ライフサイエンスコーパス: rigorous

1 ct meaningful evaluation measures; 9) use as rigorous a study design as is feasible; 10) think about

2 l, Meydan and Guydosh present an elegant and rigorous addition to the exciting investigation of the r

3 ns support clear public health messaging and rigorous adherence to COVID-19 prevention strategies in

4 These rigorous analyses also established that grafting reactio

5 SignalFinder-IF enables high-throughput, rigorous analyses of whole-slide, multimarker data, and

6 , we provide a comprehensive description and rigorous analysis of mammalian intrahypothalamic network

7 statistical models accordingly to provide a rigorous analysis of the HSPC lineage output.

8 an approach to address this problem through rigorous analysis of the reaction landscape guided by a

9 Rigorous analysis of the temporal relations between comp

10 c antigen receptor (CAR) T cells; however, a rigorous analysis of this approach in the context of sol

11 These advances enable rigorous analysis to establish the kinetic and mechanist

12 Our model provides a tool that connects rigorous analysis with a computational framework for und

13 ly positioned to provide a tool suitable for rigorous analysis, hypothesis generation, and connecting

14 near function of one cue), which facilitates rigorous analysis.

15 trast to the existing literature, we provide rigorous analytic characterizations of multiple modes.

16 followed by RNA sequencing, but until now, a rigorous analytic pipeline for nuclear RNA-seq has been

17 Cancer Cell, Carrot-Zhang et al., through a rigorous analytical framework, explore ancestry-specific

18 r features underlying hiCM determination and rigorous analytical pipelines for predicting cell fate c

19 pproach allows both computer simulations and rigorous analytical treatments, which lead to the follow

20 used pharmaceutical therapies, and provide a rigorous anatomical description of the bridge between th

21 when attempting to plan, conduct and publish rigorous and comprehensive evidence syntheses, we aim he

22 n R package which implements a statistically rigorous and computationally efficient approach for cond

23 , to humans-is essential to produce the most rigorous and effective medical research.

24 Nonetheless, there is a need for a rigorous and feasible line of research in the area of ai

25 ment,Development and Evaluation) is the most rigorous and fully developed.

26 Here we set a rigorous and general ME framework, the coherent ME (CME)

27 th the aim of specifying such differences, a rigorous and manageable analytical theory is deduced for

28 Additionally, defining a flexible but rigorous and reliable process of TtT 'certification' may

29 of evidence for selection in tumor, based on rigorous and robust statistics.

30 We provide a rigorous and traceable refinement of the IPCC 2006 defau

31 Using a methodologically rigorous and transparent process for evaluating health c

32 We conducted rigorous and unbiased benchmark analysis and comparisons

33 We conducted rigorous and unbiased comparisons of MDEHT with seven co

34 We used rigorous and well-established methods to develop a core

35 Trustworthy research is robust, rigorous, and transparent at all stages of design, execu

36 A modernized and rigorous approach for gene set enrichment analysis that

37 We present a rigorous approach for identifying concentration-response

38 Our rigorous approach generated a novel radiomics model that

39 DP provides a mathematically rigorous approach to prevent the risk of membership infe

40 matic reviews have been introduced as a more rigorous approach to synthesizing evidence across studie

41 de that models of DSB susceptibility offer a rigorous approach to the inference of SVs putatively sub

42 ues that are estimated using a statistically rigorous approach, that is, data assimilation, vary with

43 ohabitat relationships using a statistically rigorous approach.

44 ion of bioactivity and mechanisms of action; rigorous assessment and interpretation of prior research

45 aluation using the AUC score only, and a non-rigorous assessment of all possible combinations of radi

46 cs software and packages should facilitate a rigorous assessment of both existing and emerging statis

47 Computational tools for rigorous assessment of cell type-specific loops across m

48 gue that lesion studies are essential to the rigorous assessment of neuroscience theories.

