GTP hydrolysis.

169 nsport is less discriminate than in the more rigidly stacked DNA double crossover assemblies.

170 Syntactic CCGs in the field (a) were more rigidly stereotyped than ordinary syntactic CCGs in the

171 state in the early steps of activation to a rigidly structured open state.

172 s, proteusin leaders are preorganized into a rigidly structured region and a smaller intrinsically di

173 pped onto the disordered region, leaving the rigidly structured region of the proteusin leader to be

174 ue challenges faced by a highly contractile, rigidly structured, and long-lasting cell.

175 reas in the inactive state the water is more rigidly structured.

176 The proximal and the distal Fabs are rigidly tethered to the Fc.

177 le, site-specific modified base containing a rigidly tethered, electron paramagnetic resonance active

178 ated with viral nucleoprotein complexes more rigidly than mature capsid and NC.

179 s work suggesting that the 5'-T is held more rigidly than the 3'-T.

180 s a self-assembling oligomer, A(n), is fused rigidly to one molecule of protein B, which forms anothe

181 4-amino-4-carboxylic acid), which is coupled rigidly to the alpha-carbon, providing direct detection

182 s, with tens to thousands of lenses attached rigidly to the exoskeleton.

183 that a model in which CTD units are attached rigidly to the parallel beta-sheet core is consistent wi

184 s of 25 +/- 4 water molecules that are bound rigidly to the protein for a time long compared with the

185 Fab 5F10 fixes the B domain rigidly to the surface of the virus, blocking exposure o

186 stance between the structures (appropriately rigidly transformed).

187 e largest structural variations, not the one rigidly trapped in a deep, but narrow, conformational en

188 The upper peak overlapped and displaced rigidly with the crural sling, while the distal peak sep

189 2.7 ns) than it could if it were interacting rigidly with the iSH2 domain.

190 ongitudinal asymmetries that corotate nearly rigidly with the planet.

191 The molecular O(2) is trapped rigidly within vacancy clusters and exhibits minimal mob