ライフサイエンスコーパス: rigor

1 this state to the subsequent state on actin (Rigor).

2 arch culture that has led to shortcomings in rigor.

3 ut only two of these (C2 and C4) remained in rigor.

4 and by ASCO methodologists for developmental rigor.

5 sensitivity and is justified in statistical rigor.

6 resting part of biology to three-dimensional rigor.

7 es in relaxation, isometric contraction, and rigor.

8 their assumptions with similar quantitative rigor.

9 illations imposed on single muscle fibres in rigor.

10 can be verified with traditional scientific rigor.

11 es, raising concerns about potential lack of rigor.

12 nearly crystalline order of myosin heads in rigor.

13 es in relaxation, isometric contraction, and rigor.

14 nd inconsistent, and it lacks methodological rigor.

15 consistent across all levels of methodologic rigor.

16 vestigated, study design, and methodological rigor.

17 a high, medium, or low level of methodologic rigor.

18 emistry or displaying hyperthermia or muscle rigor.

19 ess" expertise is as important as scientific rigor.

20 onal dynamics indistinguishable from that of rigor.

21 ed significant variability in methodological rigor.

22 nalysis may enable enhanced vigor as well as rigor.

23 ctive equipment while maintaining scientific rigor.

24 o investigator bias and a lack of scientific rigor.

25 a haphazard enterprise without discipline or rigor.

26 e stiffness of skeletal muscle myofibrils in rigor.

27 d significant improvements in methodological rigor.

28 attention should be given to methodological rigor.

29 and by ASCO methodologists for developmental rigor.

30 to stimulate its scientific advancement and rigor.

31 ses and interpreting results with scientific rigor.

32 Firestone & Scholl (F&S) in calling for more rigor.

33 ds to be guarded against with scepticism and rigor.

34 dies (5; 13%), did not assess methodological rigor (10; 26%), did not conduct comprehensive searches

35 minus-end directed myosin VI motor domain in rigor (4.6 A) and Mg-ADP (5.5 A) states bound to F-actin

36 SH1-SH2 cross-linked (A.M'.D.P analog), and rigor (A.M.D).

37 High pressure processing (HPP) of post-rigor abalone at 300MPa for 10min extended the refrigera

38 response rate) perceived the level of study rigor accurately.

39 activity of isolated myosin, but it impairs rigor actin binding and actin-activation of myosin ATPas

40 During isometric contraction, but not during rigor, actin orientation oscillated between two values,

41 Interestingly, rigor activation was unchanged between the wild type and

42 ns of the cleft interconverting, even in the rigor actomyosin complex.

43 o an experimentally determined EM map of the rigor actomyosin.

44 nditions that normally destabilize it, e.g., rigor ADP.

45 Researchers assume sampling rigor alone will lead to an accurate detection of respon

46 he CAP/IASLC/AMP guideline for developmental rigor; an ASCO ad hoc review panel of experts reviewed t

47 ed the SSO/ASTRO guideline for developmental rigor; an ASCO ad hoc review panel of experts reviewed t

48 al infarct-sparing therapies with a level of rigor analogous to multicenter, randomized, controlled c

49 unresolved because of a lack of statistical rigor and appropriate evolutionary framework.

50 ion of myo2-E1 and myo2-E1-Sup1 on available rigor and blebbistatin-bound myosin II structures sugges

51 uent HTx and assessed studies for scientific rigor and clinical relevance.

52 is an important step toward ensuring greater rigor and comparability of pediatric tuberculosis diagno

53 Cancer was reviewed by ASCO for methodologic rigor and considered for endorsement.

54 We make recommendations to improve the rigor and consistency of modeling of health co-benefits.

55 The guideline was reviewed for developmental rigor and content applicability.

56 CCO guideline was reviewed for developmental rigor and content applicability.

57 nal validation framework supports scientific rigor and creativity, as opposed to the oft-repeated sug

58 on of this program is to leverage scientific rigor and cross-program collaboration to advance the sci

59 onary disease had shorter time to enter into rigor and developed greater ischemic contracture.