49 In the present study, we performed the first rigorous assessment of the ability of filoviruses to pro

50 significant because it represents the first rigorous assessment of the potential for EBOV to encode

51 and purposes of fine oculomotor behavior, a rigorous assessment of the precision and accuracy of the

52 findings in mitochondrial disease, hence the rigorous assessment of these at a single cell level is i

53 However, rigorous assessment of transgene expression specificity

54 However, there are few rigorous assessments of the real-world impact of treat a

55 ixture of acetonitrile and water followed by rigorous azeotropic drying to remove the water.

56 sue biospecimens, ultimately leading to more rigorous basic and translational research.

57 oach will increase objectivity in collecting rigorous behavioral data, and it is compatible with othe

58 tion of new, incompatible tools that hinders rigorous benchmarking and complicates reproducible analy

59 Here, we undertake a rigorous biophysical analysis which leads to the concept

60 gical-nanoparticles (sub-100 nm) necessitate rigorous biophysical characterization of single EVs.

61 for the interrogation of these materials, a rigorous bridge between simulated coarse-grained structu

62 arginine forks that we have defined using a rigorous but flexible nomenclature.

63 different species and ecosystems means that rigorous case-by-case assessments are needed to fully co

64 classify these conformations, a structurally rigorous catalog of states has not been achieved.

65 Rigorous characterization found no gross abnormalities i

66 in East Africa, and the first statistically rigorous characterization of differential HLA-driven esc

67 ns at scale must overcome challenges such as rigorous clinical validation, appropriate data privacy a

68 g sites between cellular contexts requires a rigorous comparison of the corresponding ChIP-seq data.

69 After rigorous computational benchmarking, we applied our appr

70 ation techniques and automatically providing rigorous confidence intervals on the refined parameters.

71 The AHA has rigorous conflict-of-interest policies and procedures to

72 stions are offered for planning unbiased and rigorous confocal microscope experiments.

73 Through a rigorous connection with Koopman operator theory for dyn

74 cal trials, or on a case-by-case basis after rigorous consideration of the risks and benefits of this

75 XPS analysis and rigorous control experiments confirm covalent attachment

76 g improvements in medical therapy and a more rigorous control of vascular risk factors.

77 More rigorous controlled trials of interventions are needed t

78 product clinical trials prioritized based on rigorous, convergent supporting data and current public

79 elective laparoscopic colectomy and meeting rigorous criteria for ambulatory surgery were included.

80 used for coronavirus infection of cells, and rigorous criteria that should be used when identifying p

81 lassical version of the yeast PPI network in rigorous cross validation experiments.

82 By challenging our methodology with rigorous cross-validation procedures and prognostic anal

83 d-trait collection and the implementation of rigorous databases, major strides can be made at this ex

84 In the past decade rigorous debate has taken place about population-based s

85 We propose new, more rigorous definitions that account for both oncologic fac

86 al measures, we also provide an original and rigorous description of the neurophysiological basis of

87 YTRY motif should be changed to TRX, a more rigorous description of this sialic acid-recognition mot

88 Together, theory formalization and rigorous descriptive research will facilitate abductive

89 Second, we must conduct rigorous descriptive research, prioritizing direct obser

90 However, rigorous determination of SARS-CoV-2 infectivity is very

91 meet the promise of genome analyses, we urge rigorous development of biorepositories from high latitu

92 Rigorous digitally measured histologic and molecular mar

93 es the importance of patient preferences and rigorous discussion of therapeutic risks/benefits based

94 dependent reconstruction algorithms based on rigorous dynamical scattering theories, the thin-film-ba

95 assification of bladder cancer subgroups and rigorous efforts to define predictive biomarkers for can

96 Our results are analytically rigorous, empirically testable, and flexible enough to a

97 nces between animal facilities combined with rigorous environmental standardization within studies.