60 For both factors studied (rigor and funding), one of the three possible variations

61 s to natural stimuli can be studied with the rigor and interpretability defining work with simpler st

62 t experience-based paradigm lacks scientific rigor and is subject to the inaccuracies that plague ane

63 y probability varies among fiber states with rigor and isometric contraction at extremes where straig

64 As with clinical trials, the rigor and methods of the analysis are critical to the re

65 We also study actin-free myosin in both rigor and post-rigor conformations.

66 Recent open science efforts to improve rigor and reliability have sparked great enthusiasm.

67 Overall methodological rigor and reporting of guidelines varied from fulfilling

68 and molecular or genetic modification create rigor and reproducibility challenges for HCMV latency st

69 iological repository to foster transparency, rigor and reproducibility in metabolic physiology experi

70 A major reason is insufficient rigor and reproducibility in preclinical studies.

71 e and focuses attention on the necessity for rigor and reproducibility in scientific research.

72 nt applicants have been asked to address the rigor and reproducibility of their proposed projects.

73 f reporting guidelines needed to improve the rigor and reproducibility of this valuable translational

74 ables large, diverse data sets; and supports rigor and reproducibility.

75 ) public benefit; 3) standards of scientific rigor and reproducibility; 4) transparency; 5) equity; 6

76 We also examined post-rigor and rigor conformations across several myosin spec

77 Methodological rigor and scope were variable.

78 echniques should be examined with scientific rigor and should demonstrate both a significant benefit

79 ls was associated with significantly reduced rigor and subsequent detection rates compared with asses

80 preclinical research as part of the agency's rigor and transparency initiative.

81 The AGREE II instrument was used to evaluate rigor and transparency of guideline development.

82 We sought to assess the methodological rigor and transparency of reporting of clinical practice

83 aff reviewed the guideline for developmental rigor and updated the literature search.

84 nd to analyze the findings in terms of their rigor and usefulness for global nutrition research and p

85 analytic methods have emerged and evolved in rigor and utility.

86 Incorporating both rigor and vigor into studies will provide a fuller under

87 However, the existing methods often lack rigor and/or computational efficiency and consequently d

88 parities researchers face tradeoffs between "rigor" and "vigor" in designing studies that demonstrate

89 tween actin-attached (strong binding: ADP or rigor) and actin-detached (weak binding: ATP or ADP.P(i)

90 reviewed the CCO guideline for methodologic rigor, and an ASCO panel of content experts reviewed the

91 trials had high, medium, or low methodologic rigor, and each report included one of three support dis

92 ribution intermediate between relaxation and rigor, and saturation transfer EPR revealed slow rotatio

93 mbines the ecological validity, experimental rigor, and sensitive measures required to investigate th

94 underlying the regulations lack quantitative rigor, and the rules they enforce impose costly bureaucr

95 s considerations related to trustworthiness, rigor, and transparency.

96 ndrome (grade 1 to 2) which included chills, rigors, and fever.

97 the emergency department with fever, chills, rigors, and upper abdominal discomfort.

98 t lacking methodologic quality, particularly rigor applied during the development process.

99 ented and proposals for practices to improve rigor are appearing.

100 to perform investigations with unprecedented rigor are growing increasingly common in neuroimaging.

101 Additional studies with methodologic rigor are needed for a better understanding of the roles

102 ficers are encouraged to strive for analytic rigor as well as public health consequence, which requir

103 cells for targeted therapy, but the cost and rigor associated with manufacturing engineered T cells e

104 -activated ATPase, actin-sliding velocities, rigor binding to actin, and kinetics of ATP binding and

105 Here, we used rigor-binding mutants of kinesin-1 as roadblocks to perm

106 large range of S2 angles indicates that some rigor bridges produce positive force that must be balanc

107 ed actin filaments in the absence of ATP (in rigor), but also close to those of the pair of heads fol

108 criminate among trials of varying degrees of rigor, but industry sponsorship negatively influences th

109 ramework of atomic detail and stereochemical rigor by conducting all-atom molecular dynamics and Brow

110 S guidelines were reviewed for developmental rigor by methodologists, and an independent multidiscipl

111 s of Oncology was reviewed for developmental rigor by methodologists, with content and recommendation

112 cer guideline was reviewed for developmental rigor by methodologists.