98 Here we provide an updated and rigorous estimate for the total mass of Rubisco on Earth

99 More comprehensive and rigorous evaluation of novel electrode materials, applic

100 this strategy is being rolled out globally, rigorous evaluation of outcomes at each stage of the ser

101 conflicts of interest, would be charged with rigorous evaluation of specific probiotic products and t

102 Rigorous evaluation of strategies to augment vaccine-ind

103 Rigorous evaluation of the instrument lineshape function

104 tivity-reaching editorial decisions based on rigorous evaluation of the research question and methodo

105 rning applications to microbiome data with a rigorous evaluation scheme.

106 tions, encouraging innovation, and requiring rigorous evaluations of their effects.

107 We systematically reviewed rigorous evaluations published between Jan 1, 2000, and

108 ebate about the health impact of probiotics, rigorous evidence assessing the use of probiotics in rou

109 Yet rigorous evidence on social and environmental outcomes o

110 ic and perinatally lethal, precluding a more rigorous examination of the effect of Alzheimer's diseas

111 molecular diagnostic assays without the more rigorous examination to which tests are normally subject

112 trochemical detection of NO in vivo requires rigorous exclusion of endogenous redox molecules such as

113 Here, we propose guidelines for rigorous experimental characterization of LLPS processes

114 This knowledge will allow for more rigorous experimental design in future studies of PDGFR

115 Rigorous experimental validation in CASP13 shows that ou

116 use key examples to illustrate how, despite rigorous experimentation and proper controls, our unders

117 LAST-based system) provide deterministic and rigorous feedback to researchers who submit sequences wi

118 a more complete sample of all tree species, rigorous field campaigns may be needed but the number of

119 itting OM to experimental data and propose a rigorous fitting procedure where K(A) and E(MAX) are der

120 In this study, we use rigorous fluid dynamic simulations to provide a physical

121 ic resonance (MR) imaging is one of the most rigorous form of imaging to assess cardiac function in v

122 This paper introduces a rigorous formalization for the additive tree, an empiric

123 imate impacts in drylands and provide a more rigorous foundation for making long-term strategic resou

124 This paper presents a systematic and rigorous framework comprised of classification, cross-va

125 summarize, our work provides a statistically rigorous framework for investigating fine-scale allele-s

126 If such work is justifiable, a serious, rigorous framework must be imposed that insures that suc

127 le-particle tracking and is a mathematically rigorous framework that can be further expanded to extra

128 ll Line Encyclopedia (CCLE), have provided a rigorous framework with which to study genetic variants,

129 We present a rigorous generic description of electrostatic and chemic

130 Moreover, using rigorous genetic manipulations, we show that SPARCL1 doe

131 y; and (iii) building on the track record of rigorous government regulation in supporting consumer ac

132 numerically efficient algorithm, combining a rigorous H-field based full-vectorial finite element met

133 d brain tissues and also demonstrated that a rigorous Hi-C bias-correction pipeline (HiCorr) can sign

134 a diverse compound screening campaign and a rigorous hit-to-lead flowchart combining biochemical and

135 This rigorous HTS approach eliminates promiscuous candidate l

136 DEEPred was optimized through rigorous hyper-parameter tests, and benchmarked using th

137 quantum correlation NMR experiments enable a rigorous identification of these silanol triad nests.

138 porate and government land-use policies, and rigorous impact assessments are needed to prevent severe

139 Most proposed road projects lack rigorous impact assessments or even basic economic justi

140 Systematic, rigorous incorporation of patient-reported outcomes in c

141 tions, comparisons among studies can be more rigorous, increasing our understanding of the ecological

142 y bottom-up MS/MS experiments using the most rigorous, industrially acceptable definition of sequence

143 n of literature data, thereby providing more rigorous insights into previous observations.

144 Toward a more rigorous inspection of food contact materials, the impor

145 Through rigorous, integrative analysis of genomics data from a r

146 nally, we show how this approach can provide rigorous interim monitoring of the trials and efficient

147 ts elicited by RNAi vectors is important for rigorous interpretation of results from RNAi-based exper

148 We therefore hypothesize that rigorous interrogation of other types of genomic changes

149 the strength of the joint implementation of rigorous inventory and atmospheric emissions monitoring

150 influenza seasons, which has resulted in the rigorous investigation of haemagglutinin, but whether ne

151 What is still needed is a rigorous investigation of these networks and of the rela

152 , and routes of transmission are still under rigorous investigation, it seems that a recollection of

153 Together, our metrics enable rigorous investigations of structure-function relationsh

154 rovide advantages to patients and hospitals, rigorous investigations on the impacts of using these as

155 Through patient involvement and rigorous, iterative psychometric evaluation, we have pro

156 hould be more systematically evaluated using rigorous laboratory-based methods and aims toward a bett

157 erform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262

158 nce of transmission trees in a statistically rigorous manner, alongside genomic data and temporal dat

159 e in comparative studies that accounts, in a rigorous manner, for biological, statistical, and techni

160 ork that naturally captures rare events in a rigorous manner, providing atomistic resolution over dif

161 c group response patterns in a statistically rigorous manner.

162 factors including, its chemical composition, rigorous manufacturing standards, and ability to target

163 Herein, we present a rigorous marker selection protocol that is applicable fo

164 We develop a rigorous mathematical framework for quantifying metastat

165 gorithms may yield practical heuristics with rigorous mathematical justification.

166 Our aim is to propose a rigorous mathematical methodology capable of unveiling t

167 It is able to provide a rigorous measure of our confidence in any putative annot

168 rmation technique that, together, permit the rigorous measurement of folding thermodynamics.

169 ciety should be prioritized for testing, and rigorous mechanisms should be in place to validate test

170 The work establishes a rigorous mechanistic model of nonfaradaic promotion in a

171 e environments, however, we currently lack a rigorous, mechanistic examination of how plasticity evol

172 tistical techniques can be used to conduct a rigorous, mechanistic program evaluation of other qualit

173 evention was analyzed using the established, rigorous median-effect model.

174 oronary CT angiography studies have included rigorous meta-analysis of its diagnostic accuracy, progn

175 spread use of this approach, there exists no rigorous method for characterizing the recruitment proce

176 ches, providing a cost-effective, rapid, and rigorous method to measure, monitor, and inform solution

177 We call for more rigorous methodology to be applied in meta-analyses of e

178 uring laundry are poorly understood and more rigorous methods for quantifying this release are needed

179 In this paper, we aim to develop rigorous methods that integrate multiple correlated trai

180 ssary controls, are supported by later, more rigorous methods.

181 evices should be evaluated against clear and rigorous metrics, primarily based on the evidence of rea

182 To address such questions, we propose a rigorous model of human computation and associated measu

183 With rigorous model training and comparison, we characterized

184 Rigorous model-based analysis can help inform state-leve

185 Patients with cirrhosis require constant and rigorous monitoring both in and outside the hospital.

186 hain-end fidelity is maintained even without rigorous monomer purification.

187 We developed a rigorous motif-based methodology to quantify variations

188 erimental results are well-supported by both rigorous multilayer optical modelling and first-principl

189 se three-dimensional measuring protocols and rigorous multivariate analysis focusing on the patterns

190 We develop a rigorous nested Jackiw-Rebbi formulation of QIs and HOFA

191 d and porous conductive inclusions suggest a rigorous new approach in geophysical exploration for min

192 focus on education and be designed with the rigorous obligations of practicing physicians in mind.

193 e met, machine learning promises a future of rigorous, outcomes-based medicine with detection, diagno

194 exome sequencing of 112 EnOC cases following rigorous pathological assessment.

195 city, which we combined with a statistically rigorous phylogenetic footprinting pipeline based on pre

196 A historical analysis both reaffirms that rigorous placebo-controlled trials remain indispensable

197 cially phase III CTs, are costly and require rigorous planning to optimize the value of the informati

198 at the nanoscale, constituting a simple yet rigorous platform to include nonclassical effects in pla

199 rce to experimental researchers, providing a rigorous platform to test hypotheses about regulation of

200 cle formation as the required input for more rigorous Population Balance models, critically including

201 Combining this structural correlation with rigorous population parameter estimation, we propose a r

202 This study provides rigorous population-level estimates of the association o

203 at reduce the complexity, cost, and waste of rigorous post-marketing research efforts.