113 ladder cancer was reviewed for developmental rigor by methodologists.

114 e Guidelines were reviewed for developmental rigor by methodologists.

115 ion Oncology, was reviewed for developmental rigor by methodologists.

116 tment of SCLC was reviewed for developmental rigor by methodologists.

117 prostatectomy was reviewed for developmental rigor by methodologists.

118 cer guideline was reviewed for developmental rigor by methodologists.

119 Breast Cancer was reviewed for developmental rigor by methodologists.

120 Cancer (HRPC) was reviewed for developmental rigor by methodologists.

121 work-up of AL was reviewed for developmental rigor by methodologists.

122 glioblastoma was reviewed for developmental rigor by methodologists.

123 are Guideline was reviewed for developmental rigor by methodologists.

124 l Lung Cancer was reviewed for developmental rigor by methodologists.

125 These communities of rigor champions would also assist in the development and

126 this issue, we propose that communities of 'rigor champions' be established to campaign for reforms

127 fatigue, anorexia, anemia, diarrhea, nausea, rigors/chills, leukopenia, fever, and transaminase eleva

128 Comparison to the myosin IIC-F-actin rigor complex reveals an almost complete lack of conserv

129 We consider results obtained both under rigor conditions (in the absence of ATP) and during acti

130 of myofilament longitudinal stiffness under rigor conditions demonstrated a significant reduction in

131 moduli amplitude under active, passive, and rigor conditions suggest that median-aged fibers become

132 osin binding can switch on thin filaments in rigor conditions, it does not contribute significantly u

133 ed, upon maximal Ca(2+) activation and under rigor conditions, lower stiffness and disrupted actin-la

134 lead head rebinds to the motor and attains a rigor conformation when the rear head detaches.

135 as a closed actin-binding cleft, to the post-rigor conformation, in which the cleft is open.

136 the direction of their displacement from the rigor conformation, which has a closed actin-binding cle

137 We also examined post-rigor and rigor conformations across several myosin species.

138 udy actin-free myosin in both rigor and post-rigor conformations.

139 ge effect that grades with distance from the rigor cross-bridge for both cTn and sTn.

140 nce of MgATP(2-), the condition conducive to rigor cross-bridge formation, further increased the appa

141 Comparison to previous work on single rigor cross-bridges at the A-band periphery where the my

142 In rigor, cross-bridges at low concentration at the end of

143 For some GLs, the "Scientific rigor" domain flawed.

144 itical values, invoking scientific criteria (rigor, etc.) as their justification.

145 usness of variations entails an experimental rigor even greater than traditional Sanger sequencing-ba

146 tion of TnC-reduced I-band and overlap Ca in rigor fibers at pCa 5.6 to the same levels found in unex

147 The angle between these two RLC lobes in rigor fibers was different from that in the crystal stru

148 However, when 1% stretch was applied to the rigor fibers, the lifetime decreased for ELC-127 and ELC

149 s in a holding tank before being killed, pre rigor filleted and stored in ice.

150 he subsequent effect on flesh quality of pre-rigor filleted Atlantic salmon (Salmo salar L.) was inve

151 es meets current standards of methodological rigor for evidence-based interventions is not clear.

152 constrained functionals sacrificing physical rigor for the flexibility of empirical fitting.

153 n interventions demonstrating methodological rigor has been increasing.

154 h anecdotal reporting, but little scientific rigor, has been applied to the study of methods to impro

155 Examples of lack of rigor have been extensively documented and proposals for

156 for the first bond to form between actin and rigor heavy meromyosin and the load-dependent durations

157 hly disordered and microsecond dynamics) and rigor (highly ordered and rigid), supporting the hypothe

158 t least 1 of the following symptoms: emesis, rigors, hypotension, or flank pain.

159 least one of the following symptoms: emesis, rigors, hypotension, or flank pain.

160 a large patient cohort structured to ensure rigor in data collection, analysis, and interpretation.

161 kelihood of successful translation depend on rigor in experimental design, interpretation, and report

162 ive standards, and the potential for greater rigor in experimental research.

163 Methodological rigor in families research also continues to increase, w

164 th ASCO's abiding commitment to methodologic rigor in guideline development.

165 nt small RNA discovery, demands an increased rigor in miRNA annotations.

166 The degree of rigor in model development and assessment can vary great

167 Methodological clarity and rigor in terms of biomarker discovery, validation and te

168 with an emphasis on the need for scientific rigor in the preclinical stage.

169 ed temperature gave increased blood lactate, rigor index (Ir), drip loss (DL), content of astaxanthin

170 ence in functional maturation, they lack the rigor inherent in controlled animal experiments.

171 terfilament spacing (from 52 nm to 67 nm) of rigor insect flight muscle fibers and exposes a tetherin

172 Increasing rigor is being applied to medical decision making, but m

173 More rigor is needed in tracking sepsis after trauma and eval

174 a priori outcome of interest and statistical rigor jeopardizing estimations of potential effect size.

175 ore, binding B-lattice GDP microtubules to a rigor kinesin surface stabilizes them against shrinkage,

176 i-pSer-35 but not by anti-Ser-35, whereas in rigor, labeling was similar with both.

177 in two slightly different renditions of the rigor-like conformation with a citrate of crystallizatio

178 releases its secretory cargo, defining a new rigor-like state of a myosin V in vivo.

179 ly transporting Myo2 can be converted to the rigor-like state.

180 leotide-free states of myosins-known as the "rigor-like" state.

181 This inhibition results in 'rigor-like', tight association with microtubules in vitr

182 ent findings and questionable methodological rigor make drawing conclusions difficult.

183 mptoms, including fever (>/=38.5 degrees C), rigors, malaise, lethargy, flank pain, hematuria, suprap

184 ibrillar proteins may be related to the meat rigor mortis and quality development.

185 residues in a closed active site in the post-rigor motor domain undergo subtle structural variations

186 Here we used electron tomography of rigor muscle swollen by low ionic strength to pull S2 cl

187 populations, a high level of methodological rigor must be maintained and studies should report suffi

188 e assembly pathway that involves both an Eg5 rigor mutant and the kinesin-12 Kif15.

189 expression of wild-type kinesin-5, but not a rigor mutant of kinesin-5, has the inverse effect on axo

190 ying the behavior of SVs and EEs in null and rigor mutants of kinesin-3 and kinesin-1 (UncA and KinA,

191 a function of pCa and labeled Tn exchange in rigor myofibrils was used to estimate Tn dissociation ra

192 Binding of rigor myosin heads to thin filaments following MgATP dep

193 show that the azimuth of S2 origins of those rigor myosin heads, bound to the actin target zone of ac

194 binding sites on F-actin so that binding of rigor myosin is required to fully activate the thin fila

195 uncomplicated colonoscopic polypectomy with rigors, nausea, vomiting and right upper quadrant pain.

196 standing cell-entry and trafficking with the rigor needed to engineer tissue-specific vectors.

197 sible cardiac myofilament lattice induced by rigor not observed in the NTG and WT(t/t).

198 of funding, led physicians to downgrade the rigor of a trial (odds ratio, 0.63; 95% CI, 0.46 to 0.87

199 xpressiveness of rules with the mathematical rigor of Bayesian networks (BNs) to develop and evaluate

200 help to improve the logical and ontological rigor of bio-medical ontologies such as the OBO relation

201 The summary scores of the rigor of development (median, 28.6% [range, 16.7% to 100

202 ers should be aware of the difference in the rigor of development and quality of reporting of guideli

203 Four reviewers independently assessed the rigor of development and reporting of included guideline

204 he domains of "Stakeholder involvement" and "Rigor of Development" only scored 3/7, and "Applicabilit

205 scope and purpose, stakeholder involvement, rigor of development, and applicability domains varied c

206 n quality scores for editorial independence, rigor of development, and stakeholder engagement were al

207 poorly on AGREE II criteria, specifically in rigor of development, applicability, and editorial indep

208 Of the 21 guidelines, 17 showed considerable rigor of development.

209 domains, especially in the applicability and rigor of development.