204 However, there is an ongoing need for rigorous preclinical biomarker and target validation to

205 , or the promulgation of new standards for a rigorous preclinical testing.

206 ic growth rates is a fundamental step toward rigorous predictions of population dynamics and communit

207 uld crucially depend on thoughtful design of rigorous presymptomatic trials.

208 Differential privacy (DP) is one of the rigorous privacy concepts, which received widespread int

209 Here we propose a rigorous procedure using (15)N(2) that enables us to rel

210 A rigorous process model combined with a techno-economic a

211 ment, and input from multiple stakeholders:A rigorous process was undertaken to develop these evidenc

212 fficient process for developing transparent, rigorous product recommendations that includes myriad da

213 Using thiol-specific crosslinking we provide rigorous proof of entrapment activity in vitro.

214 f an LLCP, although they do not constitute a rigorous proof thereof.

215 artificial intelligence (AI) need to undergo rigorous, prospective evaluation to demonstrate impact o

216 artificial intelligence (AI) need to undergo rigorous, prospective evaluation to demonstrate their im

217 NESR uses a rigorous, protocol-driven methodology that is designed t

218 The resulting data underwent rigorous psychometric analysis, including factor analysi

219 nge of human traits and diseases followed by rigorous quality control.

220 ential bias was most prominent for the least-rigorous quality measures of best practices and quality

221 d in striated muscles in vivo; however, more rigorous quantitative analysis of dystrophin stability i

222 This rigorous quantitative microbial analysis framework, appr

223 ation of the amount of SOA formed requires a rigorous, quantitative understanding of chamber phenomen

224 al exposures and behavioral assessments; few rigorous quasi-experimental studies; overreliance on sel

225 This rigorous randomized controlled trial among persons with

226 sk stratification and support the need for a rigorous randomized trial.

227 sensitive to impurities and commonly require rigorous reagent purification, low temperatures, and str

228 at include other types of surgery and employ rigorous recruitment and follow-up procedures.

229 Rigorous referral pathways for molecular tests may resul

230 , revealing a highly structured, arcane, but rigorous regulatory approval process.

231 Thus, timely, rigorous, relevant, and ethical clinical research is nee

232 oal of sex and gender analysis is to promote rigorous, reproducible and responsible science.

233 More directed and rigorous research is needed to fulfill the promise of EH

234 mple of a neuropsychiatric disorder in which rigorous research on phenomenology, psychobiology, pharm

235 Beyond improved reviews, additional rigorous research on whether periodontal treatment affec

236 Accordingly, we propose additional rigorous research to test multi-component educational pr

237 As a result of a rigorous review of its governance structure, the Society

238 ied, these findings highlight the need for a rigorous safety assessment of nano-RNAi products prior t

239 We develop a practical yet rigorous scheme using the accumulated prediction error (

240 platform that would teach the principles of rigorous science to researchers at all career stages.

241 -based medicine catalyzed the development of rigorous science-based diagnostic and treatment protocol

242 cts and CBD-associated health claims lacks a rigorous scientific foundation.

243 ut there is a need to test those claims with rigorous scientific research and ground them in evidence

244 Rigorous sedimentological analysis represents a gateway

245 rial activities, a comprehensive review with rigorous selection criteria has never been performed.

246 Antibodies undergo rigorous selection to achieve this high affinity, yet so

247 ant structural changes, thus suggesting more rigorous selections of isosteric substitutes is needed.

248 ere is little empirical evidence in terms of rigorous sensory descriptive analysis or consumer prefer

249 We perform a rigorous set of experiments on these models in matched G

250 Unfortunately no technique exists for rigorous simulation of the complete imaging process, inc

251 based on detailed theoretical modelling and rigorous simulations, that it should be possible to crea

252 Via rigorous simulations, we show that Know-GRRF guided by m

253 In-silico screening of CPEs in a rigorous skin model could speed up the design of CPEs.

254 We propose a rigorous Sparse Microbial Causal Mediation Model (Sparse

255 Rigorous spatiotemporal regulation of cell division is r

256 In contrast to the current gold standard of rigorous standardization in experimental animal research

257 To achieve that promise, rigorous statistical analyses are important but not suff

258 These enrichment methods, although based on rigorous statistical foundations, are not always the bes

259 hine learning techniques, when combined with rigorous statistical mechanical analysis, are powerful t

260 In addition, rigorous statistical methods to perform differential exp

261 We build rigorous statistical models for GWAS summary statistics

262 er using three classification algorithms and rigorous statistical procedure on one of the largest dat

263 The report emphasized the primacy of rigorous statistical support from properly designed, wel

264 ion using information divergency and (iii) a rigorous statistical test for the significance of all th

265 n algorithms, unfair evaluation, and lack of rigorous statistics.

266 oint mutations, we developed a statistically rigorous strategy for combining significance levels from

267 We call for more rigorous studies of invaded community impacts across tax

268 dity and mortality are well established, few rigorous studies on this issue are available.

269 ere has been an increase in methodologically rigorous studies over time, countries that are globally

270 implementation of ACs in Zambia using a more rigorous study design.

271 AMR policy interventions are evaluated using rigorous study designs and that study results are publis

272 as a Schedule I substance, thus limiting its rigorous study for cardiovascular health effects.

273 This approach enables rigorous study of how sensory cues translate into action

274 nput; incorporation of patient perspectives; rigorous systematic review; recommendations accompanied

275 ting systematic review methodology and using rigorous systems to evaluate the certainty of the eviden

276 of treatment failure, suggesting a need for rigorous test-of-cure in clinical practice and considera

277 is to achieve an appropriate balance between rigorous testing and the need for timely approval of dru

278 Few biomarkers had rigorous testing involving multiple cohorts and only 5 o

279 generation of hypotheses and potentially the rigorous testing of mechanisms of development and diseas

280 Our results allow for rigorous testing of Rydberg interaction potentials and h

281 q data, no method is currently available for rigorous testing of the pattern differences in ribosome

282 esis in corals should allow wide-ranging and rigorous tests of gene function in both larval and adult

283 As more longer term data become available, rigorous tests of model predictions will improve.

284 conducted in autotetraploid species under a rigorous tetrasomic inheritance model.

285 b exist for RICS image acquisitioning, yet a rigorous theoretical approach to predict the accuracy an

286 re, we unravel this complexity by applying a rigorous thermodynamics approach and performing binding

287 Clearly, it would be more rigorous to infer the chemical compositions of the adduc

288 method addresses an important unmet need for rigorous tool assessment and can assist in mapping genet

289 There exist rigorous tools promoting personalized decisions with use

290 Our findings indicated that rigorous toxicological evaluations must be carried out p

291 s derived from the model lay ground for more rigorous treatment of robustness and resilience of self-

292 ce fringes with a model that includes both a rigorous treatment of the peptide's quantum wave nature

293 Stress from dealing with chronic disease and rigorous treatment regimens certainly are primary contri

294 high-quality evidence, suggesting a need for rigorous trials to address these evidence gaps in fundam

295 These experiments helped establish a rigorous understanding of structural, stereochemical, an

296 owledged to be robust to perturbations but a rigorous understanding of this has been elusive.

297 iative is to support biomarker discovery and rigorous validation in collaboration with industry leade

298 f critical components had to be subjected to rigorous validation.

299 ftware available to enable user-friendly and rigorous virtual prototyping of biological microscopy of

300 -territorial border-zones in a statistically rigorous way.