210 Furthermore, the state-mandated rigor of diagnosis of ASD by a pediatrician or clinician

211 works to research questions can increase the rigor of epidemiologic research and increase the utility

212 ial emphasis on assessing the methodological rigor of existing research, calling attention to problem

213 n the wide variability in the methodological rigor of existing studies.

214 traction: 2 reviewers independently assessed rigor of guideline development using the Appraisal of Gu

215 An in vivo approach can complement the rigor of in vitro approaches: as studied in model organi

216 ns suggest shortcomings with authors and the rigor of journal practices.

217 as reinhardtii, demonstrated the utility and rigor of miRvial in detecting novel microRNAs and charac

218 f this new standard promises to increase the rigor of NHP transplantation studies and to ensure that

219 da-Escude and Tuomi question the statistical rigor of our analysis while ignoring the stellar activit

220 observational databases lack the scientific rigor of randomized controlled trials, they represent a

221 All methods were fully validated to the rigor of regulated bioanalysis requirements, with intrad

222 ored and validated measures has enhanced the rigor of research and clinical care.

223 There is a pressing need to increase the rigor of research in the life and biomedical sciences.

224 tain high selectivity for the importance and rigor of research while simultaneously eliminating outco

225 f of concept study targets the translational rigor of such biomarkers and aims to examine whether the

226 meningiomas are aggressive, and despite the rigor of the current histopathological classification sy

227 ress remaining uncertainties and improve the rigor of the field.

228 ar robust to variation in the methodological rigor of the included studies, based on the quality of c

229 The rigor of the method was verified in studies of guanine o

230 gardless of reporting quality or statistical rigor of the observational study.

231 The rigor of the reference standard must be assessed, such a

232 Lack of methodologic rigor of the reported studies precludes any conclusive s

233 The methodologic rigor of trials investigating simulation-based surgical

234 pecting to achieve longevity by enduring the rigors of a transplant.

235 cacious prophylactic vaccine has not met the rigors of clinical trials.

236 To withstand the rigors of contraction, muscle fibers have specialized pr

237 minating in science that could withstand the rigors of emerging legal and cultural expectations.

238 amniote model system that is amenable to the rigors of extended, high-resolution imaging and cell tra

239 stimulation in a large population under the rigors of Food and Drug Administration-approved investig

240 s remained a mystery, particularly given the rigors of intrathymic developmental checkpoints, success

241 nct physiological advantage to corals in the rigors of the reef, a crowded and fiercely competitive e

242 put operations is as important as scientific rigor" (p. 861).

243 curation is rarely performed with sufficient rigor, particularly when applying big data statistics.

244 cy and feasibility while maintaining ethical rigor, patient safety, information value, and scientific

245 cy and feasibility while maintaining ethical rigor, patient safety, information value, and scientific

246 These results indicate that post-rigor processing at 300MPa for 10min can significantly i

247 e C and E helices, and addition of Ca(2+) in rigor produced further changes characterized by increase

248 ally, analysis of the transition from ADP to rigor provides a structural rationale for force sensitiv

249 s tested (prehydrolysis, posthydrolysis, and rigor), reflects a mixture of these structural states, i

250 the center half of the I-band during 60 s of rigor, relaxation and contraction of muscle.

251 ifetimes of Tg-WT and Tg-D166V muscle during rigor, relaxation and contraction.

252 such trials sidestep mechanisms that promote rigor, relevance, efficiency, and fairness.

253 hing best practice guidelines to improve the rigor, reproducibility, and transparency of the maternal

254 ition from the force-generating ADP state to Rigor requires a 9.5 degrees rotation of the myosin leve

255 action studies on papillary muscle fibers in rigor revealed a decreased interfilament spacing ( appro

256 eats (sensitivity, 27%; 95% CI, 20%-34%) and rigors (sensitivity, 19%; 95% CI, 15%-24%) are less comm

257 35 is exposed in the relaxed state, while in rigor, Ser-35 is also exposed.

258 gically coherent literature of unprecedented rigor, size, and scope.

259 ng the apparent rate of Tn dissociation from rigor skeletal myofibrils using labeled Tn exchange.

260 stroke studies now demonstrate considerable rigor, standardization, and emphasis on minimization of

261 es in interdisciplinary research, analytical rigor, standardization, and policy development for this

262 simulation of the myosin II S1 domain in the rigor state interacting with an actin filament.

263 icroscope, myofibrils were first placed in a rigor state then stretched and shortened at different di

264 As the complex went from the rigor state to the relaxed state, the head domain of the

265 subfragment-1 molecules, interacting in the rigor state with an actin filament, has been investigate

266 ion of MgATP-independent detachment from the rigor state, as suggested by previous single-molecule me

267 In other words, starting from the post-rigor state, turning on the ATPase activity requires not

268 he structure of their strongly bound complex-rigor state-is a key for delineating the functional mech

269 silico methodology was validated by forming rigor structures that perfectly fitted into an experimen

270 these ideas with the chemical and structural rigor that electrophysiological observations naturally l

271 hen the fibers were moved from relaxation to rigor, the fluorescence lifetime increased for all label

272 ral fronts, including increased experimental rigor, the softening of dichotomies that were crucial to

273 d the physicians' impressions of the trials' rigor, their confidence in the results, and their willin

274 hese factors form impediments to statistical rigor, they can to a large extent be overcome by restric

275 Despite variability in methodological rigor, this did not moderate any of the therapy effects,

276 observational and of varying methodological rigor; thus, these findings may not be generalizable.

277 Weighted likelihood calculations bring rigor to a powerful technique.

278 onstants at different times with statistical rigor to determine if the rates at which the concentrati

279 re heterogeneous and lacked the methodologic rigor to draw any conclusions regarding the effects of d

280 adolescents, most have lacked the scientific rigor to establish clear benefits over so-called convent

281 The work presented here brings additional rigor to FRET-based studies of membrane protein interact

282 r been evaluated with sufficient statistical rigor to permit their use in regulated drug development

283 the past year utilized methods of sufficient rigor to provide a useful comparison to more conventiona

284 We add rigor to the determination of the used-new threshold by

285 The work presented here adds additional rigor to the FRET-based investigation of protein interac

286 amount to apply a strong level of scientific rigor toward a well-planned, step-wise sequence of precl

287 The cardinal symptoms (bradykinesia, rigor, tremor, and postural instability) are used for di

288 low-rigor trials than those tested in medium-rigor trials (odds ratio, 0.64; 95% confidence interval

289 igh-rigor trials than those tested in medium-rigor trials (odds ratio, 3.07; 95% CI, 2.18 to 4.32; P<

290 ess willing to prescribe drugs tested in low-rigor trials than those tested in medium-rigor trials (o

291 re willing to prescribe drugs tested in high-rigor trials than those tested in medium-rigor trials (o

292 itor (drug) screening, with an intensity and rigor unattainable through classical methods.

293 Methodological rigor was assessed using the relevant Critical Appraisal

294 Permeabilized skeletal muscle fibers in rigor were labeled with a fluorescent ATP analog, 3'-DEA

295 l fluctuations from fluorescent molecules in rigor were represented by a single Gaussian distribution

296 actin molecules in wild-type (WT) hearts in rigor were represented by perfect Gaussian curves.

297 es in retinal organoid cultures and increase rigor when utilizing them in developmental studies, dise

298 w that this is followed by pericyte death in rigor, which may irreversibly constrict capillaries and

299 We assert that measurements that combine rigor with public health relevance can accelerate progre

300 The results of these efforts and the rigor with which they are implemented will determine whe